Synergistic deleterious effect of hypoxemia and hypovolemia on microcirculation in intestinal villi*.
Identifieur interne : 003A98 ( PubMed/Corpus ); précédent : 003A97; suivant : 003A99Synergistic deleterious effect of hypoxemia and hypovolemia on microcirculation in intestinal villi*.
Auteurs : Anatole Harrois ; Nathalie Baudry ; Olivier Huet ; Hiromi Kato ; Manuel Lohez ; Marianne Ziol ; Jacques Duranteau ; Eric VicautSource :
- Critical care medicine [ 1530-0293 ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- blood supply : Intestinal Mucosa.
- complications : Hypovolemia, Hypoxia.
- metabolism : Neutrophils.
- pathology : Intestinal Mucosa.
- physiology : Cell Adhesion, Microcirculation.
- Animals, Hemodynamics, Humans, Male, Mice, Mice, Inbred BALB C, Random Allocation.
Abstract
To investigate the effect of hypoxemia, hemorrhagic shock, and the association of both of these on intestinal microcirculation (microcirculatory perfusion and leukocytes-endothelium interactions in postcapillary venules), as it can be encountered in hemorrhagic shock following trauma.
DOI: 10.1097/CCM.0b013e318292388d
PubMed: 23963129
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pubmed:23963129Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Synergistic deleterious effect of hypoxemia and hypovolemia on microcirculation in intestinal villi*.</title><author><name sortKey="Harrois, Anatole" sort="Harrois, Anatole" uniqKey="Harrois A" first="Anatole" last="Harrois">Anatole Harrois</name><affiliation><nlm:affiliation>1Laboratoire de Microcirculation, Energétique, Inflammation, Insuffisance Circulatoire Aigue, Université Paris VII-XI-XIII, Paris, France. 2Service d'Anesthésie-Réanimation Chirurgicale, Hôpital de Bicêtre, Université Paris-Sud, Hôpitaux universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, France. 3BakerIDI Heart and Diabetes Institute, Monash University, Melbourne, Australia. 4Service d'Anatomie pathologique, Groupe hospitalier Paris-Seine-Saint Denis, Hopital Jean Verdier, AP-HP, Bondy, France. 5France et Universite Paris 13, Sorbonne Paris Cite, UFR SMBH, Bobigny, France.</nlm:affiliation></affiliation></author><author><name sortKey="Baudry, Nathalie" sort="Baudry, Nathalie" uniqKey="Baudry N" first="Nathalie" last="Baudry">Nathalie Baudry</name></author><author><name sortKey="Huet, Olivier" sort="Huet, Olivier" uniqKey="Huet O" first="Olivier" last="Huet">Olivier Huet</name></author><author><name sortKey="Kato, Hiromi" sort="Kato, Hiromi" uniqKey="Kato H" first="Hiromi" last="Kato">Hiromi Kato</name></author><author><name sortKey="Lohez, Manuel" sort="Lohez, Manuel" uniqKey="Lohez M" first="Manuel" last="Lohez">Manuel Lohez</name></author><author><name sortKey="Ziol, Marianne" sort="Ziol, Marianne" uniqKey="Ziol M" first="Marianne" last="Ziol">Marianne Ziol</name></author><author><name sortKey="Duranteau, Jacques" sort="Duranteau, Jacques" uniqKey="Duranteau J" first="Jacques" last="Duranteau">Jacques Duranteau</name></author><author><name sortKey="Vicaut, Eric" sort="Vicaut, Eric" uniqKey="Vicaut E" first="Eric" last="Vicaut">Eric Vicaut</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23963129</idno><idno type="pmid">23963129</idno><idno type="doi">10.1097/CCM.0b013e318292388d</idno><idno type="wicri:Area/PubMed/Corpus">003A98</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003A98</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Synergistic deleterious effect of hypoxemia and hypovolemia on microcirculation in intestinal villi*.</title><author><name sortKey="Harrois, Anatole" sort="Harrois, Anatole" uniqKey="Harrois A" first="Anatole" last="Harrois">Anatole Harrois</name><affiliation><nlm:affiliation>1Laboratoire de Microcirculation, Energétique, Inflammation, Insuffisance Circulatoire Aigue, Université Paris VII-XI-XIII, Paris, France. 2Service d'Anesthésie-Réanimation Chirurgicale, Hôpital de Bicêtre, Université Paris-Sud, Hôpitaux universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, France. 3BakerIDI Heart and Diabetes Institute, Monash University, Melbourne, Australia. 4Service d'Anatomie pathologique, Groupe hospitalier Paris-Seine-Saint Denis, Hopital Jean Verdier, AP-HP, Bondy, France. 5France et Universite Paris 13, Sorbonne Paris Cite, UFR SMBH, Bobigny, France.</nlm:affiliation></affiliation></author><author><name sortKey="Baudry, Nathalie" sort="Baudry, Nathalie" uniqKey="Baudry N" first="Nathalie" last="Baudry">Nathalie Baudry</name></author><author><name sortKey="Huet, Olivier" sort="Huet, Olivier" uniqKey="Huet O" first="Olivier" last="Huet">Olivier Huet</name></author><author><name sortKey="Kato, Hiromi" sort="Kato, Hiromi" uniqKey="Kato H" first="Hiromi" last="Kato">Hiromi Kato</name></author><author><name sortKey="Lohez, Manuel" sort="Lohez, Manuel" uniqKey="Lohez M" first="Manuel" last="Lohez">Manuel Lohez</name></author><author><name sortKey="Ziol, Marianne" sort="Ziol, Marianne" uniqKey="Ziol M" first="Marianne" last="Ziol">Marianne Ziol</name></author><author><name sortKey="Duranteau, Jacques" sort="Duranteau, Jacques" uniqKey="Duranteau J" first="Jacques" last="Duranteau">Jacques Duranteau</name></author><author><name sortKey="Vicaut, Eric" sort="Vicaut, Eric" uniqKey="Vicaut E" first="Eric" last="Vicaut">Eric Vicaut</name></author></analytic><series><title level="j">Critical care medicine</title><idno type="eISSN">1530-0293</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Adhesion (physiology)</term><term>Hemodynamics</term><term>Humans</term><term>Hypovolemia (complications)</term><term>Hypoxia (complications)</term><term>Intestinal Mucosa (blood supply)</term><term>Intestinal Mucosa (pathology)</term><term>Male</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Microcirculation (physiology)</term><term>Neutrophils (metabolism)</term><term>Random Allocation</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Intestinal Mucosa</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Hypovolemia</term><term>Hypoxia</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Neutrophils</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Intestinal Mucosa</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cell Adhesion</term><term>Microcirculation</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Hemodynamics</term><term>Humans</term><term>Male</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Random Allocation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To investigate the effect of hypoxemia, hemorrhagic shock, and the association of both of these on intestinal microcirculation (microcirculatory perfusion and leukocytes-endothelium interactions in postcapillary venules), as it can be encountered in hemorrhagic shock following trauma.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23963129</PMID><DateCreated><Year>2013</Year><Month>10</Month><Day>28</Day></DateCreated><DateCompleted><Year>2013</Year><Month>12</Month><Day>24</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>25</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1530-0293</ISSN><JournalIssue CitedMedium="Internet"><Volume>41</Volume><Issue>11</Issue><PubDate><Year>2013</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Critical care medicine</Title><ISOAbbreviation>Crit. Care Med.</ISOAbbreviation></Journal><ArticleTitle>Synergistic deleterious effect of hypoxemia and hypovolemia on microcirculation in intestinal villi*.</ArticleTitle><Pagination><MedlinePgn>e376-84</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/CCM.0b013e318292388d</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To investigate the effect of hypoxemia, hemorrhagic shock, and the association of both of these on intestinal microcirculation (microcirculatory perfusion and leukocytes-endothelium interactions in postcapillary venules), as it can be encountered in hemorrhagic shock following trauma.</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">Prospective controlled experimental study.</AbstractText><AbstractText Label="SETTING" NlmCategory="METHODS">University research laboratory.</AbstractText><AbstractText Label="SUBJECTS" NlmCategory="METHODS">Forty-eight anesthetized and mechanically ventilated Balb/c mice.</AbstractText><AbstractText Label="INTERVENTION" NlmCategory="METHODS">Mice were randomly assigned to hypoxemia group in which we decreased inspired oxygen fraction during 60 minutes to reach a PaO2 of 40 mm Hg, hemorrhagic shock group in which animals were exsanguinated to a mean arterial pressure level of 40 mm Hg during 30 minutes, hypoxemia-hemorrhagic shock group in which PaO2 was decreased to 40 mm Hg during 60 minutes with exsanguination from the 30th to the 60th minute to a mean arterial pressure level of 40 mm Hg; or control group.</AbstractText><AbstractText Label="MEASUREMENTS AND MAIN RESULTS" NlmCategory="RESULTS">Hypoxemia decreased RBCs velocity in intestinal villi but did not alter the fraction of perfused villi. Hypoxemia also triggered leukocytes adhesion to the venular endothelium. Hemorrhagic shock not only decreased RBCs velocity in villi but also slightly altered the fraction of perfused villi (94% ± 2% in hemorrhagic shock group vs 100% ± 0% in control group, p < 0.005). Furthermore, hemorrhagic shock triggered leukocytes adhesion to the venular endothelium to the same extent as hypoxemia. When hypoxemia was associated to hemorrhagic shock, it decreased villous RBCs velocity in an additive manner and the fraction of perfused villi dropped in a synergistic manner (69% ± 3% in hypoxemia-hemorrhagic shock group vs 94 ± 2 in hemorrhagic shock group, p < 0.005). The association of hypoxemia and hemorrhagic shock did not further amplify leukocytes adhesion to intestinal venules compared with either hypoxemia or hemorrhagic shock alone.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">During hemorrhagic shock, the occurrence of hypoxemia considerably alters villous intestinal perfusion as it decreases the fraction of perfused villi in a synergistic manner, thereby increasing the risk of villous ischemia. The association of hypoxemia and hemorrhagic shock did not amplify leukocytes adhesion to the endothelium further than either hemorrhagic shock or hypoxemia alone did. As hypoxemia frequently occurs simultaneously with hemorrhagic shock in traumatic conditions, it can worsen gut ischemia leading to the exacerbation of multiple organ failure syndrome.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Harrois</LastName><ForeName>Anatole</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>1Laboratoire de Microcirculation, Energétique, Inflammation, Insuffisance Circulatoire Aigue, Université Paris VII-XI-XIII, Paris, France. 2Service d'Anesthésie-Réanimation Chirurgicale, Hôpital de Bicêtre, Université Paris-Sud, Hôpitaux universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, France. 3BakerIDI Heart and Diabetes Institute, Monash University, Melbourne, Australia. 4Service d'Anatomie pathologique, Groupe hospitalier Paris-Seine-Saint Denis, Hopital Jean Verdier, AP-HP, Bondy, France. 5France et Universite Paris 13, Sorbonne Paris Cite, UFR SMBH, Bobigny, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baudry</LastName><ForeName>Nathalie</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Huet</LastName><ForeName>Olivier</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Kato</LastName><ForeName>Hiromi</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Lohez</LastName><ForeName>Manuel</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Ziol</LastName><ForeName>Marianne</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Duranteau</LastName><ForeName>Jacques</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Vicaut</LastName><ForeName>Eric</ForeName><Initials>E</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Crit Care Med</MedlineTA><NlmUniqueID>0355501</NlmUniqueID><ISSNLinking>0090-3493</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Crit Care Med. 2014 Mar;42(3):e242</RefSource><PMID Version="1">24534978</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>Crit Care Med. 2014 Mar;42(3):e242-3</RefSource><PMID Version="1">24534979</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>Crit Care Med. 2013 Nov;41(11):2664-5</RefSource><PMID Version="1">24162687</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002448" MajorTopicYN="N">Cell Adhesion</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006439" MajorTopicYN="N">Hemodynamics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020896" MajorTopicYN="N">Hypovolemia</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000860" MajorTopicYN="N">Hypoxia</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007413" MajorTopicYN="N">Intestinal Mucosa</DescriptorName><QualifierName UI="Q000098" MajorTopicYN="Y">blood supply</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008807" MajorTopicYN="N">Mice, Inbred BALB C</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008833" MajorTopicYN="N">Microcirculation</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009504" MajorTopicYN="N">Neutrophils</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011897" MajorTopicYN="N">Random Allocation</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>8</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>8</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>12</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23963129</ArticleId><ArticleId IdType="doi">10.1097/CCM.0b013e318292388d</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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