The predictive role of interim positron emission tomography for Hodgkin lymphoma treatment outcome is confirmed using the interpretation criteria of the Deauville five-point scale.
Identifieur interne : 003120 ( PubMed/Checkpoint ); précédent : 003119; suivant : 003121The predictive role of interim positron emission tomography for Hodgkin lymphoma treatment outcome is confirmed using the interpretation criteria of the Deauville five-point scale.
Auteurs : Andrea Gallamini [Italie] ; Sally F. Barrington [Royaume-Uni] ; Alberto Biggi [Italie] ; Stephane Chauvie [Italie] ; Lale Kostakoglu [États-Unis] ; Michele Gregianin [Italie] ; Michel Meignan [France] ; George N. Mikhaeel [Royaume-Uni] ; Annika Loft [Danemark] ; Jan M. Zaucha [Pologne] ; John F. Seymour [Australie] ; Michael S. Hofman [Australie] ; Luigi Rigacci [Italie] ; Alessandro Pulsoni [Italie] ; Morton Coleman [États-Unis] ; Eldad J. Dann [Israël] ; Livio Trentin [Italie] ; Olivier Casasnovas [France] ; Chiara Rusconi [Italie] ; Pauline Brice [France] ; Silvia Bolis [Italie] ; Simonetta Viviani [Italie] ; Flavia Salvi [Italie] ; Stefano Luminari [Italie] ; Martin Hutchings [Danemark]Source :
- Haematologica [ 1592-8721 ] ; 2014.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Femelle, Fluorodésoxyglucose F18, Humains, Jeune adulte, Maladie de Hodgkin (), Maladie de Hodgkin (diagnostic), Maladie de Hodgkin (mortalité), Mâle, Pronostic, Reproductibilité des résultats, Résultat thérapeutique, Sensibilité et spécificité, Stade de la tumeur, Sujet âgé, Sujet âgé de 80 ans ou plus, Tomographie par émission de positons, Études de suivi, Études rétrospectives.
- MESH :
- diagnostic : Maladie de Hodgkin.
- mortalité : Maladie de Hodgkin.
- Adolescent, Adulte, Adulte d'âge moyen, Femelle, Fluorodésoxyglucose F18, Humains, Jeune adulte, Maladie de Hodgkin, Mâle, Pronostic, Reproductibilité des résultats, Résultat thérapeutique, Sensibilité et spécificité, Stade de la tumeur, Sujet âgé, Sujet âgé de 80 ans ou plus, Tomographie par émission de positons, Études de suivi, Études rétrospectives.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Female, Fluorodeoxyglucose F18, Follow-Up Studies, Hodgkin Disease (diagnosis), Hodgkin Disease (mortality), Hodgkin Disease (therapy), Humans, Male, Middle Aged, Neoplasm Staging, Positron-Emission Tomography, Prognosis, Reproducibility of Results, Retrospective Studies, Sensitivity and Specificity, Treatment Outcome, Young Adult.
- MESH :
- chemical : Fluorodeoxyglucose F18.
- diagnosis : Hodgkin Disease.
- mortality : Hodgkin Disease.
- therapy : Hodgkin Disease.
- Adolescent, Adult, Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neoplasm Staging, Positron-Emission Tomography, Prognosis, Reproducibility of Results, Retrospective Studies, Sensitivity and Specificity, Treatment Outcome, Young Adult.
Abstract
A retrospective, international, multicenter study was undertaken to assess: (i) the prognostic role of 'interim' positron emission tomography performed during treatment with doxorubicin, bleomycin, vinblastine and dacarbazine in patients with Hodgkin lymphoma; and (ii) the reproducibility of the Deauville five-point scale for the interpretation of interim positron emission tomography scan. Two hundred and sixty patients with newly diagnosed Hodgkin lymphoma were enrolled. Fifty-three patients with early unfavorable and 207 with advanced-stage disease were treated with doxorubicin, bleomycin, vinblastine and dacarbazine ± involved-field or consolidation radiotherapy. Positron emission tomography scan was performed at baseline and after two cycles of chemotherapy. Treatment was not changed according to the results of the interim scan. An international panel of six expert reviewers independently reported the scans using the Deauville five-point scale, blinded to treatment outcome. Forty-five scans were scored as positive (17.3%) and 215 (82.7%) as negative. After a median follow up of 37.0 (2-110) months, 252 patients are alive and eight have died. The 3-year progression-free survival rate was 83% for the whole study population, 28% for patients with interim positive scans and 95% for patients with interim negative scans (P<0.0001). The sensitivity, specificity, and negative and positive predictive values of interim positron emission tomography scans for predicting treatment outcome were 0.73, 0.94, 0.94 and 0.73, respectively. Binary concordance amongst reviewers was good (Cohen's kappa 0.69-0.84). In conclusion, the prognostic role and validity of the Deauville five-point scale for interpretation of interim positron emission tomography scans have been confirmed by the present study.
DOI: 10.3324/haematol.2013.103218
PubMed: 24658820
Affiliations:
- Australie, Danemark, France, Israël, Italie, Pologne, Royaume-Uni, États-Unis
- Angleterre, Bourgogne, Bourgogne-Franche-Comté, Grand Londres, Latium, Lombardie, Victoria (État), État de New York, Île-de-France
- Dijon, Londres, Melbourne, Milan, Paris, Rome
- Université de Melbourne
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Hofman</name><affiliation wicri:level="3"><nlm:affiliation>Center for Cancer Imaging Peter Mac Callum Cancer Center, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Center for Cancer Imaging Peter Mac Callum Cancer Center, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Rigacci, Luigi" sort="Rigacci, Luigi" uniqKey="Rigacci L" first="Luigi" last="Rigacci">Luigi Rigacci</name><affiliation wicri:level="1"><nlm:affiliation>Hematology Department, University of Florence, Careggi Hospital, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Hematology Department, University of Florence, Careggi Hospital</wicri:regionArea><wicri:noRegion>Careggi Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Pulsoni, Alessandro" sort="Pulsoni, Alessandro" uniqKey="Pulsoni A" first="Alessandro" last="Pulsoni">Alessandro Pulsoni</name><affiliation wicri:level="3"><nlm:affiliation>Cellular Biotechnology and Hematology Department, Sapienza University, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Cellular Biotechnology and Hematology Department, Sapienza University, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Coleman, Morton" sort="Coleman, Morton" uniqKey="Coleman M" first="Morton" last="Coleman">Morton Coleman</name><affiliation wicri:level="2"><nlm:affiliation>Hematology-Oncology Division, Center for Lymphoma & Myeloma, Weill Cornell Medical Center, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Hematology-Oncology Division, Center for Lymphoma & Myeloma, Weill Cornell Medical Center, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Dann, Eldad J" sort="Dann, Eldad J" uniqKey="Dann E" first="Eldad J" last="Dann">Eldad J. Dann</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematology & Bone Marrow Transplantation; Rambam Medical Center, Haifa, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Hematology & Bone Marrow Transplantation; Rambam Medical Center, Haifa</wicri:regionArea><wicri:noRegion>Haifa</wicri:noRegion></affiliation></author><author><name sortKey="Trentin, Livio" sort="Trentin, Livio" uniqKey="Trentin L" first="Livio" last="Trentin">Livio Trentin</name><affiliation wicri:level="1"><nlm:affiliation>Hematology Department, University of Padua, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Hematology Department, University of Padua</wicri:regionArea><wicri:noRegion>University of Padua</wicri:noRegion></affiliation></author><author><name sortKey="Casasnovas, Olivier" sort="Casasnovas, Olivier" uniqKey="Casasnovas O" first="Olivier" last="Casasnovas">Olivier Casasnovas</name><affiliation wicri:level="3"><nlm:affiliation>Hematology Department, Hopital Le Bocage, Dijon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hematology Department, Hopital Le Bocage, Dijon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Rusconi, Chiara" sort="Rusconi, Chiara" uniqKey="Rusconi C" first="Chiara" last="Rusconi">Chiara Rusconi</name><affiliation wicri:level="3"><nlm:affiliation>Hematology Department - Niguarda Ca' Granda Hospital, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Hematology Department - Niguarda Ca' Granda Hospital, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Brice, Pauline" sort="Brice, Pauline" uniqKey="Brice P" first="Pauline" last="Brice">Pauline Brice</name><affiliation wicri:level="3"><nlm:affiliation>Hematology Department Centre Hospitalier Universitaire St. Louis, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hematology Department Centre Hospitalier Universitaire St. Louis, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bolis, Silvia" sort="Bolis, Silvia" uniqKey="Bolis S" first="Silvia" last="Bolis">Silvia Bolis</name><affiliation wicri:level="1"><nlm:affiliation>Hematology Department, S. Gerardo University Hospital, Monza, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Hematology Department, S. Gerardo University Hospital, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Viviani, Simonetta" sort="Viviani, Simonetta" uniqKey="Viviani S" first="Simonetta" last="Viviani">Simonetta Viviani</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Salvi, Flavia" sort="Salvi, Flavia" uniqKey="Salvi F" first="Flavia" last="Salvi">Flavia Salvi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematology, SS Antonio e Biagio Hospital, Alessandria, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Hematology, SS Antonio e Biagio Hospital, Alessandria</wicri:regionArea><wicri:noRegion>Alessandria</wicri:noRegion></affiliation></author><author><name sortKey="Luminari, Stefano" sort="Luminari, Stefano" uniqKey="Luminari S" first="Stefano" last="Luminari">Stefano Luminari</name><affiliation wicri:level="1"><nlm:affiliation>Onco-Hematology Department, Modena University, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Onco-Hematology Department, Modena University</wicri:regionArea><wicri:noRegion>Modena University</wicri:noRegion></affiliation></author><author><name sortKey="Hutchings, Martin" sort="Hutchings, Martin" uniqKey="Hutchings M" first="Martin" last="Hutchings">Martin Hutchings</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Hematology, Rigshospitalet, Copenhagen University Hospital</wicri:regionArea><wicri:noRegion>Copenhagen University Hospital</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24658820</idno><idno type="pmid">24658820</idno><idno type="doi">10.3324/haematol.2013.103218</idno><idno type="wicri:Area/PubMed/Corpus">003749</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003749</idno><idno type="wicri:Area/PubMed/Curation">003635</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003635</idno><idno type="wicri:Area/PubMed/Checkpoint">003635</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003635</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The predictive role of interim positron emission tomography for Hodgkin lymphoma treatment outcome is confirmed using the interpretation criteria of the Deauville five-point scale.</title><author><name sortKey="Gallamini, Andrea" sort="Gallamini, Andrea" uniqKey="Gallamini A" first="Andrea" last="Gallamini">Andrea Gallamini</name><affiliation wicri:level="1"><nlm:affiliation>Research and Medical Innovation Department, Centre Antoine Lacassagne, Nice, France gallamini.a@ospedale.cuneo.it.</nlm:affiliation><country wicri:rule="url">Italie</country><wicri:regionArea>Research and Medical Innovation Department, Centre Antoine Lacassagne, Nice</wicri:regionArea><wicri:noRegion>Nice</wicri:noRegion></affiliation></author><author><name sortKey="Barrington, Sally F" sort="Barrington, Sally F" uniqKey="Barrington S" first="Sally F" last="Barrington">Sally F. Barrington</name><affiliation wicri:level="3"><nlm:affiliation>Division of Imaging, King's College London, PET Centre, Guy's & St. Thomas' Hospital, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Imaging, King's College London, PET Centre, Guy's & St. Thomas' Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Biggi, Alberto" sort="Biggi, Alberto" uniqKey="Biggi A" first="Alberto" last="Biggi">Alberto Biggi</name><affiliation wicri:level="1"><nlm:affiliation>Nuclear Medicine Department, PET Center, Azienda Ospedaliera S. Croce e Carle, Cuneo, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Nuclear Medicine Department, PET Center, Azienda Ospedaliera S. Croce e Carle, Cuneo</wicri:regionArea><wicri:noRegion>Cuneo</wicri:noRegion></affiliation></author><author><name sortKey="Chauvie, Stephane" sort="Chauvie, Stephane" uniqKey="Chauvie S" first="Stephane" last="Chauvie">Stephane Chauvie</name><affiliation wicri:level="1"><nlm:affiliation>Medical Physics Unit, Azienda Ospedaliera S. Croce e Carle, Cuneo, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Medical Physics Unit, Azienda Ospedaliera S. Croce e Carle, Cuneo</wicri:regionArea><wicri:noRegion>Cuneo</wicri:noRegion></affiliation></author><author><name sortKey="Kostakoglu, Lale" sort="Kostakoglu, Lale" uniqKey="Kostakoglu L" first="Lale" last="Kostakoglu">Lale Kostakoglu</name><affiliation wicri:level="2"><nlm:affiliation>Department of Radiology, Division of Nuclear Medicine, Mount Sinai Medical Center, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, Division of Nuclear Medicine, Mount Sinai Medical Center, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Gregianin, Michele" sort="Gregianin, Michele" uniqKey="Gregianin M" first="Michele" last="Gregianin">Michele Gregianin</name><affiliation wicri:level="1"><nlm:affiliation>Radiotherapy and Nuclear Medicine Unit, Istituto Oncologico Veneto IOV-IRCCS, Padua, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Radiotherapy and Nuclear Medicine Unit, Istituto Oncologico Veneto IOV-IRCCS, Padua</wicri:regionArea><wicri:noRegion>Padua</wicri:noRegion></affiliation></author><author><name sortKey="Meignan, Michel" sort="Meignan, Michel" uniqKey="Meignan M" first="Michel" last="Meignan">Michel Meignan</name><affiliation wicri:level="3"><nlm:affiliation>Nuclear Medicine Department, Centre Universitaire Hospitalier Henri Mondor, Creteril, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Nuclear Medicine Department, Centre Universitaire Hospitalier Henri Mondor, Creteril, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Mikhaeel, George N" sort="Mikhaeel, George N" uniqKey="Mikhaeel G" first="George N" last="Mikhaeel">George N. Mikhaeel</name><affiliation wicri:level="3"><nlm:affiliation>Clinical Oncology Department. Guy's & St. Thomas' Hospital, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Oncology Department. Guy's & St. Thomas' Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Loft, Annika" sort="Loft, Annika" uniqKey="Loft A" first="Annika" last="Loft">Annika Loft</name><affiliation wicri:level="1"><nlm:affiliation>PET & Cyclotron Unit, Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, Copenhagen University Hospital, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>PET & Cyclotron Unit, Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, Copenhagen University Hospital</wicri:regionArea><wicri:noRegion>Copenhagen University Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Zaucha, Jan M" sort="Zaucha, Jan M" uniqKey="Zaucha J" first="Jan M" last="Zaucha">Jan M. Zaucha</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, Gdynia Oncology Centre & Department of Propedeutic Oncology, University of Gdansk, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Oncology, Gdynia Oncology Centre & Department of Propedeutic Oncology, University of Gdansk</wicri:regionArea><wicri:noRegion>University of Gdansk</wicri:noRegion></affiliation></author><author><name sortKey="Seymour, John F" sort="Seymour, John F" uniqKey="Seymour J" first="John F" last="Seymour">John F. Seymour</name><affiliation wicri:level="4"><nlm:affiliation>Haematology Department, Peter MacCallum Cancer Centre, Melbourne, and University of Melbourne, Parkville Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Haematology Department, Peter MacCallum Cancer Centre, Melbourne, and University of Melbourne, Parkville Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Hofman, Michael S" sort="Hofman, Michael S" uniqKey="Hofman M" first="Michael S" last="Hofman">Michael S. Hofman</name><affiliation wicri:level="3"><nlm:affiliation>Center for Cancer Imaging Peter Mac Callum Cancer Center, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Center for Cancer Imaging Peter Mac Callum Cancer Center, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Rigacci, Luigi" sort="Rigacci, Luigi" uniqKey="Rigacci L" first="Luigi" last="Rigacci">Luigi Rigacci</name><affiliation wicri:level="1"><nlm:affiliation>Hematology Department, University of Florence, Careggi Hospital, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Hematology Department, University of Florence, Careggi Hospital</wicri:regionArea><wicri:noRegion>Careggi Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Pulsoni, Alessandro" sort="Pulsoni, Alessandro" uniqKey="Pulsoni A" first="Alessandro" last="Pulsoni">Alessandro Pulsoni</name><affiliation wicri:level="3"><nlm:affiliation>Cellular Biotechnology and Hematology Department, Sapienza University, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Cellular Biotechnology and Hematology Department, Sapienza University, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Coleman, Morton" sort="Coleman, Morton" uniqKey="Coleman M" first="Morton" last="Coleman">Morton Coleman</name><affiliation wicri:level="2"><nlm:affiliation>Hematology-Oncology Division, Center for Lymphoma & Myeloma, Weill Cornell Medical Center, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Hematology-Oncology Division, Center for Lymphoma & Myeloma, Weill Cornell Medical Center, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Dann, Eldad J" sort="Dann, Eldad J" uniqKey="Dann E" first="Eldad J" last="Dann">Eldad J. Dann</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematology & Bone Marrow Transplantation; Rambam Medical Center, Haifa, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Hematology & Bone Marrow Transplantation; Rambam Medical Center, Haifa</wicri:regionArea><wicri:noRegion>Haifa</wicri:noRegion></affiliation></author><author><name sortKey="Trentin, Livio" sort="Trentin, Livio" uniqKey="Trentin L" first="Livio" last="Trentin">Livio Trentin</name><affiliation wicri:level="1"><nlm:affiliation>Hematology Department, University of Padua, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Hematology Department, University of Padua</wicri:regionArea><wicri:noRegion>University of Padua</wicri:noRegion></affiliation></author><author><name sortKey="Casasnovas, Olivier" sort="Casasnovas, Olivier" uniqKey="Casasnovas O" first="Olivier" last="Casasnovas">Olivier Casasnovas</name><affiliation wicri:level="3"><nlm:affiliation>Hematology Department, Hopital Le Bocage, Dijon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hematology Department, Hopital Le Bocage, Dijon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Rusconi, Chiara" sort="Rusconi, Chiara" uniqKey="Rusconi C" first="Chiara" last="Rusconi">Chiara Rusconi</name><affiliation wicri:level="3"><nlm:affiliation>Hematology Department - Niguarda Ca' Granda Hospital, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Hematology Department - Niguarda Ca' Granda Hospital, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Brice, Pauline" sort="Brice, Pauline" uniqKey="Brice P" first="Pauline" last="Brice">Pauline Brice</name><affiliation wicri:level="3"><nlm:affiliation>Hematology Department Centre Hospitalier Universitaire St. Louis, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hematology Department Centre Hospitalier Universitaire St. Louis, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bolis, Silvia" sort="Bolis, Silvia" uniqKey="Bolis S" first="Silvia" last="Bolis">Silvia Bolis</name><affiliation wicri:level="1"><nlm:affiliation>Hematology Department, S. Gerardo University Hospital, Monza, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Hematology Department, S. Gerardo University Hospital, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Viviani, Simonetta" sort="Viviani, Simonetta" uniqKey="Viviani S" first="Simonetta" last="Viviani">Simonetta Viviani</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Salvi, Flavia" sort="Salvi, Flavia" uniqKey="Salvi F" first="Flavia" last="Salvi">Flavia Salvi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematology, SS Antonio e Biagio Hospital, Alessandria, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Hematology, SS Antonio e Biagio Hospital, Alessandria</wicri:regionArea><wicri:noRegion>Alessandria</wicri:noRegion></affiliation></author><author><name sortKey="Luminari, Stefano" sort="Luminari, Stefano" uniqKey="Luminari S" first="Stefano" last="Luminari">Stefano Luminari</name><affiliation wicri:level="1"><nlm:affiliation>Onco-Hematology Department, Modena University, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Onco-Hematology Department, Modena University</wicri:regionArea><wicri:noRegion>Modena University</wicri:noRegion></affiliation></author><author><name sortKey="Hutchings, Martin" sort="Hutchings, Martin" uniqKey="Hutchings M" first="Martin" last="Hutchings">Martin Hutchings</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Hematology, Rigshospitalet, Copenhagen University Hospital</wicri:regionArea><wicri:noRegion>Copenhagen University Hospital</wicri:noRegion></affiliation></author></analytic><series><title level="j">Haematologica</title><idno type="eISSN">1592-8721</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Fluorodeoxyglucose F18</term><term>Follow-Up Studies</term><term>Hodgkin Disease (diagnosis)</term><term>Hodgkin Disease (mortality)</term><term>Hodgkin Disease (therapy)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neoplasm Staging</term><term>Positron-Emission Tomography</term><term>Prognosis</term><term>Reproducibility of Results</term><term>Retrospective Studies</term><term>Sensitivity and Specificity</term><term>Treatment Outcome</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Fluorodésoxyglucose F18</term><term>Humains</term><term>Jeune adulte</term><term>Maladie de Hodgkin ()</term><term>Maladie de Hodgkin (diagnostic)</term><term>Maladie de Hodgkin (mortalité)</term><term>Mâle</term><term>Pronostic</term><term>Reproductibilité des résultats</term><term>Résultat thérapeutique</term><term>Sensibilité et spécificité</term><term>Stade de la tumeur</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tomographie par émission de positons</term><term>Études de suivi</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Fluorodeoxyglucose F18</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hodgkin Disease</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Maladie de Hodgkin</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Hodgkin Disease</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Maladie de Hodgkin</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Hodgkin Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neoplasm Staging</term><term>Positron-Emission Tomography</term><term>Prognosis</term><term>Reproducibility of Results</term><term>Retrospective Studies</term><term>Sensitivity and Specificity</term><term>Treatment Outcome</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Fluorodésoxyglucose F18</term><term>Humains</term><term>Jeune adulte</term><term>Maladie de Hodgkin</term><term>Mâle</term><term>Pronostic</term><term>Reproductibilité des résultats</term><term>Résultat thérapeutique</term><term>Sensibilité et spécificité</term><term>Stade de la tumeur</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tomographie par émission de positons</term><term>Études de suivi</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A retrospective, international, multicenter study was undertaken to assess: (i) the prognostic role of 'interim' positron emission tomography performed during treatment with doxorubicin, bleomycin, vinblastine and dacarbazine in patients with Hodgkin lymphoma; and (ii) the reproducibility of the Deauville five-point scale for the interpretation of interim positron emission tomography scan. Two hundred and sixty patients with newly diagnosed Hodgkin lymphoma were enrolled. Fifty-three patients with early unfavorable and 207 with advanced-stage disease were treated with doxorubicin, bleomycin, vinblastine and dacarbazine ± involved-field or consolidation radiotherapy. Positron emission tomography scan was performed at baseline and after two cycles of chemotherapy. Treatment was not changed according to the results of the interim scan. An international panel of six expert reviewers independently reported the scans using the Deauville five-point scale, blinded to treatment outcome. Forty-five scans were scored as positive (17.3%) and 215 (82.7%) as negative. After a median follow up of 37.0 (2-110) months, 252 patients are alive and eight have died. The 3-year progression-free survival rate was 83% for the whole study population, 28% for patients with interim positive scans and 95% for patients with interim negative scans (P<0.0001). The sensitivity, specificity, and negative and positive predictive values of interim positron emission tomography scans for predicting treatment outcome were 0.73, 0.94, 0.94 and 0.73, respectively. Binary concordance amongst reviewers was good (Cohen's kappa 0.69-0.84). In conclusion, the prognostic role and validity of the Deauville five-point scale for interpretation of interim positron emission tomography scans have been confirmed by the present study.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24658820</PMID><DateCreated><Year>2014</Year><Month>06</Month><Day>02</Day></DateCreated><DateCompleted><Year>2015</Year><Month>04</Month><Day>13</Day></DateCompleted><DateRevised><Year>2016</Year><Month>12</Month><Day>15</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1592-8721</ISSN><JournalIssue CitedMedium="Internet"><Volume>99</Volume><Issue>6</Issue><PubDate><Year>2014</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Haematologica</Title><ISOAbbreviation>Haematologica</ISOAbbreviation></Journal><ArticleTitle>The predictive role of interim positron emission tomography for Hodgkin lymphoma treatment outcome is confirmed using the interpretation criteria of the Deauville five-point scale.</ArticleTitle><Pagination><MedlinePgn>1107-13</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3324/haematol.2013.103218</ELocationID><Abstract><AbstractText>A retrospective, international, multicenter study was undertaken to assess: (i) the prognostic role of 'interim' positron emission tomography performed during treatment with doxorubicin, bleomycin, vinblastine and dacarbazine in patients with Hodgkin lymphoma; and (ii) the reproducibility of the Deauville five-point scale for the interpretation of interim positron emission tomography scan. Two hundred and sixty patients with newly diagnosed Hodgkin lymphoma were enrolled. Fifty-three patients with early unfavorable and 207 with advanced-stage disease were treated with doxorubicin, bleomycin, vinblastine and dacarbazine ± involved-field or consolidation radiotherapy. Positron emission tomography scan was performed at baseline and after two cycles of chemotherapy. Treatment was not changed according to the results of the interim scan. An international panel of six expert reviewers independently reported the scans using the Deauville five-point scale, blinded to treatment outcome. Forty-five scans were scored as positive (17.3%) and 215 (82.7%) as negative. After a median follow up of 37.0 (2-110) months, 252 patients are alive and eight have died. The 3-year progression-free survival rate was 83% for the whole study population, 28% for patients with interim positive scans and 95% for patients with interim negative scans (P<0.0001). The sensitivity, specificity, and negative and positive predictive values of interim positron emission tomography scans for predicting treatment outcome were 0.73, 0.94, 0.94 and 0.73, respectively. Binary concordance amongst reviewers was good (Cohen's kappa 0.69-0.84). In conclusion, the prognostic role and validity of the Deauville five-point scale for interpretation of interim positron emission tomography scans have been confirmed by the present study.</AbstractText><CopyrightInformation>Copyright© Ferrata Storti Foundation.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gallamini</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Research and Medical Innovation Department, Centre Antoine Lacassagne, Nice, France gallamini.a@ospedale.cuneo.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barrington</LastName><ForeName>Sally F</ForeName><Initials>SF</Initials><AffiliationInfo><Affiliation>Division of Imaging, King's College London, PET Centre, Guy's & St. Thomas' Hospital, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Biggi</LastName><ForeName>Alberto</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Nuclear Medicine Department, PET Center, Azienda Ospedaliera S. Croce e Carle, Cuneo, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chauvie</LastName><ForeName>Stephane</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Medical Physics Unit, Azienda Ospedaliera S. Croce e Carle, Cuneo, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kostakoglu</LastName><ForeName>Lale</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Radiology, Division of Nuclear Medicine, Mount Sinai Medical Center, New York, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gregianin</LastName><ForeName>Michele</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Radiotherapy and Nuclear Medicine Unit, Istituto Oncologico Veneto IOV-IRCCS, Padua, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meignan</LastName><ForeName>Michel</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Nuclear Medicine Department, Centre Universitaire Hospitalier Henri Mondor, Creteril, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mikhaeel</LastName><ForeName>George N</ForeName><Initials>GN</Initials><AffiliationInfo><Affiliation>Clinical Oncology Department. Guy's & St. Thomas' Hospital, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Loft</LastName><ForeName>Annika</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>PET & Cyclotron Unit, Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, Copenhagen University Hospital, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zaucha</LastName><ForeName>Jan M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Oncology, Gdynia Oncology Centre & Department of Propedeutic Oncology, University of Gdansk, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seymour</LastName><ForeName>John F</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Haematology Department, Peter MacCallum Cancer Centre, Melbourne, and University of Melbourne, Parkville Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hofman</LastName><ForeName>Michael S</ForeName><Initials>MS</Initials><AffiliationInfo><Affiliation>Center for Cancer Imaging Peter Mac Callum Cancer Center, Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rigacci</LastName><ForeName>Luigi</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Hematology Department, University of Florence, Careggi Hospital, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pulsoni</LastName><ForeName>Alessandro</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Cellular Biotechnology and Hematology Department, Sapienza University, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Coleman</LastName><ForeName>Morton</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Hematology-Oncology Division, Center for Lymphoma & Myeloma, Weill Cornell Medical Center, New York, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dann</LastName><ForeName>Eldad J</ForeName><Initials>EJ</Initials><AffiliationInfo><Affiliation>Department of Hematology & Bone Marrow Transplantation; Rambam Medical Center, Haifa, Israel.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Trentin</LastName><ForeName>Livio</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Hematology Department, University of Padua, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Casasnovas</LastName><ForeName>Olivier</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Hematology Department, Hopital Le Bocage, Dijon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rusconi</LastName><ForeName>Chiara</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Hematology Department - Niguarda Ca' Granda Hospital, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brice</LastName><ForeName>Pauline</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Hematology Department Centre Hospitalier Universitaire St. Louis, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bolis</LastName><ForeName>Silvia</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Hematology Department, S. Gerardo University Hospital, Monza, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Viviani</LastName><ForeName>Simonetta</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Salvi</LastName><ForeName>Flavia</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Hematology, SS Antonio e Biagio Hospital, Alessandria, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Luminari</LastName><ForeName>Stefano</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Onco-Hematology Department, Modena University, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hutchings</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Denmark.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>03</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>Italy</Country><MedlineTA>Haematologica</MedlineTA><NlmUniqueID>0417435</NlmUniqueID><ISSNLinking>0390-6078</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0Z5B2CJX4D</RegistryNumber><NameOfSubstance UI="D019788">Fluorodeoxyglucose F18</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>J Clin Oncol. 1989 Nov;7(11):1630-6</RefSource><PMID Version="1">2809679</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cancer Chemother Rep. 1966 Mar;50(3):163-70</RefSource><PMID 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Version="1">8622055</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019788" MajorTopicYN="N">Fluorodeoxyglucose F18</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006689" MajorTopicYN="N">Hodgkin Disease</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009367" MajorTopicYN="N">Neoplasm Staging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D049268" MajorTopicYN="Y">Positron-Emission Tomography</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015203" MajorTopicYN="N">Reproducibility of Results</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012680" MajorTopicYN="N">Sensitivity and Specificity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4040916</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>3</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>3</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>4</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24658820</ArticleId><ArticleId IdType="pii">haematol.2013.103218</ArticleId><ArticleId IdType="doi">10.3324/haematol.2013.103218</ArticleId><ArticleId IdType="pmc">PMC4040916</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>Danemark</li><li>France</li><li>Israël</li><li>Italie</li><li>Pologne</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Bourgogne</li><li>Bourgogne-Franche-Comté</li><li>Grand Londres</li><li>Latium</li><li>Lombardie</li><li>Victoria (État)</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Dijon</li><li>Londres</li><li>Melbourne</li><li>Milan</li><li>Paris</li><li>Rome</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><country name="Italie"><noRegion><name sortKey="Gallamini, Andrea" sort="Gallamini, Andrea" uniqKey="Gallamini A" first="Andrea" last="Gallamini">Andrea Gallamini</name></noRegion><name sortKey="Biggi, Alberto" sort="Biggi, Alberto" uniqKey="Biggi A" first="Alberto" last="Biggi">Alberto Biggi</name><name sortKey="Bolis, Silvia" sort="Bolis, Silvia" uniqKey="Bolis S" first="Silvia" last="Bolis">Silvia Bolis</name><name sortKey="Chauvie, Stephane" sort="Chauvie, Stephane" uniqKey="Chauvie S" first="Stephane" last="Chauvie">Stephane Chauvie</name><name sortKey="Gregianin, Michele" sort="Gregianin, Michele" uniqKey="Gregianin M" first="Michele" last="Gregianin">Michele Gregianin</name><name sortKey="Luminari, Stefano" sort="Luminari, Stefano" uniqKey="Luminari S" first="Stefano" last="Luminari">Stefano Luminari</name><name sortKey="Pulsoni, Alessandro" sort="Pulsoni, Alessandro" uniqKey="Pulsoni A" first="Alessandro" last="Pulsoni">Alessandro Pulsoni</name><name sortKey="Rigacci, Luigi" sort="Rigacci, Luigi" uniqKey="Rigacci L" first="Luigi" last="Rigacci">Luigi Rigacci</name><name sortKey="Rusconi, Chiara" sort="Rusconi, Chiara" uniqKey="Rusconi C" first="Chiara" last="Rusconi">Chiara Rusconi</name><name sortKey="Salvi, Flavia" sort="Salvi, Flavia" uniqKey="Salvi F" first="Flavia" last="Salvi">Flavia Salvi</name><name sortKey="Trentin, Livio" sort="Trentin, Livio" uniqKey="Trentin L" first="Livio" last="Trentin">Livio Trentin</name><name sortKey="Viviani, Simonetta" sort="Viviani, Simonetta" uniqKey="Viviani S" first="Simonetta" last="Viviani">Simonetta Viviani</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Barrington, Sally F" sort="Barrington, Sally F" uniqKey="Barrington S" first="Sally F" last="Barrington">Sally F. Barrington</name></region><name sortKey="Mikhaeel, George N" sort="Mikhaeel, George N" uniqKey="Mikhaeel G" first="George N" last="Mikhaeel">George N. Mikhaeel</name></country><country name="États-Unis"><region name="État de New York"><name sortKey="Kostakoglu, Lale" sort="Kostakoglu, Lale" uniqKey="Kostakoglu L" first="Lale" last="Kostakoglu">Lale Kostakoglu</name></region><name sortKey="Coleman, Morton" sort="Coleman, Morton" uniqKey="Coleman M" first="Morton" last="Coleman">Morton Coleman</name></country><country name="France"><region name="Île-de-France"><name sortKey="Meignan, Michel" sort="Meignan, Michel" uniqKey="Meignan M" first="Michel" last="Meignan">Michel Meignan</name></region><name sortKey="Brice, Pauline" sort="Brice, Pauline" uniqKey="Brice P" first="Pauline" last="Brice">Pauline Brice</name><name sortKey="Casasnovas, Olivier" sort="Casasnovas, Olivier" uniqKey="Casasnovas O" first="Olivier" last="Casasnovas">Olivier Casasnovas</name></country><country name="Danemark"><noRegion><name sortKey="Loft, Annika" sort="Loft, Annika" uniqKey="Loft A" first="Annika" last="Loft">Annika Loft</name></noRegion><name sortKey="Hutchings, Martin" sort="Hutchings, Martin" uniqKey="Hutchings M" first="Martin" last="Hutchings">Martin Hutchings</name></country><country name="Pologne"><noRegion><name sortKey="Zaucha, Jan M" sort="Zaucha, Jan M" uniqKey="Zaucha J" first="Jan M" last="Zaucha">Jan M. Zaucha</name></noRegion></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Seymour, John F" sort="Seymour, John F" uniqKey="Seymour J" first="John F" last="Seymour">John F. Seymour</name></region><name sortKey="Hofman, Michael S" sort="Hofman, Michael S" uniqKey="Hofman M" first="Michael S" last="Hofman">Michael S. Hofman</name></country><country name="Israël"><noRegion><name sortKey="Dann, Eldad J" sort="Dann, Eldad J" uniqKey="Dann E" first="Eldad J" last="Dann">Eldad J. Dann</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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