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Criteria for dendritic cell receptor selection for efficient antibody-targeted vaccination.

Identifieur interne : 002D67 ( PubMed/Checkpoint ); précédent : 002D66; suivant : 002D68

Criteria for dendritic cell receptor selection for efficient antibody-targeted vaccination.

Auteurs : Anika Reuter [Allemagne] ; Scott E. Panozza [Australie] ; Christophe Macri [Australie] ; Claire Dumont [Australie] ; Jessica Li [Australie] ; Haiyin Liu [Australie] ; Elodie Segura [France] ; Javier Vega-Ramos [Australie] ; Nishma Gupta [Australie] ; Irina Caminschi [Australie] ; Jose A. Villadangos [Australie] ; Angus P R. Johnston [Australie] ; Justine D. Mintern [Australie]

Source :

Journal of immunology (Baltimore, Md. : 1950) [ 1550-6606 ] ; 2015.

RBID : pubmed:25653426

Descripteurs français

English descriptors

KwdEn :
- Animals, Antibodies (immunology), Antigen Presentation (immunology), Antigens, CD (immunology), Antigens, CD (metabolism), Antigens, CD11b (immunology), Antigens, CD11c (immunology), Antigens, CD40 (immunology), Cells, Cultured, Dendritic Cells (immunology), Dendritic Cells (metabolism), Endocytosis (immunology), Histocompatibility Antigens Class I (immunology), Histocompatibility Antigens Class II (immunology), Humans, Lectins, C-Type (immunology), Mice, Inbred C57BL, Mice, Knockout, Minor Histocompatibility Antigens, Receptors, Cell Surface (immunology), Receptors, Immunologic (immunology), Vaccination (methods), Vaccines (administration & dosage), Vaccines (immunology).
MESH :
- chemical , administration & dosage : Vaccines.
- chemical , immunology : Antibodies, Antigens, CD, Antigens, CD11b, Antigens, CD11c, Antigens, CD40, Histocompatibility Antigens Class I, Histocompatibility Antigens Class II, Lectins, C-Type, Receptors, Cell Surface, Receptors, Immunologic, Vaccines.
- immunology : Antigen Presentation, Dendritic Cells, Endocytosis.
- chemical , metabolism : Antigens, CD, Dendritic Cells.
- methods : Vaccination.
- Animals, Cells, Cultured, Humans, Mice, Inbred C57BL, Mice, Knockout, Minor Histocompatibility Antigens.

Abstract

Ab-targeted vaccination involves targeting a receptor of choice expressed by dendritic cells (DCs) with Ag-coupled Abs. Currently, there is little consensus as to which criteria determine receptor selection to ensure superior Ag presentation and immunity. In this study, we investigated parameters of DC receptor internalization and determined how they impact Ag presentation outcomes. First, using mixed bone marrow chimeras, we established that Ag-targeted, but not nontargeted, DCs are responsible for Ag presentation in settings of Ab-targeted vaccination in vivo. Next, we analyzed parameters of DEC205 (CD205), Clec9A, CD11c, CD11b, and CD40 endocytosis and obtained quantitative measurements of internalization speed, surface turnover, and delivered Ag load. Exploiting these parameters in MHC class I (MHC I) and MHC class II (MHC II) Ag presentation assays, we showed that receptor expression level, proportion of surface turnover, or speed of receptor internalization did not impact MHC I or MHC II Ag presentation efficiency. Furthermore, the Ag load delivered to DCs did not correlate with the efficiency of MHC I or MHC II Ag presentation. In contrast, targeting Ag to CD8(+) or CD8(-) DCs enhanced MHC I or MHC II Ag presentation, respectively. Therefore, receptor expression levels, speed of internalization, and/or the amount of Ag delivered can be excluded as major determinants that dictate Ag presentation efficiency in setting of Ab-targeted vaccination.

DOI: 10.4049/jimmunol.1402535
PubMed: 25653426

Affiliations:

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<author><name sortKey="Vega Ramos, Javier" sort="Vega Ramos, Javier" uniqKey="Vega Ramos J" first="Javier" last="Vega-Ramos">Javier Vega-Ramos</name>
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<author><name sortKey="Gupta, Nishma" sort="Gupta, Nishma" uniqKey="Gupta N" first="Nishma" last="Gupta">Nishma Gupta</name>
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<term>Antibodies (immunology)</term>
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<term>Antigens, CD (immunology)</term>
<term>Antigens, CD (metabolism)</term>
<term>Antigens, CD11b (immunology)</term>
<term>Antigens, CD11c (immunology)</term>
<term>Antigens, CD40 (immunology)</term>
<term>Cells, Cultured</term>
<term>Dendritic Cells (immunology)</term>
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<term>Endocytosis (immunology)</term>
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<term>Histocompatibility Antigens Class II (immunology)</term>
<term>Humans</term>
<term>Lectins, C-Type (immunology)</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Knockout</term>
<term>Minor Histocompatibility Antigens</term>
<term>Receptors, Cell Surface (immunology)</term>
<term>Receptors, Immunologic (immunology)</term>
<term>Vaccination (methods)</term>
<term>Vaccines (administration & dosage)</term>
<term>Vaccines (immunology)</term>
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<term>Antigènes CD40 (immunologie)</term>
<term>Antigènes d'histocompatibilité de classe I (immunologie)</term>
<term>Antigènes d'histocompatibilité de classe II (immunologie)</term>
<term>Antigènes mineurs d'histocompatibilité</term>
<term>Cellules cultivées</term>
<term>Cellules dendritiques (immunologie)</term>
<term>Cellules dendritiques (métabolisme)</term>
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<term>Humains</term>
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<term>Présentation d'antigène (immunologie)</term>
<term>Récepteurs de surface cellulaire (immunologie)</term>
<term>Récepteurs immunologiques (immunologie)</term>
<term>Souris de lignée C57BL</term>
<term>Souris knockout</term>
<term>Vaccination ()</term>
<term>Vaccins (administration et posologie)</term>
<term>Vaccins (immunologie)</term>
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<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies</term>
<term>Antigens, CD</term>
<term>Antigens, CD11b</term>
<term>Antigens, CD11c</term>
<term>Antigens, CD40</term>
<term>Histocompatibility Antigens Class I</term>
<term>Histocompatibility Antigens Class II</term>
<term>Lectins, C-Type</term>
<term>Receptors, Cell Surface</term>
<term>Receptors, Immunologic</term>
<term>Vaccines</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps</term>
<term>Antigènes CD</term>
<term>Antigènes CD11b</term>
<term>Antigènes CD11c</term>
<term>Antigènes CD40</term>
<term>Antigènes d'histocompatibilité de classe I</term>
<term>Antigènes d'histocompatibilité de classe II</term>
<term>Cellules dendritiques</term>
<term>Endocytose</term>
<term>Lectines de type C</term>
<term>Présentation d'antigène</term>
<term>Récepteurs de surface cellulaire</term>
<term>Récepteurs immunologiques</term>
<term>Vaccins</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Antigen Presentation</term>
<term>Dendritic Cells</term>
<term>Endocytosis</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antigens, CD</term>
<term>Dendritic Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Vaccination</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Antigènes CD</term>
<term>Cellules dendritiques</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cells, Cultured</term>
<term>Humans</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Knockout</term>
<term>Minor Histocompatibility Antigens</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Antigènes mineurs d'histocompatibilité</term>
<term>Cellules cultivées</term>
<term>Humains</term>
<term>Souris de lignée C57BL</term>
<term>Souris knockout</term>
<term>Vaccination</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en">Ab-targeted vaccination involves targeting a receptor of choice expressed by dendritic cells (DCs) with Ag-coupled Abs. Currently, there is little consensus as to which criteria determine receptor selection to ensure superior Ag presentation and immunity. In this study, we investigated parameters of DC receptor internalization and determined how they impact Ag presentation outcomes. First, using mixed bone marrow chimeras, we established that Ag-targeted, but not nontargeted, DCs are responsible for Ag presentation in settings of Ab-targeted vaccination in vivo. Next, we analyzed parameters of DEC205 (CD205), Clec9A, CD11c, CD11b, and CD40 endocytosis and obtained quantitative measurements of internalization speed, surface turnover, and delivered Ag load. Exploiting these parameters in MHC class I (MHC I) and MHC class II (MHC II) Ag presentation assays, we showed that receptor expression level, proportion of surface turnover, or speed of receptor internalization did not impact MHC I or MHC II Ag presentation efficiency. Furthermore, the Ag load delivered to DCs did not correlate with the efficiency of MHC I or MHC II Ag presentation. In contrast, targeting Ag to CD8(+) or CD8(-) DCs enhanced MHC I or MHC II Ag presentation, respectively. Therefore, receptor expression levels, speed of internalization, and/or the amount of Ag delivered can be excluded as major determinants that dictate Ag presentation efficiency in setting of Ab-targeted vaccination.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25653426</PMID>
<DateCreated><Year>2015</Year>
<Month>03</Month>
<Day>09</Day>
</DateCreated>
<DateCompleted><Year>2015</Year>
<Month>06</Month>
<Day>19</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>11</Month>
<Day>16</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1550-6606</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>194</Volume>
<Issue>6</Issue>
<PubDate><Year>2015</Year>
<Month>Mar</Month>
<Day>15</Day>
</PubDate>
</JournalIssue>
<Title>Journal of immunology (Baltimore, Md. : 1950)</Title>
<ISOAbbreviation>J. Immunol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Criteria for dendritic cell receptor selection for efficient antibody-targeted vaccination.</ArticleTitle>
<Pagination><MedlinePgn>2696-705</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.4049/jimmunol.1402535</ELocationID>
<Abstract><AbstractText>Ab-targeted vaccination involves targeting a receptor of choice expressed by dendritic cells (DCs) with Ag-coupled Abs. Currently, there is little consensus as to which criteria determine receptor selection to ensure superior Ag presentation and immunity. In this study, we investigated parameters of DC receptor internalization and determined how they impact Ag presentation outcomes. First, using mixed bone marrow chimeras, we established that Ag-targeted, but not nontargeted, DCs are responsible for Ag presentation in settings of Ab-targeted vaccination in vivo. Next, we analyzed parameters of DEC205 (CD205), Clec9A, CD11c, CD11b, and CD40 endocytosis and obtained quantitative measurements of internalization speed, surface turnover, and delivered Ag load. Exploiting these parameters in MHC class I (MHC I) and MHC class II (MHC II) Ag presentation assays, we showed that receptor expression level, proportion of surface turnover, or speed of receptor internalization did not impact MHC I or MHC II Ag presentation efficiency. Furthermore, the Ag load delivered to DCs did not correlate with the efficiency of MHC I or MHC II Ag presentation. In contrast, targeting Ag to CD8(+) or CD8(-) DCs enhanced MHC I or MHC II Ag presentation, respectively. Therefore, receptor expression levels, speed of internalization, and/or the amount of Ag delivered can be excluded as major determinants that dictate Ag presentation efficiency in setting of Ab-targeted vaccination.</AbstractText>
<CopyrightInformation>Copyright © 2015 by The American Association of Immunologists, Inc.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Reuter</LastName>
<ForeName>Anika</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia; Max Planck Graduate Center, 55128 Mainz, Germany; Institute of Physical Chemistry, 55099 Mainz, Germany;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Panozza</LastName>
<ForeName>Scott E</ForeName>
<Initials>SE</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Macri</LastName>
<ForeName>Christophe</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dumont</LastName>
<ForeName>Claire</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Jessica</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Centre for Immunology, Burnet Institute, Melbourne, Victoria 3004, Australia;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Haiyin</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Segura</LastName>
<ForeName>Elodie</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>INSERM Unité 932, 75248 Paris Cedex 05, France; Institut Curie, Centre de Recherche, 75248 Paris Cedex 05, France;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vega-Ramos</LastName>
<ForeName>Javier</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria 3010, Australia; and.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gupta</LastName>
<ForeName>Nishma</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia;</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Caminschi</LastName>
<ForeName>Irina</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Centre for Immunology, Burnet Institute, Melbourne, Victoria 3004, Australia; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria 3010, Australia; and.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Villadangos</LastName>
<ForeName>Jose A</ForeName>
<Initials>JA</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria 3010, Australia; and.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Johnston</LastName>
<ForeName>Angus P R</ForeName>
<Initials>AP</Initials>
<AffiliationInfo><Affiliation>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria 3052, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mintern</LastName>
<ForeName>Justine D</ForeName>
<Initials>JD</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia; jmintern@unimelb.edu.au angus.johnston@monash.edu.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2015</Year>
<Month>02</Month>
<Day>04</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Immunol</MedlineTA>
<NlmUniqueID>2985117R</NlmUniqueID>
<ISSNLinking>0022-1767</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000906">Antibodies</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015703">Antigens, CD</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D039481">Antigens, CD11b</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D039521">Antigens, CD11c</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D019013">Antigens, CD40</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C529914">Clec9a protein, mouse</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C093569">DEC-205 receptor</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015395">Histocompatibility Antigens Class I</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000949">Histocompatibility Antigens Class II</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D037181">Lectins, C-Type</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015778">Minor Histocompatibility Antigens</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D011956">Receptors, Cell Surface</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D011971">Receptors, Immunologic</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014612">Vaccines</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>AIM</CitationSubset>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000906" MajorTopicYN="N">Antibodies</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017951" MajorTopicYN="N">Antigen Presentation</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015703" MajorTopicYN="N">Antigens, CD</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D039481" MajorTopicYN="N">Antigens, CD11b</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D039521" MajorTopicYN="N">Antigens, CD11c</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019013" MajorTopicYN="N">Antigens, CD40</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003713" MajorTopicYN="N">Dendritic Cells</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004705" MajorTopicYN="N">Endocytosis</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015395" MajorTopicYN="N">Histocompatibility Antigens Class I</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000949" MajorTopicYN="N">Histocompatibility Antigens Class II</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D037181" MajorTopicYN="N">Lectins, C-Type</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018345" MajorTopicYN="N">Mice, Knockout</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015778" MajorTopicYN="N">Minor Histocompatibility Antigens</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011956" MajorTopicYN="N">Receptors, Cell Surface</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011971" MajorTopicYN="N">Receptors, Immunologic</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014611" MajorTopicYN="N">Vaccination</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014612" MajorTopicYN="N">Vaccines</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year>
<Month>2</Month>
<Day>6</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2015</Year>
<Month>2</Month>
<Day>6</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="medline"><Year>2015</Year>
<Month>6</Month>
<Day>20</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">25653426</ArticleId>
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<ArticleId IdType="doi">10.4049/jimmunol.1402535</ArticleId>
</ArticleIdList>
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</pubmed>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>France</li>
</country>
<region><li>Victoria (État)</li>
</region>
<settlement><li>Melbourne</li>
</settlement>
<orgName><li>Université de Melbourne</li>
</orgName>
</list>
<tree><country name="Allemagne"><noRegion><name sortKey="Reuter, Anika" sort="Reuter, Anika" uniqKey="Reuter A" first="Anika" last="Reuter">Anika Reuter</name>
</noRegion>
</country>
<country name="Australie"><region name="Victoria (État)"><name sortKey="Panozza, Scott E" sort="Panozza, Scott E" uniqKey="Panozza S" first="Scott E" last="Panozza">Scott E. Panozza</name>
</region>
<name sortKey="Caminschi, Irina" sort="Caminschi, Irina" uniqKey="Caminschi I" first="Irina" last="Caminschi">Irina Caminschi</name>
<name sortKey="Dumont, Claire" sort="Dumont, Claire" uniqKey="Dumont C" first="Claire" last="Dumont">Claire Dumont</name>
<name sortKey="Gupta, Nishma" sort="Gupta, Nishma" uniqKey="Gupta N" first="Nishma" last="Gupta">Nishma Gupta</name>
<name sortKey="Johnston, Angus P R" sort="Johnston, Angus P R" uniqKey="Johnston A" first="Angus P R" last="Johnston">Angus P R. Johnston</name>
<name sortKey="Li, Jessica" sort="Li, Jessica" uniqKey="Li J" first="Jessica" last="Li">Jessica Li</name>
<name sortKey="Liu, Haiyin" sort="Liu, Haiyin" uniqKey="Liu H" first="Haiyin" last="Liu">Haiyin Liu</name>
<name sortKey="Macri, Christophe" sort="Macri, Christophe" uniqKey="Macri C" first="Christophe" last="Macri">Christophe Macri</name>
<name sortKey="Mintern, Justine D" sort="Mintern, Justine D" uniqKey="Mintern J" first="Justine D" last="Mintern">Justine D. Mintern</name>
<name sortKey="Vega Ramos, Javier" sort="Vega Ramos, Javier" uniqKey="Vega Ramos J" first="Javier" last="Vega-Ramos">Javier Vega-Ramos</name>
<name sortKey="Villadangos, Jose A" sort="Villadangos, Jose A" uniqKey="Villadangos J" first="Jose A" last="Villadangos">Jose A. Villadangos</name>
</country>
<country name="France"><noRegion><name sortKey="Segura, Elodie" sort="Segura, Elodie" uniqKey="Segura E" first="Elodie" last="Segura">Elodie Segura</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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Criteria for dendritic cell receptor selection for efficient antibody-targeted vaccination.

Criteria for dendritic cell receptor selection for efficient antibody-targeted vaccination.

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