Synergistic deleterious effect of hypoxemia and hypovolemia on microcirculation in intestinal villi*.
Identifieur interne : 003893 ( PubMed/Checkpoint ); précédent : 003892; suivant : 003894Synergistic deleterious effect of hypoxemia and hypovolemia on microcirculation in intestinal villi*.
Auteurs : Anatole Harrois [France] ; Nathalie Baudry ; Olivier Huet ; Hiromi Kato ; Manuel Lohez ; Marianne Ziol ; Jacques Duranteau ; Eric VicautSource :
- Critical care medicine [ 1530-0293 ] ; 2013.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Muqueuse intestinale.
- métabolisme : Granulocytes neutrophiles.
- physiologie : Adhérence cellulaire, Microcirculation.
- Animaux, Attribution aléatoire, Humains, Hypovolémie, Hypoxie, Hémodynamique, Muqueuse intestinale, Mâle, Souris, Souris de lignée BALB C.
English descriptors
- KwdEn :
- MESH :
- blood supply : Intestinal Mucosa.
- complications : Hypovolemia, Hypoxia.
- metabolism : Neutrophils.
- pathology : Intestinal Mucosa.
- physiology : Cell Adhesion, Microcirculation.
- Animals, Hemodynamics, Humans, Male, Mice, Mice, Inbred BALB C, Random Allocation.
Abstract
To investigate the effect of hypoxemia, hemorrhagic shock, and the association of both of these on intestinal microcirculation (microcirculatory perfusion and leukocytes-endothelium interactions in postcapillary venules), as it can be encountered in hemorrhagic shock following trauma.
DOI: 10.1097/CCM.0b013e318292388d
PubMed: 23963129
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:23963129Le document en format XML
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<term>Cell Adhesion (physiology)</term>
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<term>Humans</term>
<term>Hypovolemia (complications)</term>
<term>Hypoxia (complications)</term>
<term>Intestinal Mucosa (blood supply)</term>
<term>Intestinal Mucosa (pathology)</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Microcirculation (physiology)</term>
<term>Neutrophils (metabolism)</term>
<term>Random Allocation</term>
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<term>Animaux</term>
<term>Attribution aléatoire</term>
<term>Granulocytes neutrophiles (métabolisme)</term>
<term>Humains</term>
<term>Hypovolémie ()</term>
<term>Hypoxie ()</term>
<term>Hémodynamique</term>
<term>Microcirculation (physiologie)</term>
<term>Muqueuse intestinale ()</term>
<term>Muqueuse intestinale (anatomopathologie)</term>
<term>Mâle</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
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<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Muqueuse intestinale</term>
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<keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Intestinal Mucosa</term>
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<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Hypovolemia</term>
<term>Hypoxia</term>
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<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Neutrophils</term>
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<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Granulocytes neutrophiles</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Intestinal Mucosa</term>
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<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Adhérence cellulaire</term>
<term>Microcirculation</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cell Adhesion</term>
<term>Microcirculation</term>
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<term>Hemodynamics</term>
<term>Humans</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Random Allocation</term>
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<term>Hypovolémie</term>
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<term>Hémodynamique</term>
<term>Muqueuse intestinale</term>
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<front><div type="abstract" xml:lang="en">To investigate the effect of hypoxemia, hemorrhagic shock, and the association of both of these on intestinal microcirculation (microcirculatory perfusion and leukocytes-endothelium interactions in postcapillary venules), as it can be encountered in hemorrhagic shock following trauma.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23963129</PMID>
<DateCreated><Year>2013</Year>
<Month>10</Month>
<Day>28</Day>
</DateCreated>
<DateCompleted><Year>2013</Year>
<Month>12</Month>
<Day>24</Day>
</DateCompleted>
<DateRevised><Year>2016</Year>
<Month>11</Month>
<Day>25</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1530-0293</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>41</Volume>
<Issue>11</Issue>
<PubDate><Year>2013</Year>
<Month>Nov</Month>
</PubDate>
</JournalIssue>
<Title>Critical care medicine</Title>
<ISOAbbreviation>Crit. Care Med.</ISOAbbreviation>
</Journal>
<ArticleTitle>Synergistic deleterious effect of hypoxemia and hypovolemia on microcirculation in intestinal villi*.</ArticleTitle>
<Pagination><MedlinePgn>e376-84</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1097/CCM.0b013e318292388d</ELocationID>
<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To investigate the effect of hypoxemia, hemorrhagic shock, and the association of both of these on intestinal microcirculation (microcirculatory perfusion and leukocytes-endothelium interactions in postcapillary venules), as it can be encountered in hemorrhagic shock following trauma.</AbstractText>
<AbstractText Label="DESIGN" NlmCategory="METHODS">Prospective controlled experimental study.</AbstractText>
<AbstractText Label="SETTING" NlmCategory="METHODS">University research laboratory.</AbstractText>
<AbstractText Label="SUBJECTS" NlmCategory="METHODS">Forty-eight anesthetized and mechanically ventilated Balb/c mice.</AbstractText>
<AbstractText Label="INTERVENTION" NlmCategory="METHODS">Mice were randomly assigned to hypoxemia group in which we decreased inspired oxygen fraction during 60 minutes to reach a PaO2 of 40 mm Hg, hemorrhagic shock group in which animals were exsanguinated to a mean arterial pressure level of 40 mm Hg during 30 minutes, hypoxemia-hemorrhagic shock group in which PaO2 was decreased to 40 mm Hg during 60 minutes with exsanguination from the 30th to the 60th minute to a mean arterial pressure level of 40 mm Hg; or control group.</AbstractText>
<AbstractText Label="MEASUREMENTS AND MAIN RESULTS" NlmCategory="RESULTS">Hypoxemia decreased RBCs velocity in intestinal villi but did not alter the fraction of perfused villi. Hypoxemia also triggered leukocytes adhesion to the venular endothelium. Hemorrhagic shock not only decreased RBCs velocity in villi but also slightly altered the fraction of perfused villi (94% ± 2% in hemorrhagic shock group vs 100% ± 0% in control group, p < 0.005). Furthermore, hemorrhagic shock triggered leukocytes adhesion to the venular endothelium to the same extent as hypoxemia. When hypoxemia was associated to hemorrhagic shock, it decreased villous RBCs velocity in an additive manner and the fraction of perfused villi dropped in a synergistic manner (69% ± 3% in hypoxemia-hemorrhagic shock group vs 94 ± 2 in hemorrhagic shock group, p < 0.005). The association of hypoxemia and hemorrhagic shock did not further amplify leukocytes adhesion to intestinal venules compared with either hypoxemia or hemorrhagic shock alone.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">During hemorrhagic shock, the occurrence of hypoxemia considerably alters villous intestinal perfusion as it decreases the fraction of perfused villi in a synergistic manner, thereby increasing the risk of villous ischemia. The association of hypoxemia and hemorrhagic shock did not amplify leukocytes adhesion to the endothelium further than either hemorrhagic shock or hypoxemia alone did. As hypoxemia frequently occurs simultaneously with hemorrhagic shock in traumatic conditions, it can worsen gut ischemia leading to the exacerbation of multiple organ failure syndrome.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Harrois</LastName>
<ForeName>Anatole</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>1Laboratoire de Microcirculation, Energétique, Inflammation, Insuffisance Circulatoire Aigue, Université Paris VII-XI-XIII, Paris, France. 2Service d'Anesthésie-Réanimation Chirurgicale, Hôpital de Bicêtre, Université Paris-Sud, Hôpitaux universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, France. 3BakerIDI Heart and Diabetes Institute, Monash University, Melbourne, Australia. 4Service d'Anatomie pathologique, Groupe hospitalier Paris-Seine-Saint Denis, Hopital Jean Verdier, AP-HP, Bondy, France. 5France et Universite Paris 13, Sorbonne Paris Cite, UFR SMBH, Bobigny, France.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Baudry</LastName>
<ForeName>Nathalie</ForeName>
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<Author ValidYN="Y"><LastName>Huet</LastName>
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<Initials>O</Initials>
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<ForeName>Hiromi</ForeName>
<Initials>H</Initials>
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<ForeName>Manuel</ForeName>
<Initials>M</Initials>
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<Author ValidYN="Y"><LastName>Ziol</LastName>
<ForeName>Marianne</ForeName>
<Initials>M</Initials>
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<Author ValidYN="Y"><LastName>Duranteau</LastName>
<ForeName>Jacques</ForeName>
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<ForeName>Eric</ForeName>
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<Language>eng</Language>
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<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
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<MeshHeading><DescriptorName UI="D020896" MajorTopicYN="N">Hypovolemia</DescriptorName>
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<MeshHeading><DescriptorName UI="D000860" MajorTopicYN="N">Hypoxia</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
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<MeshHeading><DescriptorName UI="D007413" MajorTopicYN="N">Intestinal Mucosa</DescriptorName>
<QualifierName UI="Q000098" MajorTopicYN="Y">blood supply</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
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<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
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<MeshHeading><DescriptorName UI="D008807" MajorTopicYN="N">Mice, Inbred BALB C</DescriptorName>
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<MeshHeading><DescriptorName UI="D008833" MajorTopicYN="N">Microcirculation</DescriptorName>
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<MeshHeading><DescriptorName UI="D009504" MajorTopicYN="N">Neutrophils</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
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<MeshHeading><DescriptorName UI="D011897" MajorTopicYN="N">Random Allocation</DescriptorName>
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<country name="France"><region name="Île-de-France"><name sortKey="Harrois, Anatole" sort="Harrois, Anatole" uniqKey="Harrois A" first="Anatole" last="Harrois">Anatole Harrois</name>
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