Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential.
Identifieur interne : 002B39 ( PubMed/Checkpoint ); précédent : 002B38; suivant : 002B40Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential.
Auteurs : Daniel L. Worthley [Australie] ; Michael Churchill [États-Unis] ; Jocelyn T. Compton [États-Unis] ; Yagnesh Tailor [États-Unis] ; Meenakshi Rao [États-Unis] ; Yiling Si [États-Unis] ; Daniel Levin [États-Unis] ; Matthew G. Schwartz [États-Unis] ; Aysu Uygur [États-Unis] ; Yoku Hayakawa [États-Unis] ; Stefanie Gross [États-Unis] ; Bernhard W. Renz [États-Unis] ; Wanda Setlik [États-Unis] ; Ashley N. Martinez [États-Unis] ; Xiaowei Chen [États-Unis] ; Saqib Nizami [États-Unis] ; Heon Goo Lee [États-Unis] ; H Paco Kang [États-Unis] ; Jon-Michael Caldwell [États-Unis] ; Samuel Asfaha [États-Unis] ; C Benedikt Westphalen [Allemagne] ; Trevor Graham [Royaume-Uni] ; Guangchun Jin [États-Unis] ; Karan Nagar [États-Unis] ; Hongshan Wang [États-Unis] ; Mazen A. Kheirbek [États-Unis] ; Alka Kolhe [États-Unis] ; Jared Carpenter [États-Unis] ; Mark Glaire [États-Unis] ; Abhinav Nair [États-Unis] ; Simon Renders [États-Unis] ; Nicholas Manieri [États-Unis] ; Sureshkumar Muthupalani [États-Unis] ; James G. Fox [États-Unis] ; Maximilian Reichert [États-Unis] ; Andrew S. Giraud [Australie] ; Robert F. Schwabe [États-Unis] ; Jean-Phillipe Pradere [France] ; Katherine Walton [États-Unis] ; Ajay Prakash [États-Unis] ; Deborah Gumucio [États-Unis] ; Anil K. Rustgi [États-Unis] ; Thaddeus S. Stappenbeck [États-Unis] ; Richard A. Friedman [États-Unis] ; Michael D. Gershon [États-Unis] ; Peter Sims [États-Unis] ; Tracy Grikscheit [États-Unis] ; Francis Y. Lee [États-Unis] ; Gerard Karsenty [États-Unis] ; Siddhartha Mukherjee [États-Unis] ; Timothy C. Wang [États-Unis]Source :
- Cell [ 1097-4172 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Cartilage (métabolisme), Cellules stromales mésenchymateuses (cytologie), Cellules stromales mésenchymateuses (métabolisme), Intestin grêle (cytologie), Intestin grêle (métabolisme), Os et tissu osseux (cytologie), Protéines et peptides de signalisation intercellulaire (métabolisme), Souris, Souris de lignée C57BL.
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Intercellular Signaling Peptides and Proteins.
- cytology : Bone and Bones, Intestine, Small, Mesenchymal Stromal Cells.
- metabolism : Cartilage, Intestine, Small, Mesenchymal Stromal Cells.
- Animals, Mice, Mice, Inbred C57BL.
Abstract
The stem cells that maintain and repair the postnatal skeleton remain undefined. One model suggests that perisinusoidal mesenchymal stem cells (MSCs) give rise to osteoblasts, chondrocytes, marrow stromal cells, and adipocytes, although the existence of these cells has not been proven through fate-mapping experiments. We demonstrate here that expression of the bone morphogenetic protein (BMP) antagonist gremlin 1 defines a population of osteochondroreticular (OCR) stem cells in the bone marrow. OCR stem cells self-renew and generate osteoblasts, chondrocytes, and reticular marrow stromal cells, but not adipocytes. OCR stem cells are concentrated within the metaphysis of long bones not in the perisinusoidal space and are needed for bone development, bone remodeling, and fracture repair. Grem1 expression also identifies intestinal reticular stem cells (iRSCs) that are cells of origin for the periepithelial intestinal mesenchymal sheath. Grem1 expression identifies distinct connective tissue stem cells in both the bone (OCR stem cells) and the intestine (iRSCs).
DOI: 10.1016/j.cell.2014.11.042
PubMed: 25594183
Affiliations:
- Allemagne, Australie, France, Royaume-Uni, États-Unis
- Angleterre, Bavière, Californie, District de Haute-Bavière, Grand Londres, Massachusetts, Michigan, Midi-Pyrénées, Missouri (État), Occitanie (région administrative), Pennsylvanie, État de New York
- Londres, Los Angeles, Munich, New York, Toulouse
- Université Columbia, Université de Californie du Sud, Université de Londres
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:25594183Le document en format XML
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Renz</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Setlik, Wanda" sort="Setlik, Wanda" uniqKey="Setlik W" first="Wanda" last="Setlik">Wanda Setlik</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Cell Biology, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Martinez, Ashley N" sort="Martinez, Ashley N" uniqKey="Martinez A" first="Ashley N" last="Martinez">Ashley N. Martinez</name><affiliation wicri:level="2"><nlm:affiliation>Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Chen, Xiaowei" sort="Chen, Xiaowei" uniqKey="Chen X" first="Xiaowei" last="Chen">Xiaowei Chen</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Nizami, Saqib" sort="Nizami, Saqib" uniqKey="Nizami S" first="Saqib" last="Nizami">Saqib Nizami</name><affiliation wicri:level="2"><nlm:affiliation>Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Lee, Heon Goo" sort="Lee, Heon Goo" uniqKey="Lee H" first="Heon Goo" last="Lee">Heon Goo Lee</name><affiliation wicri:level="2"><nlm:affiliation>Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Kang, H Paco" sort="Kang, H Paco" uniqKey="Kang H" first="H Paco" last="Kang">H Paco Kang</name><affiliation wicri:level="2"><nlm:affiliation>Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Caldwell, Jon Michael" sort="Caldwell, Jon Michael" uniqKey="Caldwell J" first="Jon-Michael" last="Caldwell">Jon-Michael Caldwell</name><affiliation wicri:level="2"><nlm:affiliation>Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Asfaha, Samuel" sort="Asfaha, Samuel" uniqKey="Asfaha S" first="Samuel" last="Asfaha">Samuel Asfaha</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Westphalen, C Benedikt" sort="Westphalen, C Benedikt" uniqKey="Westphalen C" first="C Benedikt" last="Westphalen">C Benedikt Westphalen</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA; Department of Internal Medicine III, University Hospital Munich, Ludwig-Maximilians-University Munich - Campus Groβhadern, Munich 81377, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA; Department of Internal Medicine III, University Hospital Munich, Ludwig-Maximilians-University Munich - Campus Groβhadern, Munich 81377</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Graham, Trevor" sort="Graham, Trevor" uniqKey="Graham T" first="Trevor" last="Graham">Trevor Graham</name><affiliation wicri:level="4"><nlm:affiliation>Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ</wicri:regionArea><orgName type="university">Université de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Jin, Guangchun" sort="Jin, Guangchun" uniqKey="Jin G" first="Guangchun" last="Jin">Guangchun Jin</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Nagar, Karan" sort="Nagar, Karan" uniqKey="Nagar K" first="Karan" last="Nagar">Karan Nagar</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Wang, Hongshan" sort="Wang, Hongshan" uniqKey="Wang H" first="Hongshan" last="Wang">Hongshan Wang</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Kheirbek, Mazen A" sort="Kheirbek, Mazen A" uniqKey="Kheirbek M" first="Mazen A" last="Kheirbek">Mazen A. Kheirbek</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Kolhe, Alka" sort="Kolhe, Alka" uniqKey="Kolhe A" first="Alka" last="Kolhe">Alka Kolhe</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Carpenter, Jared" sort="Carpenter, Jared" uniqKey="Carpenter J" first="Jared" last="Carpenter">Jared Carpenter</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Glaire, Mark" sort="Glaire, Mark" uniqKey="Glaire M" first="Mark" last="Glaire">Mark Glaire</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Nair, Abhinav" sort="Nair, Abhinav" uniqKey="Nair A" first="Abhinav" last="Nair">Abhinav Nair</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Renders, Simon" sort="Renders, Simon" uniqKey="Renders S" first="Simon" last="Renders">Simon Renders</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Manieri, Nicholas" sort="Manieri, Nicholas" uniqKey="Manieri N" first="Nicholas" last="Manieri">Nicholas Manieri</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Immunology, Washington University, St. Louis, MO 63110, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Immunology, Washington University, St. Louis, MO 63110</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Muthupalani, Sureshkumar" sort="Muthupalani, Sureshkumar" uniqKey="Muthupalani S" first="Sureshkumar" last="Muthupalani">Sureshkumar Muthupalani</name><affiliation wicri:level="2"><nlm:affiliation>Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Fox, James G" sort="Fox, James G" uniqKey="Fox J" first="James G" last="Fox">James G. Fox</name><affiliation wicri:level="2"><nlm:affiliation>Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Reichert, Maximilian" sort="Reichert, Maximilian" uniqKey="Reichert M" first="Maximilian" last="Reichert">Maximilian Reichert</name><affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology, Departments of Medicine and Genetics, Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Gastroenterology, Departments of Medicine and Genetics, Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Giraud, Andrew S" sort="Giraud, Andrew S" uniqKey="Giraud A" first="Andrew S" last="Giraud">Andrew S. Giraud</name><affiliation wicri:level="1"><nlm:affiliation>Murdoch Children's Research Institute, Royal Children's Hospital, Vic., 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Murdoch Children's Research Institute, Royal Children's Hospital, Vic., 3052</wicri:regionArea><wicri:noRegion>3052</wicri:noRegion></affiliation></author><author><name sortKey="Schwabe, Robert F" sort="Schwabe, Robert F" uniqKey="Schwabe R" first="Robert F" last="Schwabe">Robert F. Schwabe</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Pradere, Jean Phillipe" sort="Pradere, Jean Phillipe" uniqKey="Pradere J" first="Jean-Phillipe" last="Pradere">Jean-Phillipe Pradere</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA; Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paul Sabatier, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC)- UMR1048, Toulouse 31432, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA; Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paul Sabatier, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC)- UMR1048, Toulouse 31432</wicri:regionArea><wicri:noRegion>31432</wicri:noRegion><placeName><settlement type="city">Toulouse</settlement><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Midi-Pyrénées</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Walton, Katherine" sort="Walton, Katherine" uniqKey="Walton K" first="Katherine" last="Walton">Katherine Walton</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Prakash, Ajay" sort="Prakash, Ajay" uniqKey="Prakash A" first="Ajay" last="Prakash">Ajay Prakash</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Gumucio, Deborah" sort="Gumucio, Deborah" uniqKey="Gumucio D" first="Deborah" last="Gumucio">Deborah Gumucio</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Rustgi, Anil K" sort="Rustgi, Anil K" uniqKey="Rustgi A" first="Anil K" last="Rustgi">Anil K. Rustgi</name><affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology, Departments of Medicine and Genetics, Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Gastroenterology, Departments of Medicine and Genetics, Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Stappenbeck, Thaddeus S" sort="Stappenbeck, Thaddeus S" uniqKey="Stappenbeck T" first="Thaddeus S" last="Stappenbeck">Thaddeus S. Stappenbeck</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Immunology, Washington University, St. Louis, MO 63110, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Immunology, Washington University, St. Louis, MO 63110</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Friedman, Richard A" sort="Friedman, Richard A" uniqKey="Friedman R" first="Richard A" last="Friedman">Richard A. Friedman</name><affiliation wicri:level="4"><nlm:affiliation>Herbert Irving Comprehensive Cancer Center Biomedical Informatics Shared Resource and Department of Biomedical Informatics, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Herbert Irving Comprehensive Cancer Center Biomedical Informatics Shared Resource and Department of Biomedical Informatics, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Gershon, Michael D" sort="Gershon, Michael D" uniqKey="Gershon M" first="Michael D" last="Gershon">Michael D. Gershon</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Cell Biology, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Sims, Peter" sort="Sims, Peter" uniqKey="Sims P" first="Peter" last="Sims">Peter Sims</name><affiliation wicri:level="4"><nlm:affiliation>Department of Systems Biology, Columbia University, NY, 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Systems Biology, Columbia University, NY, 10032</wicri:regionArea><orgName type="university">Université Columbia</orgName><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Grikscheit, Tracy" sort="Grikscheit, Tracy" uniqKey="Grikscheit T" first="Tracy" last="Grikscheit">Tracy Grikscheit</name><affiliation wicri:level="4"><nlm:affiliation>Children's Hospital Los Angeles, Saban Research Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90027, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Children's Hospital Los Angeles, Saban Research Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90027</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Lee, Francis Y" sort="Lee, Francis Y" uniqKey="Lee F" first="Francis Y" last="Lee">Francis Y. Lee</name><affiliation wicri:level="2"><nlm:affiliation>Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Karsenty, Gerard" sort="Karsenty, Gerard" uniqKey="Karsenty G" first="Gerard" last="Karsenty">Gerard Karsenty</name><affiliation wicri:level="4"><nlm:affiliation>Department of Genetics and Development, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics and Development, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Mukherjee, Siddhartha" sort="Mukherjee, Siddhartha" uniqKey="Mukherjee S" first="Siddhartha" last="Mukherjee">Siddhartha Mukherjee</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA. Electronic address: sm3252@columbia.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Wang, Timothy C" sort="Wang, Timothy C" uniqKey="Wang T" first="Timothy C" last="Wang">Timothy C. Wang</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA. Electronic address: tcw21@columbia.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25594183</idno><idno type="pmid">25594183</idno><idno type="doi">10.1016/j.cell.2014.11.042</idno><idno type="wicri:Area/PubMed/Corpus">003114</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003114</idno><idno type="wicri:Area/PubMed/Curation">003018</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003018</idno><idno type="wicri:Area/PubMed/Checkpoint">003018</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003018</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential.</title><author><name sortKey="Worthley, Daniel L" sort="Worthley, Daniel L" uniqKey="Worthley D" first="Daniel L" last="Worthley">Daniel L. Worthley</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA; Department of Medicine, University of Adelaide, SA, 5005, Australia; Cancer theme, South Australian Health and Medical Research Institute, SA, 5001, Australia; Murdoch Children's Research Institute, Royal Children's Hospital, Vic., 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA; Department of Medicine, University of Adelaide, SA, 5005, Australia; Cancer theme, South Australian Health and Medical Research Institute, SA, 5001, Australia; Murdoch Children's Research Institute, Royal Children's Hospital, Vic., 3052</wicri:regionArea><orgName type="university">Université Columbia</orgName><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Churchill, Michael" sort="Churchill, Michael" uniqKey="Churchill M" first="Michael" last="Churchill">Michael Churchill</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Compton, Jocelyn T" sort="Compton, Jocelyn T" uniqKey="Compton J" first="Jocelyn T" last="Compton">Jocelyn T. Compton</name><affiliation wicri:level="2"><nlm:affiliation>Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Tailor, Yagnesh" sort="Tailor, Yagnesh" uniqKey="Tailor Y" first="Yagnesh" last="Tailor">Yagnesh Tailor</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Rao, Meenakshi" sort="Rao, Meenakshi" uniqKey="Rao M" first="Meenakshi" last="Rao">Meenakshi Rao</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pediatrics, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Si, Yiling" sort="Si, Yiling" uniqKey="Si Y" first="Yiling" last="Si">Yiling Si</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Levin, Daniel" sort="Levin, Daniel" uniqKey="Levin D" first="Daniel" last="Levin">Daniel Levin</name><affiliation wicri:level="4"><nlm:affiliation>Children's Hospital Los Angeles, Saban Research Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90027, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Children's Hospital Los Angeles, Saban Research Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90027</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Schwartz, Matthew G" sort="Schwartz, Matthew G" uniqKey="Schwartz M" first="Matthew G" last="Schwartz">Matthew G. Schwartz</name><affiliation wicri:level="2"><nlm:affiliation>Department of Genetics, Harvard Medical School, Boston, MA 02114, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, Harvard Medical School, Boston, MA 02114</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Uygur, Aysu" sort="Uygur, Aysu" uniqKey="Uygur A" first="Aysu" last="Uygur">Aysu Uygur</name><affiliation wicri:level="2"><nlm:affiliation>Department of Genetics, Harvard Medical School, Boston, MA 02114, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, Harvard Medical School, Boston, MA 02114</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Hayakawa, Yoku" sort="Hayakawa, Yoku" uniqKey="Hayakawa Y" first="Yoku" last="Hayakawa">Yoku Hayakawa</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Gross, Stefanie" sort="Gross, Stefanie" uniqKey="Gross S" first="Stefanie" last="Gross">Stefanie Gross</name><affiliation wicri:level="4"><nlm:affiliation>Department of Genetics and Development, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics and Development, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Renz, Bernhard W" sort="Renz, Bernhard W" uniqKey="Renz B" first="Bernhard W" last="Renz">Bernhard W. Renz</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Setlik, Wanda" sort="Setlik, Wanda" uniqKey="Setlik W" first="Wanda" last="Setlik">Wanda Setlik</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Cell Biology, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Martinez, Ashley N" sort="Martinez, Ashley N" uniqKey="Martinez A" first="Ashley N" last="Martinez">Ashley N. Martinez</name><affiliation wicri:level="2"><nlm:affiliation>Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Chen, Xiaowei" sort="Chen, Xiaowei" uniqKey="Chen X" first="Xiaowei" last="Chen">Xiaowei Chen</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Nizami, Saqib" sort="Nizami, Saqib" uniqKey="Nizami S" first="Saqib" last="Nizami">Saqib Nizami</name><affiliation wicri:level="2"><nlm:affiliation>Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Lee, Heon Goo" sort="Lee, Heon Goo" uniqKey="Lee H" first="Heon Goo" last="Lee">Heon Goo Lee</name><affiliation wicri:level="2"><nlm:affiliation>Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Kang, H Paco" sort="Kang, H Paco" uniqKey="Kang H" first="H Paco" last="Kang">H Paco Kang</name><affiliation wicri:level="2"><nlm:affiliation>Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Caldwell, Jon Michael" sort="Caldwell, Jon Michael" uniqKey="Caldwell J" first="Jon-Michael" last="Caldwell">Jon-Michael Caldwell</name><affiliation wicri:level="2"><nlm:affiliation>Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Asfaha, Samuel" sort="Asfaha, Samuel" uniqKey="Asfaha S" first="Samuel" last="Asfaha">Samuel Asfaha</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Westphalen, C Benedikt" sort="Westphalen, C Benedikt" uniqKey="Westphalen C" first="C Benedikt" last="Westphalen">C Benedikt Westphalen</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA; Department of Internal Medicine III, University Hospital Munich, Ludwig-Maximilians-University Munich - Campus Groβhadern, Munich 81377, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA; Department of Internal Medicine III, University Hospital Munich, Ludwig-Maximilians-University Munich - Campus Groβhadern, Munich 81377</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Graham, Trevor" sort="Graham, Trevor" uniqKey="Graham T" first="Trevor" last="Graham">Trevor Graham</name><affiliation wicri:level="4"><nlm:affiliation>Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ</wicri:regionArea><orgName type="university">Université de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Jin, Guangchun" sort="Jin, Guangchun" uniqKey="Jin G" first="Guangchun" last="Jin">Guangchun Jin</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Nagar, Karan" sort="Nagar, Karan" uniqKey="Nagar K" first="Karan" last="Nagar">Karan Nagar</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Wang, Hongshan" sort="Wang, Hongshan" uniqKey="Wang H" first="Hongshan" last="Wang">Hongshan Wang</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Kheirbek, Mazen A" sort="Kheirbek, Mazen A" uniqKey="Kheirbek M" first="Mazen A" last="Kheirbek">Mazen A. Kheirbek</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Kolhe, Alka" sort="Kolhe, Alka" uniqKey="Kolhe A" first="Alka" last="Kolhe">Alka Kolhe</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Carpenter, Jared" sort="Carpenter, Jared" uniqKey="Carpenter J" first="Jared" last="Carpenter">Jared Carpenter</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Glaire, Mark" sort="Glaire, Mark" uniqKey="Glaire M" first="Mark" last="Glaire">Mark Glaire</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Nair, Abhinav" sort="Nair, Abhinav" uniqKey="Nair A" first="Abhinav" last="Nair">Abhinav Nair</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Renders, Simon" sort="Renders, Simon" uniqKey="Renders S" first="Simon" last="Renders">Simon Renders</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Manieri, Nicholas" sort="Manieri, Nicholas" uniqKey="Manieri N" first="Nicholas" last="Manieri">Nicholas Manieri</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Immunology, Washington University, St. Louis, MO 63110, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Immunology, Washington University, St. Louis, MO 63110</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Muthupalani, Sureshkumar" sort="Muthupalani, Sureshkumar" uniqKey="Muthupalani S" first="Sureshkumar" last="Muthupalani">Sureshkumar Muthupalani</name><affiliation wicri:level="2"><nlm:affiliation>Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Fox, James G" sort="Fox, James G" uniqKey="Fox J" first="James G" last="Fox">James G. Fox</name><affiliation wicri:level="2"><nlm:affiliation>Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Reichert, Maximilian" sort="Reichert, Maximilian" uniqKey="Reichert M" first="Maximilian" last="Reichert">Maximilian Reichert</name><affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology, Departments of Medicine and Genetics, Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Gastroenterology, Departments of Medicine and Genetics, Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Giraud, Andrew S" sort="Giraud, Andrew S" uniqKey="Giraud A" first="Andrew S" last="Giraud">Andrew S. Giraud</name><affiliation wicri:level="1"><nlm:affiliation>Murdoch Children's Research Institute, Royal Children's Hospital, Vic., 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Murdoch Children's Research Institute, Royal Children's Hospital, Vic., 3052</wicri:regionArea><wicri:noRegion>3052</wicri:noRegion></affiliation></author><author><name sortKey="Schwabe, Robert F" sort="Schwabe, Robert F" uniqKey="Schwabe R" first="Robert F" last="Schwabe">Robert F. Schwabe</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Pradere, Jean Phillipe" sort="Pradere, Jean Phillipe" uniqKey="Pradere J" first="Jean-Phillipe" last="Pradere">Jean-Phillipe Pradere</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA; Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paul Sabatier, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC)- UMR1048, Toulouse 31432, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA; Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paul Sabatier, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC)- UMR1048, Toulouse 31432</wicri:regionArea><wicri:noRegion>31432</wicri:noRegion><placeName><settlement type="city">Toulouse</settlement><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Midi-Pyrénées</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Walton, Katherine" sort="Walton, Katherine" uniqKey="Walton K" first="Katherine" last="Walton">Katherine Walton</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Prakash, Ajay" sort="Prakash, Ajay" uniqKey="Prakash A" first="Ajay" last="Prakash">Ajay Prakash</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Gumucio, Deborah" sort="Gumucio, Deborah" uniqKey="Gumucio D" first="Deborah" last="Gumucio">Deborah Gumucio</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Rustgi, Anil K" sort="Rustgi, Anil K" uniqKey="Rustgi A" first="Anil K" last="Rustgi">Anil K. Rustgi</name><affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology, Departments of Medicine and Genetics, Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Gastroenterology, Departments of Medicine and Genetics, Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Stappenbeck, Thaddeus S" sort="Stappenbeck, Thaddeus S" uniqKey="Stappenbeck T" first="Thaddeus S" last="Stappenbeck">Thaddeus S. Stappenbeck</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Immunology, Washington University, St. Louis, MO 63110, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Immunology, Washington University, St. Louis, MO 63110</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Friedman, Richard A" sort="Friedman, Richard A" uniqKey="Friedman R" first="Richard A" last="Friedman">Richard A. Friedman</name><affiliation wicri:level="4"><nlm:affiliation>Herbert Irving Comprehensive Cancer Center Biomedical Informatics Shared Resource and Department of Biomedical Informatics, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Herbert Irving Comprehensive Cancer Center Biomedical Informatics Shared Resource and Department of Biomedical Informatics, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Gershon, Michael D" sort="Gershon, Michael D" uniqKey="Gershon M" first="Michael D" last="Gershon">Michael D. Gershon</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Cell Biology, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Sims, Peter" sort="Sims, Peter" uniqKey="Sims P" first="Peter" last="Sims">Peter Sims</name><affiliation wicri:level="4"><nlm:affiliation>Department of Systems Biology, Columbia University, NY, 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Systems Biology, Columbia University, NY, 10032</wicri:regionArea><orgName type="university">Université Columbia</orgName><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Grikscheit, Tracy" sort="Grikscheit, Tracy" uniqKey="Grikscheit T" first="Tracy" last="Grikscheit">Tracy Grikscheit</name><affiliation wicri:level="4"><nlm:affiliation>Children's Hospital Los Angeles, Saban Research Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90027, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Children's Hospital Los Angeles, Saban Research Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90027</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Lee, Francis Y" sort="Lee, Francis Y" uniqKey="Lee F" first="Francis Y" last="Lee">Francis Y. Lee</name><affiliation wicri:level="2"><nlm:affiliation>Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Karsenty, Gerard" sort="Karsenty, Gerard" uniqKey="Karsenty G" first="Gerard" last="Karsenty">Gerard Karsenty</name><affiliation wicri:level="4"><nlm:affiliation>Department of Genetics and Development, Columbia University, New York, NY 10032, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics and Development, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Mukherjee, Siddhartha" sort="Mukherjee, Siddhartha" uniqKey="Mukherjee S" first="Siddhartha" last="Mukherjee">Siddhartha Mukherjee</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA. Electronic address: sm3252@columbia.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Wang, Timothy C" sort="Wang, Timothy C" uniqKey="Wang T" first="Timothy C" last="Wang">Timothy C. Wang</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA. Electronic address: tcw21@columbia.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author></analytic><series><title level="j">Cell</title><idno type="eISSN">1097-4172</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Bone and Bones (cytology)</term><term>Cartilage (metabolism)</term><term>Intercellular Signaling Peptides and Proteins (metabolism)</term><term>Intestine, Small (cytology)</term><term>Intestine, Small (metabolism)</term><term>Mesenchymal Stromal Cells (cytology)</term><term>Mesenchymal Stromal Cells (metabolism)</term><term>Mice</term><term>Mice, Inbred C57BL</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cartilage (métabolisme)</term><term>Cellules stromales mésenchymateuses (cytologie)</term><term>Cellules stromales mésenchymateuses (métabolisme)</term><term>Intestin grêle (cytologie)</term><term>Intestin grêle (métabolisme)</term><term>Os et tissu osseux (cytologie)</term><term>Protéines et peptides de signalisation intercellulaire (métabolisme)</term><term>Souris</term><term>Souris de lignée C57BL</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Intercellular Signaling Peptides and Proteins</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules stromales mésenchymateuses</term><term>Intestin grêle</term><term>Os et tissu osseux</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Bone and Bones</term><term>Intestine, Small</term><term>Mesenchymal Stromal Cells</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cartilage</term><term>Intestine, Small</term><term>Mesenchymal Stromal Cells</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cartilage</term><term>Cellules stromales mésenchymateuses</term><term>Intestin grêle</term><term>Protéines et peptides de signalisation intercellulaire</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Mice</term><term>Mice, Inbred C57BL</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Souris</term><term>Souris de lignée C57BL</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The stem cells that maintain and repair the postnatal skeleton remain undefined. One model suggests that perisinusoidal mesenchymal stem cells (MSCs) give rise to osteoblasts, chondrocytes, marrow stromal cells, and adipocytes, although the existence of these cells has not been proven through fate-mapping experiments. We demonstrate here that expression of the bone morphogenetic protein (BMP) antagonist gremlin 1 defines a population of osteochondroreticular (OCR) stem cells in the bone marrow. OCR stem cells self-renew and generate osteoblasts, chondrocytes, and reticular marrow stromal cells, but not adipocytes. OCR stem cells are concentrated within the metaphysis of long bones not in the perisinusoidal space and are needed for bone development, bone remodeling, and fracture repair. Grem1 expression also identifies intestinal reticular stem cells (iRSCs) that are cells of origin for the periepithelial intestinal mesenchymal sheath. Grem1 expression identifies distinct connective tissue stem cells in both the bone (OCR stem cells) and the intestine (iRSCs).</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25594183</PMID><DateCreated><Year>2015</Year><Month>01</Month><Day>17</Day></DateCreated><DateCompleted><Year>2015</Year><Month>04</Month><Day>07</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1097-4172</ISSN><JournalIssue CitedMedium="Internet"><Volume>160</Volume><Issue>1-2</Issue><PubDate><Year>2015</Year><Month>Jan</Month><Day>15</Day></PubDate></JournalIssue><Title>Cell</Title><ISOAbbreviation>Cell</ISOAbbreviation></Journal><ArticleTitle>Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential.</ArticleTitle><Pagination><MedlinePgn>269-84</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.cell.2014.11.042</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0092-8674(14)01519-0</ELocationID><Abstract><AbstractText>The stem cells that maintain and repair the postnatal skeleton remain undefined. One model suggests that perisinusoidal mesenchymal stem cells (MSCs) give rise to osteoblasts, chondrocytes, marrow stromal cells, and adipocytes, although the existence of these cells has not been proven through fate-mapping experiments. We demonstrate here that expression of the bone morphogenetic protein (BMP) antagonist gremlin 1 defines a population of osteochondroreticular (OCR) stem cells in the bone marrow. OCR stem cells self-renew and generate osteoblasts, chondrocytes, and reticular marrow stromal cells, but not adipocytes. OCR stem cells are concentrated within the metaphysis of long bones not in the perisinusoidal space and are needed for bone development, bone remodeling, and fracture repair. Grem1 expression also identifies intestinal reticular stem cells (iRSCs) that are cells of origin for the periepithelial intestinal mesenchymal sheath. Grem1 expression identifies distinct connective tissue stem cells in both the bone (OCR stem cells) and the intestine (iRSCs).</AbstractText><CopyrightInformation>Copyright © 2015 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Worthley</LastName><ForeName>Daniel L</ForeName><Initials>DL</Initials><AffiliationInfo><Affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA; Department of Medicine, University of Adelaide, SA, 5005, Australia; Cancer theme, South Australian Health and Medical Research Institute, SA, 5001, Australia; Murdoch Children's Research Institute, Royal Children's Hospital, Vic., 3052, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Churchill</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Compton</LastName><ForeName>Jocelyn T</ForeName><Initials>JT</Initials><AffiliationInfo><Affiliation>Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tailor</LastName><ForeName>Yagnesh</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rao</LastName><ForeName>Meenakshi</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Columbia University, New York, NY 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Si</LastName><ForeName>Yiling</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Levin</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Children's Hospital Los Angeles, Saban Research Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90027, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schwartz</LastName><ForeName>Matthew G</ForeName><Initials>MG</Initials><AffiliationInfo><Affiliation>Department of Genetics, Harvard Medical School, Boston, MA 02114, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Uygur</LastName><ForeName>Aysu</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Genetics, Harvard Medical School, Boston, MA 02114, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hayakawa</LastName><ForeName>Yoku</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gross</LastName><ForeName>Stefanie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Genetics and Development, Columbia University, New York, NY 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Renz</LastName><ForeName>Bernhard W</ForeName><Initials>BW</Initials><AffiliationInfo><Affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Setlik</LastName><ForeName>Wanda</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martinez</LastName><ForeName>Ashley N</ForeName><Initials>AN</Initials><AffiliationInfo><Affiliation>Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Xiaowei</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nizami</LastName><ForeName>Saqib</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Heon Goo</ForeName><Initials>HG</Initials><AffiliationInfo><Affiliation>Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kang</LastName><ForeName>H Paco</ForeName><Initials>HP</Initials><AffiliationInfo><Affiliation>Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Caldwell</LastName><ForeName>Jon-Michael</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Asfaha</LastName><ForeName>Samuel</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Westphalen</LastName><ForeName>C Benedikt</ForeName><Initials>CB</Initials><AffiliationInfo><Affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA; Department of Internal Medicine III, University Hospital Munich, Ludwig-Maximilians-University Munich - Campus Groβhadern, Munich 81377, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Graham</LastName><ForeName>Trevor</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jin</LastName><ForeName>Guangchun</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nagar</LastName><ForeName>Karan</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Hongshan</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kheirbek</LastName><ForeName>Mazen A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Columbia University, New York, NY 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kolhe</LastName><ForeName>Alka</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carpenter</LastName><ForeName>Jared</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Glaire</LastName><ForeName>Mark</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nair</LastName><ForeName>Abhinav</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Renders</LastName><ForeName>Simon</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Manieri</LastName><ForeName>Nicholas</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Pathology and Immunology, Washington University, St. Louis, MO 63110, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Muthupalani</LastName><ForeName>Sureshkumar</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fox</LastName><ForeName>James G</ForeName><Initials>JG</Initials><AffiliationInfo><Affiliation>Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reichert</LastName><ForeName>Maximilian</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Gastroenterology, Departments of Medicine and Genetics, Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giraud</LastName><ForeName>Andrew S</ForeName><Initials>AS</Initials><AffiliationInfo><Affiliation>Murdoch Children's Research Institute, Royal Children's Hospital, Vic., 3052, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schwabe</LastName><ForeName>Robert F</ForeName><Initials>RF</Initials><AffiliationInfo><Affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pradere</LastName><ForeName>Jean-Phillipe</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA; Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paul Sabatier, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC)- UMR1048, Toulouse 31432, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Walton</LastName><ForeName>Katherine</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Prakash</LastName><ForeName>Ajay</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gumucio</LastName><ForeName>Deborah</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rustgi</LastName><ForeName>Anil K</ForeName><Initials>AK</Initials><AffiliationInfo><Affiliation>Division of Gastroenterology, Departments of Medicine and Genetics, Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stappenbeck</LastName><ForeName>Thaddeus S</ForeName><Initials>TS</Initials><AffiliationInfo><Affiliation>Department of Pathology and Immunology, Washington University, St. Louis, MO 63110, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Friedman</LastName><ForeName>Richard A</ForeName><Initials>RA</Initials><AffiliationInfo><Affiliation>Herbert Irving Comprehensive Cancer Center Biomedical Informatics Shared Resource and Department of Biomedical Informatics, Columbia University, New York, NY 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gershon</LastName><ForeName>Michael D</ForeName><Initials>MD</Initials><AffiliationInfo><Affiliation>Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sims</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Systems Biology, Columbia University, NY, 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grikscheit</LastName><ForeName>Tracy</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Children's Hospital Los Angeles, Saban Research Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90027, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Francis Y</ForeName><Initials>FY</Initials><AffiliationInfo><Affiliation>Department of Orthopedic Surgery, Columbia University Medical Center, New York, NY 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Karsenty</LastName><ForeName>Gerard</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Genetics and Development, Columbia University, New York, NY 10032, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mukherjee</LastName><ForeName>Siddhartha</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA. Electronic address: sm3252@columbia.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Timothy C</ForeName><Initials>TC</Initials><AffiliationInfo><Affiliation>Department of Medicine and Irving Cancer Research Center, Columbia University, New York, NY 10032, USA. Electronic address: tcw21@columbia.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>5U54 CA126513</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 EB006834</GrantID><Acronym>EB</Acronym><Agency>NIBIB NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 NS015547</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>AR056246</GrantID><Acronym>AR</Acronym><Agency>NIAMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U54 CA126513</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 RHL115145A</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AR056246</GrantID><Acronym>AR</Acronym><Agency>NIAMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 ES002109</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>EB006834</GrantID><Acronym>EB</Acronym><Agency>NIBIB NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HL115145</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>T32 GM007315</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Cell</MedlineTA><NlmUniqueID>0413066</NlmUniqueID><ISSNLinking>0092-8674</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C522154">Grem1 protein, mouse</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D036341">Intercellular Signaling Peptides and Proteins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Nature. 2010 Aug 12;466(7308):829-34</RefSource><PMID Version="1">20703299</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Neurosci. 2010 Jan;13(1):133-40</RefSource><PMID Version="1">20023653</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 2010 Nov 4;116(18):3677-80</RefSource><PMID Version="1">20660291</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Annu Rev Physiol. 2011;73:213-37</RefSource><PMID Version="1">21054163</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cancer Cell. 2011 Feb 15;19(2):257-72</RefSource><PMID Version="1">21316604</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuron. 2011 Jun 9;70(5):908-23</RefSource><PMID Version="1">21658584</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Cell Physiol. 2012 Jan;227(1):269-77</RefSource><PMID Version="1">21412775</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Stem Cells. 2012 Feb;30(2):187-96</RefSource><PMID Version="1">22083974</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2012 Jan 26;481(7382):457-62</RefSource><PMID Version="1">22281595</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell Stem Cell. 2012 Mar 2;10(3):259-72</RefSource><PMID Version="1">22385654</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2012 Jun;44(6):699-703</RefSource><PMID Version="1">22561515</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurogastroenterol Motil. 2013 Jan;25(1):61-9.e7</RefSource><PMID Version="1">22998406</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Med. 2013 Jan;19(1):35-42</RefSource><PMID Version="1">23296015</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Methods Mol Biol. 2013;1001:299-309</RefSource><PMID Version="1">23494439</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Bone Miner Res. 2002 Jan;17(1):15-25</RefSource><PMID Version="1">11771662</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2003 May 15;423(6937):332-6</RefSource><PMID Version="1">12748651</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2003 Jul;34(3):303-7</RefSource><PMID Version="1">12808456</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Comp Neurol. 2004 Feb 9;469(3):311-24</RefSource><PMID Version="1">14730584</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Development. 2004 Jul;131(14):3401-10</RefSource><PMID Version="1">15201225</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hepatology. 2004 Nov;40(5):1151-9</RefSource><PMID Version="1">15389867</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell. 1997 May 30;89(5):747-54</RefSource><PMID Version="1">9182762</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Cell. 1998 Apr;1(5):673-83</RefSource><PMID Version="1">9660951</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Protoc. 2009;4(2):206-23</RefSource><PMID Version="1">19180090</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell Stem Cell. 2008 Sep 11;3(3):301-13</RefSource><PMID Version="1">18786417</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Med. 1999 Jun;5(6):623-8</RefSource><PMID Version="1">10371499</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Science. 2009 Feb 20;323(5917):1050-3</RefSource><PMID Version="1">19229034</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Stem Cells. 2009 May;27(5):1142-51</RefSource><PMID Version="1">19418444</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Exp Med. 2009 Oct 26;206(11):2483-96</RefSource><PMID Version="1">19841085</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Dev Cell. 2014 May 12;29(3):330-9</RefSource><PMID Version="1">24823376</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Dev Cell. 2014 May 12;29(3):340-9</RefSource><PMID Version="1">24823377</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cytotherapy. 2006;8(4):315-7</RefSource><PMID Version="1">16923606</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14842-7</RefSource><PMID Version="1">17003113</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell. 2007 Jun 29;129(7):1377-88</RefSource><PMID Version="1">17604725</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genesis. 2007 Sep;45(9):593-605</RefSource><PMID Version="1">17868096</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15418-23</RefSource><PMID Version="1">17881565</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell. 2007 Oct 19;131(2):324-36</RefSource><PMID Version="1">17956733</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2007 Oct 25;449(7165):1003-7</RefSource><PMID Version="1">17934449</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2008 Apr 1;180(7):4742-53</RefSource><PMID Version="1">18354198</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 2008 Jul 15;112(2):295-307</RefSource><PMID Version="1">18332228</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell Stem Cell. 2014 Aug 7;15(2):154-68</RefSource><PMID Version="1">24953181</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell. 2010 Oct 1;143(1):134-44</RefSource><PMID Version="1">20887898</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>Nat Rev Rheumatol. 2015 Apr;11(4):200-1</RefSource><PMID Version="1">25734973</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001842" MajorTopicYN="N">Bone and Bones</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="Y">cytology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002356" MajorTopicYN="N">Cartilage</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D036341" MajorTopicYN="N">Intercellular Signaling Peptides and Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007421" MajorTopicYN="N">Intestine, Small</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="Y">cytology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D059630" MajorTopicYN="N">Mesenchymal Stromal Cells</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="Y">cytology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">NIHMS645538</OtherID><OtherID Source="NLM">PMC4436082</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>05</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>09</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>11</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>1</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>1</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>4</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25594183</ArticleId><ArticleId IdType="pii">S0092-8674(14)01519-0</ArticleId><ArticleId IdType="doi">10.1016/j.cell.2014.11.042</ArticleId><ArticleId IdType="pmc">PMC4436082</ArticleId><ArticleId IdType="mid">NIHMS645538</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Bavière</li><li>Californie</li><li>District de Haute-Bavière</li><li>Grand Londres</li><li>Massachusetts</li><li>Michigan</li><li>Midi-Pyrénées</li><li>Missouri (État)</li><li>Occitanie (région administrative)</li><li>Pennsylvanie</li><li>État de New York</li></region><settlement><li>Londres</li><li>Los Angeles</li><li>Munich</li><li>New York</li><li>Toulouse</li></settlement><orgName><li>Université Columbia</li><li>Université de Californie du Sud</li><li>Université de Londres</li></orgName></list><tree><country name="Australie"><region name="État de New York"><name sortKey="Worthley, Daniel L" sort="Worthley, Daniel L" uniqKey="Worthley D" first="Daniel L" last="Worthley">Daniel L. Worthley</name></region><name sortKey="Giraud, Andrew S" sort="Giraud, Andrew S" uniqKey="Giraud A" first="Andrew S" last="Giraud">Andrew S. Giraud</name></country><country name="États-Unis"><region name="État de New York"><name sortKey="Churchill, Michael" sort="Churchill, Michael" uniqKey="Churchill M" first="Michael" last="Churchill">Michael Churchill</name></region><name sortKey="Asfaha, Samuel" sort="Asfaha, Samuel" uniqKey="Asfaha S" first="Samuel" last="Asfaha">Samuel Asfaha</name><name sortKey="Caldwell, Jon Michael" sort="Caldwell, Jon Michael" uniqKey="Caldwell J" first="Jon-Michael" last="Caldwell">Jon-Michael Caldwell</name><name sortKey="Carpenter, Jared" sort="Carpenter, Jared" uniqKey="Carpenter J" first="Jared" last="Carpenter">Jared Carpenter</name><name sortKey="Chen, Xiaowei" sort="Chen, Xiaowei" uniqKey="Chen X" first="Xiaowei" last="Chen">Xiaowei Chen</name><name sortKey="Compton, Jocelyn T" sort="Compton, Jocelyn T" uniqKey="Compton J" first="Jocelyn T" last="Compton">Jocelyn T. Compton</name><name sortKey="Fox, James G" sort="Fox, James G" uniqKey="Fox J" first="James G" last="Fox">James G. Fox</name><name sortKey="Friedman, Richard A" sort="Friedman, Richard A" uniqKey="Friedman R" first="Richard A" last="Friedman">Richard A. Friedman</name><name sortKey="Gershon, Michael D" sort="Gershon, Michael D" uniqKey="Gershon M" first="Michael D" last="Gershon">Michael D. Gershon</name><name sortKey="Glaire, Mark" sort="Glaire, Mark" uniqKey="Glaire M" first="Mark" last="Glaire">Mark Glaire</name><name sortKey="Grikscheit, Tracy" sort="Grikscheit, Tracy" uniqKey="Grikscheit T" first="Tracy" last="Grikscheit">Tracy Grikscheit</name><name sortKey="Gross, Stefanie" sort="Gross, Stefanie" uniqKey="Gross S" first="Stefanie" last="Gross">Stefanie Gross</name><name sortKey="Gumucio, Deborah" sort="Gumucio, Deborah" uniqKey="Gumucio D" first="Deborah" last="Gumucio">Deborah Gumucio</name><name sortKey="Hayakawa, Yoku" sort="Hayakawa, Yoku" uniqKey="Hayakawa Y" first="Yoku" last="Hayakawa">Yoku Hayakawa</name><name sortKey="Jin, Guangchun" sort="Jin, Guangchun" uniqKey="Jin G" first="Guangchun" last="Jin">Guangchun Jin</name><name sortKey="Kang, H Paco" sort="Kang, H Paco" uniqKey="Kang H" first="H Paco" last="Kang">H Paco Kang</name><name sortKey="Karsenty, Gerard" sort="Karsenty, Gerard" uniqKey="Karsenty G" first="Gerard" last="Karsenty">Gerard Karsenty</name><name sortKey="Kheirbek, Mazen A" sort="Kheirbek, Mazen A" uniqKey="Kheirbek M" first="Mazen A" last="Kheirbek">Mazen A. Kheirbek</name><name sortKey="Kolhe, Alka" sort="Kolhe, Alka" uniqKey="Kolhe A" first="Alka" last="Kolhe">Alka Kolhe</name><name sortKey="Lee, Francis Y" sort="Lee, Francis Y" uniqKey="Lee F" first="Francis Y" last="Lee">Francis Y. Lee</name><name sortKey="Lee, Heon Goo" sort="Lee, Heon Goo" uniqKey="Lee H" first="Heon Goo" last="Lee">Heon Goo Lee</name><name sortKey="Levin, Daniel" sort="Levin, Daniel" uniqKey="Levin D" first="Daniel" last="Levin">Daniel Levin</name><name sortKey="Manieri, Nicholas" sort="Manieri, Nicholas" uniqKey="Manieri N" first="Nicholas" last="Manieri">Nicholas Manieri</name><name sortKey="Martinez, Ashley N" sort="Martinez, Ashley N" uniqKey="Martinez A" first="Ashley N" last="Martinez">Ashley N. Martinez</name><name sortKey="Mukherjee, Siddhartha" sort="Mukherjee, Siddhartha" uniqKey="Mukherjee S" first="Siddhartha" last="Mukherjee">Siddhartha Mukherjee</name><name sortKey="Muthupalani, Sureshkumar" sort="Muthupalani, Sureshkumar" uniqKey="Muthupalani S" first="Sureshkumar" last="Muthupalani">Sureshkumar Muthupalani</name><name sortKey="Nagar, Karan" sort="Nagar, Karan" uniqKey="Nagar K" first="Karan" last="Nagar">Karan Nagar</name><name sortKey="Nair, Abhinav" sort="Nair, Abhinav" uniqKey="Nair A" first="Abhinav" last="Nair">Abhinav Nair</name><name sortKey="Nizami, Saqib" sort="Nizami, Saqib" uniqKey="Nizami S" first="Saqib" last="Nizami">Saqib Nizami</name><name sortKey="Prakash, Ajay" sort="Prakash, Ajay" uniqKey="Prakash A" first="Ajay" last="Prakash">Ajay Prakash</name><name sortKey="Rao, Meenakshi" sort="Rao, Meenakshi" uniqKey="Rao M" first="Meenakshi" last="Rao">Meenakshi Rao</name><name sortKey="Reichert, Maximilian" sort="Reichert, Maximilian" uniqKey="Reichert M" first="Maximilian" last="Reichert">Maximilian Reichert</name><name sortKey="Renders, Simon" sort="Renders, Simon" uniqKey="Renders S" first="Simon" last="Renders">Simon Renders</name><name sortKey="Renz, Bernhard W" sort="Renz, Bernhard W" uniqKey="Renz B" first="Bernhard W" last="Renz">Bernhard W. Renz</name><name sortKey="Rustgi, Anil K" sort="Rustgi, Anil K" uniqKey="Rustgi A" first="Anil K" last="Rustgi">Anil K. Rustgi</name><name sortKey="Schwabe, Robert F" sort="Schwabe, Robert F" uniqKey="Schwabe R" first="Robert F" last="Schwabe">Robert F. Schwabe</name><name sortKey="Schwartz, Matthew G" sort="Schwartz, Matthew G" uniqKey="Schwartz M" first="Matthew G" last="Schwartz">Matthew G. Schwartz</name><name sortKey="Setlik, Wanda" sort="Setlik, Wanda" uniqKey="Setlik W" first="Wanda" last="Setlik">Wanda Setlik</name><name sortKey="Si, Yiling" sort="Si, Yiling" uniqKey="Si Y" first="Yiling" last="Si">Yiling Si</name><name sortKey="Sims, Peter" sort="Sims, Peter" uniqKey="Sims P" first="Peter" last="Sims">Peter Sims</name><name sortKey="Stappenbeck, Thaddeus S" sort="Stappenbeck, Thaddeus S" uniqKey="Stappenbeck T" first="Thaddeus S" last="Stappenbeck">Thaddeus S. Stappenbeck</name><name sortKey="Tailor, Yagnesh" sort="Tailor, Yagnesh" uniqKey="Tailor Y" first="Yagnesh" last="Tailor">Yagnesh Tailor</name><name sortKey="Uygur, Aysu" sort="Uygur, Aysu" uniqKey="Uygur A" first="Aysu" last="Uygur">Aysu Uygur</name><name sortKey="Walton, Katherine" sort="Walton, Katherine" uniqKey="Walton K" first="Katherine" last="Walton">Katherine Walton</name><name sortKey="Wang, Hongshan" sort="Wang, Hongshan" uniqKey="Wang H" first="Hongshan" last="Wang">Hongshan Wang</name><name sortKey="Wang, Timothy C" sort="Wang, Timothy C" uniqKey="Wang T" first="Timothy C" last="Wang">Timothy C. Wang</name></country><country name="Allemagne"><region name="Bavière"><name sortKey="Westphalen, C Benedikt" sort="Westphalen, C Benedikt" uniqKey="Westphalen C" first="C Benedikt" last="Westphalen">C Benedikt Westphalen</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Graham, Trevor" sort="Graham, Trevor" uniqKey="Graham T" first="Trevor" last="Graham">Trevor Graham</name></region></country><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Pradere, Jean Phillipe" sort="Pradere, Jean Phillipe" uniqKey="Pradere J" first="Jean-Phillipe" last="Pradere">Jean-Phillipe Pradere</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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