Benchmarking and validation of a Geant4-SHADOW Monte Carlo simulation for dose calculations in microbeam radiation therapy.
Identifieur interne : 003794 ( PubMed/Checkpoint ); précédent : 003793; suivant : 003795Benchmarking and validation of a Geant4-SHADOW Monte Carlo simulation for dose calculations in microbeam radiation therapy.
Auteurs : Iwan Cornelius [Australie] ; Susanna Guatelli [Australie] ; Pauline Fournier [Australie] ; Jeffrey C. Crosbie [Australie] ; Manuel Sanchez Del Rio [France] ; Elke Br Uer-Krisch [France] ; Anatoly Rosenfeld [Australie] ; Michael Lerch [Australie]Source :
- Journal of synchrotron radiation [ 1600-5775 ] ; 2014.
Abstract
Microbeam radiation therapy (MRT) is a synchrotron-based radiotherapy modality that uses high-intensity beams of spatially fractionated radiation to treat tumours. The rapid evolution of MRT towards clinical trials demands accurate treatment planning systems (TPS), as well as independent tools for the verification of TPS calculated dose distributions in order to ensure patient safety and treatment efficacy. Monte Carlo computer simulation represents the most accurate method of dose calculation in patient geometries and is best suited for the purpose of TPS verification. A Monte Carlo model of the ID17 biomedical beamline at the European Synchrotron Radiation Facility has been developed, including recent modifications, using the Geant4 Monte Carlo toolkit interfaced with the SHADOW X-ray optics and ray-tracing libraries. The code was benchmarked by simulating dose profiles in water-equivalent phantoms subject to irradiation by broad-beam (without spatial fractionation) and microbeam (with spatial fractionation) fields, and comparing against those calculated with a previous model of the beamline developed using the PENELOPE code. Validation against additional experimental dose profiles in water-equivalent phantoms subject to broad-beam irradiation was also performed. Good agreement between codes was observed, with the exception of out-of-field doses and toward the field edge for larger field sizes. Microbeam results showed good agreement between both codes and experimental results within uncertainties. Results of the experimental validation showed agreement for different beamline configurations. The asymmetry in the out-of-field dose profiles due to polarization effects was also investigated, yielding important information for the treatment planning process in MRT. This work represents an important step in the development of a Monte Carlo-based independent verification tool for treatment planning in MRT.
DOI: 10.1107/S1600577514004640
PubMed: 24763641
Affiliations:
- Australie, France
- Auvergne-Rhône-Alpes, Rhône-Alpes, Victoria (État)
- Grenoble, Melbourne
- Université de Melbourne
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Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Medical Radiation Physics, University of Wollongong, New South Wales 2522</wicri:regionArea><wicri:noRegion>New South Wales 2522</wicri:noRegion></affiliation></author><author><name sortKey="Guatelli, Susanna" sort="Guatelli, Susanna" uniqKey="Guatelli S" first="Susanna" last="Guatelli">Susanna Guatelli</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Medical Radiation Physics, University of Wollongong, New South Wales 2522, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Medical Radiation Physics, University of Wollongong, New South Wales 2522</wicri:regionArea><wicri:noRegion>New South Wales 2522</wicri:noRegion></affiliation></author><author><name sortKey="Fournier, Pauline" sort="Fournier, Pauline" uniqKey="Fournier P" first="Pauline" last="Fournier">Pauline Fournier</name><affiliation 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Crosbie</name><affiliation wicri:level="4"><nlm:affiliation>Department of Obstetrics and Gynaecology, The University of Melbourne, Parkville, Victoria 3152, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Obstetrics and Gynaecology, The University of Melbourne, Parkville, Victoria 3152</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Sanchez Del Rio, Manuel" sort="Sanchez Del Rio, Manuel" uniqKey="Sanchez Del Rio M" first="Manuel" last="Sanchez Del Rio">Manuel Sanchez Del Rio</name><affiliation wicri:level="3"><nlm:affiliation>European Synchrotron Radiation Facility, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>European Synchrotron Radiation Facility, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Br Uer Krisch, Elke" sort="Br Uer Krisch, Elke" uniqKey="Br Uer Krisch E" first="Elke" last="Br Uer-Krisch">Elke Br Uer-Krisch</name><affiliation wicri:level="3"><nlm:affiliation>European Synchrotron Radiation Facility, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>European Synchrotron Radiation Facility, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Rosenfeld, Anatoly" sort="Rosenfeld, Anatoly" uniqKey="Rosenfeld A" first="Anatoly" last="Rosenfeld">Anatoly Rosenfeld</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Medical Radiation Physics, University of Wollongong, New South Wales 2522, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Medical Radiation Physics, University of Wollongong, New South Wales 2522</wicri:regionArea><wicri:noRegion>New South Wales 2522</wicri:noRegion></affiliation></author><author><name sortKey="Lerch, Michael" sort="Lerch, Michael" uniqKey="Lerch M" first="Michael" last="Lerch">Michael Lerch</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Medical Radiation Physics, University of Wollongong, New South Wales 2522, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Medical Radiation Physics, University of Wollongong, New South Wales 2522</wicri:regionArea><wicri:noRegion>New South Wales 2522</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of synchrotron radiation</title><idno type="eISSN">1600-5775</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Microbeam radiation therapy (MRT) is a synchrotron-based radiotherapy modality that uses high-intensity beams of spatially fractionated radiation to treat tumours. The rapid evolution of MRT towards clinical trials demands accurate treatment planning systems (TPS), as well as independent tools for the verification of TPS calculated dose distributions in order to ensure patient safety and treatment efficacy. Monte Carlo computer simulation represents the most accurate method of dose calculation in patient geometries and is best suited for the purpose of TPS verification. A Monte Carlo model of the ID17 biomedical beamline at the European Synchrotron Radiation Facility has been developed, including recent modifications, using the Geant4 Monte Carlo toolkit interfaced with the SHADOW X-ray optics and ray-tracing libraries. The code was benchmarked by simulating dose profiles in water-equivalent phantoms subject to irradiation by broad-beam (without spatial fractionation) and microbeam (with spatial fractionation) fields, and comparing against those calculated with a previous model of the beamline developed using the PENELOPE code. Validation against additional experimental dose profiles in water-equivalent phantoms subject to broad-beam irradiation was also performed. Good agreement between codes was observed, with the exception of out-of-field doses and toward the field edge for larger field sizes. Microbeam results showed good agreement between both codes and experimental results within uncertainties. Results of the experimental validation showed agreement for different beamline configurations. The asymmetry in the out-of-field dose profiles due to polarization effects was also investigated, yielding important information for the treatment planning process in MRT. This work represents an important step in the development of a Monte Carlo-based independent verification tool for treatment planning in MRT.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">24763641</PMID><DateCreated><Year>2014</Year><Month>04</Month><Day>25</Day></DateCreated><DateCompleted><Year>2015</Year><Month>03</Month><Day>30</Day></DateCompleted><DateRevised><Year>2014</Year><Month>04</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1600-5775</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>Pt 3</Issue><PubDate><Year>2014</Year><Month>May</Month></PubDate></JournalIssue><Title>Journal of synchrotron radiation</Title><ISOAbbreviation>J Synchrotron Radiat</ISOAbbreviation></Journal><ArticleTitle>Benchmarking and validation of a Geant4-SHADOW Monte Carlo simulation for dose calculations in microbeam radiation therapy.</ArticleTitle><Pagination><MedlinePgn>518-28</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1107/S1600577514004640</ELocationID><Abstract><AbstractText>Microbeam radiation therapy (MRT) is a synchrotron-based radiotherapy modality that uses high-intensity beams of spatially fractionated radiation to treat tumours. The rapid evolution of MRT towards clinical trials demands accurate treatment planning systems (TPS), as well as independent tools for the verification of TPS calculated dose distributions in order to ensure patient safety and treatment efficacy. Monte Carlo computer simulation represents the most accurate method of dose calculation in patient geometries and is best suited for the purpose of TPS verification. A Monte Carlo model of the ID17 biomedical beamline at the European Synchrotron Radiation Facility has been developed, including recent modifications, using the Geant4 Monte Carlo toolkit interfaced with the SHADOW X-ray optics and ray-tracing libraries. The code was benchmarked by simulating dose profiles in water-equivalent phantoms subject to irradiation by broad-beam (without spatial fractionation) and microbeam (with spatial fractionation) fields, and comparing against those calculated with a previous model of the beamline developed using the PENELOPE code. Validation against additional experimental dose profiles in water-equivalent phantoms subject to broad-beam irradiation was also performed. Good agreement between codes was observed, with the exception of out-of-field doses and toward the field edge for larger field sizes. Microbeam results showed good agreement between both codes and experimental results within uncertainties. Results of the experimental validation showed agreement for different beamline configurations. The asymmetry in the out-of-field dose profiles due to polarization effects was also investigated, yielding important information for the treatment planning process in MRT. This work represents an important step in the development of a Monte Carlo-based independent verification tool for treatment planning in MRT.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cornelius</LastName><ForeName>Iwan</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Centre for Medical Radiation Physics, University of Wollongong, New South Wales 2522, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guatelli</LastName><ForeName>Susanna</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Centre for Medical Radiation Physics, University of Wollongong, New South Wales 2522, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fournier</LastName><ForeName>Pauline</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Centre for Medical Radiation Physics, University of Wollongong, New South Wales 2522, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Crosbie</LastName><ForeName>Jeffrey C</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Department of Obstetrics and Gynaecology, The University of Melbourne, Parkville, Victoria 3152, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sanchez Del Rio</LastName><ForeName>Manuel</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>European Synchrotron Radiation Facility, Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bräuer-Krisch</LastName><ForeName>Elke</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>European Synchrotron Radiation Facility, Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rosenfeld</LastName><ForeName>Anatoly</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Centre for Medical Radiation Physics, University of Wollongong, New South Wales 2522, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lerch</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Centre for Medical Radiation Physics, University of Wollongong, New South Wales 2522, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>04</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Synchrotron Radiat</MedlineTA><NlmUniqueID>9888878</NlmUniqueID><ISSNLinking>0909-0495</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Monte Carlo</Keyword><Keyword MajorTopicYN="N">dosimetry</Keyword><Keyword MajorTopicYN="N">microbeam radiation therapy</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>10</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>02</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>4</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>4</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>4</Month><Day>26</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24763641</ArticleId><ArticleId IdType="pii">S1600577514004640</ArticleId><ArticleId IdType="doi">10.1107/S1600577514004640</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li><li>Victoria (État)</li></region><settlement><li>Grenoble</li><li>Melbourne</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><country name="Australie"><noRegion><name sortKey="Cornelius, Iwan" sort="Cornelius, Iwan" uniqKey="Cornelius I" first="Iwan" last="Cornelius">Iwan Cornelius</name></noRegion><name sortKey="Crosbie, Jeffrey C" sort="Crosbie, Jeffrey C" uniqKey="Crosbie J" first="Jeffrey C" last="Crosbie">Jeffrey C. Crosbie</name><name sortKey="Fournier, Pauline" sort="Fournier, Pauline" uniqKey="Fournier P" first="Pauline" last="Fournier">Pauline Fournier</name><name sortKey="Guatelli, Susanna" sort="Guatelli, Susanna" uniqKey="Guatelli S" first="Susanna" last="Guatelli">Susanna Guatelli</name><name sortKey="Lerch, Michael" sort="Lerch, Michael" uniqKey="Lerch M" first="Michael" last="Lerch">Michael Lerch</name><name sortKey="Rosenfeld, Anatoly" sort="Rosenfeld, Anatoly" uniqKey="Rosenfeld A" first="Anatoly" last="Rosenfeld">Anatoly Rosenfeld</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Sanchez Del Rio, Manuel" sort="Sanchez Del Rio, Manuel" uniqKey="Sanchez Del Rio M" first="Manuel" last="Sanchez Del Rio">Manuel Sanchez Del Rio</name></region><name sortKey="Br Uer Krisch, Elke" sort="Br Uer Krisch, Elke" uniqKey="Br Uer Krisch E" first="Elke" last="Br Uer-Krisch">Elke Br Uer-Krisch</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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