Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1.
Identifieur interne : 002D51 ( PubMed/Corpus ); précédent : 002D50; suivant : 002D52Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1.
Auteurs : Adrian Cortes ; Sara L. Pulit ; Paul J. Leo ; Jenny J. Pointon ; Philip C. Robinson ; Michael H. Weisman ; Michael Ward ; Lianne S. Gensler ; Xiaodong Zhou ; Henri-Jean Garchon ; Gilles Chiocchia ; Johannes Nossent ; Benedicte A. Lie ; Ystein F Rre ; Jaakko Tuomilehto ; Kari Laiho ; Linda A. Bradbury ; Dirk Elewaut ; Ruben Burgos-Vargas ; Simon Stebbings ; Louise Appleton ; Claire Farrah ; Jonathan Lau ; Nigil Haroon ; Juan Mulero ; Francisco J. Blanco ; Miguel A. Gonzalez-Gay ; C. Lopez-Larrea ; Paul Bowness ; Karl Gaffney ; Hill Gaston ; Dafna D. Gladman ; Proton Rahman ; Walter P. Maksymowych ; J Bart A. Crusius ; Irene E. Van Der Horst-Bruinsma ; Raphael Valle-O Ate ; Consuelo Romero-Sánchez ; Inger Myrnes Hansen ; Fernando M. Pimentel-Santos ; Robert D. Inman ; Javier Martin ; Maxime Breban ; Bryan Paul Wordsworth ; John D. Reveille ; David M. Evans ; Paul I W. De Bakker ; Matthew A. BrownSource :
- Nature communications [ 2041-1723 ] ; 2015.
English descriptors
- KwdEn :
- Aminopeptidases (genetics), Case-Control Studies, Epistasis, Genetic, Genetic Predisposition to Disease, HLA-B27 Antigen (genetics), HLA-B40 Antigen (genetics), Humans, Major Histocompatibility Complex, Minor Histocompatibility Antigens, Polymorphism, Single Nucleotide, Spondylitis, Ankylosing (etiology).
- MESH :
Abstract
Ankylosing spondylitis (AS) is a common, highly heritable, inflammatory arthritis for which HLA-B*27 is the major genetic risk factor, although its role in the aetiology of AS remains elusive. To better understand the genetic basis of the MHC susceptibility loci, we genotyped 7,264 MHC SNPs in 22,647 AS cases and controls of European descent. We impute SNPs, classical HLA alleles and amino-acid residues within HLA proteins, and tested these for association to AS status. Here we show that in addition to effects due to HLA-B*27 alleles, several other HLA-B alleles also affect susceptibility. After controlling for the associated haplotypes in HLA-B, we observe independent associations with variants in the HLA-A, HLA-DPB1 and HLA-DRB1 loci. We also demonstrate that the ERAP1 SNP rs30187 association is not restricted only to carriers of HLA-B*27 but also found in HLA-B*40:01 carriers independently of HLA-B*27 genotype.
DOI: 10.1038/ncomms8146
PubMed: 25994336
Links to Exploration step
pubmed:25994336Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1.</title>
<author><name sortKey="Cortes, Adrian" sort="Cortes, Adrian" uniqKey="Cortes A" first="Adrian" last="Cortes">Adrian Cortes</name>
<affiliation><nlm:affiliation>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pulit, Sara L" sort="Pulit, Sara L" uniqKey="Pulit S" first="Sara L" last="Pulit">Sara L. Pulit</name>
<affiliation><nlm:affiliation>Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht 3584, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Leo, Paul J" sort="Leo, Paul J" uniqKey="Leo P" first="Paul J" last="Leo">Paul J. Leo</name>
<affiliation><nlm:affiliation>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pointon, Jenny J" sort="Pointon, Jenny J" uniqKey="Pointon J" first="Jenny J" last="Pointon">Jenny J. Pointon</name>
<affiliation><nlm:affiliation>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Robinson, Philip C" sort="Robinson, Philip C" uniqKey="Robinson P" first="Philip C" last="Robinson">Philip C. Robinson</name>
<affiliation><nlm:affiliation>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Weisman, Michael H" sort="Weisman, Michael H" uniqKey="Weisman M" first="Michael H" last="Weisman">Michael H. Weisman</name>
<affiliation><nlm:affiliation>Department of Medicine/Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ward, Michael" sort="Ward, Michael" uniqKey="Ward M" first="Michael" last="Ward">Michael Ward</name>
<affiliation><nlm:affiliation>Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892-1468, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gensler, Lianne S" sort="Gensler, Lianne S" uniqKey="Gensler L" first="Lianne S" last="Gensler">Lianne S. Gensler</name>
<affiliation><nlm:affiliation>Department of Medicine/Rheumatology, University of California, San Francisco, California 94143, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Zhou, Xiaodong" sort="Zhou, Xiaodong" uniqKey="Zhou X" first="Xiaodong" last="Zhou">Xiaodong Zhou</name>
<affiliation><nlm:affiliation>Department of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Garchon, Henri Jean" sort="Garchon, Henri Jean" uniqKey="Garchon H" first="Henri-Jean" last="Garchon">Henri-Jean Garchon</name>
<affiliation><nlm:affiliation>1] INSERM UMR 1173, Université de Versailles Saint Quentin en Yvelines, Laboratoire d'excellence Inflamex, Saint-Quentn-En-Yvelines 78180, France [2] Genetics Division, Hôpital Ambroise Paré, AP-HP, and Université de Versailles Saint Quentin en Yvelines, Boulogne-Billancourt 78180, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chiocchia, Gilles" sort="Chiocchia, Gilles" uniqKey="Chiocchia G" first="Gilles" last="Chiocchia">Gilles Chiocchia</name>
<affiliation><nlm:affiliation>INSERM UMR 1173, Université de Versailles Saint Quentin en Yvelines, Laboratoire d'excellence Inflamex, Saint-Quentn-En-Yvelines 78180, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Nossent, Johannes" sort="Nossent, Johannes" uniqKey="Nossent J" first="Johannes" last="Nossent">Johannes Nossent</name>
<affiliation><nlm:affiliation>1] School of Medicine, University of Western Australia, Perth, WA 6009, Australia [2] Department of Rheumatology, Sir Charles Gairdner Hospital, Perth, WA 6009, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lie, Benedicte A" sort="Lie, Benedicte A" uniqKey="Lie B" first="Benedicte A" last="Lie">Benedicte A. Lie</name>
<affiliation><nlm:affiliation>1] Department of Medical Genetics, University of Oslo and Oslo University Hospital, Oslo 0310, Norway [2] Department of Immunology, Oslo University Hospital, Oslo 0310, Norway.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="F Rre, Ystein" sort="F Rre, Ystein" uniqKey="F Rre " first=" Ystein" last="F Rre"> Ystein F Rre</name>
<affiliation><nlm:affiliation>Department of Rheumatology, Oslo University Hospital, and University of Oslo, Oslo 0310, Norway.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tuomilehto, Jaakko" sort="Tuomilehto, Jaakko" uniqKey="Tuomilehto J" first="Jaakko" last="Tuomilehto">Jaakko Tuomilehto</name>
<affiliation><nlm:affiliation>1] Department of Chronic Disease Prevention, National Institute for Health and Welfare, 00271 Helsinki, Finland [2] Centre for Vascular Prevention, Danube-University Krems, 3500 Krems, Austria [3] Diabetes Research Group, King Abdulaziz University, 21589 Jeddah, Saudi Arabia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Laiho, Kari" sort="Laiho, Kari" uniqKey="Laiho K" first="Kari" last="Laiho">Kari Laiho</name>
<affiliation><nlm:affiliation>Department of Medicine, Paijat-Hame Central Hospital, Lahti, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bradbury, Linda A" sort="Bradbury, Linda A" uniqKey="Bradbury L" first="Linda A" last="Bradbury">Linda A. Bradbury</name>
<affiliation><nlm:affiliation>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Elewaut, Dirk" sort="Elewaut, Dirk" uniqKey="Elewaut D" first="Dirk" last="Elewaut">Dirk Elewaut</name>
<affiliation><nlm:affiliation>1] Department of Rheumatology, Gent University Hospital, Gent 9052, Belgium [2] VIB Inflammation Research Center, Ghent University, Gent 9052, Belgium.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Burgos Vargas, Ruben" sort="Burgos Vargas, Ruben" uniqKey="Burgos Vargas R" first="Ruben" last="Burgos-Vargas">Ruben Burgos-Vargas</name>
<affiliation><nlm:affiliation>Department of Rheumatology, Hospital General de Mexico and Universidad Nacional Autonoma de Mexico, Mexico City 06726, Mexico.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Stebbings, Simon" sort="Stebbings, Simon" uniqKey="Stebbings S" first="Simon" last="Stebbings">Simon Stebbings</name>
<affiliation><nlm:affiliation>Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin 9016, New Zealand.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Appleton, Louise" sort="Appleton, Louise" uniqKey="Appleton L" first="Louise" last="Appleton">Louise Appleton</name>
<affiliation><nlm:affiliation>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Farrah, Claire" sort="Farrah, Claire" uniqKey="Farrah C" first="Claire" last="Farrah">Claire Farrah</name>
<affiliation><nlm:affiliation>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lau, Jonathan" sort="Lau, Jonathan" uniqKey="Lau J" first="Jonathan" last="Lau">Jonathan Lau</name>
<affiliation><nlm:affiliation>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Haroon, Nigil" sort="Haroon, Nigil" uniqKey="Haroon N" first="Nigil" last="Haroon">Nigil Haroon</name>
<affiliation><nlm:affiliation>Division of Rheumatology, Toronto Western Hospital, University of Toronto, Toronto M5T2S8, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mulero, Juan" sort="Mulero, Juan" uniqKey="Mulero J" first="Juan" last="Mulero">Juan Mulero</name>
<affiliation><nlm:affiliation>Department of Rheumatology, Hospital Puerta de Hierro, Madrid 28222, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Blanco, Francisco J" sort="Blanco, Francisco J" uniqKey="Blanco F" first="Francisco J" last="Blanco">Francisco J. Blanco</name>
<affiliation><nlm:affiliation>Department of Rheumatology, Complejo Hospitalario La Coruña, INIBIC, La Coruña 15006, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gonzalez Gay, Miguel A" sort="Gonzalez Gay, Miguel A" uniqKey="Gonzalez Gay M" first="Miguel A" last="Gonzalez-Gay">Miguel A. Gonzalez-Gay</name>
<affiliation><nlm:affiliation>Department of Rheumatology, Hospital Marques de Valcecillas, IFIMAV, Santander 39008, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lopez Larrea, C" sort="Lopez Larrea, C" uniqKey="Lopez Larrea C" first="C" last="Lopez-Larrea">C. Lopez-Larrea</name>
<affiliation><nlm:affiliation>1] Department of Immunology, Hospital Universitario Central de Asturias, Oviedo 33011, Spain [2] Fundación Renal 'Iñigo Álvarez de Toledo', Madrid 33011, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bowness, Paul" sort="Bowness, Paul" uniqKey="Bowness P" first="Paul" last="Bowness">Paul Bowness</name>
<affiliation><nlm:affiliation>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gaffney, Karl" sort="Gaffney, Karl" uniqKey="Gaffney K" first="Karl" last="Gaffney">Karl Gaffney</name>
<affiliation><nlm:affiliation>Department of Rheumatology, Norfolk and Norwich University Hospital, Norwich NR4 7UY, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gaston, Hill" sort="Gaston, Hill" uniqKey="Gaston H" first="Hill" last="Gaston">Hill Gaston</name>
<affiliation><nlm:affiliation>Department of Medicine, University of Cambridge, Addenbrookes Hospital, Cambridge CB2 0SP, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gladman, Dafna D" sort="Gladman, Dafna D" uniqKey="Gladman D" first="Dafna D" last="Gladman">Dafna D. Gladman</name>
<affiliation><nlm:affiliation>1] Division of Rheumatology, University of Toronto, Toronto, ON M4N 3M5, Canada [2] Toronto Western Research Institute, Toronto ON M4N 3M5, Canada [3] Psoriatic Arthritis Program, University Health Network, Toronto ON M4N 3M5, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rahman, Proton" sort="Rahman, Proton" uniqKey="Rahman P" first="Proton" last="Rahman">Proton Rahman</name>
<affiliation><nlm:affiliation>Memorial University of Newfoundland, Newfoundland NL A1B 3X9, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Maksymowych, Walter P" sort="Maksymowych, Walter P" uniqKey="Maksymowych W" first="Walter P" last="Maksymowych">Walter P. Maksymowych</name>
<affiliation><nlm:affiliation>Department of Medicine, University of Alberta, Alberta T6G 2R7, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Crusius, J Bart A" sort="Crusius, J Bart A" uniqKey="Crusius J" first="J Bart A" last="Crusius">J Bart A. Crusius</name>
<affiliation><nlm:affiliation>Department of Medical Microbiology and Infection Control, Laboratory of Immunogenetics, VU University Medical Center, Amsterdam 1081 BT, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Van Der Horst Bruinsma, Irene E" sort="Van Der Horst Bruinsma, Irene E" uniqKey="Van Der Horst Bruinsma I" first="Irene E" last="Van Der Horst-Bruinsma">Irene E. Van Der Horst-Bruinsma</name>
<affiliation><nlm:affiliation>Department of Rheumatology, VU University Medical Centre, Amsterdam 1081 BT, Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Valle O Ate, Raphael" sort="Valle O Ate, Raphael" uniqKey="Valle O Ate R" first="Raphael" last="Valle-O Ate">Raphael Valle-O Ate</name>
<affiliation><nlm:affiliation>Spondyloarthropaty Group-Division of Rheumatology, Hospital Militar Central/Universidad de La Sabana, Transversal 3 # 49-00, Bogotá, NA, Colombia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Romero Sanchez, Consuelo" sort="Romero Sanchez, Consuelo" uniqKey="Romero Sanchez C" first="Consuelo" last="Romero-Sánchez">Consuelo Romero-Sánchez</name>
<affiliation><nlm:affiliation>Spondyloarthropaty Group-Division of Rheumatology, Hospital Militar Central/Universidad de La Sabana, Transversal 3 # 49-00, Bogotá, NA, Colombia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hansen, Inger Myrnes" sort="Hansen, Inger Myrnes" uniqKey="Hansen I" first="Inger Myrnes" last="Hansen">Inger Myrnes Hansen</name>
<affiliation><nlm:affiliation>Helgelandssykehuset, 8613 Mo i Rana, Norway.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pimentel Santos, Fernando M" sort="Pimentel Santos, Fernando M" uniqKey="Pimentel Santos F" first="Fernando M" last="Pimentel-Santos">Fernando M. Pimentel-Santos</name>
<affiliation><nlm:affiliation>Chronic Diseases Research Centre (CEDOC), Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa 1169-056, Portugal.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Inman, Robert D" sort="Inman, Robert D" uniqKey="Inman R" first="Robert D" last="Inman">Robert D. Inman</name>
<affiliation><nlm:affiliation>Division of Rheumatology, Toronto Western Hospital, University of Toronto, Toronto M5T2S8, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Martin, Javier" sort="Martin, Javier" uniqKey="Martin J" first="Javier" last="Martin">Javier Martin</name>
<affiliation><nlm:affiliation>Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones-Científicas, Granada 18100, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Breban, Maxime" sort="Breban, Maxime" uniqKey="Breban M" first="Maxime" last="Breban">Maxime Breban</name>
<affiliation><nlm:affiliation>1] INSERM UMR 1173, Université de Versailles Saint Quentin en Yvelines, Laboratoire d'excellence Inflamex, Saint-Quentn-En-Yvelines 78180, France [2] Division of Rheumatology, Hôpital Ambroise Paré, AP-HP, and Université de Versailles Saint Quentin en Yvelines, Boulogne-Billancourt 92100, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wordsworth, Bryan Paul" sort="Wordsworth, Bryan Paul" uniqKey="Wordsworth B" first="Bryan Paul" last="Wordsworth">Bryan Paul Wordsworth</name>
<affiliation><nlm:affiliation>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Reveille, John D" sort="Reveille, John D" uniqKey="Reveille J" first="John D" last="Reveille">John D. Reveille</name>
<affiliation><nlm:affiliation>Department of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M" last="Evans">David M. Evans</name>
<affiliation><nlm:affiliation>1] University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102, Australia [2] MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK [3] School of Social and Community Medicine, University of Bristol, Bristol, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="De Bakker, Paul I W" sort="De Bakker, Paul I W" uniqKey="De Bakker P" first="Paul I W" last="De Bakker">Paul I W. De Bakker</name>
<affiliation><nlm:affiliation>1] Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht 3584, The Netherlands [2] Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Brown, Matthew A" sort="Brown, Matthew A" uniqKey="Brown M" first="Matthew A" last="Brown">Matthew A. Brown</name>
<affiliation><nlm:affiliation>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102, Australia.</nlm:affiliation>
</affiliation>
</author>
</titleStmt>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1.</title>
<author><name sortKey="Cortes, Adrian" sort="Cortes, Adrian" uniqKey="Cortes A" first="Adrian" last="Cortes">Adrian Cortes</name>
<affiliation><nlm:affiliation>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pulit, Sara L" sort="Pulit, Sara L" uniqKey="Pulit S" first="Sara L" last="Pulit">Sara L. Pulit</name>
<affiliation><nlm:affiliation>Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht 3584, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Leo, Paul J" sort="Leo, Paul J" uniqKey="Leo P" first="Paul J" last="Leo">Paul J. Leo</name>
<affiliation><nlm:affiliation>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pointon, Jenny J" sort="Pointon, Jenny J" uniqKey="Pointon J" first="Jenny J" last="Pointon">Jenny J. Pointon</name>
<affiliation><nlm:affiliation>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Robinson, Philip C" sort="Robinson, Philip C" uniqKey="Robinson P" first="Philip C" last="Robinson">Philip C. Robinson</name>
<affiliation><nlm:affiliation>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Weisman, Michael H" sort="Weisman, Michael H" uniqKey="Weisman M" first="Michael H" last="Weisman">Michael H. Weisman</name>
<affiliation><nlm:affiliation>Department of Medicine/Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ward, Michael" sort="Ward, Michael" uniqKey="Ward M" first="Michael" last="Ward">Michael Ward</name>
<affiliation><nlm:affiliation>Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892-1468, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gensler, Lianne S" sort="Gensler, Lianne S" uniqKey="Gensler L" first="Lianne S" last="Gensler">Lianne S. Gensler</name>
<affiliation><nlm:affiliation>Department of Medicine/Rheumatology, University of California, San Francisco, California 94143, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Zhou, Xiaodong" sort="Zhou, Xiaodong" uniqKey="Zhou X" first="Xiaodong" last="Zhou">Xiaodong Zhou</name>
<affiliation><nlm:affiliation>Department of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Garchon, Henri Jean" sort="Garchon, Henri Jean" uniqKey="Garchon H" first="Henri-Jean" last="Garchon">Henri-Jean Garchon</name>
<affiliation><nlm:affiliation>1] INSERM UMR 1173, Université de Versailles Saint Quentin en Yvelines, Laboratoire d'excellence Inflamex, Saint-Quentn-En-Yvelines 78180, France [2] Genetics Division, Hôpital Ambroise Paré, AP-HP, and Université de Versailles Saint Quentin en Yvelines, Boulogne-Billancourt 78180, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chiocchia, Gilles" sort="Chiocchia, Gilles" uniqKey="Chiocchia G" first="Gilles" last="Chiocchia">Gilles Chiocchia</name>
<affiliation><nlm:affiliation>INSERM UMR 1173, Université de Versailles Saint Quentin en Yvelines, Laboratoire d'excellence Inflamex, Saint-Quentn-En-Yvelines 78180, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Nossent, Johannes" sort="Nossent, Johannes" uniqKey="Nossent J" first="Johannes" last="Nossent">Johannes Nossent</name>
<affiliation><nlm:affiliation>1] School of Medicine, University of Western Australia, Perth, WA 6009, Australia [2] Department of Rheumatology, Sir Charles Gairdner Hospital, Perth, WA 6009, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lie, Benedicte A" sort="Lie, Benedicte A" uniqKey="Lie B" first="Benedicte A" last="Lie">Benedicte A. Lie</name>
<affiliation><nlm:affiliation>1] Department of Medical Genetics, University of Oslo and Oslo University Hospital, Oslo 0310, Norway [2] Department of Immunology, Oslo University Hospital, Oslo 0310, Norway.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="F Rre, Ystein" sort="F Rre, Ystein" uniqKey="F Rre " first=" Ystein" last="F Rre"> Ystein F Rre</name>
<affiliation><nlm:affiliation>Department of Rheumatology, Oslo University Hospital, and University of Oslo, Oslo 0310, Norway.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tuomilehto, Jaakko" sort="Tuomilehto, Jaakko" uniqKey="Tuomilehto J" first="Jaakko" last="Tuomilehto">Jaakko Tuomilehto</name>
<affiliation><nlm:affiliation>1] Department of Chronic Disease Prevention, National Institute for Health and Welfare, 00271 Helsinki, Finland [2] Centre for Vascular Prevention, Danube-University Krems, 3500 Krems, Austria [3] Diabetes Research Group, King Abdulaziz University, 21589 Jeddah, Saudi Arabia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Laiho, Kari" sort="Laiho, Kari" uniqKey="Laiho K" first="Kari" last="Laiho">Kari Laiho</name>
<affiliation><nlm:affiliation>Department of Medicine, Paijat-Hame Central Hospital, Lahti, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bradbury, Linda A" sort="Bradbury, Linda A" uniqKey="Bradbury L" first="Linda A" last="Bradbury">Linda A. Bradbury</name>
<affiliation><nlm:affiliation>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Elewaut, Dirk" sort="Elewaut, Dirk" uniqKey="Elewaut D" first="Dirk" last="Elewaut">Dirk Elewaut</name>
<affiliation><nlm:affiliation>1] Department of Rheumatology, Gent University Hospital, Gent 9052, Belgium [2] VIB Inflammation Research Center, Ghent University, Gent 9052, Belgium.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Burgos Vargas, Ruben" sort="Burgos Vargas, Ruben" uniqKey="Burgos Vargas R" first="Ruben" last="Burgos-Vargas">Ruben Burgos-Vargas</name>
<affiliation><nlm:affiliation>Department of Rheumatology, Hospital General de Mexico and Universidad Nacional Autonoma de Mexico, Mexico City 06726, Mexico.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Stebbings, Simon" sort="Stebbings, Simon" uniqKey="Stebbings S" first="Simon" last="Stebbings">Simon Stebbings</name>
<affiliation><nlm:affiliation>Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin 9016, New Zealand.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Appleton, Louise" sort="Appleton, Louise" uniqKey="Appleton L" first="Louise" last="Appleton">Louise Appleton</name>
<affiliation><nlm:affiliation>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Farrah, Claire" sort="Farrah, Claire" uniqKey="Farrah C" first="Claire" last="Farrah">Claire Farrah</name>
<affiliation><nlm:affiliation>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lau, Jonathan" sort="Lau, Jonathan" uniqKey="Lau J" first="Jonathan" last="Lau">Jonathan Lau</name>
<affiliation><nlm:affiliation>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Haroon, Nigil" sort="Haroon, Nigil" uniqKey="Haroon N" first="Nigil" last="Haroon">Nigil Haroon</name>
<affiliation><nlm:affiliation>Division of Rheumatology, Toronto Western Hospital, University of Toronto, Toronto M5T2S8, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mulero, Juan" sort="Mulero, Juan" uniqKey="Mulero J" first="Juan" last="Mulero">Juan Mulero</name>
<affiliation><nlm:affiliation>Department of Rheumatology, Hospital Puerta de Hierro, Madrid 28222, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Blanco, Francisco J" sort="Blanco, Francisco J" uniqKey="Blanco F" first="Francisco J" last="Blanco">Francisco J. Blanco</name>
<affiliation><nlm:affiliation>Department of Rheumatology, Complejo Hospitalario La Coruña, INIBIC, La Coruña 15006, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gonzalez Gay, Miguel A" sort="Gonzalez Gay, Miguel A" uniqKey="Gonzalez Gay M" first="Miguel A" last="Gonzalez-Gay">Miguel A. Gonzalez-Gay</name>
<affiliation><nlm:affiliation>Department of Rheumatology, Hospital Marques de Valcecillas, IFIMAV, Santander 39008, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lopez Larrea, C" sort="Lopez Larrea, C" uniqKey="Lopez Larrea C" first="C" last="Lopez-Larrea">C. Lopez-Larrea</name>
<affiliation><nlm:affiliation>1] Department of Immunology, Hospital Universitario Central de Asturias, Oviedo 33011, Spain [2] Fundación Renal 'Iñigo Álvarez de Toledo', Madrid 33011, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bowness, Paul" sort="Bowness, Paul" uniqKey="Bowness P" first="Paul" last="Bowness">Paul Bowness</name>
<affiliation><nlm:affiliation>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gaffney, Karl" sort="Gaffney, Karl" uniqKey="Gaffney K" first="Karl" last="Gaffney">Karl Gaffney</name>
<affiliation><nlm:affiliation>Department of Rheumatology, Norfolk and Norwich University Hospital, Norwich NR4 7UY, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gaston, Hill" sort="Gaston, Hill" uniqKey="Gaston H" first="Hill" last="Gaston">Hill Gaston</name>
<affiliation><nlm:affiliation>Department of Medicine, University of Cambridge, Addenbrookes Hospital, Cambridge CB2 0SP, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gladman, Dafna D" sort="Gladman, Dafna D" uniqKey="Gladman D" first="Dafna D" last="Gladman">Dafna D. Gladman</name>
<affiliation><nlm:affiliation>1] Division of Rheumatology, University of Toronto, Toronto, ON M4N 3M5, Canada [2] Toronto Western Research Institute, Toronto ON M4N 3M5, Canada [3] Psoriatic Arthritis Program, University Health Network, Toronto ON M4N 3M5, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rahman, Proton" sort="Rahman, Proton" uniqKey="Rahman P" first="Proton" last="Rahman">Proton Rahman</name>
<affiliation><nlm:affiliation>Memorial University of Newfoundland, Newfoundland NL A1B 3X9, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Maksymowych, Walter P" sort="Maksymowych, Walter P" uniqKey="Maksymowych W" first="Walter P" last="Maksymowych">Walter P. Maksymowych</name>
<affiliation><nlm:affiliation>Department of Medicine, University of Alberta, Alberta T6G 2R7, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Crusius, J Bart A" sort="Crusius, J Bart A" uniqKey="Crusius J" first="J Bart A" last="Crusius">J Bart A. Crusius</name>
<affiliation><nlm:affiliation>Department of Medical Microbiology and Infection Control, Laboratory of Immunogenetics, VU University Medical Center, Amsterdam 1081 BT, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Van Der Horst Bruinsma, Irene E" sort="Van Der Horst Bruinsma, Irene E" uniqKey="Van Der Horst Bruinsma I" first="Irene E" last="Van Der Horst-Bruinsma">Irene E. Van Der Horst-Bruinsma</name>
<affiliation><nlm:affiliation>Department of Rheumatology, VU University Medical Centre, Amsterdam 1081 BT, Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Valle O Ate, Raphael" sort="Valle O Ate, Raphael" uniqKey="Valle O Ate R" first="Raphael" last="Valle-O Ate">Raphael Valle-O Ate</name>
<affiliation><nlm:affiliation>Spondyloarthropaty Group-Division of Rheumatology, Hospital Militar Central/Universidad de La Sabana, Transversal 3 # 49-00, Bogotá, NA, Colombia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Romero Sanchez, Consuelo" sort="Romero Sanchez, Consuelo" uniqKey="Romero Sanchez C" first="Consuelo" last="Romero-Sánchez">Consuelo Romero-Sánchez</name>
<affiliation><nlm:affiliation>Spondyloarthropaty Group-Division of Rheumatology, Hospital Militar Central/Universidad de La Sabana, Transversal 3 # 49-00, Bogotá, NA, Colombia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hansen, Inger Myrnes" sort="Hansen, Inger Myrnes" uniqKey="Hansen I" first="Inger Myrnes" last="Hansen">Inger Myrnes Hansen</name>
<affiliation><nlm:affiliation>Helgelandssykehuset, 8613 Mo i Rana, Norway.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pimentel Santos, Fernando M" sort="Pimentel Santos, Fernando M" uniqKey="Pimentel Santos F" first="Fernando M" last="Pimentel-Santos">Fernando M. Pimentel-Santos</name>
<affiliation><nlm:affiliation>Chronic Diseases Research Centre (CEDOC), Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa 1169-056, Portugal.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Inman, Robert D" sort="Inman, Robert D" uniqKey="Inman R" first="Robert D" last="Inman">Robert D. Inman</name>
<affiliation><nlm:affiliation>Division of Rheumatology, Toronto Western Hospital, University of Toronto, Toronto M5T2S8, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Martin, Javier" sort="Martin, Javier" uniqKey="Martin J" first="Javier" last="Martin">Javier Martin</name>
<affiliation><nlm:affiliation>Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones-Científicas, Granada 18100, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Breban, Maxime" sort="Breban, Maxime" uniqKey="Breban M" first="Maxime" last="Breban">Maxime Breban</name>
<affiliation><nlm:affiliation>1] INSERM UMR 1173, Université de Versailles Saint Quentin en Yvelines, Laboratoire d'excellence Inflamex, Saint-Quentn-En-Yvelines 78180, France [2] Division of Rheumatology, Hôpital Ambroise Paré, AP-HP, and Université de Versailles Saint Quentin en Yvelines, Boulogne-Billancourt 92100, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wordsworth, Bryan Paul" sort="Wordsworth, Bryan Paul" uniqKey="Wordsworth B" first="Bryan Paul" last="Wordsworth">Bryan Paul Wordsworth</name>
<affiliation><nlm:affiliation>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Reveille, John D" sort="Reveille, John D" uniqKey="Reveille J" first="John D" last="Reveille">John D. Reveille</name>
<affiliation><nlm:affiliation>Department of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M" last="Evans">David M. Evans</name>
<affiliation><nlm:affiliation>1] University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102, Australia [2] MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK [3] School of Social and Community Medicine, University of Bristol, Bristol, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="De Bakker, Paul I W" sort="De Bakker, Paul I W" uniqKey="De Bakker P" first="Paul I W" last="De Bakker">Paul I W. De Bakker</name>
<affiliation><nlm:affiliation>1] Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht 3584, The Netherlands [2] Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Brown, Matthew A" sort="Brown, Matthew A" uniqKey="Brown M" first="Matthew A" last="Brown">Matthew A. Brown</name>
<affiliation><nlm:affiliation>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102, Australia.</nlm:affiliation>
</affiliation>
</author>
</analytic>
<series><title level="j">Nature communications</title>
<idno type="eISSN">2041-1723</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aminopeptidases (genetics)</term>
<term>Case-Control Studies</term>
<term>Epistasis, Genetic</term>
<term>Genetic Predisposition to Disease</term>
<term>HLA-B27 Antigen (genetics)</term>
<term>HLA-B40 Antigen (genetics)</term>
<term>Humans</term>
<term>Major Histocompatibility Complex</term>
<term>Minor Histocompatibility Antigens</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Spondylitis, Ankylosing (etiology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Aminopeptidases</term>
<term>HLA-B27 Antigen</term>
<term>HLA-B40 Antigen</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Spondylitis, Ankylosing</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Case-Control Studies</term>
<term>Epistasis, Genetic</term>
<term>Genetic Predisposition to Disease</term>
<term>Humans</term>
<term>Major Histocompatibility Complex</term>
<term>Minor Histocompatibility Antigens</term>
<term>Polymorphism, Single Nucleotide</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en">Ankylosing spondylitis (AS) is a common, highly heritable, inflammatory arthritis for which HLA-B*27 is the major genetic risk factor, although its role in the aetiology of AS remains elusive. To better understand the genetic basis of the MHC susceptibility loci, we genotyped 7,264 MHC SNPs in 22,647 AS cases and controls of European descent. We impute SNPs, classical HLA alleles and amino-acid residues within HLA proteins, and tested these for association to AS status. Here we show that in addition to effects due to HLA-B*27 alleles, several other HLA-B alleles also affect susceptibility. After controlling for the associated haplotypes in HLA-B, we observe independent associations with variants in the HLA-A, HLA-DPB1 and HLA-DRB1 loci. We also demonstrate that the ERAP1 SNP rs30187 association is not restricted only to carriers of HLA-B*27 but also found in HLA-B*40:01 carriers independently of HLA-B*27 genotype.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25994336</PMID>
<DateCreated><Year>2015</Year>
<Month>05</Month>
<Day>21</Day>
</DateCreated>
<DateCompleted><Year>2016</Year>
<Month>04</Month>
<Day>11</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>09</Month>
<Day>22</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2041-1723</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>6</Volume>
<PubDate><Year>2015</Year>
<Month>May</Month>
<Day>21</Day>
</PubDate>
</JournalIssue>
<Title>Nature communications</Title>
<ISOAbbreviation>Nat Commun</ISOAbbreviation>
</Journal>
<ArticleTitle>Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1.</ArticleTitle>
<Pagination><MedlinePgn>7146</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1038/ncomms8146</ELocationID>
<Abstract><AbstractText>Ankylosing spondylitis (AS) is a common, highly heritable, inflammatory arthritis for which HLA-B*27 is the major genetic risk factor, although its role in the aetiology of AS remains elusive. To better understand the genetic basis of the MHC susceptibility loci, we genotyped 7,264 MHC SNPs in 22,647 AS cases and controls of European descent. We impute SNPs, classical HLA alleles and amino-acid residues within HLA proteins, and tested these for association to AS status. Here we show that in addition to effects due to HLA-B*27 alleles, several other HLA-B alleles also affect susceptibility. After controlling for the associated haplotypes in HLA-B, we observe independent associations with variants in the HLA-A, HLA-DPB1 and HLA-DRB1 loci. We also demonstrate that the ERAP1 SNP rs30187 association is not restricted only to carriers of HLA-B*27 but also found in HLA-B*40:01 carriers independently of HLA-B*27 genotype.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cortes</LastName>
<ForeName>Adrian</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pulit</LastName>
<ForeName>Sara L</ForeName>
<Initials>SL</Initials>
<AffiliationInfo><Affiliation>Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht 3584, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Leo</LastName>
<ForeName>Paul J</ForeName>
<Initials>PJ</Initials>
<AffiliationInfo><Affiliation>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pointon</LastName>
<ForeName>Jenny J</ForeName>
<Initials>JJ</Initials>
<AffiliationInfo><Affiliation>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Robinson</LastName>
<ForeName>Philip C</ForeName>
<Initials>PC</Initials>
<AffiliationInfo><Affiliation>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Weisman</LastName>
<ForeName>Michael H</ForeName>
<Initials>MH</Initials>
<AffiliationInfo><Affiliation>Department of Medicine/Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ward</LastName>
<ForeName>Michael</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892-1468, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gensler</LastName>
<ForeName>Lianne S</ForeName>
<Initials>LS</Initials>
<AffiliationInfo><Affiliation>Department of Medicine/Rheumatology, University of California, San Francisco, California 94143, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhou</LastName>
<ForeName>Xiaodong</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Department of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Garchon</LastName>
<ForeName>Henri-Jean</ForeName>
<Initials>HJ</Initials>
<AffiliationInfo><Affiliation>1] INSERM UMR 1173, Université de Versailles Saint Quentin en Yvelines, Laboratoire d'excellence Inflamex, Saint-Quentn-En-Yvelines 78180, France [2] Genetics Division, Hôpital Ambroise Paré, AP-HP, and Université de Versailles Saint Quentin en Yvelines, Boulogne-Billancourt 78180, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chiocchia</LastName>
<ForeName>Gilles</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>INSERM UMR 1173, Université de Versailles Saint Quentin en Yvelines, Laboratoire d'excellence Inflamex, Saint-Quentn-En-Yvelines 78180, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nossent</LastName>
<ForeName>Johannes</ForeName>
<Initials>J</Initials>
<Identifier Source="ORCID">0000000228337997</Identifier>
<AffiliationInfo><Affiliation>1] School of Medicine, University of Western Australia, Perth, WA 6009, Australia [2] Department of Rheumatology, Sir Charles Gairdner Hospital, Perth, WA 6009, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lie</LastName>
<ForeName>Benedicte A</ForeName>
<Initials>BA</Initials>
<AffiliationInfo><Affiliation>1] Department of Medical Genetics, University of Oslo and Oslo University Hospital, Oslo 0310, Norway [2] Department of Immunology, Oslo University Hospital, Oslo 0310, Norway.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Førre</LastName>
<ForeName>Øystein</ForeName>
<Initials>Ø</Initials>
<AffiliationInfo><Affiliation>Department of Rheumatology, Oslo University Hospital, and University of Oslo, Oslo 0310, Norway.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tuomilehto</LastName>
<ForeName>Jaakko</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>1] Department of Chronic Disease Prevention, National Institute for Health and Welfare, 00271 Helsinki, Finland [2] Centre for Vascular Prevention, Danube-University Krems, 3500 Krems, Austria [3] Diabetes Research Group, King Abdulaziz University, 21589 Jeddah, Saudi Arabia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Laiho</LastName>
<ForeName>Kari</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Paijat-Hame Central Hospital, Lahti, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bradbury</LastName>
<ForeName>Linda A</ForeName>
<Initials>LA</Initials>
<AffiliationInfo><Affiliation>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane 4102, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Elewaut</LastName>
<ForeName>Dirk</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>1] Department of Rheumatology, Gent University Hospital, Gent 9052, Belgium [2] VIB Inflammation Research Center, Ghent University, Gent 9052, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Burgos-Vargas</LastName>
<ForeName>Ruben</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Rheumatology, Hospital General de Mexico and Universidad Nacional Autonoma de Mexico, Mexico City 06726, Mexico.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Stebbings</LastName>
<ForeName>Simon</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin 9016, New Zealand.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Appleton</LastName>
<ForeName>Louise</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Farrah</LastName>
<ForeName>Claire</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lau</LastName>
<ForeName>Jonathan</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>NIHR Oxford Musculoskeletal Biomedical Research Unit, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Haroon</LastName>
<ForeName>Nigil</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Division of Rheumatology, Toronto Western Hospital, University of Toronto, Toronto M5T2S8, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mulero</LastName>
<ForeName>Juan</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Rheumatology, Hospital Puerta de Hierro, Madrid 28222, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Blanco</LastName>
<ForeName>Francisco J</ForeName>
<Initials>FJ</Initials>
<AffiliationInfo><Affiliation>Department of Rheumatology, Complejo Hospitalario La Coruña, INIBIC, La Coruña 15006, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gonzalez-Gay</LastName>
<ForeName>Miguel A</ForeName>
<Initials>MA</Initials>
<AffiliationInfo><Affiliation>Department of Rheumatology, Hospital Marques de Valcecillas, IFIMAV, Santander 39008, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lopez-Larrea</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
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