Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1.
Identifieur interne : 002983 ( PubMed/Checkpoint ); précédent : 002982; suivant : 002984Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1.
Auteurs : Adrian Cortes [Australie] ; Sara L. Pulit [Pays-Bas] ; Paul J. Leo [Australie] ; Jenny J. Pointon [Royaume-Uni] ; Philip C. Robinson [Australie] ; Michael H. Weisman [États-Unis] ; Michael Ward [États-Unis] ; Lianne S. Gensler [États-Unis] ; Xiaodong Zhou [États-Unis] ; Henri-Jean Garchon [France] ; Gilles Chiocchia [France] ; Johannes Nossent [Australie] ; Benedicte A. Lie [Norvège] ; Ystein F Rre [Norvège] ; Jaakko Tuomilehto [Arabie saoudite] ; Kari Laiho [Finlande] ; Linda A. Bradbury [Australie] ; Dirk Elewaut [Belgique] ; Ruben Burgos-Vargas [Mexique] ; Simon Stebbings [Nouvelle-Zélande] ; Louise Appleton [Royaume-Uni] ; Claire Farrah [Royaume-Uni] ; Jonathan Lau [Royaume-Uni] ; Nigil Haroon [Canada] ; Juan Mulero [Espagne] ; Francisco J. Blanco [Espagne] ; Miguel A. Gonzalez-Gay [Espagne] ; C. Lopez-Larrea [Espagne] ; Paul Bowness [Royaume-Uni] ; Karl Gaffney [Royaume-Uni] ; Hill Gaston [Royaume-Uni] ; Dafna D. Gladman [Canada] ; Proton Rahman [Canada] ; Walter P. Maksymowych [Canada] ; J Bart A. Crusius [Pays-Bas] ; Irene E. Van Der Horst-Bruinsma [Pays-Bas] ; Raphael Valle-O Ate [Colombie] ; Consuelo Romero-Sánchez [Colombie] ; Inger Myrnes Hansen [Norvège] ; Fernando M. Pimentel-Santos [Portugal] ; Robert D. Inman [Canada] ; Javier Martin [Espagne] ; Maxime Breban [France] ; Bryan Paul Wordsworth [Royaume-Uni] ; John D. Reveille [États-Unis] ; David M. Evans [Royaume-Uni] ; Paul I W. De Bakker [Pays-Bas] ; Matthew A. Brown [Australie]Source :
- Nature communications [ 2041-1723 ] ; 2015.
Descripteurs français
- KwdFr :
- Aminopeptidases (génétique), Antigène HLA-B27 (génétique), Antigène HLA-B40 (génétique), Antigènes mineurs d'histocompatibilité, Complexe majeur d'histocompatibilité, Humains, Pelvispondylite rhumatismale (étiologie), Polymorphisme de nucléotide simple, Prédisposition génétique à une maladie, Épistasie, Études cas-témoins.
- MESH :
- génétique : Aminopeptidases, Antigène HLA-B27, Antigène HLA-B40.
- étiologie : Pelvispondylite rhumatismale.
- Antigènes mineurs d'histocompatibilité, Complexe majeur d'histocompatibilité, Humains, Polymorphisme de nucléotide simple, Prédisposition génétique à une maladie, Épistasie, Études cas-témoins.
English descriptors
- KwdEn :
- Aminopeptidases (genetics), Case-Control Studies, Epistasis, Genetic, Genetic Predisposition to Disease, HLA-B27 Antigen (genetics), HLA-B40 Antigen (genetics), Humans, Major Histocompatibility Complex, Minor Histocompatibility Antigens, Polymorphism, Single Nucleotide, Spondylitis, Ankylosing (etiology).
- MESH :
Abstract
Ankylosing spondylitis (AS) is a common, highly heritable, inflammatory arthritis for which HLA-B*27 is the major genetic risk factor, although its role in the aetiology of AS remains elusive. To better understand the genetic basis of the MHC susceptibility loci, we genotyped 7,264 MHC SNPs in 22,647 AS cases and controls of European descent. We impute SNPs, classical HLA alleles and amino-acid residues within HLA proteins, and tested these for association to AS status. Here we show that in addition to effects due to HLA-B*27 alleles, several other HLA-B alleles also affect susceptibility. After controlling for the associated haplotypes in HLA-B, we observe independent associations with variants in the HLA-A, HLA-DPB1 and HLA-DRB1 loci. We also demonstrate that the ERAP1 SNP rs30187 association is not restricted only to carriers of HLA-B*27 but also found in HLA-B*40:01 carriers independently of HLA-B*27 genotype.
DOI: 10.1038/ncomms8146
PubMed: 25994336
Affiliations:
- Arabie saoudite, Australie, Belgique, Canada, Colombie, Espagne, Finlande, France, Mexique, Norvège, Nouvelle-Zélande, Pays-Bas, Portugal, Royaume-Uni, États-Unis
- Angleterre, Angleterre de l'Est, Communauté de Madrid, Ontario, Utrecht (province), Île-de-France, Østlandet
- Cambridge, Madrid, Oslo, Toronto, Utrecht, Versailles
- Université de Cambridge, Université de Toronto, Université de Versailles-Saint-Quentin-en-Yvelines
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pubmed:25994336Le document en format XML
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Pulit</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht 3584, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht 3584</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Leo, Paul J" sort="Leo, Paul J" uniqKey="Leo P" first="Paul J" last="Leo">Paul J. Leo</name><affiliation wicri:level="1"><nlm:affiliation>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102</wicri:regionArea><wicri:noRegion>Brisbane 4102</wicri:noRegion></affiliation></author><author><name sortKey="Pointon, Jenny J" sort="Pointon, Jenny J" uniqKey="Pointon J" first="Jenny J" last="Pointon">Jenny J. 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Robinson</name><affiliation wicri:level="1"><nlm:affiliation>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102</wicri:regionArea><wicri:noRegion>Brisbane 4102</wicri:noRegion></affiliation></author><author><name sortKey="Weisman, Michael H" sort="Weisman, Michael H" uniqKey="Weisman M" first="Michael H" last="Weisman">Michael H. Weisman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine/Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine/Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California 90048</wicri:regionArea><wicri:noRegion>California 90048</wicri:noRegion></affiliation></author><author><name sortKey="Ward, Michael" sort="Ward, Michael" uniqKey="Ward M" first="Michael" last="Ward">Michael Ward</name><affiliation wicri:level="1"><nlm:affiliation>Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892-1468, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892-1468</wicri:regionArea><wicri:noRegion>Maryland 20892-1468</wicri:noRegion></affiliation></author><author><name sortKey="Gensler, Lianne S" sort="Gensler, Lianne S" uniqKey="Gensler L" first="Lianne S" last="Gensler">Lianne S. Gensler</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine/Rheumatology, University of California, San Francisco, California 94143, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine/Rheumatology, University of California, San Francisco, California 94143</wicri:regionArea><wicri:noRegion>California 94143</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Xiaodong" sort="Zhou, Xiaodong" uniqKey="Zhou X" first="Xiaodong" last="Zhou">Xiaodong Zhou</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston, Houston, Texas 77030</wicri:regionArea><wicri:noRegion>Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="Garchon, Henri Jean" sort="Garchon, Henri Jean" uniqKey="Garchon H" first="Henri-Jean" last="Garchon">Henri-Jean Garchon</name><affiliation wicri:level="4"><nlm:affiliation>1] INSERM UMR 1173, Université de Versailles Saint Quentin en Yvelines, Laboratoire d'excellence Inflamex, Saint-Quentn-En-Yvelines 78180, France [2] Genetics Division, Hôpital Ambroise Paré, AP-HP, and Université de Versailles Saint Quentin en Yvelines, Boulogne-Billancourt 78180, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] INSERM UMR 1173, Université de Versailles Saint Quentin en Yvelines, Laboratoire d'excellence Inflamex, Saint-Quentn-En-Yvelines 78180, France [2] Genetics Division, Hôpital Ambroise Paré, AP-HP, and Université de Versailles Saint Quentin en Yvelines, Boulogne-Billancourt 78180</wicri:regionArea><wicri:noRegion>78180</wicri:noRegion><orgName type="university">Université de Versailles-Saint-Quentin-en-Yvelines</orgName><placeName><settlement type="city">Versailles</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Chiocchia, Gilles" sort="Chiocchia, Gilles" uniqKey="Chiocchia G" first="Gilles" last="Chiocchia">Gilles Chiocchia</name><affiliation wicri:level="4"><nlm:affiliation>INSERM UMR 1173, Université de Versailles Saint Quentin en Yvelines, Laboratoire d'excellence Inflamex, Saint-Quentn-En-Yvelines 78180, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR 1173, Université de Versailles Saint Quentin en Yvelines, Laboratoire d'excellence Inflamex, Saint-Quentn-En-Yvelines 78180</wicri:regionArea><wicri:noRegion>78180</wicri:noRegion><orgName type="university">Université de Versailles-Saint-Quentin-en-Yvelines</orgName><placeName><settlement type="city">Versailles</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Nossent, Johannes" sort="Nossent, Johannes" uniqKey="Nossent J" first="Johannes" last="Nossent">Johannes Nossent</name><affiliation wicri:level="1"><nlm:affiliation>1] School of Medicine, University of Western Australia, Perth, WA 6009, Australia [2] Department of Rheumatology, Sir Charles Gairdner Hospital, Perth, WA 6009, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>1] School of Medicine, University of Western Australia, Perth, WA 6009, Australia [2] Department of Rheumatology, Sir Charles Gairdner Hospital, Perth, WA 6009</wicri:regionArea><wicri:noRegion>WA 6009</wicri:noRegion></affiliation></author><author><name sortKey="Lie, Benedicte A" sort="Lie, Benedicte A" uniqKey="Lie B" first="Benedicte A" last="Lie">Benedicte A. Lie</name><affiliation wicri:level="1"><nlm:affiliation>1] Department of Medical Genetics, University of Oslo and Oslo University Hospital, Oslo 0310, Norway [2] Department of Immunology, Oslo University Hospital, Oslo 0310, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>1] Department of Medical Genetics, University of Oslo and Oslo University Hospital, Oslo 0310, Norway [2] Department of Immunology, Oslo University Hospital, Oslo 0310</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="F Rre, Ystein" sort="F Rre, Ystein" uniqKey="F Rre " first=" Ystein" last="F Rre"> Ystein F Rre</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Oslo University Hospital, and University of Oslo, Oslo 0310, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Rheumatology, Oslo University Hospital, and University of Oslo, Oslo 0310</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Tuomilehto, Jaakko" sort="Tuomilehto, Jaakko" uniqKey="Tuomilehto J" first="Jaakko" last="Tuomilehto">Jaakko Tuomilehto</name><affiliation wicri:level="1"><nlm:affiliation>1] Department of Chronic Disease Prevention, National Institute for Health and Welfare, 00271 Helsinki, Finland [2] Centre for Vascular Prevention, Danube-University Krems, 3500 Krems, Austria [3] Diabetes Research Group, King Abdulaziz University, 21589 Jeddah, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>1] Department of Chronic Disease Prevention, National Institute for Health and Welfare, 00271 Helsinki, Finland [2] Centre for Vascular Prevention, Danube-University Krems, 3500 Krems, Austria [3] Diabetes Research Group, King Abdulaziz University, 21589 Jeddah</wicri:regionArea><wicri:noRegion>21589 Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Laiho, Kari" sort="Laiho, Kari" uniqKey="Laiho K" first="Kari" last="Laiho">Kari Laiho</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Paijat-Hame Central Hospital, Lahti, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Medicine, Paijat-Hame Central Hospital, Lahti</wicri:regionArea><wicri:noRegion>Lahti</wicri:noRegion></affiliation></author><author><name sortKey="Bradbury, Linda A" sort="Bradbury, Linda A" uniqKey="Bradbury L" first="Linda A" last="Bradbury">Linda A. Bradbury</name><affiliation wicri:level="1"><nlm:affiliation>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102</wicri:regionArea><wicri:noRegion>Brisbane 4102</wicri:noRegion></affiliation></author><author><name sortKey="Elewaut, Dirk" sort="Elewaut, Dirk" uniqKey="Elewaut D" first="Dirk" last="Elewaut">Dirk Elewaut</name><affiliation wicri:level="1"><nlm:affiliation>1] Department of Rheumatology, Gent University Hospital, Gent 9052, Belgium [2] VIB Inflammation Research Center, Ghent University, Gent 9052, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>1] Department of Rheumatology, Gent University Hospital, Gent 9052, Belgium [2] VIB Inflammation Research Center, Ghent University, Gent 9052</wicri:regionArea><wicri:noRegion>Gent 9052</wicri:noRegion></affiliation></author><author><name sortKey="Burgos Vargas, Ruben" sort="Burgos Vargas, Ruben" uniqKey="Burgos Vargas R" first="Ruben" last="Burgos-Vargas">Ruben Burgos-Vargas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hospital General de Mexico and Universidad Nacional Autonoma de Mexico, Mexico City 06726, Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>Department of Rheumatology, Hospital General de Mexico and Universidad Nacional Autonoma de Mexico, Mexico City 06726</wicri:regionArea><wicri:noRegion>Mexico City 06726</wicri:noRegion></affiliation></author><author><name sortKey="Stebbings, Simon" sort="Stebbings, Simon" uniqKey="Stebbings S" first="Simon" last="Stebbings">Simon Stebbings</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin 9016, New Zealand.</nlm:affiliation><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin 9016</wicri:regionArea><wicri:noRegion>Dunedin 9016</wicri:noRegion></affiliation></author><author><name sortKey="Appleton, Louise" sort="Appleton, Louise" uniqKey="Appleton L" first="Louise" last="Appleton">Louise Appleton</name><affiliation wicri:level="1"><nlm:affiliation>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD</wicri:regionArea><wicri:noRegion>Oxford OX3 7LD</wicri:noRegion></affiliation></author><author><name sortKey="Farrah, Claire" sort="Farrah, Claire" uniqKey="Farrah C" first="Claire" last="Farrah">Claire Farrah</name><affiliation wicri:level="1"><nlm:affiliation>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD</wicri:regionArea><wicri:noRegion>Oxford OX3 7LD</wicri:noRegion></affiliation></author><author><name sortKey="Lau, Jonathan" sort="Lau, Jonathan" uniqKey="Lau J" first="Jonathan" last="Lau">Jonathan Lau</name><affiliation wicri:level="1"><nlm:affiliation>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD</wicri:regionArea><wicri:noRegion>Oxford OX3 7LD</wicri:noRegion></affiliation></author><author><name sortKey="Haroon, Nigil" sort="Haroon, Nigil" uniqKey="Haroon N" first="Nigil" last="Haroon">Nigil Haroon</name><affiliation wicri:level="4"><nlm:affiliation>Division of Rheumatology, Toronto Western Hospital, University of Toronto, Toronto M5T2S8, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Rheumatology, Toronto Western Hospital, University of Toronto, Toronto M5T2S8</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Mulero, Juan" sort="Mulero, Juan" uniqKey="Mulero J" first="Juan" last="Mulero">Juan Mulero</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hospital Puerta de Hierro, Madrid 28222, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Rheumatology, Hospital Puerta de Hierro, Madrid 28222</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Blanco, Francisco J" sort="Blanco, Francisco J" uniqKey="Blanco F" first="Francisco J" last="Blanco">Francisco J. Blanco</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Complejo Hospitalario La Coruña, INIBIC, La Coruña 15006, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Rheumatology, Complejo Hospitalario La Coruña, INIBIC, La Coruña 15006</wicri:regionArea><wicri:noRegion>La Coruña 15006</wicri:noRegion></affiliation></author><author><name sortKey="Gonzalez Gay, Miguel A" sort="Gonzalez Gay, Miguel A" uniqKey="Gonzalez Gay M" first="Miguel A" last="Gonzalez-Gay">Miguel A. Gonzalez-Gay</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hospital Marques de Valcecillas, IFIMAV, Santander 39008, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Rheumatology, Hospital Marques de Valcecillas, IFIMAV, Santander 39008</wicri:regionArea><wicri:noRegion>Santander 39008</wicri:noRegion></affiliation></author><author><name sortKey="Lopez Larrea, C" sort="Lopez Larrea, C" uniqKey="Lopez Larrea C" first="C" last="Lopez-Larrea">C. Lopez-Larrea</name><affiliation wicri:level="1"><nlm:affiliation>1] Department of Immunology, Hospital Universitario Central de Asturias, Oviedo 33011, Spain [2] Fundación Renal 'Iñigo Álvarez de Toledo', Madrid 33011, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>1] Department of Immunology, Hospital Universitario Central de Asturias, Oviedo 33011, Spain [2] Fundación Renal 'Iñigo Álvarez de Toledo', Madrid 33011</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Bowness, Paul" sort="Bowness, Paul" uniqKey="Bowness P" first="Paul" last="Bowness">Paul Bowness</name><affiliation wicri:level="1"><nlm:affiliation>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD</wicri:regionArea><wicri:noRegion>Oxford OX3 7LD</wicri:noRegion></affiliation></author><author><name sortKey="Gaffney, Karl" sort="Gaffney, Karl" uniqKey="Gaffney K" first="Karl" last="Gaffney">Karl Gaffney</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Norfolk and Norwich University Hospital, Norwich NR4 7UY, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Rheumatology, Norfolk and Norwich University Hospital, Norwich NR4 7UY</wicri:regionArea><wicri:noRegion>Norwich NR4 7UY</wicri:noRegion></affiliation></author><author><name sortKey="Gaston, Hill" sort="Gaston, Hill" uniqKey="Gaston H" first="Hill" last="Gaston">Hill Gaston</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, University of Cambridge, Addenbrookes Hospital, Cambridge CB2 0SP, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Medicine, University of Cambridge, Addenbrookes Hospital, Cambridge CB2 0SP</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Gladman, Dafna D" sort="Gladman, Dafna D" uniqKey="Gladman D" first="Dafna D" last="Gladman">Dafna D. Gladman</name><affiliation wicri:level="4"><nlm:affiliation>1] Division of Rheumatology, University of Toronto, Toronto, ON M4N 3M5, Canada [2] Toronto Western Research Institute, Toronto ON M4N 3M5, Canada [3] Psoriatic Arthritis Program, University Health Network, Toronto ON M4N 3M5, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>1] Division of Rheumatology, University of Toronto, Toronto, ON M4N 3M5, Canada [2] Toronto Western Research Institute, Toronto ON M4N 3M5, Canada [3] Psoriatic Arthritis Program, University Health Network, Toronto ON M4N 3M5</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Rahman, Proton" sort="Rahman, Proton" uniqKey="Rahman P" first="Proton" last="Rahman">Proton Rahman</name><affiliation wicri:level="1"><nlm:affiliation>Memorial University of Newfoundland, Newfoundland NL A1B 3X9, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Memorial University of Newfoundland, Newfoundland NL A1B 3X9</wicri:regionArea><wicri:noRegion>Newfoundland NL A1B 3X9</wicri:noRegion></affiliation></author><author><name sortKey="Maksymowych, Walter P" sort="Maksymowych, Walter P" uniqKey="Maksymowych W" first="Walter P" last="Maksymowych">Walter P. Maksymowych</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, University of Alberta, Alberta T6G 2R7, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, University of Alberta, Alberta T6G 2R7</wicri:regionArea><wicri:noRegion>Alberta T6G 2R7</wicri:noRegion></affiliation></author><author><name sortKey="Crusius, J Bart A" sort="Crusius, J Bart A" uniqKey="Crusius J" first="J Bart A" last="Crusius">J Bart A. Crusius</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Microbiology and Infection Control, Laboratory of Immunogenetics, VU University Medical Center, Amsterdam 1081 BT, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Microbiology and Infection Control, Laboratory of Immunogenetics, VU University Medical Center, Amsterdam 1081 BT</wicri:regionArea><wicri:noRegion>Amsterdam 1081 BT</wicri:noRegion></affiliation></author><author><name sortKey="Van Der Horst Bruinsma, Irene E" sort="Van Der Horst Bruinsma, Irene E" uniqKey="Van Der Horst Bruinsma I" first="Irene E" last="Van Der Horst-Bruinsma">Irene E. Van Der Horst-Bruinsma</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, VU University Medical Centre, Amsterdam 1081 BT, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Rheumatology, VU University Medical Centre, Amsterdam 1081 BT</wicri:regionArea><wicri:noRegion>Amsterdam 1081 BT</wicri:noRegion></affiliation></author><author><name sortKey="Valle O Ate, Raphael" sort="Valle O Ate, Raphael" uniqKey="Valle O Ate R" first="Raphael" last="Valle-O Ate">Raphael Valle-O Ate</name><affiliation wicri:level="1"><nlm:affiliation>Spondyloarthropaty Group-Division of Rheumatology, Hospital Militar Central/Universidad de La Sabana, Transversal 3 # 49-00, Bogotá, NA, Colombia.</nlm:affiliation><country xml:lang="fr">Colombie</country><wicri:regionArea>Spondyloarthropaty Group-Division of Rheumatology, Hospital Militar Central/Universidad de La Sabana, Transversal 3 # 49-00, Bogotá, NA</wicri:regionArea><wicri:noRegion>NA</wicri:noRegion></affiliation></author><author><name sortKey="Romero Sanchez, Consuelo" sort="Romero Sanchez, Consuelo" uniqKey="Romero Sanchez C" first="Consuelo" last="Romero-Sánchez">Consuelo Romero-Sánchez</name><affiliation wicri:level="1"><nlm:affiliation>Spondyloarthropaty Group-Division of Rheumatology, Hospital Militar Central/Universidad de La Sabana, Transversal 3 # 49-00, Bogotá, NA, Colombia.</nlm:affiliation><country xml:lang="fr">Colombie</country><wicri:regionArea>Spondyloarthropaty Group-Division of Rheumatology, Hospital Militar Central/Universidad de La Sabana, Transversal 3 # 49-00, Bogotá, NA</wicri:regionArea><wicri:noRegion>NA</wicri:noRegion></affiliation></author><author><name sortKey="Hansen, Inger Myrnes" sort="Hansen, Inger Myrnes" uniqKey="Hansen I" first="Inger Myrnes" last="Hansen">Inger Myrnes Hansen</name><affiliation wicri:level="1"><nlm:affiliation>Helgelandssykehuset, 8613 Mo i Rana, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Helgelandssykehuset, 8613 Mo i Rana</wicri:regionArea><wicri:noRegion>8613 Mo i Rana</wicri:noRegion></affiliation></author><author><name sortKey="Pimentel Santos, Fernando M" sort="Pimentel Santos, Fernando M" uniqKey="Pimentel Santos F" first="Fernando M" last="Pimentel-Santos">Fernando M. Pimentel-Santos</name><affiliation wicri:level="1"><nlm:affiliation>Chronic Diseases Research Centre (CEDOC), Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa 1169-056, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Chronic Diseases Research Centre (CEDOC), Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa 1169-056</wicri:regionArea><wicri:noRegion>Lisboa 1169-056</wicri:noRegion></affiliation></author><author><name sortKey="Inman, Robert D" sort="Inman, Robert D" uniqKey="Inman R" first="Robert D" last="Inman">Robert D. Inman</name><affiliation wicri:level="4"><nlm:affiliation>Division of Rheumatology, Toronto Western Hospital, University of Toronto, Toronto M5T2S8, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Rheumatology, Toronto Western Hospital, University of Toronto, Toronto M5T2S8</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Martin, Javier" sort="Martin, Javier" uniqKey="Martin J" first="Javier" last="Martin">Javier Martin</name><affiliation wicri:level="1"><nlm:affiliation>Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones-Científicas, Granada 18100, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones-Científicas, Granada 18100</wicri:regionArea><wicri:noRegion>Granada 18100</wicri:noRegion></affiliation></author><author><name sortKey="Breban, Maxime" sort="Breban, Maxime" uniqKey="Breban M" first="Maxime" last="Breban">Maxime Breban</name><affiliation wicri:level="4"><nlm:affiliation>1] INSERM UMR 1173, Université de Versailles Saint Quentin en Yvelines, Laboratoire d'excellence Inflamex, Saint-Quentn-En-Yvelines 78180, France [2] Division of Rheumatology, Hôpital Ambroise Paré, AP-HP, and Université de Versailles Saint Quentin en Yvelines, Boulogne-Billancourt 92100, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] INSERM UMR 1173, Université de Versailles Saint Quentin en Yvelines, Laboratoire d'excellence Inflamex, Saint-Quentn-En-Yvelines 78180, France [2] Division of Rheumatology, Hôpital Ambroise Paré, AP-HP, and Université de Versailles Saint Quentin en Yvelines, Boulogne-Billancourt 92100</wicri:regionArea><wicri:noRegion>92100</wicri:noRegion><orgName type="university">Université de Versailles-Saint-Quentin-en-Yvelines</orgName><placeName><settlement type="city">Versailles</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Wordsworth, Bryan Paul" sort="Wordsworth, Bryan Paul" uniqKey="Wordsworth B" first="Bryan Paul" last="Wordsworth">Bryan Paul Wordsworth</name><affiliation wicri:level="1"><nlm:affiliation>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD</wicri:regionArea><wicri:noRegion>Oxford OX3 7LD</wicri:noRegion></affiliation></author><author><name sortKey="Reveille, John D" sort="Reveille, John D" uniqKey="Reveille J" first="John D" last="Reveille">John D. Reveille</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston, Houston, Texas 77030</wicri:regionArea><wicri:noRegion>Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M" last="Evans">David M. Evans</name><affiliation wicri:level="1"><nlm:affiliation>1] University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102, Australia [2] MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK [3] School of Social and Community Medicine, University of Bristol, Bristol, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>1] University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102, Australia [2] MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK [3] School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="De Bakker, Paul I W" sort="De Bakker, Paul I W" uniqKey="De Bakker P" first="Paul I W" last="De Bakker">Paul I W. De Bakker</name><affiliation wicri:level="3"><nlm:affiliation>1] Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht 3584, The Netherlands [2] Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>1] Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht 3584, The Netherlands [2] Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Brown, Matthew A" sort="Brown, Matthew A" uniqKey="Brown M" first="Matthew A" last="Brown">Matthew A. Brown</name><affiliation wicri:level="1"><nlm:affiliation>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102</wicri:regionArea><wicri:noRegion>Brisbane 4102</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25994336</idno><idno type="pmid">25994336</idno><idno type="doi">10.1038/ncomms8146</idno><idno type="wicri:Area/PubMed/Corpus">002D51</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002D51</idno><idno type="wicri:Area/PubMed/Curation">002C76</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002C76</idno><idno type="wicri:Area/PubMed/Checkpoint">002C76</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002C76</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1.</title><author><name sortKey="Cortes, Adrian" sort="Cortes, Adrian" uniqKey="Cortes A" first="Adrian" last="Cortes">Adrian Cortes</name><affiliation wicri:level="1"><nlm:affiliation>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102</wicri:regionArea><wicri:noRegion>Brisbane 4102</wicri:noRegion></affiliation></author><author><name sortKey="Pulit, Sara L" sort="Pulit, Sara L" uniqKey="Pulit S" first="Sara L" last="Pulit">Sara L. Pulit</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht 3584, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht 3584</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Leo, Paul J" sort="Leo, Paul J" uniqKey="Leo P" first="Paul J" last="Leo">Paul J. Leo</name><affiliation wicri:level="1"><nlm:affiliation>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102</wicri:regionArea><wicri:noRegion>Brisbane 4102</wicri:noRegion></affiliation></author><author><name sortKey="Pointon, Jenny J" sort="Pointon, Jenny J" uniqKey="Pointon J" first="Jenny J" last="Pointon">Jenny J. Pointon</name><affiliation wicri:level="1"><nlm:affiliation>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD</wicri:regionArea><wicri:noRegion>Oxford OX3 7LD</wicri:noRegion></affiliation></author><author><name sortKey="Robinson, Philip C" sort="Robinson, Philip C" uniqKey="Robinson P" first="Philip C" last="Robinson">Philip C. Robinson</name><affiliation wicri:level="1"><nlm:affiliation>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102</wicri:regionArea><wicri:noRegion>Brisbane 4102</wicri:noRegion></affiliation></author><author><name sortKey="Weisman, Michael H" sort="Weisman, Michael H" uniqKey="Weisman M" first="Michael H" last="Weisman">Michael H. Weisman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine/Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine/Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California 90048</wicri:regionArea><wicri:noRegion>California 90048</wicri:noRegion></affiliation></author><author><name sortKey="Ward, Michael" sort="Ward, Michael" uniqKey="Ward M" first="Michael" last="Ward">Michael Ward</name><affiliation wicri:level="1"><nlm:affiliation>Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892-1468, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892-1468</wicri:regionArea><wicri:noRegion>Maryland 20892-1468</wicri:noRegion></affiliation></author><author><name sortKey="Gensler, Lianne S" sort="Gensler, Lianne S" uniqKey="Gensler L" first="Lianne S" last="Gensler">Lianne S. Gensler</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine/Rheumatology, University of California, San Francisco, California 94143, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine/Rheumatology, University of California, San Francisco, California 94143</wicri:regionArea><wicri:noRegion>California 94143</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Xiaodong" sort="Zhou, Xiaodong" uniqKey="Zhou X" first="Xiaodong" last="Zhou">Xiaodong Zhou</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston, Houston, Texas 77030</wicri:regionArea><wicri:noRegion>Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="Garchon, Henri Jean" sort="Garchon, Henri Jean" uniqKey="Garchon H" first="Henri-Jean" last="Garchon">Henri-Jean Garchon</name><affiliation wicri:level="4"><nlm:affiliation>1] INSERM UMR 1173, Université de Versailles Saint Quentin en Yvelines, Laboratoire d'excellence Inflamex, Saint-Quentn-En-Yvelines 78180, France [2] Genetics Division, Hôpital Ambroise Paré, AP-HP, and Université de Versailles Saint Quentin en Yvelines, Boulogne-Billancourt 78180, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] INSERM UMR 1173, Université de Versailles Saint Quentin en Yvelines, Laboratoire d'excellence Inflamex, Saint-Quentn-En-Yvelines 78180, France [2] Genetics Division, Hôpital Ambroise Paré, AP-HP, and Université de Versailles Saint Quentin en Yvelines, Boulogne-Billancourt 78180</wicri:regionArea><wicri:noRegion>78180</wicri:noRegion><orgName type="university">Université de Versailles-Saint-Quentin-en-Yvelines</orgName><placeName><settlement type="city">Versailles</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Chiocchia, Gilles" sort="Chiocchia, Gilles" uniqKey="Chiocchia G" first="Gilles" last="Chiocchia">Gilles Chiocchia</name><affiliation wicri:level="4"><nlm:affiliation>INSERM UMR 1173, Université de Versailles Saint Quentin en Yvelines, Laboratoire d'excellence Inflamex, Saint-Quentn-En-Yvelines 78180, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR 1173, Université de Versailles Saint Quentin en Yvelines, Laboratoire d'excellence Inflamex, Saint-Quentn-En-Yvelines 78180</wicri:regionArea><wicri:noRegion>78180</wicri:noRegion><orgName type="university">Université de Versailles-Saint-Quentin-en-Yvelines</orgName><placeName><settlement type="city">Versailles</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Nossent, Johannes" sort="Nossent, Johannes" uniqKey="Nossent J" first="Johannes" last="Nossent">Johannes Nossent</name><affiliation wicri:level="1"><nlm:affiliation>1] School of Medicine, University of Western Australia, Perth, WA 6009, Australia [2] Department of Rheumatology, Sir Charles Gairdner Hospital, Perth, WA 6009, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>1] School of Medicine, University of Western Australia, Perth, WA 6009, Australia [2] Department of Rheumatology, Sir Charles Gairdner Hospital, Perth, WA 6009</wicri:regionArea><wicri:noRegion>WA 6009</wicri:noRegion></affiliation></author><author><name sortKey="Lie, Benedicte A" sort="Lie, Benedicte A" uniqKey="Lie B" first="Benedicte A" last="Lie">Benedicte A. Lie</name><affiliation wicri:level="1"><nlm:affiliation>1] Department of Medical Genetics, University of Oslo and Oslo University Hospital, Oslo 0310, Norway [2] Department of Immunology, Oslo University Hospital, Oslo 0310, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>1] Department of Medical Genetics, University of Oslo and Oslo University Hospital, Oslo 0310, Norway [2] Department of Immunology, Oslo University Hospital, Oslo 0310</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="F Rre, Ystein" sort="F Rre, Ystein" uniqKey="F Rre " first=" Ystein" last="F Rre"> Ystein F Rre</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Oslo University Hospital, and University of Oslo, Oslo 0310, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Rheumatology, Oslo University Hospital, and University of Oslo, Oslo 0310</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Tuomilehto, Jaakko" sort="Tuomilehto, Jaakko" uniqKey="Tuomilehto J" first="Jaakko" last="Tuomilehto">Jaakko Tuomilehto</name><affiliation wicri:level="1"><nlm:affiliation>1] Department of Chronic Disease Prevention, National Institute for Health and Welfare, 00271 Helsinki, Finland [2] Centre for Vascular Prevention, Danube-University Krems, 3500 Krems, Austria [3] Diabetes Research Group, King Abdulaziz University, 21589 Jeddah, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>1] Department of Chronic Disease Prevention, National Institute for Health and Welfare, 00271 Helsinki, Finland [2] Centre for Vascular Prevention, Danube-University Krems, 3500 Krems, Austria [3] Diabetes Research Group, King Abdulaziz University, 21589 Jeddah</wicri:regionArea><wicri:noRegion>21589 Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Laiho, Kari" sort="Laiho, Kari" uniqKey="Laiho K" first="Kari" last="Laiho">Kari Laiho</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Paijat-Hame Central Hospital, Lahti, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Medicine, Paijat-Hame Central Hospital, Lahti</wicri:regionArea><wicri:noRegion>Lahti</wicri:noRegion></affiliation></author><author><name sortKey="Bradbury, Linda A" sort="Bradbury, Linda A" uniqKey="Bradbury L" first="Linda A" last="Bradbury">Linda A. Bradbury</name><affiliation wicri:level="1"><nlm:affiliation>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102</wicri:regionArea><wicri:noRegion>Brisbane 4102</wicri:noRegion></affiliation></author><author><name sortKey="Elewaut, Dirk" sort="Elewaut, Dirk" uniqKey="Elewaut D" first="Dirk" last="Elewaut">Dirk Elewaut</name><affiliation wicri:level="1"><nlm:affiliation>1] Department of Rheumatology, Gent University Hospital, Gent 9052, Belgium [2] VIB Inflammation Research Center, Ghent University, Gent 9052, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>1] Department of Rheumatology, Gent University Hospital, Gent 9052, Belgium [2] VIB Inflammation Research Center, Ghent University, Gent 9052</wicri:regionArea><wicri:noRegion>Gent 9052</wicri:noRegion></affiliation></author><author><name sortKey="Burgos Vargas, Ruben" sort="Burgos Vargas, Ruben" uniqKey="Burgos Vargas R" first="Ruben" last="Burgos-Vargas">Ruben Burgos-Vargas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hospital General de Mexico and Universidad Nacional Autonoma de Mexico, Mexico City 06726, Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>Department of Rheumatology, Hospital General de Mexico and Universidad Nacional Autonoma de Mexico, Mexico City 06726</wicri:regionArea><wicri:noRegion>Mexico City 06726</wicri:noRegion></affiliation></author><author><name sortKey="Stebbings, Simon" sort="Stebbings, Simon" uniqKey="Stebbings S" first="Simon" last="Stebbings">Simon Stebbings</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin 9016, New Zealand.</nlm:affiliation><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin 9016</wicri:regionArea><wicri:noRegion>Dunedin 9016</wicri:noRegion></affiliation></author><author><name sortKey="Appleton, Louise" sort="Appleton, Louise" uniqKey="Appleton L" first="Louise" last="Appleton">Louise Appleton</name><affiliation wicri:level="1"><nlm:affiliation>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD</wicri:regionArea><wicri:noRegion>Oxford OX3 7LD</wicri:noRegion></affiliation></author><author><name sortKey="Farrah, Claire" sort="Farrah, Claire" uniqKey="Farrah C" first="Claire" last="Farrah">Claire Farrah</name><affiliation wicri:level="1"><nlm:affiliation>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD</wicri:regionArea><wicri:noRegion>Oxford OX3 7LD</wicri:noRegion></affiliation></author><author><name sortKey="Lau, Jonathan" sort="Lau, Jonathan" uniqKey="Lau J" first="Jonathan" last="Lau">Jonathan Lau</name><affiliation wicri:level="1"><nlm:affiliation>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD</wicri:regionArea><wicri:noRegion>Oxford OX3 7LD</wicri:noRegion></affiliation></author><author><name sortKey="Haroon, Nigil" sort="Haroon, Nigil" uniqKey="Haroon N" first="Nigil" last="Haroon">Nigil Haroon</name><affiliation wicri:level="4"><nlm:affiliation>Division of Rheumatology, Toronto Western Hospital, University of Toronto, Toronto M5T2S8, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Rheumatology, Toronto Western Hospital, University of Toronto, Toronto M5T2S8</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Mulero, Juan" sort="Mulero, Juan" uniqKey="Mulero J" first="Juan" last="Mulero">Juan Mulero</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hospital Puerta de Hierro, Madrid 28222, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Rheumatology, Hospital Puerta de Hierro, Madrid 28222</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Blanco, Francisco J" sort="Blanco, Francisco J" uniqKey="Blanco F" first="Francisco J" last="Blanco">Francisco J. Blanco</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Complejo Hospitalario La Coruña, INIBIC, La Coruña 15006, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Rheumatology, Complejo Hospitalario La Coruña, INIBIC, La Coruña 15006</wicri:regionArea><wicri:noRegion>La Coruña 15006</wicri:noRegion></affiliation></author><author><name sortKey="Gonzalez Gay, Miguel A" sort="Gonzalez Gay, Miguel A" uniqKey="Gonzalez Gay M" first="Miguel A" last="Gonzalez-Gay">Miguel A. Gonzalez-Gay</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hospital Marques de Valcecillas, IFIMAV, Santander 39008, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Rheumatology, Hospital Marques de Valcecillas, IFIMAV, Santander 39008</wicri:regionArea><wicri:noRegion>Santander 39008</wicri:noRegion></affiliation></author><author><name sortKey="Lopez Larrea, C" sort="Lopez Larrea, C" uniqKey="Lopez Larrea C" first="C" last="Lopez-Larrea">C. Lopez-Larrea</name><affiliation wicri:level="1"><nlm:affiliation>1] Department of Immunology, Hospital Universitario Central de Asturias, Oviedo 33011, Spain [2] Fundación Renal 'Iñigo Álvarez de Toledo', Madrid 33011, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>1] Department of Immunology, Hospital Universitario Central de Asturias, Oviedo 33011, Spain [2] Fundación Renal 'Iñigo Álvarez de Toledo', Madrid 33011</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Bowness, Paul" sort="Bowness, Paul" uniqKey="Bowness P" first="Paul" last="Bowness">Paul Bowness</name><affiliation wicri:level="1"><nlm:affiliation>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD</wicri:regionArea><wicri:noRegion>Oxford OX3 7LD</wicri:noRegion></affiliation></author><author><name sortKey="Gaffney, Karl" sort="Gaffney, Karl" uniqKey="Gaffney K" first="Karl" last="Gaffney">Karl Gaffney</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Norfolk and Norwich University Hospital, Norwich NR4 7UY, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Rheumatology, Norfolk and Norwich University Hospital, Norwich NR4 7UY</wicri:regionArea><wicri:noRegion>Norwich NR4 7UY</wicri:noRegion></affiliation></author><author><name sortKey="Gaston, Hill" sort="Gaston, Hill" uniqKey="Gaston H" first="Hill" last="Gaston">Hill Gaston</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, University of Cambridge, Addenbrookes Hospital, Cambridge CB2 0SP, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Medicine, University of Cambridge, Addenbrookes Hospital, Cambridge CB2 0SP</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Gladman, Dafna D" sort="Gladman, Dafna D" uniqKey="Gladman D" first="Dafna D" last="Gladman">Dafna D. Gladman</name><affiliation wicri:level="4"><nlm:affiliation>1] Division of Rheumatology, University of Toronto, Toronto, ON M4N 3M5, Canada [2] Toronto Western Research Institute, Toronto ON M4N 3M5, Canada [3] Psoriatic Arthritis Program, University Health Network, Toronto ON M4N 3M5, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>1] Division of Rheumatology, University of Toronto, Toronto, ON M4N 3M5, Canada [2] Toronto Western Research Institute, Toronto ON M4N 3M5, Canada [3] Psoriatic Arthritis Program, University Health Network, Toronto ON M4N 3M5</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Rahman, Proton" sort="Rahman, Proton" uniqKey="Rahman P" first="Proton" last="Rahman">Proton Rahman</name><affiliation wicri:level="1"><nlm:affiliation>Memorial University of Newfoundland, Newfoundland NL A1B 3X9, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Memorial University of Newfoundland, Newfoundland NL A1B 3X9</wicri:regionArea><wicri:noRegion>Newfoundland NL A1B 3X9</wicri:noRegion></affiliation></author><author><name sortKey="Maksymowych, Walter P" sort="Maksymowych, Walter P" uniqKey="Maksymowych W" first="Walter P" last="Maksymowych">Walter P. Maksymowych</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, University of Alberta, Alberta T6G 2R7, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, University of Alberta, Alberta T6G 2R7</wicri:regionArea><wicri:noRegion>Alberta T6G 2R7</wicri:noRegion></affiliation></author><author><name sortKey="Crusius, J Bart A" sort="Crusius, J Bart A" uniqKey="Crusius J" first="J Bart A" last="Crusius">J Bart A. Crusius</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Microbiology and Infection Control, Laboratory of Immunogenetics, VU University Medical Center, Amsterdam 1081 BT, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Microbiology and Infection Control, Laboratory of Immunogenetics, VU University Medical Center, Amsterdam 1081 BT</wicri:regionArea><wicri:noRegion>Amsterdam 1081 BT</wicri:noRegion></affiliation></author><author><name sortKey="Van Der Horst Bruinsma, Irene E" sort="Van Der Horst Bruinsma, Irene E" uniqKey="Van Der Horst Bruinsma I" first="Irene E" last="Van Der Horst-Bruinsma">Irene E. Van Der Horst-Bruinsma</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, VU University Medical Centre, Amsterdam 1081 BT, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Rheumatology, VU University Medical Centre, Amsterdam 1081 BT</wicri:regionArea><wicri:noRegion>Amsterdam 1081 BT</wicri:noRegion></affiliation></author><author><name sortKey="Valle O Ate, Raphael" sort="Valle O Ate, Raphael" uniqKey="Valle O Ate R" first="Raphael" last="Valle-O Ate">Raphael Valle-O Ate</name><affiliation wicri:level="1"><nlm:affiliation>Spondyloarthropaty Group-Division of Rheumatology, Hospital Militar Central/Universidad de La Sabana, Transversal 3 # 49-00, Bogotá, NA, Colombia.</nlm:affiliation><country xml:lang="fr">Colombie</country><wicri:regionArea>Spondyloarthropaty Group-Division of Rheumatology, Hospital Militar Central/Universidad de La Sabana, Transversal 3 # 49-00, Bogotá, NA</wicri:regionArea><wicri:noRegion>NA</wicri:noRegion></affiliation></author><author><name sortKey="Romero Sanchez, Consuelo" sort="Romero Sanchez, Consuelo" uniqKey="Romero Sanchez C" first="Consuelo" last="Romero-Sánchez">Consuelo Romero-Sánchez</name><affiliation wicri:level="1"><nlm:affiliation>Spondyloarthropaty Group-Division of Rheumatology, Hospital Militar Central/Universidad de La Sabana, Transversal 3 # 49-00, Bogotá, NA, Colombia.</nlm:affiliation><country xml:lang="fr">Colombie</country><wicri:regionArea>Spondyloarthropaty Group-Division of Rheumatology, Hospital Militar Central/Universidad de La Sabana, Transversal 3 # 49-00, Bogotá, NA</wicri:regionArea><wicri:noRegion>NA</wicri:noRegion></affiliation></author><author><name sortKey="Hansen, Inger Myrnes" sort="Hansen, Inger Myrnes" uniqKey="Hansen I" first="Inger Myrnes" last="Hansen">Inger Myrnes Hansen</name><affiliation wicri:level="1"><nlm:affiliation>Helgelandssykehuset, 8613 Mo i Rana, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Helgelandssykehuset, 8613 Mo i Rana</wicri:regionArea><wicri:noRegion>8613 Mo i Rana</wicri:noRegion></affiliation></author><author><name sortKey="Pimentel Santos, Fernando M" sort="Pimentel Santos, Fernando M" uniqKey="Pimentel Santos F" first="Fernando M" last="Pimentel-Santos">Fernando M. Pimentel-Santos</name><affiliation wicri:level="1"><nlm:affiliation>Chronic Diseases Research Centre (CEDOC), Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa 1169-056, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Chronic Diseases Research Centre (CEDOC), Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa 1169-056</wicri:regionArea><wicri:noRegion>Lisboa 1169-056</wicri:noRegion></affiliation></author><author><name sortKey="Inman, Robert D" sort="Inman, Robert D" uniqKey="Inman R" first="Robert D" last="Inman">Robert D. Inman</name><affiliation wicri:level="4"><nlm:affiliation>Division of Rheumatology, Toronto Western Hospital, University of Toronto, Toronto M5T2S8, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Rheumatology, Toronto Western Hospital, University of Toronto, Toronto M5T2S8</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Martin, Javier" sort="Martin, Javier" uniqKey="Martin J" first="Javier" last="Martin">Javier Martin</name><affiliation wicri:level="1"><nlm:affiliation>Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones-Científicas, Granada 18100, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones-Científicas, Granada 18100</wicri:regionArea><wicri:noRegion>Granada 18100</wicri:noRegion></affiliation></author><author><name sortKey="Breban, Maxime" sort="Breban, Maxime" uniqKey="Breban M" first="Maxime" last="Breban">Maxime Breban</name><affiliation wicri:level="4"><nlm:affiliation>1] INSERM UMR 1173, Université de Versailles Saint Quentin en Yvelines, Laboratoire d'excellence Inflamex, Saint-Quentn-En-Yvelines 78180, France [2] Division of Rheumatology, Hôpital Ambroise Paré, AP-HP, and Université de Versailles Saint Quentin en Yvelines, Boulogne-Billancourt 92100, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>1] INSERM UMR 1173, Université de Versailles Saint Quentin en Yvelines, Laboratoire d'excellence Inflamex, Saint-Quentn-En-Yvelines 78180, France [2] Division of Rheumatology, Hôpital Ambroise Paré, AP-HP, and Université de Versailles Saint Quentin en Yvelines, Boulogne-Billancourt 92100</wicri:regionArea><wicri:noRegion>92100</wicri:noRegion><orgName type="university">Université de Versailles-Saint-Quentin-en-Yvelines</orgName><placeName><settlement type="city">Versailles</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Wordsworth, Bryan Paul" sort="Wordsworth, Bryan Paul" uniqKey="Wordsworth B" first="Bryan Paul" last="Wordsworth">Bryan Paul Wordsworth</name><affiliation wicri:level="1"><nlm:affiliation>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD</wicri:regionArea><wicri:noRegion>Oxford OX3 7LD</wicri:noRegion></affiliation></author><author><name sortKey="Reveille, John D" sort="Reveille, John D" uniqKey="Reveille J" first="John D" last="Reveille">John D. Reveille</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston, Houston, Texas 77030</wicri:regionArea><wicri:noRegion>Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M" last="Evans">David M. Evans</name><affiliation wicri:level="1"><nlm:affiliation>1] University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102, Australia [2] MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK [3] School of Social and Community Medicine, University of Bristol, Bristol, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>1] University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102, Australia [2] MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK [3] School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="De Bakker, Paul I W" sort="De Bakker, Paul I W" uniqKey="De Bakker P" first="Paul I W" last="De Bakker">Paul I W. De Bakker</name><affiliation wicri:level="3"><nlm:affiliation>1] Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht 3584, The Netherlands [2] Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>1] Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht 3584, The Netherlands [2] Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Brown, Matthew A" sort="Brown, Matthew A" uniqKey="Brown M" first="Matthew A" last="Brown">Matthew A. Brown</name><affiliation wicri:level="1"><nlm:affiliation>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102</wicri:regionArea><wicri:noRegion>Brisbane 4102</wicri:noRegion></affiliation></author></analytic><series><title level="j">Nature communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aminopeptidases (genetics)</term><term>Case-Control Studies</term><term>Epistasis, Genetic</term><term>Genetic Predisposition to Disease</term><term>HLA-B27 Antigen (genetics)</term><term>HLA-B40 Antigen (genetics)</term><term>Humans</term><term>Major Histocompatibility Complex</term><term>Minor Histocompatibility Antigens</term><term>Polymorphism, Single Nucleotide</term><term>Spondylitis, Ankylosing (etiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Aminopeptidases (génétique)</term><term>Antigène HLA-B27 (génétique)</term><term>Antigène HLA-B40 (génétique)</term><term>Antigènes mineurs d'histocompatibilité</term><term>Complexe majeur d'histocompatibilité</term><term>Humains</term><term>Pelvispondylite rhumatismale (étiologie)</term><term>Polymorphisme de nucléotide simple</term><term>Prédisposition génétique à une maladie</term><term>Épistasie</term><term>Études cas-témoins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Aminopeptidases</term><term>HLA-B27 Antigen</term><term>HLA-B40 Antigen</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Spondylitis, Ankylosing</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Aminopeptidases</term><term>Antigène HLA-B27</term><term>Antigène HLA-B40</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Pelvispondylite rhumatismale</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Case-Control Studies</term><term>Epistasis, Genetic</term><term>Genetic Predisposition to Disease</term><term>Humans</term><term>Major Histocompatibility Complex</term><term>Minor Histocompatibility Antigens</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Antigènes mineurs d'histocompatibilité</term><term>Complexe majeur d'histocompatibilité</term><term>Humains</term><term>Polymorphisme de nucléotide simple</term><term>Prédisposition génétique à une maladie</term><term>Épistasie</term><term>Études cas-témoins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Ankylosing spondylitis (AS) is a common, highly heritable, inflammatory arthritis for which HLA-B*27 is the major genetic risk factor, although its role in the aetiology of AS remains elusive. To better understand the genetic basis of the MHC susceptibility loci, we genotyped 7,264 MHC SNPs in 22,647 AS cases and controls of European descent. We impute SNPs, classical HLA alleles and amino-acid residues within HLA proteins, and tested these for association to AS status. Here we show that in addition to effects due to HLA-B*27 alleles, several other HLA-B alleles also affect susceptibility. After controlling for the associated haplotypes in HLA-B, we observe independent associations with variants in the HLA-A, HLA-DPB1 and HLA-DRB1 loci. We also demonstrate that the ERAP1 SNP rs30187 association is not restricted only to carriers of HLA-B*27 but also found in HLA-B*40:01 carriers independently of HLA-B*27 genotype.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25994336</PMID><DateCreated><Year>2015</Year><Month>05</Month><Day>21</Day></DateCreated><DateCompleted><Year>2016</Year><Month>04</Month><Day>11</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2041-1723</ISSN><JournalIssue CitedMedium="Internet"><Volume>6</Volume><PubDate><Year>2015</Year><Month>May</Month><Day>21</Day></PubDate></JournalIssue><Title>Nature communications</Title><ISOAbbreviation>Nat Commun</ISOAbbreviation></Journal><ArticleTitle>Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1.</ArticleTitle><Pagination><MedlinePgn>7146</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/ncomms8146</ELocationID><Abstract><AbstractText>Ankylosing spondylitis (AS) is a common, highly heritable, inflammatory arthritis for which HLA-B*27 is the major genetic risk factor, although its role in the aetiology of AS remains elusive. To better understand the genetic basis of the MHC susceptibility loci, we genotyped 7,264 MHC SNPs in 22,647 AS cases and controls of European descent. We impute SNPs, classical HLA alleles and amino-acid residues within HLA proteins, and tested these for association to AS status. Here we show that in addition to effects due to HLA-B*27 alleles, several other HLA-B alleles also affect susceptibility. After controlling for the associated haplotypes in HLA-B, we observe independent associations with variants in the HLA-A, HLA-DPB1 and HLA-DRB1 loci. We also demonstrate that the ERAP1 SNP rs30187 association is not restricted only to carriers of HLA-B*27 but also found in HLA-B*40:01 carriers independently of HLA-B*27 genotype.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cortes</LastName><ForeName>Adrian</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pulit</LastName><ForeName>Sara L</ForeName><Initials>SL</Initials><AffiliationInfo><Affiliation>Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht 3584, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leo</LastName><ForeName>Paul J</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pointon</LastName><ForeName>Jenny J</ForeName><Initials>JJ</Initials><AffiliationInfo><Affiliation>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Robinson</LastName><ForeName>Philip C</ForeName><Initials>PC</Initials><AffiliationInfo><Affiliation>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weisman</LastName><ForeName>Michael H</ForeName><Initials>MH</Initials><AffiliationInfo><Affiliation>Department of Medicine/Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ward</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892-1468, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gensler</LastName><ForeName>Lianne S</ForeName><Initials>LS</Initials><AffiliationInfo><Affiliation>Department of Medicine/Rheumatology, University of California, San Francisco, California 94143, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Xiaodong</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Garchon</LastName><ForeName>Henri-Jean</ForeName><Initials>HJ</Initials><AffiliationInfo><Affiliation>1] INSERM UMR 1173, Université de Versailles Saint Quentin en Yvelines, Laboratoire d'excellence Inflamex, Saint-Quentn-En-Yvelines 78180, France [2] Genetics Division, Hôpital Ambroise Paré, AP-HP, and Université de Versailles Saint Quentin en Yvelines, Boulogne-Billancourt 78180, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chiocchia</LastName><ForeName>Gilles</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>INSERM UMR 1173, Université de Versailles Saint Quentin en Yvelines, Laboratoire d'excellence Inflamex, Saint-Quentn-En-Yvelines 78180, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nossent</LastName><ForeName>Johannes</ForeName><Initials>J</Initials><Identifier Source="ORCID">0000000228337997</Identifier><AffiliationInfo><Affiliation>1] School of Medicine, University of Western Australia, Perth, WA 6009, Australia [2] Department of Rheumatology, Sir Charles Gairdner Hospital, Perth, WA 6009, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lie</LastName><ForeName>Benedicte A</ForeName><Initials>BA</Initials><AffiliationInfo><Affiliation>1] Department of Medical Genetics, University of Oslo and Oslo University Hospital, Oslo 0310, Norway [2] Department of Immunology, Oslo University Hospital, Oslo 0310, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Førre</LastName><ForeName>Øystein</ForeName><Initials>Ø</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Oslo University Hospital, and University of Oslo, Oslo 0310, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tuomilehto</LastName><ForeName>Jaakko</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>1] Department of Chronic Disease Prevention, National Institute for Health and Welfare, 00271 Helsinki, Finland [2] Centre for Vascular Prevention, Danube-University Krems, 3500 Krems, Austria [3] Diabetes Research Group, King Abdulaziz University, 21589 Jeddah, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Laiho</LastName><ForeName>Kari</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Medicine, Paijat-Hame Central Hospital, Lahti, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bradbury</LastName><ForeName>Linda A</ForeName><Initials>LA</Initials><AffiliationInfo><Affiliation>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Elewaut</LastName><ForeName>Dirk</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>1] Department of Rheumatology, Gent University Hospital, Gent 9052, Belgium [2] VIB Inflammation Research Center, Ghent University, Gent 9052, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Burgos-Vargas</LastName><ForeName>Ruben</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Hospital General de Mexico and Universidad Nacional Autonoma de Mexico, Mexico City 06726, Mexico.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stebbings</LastName><ForeName>Simon</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin 9016, New Zealand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Appleton</LastName><ForeName>Louise</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Farrah</LastName><ForeName>Claire</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lau</LastName><ForeName>Jonathan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haroon</LastName><ForeName>Nigil</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Division of Rheumatology, Toronto Western Hospital, University of Toronto, Toronto M5T2S8, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mulero</LastName><ForeName>Juan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Hospital Puerta de Hierro, Madrid 28222, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blanco</LastName><ForeName>Francisco J</ForeName><Initials>FJ</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Complejo Hospitalario La Coruña, INIBIC, La Coruña 15006, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gonzalez-Gay</LastName><ForeName>Miguel A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Hospital Marques de Valcecillas, IFIMAV, Santander 39008, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lopez-Larrea</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>1] Department of Immunology, Hospital Universitario Central de Asturias, Oviedo 33011, Spain [2] Fundación Renal 'Iñigo Álvarez de Toledo', Madrid 33011, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bowness</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gaffney</LastName><ForeName>Karl</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Norfolk and Norwich University Hospital, Norwich NR4 7UY, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gaston</LastName><ForeName>Hill</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Medicine, University of Cambridge, Addenbrookes Hospital, Cambridge CB2 0SP, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gladman</LastName><ForeName>Dafna D</ForeName><Initials>DD</Initials><AffiliationInfo><Affiliation>1] Division of Rheumatology, University of Toronto, Toronto, ON M4N 3M5, Canada [2] Toronto Western Research Institute, Toronto ON M4N 3M5, Canada [3] Psoriatic Arthritis Program, University Health Network, Toronto ON M4N 3M5, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rahman</LastName><ForeName>Proton</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Memorial University of Newfoundland, Newfoundland NL A1B 3X9, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maksymowych</LastName><ForeName>Walter P</ForeName><Initials>WP</Initials><AffiliationInfo><Affiliation>Department of Medicine, University of Alberta, Alberta T6G 2R7, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Crusius</LastName><ForeName>J Bart A</ForeName><Initials>JB</Initials><AffiliationInfo><Affiliation>Department of Medical Microbiology and Infection Control, Laboratory of Immunogenetics, VU University Medical Center, Amsterdam 1081 BT, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van der Horst-Bruinsma</LastName><ForeName>Irene E</ForeName><Initials>IE</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, VU University Medical Centre, Amsterdam 1081 BT, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Valle-Oñate</LastName><ForeName>Raphael</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Spondyloarthropaty Group-Division of Rheumatology, Hospital Militar Central/Universidad de La Sabana, Transversal 3 # 49-00, Bogotá, NA, Colombia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Romero-Sánchez</LastName><ForeName>Consuelo</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Spondyloarthropaty Group-Division of Rheumatology, Hospital Militar Central/Universidad de La Sabana, Transversal 3 # 49-00, Bogotá, NA, Colombia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hansen</LastName><ForeName>Inger Myrnes</ForeName><Initials>IM</Initials><AffiliationInfo><Affiliation>Helgelandssykehuset, 8613 Mo i Rana, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pimentel-Santos</LastName><ForeName>Fernando M</ForeName><Initials>FM</Initials><AffiliationInfo><Affiliation>Chronic Diseases Research Centre (CEDOC), Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa 1169-056, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Inman</LastName><ForeName>Robert D</ForeName><Initials>RD</Initials><AffiliationInfo><Affiliation>Division of Rheumatology, Toronto Western Hospital, University of Toronto, Toronto M5T2S8, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martin</LastName><ForeName>Javier</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones-Científicas, Granada 18100, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Breban</LastName><ForeName>Maxime</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>1] INSERM UMR 1173, Université de Versailles Saint Quentin en Yvelines, Laboratoire d'excellence Inflamex, Saint-Quentn-En-Yvelines 78180, France [2] Division of Rheumatology, Hôpital Ambroise Paré, AP-HP, and Université de Versailles Saint Quentin en Yvelines, Boulogne-Billancourt 92100, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wordsworth</LastName><ForeName>Bryan Paul</ForeName><Initials>BP</Initials><AffiliationInfo><Affiliation>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reveille</LastName><ForeName>John D</ForeName><Initials>JD</Initials><AffiliationInfo><Affiliation>Department of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Evans</LastName><ForeName>David M</ForeName><Initials>DM</Initials><AffiliationInfo><Affiliation>1] University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102, Australia [2] MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK [3] School of Social and Community Medicine, University of Bristol, Bristol, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Bakker</LastName><ForeName>Paul I W</ForeName><Initials>PI</Initials><AffiliationInfo><Affiliation>1] Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht 3584, The Netherlands [2] Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brown</LastName><ForeName>Matthew A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>084767</GrantID><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>19536</GrantID><Agency>Arthritis Research UK</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>19356</GrantID><Agency>Arthritis Research UK</Agency><Country>United Kingdom</Country></Grant><Grant><Agency>Intramural NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>1U01AI09090-01</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>MC_UU_12013/4</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>R01 AR062886</GrantID><Acronym>AR</Acronym><Agency>NIAMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>1R01AR062886-1</GrantID><Acronym>AR</Acronym><Agency>NIAMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P01 AR052915</GrantID><Acronym>AR</Acronym><Agency>NIAMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>18797</GrantID><Agency>Arthritis Research UK</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D052060">Research Support, N.I.H., Intramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate 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MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008285" MajorTopicYN="N">Major Histocompatibility Complex</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015778" MajorTopicYN="N">Minor Histocompatibility Antigens</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020641" MajorTopicYN="N">Polymorphism, Single Nucleotide</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013167" MajorTopicYN="N">Spondylitis, Ankylosing</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">EMS62909</OtherID><OtherID Source="NLM">PMC4443427</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>02</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>04</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>5</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>5</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>4</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25994336</ArticleId><ArticleId IdType="pii">ncomms8146</ArticleId><ArticleId IdType="doi">10.1038/ncomms8146</ArticleId><ArticleId IdType="pmc">PMC4443427</ArticleId><ArticleId IdType="mid">EMS62909</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Arabie saoudite</li><li>Australie</li><li>Belgique</li><li>Canada</li><li>Colombie</li><li>Espagne</li><li>Finlande</li><li>France</li><li>Mexique</li><li>Norvège</li><li>Nouvelle-Zélande</li><li>Pays-Bas</li><li>Portugal</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Communauté de Madrid</li><li>Ontario</li><li>Utrecht (province)</li><li>Île-de-France</li><li>Østlandet</li></region><settlement><li>Cambridge</li><li>Madrid</li><li>Oslo</li><li>Toronto</li><li>Utrecht</li><li>Versailles</li></settlement><orgName><li>Université de Cambridge</li><li>Université de Toronto</li><li>Université de Versailles-Saint-Quentin-en-Yvelines</li></orgName></list><tree><country name="Australie"><noRegion><name sortKey="Cortes, Adrian" sort="Cortes, Adrian" uniqKey="Cortes A" first="Adrian" last="Cortes">Adrian Cortes</name></noRegion><name sortKey="Bradbury, Linda A" sort="Bradbury, Linda A" uniqKey="Bradbury L" first="Linda A" last="Bradbury">Linda A. Bradbury</name><name sortKey="Brown, Matthew A" sort="Brown, Matthew A" uniqKey="Brown M" first="Matthew A" last="Brown">Matthew A. Brown</name><name sortKey="Leo, Paul J" sort="Leo, Paul J" uniqKey="Leo P" first="Paul J" last="Leo">Paul J. Leo</name><name sortKey="Nossent, Johannes" sort="Nossent, Johannes" uniqKey="Nossent J" first="Johannes" last="Nossent">Johannes Nossent</name><name sortKey="Robinson, Philip C" sort="Robinson, Philip C" uniqKey="Robinson P" first="Philip C" last="Robinson">Philip C. Robinson</name></country><country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Pulit, Sara L" sort="Pulit, Sara L" uniqKey="Pulit S" first="Sara L" last="Pulit">Sara L. Pulit</name></region><name sortKey="Crusius, J Bart A" sort="Crusius, J Bart A" uniqKey="Crusius J" first="J Bart A" last="Crusius">J Bart A. Crusius</name><name sortKey="De Bakker, Paul I W" sort="De Bakker, Paul I W" uniqKey="De Bakker P" first="Paul I W" last="De Bakker">Paul I W. De Bakker</name><name sortKey="Van Der Horst Bruinsma, Irene E" sort="Van Der Horst Bruinsma, Irene E" uniqKey="Van Der Horst Bruinsma I" first="Irene E" last="Van Der Horst-Bruinsma">Irene E. Van Der Horst-Bruinsma</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Pointon, Jenny J" sort="Pointon, Jenny J" uniqKey="Pointon J" first="Jenny J" last="Pointon">Jenny J. Pointon</name></noRegion><name sortKey="Appleton, Louise" sort="Appleton, Louise" uniqKey="Appleton L" first="Louise" last="Appleton">Louise Appleton</name><name sortKey="Bowness, Paul" sort="Bowness, Paul" uniqKey="Bowness P" first="Paul" last="Bowness">Paul Bowness</name><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M" last="Evans">David M. Evans</name><name sortKey="Farrah, Claire" sort="Farrah, Claire" uniqKey="Farrah C" first="Claire" last="Farrah">Claire Farrah</name><name sortKey="Gaffney, Karl" sort="Gaffney, Karl" uniqKey="Gaffney K" first="Karl" last="Gaffney">Karl Gaffney</name><name sortKey="Gaston, Hill" sort="Gaston, Hill" uniqKey="Gaston H" first="Hill" last="Gaston">Hill Gaston</name><name sortKey="Lau, Jonathan" sort="Lau, Jonathan" uniqKey="Lau J" first="Jonathan" last="Lau">Jonathan Lau</name><name sortKey="Wordsworth, Bryan Paul" sort="Wordsworth, Bryan Paul" uniqKey="Wordsworth B" first="Bryan Paul" last="Wordsworth">Bryan Paul Wordsworth</name></country><country name="États-Unis"><noRegion><name sortKey="Weisman, Michael H" sort="Weisman, Michael H" uniqKey="Weisman M" first="Michael H" last="Weisman">Michael H. Weisman</name></noRegion><name sortKey="Gensler, Lianne S" sort="Gensler, Lianne S" uniqKey="Gensler L" first="Lianne S" last="Gensler">Lianne S. Gensler</name><name sortKey="Reveille, John D" sort="Reveille, John D" uniqKey="Reveille J" first="John D" last="Reveille">John D. Reveille</name><name sortKey="Ward, Michael" sort="Ward, Michael" uniqKey="Ward M" first="Michael" last="Ward">Michael Ward</name><name sortKey="Zhou, Xiaodong" sort="Zhou, Xiaodong" uniqKey="Zhou X" first="Xiaodong" last="Zhou">Xiaodong Zhou</name></country><country name="France"><region name="Île-de-France"><name sortKey="Garchon, Henri Jean" sort="Garchon, Henri Jean" uniqKey="Garchon H" first="Henri-Jean" last="Garchon">Henri-Jean Garchon</name></region><name sortKey="Breban, Maxime" sort="Breban, Maxime" uniqKey="Breban M" first="Maxime" last="Breban">Maxime Breban</name><name sortKey="Chiocchia, Gilles" sort="Chiocchia, Gilles" uniqKey="Chiocchia G" first="Gilles" last="Chiocchia">Gilles Chiocchia</name></country><country name="Norvège"><region name="Østlandet"><name sortKey="Lie, Benedicte A" sort="Lie, Benedicte A" uniqKey="Lie B" first="Benedicte A" last="Lie">Benedicte A. Lie</name></region><name sortKey="F Rre, Ystein" sort="F Rre, Ystein" uniqKey="F Rre " first=" Ystein" last="F Rre"> Ystein F Rre</name><name sortKey="Hansen, Inger Myrnes" sort="Hansen, Inger Myrnes" uniqKey="Hansen I" first="Inger Myrnes" last="Hansen">Inger Myrnes Hansen</name></country><country name="Arabie saoudite"><noRegion><name sortKey="Tuomilehto, Jaakko" sort="Tuomilehto, Jaakko" uniqKey="Tuomilehto J" first="Jaakko" last="Tuomilehto">Jaakko Tuomilehto</name></noRegion></country><country name="Finlande"><noRegion><name sortKey="Laiho, Kari" sort="Laiho, Kari" uniqKey="Laiho K" first="Kari" last="Laiho">Kari Laiho</name></noRegion></country><country name="Belgique"><noRegion><name sortKey="Elewaut, Dirk" sort="Elewaut, Dirk" uniqKey="Elewaut D" first="Dirk" last="Elewaut">Dirk Elewaut</name></noRegion></country><country name="Mexique"><noRegion><name sortKey="Burgos Vargas, Ruben" sort="Burgos Vargas, Ruben" uniqKey="Burgos Vargas R" first="Ruben" last="Burgos-Vargas">Ruben Burgos-Vargas</name></noRegion></country><country name="Nouvelle-Zélande"><noRegion><name sortKey="Stebbings, Simon" sort="Stebbings, Simon" uniqKey="Stebbings S" first="Simon" last="Stebbings">Simon Stebbings</name></noRegion></country><country name="Canada"><region name="Ontario"><name sortKey="Haroon, Nigil" sort="Haroon, Nigil" uniqKey="Haroon N" first="Nigil" last="Haroon">Nigil Haroon</name></region><name sortKey="Gladman, Dafna D" sort="Gladman, Dafna D" uniqKey="Gladman D" first="Dafna D" last="Gladman">Dafna D. Gladman</name><name sortKey="Inman, Robert D" sort="Inman, Robert D" uniqKey="Inman R" first="Robert D" last="Inman">Robert D. Inman</name><name sortKey="Maksymowych, Walter P" sort="Maksymowych, Walter P" uniqKey="Maksymowych W" first="Walter P" last="Maksymowych">Walter P. Maksymowych</name><name sortKey="Rahman, Proton" sort="Rahman, Proton" uniqKey="Rahman P" first="Proton" last="Rahman">Proton Rahman</name></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Mulero, Juan" sort="Mulero, Juan" uniqKey="Mulero J" first="Juan" last="Mulero">Juan Mulero</name></region><name sortKey="Blanco, Francisco J" sort="Blanco, Francisco J" uniqKey="Blanco F" first="Francisco J" last="Blanco">Francisco J. Blanco</name><name sortKey="Gonzalez Gay, Miguel A" sort="Gonzalez Gay, Miguel A" uniqKey="Gonzalez Gay M" first="Miguel A" last="Gonzalez-Gay">Miguel A. Gonzalez-Gay</name><name sortKey="Lopez Larrea, C" sort="Lopez Larrea, C" uniqKey="Lopez Larrea C" first="C" last="Lopez-Larrea">C. Lopez-Larrea</name><name sortKey="Martin, Javier" sort="Martin, Javier" uniqKey="Martin J" first="Javier" last="Martin">Javier Martin</name></country><country name="Colombie"><noRegion><name sortKey="Valle O Ate, Raphael" sort="Valle O Ate, Raphael" uniqKey="Valle O Ate R" first="Raphael" last="Valle-O Ate">Raphael Valle-O Ate</name></noRegion><name sortKey="Romero Sanchez, Consuelo" sort="Romero Sanchez, Consuelo" uniqKey="Romero Sanchez C" first="Consuelo" last="Romero-Sánchez">Consuelo Romero-Sánchez</name></country><country name="Portugal"><noRegion><name sortKey="Pimentel Santos, Fernando M" sort="Pimentel Santos, Fernando M" uniqKey="Pimentel Santos F" first="Fernando M" last="Pimentel-Santos">Fernando M. Pimentel-Santos</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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