Chronic erythropoietin treatment improves diet-induced glucose intolerance in rats.
Identifieur interne : 002E29 ( PubMed/Checkpoint ); précédent : 002E28; suivant : 002E30Chronic erythropoietin treatment improves diet-induced glucose intolerance in rats.
Auteurs : Corinne Caillaud [Australie] ; Mie Mechta [Australie] ; Heidi Ainge [Australie] ; Andreas N. Madsen ; Patricia Ruell [Australie] ; Emilie Mas [Australie] ; Catherine Bisbal [Australie] ; Jacques Mercier ; Stephen Twigg [Australie] ; Trevor A. Mori [Australie] ; David Simar [Australie] ; Romain Barrès [Australie]Source :
- The Journal of endocrinology [ 1479-6805 ] ; 2015.
Descripteurs français
- KwdFr :
- Alimentation riche en graisse (effets indésirables), Animaux, Glucose (métabolisme), Humains, Insuline (métabolisme), Intolérance au glucose (enzymologie), Intolérance au glucose (génétique), Intolérance au glucose (métabolisme), Muscles squelettiques (enzymologie), Muscles squelettiques (métabolisme), Mâle, Protéines du choc thermique HSP72 (génétique), Protéines du choc thermique HSP72 (métabolisme), Protéines proto-oncogènes c-akt (génétique), Protéines proto-oncogènes c-akt (métabolisme), Rat Sprague-Dawley, Rats, Récepteur érythropoïétine (génétique), Récepteur érythropoïétine (métabolisme), Souris, Stress oxydatif, Érythropoïétine (métabolisme).
- MESH :
- effets indésirables : Alimentation riche en graisse.
- enzymologie : Intolérance au glucose, Muscles squelettiques.
- génétique : Intolérance au glucose, Protéines du choc thermique HSP72, Protéines proto-oncogènes c-akt, Récepteur érythropoïétine.
- métabolisme : Glucose, Insuline, Intolérance au glucose, Muscles squelettiques, Protéines du choc thermique HSP72, Protéines proto-oncogènes c-akt, Récepteur érythropoïétine, Érythropoïétine.
- Animaux, Humains, Mâle, Rat Sprague-Dawley, Rats, Souris, Stress oxydatif.
English descriptors
- KwdEn :
- Animals, Diet, High-Fat (adverse effects), Erythropoietin (metabolism), Glucose (metabolism), Glucose Intolerance (enzymology), Glucose Intolerance (genetics), Glucose Intolerance (metabolism), HSP72 Heat-Shock Proteins (genetics), HSP72 Heat-Shock Proteins (metabolism), Humans, Insulin (metabolism), Male, Mice, Muscle, Skeletal (enzymology), Muscle, Skeletal (metabolism), Oxidative Stress, Proto-Oncogene Proteins c-akt (genetics), Proto-Oncogene Proteins c-akt (metabolism), Rats, Rats, Sprague-Dawley, Receptors, Erythropoietin (genetics), Receptors, Erythropoietin (metabolism).
- MESH :
- chemical , genetics : HSP72 Heat-Shock Proteins, Proto-Oncogene Proteins c-akt, Receptors, Erythropoietin.
- chemical , metabolism : Erythropoietin, Glucose, HSP72 Heat-Shock Proteins, Insulin, Proto-Oncogene Proteins c-akt, Receptors, Erythropoietin.
- adverse effects : Diet, High-Fat.
- enzymology : Glucose Intolerance, Muscle, Skeletal.
- genetics : Glucose Intolerance.
- metabolism : Glucose Intolerance, Muscle, Skeletal.
- Animals, Humans, Male, Mice, Oxidative Stress, Rats, Rats, Sprague-Dawley.
Abstract
Erythropoietin (EPO) ameliorates glucose metabolism through mechanisms not fully understood. In this study, we investigated the effect of EPO on glucose metabolism and insulin signaling in skeletal muscle. A 2-week EPO treatment of rats fed with a high-fat diet (HFD) improved fasting glucose levels and glucose tolerance, without altering total body weight or retroperitoneal fat mass. Concomitantly, EPO partially rescued insulin-stimulated AKT activation, reduced markers of oxidative stress, and restored heat-shock protein 72 expression in soleus muscles from HFD-fed rats. Incubation of skeletal muscle cell cultures with EPO failed to induce AKT phosphorylation and had no effect on glucose uptake or glycogen synthesis. We found that the EPO receptor gene was expressed in myotubes, but was undetectable in soleus. Together, our results indicate that EPO treatment improves glucose tolerance but does not directly activate the phosphorylation of AKT in muscle cells. We propose that the reduced systemic inflammation or oxidative stress that we observed after treatment with EPO could contribute to the improvement of whole-body glucose metabolism.
DOI: 10.1530/JOE-15-0010
PubMed: 25767056
Affiliations:
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pubmed:25767056Le document en format XML
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<author><name sortKey="Mercier, Jacques" sort="Mercier, Jacques" uniqKey="Mercier J" first="Jacques" last="Mercier">Jacques Mercier</name>
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<author><name sortKey="Barres, Romain" sort="Barres, Romain" uniqKey="Barres R" first="Romain" last="Barrès">Romain Barrès</name>
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<series><title level="j">The Journal of endocrinology</title>
<idno type="eISSN">1479-6805</idno>
<imprint><date when="2015" type="published">2015</date>
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<term>Diet, High-Fat (adverse effects)</term>
<term>Erythropoietin (metabolism)</term>
<term>Glucose (metabolism)</term>
<term>Glucose Intolerance (enzymology)</term>
<term>Glucose Intolerance (genetics)</term>
<term>Glucose Intolerance (metabolism)</term>
<term>HSP72 Heat-Shock Proteins (genetics)</term>
<term>HSP72 Heat-Shock Proteins (metabolism)</term>
<term>Humans</term>
<term>Insulin (metabolism)</term>
<term>Male</term>
<term>Mice</term>
<term>Muscle, Skeletal (enzymology)</term>
<term>Muscle, Skeletal (metabolism)</term>
<term>Oxidative Stress</term>
<term>Proto-Oncogene Proteins c-akt (genetics)</term>
<term>Proto-Oncogene Proteins c-akt (metabolism)</term>
<term>Rats</term>
<term>Rats, Sprague-Dawley</term>
<term>Receptors, Erythropoietin (genetics)</term>
<term>Receptors, Erythropoietin (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Alimentation riche en graisse (effets indésirables)</term>
<term>Animaux</term>
<term>Glucose (métabolisme)</term>
<term>Humains</term>
<term>Insuline (métabolisme)</term>
<term>Intolérance au glucose (enzymologie)</term>
<term>Intolérance au glucose (génétique)</term>
<term>Intolérance au glucose (métabolisme)</term>
<term>Muscles squelettiques (enzymologie)</term>
<term>Muscles squelettiques (métabolisme)</term>
<term>Mâle</term>
<term>Protéines du choc thermique HSP72 (génétique)</term>
<term>Protéines du choc thermique HSP72 (métabolisme)</term>
<term>Protéines proto-oncogènes c-akt (génétique)</term>
<term>Protéines proto-oncogènes c-akt (métabolisme)</term>
<term>Rat Sprague-Dawley</term>
<term>Rats</term>
<term>Récepteur érythropoïétine (génétique)</term>
<term>Récepteur érythropoïétine (métabolisme)</term>
<term>Souris</term>
<term>Stress oxydatif</term>
<term>Érythropoïétine (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>HSP72 Heat-Shock Proteins</term>
<term>Proto-Oncogene Proteins c-akt</term>
<term>Receptors, Erythropoietin</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Erythropoietin</term>
<term>Glucose</term>
<term>HSP72 Heat-Shock Proteins</term>
<term>Insulin</term>
<term>Proto-Oncogene Proteins c-akt</term>
<term>Receptors, Erythropoietin</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Diet, High-Fat</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Alimentation riche en graisse</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Intolérance au glucose</term>
<term>Muscles squelettiques</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Glucose Intolerance</term>
<term>Muscle, Skeletal</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Glucose Intolerance</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Intolérance au glucose</term>
<term>Protéines du choc thermique HSP72</term>
<term>Protéines proto-oncogènes c-akt</term>
<term>Récepteur érythropoïétine</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Glucose Intolerance</term>
<term>Muscle, Skeletal</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Glucose</term>
<term>Insuline</term>
<term>Intolérance au glucose</term>
<term>Muscles squelettiques</term>
<term>Protéines du choc thermique HSP72</term>
<term>Protéines proto-oncogènes c-akt</term>
<term>Récepteur érythropoïétine</term>
<term>Érythropoïétine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Humans</term>
<term>Male</term>
<term>Mice</term>
<term>Oxidative Stress</term>
<term>Rats</term>
<term>Rats, Sprague-Dawley</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Humains</term>
<term>Mâle</term>
<term>Rat Sprague-Dawley</term>
<term>Rats</term>
<term>Souris</term>
<term>Stress oxydatif</term>
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<front><div type="abstract" xml:lang="en">Erythropoietin (EPO) ameliorates glucose metabolism through mechanisms not fully understood. In this study, we investigated the effect of EPO on glucose metabolism and insulin signaling in skeletal muscle. A 2-week EPO treatment of rats fed with a high-fat diet (HFD) improved fasting glucose levels and glucose tolerance, without altering total body weight or retroperitoneal fat mass. Concomitantly, EPO partially rescued insulin-stimulated AKT activation, reduced markers of oxidative stress, and restored heat-shock protein 72 expression in soleus muscles from HFD-fed rats. Incubation of skeletal muscle cell cultures with EPO failed to induce AKT phosphorylation and had no effect on glucose uptake or glycogen synthesis. We found that the EPO receptor gene was expressed in myotubes, but was undetectable in soleus. Together, our results indicate that EPO treatment improves glucose tolerance but does not directly activate the phosphorylation of AKT in muscle cells. We propose that the reduced systemic inflammation or oxidative stress that we observed after treatment with EPO could contribute to the improvement of whole-body glucose metabolism.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25767056</PMID>
<DateCreated><Year>2015</Year>
<Month>05</Month>
<Day>09</Day>
</DateCreated>
<DateCompleted><Year>2015</Year>
<Month>08</Month>
<Day>10</Day>
</DateCompleted>
<DateRevised><Year>2015</Year>
<Month>05</Month>
<Day>09</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1479-6805</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>225</Volume>
<Issue>2</Issue>
<PubDate><Year>2015</Year>
<Month>May</Month>
</PubDate>
</JournalIssue>
<Title>The Journal of endocrinology</Title>
<ISOAbbreviation>J. Endocrinol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Chronic erythropoietin treatment improves diet-induced glucose intolerance in rats.</ArticleTitle>
<Pagination><MedlinePgn>77-88</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1530/JOE-15-0010</ELocationID>
<Abstract><AbstractText>Erythropoietin (EPO) ameliorates glucose metabolism through mechanisms not fully understood. In this study, we investigated the effect of EPO on glucose metabolism and insulin signaling in skeletal muscle. A 2-week EPO treatment of rats fed with a high-fat diet (HFD) improved fasting glucose levels and glucose tolerance, without altering total body weight or retroperitoneal fat mass. Concomitantly, EPO partially rescued insulin-stimulated AKT activation, reduced markers of oxidative stress, and restored heat-shock protein 72 expression in soleus muscles from HFD-fed rats. Incubation of skeletal muscle cell cultures with EPO failed to induce AKT phosphorylation and had no effect on glucose uptake or glycogen synthesis. We found that the EPO receptor gene was expressed in myotubes, but was undetectable in soleus. Together, our results indicate that EPO treatment improves glucose tolerance but does not directly activate the phosphorylation of AKT in muscle cells. We propose that the reduced systemic inflammation or oxidative stress that we observed after treatment with EPO could contribute to the improvement of whole-body glucose metabolism.</AbstractText>
<CopyrightInformation>© 2015 The authors.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Caillaud</LastName>
<ForeName>Corinne</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Exercise Health and Performance Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia Faculty of Health and Medical Sciences The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark Department of Neuroscience and Pharmacology Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark School of Medicine and Pharmacology Royal Perth Hospital, The University of Western Australia, Perth, Western Australia, Australia UMR CNRS 9214 U1046 INSERM Physiologie et Médecine Expérimentale du Cœur et des Muscles, Université de Montpellier, Montpellier, France Physiology Department CHU Arnaud de Villeneuve, Montpellier, France Department of Endocrinology Sydney Medical School, Royal Prince Alfred Hospital, University of Sydney, Camperdown, New South Wales, Australia Inflammation and Infection Research School of Medical Sciences, UNSW Australia, Sydney, New South Wales, Australia corinne.caillaud@sydney.edu.au barres@sund.ku.dk.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mechta</LastName>
<ForeName>Mie</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Exercise Health and Performance Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia Faculty of Health and Medical Sciences The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark Department of Neuroscience and Pharmacology Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark School of Medicine and Pharmacology Royal Perth Hospital, The University of Western Australia, Perth, Western Australia, Australia UMR CNRS 9214 U1046 INSERM Physiologie et Médecine Expérimentale du Cœur et des Muscles, Université de Montpellier, Montpellier, France Physiology Department CHU Arnaud de Villeneuve, Montpellier, France Department of Endocrinology Sydney Medical School, Royal Prince Alfred Hospital, University of Sydney, Camperdown, New South Wales, Australia Inflammation and Infection Research School of Medical Sciences, UNSW Australia, Sydney, New South Wales, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ainge</LastName>
<ForeName>Heidi</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Exercise Health and Performance Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia Faculty of Health and Medical Sciences The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark Department of Neuroscience and Pharmacology Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark School of Medicine and Pharmacology Royal Perth Hospital, The University of Western Australia, Perth, Western Australia, Australia UMR CNRS 9214 U1046 INSERM Physiologie et Médecine Expérimentale du Cœur et des Muscles, Université de Montpellier, Montpellier, France Physiology Department CHU Arnaud de Villeneuve, Montpellier, France Department of Endocrinology Sydney Medical School, Royal Prince Alfred Hospital, University of Sydney, Camperdown, New South Wales, Australia Inflammation and Infection Research School of Medical Sciences, UNSW Australia, Sydney, New South Wales, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Madsen</LastName>
<ForeName>Andreas N</ForeName>
<Initials>AN</Initials>
<AffiliationInfo><Affiliation>Exercise Health and Performance Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia Faculty of Health and Medical Sciences The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark Department of Neuroscience and Pharmacology Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark School of Medicine and Pharmacology Royal Perth Hospital, The University of Western Australia, Perth, Western Australia, Australia UMR CNRS 9214 U1046 INSERM Physiologie et Médecine Expérimentale du Cœur et des Muscles, Université de Montpellier, Montpellier, France Physiology Department CHU Arnaud de Villeneuve, Montpellier, France Department of Endocrinology Sydney Medical School, Royal Prince Alfred Hospital, University of Sydney, Camperdown, New South Wales, Australia Inflammation and Infection Research School of Medical Sciences, UNSW Australia, Sydney, New South Wales, Australia Exercise Health and Performance Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia Faculty of Health and Medical Sciences The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark Department of Neuroscience and Pharmacology Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark School of Medicine and Pharmacology Royal Perth Hospital, The University of Western Australia, Perth, Western Australia, Australia UMR CNRS 9214 U1046 INSERM Physiologie et Médecine Expérimentale du Cœur et des Muscles, Université de Montpellier, Montpellier, France Physiology Department CHU Arnaud de Villeneuve, Montpellier, France Department of Endocrinology Sydney Medical School, Royal Prince Alfred Hospital, University of Sydney, Camperdown, New South Wales, Australia Inflammation and Infection Research School of Medical Sciences, UNSW Australia, Sydney, N</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ruell</LastName>
<ForeName>Patricia</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Exercise Health and Performance Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia Faculty of Health and Medical Sciences The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark Department of Neuroscience and Pharmacology Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark School of Medicine and Pharmacology Royal Perth Hospital, The University of Western Australia, Perth, Western Australia, Australia UMR CNRS 9214 U1046 INSERM Physiologie et Médecine Expérimentale du Cœur et des Muscles, Université de Montpellier, Montpellier, France Physiology Department CHU Arnaud de Villeneuve, Montpellier, France Department of Endocrinology Sydney Medical School, Royal Prince Alfred Hospital, University of Sydney, Camperdown, New South Wales, Australia Inflammation and Infection Research School of Medical Sciences, UNSW Australia, Sydney, New South Wales, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mas</LastName>
<ForeName>Emilie</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Exercise Health and Performance Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia Faculty of Health and Medical Sciences The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark Department of Neuroscience and Pharmacology Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark School of Medicine and Pharmacology Royal Perth Hospital, The University of Western Australia, Perth, Western Australia, Australia UMR CNRS 9214 U1046 INSERM Physiologie et Médecine Expérimentale du Cœur et des Muscles, Université de Montpellier, Montpellier, France Physiology Department CHU Arnaud de Villeneuve, Montpellier, France Department of Endocrinology Sydney Medical School, Royal Prince Alfred Hospital, University of Sydney, Camperdown, New South Wales, Australia Inflammation and Infection Research School of Medical Sciences, UNSW Australia, Sydney, New South Wales, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bisbal</LastName>
<ForeName>Catherine</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Exercise Health and Performance Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia Faculty of Health and Medical Sciences The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark Department of Neuroscience and Pharmacology Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark School of Medicine and Pharmacology Royal Perth Hospital, The University of Western Australia, Perth, Western Australia, Australia UMR CNRS 9214 U1046 INSERM Physiologie et Médecine Expérimentale du Cœur et des Muscles, Université de Montpellier, Montpellier, France Physiology Department CHU Arnaud de Villeneuve, Montpellier, France Department of Endocrinology Sydney Medical School, Royal Prince Alfred Hospital, University of Sydney, Camperdown, New South Wales, Australia Inflammation and Infection Research School of Medical Sciences, UNSW Australia, Sydney, New South Wales, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mercier</LastName>
<ForeName>Jacques</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Exercise Health and Performance Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia Faculty of Health and Medical Sciences The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark Department of Neuroscience and Pharmacology Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark School of Medicine and Pharmacology Royal Perth Hospital, The University of Western Australia, Perth, Western Australia, Australia UMR CNRS 9214 U1046 INSERM Physiologie et Médecine Expérimentale du Cœur et des Muscles, Université de Montpellier, Montpellier, France Physiology Department CHU Arnaud de Villeneuve, Montpellier, France Department of Endocrinology Sydney Medical School, Royal Prince Alfred Hospital, University of Sydney, Camperdown, New South Wales, Australia Inflammation and Infection Research School of Medical Sciences, UNSW Australia, Sydney, New South Wales, Australia Exercise Health and Performance Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia Faculty of Health and Medical Sciences The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark Department of Neuroscience and Pharmacology Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark School of Medicine and Pharmacology Royal Perth Hospital, The University of Western Australia, Perth, Western Australia, Australia UMR CNRS 9214 U1046 INSERM Physiologie et Médecine Expérimentale du Cœur et des Muscles, Université de Montpellier, Montpellier, France Physiology Department CHU Arnaud de Villeneuve, Montpellier, France Department of Endocrinology Sydney Medical School, Royal Prince Alfred Hospital, University of Sydney, Camperdown, New South Wales, Australia Inflammation and Infection Research School of Medical Sciences, UNSW Australia, Sydney, N</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Twigg</LastName>
<ForeName>Stephen</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Exercise Health and Performance Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia Faculty of Health and Medical Sciences The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark Department of Neuroscience and Pharmacology Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark School of Medicine and Pharmacology Royal Perth Hospital, The University of Western Australia, Perth, Western Australia, Australia UMR CNRS 9214 U1046 INSERM Physiologie et Médecine Expérimentale du Cœur et des Muscles, Université de Montpellier, Montpellier, France Physiology Department CHU Arnaud de Villeneuve, Montpellier, France Department of Endocrinology Sydney Medical School, Royal Prince Alfred Hospital, University of Sydney, Camperdown, New South Wales, Australia Inflammation and Infection Research School of Medical Sciences, UNSW Australia, Sydney, New South Wales, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mori</LastName>
<ForeName>Trevor A</ForeName>
<Initials>TA</Initials>
<AffiliationInfo><Affiliation>Exercise Health and Performance Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia Faculty of Health and Medical Sciences The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark Department of Neuroscience and Pharmacology Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark School of Medicine and Pharmacology Royal Perth Hospital, The University of Western Australia, Perth, Western Australia, Australia UMR CNRS 9214 U1046 INSERM Physiologie et Médecine Expérimentale du Cœur et des Muscles, Université de Montpellier, Montpellier, France Physiology Department CHU Arnaud de Villeneuve, Montpellier, France Department of Endocrinology Sydney Medical School, Royal Prince Alfred Hospital, University of Sydney, Camperdown, New South Wales, Australia Inflammation and Infection Research School of Medical Sciences, UNSW Australia, Sydney, New South Wales, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Simar</LastName>
<ForeName>David</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Exercise Health and Performance Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia Faculty of Health and Medical Sciences The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark Department of Neuroscience and Pharmacology Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark School of Medicine and Pharmacology Royal Perth Hospital, The University of Western Australia, Perth, Western Australia, Australia UMR CNRS 9214 U1046 INSERM Physiologie et Médecine Expérimentale du Cœur et des Muscles, Université de Montpellier, Montpellier, France Physiology Department CHU Arnaud de Villeneuve, Montpellier, France Department of Endocrinology Sydney Medical School, Royal Prince Alfred Hospital, University of Sydney, Camperdown, New South Wales, Australia Inflammation and Infection Research School of Medical Sciences, UNSW Australia, Sydney, New South Wales, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Barrès</LastName>
<ForeName>Romain</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Exercise Health and Performance Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia Faculty of Health and Medical Sciences The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark Department of Neuroscience and Pharmacology Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark School of Medicine and Pharmacology Royal Perth Hospital, The University of Western Australia, Perth, Western Australia, Australia UMR CNRS 9214 U1046 INSERM Physiologie et Médecine Expérimentale du Cœur et des Muscles, Université de Montpellier, Montpellier, France Physiology Department CHU Arnaud de Villeneuve, Montpellier, France Department of Endocrinology Sydney Medical School, Royal Prince Alfred Hospital, University of Sydney, Camperdown, New South Wales, Australia Inflammation and Infection Research School of Medical Sciences, UNSW Australia, Sydney, New South Wales, Australia corinne.caillaud@sydney.edu.au barres@sund.ku.dk.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2015</Year>
<Month>03</Month>
<Day>12</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>J Endocrinol</MedlineTA>
<NlmUniqueID>0375363</NlmUniqueID>
<ISSNLinking>0022-0795</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D050884">HSP72 Heat-Shock Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D007328">Insulin</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D017467">Receptors, Erythropoietin</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>11096-26-7</RegistryNumber>
<NameOfSubstance UI="D004921">Erythropoietin</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber>
<NameOfSubstance UI="D051057">Proto-Oncogene Proteins c-akt</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>IY9XDZ35W2</RegistryNumber>
<NameOfSubstance UI="D005947">Glucose</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D059305" MajorTopicYN="N">Diet, High-Fat</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004921" MajorTopicYN="N">Erythropoietin</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005947" MajorTopicYN="N">Glucose</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018149" MajorTopicYN="N">Glucose Intolerance</DescriptorName>
<QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D050884" MajorTopicYN="N">HSP72 Heat-Shock Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007328" MajorTopicYN="N">Insulin</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018482" MajorTopicYN="N">Muscle, Skeletal</DescriptorName>
<QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018384" MajorTopicYN="N">Oxidative Stress</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051057" MajorTopicYN="N">Proto-Oncogene Proteins c-akt</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017207" MajorTopicYN="N">Rats, Sprague-Dawley</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017467" MajorTopicYN="N">Receptors, Erythropoietin</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">glucose metabolism</Keyword>
<Keyword MajorTopicYN="N">high-fat diet</Keyword>
<Keyword MajorTopicYN="N">myotubes</Keyword>
<Keyword MajorTopicYN="N">skeletal muscle</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="accepted"><Year>2015</Year>
<Month>03</Month>
<Day>12</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2015</Year>
<Month>3</Month>
<Day>14</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2015</Year>
<Month>3</Month>
<Day>15</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2015</Year>
<Month>8</Month>
<Day>11</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">25767056</ArticleId>
<ArticleId IdType="pii">JOE-15-0010</ArticleId>
<ArticleId IdType="doi">10.1530/JOE-15-0010</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Australie</li>
</country>
<region><li>Nouvelle-Galles du Sud</li>
</region>
<settlement><li>Sydney</li>
</settlement>
<orgName><li>Université de Sydney</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Madsen, Andreas N" sort="Madsen, Andreas N" uniqKey="Madsen A" first="Andreas N" last="Madsen">Andreas N. Madsen</name>
<name sortKey="Mercier, Jacques" sort="Mercier, Jacques" uniqKey="Mercier J" first="Jacques" last="Mercier">Jacques Mercier</name>
</noCountry>
<country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Caillaud, Corinne" sort="Caillaud, Corinne" uniqKey="Caillaud C" first="Corinne" last="Caillaud">Corinne Caillaud</name>
</region>
<name sortKey="Ainge, Heidi" sort="Ainge, Heidi" uniqKey="Ainge H" first="Heidi" last="Ainge">Heidi Ainge</name>
<name sortKey="Barres, Romain" sort="Barres, Romain" uniqKey="Barres R" first="Romain" last="Barrès">Romain Barrès</name>
<name sortKey="Bisbal, Catherine" sort="Bisbal, Catherine" uniqKey="Bisbal C" first="Catherine" last="Bisbal">Catherine Bisbal</name>
<name sortKey="Mas, Emilie" sort="Mas, Emilie" uniqKey="Mas E" first="Emilie" last="Mas">Emilie Mas</name>
<name sortKey="Mechta, Mie" sort="Mechta, Mie" uniqKey="Mechta M" first="Mie" last="Mechta">Mie Mechta</name>
<name sortKey="Mori, Trevor A" sort="Mori, Trevor A" uniqKey="Mori T" first="Trevor A" last="Mori">Trevor A. Mori</name>
<name sortKey="Ruell, Patricia" sort="Ruell, Patricia" uniqKey="Ruell P" first="Patricia" last="Ruell">Patricia Ruell</name>
<name sortKey="Simar, David" sort="Simar, David" uniqKey="Simar D" first="David" last="Simar">David Simar</name>
<name sortKey="Twigg, Stephen" sort="Twigg, Stephen" uniqKey="Twigg S" first="Stephen" last="Twigg">Stephen Twigg</name>
</country>
</tree>
</affiliations>
</record>
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