AustralieFrV1, PubMed, Checkpoint, bibRecord, 003121

The potential of composite cognitive scores for tracking progression in Huntington's disease.

Identifieur interne : 003121 ( PubMed/Checkpoint ); précédent : 003120; suivant : 003122

The potential of composite cognitive scores for tracking progression in Huntington's disease.

Auteurs : Rebecca Jones [Royaume-Uni] ; Julie C. Stout [Australie] ; Izelle Labuschagne [Australie] ; Miranda Say [Royaume-Uni] ; Damian Justo [France] ; Allison Coleman [Canada] ; Eve M. Dumas [Pays-Bas] ; Ellen Hart [Pays-Bas] ; Gail Owen [Royaume-Uni] ; Alexandra Durr [France] ; Blair R. Leavitt [Canada] ; Raymund Roos [Pays-Bas] ; Alison O'Regan [Australie] ; Doug Langbehn [États-Unis] ; Sarah J. Tabrizi [Royaume-Uni] ; Chris Frost [Royaume-Uni]

Source :

Journal of Huntington's disease [ 1879-6397 ] ; 2014.

RBID : pubmed:25062862

Descripteurs français

KwdFr :
- Adulte, Adulte d'âge moyen, Femelle, Humains, Maladie de Huntington (), Maladie de Huntington (physiopathologie), Modèles statistiques, Mâle, Tests neuropsychologiques, Troubles de la cognition (diagnostic), Troubles de la cognition (physiopathologie), Troubles de la cognition (étiologie), Vieillissement (physiologie), Études longitudinales, Évolution de la maladie.
MESH :
- diagnostic : Troubles de la cognition.
- physiologie : Vieillissement.
- physiopathologie : Maladie de Huntington, Troubles de la cognition.
- étiologie : Troubles de la cognition.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Maladie de Huntington, Modèles statistiques, Mâle, Tests neuropsychologiques, Études longitudinales, Évolution de la maladie.

English descriptors

KwdEn :
- Adult, Aging (physiology), Cognition Disorders (diagnosis), Cognition Disorders (etiology), Cognition Disorders (physiopathology), Disease Progression, Female, Humans, Huntington Disease (complications), Huntington Disease (physiopathology), Longitudinal Studies, Male, Middle Aged, Models, Statistical, Neuropsychological Tests.
MESH :
- complications : Huntington Disease.
- diagnosis : Cognition Disorders.
- etiology : Cognition Disorders.
- physiology : Aging.
- physiopathology : Cognition Disorders, Huntington Disease.
- Adult, Disease Progression, Female, Humans, Longitudinal Studies, Male, Middle Aged, Models, Statistical, Neuropsychological Tests.

Abstract

Composite scores derived from joint statistical modelling of individual risk factors are widely used to identify individuals who are at increased risk of developing disease or of faster disease progression.

DOI: 10.3233/JHD-140101
PubMed: 25062862

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 003A21
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Links to Exploration step

pubmed:25062862

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aging (physiology)</term>
<term>Cognition Disorders (diagnosis)</term>
<term>Cognition Disorders (etiology)</term>
<term>Cognition Disorders (physiopathology)</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Humans</term>
<term>Huntington Disease (complications)</term>
<term>Huntington Disease (physiopathology)</term>
<term>Longitudinal Studies</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Models, Statistical</term>
<term>Neuropsychological Tests</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Femelle</term>
<term>Humains</term>
<term>Maladie de Huntington ()</term>
<term>Maladie de Huntington (physiopathologie)</term>
<term>Modèles statistiques</term>
<term>Mâle</term>
<term>Tests neuropsychologiques</term>
<term>Troubles de la cognition (diagnostic)</term>
<term>Troubles de la cognition (physiopathologie)</term>
<term>Troubles de la cognition (étiologie)</term>
<term>Vieillissement (physiologie)</term>
<term>Études longitudinales</term>
<term>Évolution de la maladie</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Huntington Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cognition Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Troubles de la cognition</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Vieillissement</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Aging</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Maladie de Huntington</term>
<term>Troubles de la cognition</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cognition Disorders</term>
<term>Huntington Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Troubles de la cognition</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Humans</term>
<term>Longitudinal Studies</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Models, Statistical</term>
<term>Neuropsychological Tests</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Femelle</term>
<term>Humains</term>
<term>Maladie de Huntington</term>
<term>Modèles statistiques</term>
<term>Mâle</term>
<term>Tests neuropsychologiques</term>
<term>Études longitudinales</term>
<term>Évolution de la maladie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Composite scores derived from joint statistical modelling of individual risk factors are widely used to identify individuals who are at increased risk of developing disease or of faster disease progression.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25062862</PMID>
<DateCreated><Year>2014</Year>
<Month>07</Month>
<Day>26</Day>
</DateCreated>
<DateCompleted><Year>2014</Year>
<Month>09</Month>
<Day>23</Day>
</DateCompleted>
<DateRevised><Year>2016</Year>
<Month>04</Month>
<Day>11</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">1879-6397</ISSN>
<JournalIssue CitedMedium="Print"><Volume>3</Volume>
<Issue>2</Issue>
<PubDate><Year>2014</Year>
</PubDate>
</JournalIssue>
<Title>Journal of Huntington's disease</Title>
<ISOAbbreviation>J Huntingtons Dis</ISOAbbreviation>
</Journal>
<ArticleTitle>The potential of composite cognitive scores for tracking progression in Huntington's disease.</ArticleTitle>
<Pagination><MedlinePgn>197-207</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.3233/JHD-140101</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Composite scores derived from joint statistical modelling of individual risk factors are widely used to identify individuals who are at increased risk of developing disease or of faster disease progression.</AbstractText>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">We investigated the ability of composite measures developed using statistical models to differentiate progressive cognitive deterioration in Huntington's disease (HD) from natural decline in healthy controls.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Using longitudinal data from TRACK-HD, the optimal combinations of quantitative cognitive measures to differentiate premanifest and early stage HD individuals respectively from controls was determined using logistic regression. Composite scores were calculated from the parameters of each statistical model. Linear regression models were used to calculate effect sizes (ES) quantifying the difference in longitudinal change over 24 months between premanifest and early stage HD groups respectively and controls. ES for the composites were compared with ES for individual cognitive outcomes and other measures used in HD research. The 0.632 bootstrap was used to eliminate biases which result from developing and testing models in the same sample.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">In early HD, the composite score from the HD change prediction model produced an ES for difference in rate of 24-month change relative to controls of 1.14 (95% CI: 0.90 to 1.39), larger than the ES for any individual cognitive outcome and UHDRS Total Motor Score and Total Functional Capacity. In addition, this composite gave a statistically significant difference in rate of change in premanifest HD compared to controls over 24-months (ES: 0.24; 95% CI: 0.04 to 0.44), even though none of the individual cognitive outcomes produced statistically significant ES over this period.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Composite scores developed using appropriate statistical modelling techniques have the potential to materially reduce required sample sizes for randomised controlled trials.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Jones</LastName>
<ForeName>Rebecca</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Stout</LastName>
<ForeName>Julie C</ForeName>
<Initials>JC</Initials>
<AffiliationInfo><Affiliation>School of Psychology and Psychiatry, Monash University, Melbourne, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Labuschagne</LastName>
<ForeName>Izelle</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>School of Psychology and Psychiatry, Monash University, Melbourne, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Say</LastName>
<ForeName>Miranda</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>UCL Institute of Neurology, University College London, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Justo</LastName>
<ForeName>Damian</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Inserm, UMR_S975, CRICM and UPMC Univ Paris 06, UMR_S975 and CNRS UMR 7225, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Coleman</LastName>
<ForeName>Allison</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Medical Genetics, University of British Columbia, Vancouver, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dumas</LastName>
<ForeName>Eve M</ForeName>
<Initials>EM</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hart</LastName>
<ForeName>Ellen</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Owen</LastName>
<ForeName>Gail</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>UCL Institute of Neurology, University College London, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Durr</LastName>
<ForeName>Alexandra</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Inserm, UMR_S975, CRICM and UPMC Univ Paris 06, UMR_S975 and CNRS UMR 7225, Paris, France AP-HP, Hôpital de la Salpêtriére, Département de Génétique et Cytogénétique, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Leavitt</LastName>
<ForeName>Blair R</ForeName>
<Initials>BR</Initials>
<AffiliationInfo><Affiliation>Department of Medical Genetics, University of British Columbia, Vancouver, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Roos</LastName>
<ForeName>Raymund</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>O'Regan</LastName>
<ForeName>Alison</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>School of Psychology and Psychiatry, Monash University, Melbourne, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Langbehn</LastName>
<ForeName>Doug</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Departments of Psychiatry and Biostatistics, University of Iowa, IA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tabrizi</LastName>
<ForeName>Sarah J</ForeName>
<Initials>SJ</Initials>
<AffiliationInfo><Affiliation>UCL Institute of Neurology, University College London, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Frost</LastName>
<ForeName>Chris</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D064888">Observational Study</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>Netherlands</Country>
<MedlineTA>J Huntingtons Dis</MedlineTA>
<NlmUniqueID>101589965</NlmUniqueID>
<ISSNLinking>1879-6397</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000375" MajorTopicYN="N">Aging</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003072" MajorTopicYN="N">Cognition Disorders</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018450" MajorTopicYN="N">Disease Progression</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006816" MajorTopicYN="N">Huntington Disease</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008137" MajorTopicYN="N">Longitudinal Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015233" MajorTopicYN="N">Models, Statistical</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009483" MajorTopicYN="N">Neuropsychological Tests</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">0.632 bootstrap</Keyword>
<Keyword MajorTopicYN="N">Huntington disease</Keyword>
<Keyword MajorTopicYN="N">cognition</Keyword>
<Keyword MajorTopicYN="N">composite score</Keyword>
<Keyword MajorTopicYN="N">effect size</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year>
<Month>7</Month>
<Day>27</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2014</Year>
<Month>7</Month>
<Day>27</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2014</Year>
<Month>9</Month>
<Day>24</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">25062862</ArticleId>
<ArticleId IdType="pii">M212N55P1N410784</ArticleId>
<ArticleId IdType="doi">10.3233/JHD-140101</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Australie</li>
<li>Canada</li>
<li>France</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Grand Londres</li>
<li>Hollande-Méridionale</li>
<li>Iowa</li>
<li>Victoria (État)</li>
<li>Île-de-France</li>
</region>
<settlement><li>Iowa City</li>
<li>Leyde</li>
<li>Londres</li>
<li>Melbourne</li>
<li>Paris</li>
</settlement>
<orgName><li>University College de Londres</li>
<li>Université de l'Iowa</li>
</orgName>
</list>
<tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Jones, Rebecca" sort="Jones, Rebecca" uniqKey="Jones R" first="Rebecca" last="Jones">Rebecca Jones</name>
</region>
<name sortKey="Frost, Chris" sort="Frost, Chris" uniqKey="Frost C" first="Chris" last="Frost">Chris Frost</name>
<name sortKey="Owen, Gail" sort="Owen, Gail" uniqKey="Owen G" first="Gail" last="Owen">Gail Owen</name>
<name sortKey="Say, Miranda" sort="Say, Miranda" uniqKey="Say M" first="Miranda" last="Say">Miranda Say</name>
<name sortKey="Tabrizi, Sarah J" sort="Tabrizi, Sarah J" uniqKey="Tabrizi S" first="Sarah J" last="Tabrizi">Sarah J. Tabrizi</name>
</country>
<country name="Australie"><region name="Victoria (État)"><name sortKey="Stout, Julie C" sort="Stout, Julie C" uniqKey="Stout J" first="Julie C" last="Stout">Julie C. Stout</name>
</region>
<name sortKey="Labuschagne, Izelle" sort="Labuschagne, Izelle" uniqKey="Labuschagne I" first="Izelle" last="Labuschagne">Izelle Labuschagne</name>
<name sortKey="O Regan, Alison" sort="O Regan, Alison" uniqKey="O Regan A" first="Alison" last="O'Regan">Alison O'Regan</name>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Justo, Damian" sort="Justo, Damian" uniqKey="Justo D" first="Damian" last="Justo">Damian Justo</name>
</region>
<name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Durr">Alexandra Durr</name>
</country>
<country name="Canada"><noRegion><name sortKey="Coleman, Allison" sort="Coleman, Allison" uniqKey="Coleman A" first="Allison" last="Coleman">Allison Coleman</name>
</noRegion>
<name sortKey="Leavitt, Blair R" sort="Leavitt, Blair R" uniqKey="Leavitt B" first="Blair R" last="Leavitt">Blair R. Leavitt</name>
</country>
<country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Dumas, Eve M" sort="Dumas, Eve M" uniqKey="Dumas E" first="Eve M" last="Dumas">Eve M. Dumas</name>
</region>
<name sortKey="Hart, Ellen" sort="Hart, Ellen" uniqKey="Hart E" first="Ellen" last="Hart">Ellen Hart</name>
<name sortKey="Roos, Raymund" sort="Roos, Raymund" uniqKey="Roos R" first="Raymund" last="Roos">Raymund Roos</name>
</country>
<country name="États-Unis"><region name="Iowa"><name sortKey="Langbehn, Doug" sort="Langbehn, Doug" uniqKey="Langbehn D" first="Doug" last="Langbehn">Doug Langbehn</name>
</region>
</country>
</tree>
</affiliations>
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The potential of composite cognitive scores for tracking progression in Huntington's disease.

The potential of composite cognitive scores for tracking progression in Huntington's disease.

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