Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium falciparum.
Identifieur interne : 001152 ( PubMed/Corpus ); précédent : 001151; suivant : 001153Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium falciparum.
Auteurs : B. Sauer ; T S Skinner-Adams ; A. Bouchut ; M J Chua ; C. Pierrot ; F. Erdmann ; D. Robaa ; M. Schmidt ; J. Khalife ; K T Andrews ; W. SipplSource :
- European journal of medicinal chemistry [ 1768-3254 ] ; 2017.
English descriptors
- KwdEn :
- Antimalarials (chemical synthesis), Antimalarials (chemistry), Antimalarials (pharmacology), Antimalarials (toxicity), Caco-2 Cells, Chemistry Techniques, Synthetic, Drug Design, Furans (chemical synthesis), Furans (chemistry), Furans (pharmacology), Furans (toxicity), HEK293 Cells, Humans, Plasmodium falciparum (drug effects), Structure-Activity Relationship.
- MESH :
- chemical , chemical synthesis : Antimalarials, Furans.
- chemical , chemistry : Antimalarials, Furans.
- chemical , pharmacology : Antimalarials, Furans.
- chemical , toxicity : Antimalarials, Furans.
- drug effects : Plasmodium falciparum.
- Caco-2 Cells, Chemistry Techniques, Synthetic, Drug Design, HEK293 Cells, Humans, Structure-Activity Relationship.
Abstract
Malaria is one of the most significant tropical diseases and remains a major challenge due to the lack of a broadly effective vaccine and parasite resistance to current drugs. This means there is a need for new drug candidates with novel modes of action. Aromatic bisamidines, such as furamidine (DB75), were initially developed as anti-Trypanosoma agents however as clinical trials with furamidine highlighted potential side effects they were not pursued further in that setting. Despite apparent cytotoxicity liabilities the potency of furamidine against Plasmodium falciparum makes it a promising scaffold for the development of new anti-Plasmodium agents with improved selectivity. In this study a bisamidine compound series based on furamidine was synthesized by introducing modifications at the furan core structure and terminal amidine groups. The activity of the derived compounds was tested in vitro against drug sensitive and resistant P. falciparum lines and a human cell line (HEK293 cells) to generate anti-Plasmodium structure-activity relationships and to provide preliminary selectivity data.
DOI: 10.1016/j.ejmech.2016.12.041
PubMed: 28038325
Links to Exploration step
pubmed:28038325Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium falciparum.</title><author><name sortKey="Sauer, B" sort="Sauer, B" uniqKey="Sauer B" first="B" last="Sauer">B. Sauer</name><affiliation><nlm:affiliation>Martin-Luther-University Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120, Halle, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Skinner Adams, T S" sort="Skinner Adams, T S" uniqKey="Skinner Adams T" first="T S" last="Skinner-Adams">T S Skinner-Adams</name><affiliation><nlm:affiliation>Tropical Parasitology Lab, Eskitis Institute for Drug Discovery, Don Young Road, Griffith University, Nathan, Queensland, 4111, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Bouchut, A" sort="Bouchut, A" uniqKey="Bouchut A" first="A" last="Bouchut">A. Bouchut</name><affiliation><nlm:affiliation>U1019-CNRS UMR 8204, Univ. Lille Nord de France, Institut Pasteur de Lille, 1, Rue du professeur Calmette, 59019, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Chua, M J" sort="Chua, M J" uniqKey="Chua M" first="M J" last="Chua">M J Chua</name><affiliation><nlm:affiliation>Tropical Parasitology Lab, Eskitis Institute for Drug Discovery, Don Young Road, Griffith University, Nathan, Queensland, 4111, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Pierrot, C" sort="Pierrot, C" uniqKey="Pierrot C" first="C" last="Pierrot">C. Pierrot</name><affiliation><nlm:affiliation>U1019-CNRS UMR 8204, Univ. Lille Nord de France, Institut Pasteur de Lille, 1, Rue du professeur Calmette, 59019, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Erdmann, F" sort="Erdmann, F" uniqKey="Erdmann F" first="F" last="Erdmann">F. Erdmann</name><affiliation><nlm:affiliation>Martin-Luther-University Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120, Halle, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Robaa, D" sort="Robaa, D" uniqKey="Robaa D" first="D" last="Robaa">D. Robaa</name><affiliation><nlm:affiliation>Martin-Luther-University Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120, Halle, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Schmidt, M" sort="Schmidt, M" uniqKey="Schmidt M" first="M" last="Schmidt">M. Schmidt</name><affiliation><nlm:affiliation>Martin-Luther-University Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120, Halle, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Khalife, J" sort="Khalife, J" uniqKey="Khalife J" first="J" last="Khalife">J. Khalife</name><affiliation><nlm:affiliation>U1019-CNRS UMR 8204, Univ. Lille Nord de France, Institut Pasteur de Lille, 1, Rue du professeur Calmette, 59019, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Andrews, K T" sort="Andrews, K T" uniqKey="Andrews K" first="K T" last="Andrews">K T Andrews</name><affiliation><nlm:affiliation>Tropical Parasitology Lab, Eskitis Institute for Drug Discovery, Don Young Road, Griffith University, Nathan, Queensland, 4111, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Sippl, W" sort="Sippl, W" uniqKey="Sippl W" first="W" last="Sippl">W. Sippl</name><affiliation><nlm:affiliation>Martin-Luther-University Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120, Halle, Germany. Electronic address: wolfgang.sippl@pharmazie.uni-halle.de.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28038325</idno><idno type="pmid">28038325</idno><idno type="doi">10.1016/j.ejmech.2016.12.041</idno><idno type="wicri:Area/PubMed/Corpus">001152</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001152</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium falciparum.</title><author><name sortKey="Sauer, B" sort="Sauer, B" uniqKey="Sauer B" first="B" last="Sauer">B. Sauer</name><affiliation><nlm:affiliation>Martin-Luther-University Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120, Halle, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Skinner Adams, T S" sort="Skinner Adams, T S" uniqKey="Skinner Adams T" first="T S" last="Skinner-Adams">T S Skinner-Adams</name><affiliation><nlm:affiliation>Tropical Parasitology Lab, Eskitis Institute for Drug Discovery, Don Young Road, Griffith University, Nathan, Queensland, 4111, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Bouchut, A" sort="Bouchut, A" uniqKey="Bouchut A" first="A" last="Bouchut">A. Bouchut</name><affiliation><nlm:affiliation>U1019-CNRS UMR 8204, Univ. Lille Nord de France, Institut Pasteur de Lille, 1, Rue du professeur Calmette, 59019, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Chua, M J" sort="Chua, M J" uniqKey="Chua M" first="M J" last="Chua">M J Chua</name><affiliation><nlm:affiliation>Tropical Parasitology Lab, Eskitis Institute for Drug Discovery, Don Young Road, Griffith University, Nathan, Queensland, 4111, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Pierrot, C" sort="Pierrot, C" uniqKey="Pierrot C" first="C" last="Pierrot">C. Pierrot</name><affiliation><nlm:affiliation>U1019-CNRS UMR 8204, Univ. Lille Nord de France, Institut Pasteur de Lille, 1, Rue du professeur Calmette, 59019, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Erdmann, F" sort="Erdmann, F" uniqKey="Erdmann F" first="F" last="Erdmann">F. Erdmann</name><affiliation><nlm:affiliation>Martin-Luther-University Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120, Halle, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Robaa, D" sort="Robaa, D" uniqKey="Robaa D" first="D" last="Robaa">D. Robaa</name><affiliation><nlm:affiliation>Martin-Luther-University Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120, Halle, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Schmidt, M" sort="Schmidt, M" uniqKey="Schmidt M" first="M" last="Schmidt">M. Schmidt</name><affiliation><nlm:affiliation>Martin-Luther-University Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120, Halle, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Khalife, J" sort="Khalife, J" uniqKey="Khalife J" first="J" last="Khalife">J. Khalife</name><affiliation><nlm:affiliation>U1019-CNRS UMR 8204, Univ. Lille Nord de France, Institut Pasteur de Lille, 1, Rue du professeur Calmette, 59019, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Andrews, K T" sort="Andrews, K T" uniqKey="Andrews K" first="K T" last="Andrews">K T Andrews</name><affiliation><nlm:affiliation>Tropical Parasitology Lab, Eskitis Institute for Drug Discovery, Don Young Road, Griffith University, Nathan, Queensland, 4111, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Sippl, W" sort="Sippl, W" uniqKey="Sippl W" first="W" last="Sippl">W. Sippl</name><affiliation><nlm:affiliation>Martin-Luther-University Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120, Halle, Germany. Electronic address: wolfgang.sippl@pharmazie.uni-halle.de.</nlm:affiliation></affiliation></author></analytic><series><title level="j">European journal of medicinal chemistry</title><idno type="eISSN">1768-3254</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antimalarials (chemical synthesis)</term><term>Antimalarials (chemistry)</term><term>Antimalarials (pharmacology)</term><term>Antimalarials (toxicity)</term><term>Caco-2 Cells</term><term>Chemistry Techniques, Synthetic</term><term>Drug Design</term><term>Furans (chemical synthesis)</term><term>Furans (chemistry)</term><term>Furans (pharmacology)</term><term>Furans (toxicity)</term><term>HEK293 Cells</term><term>Humans</term><term>Plasmodium falciparum (drug effects)</term><term>Structure-Activity Relationship</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Antimalarials</term><term>Furans</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antimalarials</term><term>Furans</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antimalarials</term><term>Furans</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Antimalarials</term><term>Furans</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Plasmodium falciparum</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Caco-2 Cells</term><term>Chemistry Techniques, Synthetic</term><term>Drug Design</term><term>HEK293 Cells</term><term>Humans</term><term>Structure-Activity Relationship</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Malaria is one of the most significant tropical diseases and remains a major challenge due to the lack of a broadly effective vaccine and parasite resistance to current drugs. This means there is a need for new drug candidates with novel modes of action. Aromatic bisamidines, such as furamidine (DB75), were initially developed as anti-Trypanosoma agents however as clinical trials with furamidine highlighted potential side effects they were not pursued further in that setting. Despite apparent cytotoxicity liabilities the potency of furamidine against Plasmodium falciparum makes it a promising scaffold for the development of new anti-Plasmodium agents with improved selectivity. In this study a bisamidine compound series based on furamidine was synthesized by introducing modifications at the furan core structure and terminal amidine groups. The activity of the derived compounds was tested in vitro against drug sensitive and resistant P. falciparum lines and a human cell line (HEK293 cells) to generate anti-Plasmodium structure-activity relationships and to provide preliminary selectivity data.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28038325</PMID><DateCreated><Year>2016</Year><Month>12</Month><Day>30</Day></DateCreated><DateCompleted><Year>2017</Year><Month>02</Month><Day>21</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1768-3254</ISSN><JournalIssue CitedMedium="Internet"><Volume>127</Volume><PubDate><Year>2017</Year><Month>Feb</Month><Day>15</Day></PubDate></JournalIssue><Title>European journal of medicinal chemistry</Title><ISOAbbreviation>Eur J Med Chem</ISOAbbreviation></Journal><ArticleTitle>Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium falciparum.</ArticleTitle><Pagination><MedlinePgn>22-40</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0223-5234(16)31046-7</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ejmech.2016.12.041</ELocationID><Abstract><AbstractText>Malaria is one of the most significant tropical diseases and remains a major challenge due to the lack of a broadly effective vaccine and parasite resistance to current drugs. This means there is a need for new drug candidates with novel modes of action. Aromatic bisamidines, such as furamidine (DB75), were initially developed as anti-Trypanosoma agents however as clinical trials with furamidine highlighted potential side effects they were not pursued further in that setting. Despite apparent cytotoxicity liabilities the potency of furamidine against Plasmodium falciparum makes it a promising scaffold for the development of new anti-Plasmodium agents with improved selectivity. In this study a bisamidine compound series based on furamidine was synthesized by introducing modifications at the furan core structure and terminal amidine groups. The activity of the derived compounds was tested in vitro against drug sensitive and resistant P. falciparum lines and a human cell line (HEK293 cells) to generate anti-Plasmodium structure-activity relationships and to provide preliminary selectivity data.</AbstractText><CopyrightInformation>Copyright © 2016 Elsevier Masson SAS. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sauer</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Martin-Luther-University Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120, Halle, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Skinner-Adams</LastName><ForeName>T S</ForeName><Initials>TS</Initials><AffiliationInfo><Affiliation>Tropical Parasitology Lab, Eskitis Institute for Drug Discovery, Don Young Road, Griffith University, Nathan, Queensland, 4111, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bouchut</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>U1019-CNRS UMR 8204, Univ. Lille Nord de France, Institut Pasteur de Lille, 1, Rue du professeur Calmette, 59019, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chua</LastName><ForeName>M J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Tropical Parasitology Lab, Eskitis Institute for Drug Discovery, Don Young Road, Griffith University, Nathan, Queensland, 4111, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pierrot</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>U1019-CNRS UMR 8204, Univ. Lille Nord de France, Institut Pasteur de Lille, 1, Rue du professeur Calmette, 59019, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Erdmann</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Martin-Luther-University Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120, Halle, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Robaa</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Martin-Luther-University Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120, Halle, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmidt</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Martin-Luther-University Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120, Halle, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khalife</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>U1019-CNRS UMR 8204, Univ. Lille Nord de France, Institut Pasteur de Lille, 1, Rue du professeur Calmette, 59019, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Andrews</LastName><ForeName>K T</ForeName><Initials>KT</Initials><AffiliationInfo><Affiliation>Tropical Parasitology Lab, Eskitis Institute for Drug Discovery, Don Young Road, Griffith University, Nathan, Queensland, 4111, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sippl</LastName><ForeName>W</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Martin-Luther-University Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120, Halle, Germany. Electronic address: wolfgang.sippl@pharmazie.uni-halle.de.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>12</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>Eur J Med Chem</MedlineTA><NlmUniqueID>0420510</NlmUniqueID><ISSNLinking>0223-5234</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000962">Antimalarials</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005663">Furans</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C469777">bisamidine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000962" MajorTopicYN="N">Antimalarials</DescriptorName><QualifierName UI="Q000138" MajorTopicYN="Y">chemical synthesis</QualifierName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018938" MajorTopicYN="N">Caco-2 Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D060326" MajorTopicYN="N">Chemistry Techniques, Synthetic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015195" MajorTopicYN="N">Drug Design</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005663" MajorTopicYN="N">Furans</DescriptorName><QualifierName UI="Q000138" MajorTopicYN="Y">chemical synthesis</QualifierName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D057809" MajorTopicYN="N">HEK293 Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010963" MajorTopicYN="N">Plasmodium falciparum</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013329" MajorTopicYN="N">Structure-Activity Relationship</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Bisamidine</Keyword><Keyword MajorTopicYN="N">Cytotoxicity</Keyword><Keyword MajorTopicYN="N">Furamidine</Keyword><Keyword MajorTopicYN="N">Plasmodium falciparum</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>10</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>12</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>12</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>12</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>2</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>12</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28038325</ArticleId><ArticleId IdType="pii">S0223-5234(16)31046-7</ArticleId><ArticleId IdType="doi">10.1016/j.ejmech.2016.12.041</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001152 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 001152 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:28038325
|texte= Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium falciparum.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:28038325" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |