AustralieFrV1, PubMed, Checkpoint, bibRecord, 003498

Host range of the potential biopesticide Pea Albumin 1b (PA1b) is limited to insects.

Identifieur interne : 003498 ( PubMed/Checkpoint ); précédent : 003497; suivant : 003499

Host range of the potential biopesticide Pea Albumin 1b (PA1b) is limited to insects.

Auteurs : Isabelle Rahioui [France] ; Vanessa Eyraud [France] ; Lamis Karaki [France] ; Florenz Sasse [Allemagne] ; Maïté Carre-Pierrat [France] ; An Qin [République populaire de Chine] ; Ming H. Zheng [Australie] ; Stefan Toepfer [République populaire de Chine] ; Catherine Sivignon [France] ; Corinne Royer [France] ; Pedro Da Silva [France] ; Frédéric Gressent [France]

Source :

Toxicon : official journal of the International Society on Toxinology [ 1879-3150 ] ; 2014.

RBID : pubmed:25064271

Descripteurs français

English descriptors

KwdEn :
- Amino Acid Sequence, Animals, Beetles (drug effects), Cell Differentiation (drug effects), Cell Line, Tumor, Drosophila melanogaster (drug effects), Fabaceae (chemistry), Humans, Insect Proteins (chemistry), Insecticide Resistance, Insects (drug effects), MCF-7 Cells, Mice, Molecular Sequence Data, Osteoclasts (drug effects), Pesticides (chemistry), Pesticides (toxicity), Plant Proteins (chemistry), Plant Proteins (toxicity), Seeds (chemistry), Toxicity Tests, Vacuolar Proton-Translocating ATPases (chemistry).
MESH :
- chemical , chemistry : Insect Proteins, Pesticides, Plant Proteins, Vacuolar Proton-Translocating ATPases.
- chemistry : Fabaceae, Seeds.
- drug effects : Beetles, Cell Differentiation, Drosophila melanogaster, Insects, Osteoclasts.
- chemical , toxicity : Pesticides, Plant Proteins.
- Amino Acid Sequence, Animals, Cell Line, Tumor, Humans, Insecticide Resistance, MCF-7 Cells, Mice, Molecular Sequence Data, Toxicity Tests.

Abstract

The Pea Albumin 1 subunit b (PA1b) peptide is an entomotoxin extracted from legume seeds with lethal activity towards several insect pests. Its toxic activity occurs after the perception of PA1b by a plasmalemmic proton pump (V-ATPase) in the insects. Assays revealed that PA1b showed no activity towards mammalian cells displaying high V-ATPase activity. Similarly, PA1b displayed no binding activity and no biological activity towards other non-insect organisms. We demonstrate here that binding to labelled PA1b was found in all the insect families tested, regardless of the sensitivity or insensitivity of the individual species. The coleopteran Bruchidae, which are mainly legume seed pests, were found to be fully resistant. A number of insect species were seen to be insensitive to the toxin although they exhibited binding activity for the labelled PA1b. The fruit fly, Drosophila melanogaster (Diptera), was generally insensitive when maintained on an agar diet, but the fly appeared to be sensitive to PA1b in bioassays using a different diet. In conclusion, the PA1b toxin provides legumes with a major source of resistance to insects, and insects feeding on legume seeds need to overcome this plant resistance by disrupting the PA1b - V-ATPase interaction.

DOI: 10.1016/j.toxicon.2014.07.004
PubMed: 25064271

Affiliations:

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<country xml:lang="fr">France</country>
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<series><title level="j">Toxicon : official journal of the International Society on Toxinology</title>
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<term>Animals</term>
<term>Beetles (drug effects)</term>
<term>Cell Differentiation (drug effects)</term>
<term>Cell Line, Tumor</term>
<term>Drosophila melanogaster (drug effects)</term>
<term>Fabaceae (chemistry)</term>
<term>Humans</term>
<term>Insect Proteins (chemistry)</term>
<term>Insecticide Resistance</term>
<term>Insects (drug effects)</term>
<term>MCF-7 Cells</term>
<term>Mice</term>
<term>Molecular Sequence Data</term>
<term>Osteoclasts (drug effects)</term>
<term>Pesticides (chemistry)</term>
<term>Pesticides (toxicity)</term>
<term>Plant Proteins (chemistry)</term>
<term>Plant Proteins (toxicity)</term>
<term>Seeds (chemistry)</term>
<term>Toxicity Tests</term>
<term>Vacuolar Proton-Translocating ATPases (chemistry)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Cellules MCF-7</term>
<term>Coléoptères ()</term>
<term>Différenciation cellulaire ()</term>
<term>Données de séquences moléculaires</term>
<term>Drosophila melanogaster ()</term>
<term>Fabaceae ()</term>
<term>Graines ()</term>
<term>Humains</term>
<term>Insectes ()</term>
<term>Lignée cellulaire tumorale</term>
<term>Ostéoclastes ()</term>
<term>Pesticides ()</term>
<term>Pesticides (toxicité)</term>
<term>Protéines d'insecte ()</term>
<term>Protéines végétales ()</term>
<term>Protéines végétales (toxicité)</term>
<term>Résistance aux insecticides</term>
<term>Souris</term>
<term>Séquence d'acides aminés</term>
<term>Tests de toxicité</term>
<term>Vacuolar Proton-Translocating ATPases ()</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Insect Proteins</term>
<term>Pesticides</term>
<term>Plant Proteins</term>
<term>Vacuolar Proton-Translocating ATPases</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Fabaceae</term>
<term>Seeds</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Beetles</term>
<term>Cell Differentiation</term>
<term>Drosophila melanogaster</term>
<term>Insects</term>
<term>Osteoclasts</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Pesticides</term>
<term>Plant Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Pesticides</term>
<term>Protéines végétales</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Cell Line, Tumor</term>
<term>Humans</term>
<term>Insecticide Resistance</term>
<term>MCF-7 Cells</term>
<term>Mice</term>
<term>Molecular Sequence Data</term>
<term>Toxicity Tests</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules MCF-7</term>
<term>Coléoptères</term>
<term>Différenciation cellulaire</term>
<term>Données de séquences moléculaires</term>
<term>Drosophila melanogaster</term>
<term>Fabaceae</term>
<term>Graines</term>
<term>Humains</term>
<term>Insectes</term>
<term>Lignée cellulaire tumorale</term>
<term>Ostéoclastes</term>
<term>Pesticides</term>
<term>Protéines d'insecte</term>
<term>Protéines végétales</term>
<term>Résistance aux insecticides</term>
<term>Souris</term>
<term>Séquence d'acides aminés</term>
<term>Tests de toxicité</term>
<term>Vacuolar Proton-Translocating ATPases</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en">The Pea Albumin 1 subunit b (PA1b) peptide is an entomotoxin extracted from legume seeds with lethal activity towards several insect pests. Its toxic activity occurs after the perception of PA1b by a plasmalemmic proton pump (V-ATPase) in the insects. Assays revealed that PA1b showed no activity towards mammalian cells displaying high V-ATPase activity. Similarly, PA1b displayed no binding activity and no biological activity towards other non-insect organisms. We demonstrate here that binding to labelled PA1b was found in all the insect families tested, regardless of the sensitivity or insensitivity of the individual species. The coleopteran Bruchidae, which are mainly legume seed pests, were found to be fully resistant. A number of insect species were seen to be insensitive to the toxin although they exhibited binding activity for the labelled PA1b. The fruit fly, Drosophila melanogaster (Diptera), was generally insensitive when maintained on an agar diet, but the fly appeared to be sensitive to PA1b in bioassays using a different diet. In conclusion, the PA1b toxin provides legumes with a major source of resistance to insects, and insects feeding on legume seeds need to overcome this plant resistance by disrupting the PA1b - V-ATPase interaction.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25064271</PMID>
<DateCreated><Year>2014</Year>
<Month>08</Month>
<Day>18</Day>
</DateCreated>
<DateCompleted><Year>2015</Year>
<Month>04</Month>
<Day>23</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>11</Month>
<Day>16</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-3150</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>89</Volume>
<PubDate><Year>2014</Year>
<Month>Oct</Month>
</PubDate>
</JournalIssue>
<Title>Toxicon : official journal of the International Society on Toxinology</Title>
<ISOAbbreviation>Toxicon</ISOAbbreviation>
</Journal>
<ArticleTitle>Host range of the potential biopesticide Pea Albumin 1b (PA1b) is limited to insects.</ArticleTitle>
<Pagination><MedlinePgn>67-76</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.toxicon.2014.07.004</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">S0041-0101(14)00194-9</ELocationID>
<Abstract><AbstractText>The Pea Albumin 1 subunit b (PA1b) peptide is an entomotoxin extracted from legume seeds with lethal activity towards several insect pests. Its toxic activity occurs after the perception of PA1b by a plasmalemmic proton pump (V-ATPase) in the insects. Assays revealed that PA1b showed no activity towards mammalian cells displaying high V-ATPase activity. Similarly, PA1b displayed no binding activity and no biological activity towards other non-insect organisms. We demonstrate here that binding to labelled PA1b was found in all the insect families tested, regardless of the sensitivity or insensitivity of the individual species. The coleopteran Bruchidae, which are mainly legume seed pests, were found to be fully resistant. A number of insect species were seen to be insensitive to the toxin although they exhibited binding activity for the labelled PA1b. The fruit fly, Drosophila melanogaster (Diptera), was generally insensitive when maintained on an agar diet, but the fly appeared to be sensitive to PA1b in bioassays using a different diet. In conclusion, the PA1b toxin provides legumes with a major source of resistance to insects, and insects feeding on legume seeds need to overcome this plant resistance by disrupting the PA1b - V-ATPase interaction.</AbstractText>
<CopyrightInformation>Copyright © 2014 Elsevier Ltd. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rahioui</LastName>
<ForeName>Isabelle</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>INRA, INSA-Lyon, Université de Lyon, UMR203 BF2I, Biologie Fonctionnelle Insectes et Interactions, Bat. Louis-Pasteur, 20 av. Albert Einstein, F-69621 Villeurbanne, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Eyraud</LastName>
<ForeName>Vanessa</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>INRA, INSA-Lyon, Université de Lyon, UMR203 BF2I, Biologie Fonctionnelle Insectes et Interactions, Bat. Louis-Pasteur, 20 av. Albert Einstein, F-69621 Villeurbanne, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Karaki</LastName>
<ForeName>Lamis</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>INRA, INSA-Lyon, Université de Lyon, UMR203 BF2I, Biologie Fonctionnelle Insectes et Interactions, Bat. Louis-Pasteur, 20 av. Albert Einstein, F-69621 Villeurbanne, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sasse</LastName>
<ForeName>Florenz</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Department of Chemical Biology, Helmholtz Centre for Infection Research, Inhoffenstr. 7, 38124 Braunschweig, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Carre-Pierrat</LastName>
<ForeName>Maïté</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Biology of Caenorhabditis elegans Facility, CNRS UMS 3421, Campus de la Doua, 16 rue Dubois, 69622 Villeurbanne, France; Université Claude Bernard Lyon 1, 43 bd du 11 Novembre, F-69622 Villeurbanne, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Qin</LastName>
<ForeName>An</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Centre for Orthopaedic Research, School of Surgery, University of Western Australia, Perth, Australia; Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zheng</LastName>
<ForeName>Ming H</ForeName>
<Initials>MH</Initials>
<AffiliationInfo><Affiliation>Centre for Orthopaedic Research, School of Surgery, University of Western Australia, Perth, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Toepfer</LastName>
<ForeName>Stefan</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Chinese Ministry of Agriculture - CABI Joint Laboratory for Biosafety, Yuanmingyuan Western Road 2, CN - 100193 Beijing, PR China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sivignon</LastName>
<ForeName>Catherine</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>INRA, INSA-Lyon, Université de Lyon, UMR203 BF2I, Biologie Fonctionnelle Insectes et Interactions, Bat. Louis-Pasteur, 20 av. Albert Einstein, F-69621 Villeurbanne, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Royer</LastName>
<ForeName>Corinne</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>INRA, INSA-Lyon, Université de Lyon, UMR203 BF2I, Biologie Fonctionnelle Insectes et Interactions, Bat. Louis-Pasteur, 20 av. Albert Einstein, F-69621 Villeurbanne, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Da Silva</LastName>
<ForeName>Pedro</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>INRA, INSA-Lyon, Université de Lyon, UMR203 BF2I, Biologie Fonctionnelle Insectes et Interactions, Bat. Louis-Pasteur, 20 av. Albert Einstein, F-69621 Villeurbanne, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gressent</LastName>
<ForeName>Frédéric</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>INRA, INSA-Lyon, Université de Lyon, UMR203 BF2I, Biologie Fonctionnelle Insectes et Interactions, Bat. Louis-Pasteur, 20 av. Albert Einstein, F-69621 Villeurbanne, France. Electronic address: Frederic.Gressent@supagro.inra.fr.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2014</Year>
<Month>07</Month>
<Day>23</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Toxicon</MedlineTA>
<NlmUniqueID>1307333</NlmUniqueID>
<ISSNLinking>0041-0101</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D019476">Insect Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D010575">Pesticides</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D010940">Plant Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.6.1.-</RegistryNumber>
<NameOfSubstance UI="D025262">Vacuolar Proton-Translocating ATPases</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001517" MajorTopicYN="N">Beetles</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002454" MajorTopicYN="N">Cell Differentiation</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045744" MajorTopicYN="N">Cell Line, Tumor</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004331" MajorTopicYN="N">Drosophila melanogaster</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007887" MajorTopicYN="N">Fabaceae</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019476" MajorTopicYN="N">Insect Proteins</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007305" MajorTopicYN="N">Insecticide Resistance</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007313" MajorTopicYN="N">Insects</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D061986" MajorTopicYN="N">MCF-7 Cells</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010010" MajorTopicYN="N">Osteoclasts</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010575" MajorTopicYN="N">Pesticides</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010940" MajorTopicYN="N">Plant Proteins</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012639" MajorTopicYN="N">Seeds</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018675" MajorTopicYN="N">Toxicity Tests</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D025262" MajorTopicYN="N">Vacuolar Proton-Translocating ATPases</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Biopesticide</Keyword>
<Keyword MajorTopicYN="N">Insect</Keyword>
<Keyword MajorTopicYN="N">Non-target effects</Keyword>
<Keyword MajorTopicYN="N">PA1b</Keyword>
<Keyword MajorTopicYN="N">Pea Albumin 1 subunit b</Keyword>
<Keyword MajorTopicYN="N">V-ATPase</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year>
<Month>03</Month>
<Day>19</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2014</Year>
<Month>06</Month>
<Day>04</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2014</Year>
<Month>07</Month>
<Day>15</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2014</Year>
<Month>7</Month>
<Day>28</Day>
<Hour>6</Hour>
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<PubMedPubDate PubStatus="pubmed"><Year>2014</Year>
<Month>7</Month>
<Day>30</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2015</Year>
<Month>4</Month>
<Day>24</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">25064271</ArticleId>
<ArticleId IdType="pii">S0041-0101(14)00194-9</ArticleId>
<ArticleId IdType="doi">10.1016/j.toxicon.2014.07.004</ArticleId>
</ArticleIdList>
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</pubmed>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>France</li>
<li>République populaire de Chine</li>
</country>
<region><li>Auvergne-Rhône-Alpes</li>
<li>Rhône-Alpes</li>
</region>
<settlement><li>Villeurbanne</li>
</settlement>
</list>
<tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Rahioui, Isabelle" sort="Rahioui, Isabelle" uniqKey="Rahioui I" first="Isabelle" last="Rahioui">Isabelle Rahioui</name>
</region>
<name sortKey="Carre Pierrat, Maite" sort="Carre Pierrat, Maite" uniqKey="Carre Pierrat M" first="Maïté" last="Carre-Pierrat">Maïté Carre-Pierrat</name>
<name sortKey="Da Silva, Pedro" sort="Da Silva, Pedro" uniqKey="Da Silva P" first="Pedro" last="Da Silva">Pedro Da Silva</name>
<name sortKey="Eyraud, Vanessa" sort="Eyraud, Vanessa" uniqKey="Eyraud V" first="Vanessa" last="Eyraud">Vanessa Eyraud</name>
<name sortKey="Gressent, Frederic" sort="Gressent, Frederic" uniqKey="Gressent F" first="Frédéric" last="Gressent">Frédéric Gressent</name>
<name sortKey="Karaki, Lamis" sort="Karaki, Lamis" uniqKey="Karaki L" first="Lamis" last="Karaki">Lamis Karaki</name>
<name sortKey="Royer, Corinne" sort="Royer, Corinne" uniqKey="Royer C" first="Corinne" last="Royer">Corinne Royer</name>
<name sortKey="Sivignon, Catherine" sort="Sivignon, Catherine" uniqKey="Sivignon C" first="Catherine" last="Sivignon">Catherine Sivignon</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="Sasse, Florenz" sort="Sasse, Florenz" uniqKey="Sasse F" first="Florenz" last="Sasse">Florenz Sasse</name>
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<country name="République populaire de Chine"><noRegion><name sortKey="Qin, An" sort="Qin, An" uniqKey="Qin A" first="An" last="Qin">An Qin</name>
</noRegion>
<name sortKey="Toepfer, Stefan" sort="Toepfer, Stefan" uniqKey="Toepfer S" first="Stefan" last="Toepfer">Stefan Toepfer</name>
</country>
<country name="Australie"><noRegion><name sortKey="Zheng, Ming H" sort="Zheng, Ming H" uniqKey="Zheng M" first="Ming H" last="Zheng">Ming H. Zheng</name>
</noRegion>
</country>
</tree>
</affiliations>
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Host range of the potential biopesticide Pea Albumin 1b (PA1b) is limited to insects.

Host range of the potential biopesticide Pea Albumin 1b (PA1b) is limited to insects.

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