Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.
Identifieur interne : 002801 ( PubMed/Checkpoint ); précédent : 002800; suivant : 002802Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.
Auteurs : Willemijn J. Jansen [Pays-Bas] ; Rik Ossenkoppele ; Dirk L. Knol [Pays-Bas] ; Betty M. Tijms [Pays-Bas] ; Philip Scheltens [Pays-Bas] ; Frans R J. Verhey [Pays-Bas] ; Pieter Jelle Visser ; Pauline Aalten [Pays-Bas] ; Dag Aarsland [Norvège] ; Daniel Alcolea [Espagne] ; Myriam Alexander [Royaume-Uni] ; Ina S. Almdahl [Norvège] ; Steven E. Arnold [États-Unis] ; Inês Baldeiras [Portugal] ; Henryk Barthel [Allemagne] ; Bart N M. Van Berckel [Pays-Bas] ; Kristen Bibeau [États-Unis] ; Kaj Blennow [Suède] ; David J. Brooks [Royaume-Uni] ; Mark A. Van Buchem [Pays-Bas] ; Vincent Camus [France] ; Enrica Cavedo ; Kewei Chen [États-Unis] ; Gael Chetelat [France] ; Ann D. Cohen [États-Unis] ; Alexander Drzezga [Allemagne] ; Sebastiaan Engelborghs [Belgique] ; Anne M. Fagan [États-Unis] ; Tormod Fladby [Norvège] ; Adam S. Fleisher [États-Unis] ; Wiesje M. Van Der Flier [Pays-Bas] ; Lisa Ford [États-Unis] ; Stefan Förster [Allemagne] ; Juan Fortea [Espagne] ; Nadia Foskett [Royaume-Uni] ; Kristian S. Frederiksen [Danemark] ; Yvonne Freund-Levi [Suède] ; Giovanni B. Frisoni [Suisse] ; Lutz Froelich [Allemagne] ; Tomasz Gabryelewicz [Pologne] ; Kiran Dip Gill [Inde] ; Olymbia Gkatzima [Grèce] ; Estrella G Mez-Tortosa [Espagne] ; Mark Forrest Gordon [États-Unis] ; Timo Grimmer [Allemagne] ; Harald Hampel ; Lucrezia Hausner [Allemagne] ; Sabine Hellwig [Allemagne] ; Sanna-Kaisa Herukka [Finlande] ; Helmut Hildebrandt [Allemagne] ; Lianna Ishihara [Royaume-Uni] ; Adrian Ivanoiu [Belgique] ; William J. Jagust [États-Unis] ; Peter Johannsen [Danemark] ; Ramesh Kandimalla [Géorgie (pays)] ; Elisabeth Kapaki [Grèce] ; Aleksandra Klimkowicz-Mrowiec [Pologne] ; William E. Klunk [États-Unis] ; Sebastian Köhler [Pays-Bas] ; Norman Koglin [Allemagne] ; Johannes Kornhuber [Allemagne] ; Milica G. Kramberger [Slovénie] ; Koen Van Laere [Belgique] ; Susan M. Landau [États-Unis] ; Dong Young Lee [Corée du Sud] ; Mony De Leon [États-Unis] ; Viviana Lisetti [Italie] ; Alberto Lle [Espagne] ; Karine Madsen [Danemark] ; Wolfgang Maier [Allemagne] ; Jan Marcusson [Suède] ; Niklas Mattsson [Suède] ; Alexandre De Mendonça [Portugal] ; Olga Meulenbroek [Pays-Bas] ; Philipp T. Meyer [Allemagne] ; Mark A. Mintun [États-Unis] ; Vincent Mok [République populaire de Chine] ; José Luis Molinuevo [Espagne] ; Hanne M. M Llerg Rd [Norvège] ; John C. Morris [États-Unis] ; Barbara Mroczko [Pologne] ; Stefan Van Der Mussele [Belgique] ; Duk L. Na [Corée du Sud] ; Andrew Newberg [États-Unis] ; Agneta Nordberg [Suède] ; Arto Nordlund [Suède] ; Gerald P. Novak [États-Unis] ; George P. Paraskevas [Grèce] ; Lucilla Parnetti [Italie] ; Gayan Perera [Royaume-Uni] ; Oliver Peters [Allemagne] ; Julius Popp [Suisse] ; Sudesh Prabhakar [Inde] ; Gil D. Rabinovici [États-Unis] ; Inez H G B. Ramakers [Pays-Bas] ; Lorena Rami [Espagne] ; Catarina Resende De Oliveira [Portugal] ; Juha O. Rinne [Finlande] ; Karen M. Rodrigue ; Eloy Rodríguez-Rodríguez [Espagne] ; Catherine M. Roe [États-Unis] ; Uros Rot [Slovénie] ; Christopher C. Rowe [Australie] ; Eckart Rüther [Allemagne] ; Osama Sabri [Allemagne] ; Páscual Sanchez-Juan [Espagne] ; Isabel Santana [Portugal] ; Marie Sarazin [France] ; Johannes Schröder [Allemagne] ; Christin Schütte [Allemagne] ; Sang W. Seo [Corée du Sud] ; Femke Soetewey [Belgique] ; Hilkka Soininen [Finlande] ; Luiza Spiru [Roumanie] ; Hanne Struyfs [Belgique] ; Charlotte E. Teunissen [Pays-Bas] ; Magda Tsolaki [Grèce] ; Rik Vandenberghe [Belgique] ; Marcel M. Verbeek [Pays-Bas] ; Victor L. Villemagne [Australie] ; Stephanie J B. Vos [Pays-Bas] ; Linda J C. Van Waalwijk Van Doorn [Pays-Bas] ; Gunhild Waldemar [Danemark] ; Anders Wallin [Suède] ; Sa K. Wallin [Suède] ; Jens Wiltfang [Allemagne] ; David A. Wolk [États-Unis] ; Marzena Zboch [Pologne] ; Henrik Zetterberg [Royaume-Uni]Source :
- JAMA [ 1538-3598 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Apolipoprotéine E4 (génétique), Dysfonctionnement cognitif (anatomopathologie), Démence (anatomopathologie), Encéphale (anatomopathologie), Facteurs de l'âge, Facteurs de risque, Femelle, Génotype, Humains, Liquide cérébrospinal (), Marqueurs biologiques (analyse), Mâle, Peptides bêta-amyloïdes (analyse), Prévalence, Sujet âgé, Sujet âgé de 80 ans ou plus, Tomographie par émission de positons.
- MESH :
- analyse : Marqueurs biologiques, Peptides bêta-amyloïdes.
- anatomopathologie : Dysfonctionnement cognitif, Démence, Encéphale.
- génétique : Apolipoprotéine E4.
- Adulte, Adulte d'âge moyen, Facteurs de l'âge, Facteurs de risque, Femelle, Génotype, Humains, Liquide cérébrospinal, Mâle, Prévalence, Sujet âgé, Sujet âgé de 80 ans ou plus, Tomographie par émission de positons.
English descriptors
- KwdEn :
- Adult, Age Factors, Aged, Aged, 80 and over, Amyloid beta-Peptides (analysis), Apolipoprotein E4 (genetics), Biomarkers (analysis), Brain (pathology), Cerebrospinal Fluid (chemistry), Cognitive Dysfunction (pathology), Dementia (pathology), Female, Genotype, Humans, Male, Middle Aged, Positron-Emission Tomography, Prevalence, Risk Factors.
- MESH :
- chemical , analysis : Amyloid beta-Peptides, Biomarkers.
- chemical , genetics : Apolipoprotein E4.
- chemistry : Cerebrospinal Fluid.
- pathology : Brain, Cognitive Dysfunction, Dementia.
- Adult, Age Factors, Aged, Aged, 80 and over, Female, Genotype, Humans, Male, Middle Aged, Positron-Emission Tomography, Prevalence, Risk Factors.
Abstract
Cerebral amyloid-β aggregation is an early pathological event in Alzheimer disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid pathology in persons without dementia are needed to understand the development of AD and to design prevention studies.
DOI: 10.1001/jama.2015.4668
PubMed: 25988462
Affiliations:
- Allemagne, Australie, Belgique, Corée du Sud, Danemark, Espagne, Finlande, France, Grèce, Géorgie (pays), Inde, Italie, Norvège, Pays-Bas, Pologne, Portugal, Roumanie, Royaume-Uni, République populaire de Chine, Slovénie, Suisse, Suède, États-Unis
- Angleterre, Arizona, Attique (région), Bade-Wurtemberg, Basse-Normandie, Basse-Saxe, Bavière, Berlin, Brême (Land), Californie, Canton de Vaud, Caroline du Nord, Catalogne, Centre-Val de Loire, Communauté de Madrid, Connecticut, District de Cologne, District de Fribourg-en-Brisgau, District de Haute-Bavière, District de Karlsruhe, District de Leipzig, District de Moyenne-Franconie, Finlande occidentale, Grand Londres, Gueldre, Hollande-Méridionale, Hollande-Septentrionale, Hovedstaden, Missouri (État), New Jersey, Pennsylvanie, Province d'Anvers, Rhénanie-du-Nord-Westphalie, Région Centre, Région Normandie, Région capitale de Séoul, Région de Bruxelles-Capitale, Région flamande, Saxe (Land), Svealand, Victoria (État), État de New York, Île-de-France
- Amsterdam, Anvers, Athènes, Barcelone, Berkeley (Californie), Berlin, Bonn, Bruxelles, Brême, Caen, Copenhague, Erlangen, Fribourg-en-Brisgau, Göttingen, Heidelberg, Lausanne, Leipzig, Leyde, Londres, Madrid, Mannheim, Melbourne, Munich, Nimègue, Paris, Philadelphie, San Diego, San Francisco, Sha Tin, Stockholm, Séoul, Tours, Turku
- Université chinoise de Hong Kong, Université d'Anvers, Université nationale de Séoul
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pubmed:25988462Le document en format XML
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<author><name sortKey="Cavedo, Enrica" sort="Cavedo, Enrica" uniqKey="Cavedo E" first="Enrica" last="Cavedo">Enrica Cavedo</name>
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<author><name sortKey="Chen, Kewei" sort="Chen, Kewei" uniqKey="Chen K" first="Kewei" last="Chen">Kewei Chen</name>
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<author><name sortKey="Chetelat, Gael" sort="Chetelat, Gael" uniqKey="Chetelat G" first="Gael" last="Chetelat">Gael Chetelat</name>
<affiliation wicri:level="3"><nlm:affiliation>Institut National de la Santé et de la Recherche Médicale (Inserm), U1077, Caen, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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<author><name sortKey="Cohen, Ann D" sort="Cohen, Ann D" uniqKey="Cohen A" first="Ann D" last="Cohen">Ann D. Cohen</name>
<affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, Pennsylvania.</nlm:affiliation>
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<author><name sortKey="Drzezga, Alexander" sort="Drzezga, Alexander" uniqKey="Drzezga A" first="Alexander" last="Drzezga">Alexander Drzezga</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Nuclear Medicine, University of Cologne, Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
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<wicri:noRegion>Cologne</wicri:noRegion>
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<author><name sortKey="Engelborghs, Sebastiaan" sort="Engelborghs, Sebastiaan" uniqKey="Engelborghs S" first="Sebastiaan" last="Engelborghs">Sebastiaan Engelborghs</name>
<affiliation wicri:level="4"><nlm:affiliation>Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp</wicri:regionArea>
<orgName type="university">Université d'Anvers</orgName>
<placeName><settlement type="city">Anvers</settlement>
<region>Région flamande</region>
<region type="district" nuts="2">Province d'Anvers</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fagan, Anne M" sort="Fagan, Anne M" uniqKey="Fagan A" first="Anne M" last="Fagan">Anne M. Fagan</name>
<affiliation wicri:level="2"><nlm:affiliation>Knight Alzheimer's Disease Research Center, Department of Neurology, Washington University School of Medicine, St Louis, Missouri.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Knight Alzheimer's Disease Research Center, Department of Neurology, Washington University School of Medicine, St Louis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Fladby, Tormod" sort="Fladby, Tormod" uniqKey="Fladby T" first="Tormod" last="Fladby">Tormod Fladby</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Akershus University Hospital, Lørenskog, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Neurology, Akershus University Hospital, Lørenskog</wicri:regionArea>
<wicri:noRegion>Lørenskog</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fleisher, Adam S" sort="Fleisher, Adam S" uniqKey="Fleisher A" first="Adam S" last="Fleisher">Adam S. Fleisher</name>
<affiliation wicri:level="3"><nlm:affiliation>Banner Alzheimer's Institute, Phoenix, Arizona27Eli Lilly, Indianapolis, Indiana28Department of Neurosciences, University of California, San Diego.</nlm:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">San Diego</settlement>
<region type="state">Californie</region>
</placeName>
<wicri:orgArea>Banner Alzheimer's Institute, Phoenix, Arizona27Eli Lilly, Indianapolis, Indiana28Department of Neurosciences, University of California</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Van Der Flier, Wiesje M" sort="Van Der Flier, Wiesje M" uniqKey="Van Der Flier W" first="Wiesje M" last="Van Der Flier">Wiesje M. Van Der Flier</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands6Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands6Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ford, Lisa" sort="Ford, Lisa" uniqKey="Ford L" first="Lisa" last="Ford">Lisa Ford</name>
<affiliation wicri:level="2"><nlm:affiliation>Janssen Research and Development, Titusville, New Jersey.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Janssen Research and Development, Titusville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Forster, Stefan" sort="Forster, Stefan" uniqKey="Forster S" first="Stefan" last="Förster">Stefan Förster</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Nuclear Medicine, Technischen Universitaet München, Munich, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Nuclear Medicine, Technischen Universitaet München, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fortea, Juan" sort="Fortea, Juan" uniqKey="Fortea J" first="Juan" last="Fortea">Juan Fortea</name>
<affiliation wicri:level="3"><nlm:affiliation>Neurology Department, Hospital de Sant Pau, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Neurology Department, Hospital de Sant Pau, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Foskett, Nadia" sort="Foskett, Nadia" uniqKey="Foskett N" first="Nadia" last="Foskett">Nadia Foskett</name>
<affiliation wicri:level="1"><nlm:affiliation>Roche Products, Welwyn Garden City, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Roche Products, Welwyn Garden City</wicri:regionArea>
<wicri:noRegion>Welwyn Garden City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Frederiksen, Kristian S" sort="Frederiksen, Kristian S" uniqKey="Frederiksen K" first="Kristian S" last="Frederiksen">Kristian S. Frederiksen</name>
<affiliation wicri:level="1"><nlm:affiliation>Danish Dementia Research Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Danish Dementia Research Center, Department of Neurology, Rigshospitalet, University of Copenhagen</wicri:regionArea>
<wicri:noRegion>University of Copenhagen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Freund Levi, Yvonne" sort="Freund Levi, Yvonne" uniqKey="Freund Levi Y" first="Yvonne" last="Freund-Levi">Yvonne Freund-Levi</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Geriatrics, Institution of NVS, Section of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Geriatrics, Institution of NVS, Section of Clinical Geriatrics, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Frisoni, Giovanni B" sort="Frisoni, Giovanni B" uniqKey="Frisoni G" first="Giovanni B" last="Frisoni">Giovanni B. Frisoni</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS San Giovanni di Dio Fatebenefratelli, Brescia, Italy88Memory Clinic and LANVIE-Laboratory of Neuroimaging of Aging, University Hospitals, and University of Geneva, Geneva, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS San Giovanni di Dio Fatebenefratelli, Brescia, Italy88Memory Clinic and LANVIE-Laboratory of Neuroimaging of Aging, University Hospitals, and University of Geneva, Geneva</wicri:regionArea>
<wicri:noRegion>Geneva</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Froelich, Lutz" sort="Froelich, Lutz" uniqKey="Froelich L" first="Lutz" last="Froelich">Lutz Froelich</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Mannheim</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gabryelewicz, Tomasz" sort="Gabryelewicz, Tomasz" uniqKey="Gabryelewicz T" first="Tomasz" last="Gabryelewicz">Tomasz Gabryelewicz</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurodegenerative Disorders, Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Neurodegenerative Disorders, Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw</wicri:regionArea>
<wicri:noRegion>Warsaw</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gill, Kiran Dip" sort="Gill, Kiran Dip" uniqKey="Gill K" first="Kiran Dip" last="Gill">Kiran Dip Gill</name>
<affiliation wicri:level="1"><nlm:affiliation>Postgraduate Institute of Medical Education and Research (PGIMER), Department of Biochemistry, Research Block-A, Chandigarh, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Postgraduate Institute of Medical Education and Research (PGIMER), Department of Biochemistry, Research Block-A, Chandigarh</wicri:regionArea>
<wicri:noRegion>Chandigarh</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gkatzima, Olymbia" sort="Gkatzima, Olymbia" uniqKey="Gkatzima O" first="Olymbia" last="Gkatzima">Olymbia Gkatzima</name>
<affiliation wicri:level="1"><nlm:affiliation>Third Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Third Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki</wicri:regionArea>
<wicri:noRegion>Thessaloniki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="G Mez Tortosa, Estrella" sort="G Mez Tortosa, Estrella" uniqKey="G Mez Tortosa E" first="Estrella" last="G Mez-Tortosa">Estrella G Mez-Tortosa</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Fundación Jiménez Díaz, Madrid, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Neurology, Fundación Jiménez Díaz, Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gordon, Mark Forrest" sort="Gordon, Mark Forrest" uniqKey="Gordon M" first="Mark Forrest" last="Gordon">Mark Forrest Gordon</name>
<affiliation wicri:level="2"><nlm:affiliation>Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Boehringer Ingelheim Pharmaceuticals, Ridgefield</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Grimmer, Timo" sort="Grimmer, Timo" uniqKey="Grimmer T" first="Timo" last="Grimmer">Timo Grimmer</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitaet München, Munich, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitaet München, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hampel, Harald" sort="Hampel, Harald" uniqKey="Hampel H" first="Harald" last="Hampel">Harald Hampel</name>
<affiliation><nlm:affiliation>AXA Research Fund and UPMC ChairSorbonne Universités, Université Pierre et Marie Curie, Paris 06, Institut de la Mémoire et de la Maladie d'Alzheimer and INSERM U1127, Institut du Cerveau et de la Moelle épinière (ICM), Département de Neurologie, Hôpital.</nlm:affiliation>
<wicri:noCountry code="subField">Hôpital</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Hausner, Lucrezia" sort="Hausner, Lucrezia" uniqKey="Hausner L" first="Lucrezia" last="Hausner">Lucrezia Hausner</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Mannheim</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hellwig, Sabine" sort="Hellwig, Sabine" uniqKey="Hellwig S" first="Sabine" last="Hellwig">Sabine Hellwig</name>
<affiliation wicri:level="3"><nlm:affiliation>Center of Geriatrics and Gerontology, University Hospital Freiburg, Freiburg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center of Geriatrics and Gerontology, University Hospital Freiburg, Freiburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Fribourg-en-Brisgau</region>
<settlement type="city">Fribourg-en-Brisgau</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Herukka, Sanna Kaisa" sort="Herukka, Sanna Kaisa" uniqKey="Herukka S" first="Sanna-Kaisa" last="Herukka">Sanna-Kaisa Herukka</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio</wicri:regionArea>
<wicri:noRegion>Kuopio</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hildebrandt, Helmut" sort="Hildebrandt, Helmut" uniqKey="Hildebrandt H" first="Helmut" last="Hildebrandt">Helmut Hildebrandt</name>
<affiliation wicri:level="3"><nlm:affiliation>Center for Neurology, Hospital of Bremen-Ost, Bremen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Neurology, Hospital of Bremen-Ost, Bremen</wicri:regionArea>
<placeName><region type="land" nuts="3">Brême (Land)</region>
<settlement type="city">Brême</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ishihara, Lianna" sort="Ishihara, Lianna" uniqKey="Ishihara L" first="Lianna" last="Ishihara">Lianna Ishihara</name>
<affiliation wicri:level="1"><nlm:affiliation>GlaxoSmithKline, Worldwide Epidemiology, Epidemiology, Genetic Epidemiology and Neurology, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>GlaxoSmithKline, Worldwide Epidemiology, Epidemiology, Genetic Epidemiology and Neurology</wicri:regionArea>
<wicri:noRegion>Genetic Epidemiology and Neurology</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ivanoiu, Adrian" sort="Ivanoiu, Adrian" uniqKey="Ivanoiu A" first="Adrian" last="Ivanoiu">Adrian Ivanoiu</name>
<affiliation wicri:level="3"><nlm:affiliation>Memory Clinic and Neurochemistry Laboratory, Saint Luc University Hospital, Institute of Neuroscience, Université catholique de Louvain, Brussels, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Memory Clinic and Neurochemistry Laboratory, Saint Luc University Hospital, Institute of Neuroscience, Université catholique de Louvain, Brussels</wicri:regionArea>
<placeName><settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jagust, William J" sort="Jagust, William J" uniqKey="Jagust W" first="William J" last="Jagust">William J. Jagust</name>
<affiliation wicri:level="3"><nlm:affiliation>Helen Wills Neuroscience Institute, University of California, Berkeley.</nlm:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">Berkeley (Californie)</settlement>
<region type="state">Californie</region>
</placeName>
<wicri:orgArea>Helen Wills Neuroscience Institute, University of California</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Johannsen, Peter" sort="Johannsen, Peter" uniqKey="Johannsen P" first="Peter" last="Johannsen">Peter Johannsen</name>
<affiliation wicri:level="3"><nlm:affiliation>Memory Clinic, Danish Dementia Research Center, Rigshospitalet, Copenhagen, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Memory Clinic, Danish Dementia Research Center, Rigshospitalet, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kandimalla, Ramesh" sort="Kandimalla, Ramesh" uniqKey="Kandimalla R" first="Ramesh" last="Kandimalla">Ramesh Kandimalla</name>
<affiliation wicri:level="1"><nlm:affiliation>Postgraduate Institute of Medical Education and Research (PGIMER), Department of Biochemistry, Research Block-A, Chandigarh, India46Radiation Oncology, Emory University, Atlanta, Georgia.</nlm:affiliation>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Postgraduate Institute of Medical Education and Research (PGIMER), Department of Biochemistry, Research Block-A, Chandigarh, India46Radiation Oncology, Emory University, Atlanta</wicri:regionArea>
<wicri:noRegion>Atlanta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kapaki, Elisabeth" sort="Kapaki, Elisabeth" uniqKey="Kapaki E" first="Elisabeth" last="Kapaki">Elisabeth Kapaki</name>
<affiliation wicri:level="3"><nlm:affiliation>First Department of Neurology, Neurochemistry Unit and Cognitive and Movement Disorders Clinic, National and Kapodistrian University of Athens, Eginition Hospital, Athens, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>First Department of Neurology, Neurochemistry Unit and Cognitive and Movement Disorders Clinic, National and Kapodistrian University of Athens, Eginition Hospital, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Klimkowicz Mrowiec, Aleksandra" sort="Klimkowicz Mrowiec, Aleksandra" uniqKey="Klimkowicz Mrowiec A" first="Aleksandra" last="Klimkowicz-Mrowiec">Aleksandra Klimkowicz-Mrowiec</name>
<affiliation wicri:level="1"><nlm:affiliation>Jagiellonian University College of Medicine, Krakow, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Jagiellonian University College of Medicine, Krakow</wicri:regionArea>
<wicri:noRegion>Krakow</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Klunk, William E" sort="Klunk, William E" uniqKey="Klunk W" first="William E" last="Klunk">William E. Klunk</name>
<affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, Pennsylvania.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kohler, Sebastian" sort="Kohler, Sebastian" uniqKey="Kohler S" first="Sebastian" last="Köhler">Sebastian Köhler</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht</wicri:regionArea>
<wicri:noRegion>Maastricht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Koglin, Norman" sort="Koglin, Norman" uniqKey="Koglin N" first="Norman" last="Koglin">Norman Koglin</name>
<affiliation wicri:level="3"><nlm:affiliation>Piramal Imaging, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Piramal Imaging, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kornhuber, Johannes" sort="Kornhuber, Johannes" uniqKey="Kornhuber J" first="Johannes" last="Kornhuber">Johannes Kornhuber</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry and Psychotherapy, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen</wicri:regionArea>
<placeName><settlement type="city">Erlangen</settlement>
<region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Moyenne-Franconie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kramberger, Milica G" sort="Kramberger, Milica G" uniqKey="Kramberger M" first="Milica G" last="Kramberger">Milica G. Kramberger</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Cognitive Impairments, University Medical Centre Ljubljana, Ljubljana, Slovenia.</nlm:affiliation>
<country xml:lang="fr">Slovénie</country>
<wicri:regionArea>Center for Cognitive Impairments, University Medical Centre Ljubljana, Ljubljana</wicri:regionArea>
<wicri:noRegion>Ljubljana</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Laere, Koen" sort="Van Laere, Koen" uniqKey="Van Laere K" first="Koen" last="Van Laere">Koen Van Laere</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Imaging and Pathology, Catholic University Leuven, Leuven, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Imaging and Pathology, Catholic University Leuven, Leuven</wicri:regionArea>
<wicri:noRegion>Leuven</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Landau, Susan M" sort="Landau, Susan M" uniqKey="Landau S" first="Susan M" last="Landau">Susan M. Landau</name>
<affiliation wicri:level="3"><nlm:affiliation>Helen Wills Neuroscience Institute, University of California, Berkeley.</nlm:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">Berkeley (Californie)</settlement>
<region type="state">Californie</region>
</placeName>
<wicri:orgArea>Helen Wills Neuroscience Institute, University of California</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Lee, Dong Young" sort="Lee, Dong Young" uniqKey="Lee D" first="Dong Young" last="Lee">Dong Young Lee</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Neuropsychiatry, Seoul National University, College of Medicine, Seoul, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Neuropsychiatry, Seoul National University, College of Medicine, Seoul</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
<settlement type="city">Séoul</settlement>
</placeName>
<orgName type="university">Université nationale de Séoul</orgName>
</affiliation>
</author>
<author><name sortKey="De Leon, Mony" sort="De Leon, Mony" uniqKey="De Leon M" first="Mony" last="De Leon">Mony De Leon</name>
<affiliation wicri:level="2"><nlm:affiliation>School of Medicine, Center for Brain Health, New York University, New York.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>School of Medicine, Center for Brain Health, New York University</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lisetti, Viviana" sort="Lisetti, Viviana" uniqKey="Lisetti V" first="Viviana" last="Lisetti">Viviana Lisetti</name>
<affiliation wicri:level="1"><nlm:affiliation>Section of Neurology, Center for Memory Disturbances, University of Perugia, Perugia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Section of Neurology, Center for Memory Disturbances, University of Perugia, Perugia</wicri:regionArea>
<wicri:noRegion>Perugia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lle, Alberto" sort="Lle, Alberto" uniqKey="Lle A" first="Alberto" last="Lle">Alberto Lle</name>
<affiliation wicri:level="3"><nlm:affiliation>Neurology Department, Hospital de Sant Pau, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Neurology Department, Hospital de Sant Pau, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Madsen, Karine" sort="Madsen, Karine" uniqKey="Madsen K" first="Karine" last="Madsen">Karine Madsen</name>
<affiliation wicri:level="3"><nlm:affiliation>Neurobiology Research Unit, Copenhagen University Hospital, Copenhagen, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Neurobiology Research Unit, Copenhagen University Hospital, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Maier, Wolfgang" sort="Maier, Wolfgang" uniqKey="Maier W" first="Wolfgang" last="Maier">Wolfgang Maier</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry and Psychotherapy, University of Bonn, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, University of Bonn, German Center for Neurodegenerative Diseases (DZNE), Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Marcusson, Jan" sort="Marcusson, Jan" uniqKey="Marcusson J" first="Jan" last="Marcusson">Jan Marcusson</name>
<affiliation wicri:level="1"><nlm:affiliation>Geriatric Medicine, Department of Clinical and Experimental Medicine, University of Linköping, Linköping, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Geriatric Medicine, Department of Clinical and Experimental Medicine, University of Linköping, Linköping</wicri:regionArea>
<wicri:noRegion>Linköping</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mattsson, Niklas" sort="Mattsson, Niklas" uniqKey="Mattsson N" first="Niklas" last="Mattsson">Niklas Mattsson</name>
<affiliation wicri:level="1"><nlm:affiliation>Clinical Memory Research Unit, Clinical Sciences Malmö, Lund University, Lund, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Clinical Memory Research Unit, Clinical Sciences Malmö, Lund University, Lund</wicri:regionArea>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="De Mendonca, Alexandre" sort="De Mendonca, Alexandre" uniqKey="De Mendonca A" first="Alexandre" last="De Mendonça">Alexandre De Mendonça</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Medicine and Faculty of Medicine, University of Lisbon, Portugal.</nlm:affiliation>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Institute of Molecular Medicine and Faculty of Medicine, University of Lisbon</wicri:regionArea>
<wicri:noRegion>University of Lisbon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Meulenbroek, Olga" sort="Meulenbroek, Olga" uniqKey="Meulenbroek O" first="Olga" last="Meulenbroek">Olga Meulenbroek</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Geriatric Medicine, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Geriatric Medicine, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen</wicri:regionArea>
<placeName><settlement type="city">Nimègue</settlement>
<region type="province" nuts="2">Gueldre</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Meyer, Philipp T" sort="Meyer, Philipp T" uniqKey="Meyer P" first="Philipp T" last="Meyer">Philipp T. Meyer</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Nuclear Medicine, University Hospital Freiburg, Freiburg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Nuclear Medicine, University Hospital Freiburg, Freiburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Fribourg-en-Brisgau</region>
<settlement type="city">Fribourg-en-Brisgau</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mintun, Mark A" sort="Mintun, Mark A" uniqKey="Mintun M" first="Mark A" last="Mintun">Mark A. Mintun</name>
<affiliation wicri:level="2"><nlm:affiliation>Avid Radiopharmaceuticals, Philadelphia, Pennsylvania.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Avid Radiopharmaceuticals, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mok, Vincent" sort="Mok, Vincent" uniqKey="Mok V" first="Vincent" last="Mok">Vincent Mok</name>
<affiliation wicri:level="4"><nlm:affiliation>Lui Che Woo Institute of Innovative Medicine, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Lui Che Woo Institute of Innovative Medicine, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Molinuevo, Jose Luis" sort="Molinuevo, Jose Luis" uniqKey="Molinuevo J" first="José Luis" last="Molinuevo">José Luis Molinuevo</name>
<affiliation wicri:level="3"><nlm:affiliation>Alzheimer's Disease and Other Cognitive Disorders Unit, IDIBAPS, Clinic University Hospital, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Alzheimer's Disease and Other Cognitive Disorders Unit, IDIBAPS, Clinic University Hospital, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="M Llerg Rd, Hanne M" sort="M Llerg Rd, Hanne M" uniqKey="M Llerg Rd H" first="Hanne M" last="M Llerg Rd">Hanne M. M Llerg Rd</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Akershus University Hospital, Lørenskog, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Neurology, Akershus University Hospital, Lørenskog</wicri:regionArea>
<wicri:noRegion>Lørenskog</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Morris, John C" sort="Morris, John C" uniqKey="Morris J" first="John C" last="Morris">John C. Morris</name>
<affiliation wicri:level="2"><nlm:affiliation>Knight Alzheimer's Disease Research Center, Department of Neurology, Washington University School of Medicine, St Louis, Missouri.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Knight Alzheimer's Disease Research Center, Department of Neurology, Washington University School of Medicine, St Louis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mroczko, Barbara" sort="Mroczko, Barbara" uniqKey="Mroczko B" first="Barbara" last="Mroczko">Barbara Mroczko</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurodegeneration Diagnostics, Leading National Research Centre in Bialystok (KNOW), Medical University of Bialystok, Bialystok, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Neurodegeneration Diagnostics, Leading National Research Centre in Bialystok (KNOW), Medical University of Bialystok, Bialystok</wicri:regionArea>
<wicri:noRegion>Bialystok</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Der Mussele, Stefan" sort="Van Der Mussele, Stefan" uniqKey="Van Der Mussele S" first="Stefan" last="Van Der Mussele">Stefan Van Der Mussele</name>
<affiliation wicri:level="4"><nlm:affiliation>Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp</wicri:regionArea>
<orgName type="university">Université d'Anvers</orgName>
<placeName><settlement type="city">Anvers</settlement>
<region>Région flamande</region>
<region type="district" nuts="2">Province d'Anvers</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Na, Duk L" sort="Na, Duk L" uniqKey="Na D" first="Duk L" last="Na">Duk L. Na</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Newberg, Andrew" sort="Newberg, Andrew" uniqKey="Newberg A" first="Andrew" last="Newberg">Andrew Newberg</name>
<affiliation wicri:level="2"><nlm:affiliation>Myrna Brind Center of Integrative Medicine, Thomas Jefferson University and Hospital, Philadelphia, Pennsylvania.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Myrna Brind Center of Integrative Medicine, Thomas Jefferson University and Hospital, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Nordberg, Agneta" sort="Nordberg, Agneta" uniqKey="Nordberg A" first="Agneta" last="Nordberg">Agneta Nordberg</name>
<affiliation wicri:level="3"><nlm:affiliation>Dept NVS, Center for Alzheimer, Translational Alzheimer Neurobiology, Karolinska Institutet, and Geriatric Medicine, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Dept NVS, Center for Alzheimer, Translational Alzheimer Neurobiology, Karolinska Institutet, and Geriatric Medicine, Karolinska University Hospital, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nordlund, Arto" sort="Nordlund, Arto" uniqKey="Nordlund A" first="Arto" last="Nordlund">Arto Nordlund</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal</wicri:regionArea>
<wicri:noRegion>Mölndal</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Novak, Gerald P" sort="Novak, Gerald P" uniqKey="Novak G" first="Gerald P" last="Novak">Gerald P. Novak</name>
<affiliation wicri:level="2"><nlm:affiliation>Janssen Research and Development, Titusville, New Jersey.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Janssen Research and Development, Titusville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Paraskevas, George P" sort="Paraskevas, George P" uniqKey="Paraskevas G" first="George P" last="Paraskevas">George P. Paraskevas</name>
<affiliation wicri:level="3"><nlm:affiliation>First Department of Neurology, Neurochemistry Unit and Cognitive and Movement Disorders Clinic, National and Kapodistrian University of Athens, Eginition Hospital, Athens, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>First Department of Neurology, Neurochemistry Unit and Cognitive and Movement Disorders Clinic, National and Kapodistrian University of Athens, Eginition Hospital, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Parnetti, Lucilla" sort="Parnetti, Lucilla" uniqKey="Parnetti L" first="Lucilla" last="Parnetti">Lucilla Parnetti</name>
<affiliation wicri:level="1"><nlm:affiliation>Section of Neurology, Center for Memory Disturbances, University of Perugia, Perugia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Section of Neurology, Center for Memory Disturbances, University of Perugia, Perugia</wicri:regionArea>
<wicri:noRegion>Perugia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Perera, Gayan" sort="Perera, Gayan" uniqKey="Perera G" first="Gayan" last="Perera">Gayan Perera</name>
<affiliation wicri:level="3"><nlm:affiliation>Roche Products, Welwyn Garden City, United Kingdom69Department of Psychological Medicine, Institute of Psychiatry, Kings College London, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Roche Products, Welwyn Garden City, United Kingdom69Department of Psychological Medicine, Institute of Psychiatry, Kings College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Peters, Oliver" sort="Peters, Oliver" uniqKey="Peters O" first="Oliver" last="Peters">Oliver Peters</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry and Psychotherapy, Charité Berlin, German Center for Neurodegenrative Diseases (DZNE), Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, Charité Berlin, German Center for Neurodegenrative Diseases (DZNE), Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Popp, Julius" sort="Popp, Julius" uniqKey="Popp J" first="Julius" last="Popp">Julius Popp</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry, Service of Old Age Psychiatry and Department of Clinical Neurosciences, Leenaards Memory Centre, University Hospital of Lausanne, Lausanne, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Psychiatry, Service of Old Age Psychiatry and Department of Clinical Neurosciences, Leenaards Memory Centre, University Hospital of Lausanne, Lausanne</wicri:regionArea>
<placeName><settlement type="city">Lausanne</settlement>
<region nuts="3" type="region">Canton de Vaud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Prabhakar, Sudesh" sort="Prabhakar, Sudesh" uniqKey="Prabhakar S" first="Sudesh" last="Prabhakar">Sudesh Prabhakar</name>
<affiliation wicri:level="1"><nlm:affiliation>Postgraduate Institute of Medical Education and Research (PGIMER), Department of Neurology, Nehru Hospital, Chandigarh, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Postgraduate Institute of Medical Education and Research (PGIMER), Department of Neurology, Nehru Hospital, Chandigarh</wicri:regionArea>
<wicri:noRegion>Chandigarh</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rabinovici, Gil D" sort="Rabinovici, Gil D" uniqKey="Rabinovici G" first="Gil D" last="Rabinovici">Gil D. Rabinovici</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Memory and Aging Center, University of California, San Francisco.</nlm:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">San Francisco</settlement>
<region type="state">Californie</region>
</placeName>
<wicri:orgArea>Department of Neurology, Memory and Aging Center, University of California</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Ramakers, Inez H G B" sort="Ramakers, Inez H G B" uniqKey="Ramakers I" first="Inez H G B" last="Ramakers">Inez H G B. Ramakers</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht</wicri:regionArea>
<wicri:noRegion>Maastricht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rami, Lorena" sort="Rami, Lorena" uniqKey="Rami L" first="Lorena" last="Rami">Lorena Rami</name>
<affiliation wicri:level="3"><nlm:affiliation>Alzheimer's Disease and Other Cognitive Disorders Unit, IDIBAPS, Clinic University Hospital, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Alzheimer's Disease and Other Cognitive Disorders Unit, IDIBAPS, Clinic University Hospital, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Resende De Oliveira, Catarina" sort="Resende De Oliveira, Catarina" uniqKey="Resende De Oliveira C" first="Catarina" last="Resende De Oliveira">Catarina Resende De Oliveira</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Neuroscience and Cell Biology, Faculty of Medicine, Hospital Center University of Coimbra, Portugal.</nlm:affiliation>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Center for Neuroscience and Cell Biology, Faculty of Medicine, Hospital Center University of Coimbra</wicri:regionArea>
<wicri:noRegion>Hospital Center University of Coimbra</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O" last="Rinne">Juha O. Rinne</name>
<affiliation wicri:level="3"><nlm:affiliation>Turku PET Centre and Division of Clinical Neurosciences Turku, University of Turku and Turku University Hospital, Turku, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Turku PET Centre and Division of Clinical Neurosciences Turku, University of Turku and Turku University Hospital, Turku</wicri:regionArea>
<placeName><settlement type="city">Turku</settlement>
<region type="région" nuts="2">Finlande occidentale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rodrigue, Karen M" sort="Rodrigue, Karen M" uniqKey="Rodrigue K" first="Karen M" last="Rodrigue">Karen M. Rodrigue</name>
<affiliation><nlm:affiliation>Center for Vital Longevity, University of Texas at Dallas.</nlm:affiliation>
<wicri:noCountry code="subField">University of Texas at Dallas</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Rodriguez Rodriguez, Eloy" sort="Rodriguez Rodriguez, Eloy" uniqKey="Rodriguez Rodriguez E" first="Eloy" last="Rodríguez-Rodríguez">Eloy Rodríguez-Rodríguez</name>
<affiliation wicri:level="1"><nlm:affiliation>Neurology Service, Universitary Hospital Marqués de Valdecilla, IDIVAL, Santander, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Neurology Service, Universitary Hospital Marqués de Valdecilla, IDIVAL, Santander</wicri:regionArea>
<wicri:noRegion>Santander</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Roe, Catherine M" sort="Roe, Catherine M" uniqKey="Roe C" first="Catherine M" last="Roe">Catherine M. Roe</name>
<affiliation wicri:level="2"><nlm:affiliation>Knight Alzheimer's Disease Research Center, Department of Neurology, Washington University School of Medicine, St Louis, Missouri.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Knight Alzheimer's Disease Research Center, Department of Neurology, Washington University School of Medicine, St Louis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Rot, Uros" sort="Rot, Uros" uniqKey="Rot U" first="Uros" last="Rot">Uros Rot</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Cognitive Impairments, University Medical Centre Ljubljana, Ljubljana, Slovenia.</nlm:affiliation>
<country xml:lang="fr">Slovénie</country>
<wicri:regionArea>Center for Cognitive Impairments, University Medical Centre Ljubljana, Ljubljana</wicri:regionArea>
<wicri:noRegion>Ljubljana</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rowe, Christopher C" sort="Rowe, Christopher C" uniqKey="Rowe C" first="Christopher C" last="Rowe">Christopher C. Rowe</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Nuclear Medicine and Centre for PET, Austin Health, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Nuclear Medicine and Centre for PET, Austin Health, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ruther, Eckart" sort="Ruther, Eckart" uniqKey="Ruther E" first="Eckart" last="Rüther">Eckart Rüther</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August University, Göttingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August University, Göttingen</wicri:regionArea>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Göttingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sabri, Osama" sort="Sabri, Osama" uniqKey="Sabri O" first="Osama" last="Sabri">Osama Sabri</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Nuclear Medicine, University of Leipzig, Leipzig</wicri:regionArea>
<placeName><region type="land" nuts="1">Saxe (Land)</region>
<region type="district" nuts="2">District de Leipzig</region>
<settlement type="city">Leipzig</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sanchez Juan, Pascual" sort="Sanchez Juan, Pascual" uniqKey="Sanchez Juan P" first="Páscual" last="Sanchez-Juan">Páscual Sanchez-Juan</name>
<affiliation wicri:level="1"><nlm:affiliation>Neurology Service, Universitary Hospital Marqués de Valdecilla, IDIVAL, Santander, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Neurology Service, Universitary Hospital Marqués de Valdecilla, IDIVAL, Santander</wicri:regionArea>
<wicri:noRegion>Santander</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Santana, Isabel" sort="Santana, Isabel" uniqKey="Santana I" first="Isabel" last="Santana">Isabel Santana</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Neuroscience and Cell Biology, Faculty of Medicine, Hospital Center University of Coimbra, Portugal.</nlm:affiliation>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Center for Neuroscience and Cell Biology, Faculty of Medicine, Hospital Center University of Coimbra</wicri:regionArea>
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</author>
<author><name sortKey="Sarazin, Marie" sort="Sarazin, Marie" uniqKey="Sarazin M" first="Marie" last="Sarazin">Marie Sarazin</name>
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<country xml:lang="fr">France</country>
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<author><name sortKey="Seo, Sang W" sort="Seo, Sang W" uniqKey="Seo S" first="Sang W" last="Seo">Sang W. Seo</name>
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<country xml:lang="fr">Corée du Sud</country>
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<author><name sortKey="Soetewey, Femke" sort="Soetewey, Femke" uniqKey="Soetewey F" first="Femke" last="Soetewey">Femke Soetewey</name>
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<author><name sortKey="Soininen, Hilkka" sort="Soininen, Hilkka" uniqKey="Soininen H" first="Hilkka" last="Soininen">Hilkka Soininen</name>
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<author><name sortKey="Spiru, Luiza" sort="Spiru, Luiza" uniqKey="Spiru L" first="Luiza" last="Spiru">Luiza Spiru</name>
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<author><name sortKey="Struyfs, Hanne" sort="Struyfs, Hanne" uniqKey="Struyfs H" first="Hanne" last="Struyfs">Hanne Struyfs</name>
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<author><name sortKey="Teunissen, Charlotte E" sort="Teunissen, Charlotte E" uniqKey="Teunissen C" first="Charlotte E" last="Teunissen">Charlotte E. Teunissen</name>
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<author><name sortKey="Tsolaki, Magda" sort="Tsolaki, Magda" uniqKey="Tsolaki M" first="Magda" last="Tsolaki">Magda Tsolaki</name>
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<author><name sortKey="Vandenberghe, Rik" sort="Vandenberghe, Rik" uniqKey="Vandenberghe R" first="Rik" last="Vandenberghe">Rik Vandenberghe</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory for Cognitive Neurology and Alzheimer Research Centre KU Leuven, Catholic University Leuven, Leuven, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
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<author><name sortKey="Verbeek, Marcel M" sort="Verbeek, Marcel M" uniqKey="Verbeek M" first="Marcel M" last="Verbeek">Marcel M. Verbeek</name>
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<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
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<author><name sortKey="Villemagne, Victor L" sort="Villemagne, Victor L" uniqKey="Villemagne V" first="Victor L" last="Villemagne">Victor L. Villemagne</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Nuclear Medicine and Centre for PET, Austin Health, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
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<author><name sortKey="Vos, Stephanie J B" sort="Vos, Stephanie J B" uniqKey="Vos S" first="Stephanie J B" last="Vos">Stephanie J B. Vos</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
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<author><name sortKey="Van Waalwijk Van Doorn, Linda J C" sort="Van Waalwijk Van Doorn, Linda J C" uniqKey="Van Waalwijk Van Doorn L" first="Linda J C" last="Van Waalwijk Van Doorn">Linda J C. Van Waalwijk Van Doorn</name>
<affiliation wicri:level="3"><nlm:affiliation>Departments of Neurology and Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
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<author><name sortKey="Waldemar, Gunhild" sort="Waldemar, Gunhild" uniqKey="Waldemar G" first="Gunhild" last="Waldemar">Gunhild Waldemar</name>
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<author><name sortKey="Wallin, Sa K" sort="Wallin, Sa K" uniqKey="Wallin " first=" Sa K" last="Wallin"> Sa K. Wallin</name>
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<country xml:lang="fr">Suède</country>
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<author><name sortKey="Wiltfang, Jens" sort="Wiltfang, Jens" uniqKey="Wiltfang J" first="Jens" last="Wiltfang">Jens Wiltfang</name>
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<author><name sortKey="Wolk, David A" sort="Wolk, David A" uniqKey="Wolk D" first="David A" last="Wolk">David A. Wolk</name>
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<country>États-Unis</country>
<placeName><settlement type="city">Philadelphie</settlement>
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</placeName>
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<author><name sortKey="Zboch, Marzena" sort="Zboch, Marzena" uniqKey="Zboch M" first="Marzena" last="Zboch">Marzena Zboch</name>
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<country xml:lang="fr">Pologne</country>
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<author><name sortKey="Zetterberg, Henrik" sort="Zetterberg, Henrik" uniqKey="Zetterberg H" first="Henrik" last="Zetterberg">Henrik Zetterberg</name>
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<country xml:lang="fr">Royaume-Uni</country>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.</title>
<author><name sortKey="Jansen, Willemijn J" sort="Jansen, Willemijn J" uniqKey="Jansen W" first="Willemijn J" last="Jansen">Willemijn J. Jansen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht</wicri:regionArea>
<wicri:noRegion>Maastricht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ossenkoppele, Rik" sort="Ossenkoppele, Rik" uniqKey="Ossenkoppele R" first="Rik" last="Ossenkoppele">Rik Ossenkoppele</name>
<affiliation><nlm:affiliation>Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands3Department of Radiology and Nuclear Medicine, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the.</nlm:affiliation>
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<author><name sortKey="Knol, Dirk L" sort="Knol, Dirk L" uniqKey="Knol D" first="Dirk L" last="Knol">Dirk L. Knol</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam</wicri:regionArea>
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<author><name sortKey="Tijms, Betty M" sort="Tijms, Betty M" uniqKey="Tijms B" first="Betty M" last="Tijms">Betty M. Tijms</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam</wicri:regionArea>
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<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam</wicri:regionArea>
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<author><name sortKey="Verhey, Frans R J" sort="Verhey, Frans R J" uniqKey="Verhey F" first="Frans R J" last="Verhey">Frans R J. Verhey</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht</wicri:regionArea>
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<author><name sortKey="Visser, Pieter Jelle" sort="Visser, Pieter Jelle" uniqKey="Visser P" first="Pieter Jelle" last="Visser">Pieter Jelle Visser</name>
<affiliation><nlm:affiliation>Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands2Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience.</nlm:affiliation>
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<author><name sortKey="Aalten, Pauline" sort="Aalten, Pauline" uniqKey="Aalten P" first="Pauline" last="Aalten">Pauline Aalten</name>
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<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name>
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<country xml:lang="fr">Norvège</country>
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<author><name sortKey="Alcolea, Daniel" sort="Alcolea, Daniel" uniqKey="Alcolea D" first="Daniel" last="Alcolea">Daniel Alcolea</name>
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<author><name sortKey="Alexander, Myriam" sort="Alexander, Myriam" uniqKey="Alexander M" first="Myriam" last="Alexander">Myriam Alexander</name>
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<author><name sortKey="Almdahl, Ina S" sort="Almdahl, Ina S" uniqKey="Almdahl I" first="Ina S" last="Almdahl">Ina S. Almdahl</name>
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<author><name sortKey="Arnold, Steven E" sort="Arnold, Steven E" uniqKey="Arnold S" first="Steven E" last="Arnold">Steven E. Arnold</name>
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<placeName><settlement type="city">Philadelphie</settlement>
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</placeName>
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</affiliation>
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<author><name sortKey="Baldeiras, Ines" sort="Baldeiras, Ines" uniqKey="Baldeiras I" first="Inês" last="Baldeiras">Inês Baldeiras</name>
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<author><name sortKey="Barthel, Henryk" sort="Barthel, Henryk" uniqKey="Barthel H" first="Henryk" last="Barthel">Henryk Barthel</name>
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<country xml:lang="fr">Allemagne</country>
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<author><name sortKey="Van Berckel, Bart N M" sort="Van Berckel, Bart N M" uniqKey="Van Berckel B" first="Bart N M" last="Van Berckel">Bart N M. Van Berckel</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Radiology and Nuclear Medicine, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Radiology and Nuclear Medicine, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bibeau, Kristen" sort="Bibeau, Kristen" uniqKey="Bibeau K" first="Kristen" last="Bibeau">Kristen Bibeau</name>
<affiliation wicri:level="2"><nlm:affiliation>GlaxoSmithKline, Worldwide Epidemiology, Research Triangle Park, North Carolina.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>GlaxoSmithKline, Worldwide Epidemiology, Research Triangle Park</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Blennow, Kaj" sort="Blennow, Kaj" uniqKey="Blennow K" first="Kaj" last="Blennow">Kaj Blennow</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal</wicri:regionArea>
<wicri:noRegion>Mölndal</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J" last="Brooks">David J. Brooks</name>
<affiliation wicri:level="3"><nlm:affiliation>Division of Neuroscience, Medical Research Council Clinical Sciences Centre, Imperial College London, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Neuroscience, Medical Research Council Clinical Sciences Centre, Imperial College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Buchem, Mark A" sort="Van Buchem, Mark A" uniqKey="Van Buchem M" first="Mark A" last="Van Buchem">Mark A. Van Buchem</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Camus, Vincent" sort="Camus, Vincent" uniqKey="Camus V" first="Vincent" last="Camus">Vincent Camus</name>
<affiliation wicri:level="3"><nlm:affiliation>CHRU de Tours, CIC INSERM 1415, INSERM U930, and Université François Rabelais de Tours, Tours, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CHRU de Tours, CIC INSERM 1415, INSERM U930, and Université François Rabelais de Tours, Tours</wicri:regionArea>
<placeName><region type="region">Centre-Val de Loire</region>
<region type="old region">Région Centre</region>
<settlement type="city">Tours</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cavedo, Enrica" sort="Cavedo, Enrica" uniqKey="Cavedo E" first="Enrica" last="Cavedo">Enrica Cavedo</name>
<affiliation><nlm:affiliation>Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS San Giovanni di Dio Fatebenefratelli, Brescia, Italy20Sorbonne University, University Pierre et Marie Curie, Paris 06, Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A) and Institut.</nlm:affiliation>
<wicri:noCountry code="subField">Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A) and Institut</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Chen, Kewei" sort="Chen, Kewei" uniqKey="Chen K" first="Kewei" last="Chen">Kewei Chen</name>
<affiliation wicri:level="2"><nlm:affiliation>Banner Alzheimer's Institute, Phoenix, Arizona.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Arizona</region>
</placeName>
<wicri:cityArea>Banner Alzheimer's Institute, Phoenix</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Chetelat, Gael" sort="Chetelat, Gael" uniqKey="Chetelat G" first="Gael" last="Chetelat">Gael Chetelat</name>
<affiliation wicri:level="3"><nlm:affiliation>Institut National de la Santé et de la Recherche Médicale (Inserm), U1077, Caen, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut National de la Santé et de la Recherche Médicale (Inserm), U1077, Caen</wicri:regionArea>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cohen, Ann D" sort="Cohen, Ann D" uniqKey="Cohen A" first="Ann D" last="Cohen">Ann D. Cohen</name>
<affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, Pennsylvania.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Drzezga, Alexander" sort="Drzezga, Alexander" uniqKey="Drzezga A" first="Alexander" last="Drzezga">Alexander Drzezga</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Nuclear Medicine, University of Cologne, Cologne, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Nuclear Medicine, University of Cologne, Cologne</wicri:regionArea>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Engelborghs, Sebastiaan" sort="Engelborghs, Sebastiaan" uniqKey="Engelborghs S" first="Sebastiaan" last="Engelborghs">Sebastiaan Engelborghs</name>
<affiliation wicri:level="4"><nlm:affiliation>Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp</wicri:regionArea>
<orgName type="university">Université d'Anvers</orgName>
<placeName><settlement type="city">Anvers</settlement>
<region>Région flamande</region>
<region type="district" nuts="2">Province d'Anvers</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fagan, Anne M" sort="Fagan, Anne M" uniqKey="Fagan A" first="Anne M" last="Fagan">Anne M. Fagan</name>
<affiliation wicri:level="2"><nlm:affiliation>Knight Alzheimer's Disease Research Center, Department of Neurology, Washington University School of Medicine, St Louis, Missouri.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Knight Alzheimer's Disease Research Center, Department of Neurology, Washington University School of Medicine, St Louis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Fladby, Tormod" sort="Fladby, Tormod" uniqKey="Fladby T" first="Tormod" last="Fladby">Tormod Fladby</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Akershus University Hospital, Lørenskog, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Neurology, Akershus University Hospital, Lørenskog</wicri:regionArea>
<wicri:noRegion>Lørenskog</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fleisher, Adam S" sort="Fleisher, Adam S" uniqKey="Fleisher A" first="Adam S" last="Fleisher">Adam S. Fleisher</name>
<affiliation wicri:level="3"><nlm:affiliation>Banner Alzheimer's Institute, Phoenix, Arizona27Eli Lilly, Indianapolis, Indiana28Department of Neurosciences, University of California, San Diego.</nlm:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">San Diego</settlement>
<region type="state">Californie</region>
</placeName>
<wicri:orgArea>Banner Alzheimer's Institute, Phoenix, Arizona27Eli Lilly, Indianapolis, Indiana28Department of Neurosciences, University of California</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Van Der Flier, Wiesje M" sort="Van Der Flier, Wiesje M" uniqKey="Van Der Flier W" first="Wiesje M" last="Van Der Flier">Wiesje M. Van Der Flier</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands6Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands6Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ford, Lisa" sort="Ford, Lisa" uniqKey="Ford L" first="Lisa" last="Ford">Lisa Ford</name>
<affiliation wicri:level="2"><nlm:affiliation>Janssen Research and Development, Titusville, New Jersey.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Janssen Research and Development, Titusville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Forster, Stefan" sort="Forster, Stefan" uniqKey="Forster S" first="Stefan" last="Förster">Stefan Förster</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Nuclear Medicine, Technischen Universitaet München, Munich, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Nuclear Medicine, Technischen Universitaet München, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fortea, Juan" sort="Fortea, Juan" uniqKey="Fortea J" first="Juan" last="Fortea">Juan Fortea</name>
<affiliation wicri:level="3"><nlm:affiliation>Neurology Department, Hospital de Sant Pau, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Neurology Department, Hospital de Sant Pau, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Foskett, Nadia" sort="Foskett, Nadia" uniqKey="Foskett N" first="Nadia" last="Foskett">Nadia Foskett</name>
<affiliation wicri:level="1"><nlm:affiliation>Roche Products, Welwyn Garden City, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Roche Products, Welwyn Garden City</wicri:regionArea>
<wicri:noRegion>Welwyn Garden City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Frederiksen, Kristian S" sort="Frederiksen, Kristian S" uniqKey="Frederiksen K" first="Kristian S" last="Frederiksen">Kristian S. Frederiksen</name>
<affiliation wicri:level="1"><nlm:affiliation>Danish Dementia Research Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Danish Dementia Research Center, Department of Neurology, Rigshospitalet, University of Copenhagen</wicri:regionArea>
<wicri:noRegion>University of Copenhagen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Freund Levi, Yvonne" sort="Freund Levi, Yvonne" uniqKey="Freund Levi Y" first="Yvonne" last="Freund-Levi">Yvonne Freund-Levi</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Geriatrics, Institution of NVS, Section of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Geriatrics, Institution of NVS, Section of Clinical Geriatrics, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Frisoni, Giovanni B" sort="Frisoni, Giovanni B" uniqKey="Frisoni G" first="Giovanni B" last="Frisoni">Giovanni B. Frisoni</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS San Giovanni di Dio Fatebenefratelli, Brescia, Italy88Memory Clinic and LANVIE-Laboratory of Neuroimaging of Aging, University Hospitals, and University of Geneva, Geneva, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS San Giovanni di Dio Fatebenefratelli, Brescia, Italy88Memory Clinic and LANVIE-Laboratory of Neuroimaging of Aging, University Hospitals, and University of Geneva, Geneva</wicri:regionArea>
<wicri:noRegion>Geneva</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Froelich, Lutz" sort="Froelich, Lutz" uniqKey="Froelich L" first="Lutz" last="Froelich">Lutz Froelich</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Mannheim</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gabryelewicz, Tomasz" sort="Gabryelewicz, Tomasz" uniqKey="Gabryelewicz T" first="Tomasz" last="Gabryelewicz">Tomasz Gabryelewicz</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurodegenerative Disorders, Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Neurodegenerative Disorders, Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw</wicri:regionArea>
<wicri:noRegion>Warsaw</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gill, Kiran Dip" sort="Gill, Kiran Dip" uniqKey="Gill K" first="Kiran Dip" last="Gill">Kiran Dip Gill</name>
<affiliation wicri:level="1"><nlm:affiliation>Postgraduate Institute of Medical Education and Research (PGIMER), Department of Biochemistry, Research Block-A, Chandigarh, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Postgraduate Institute of Medical Education and Research (PGIMER), Department of Biochemistry, Research Block-A, Chandigarh</wicri:regionArea>
<wicri:noRegion>Chandigarh</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gkatzima, Olymbia" sort="Gkatzima, Olymbia" uniqKey="Gkatzima O" first="Olymbia" last="Gkatzima">Olymbia Gkatzima</name>
<affiliation wicri:level="1"><nlm:affiliation>Third Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Third Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki</wicri:regionArea>
<wicri:noRegion>Thessaloniki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="G Mez Tortosa, Estrella" sort="G Mez Tortosa, Estrella" uniqKey="G Mez Tortosa E" first="Estrella" last="G Mez-Tortosa">Estrella G Mez-Tortosa</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Fundación Jiménez Díaz, Madrid, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Neurology, Fundación Jiménez Díaz, Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gordon, Mark Forrest" sort="Gordon, Mark Forrest" uniqKey="Gordon M" first="Mark Forrest" last="Gordon">Mark Forrest Gordon</name>
<affiliation wicri:level="2"><nlm:affiliation>Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Connecticut</region>
</placeName>
<wicri:cityArea>Boehringer Ingelheim Pharmaceuticals, Ridgefield</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Grimmer, Timo" sort="Grimmer, Timo" uniqKey="Grimmer T" first="Timo" last="Grimmer">Timo Grimmer</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitaet München, Munich, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitaet München, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
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<author><name sortKey="Hampel, Harald" sort="Hampel, Harald" uniqKey="Hampel H" first="Harald" last="Hampel">Harald Hampel</name>
<affiliation><nlm:affiliation>AXA Research Fund and UPMC ChairSorbonne Universités, Université Pierre et Marie Curie, Paris 06, Institut de la Mémoire et de la Maladie d'Alzheimer and INSERM U1127, Institut du Cerveau et de la Moelle épinière (ICM), Département de Neurologie, Hôpital.</nlm:affiliation>
<wicri:noCountry code="subField">Hôpital</wicri:noCountry>
</affiliation>
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<author><name sortKey="Hausner, Lucrezia" sort="Hausner, Lucrezia" uniqKey="Hausner L" first="Lucrezia" last="Hausner">Lucrezia Hausner</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Mannheim</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hellwig, Sabine" sort="Hellwig, Sabine" uniqKey="Hellwig S" first="Sabine" last="Hellwig">Sabine Hellwig</name>
<affiliation wicri:level="3"><nlm:affiliation>Center of Geriatrics and Gerontology, University Hospital Freiburg, Freiburg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center of Geriatrics and Gerontology, University Hospital Freiburg, Freiburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Fribourg-en-Brisgau</region>
<settlement type="city">Fribourg-en-Brisgau</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Herukka, Sanna Kaisa" sort="Herukka, Sanna Kaisa" uniqKey="Herukka S" first="Sanna-Kaisa" last="Herukka">Sanna-Kaisa Herukka</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio</wicri:regionArea>
<wicri:noRegion>Kuopio</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hildebrandt, Helmut" sort="Hildebrandt, Helmut" uniqKey="Hildebrandt H" first="Helmut" last="Hildebrandt">Helmut Hildebrandt</name>
<affiliation wicri:level="3"><nlm:affiliation>Center for Neurology, Hospital of Bremen-Ost, Bremen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Neurology, Hospital of Bremen-Ost, Bremen</wicri:regionArea>
<placeName><region type="land" nuts="3">Brême (Land)</region>
<settlement type="city">Brême</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ishihara, Lianna" sort="Ishihara, Lianna" uniqKey="Ishihara L" first="Lianna" last="Ishihara">Lianna Ishihara</name>
<affiliation wicri:level="1"><nlm:affiliation>GlaxoSmithKline, Worldwide Epidemiology, Epidemiology, Genetic Epidemiology and Neurology, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>GlaxoSmithKline, Worldwide Epidemiology, Epidemiology, Genetic Epidemiology and Neurology</wicri:regionArea>
<wicri:noRegion>Genetic Epidemiology and Neurology</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ivanoiu, Adrian" sort="Ivanoiu, Adrian" uniqKey="Ivanoiu A" first="Adrian" last="Ivanoiu">Adrian Ivanoiu</name>
<affiliation wicri:level="3"><nlm:affiliation>Memory Clinic and Neurochemistry Laboratory, Saint Luc University Hospital, Institute of Neuroscience, Université catholique de Louvain, Brussels, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Memory Clinic and Neurochemistry Laboratory, Saint Luc University Hospital, Institute of Neuroscience, Université catholique de Louvain, Brussels</wicri:regionArea>
<placeName><settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jagust, William J" sort="Jagust, William J" uniqKey="Jagust W" first="William J" last="Jagust">William J. Jagust</name>
<affiliation wicri:level="3"><nlm:affiliation>Helen Wills Neuroscience Institute, University of California, Berkeley.</nlm:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">Berkeley (Californie)</settlement>
<region type="state">Californie</region>
</placeName>
<wicri:orgArea>Helen Wills Neuroscience Institute, University of California</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Johannsen, Peter" sort="Johannsen, Peter" uniqKey="Johannsen P" first="Peter" last="Johannsen">Peter Johannsen</name>
<affiliation wicri:level="3"><nlm:affiliation>Memory Clinic, Danish Dementia Research Center, Rigshospitalet, Copenhagen, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Memory Clinic, Danish Dementia Research Center, Rigshospitalet, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kandimalla, Ramesh" sort="Kandimalla, Ramesh" uniqKey="Kandimalla R" first="Ramesh" last="Kandimalla">Ramesh Kandimalla</name>
<affiliation wicri:level="1"><nlm:affiliation>Postgraduate Institute of Medical Education and Research (PGIMER), Department of Biochemistry, Research Block-A, Chandigarh, India46Radiation Oncology, Emory University, Atlanta, Georgia.</nlm:affiliation>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Postgraduate Institute of Medical Education and Research (PGIMER), Department of Biochemistry, Research Block-A, Chandigarh, India46Radiation Oncology, Emory University, Atlanta</wicri:regionArea>
<wicri:noRegion>Atlanta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kapaki, Elisabeth" sort="Kapaki, Elisabeth" uniqKey="Kapaki E" first="Elisabeth" last="Kapaki">Elisabeth Kapaki</name>
<affiliation wicri:level="3"><nlm:affiliation>First Department of Neurology, Neurochemistry Unit and Cognitive and Movement Disorders Clinic, National and Kapodistrian University of Athens, Eginition Hospital, Athens, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>First Department of Neurology, Neurochemistry Unit and Cognitive and Movement Disorders Clinic, National and Kapodistrian University of Athens, Eginition Hospital, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Klimkowicz Mrowiec, Aleksandra" sort="Klimkowicz Mrowiec, Aleksandra" uniqKey="Klimkowicz Mrowiec A" first="Aleksandra" last="Klimkowicz-Mrowiec">Aleksandra Klimkowicz-Mrowiec</name>
<affiliation wicri:level="1"><nlm:affiliation>Jagiellonian University College of Medicine, Krakow, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Jagiellonian University College of Medicine, Krakow</wicri:regionArea>
<wicri:noRegion>Krakow</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Klunk, William E" sort="Klunk, William E" uniqKey="Klunk W" first="William E" last="Klunk">William E. Klunk</name>
<affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, Pennsylvania.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kohler, Sebastian" sort="Kohler, Sebastian" uniqKey="Kohler S" first="Sebastian" last="Köhler">Sebastian Köhler</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht</wicri:regionArea>
<wicri:noRegion>Maastricht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Koglin, Norman" sort="Koglin, Norman" uniqKey="Koglin N" first="Norman" last="Koglin">Norman Koglin</name>
<affiliation wicri:level="3"><nlm:affiliation>Piramal Imaging, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Piramal Imaging, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kornhuber, Johannes" sort="Kornhuber, Johannes" uniqKey="Kornhuber J" first="Johannes" last="Kornhuber">Johannes Kornhuber</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry and Psychotherapy, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen</wicri:regionArea>
<placeName><settlement type="city">Erlangen</settlement>
<region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Moyenne-Franconie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kramberger, Milica G" sort="Kramberger, Milica G" uniqKey="Kramberger M" first="Milica G" last="Kramberger">Milica G. Kramberger</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Cognitive Impairments, University Medical Centre Ljubljana, Ljubljana, Slovenia.</nlm:affiliation>
<country xml:lang="fr">Slovénie</country>
<wicri:regionArea>Center for Cognitive Impairments, University Medical Centre Ljubljana, Ljubljana</wicri:regionArea>
<wicri:noRegion>Ljubljana</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Laere, Koen" sort="Van Laere, Koen" uniqKey="Van Laere K" first="Koen" last="Van Laere">Koen Van Laere</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Imaging and Pathology, Catholic University Leuven, Leuven, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Imaging and Pathology, Catholic University Leuven, Leuven</wicri:regionArea>
<wicri:noRegion>Leuven</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Landau, Susan M" sort="Landau, Susan M" uniqKey="Landau S" first="Susan M" last="Landau">Susan M. Landau</name>
<affiliation wicri:level="3"><nlm:affiliation>Helen Wills Neuroscience Institute, University of California, Berkeley.</nlm:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">Berkeley (Californie)</settlement>
<region type="state">Californie</region>
</placeName>
<wicri:orgArea>Helen Wills Neuroscience Institute, University of California</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Lee, Dong Young" sort="Lee, Dong Young" uniqKey="Lee D" first="Dong Young" last="Lee">Dong Young Lee</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Neuropsychiatry, Seoul National University, College of Medicine, Seoul, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Neuropsychiatry, Seoul National University, College of Medicine, Seoul</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
<settlement type="city">Séoul</settlement>
</placeName>
<orgName type="university">Université nationale de Séoul</orgName>
</affiliation>
</author>
<author><name sortKey="De Leon, Mony" sort="De Leon, Mony" uniqKey="De Leon M" first="Mony" last="De Leon">Mony De Leon</name>
<affiliation wicri:level="2"><nlm:affiliation>School of Medicine, Center for Brain Health, New York University, New York.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>School of Medicine, Center for Brain Health, New York University</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lisetti, Viviana" sort="Lisetti, Viviana" uniqKey="Lisetti V" first="Viviana" last="Lisetti">Viviana Lisetti</name>
<affiliation wicri:level="1"><nlm:affiliation>Section of Neurology, Center for Memory Disturbances, University of Perugia, Perugia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Section of Neurology, Center for Memory Disturbances, University of Perugia, Perugia</wicri:regionArea>
<wicri:noRegion>Perugia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lle, Alberto" sort="Lle, Alberto" uniqKey="Lle A" first="Alberto" last="Lle">Alberto Lle</name>
<affiliation wicri:level="3"><nlm:affiliation>Neurology Department, Hospital de Sant Pau, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Neurology Department, Hospital de Sant Pau, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Madsen, Karine" sort="Madsen, Karine" uniqKey="Madsen K" first="Karine" last="Madsen">Karine Madsen</name>
<affiliation wicri:level="3"><nlm:affiliation>Neurobiology Research Unit, Copenhagen University Hospital, Copenhagen, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Neurobiology Research Unit, Copenhagen University Hospital, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Maier, Wolfgang" sort="Maier, Wolfgang" uniqKey="Maier W" first="Wolfgang" last="Maier">Wolfgang Maier</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry and Psychotherapy, University of Bonn, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, University of Bonn, German Center for Neurodegenerative Diseases (DZNE), Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Marcusson, Jan" sort="Marcusson, Jan" uniqKey="Marcusson J" first="Jan" last="Marcusson">Jan Marcusson</name>
<affiliation wicri:level="1"><nlm:affiliation>Geriatric Medicine, Department of Clinical and Experimental Medicine, University of Linköping, Linköping, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Geriatric Medicine, Department of Clinical and Experimental Medicine, University of Linköping, Linköping</wicri:regionArea>
<wicri:noRegion>Linköping</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mattsson, Niklas" sort="Mattsson, Niklas" uniqKey="Mattsson N" first="Niklas" last="Mattsson">Niklas Mattsson</name>
<affiliation wicri:level="1"><nlm:affiliation>Clinical Memory Research Unit, Clinical Sciences Malmö, Lund University, Lund, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Clinical Memory Research Unit, Clinical Sciences Malmö, Lund University, Lund</wicri:regionArea>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="De Mendonca, Alexandre" sort="De Mendonca, Alexandre" uniqKey="De Mendonca A" first="Alexandre" last="De Mendonça">Alexandre De Mendonça</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Molecular Medicine and Faculty of Medicine, University of Lisbon, Portugal.</nlm:affiliation>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Institute of Molecular Medicine and Faculty of Medicine, University of Lisbon</wicri:regionArea>
<wicri:noRegion>University of Lisbon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Meulenbroek, Olga" sort="Meulenbroek, Olga" uniqKey="Meulenbroek O" first="Olga" last="Meulenbroek">Olga Meulenbroek</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Geriatric Medicine, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Geriatric Medicine, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen</wicri:regionArea>
<placeName><settlement type="city">Nimègue</settlement>
<region type="province" nuts="2">Gueldre</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Meyer, Philipp T" sort="Meyer, Philipp T" uniqKey="Meyer P" first="Philipp T" last="Meyer">Philipp T. Meyer</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Nuclear Medicine, University Hospital Freiburg, Freiburg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Nuclear Medicine, University Hospital Freiburg, Freiburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Fribourg-en-Brisgau</region>
<settlement type="city">Fribourg-en-Brisgau</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mintun, Mark A" sort="Mintun, Mark A" uniqKey="Mintun M" first="Mark A" last="Mintun">Mark A. Mintun</name>
<affiliation wicri:level="2"><nlm:affiliation>Avid Radiopharmaceuticals, Philadelphia, Pennsylvania.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Avid Radiopharmaceuticals, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mok, Vincent" sort="Mok, Vincent" uniqKey="Mok V" first="Vincent" last="Mok">Vincent Mok</name>
<affiliation wicri:level="4"><nlm:affiliation>Lui Che Woo Institute of Innovative Medicine, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Lui Che Woo Institute of Innovative Medicine, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName><settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Molinuevo, Jose Luis" sort="Molinuevo, Jose Luis" uniqKey="Molinuevo J" first="José Luis" last="Molinuevo">José Luis Molinuevo</name>
<affiliation wicri:level="3"><nlm:affiliation>Alzheimer's Disease and Other Cognitive Disorders Unit, IDIBAPS, Clinic University Hospital, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Alzheimer's Disease and Other Cognitive Disorders Unit, IDIBAPS, Clinic University Hospital, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="M Llerg Rd, Hanne M" sort="M Llerg Rd, Hanne M" uniqKey="M Llerg Rd H" first="Hanne M" last="M Llerg Rd">Hanne M. M Llerg Rd</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Akershus University Hospital, Lørenskog, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Neurology, Akershus University Hospital, Lørenskog</wicri:regionArea>
<wicri:noRegion>Lørenskog</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Morris, John C" sort="Morris, John C" uniqKey="Morris J" first="John C" last="Morris">John C. Morris</name>
<affiliation wicri:level="2"><nlm:affiliation>Knight Alzheimer's Disease Research Center, Department of Neurology, Washington University School of Medicine, St Louis, Missouri.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Knight Alzheimer's Disease Research Center, Department of Neurology, Washington University School of Medicine, St Louis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mroczko, Barbara" sort="Mroczko, Barbara" uniqKey="Mroczko B" first="Barbara" last="Mroczko">Barbara Mroczko</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurodegeneration Diagnostics, Leading National Research Centre in Bialystok (KNOW), Medical University of Bialystok, Bialystok, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Neurodegeneration Diagnostics, Leading National Research Centre in Bialystok (KNOW), Medical University of Bialystok, Bialystok</wicri:regionArea>
<wicri:noRegion>Bialystok</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Der Mussele, Stefan" sort="Van Der Mussele, Stefan" uniqKey="Van Der Mussele S" first="Stefan" last="Van Der Mussele">Stefan Van Der Mussele</name>
<affiliation wicri:level="4"><nlm:affiliation>Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp</wicri:regionArea>
<orgName type="university">Université d'Anvers</orgName>
<placeName><settlement type="city">Anvers</settlement>
<region>Région flamande</region>
<region type="district" nuts="2">Province d'Anvers</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Na, Duk L" sort="Na, Duk L" uniqKey="Na D" first="Duk L" last="Na">Duk L. Na</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Newberg, Andrew" sort="Newberg, Andrew" uniqKey="Newberg A" first="Andrew" last="Newberg">Andrew Newberg</name>
<affiliation wicri:level="2"><nlm:affiliation>Myrna Brind Center of Integrative Medicine, Thomas Jefferson University and Hospital, Philadelphia, Pennsylvania.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Myrna Brind Center of Integrative Medicine, Thomas Jefferson University and Hospital, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Nordberg, Agneta" sort="Nordberg, Agneta" uniqKey="Nordberg A" first="Agneta" last="Nordberg">Agneta Nordberg</name>
<affiliation wicri:level="3"><nlm:affiliation>Dept NVS, Center for Alzheimer, Translational Alzheimer Neurobiology, Karolinska Institutet, and Geriatric Medicine, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Dept NVS, Center for Alzheimer, Translational Alzheimer Neurobiology, Karolinska Institutet, and Geriatric Medicine, Karolinska University Hospital, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nordlund, Arto" sort="Nordlund, Arto" uniqKey="Nordlund A" first="Arto" last="Nordlund">Arto Nordlund</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal</wicri:regionArea>
<wicri:noRegion>Mölndal</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Novak, Gerald P" sort="Novak, Gerald P" uniqKey="Novak G" first="Gerald P" last="Novak">Gerald P. Novak</name>
<affiliation wicri:level="2"><nlm:affiliation>Janssen Research and Development, Titusville, New Jersey.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Janssen Research and Development, Titusville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Paraskevas, George P" sort="Paraskevas, George P" uniqKey="Paraskevas G" first="George P" last="Paraskevas">George P. Paraskevas</name>
<affiliation wicri:level="3"><nlm:affiliation>First Department of Neurology, Neurochemistry Unit and Cognitive and Movement Disorders Clinic, National and Kapodistrian University of Athens, Eginition Hospital, Athens, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>First Department of Neurology, Neurochemistry Unit and Cognitive and Movement Disorders Clinic, National and Kapodistrian University of Athens, Eginition Hospital, Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Parnetti, Lucilla" sort="Parnetti, Lucilla" uniqKey="Parnetti L" first="Lucilla" last="Parnetti">Lucilla Parnetti</name>
<affiliation wicri:level="1"><nlm:affiliation>Section of Neurology, Center for Memory Disturbances, University of Perugia, Perugia, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Section of Neurology, Center for Memory Disturbances, University of Perugia, Perugia</wicri:regionArea>
<wicri:noRegion>Perugia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Perera, Gayan" sort="Perera, Gayan" uniqKey="Perera G" first="Gayan" last="Perera">Gayan Perera</name>
<affiliation wicri:level="3"><nlm:affiliation>Roche Products, Welwyn Garden City, United Kingdom69Department of Psychological Medicine, Institute of Psychiatry, Kings College London, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Roche Products, Welwyn Garden City, United Kingdom69Department of Psychological Medicine, Institute of Psychiatry, Kings College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Peters, Oliver" sort="Peters, Oliver" uniqKey="Peters O" first="Oliver" last="Peters">Oliver Peters</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry and Psychotherapy, Charité Berlin, German Center for Neurodegenrative Diseases (DZNE), Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, Charité Berlin, German Center for Neurodegenrative Diseases (DZNE), Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Popp, Julius" sort="Popp, Julius" uniqKey="Popp J" first="Julius" last="Popp">Julius Popp</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry, Service of Old Age Psychiatry and Department of Clinical Neurosciences, Leenaards Memory Centre, University Hospital of Lausanne, Lausanne, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Psychiatry, Service of Old Age Psychiatry and Department of Clinical Neurosciences, Leenaards Memory Centre, University Hospital of Lausanne, Lausanne</wicri:regionArea>
<placeName><settlement type="city">Lausanne</settlement>
<region nuts="3" type="region">Canton de Vaud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Prabhakar, Sudesh" sort="Prabhakar, Sudesh" uniqKey="Prabhakar S" first="Sudesh" last="Prabhakar">Sudesh Prabhakar</name>
<affiliation wicri:level="1"><nlm:affiliation>Postgraduate Institute of Medical Education and Research (PGIMER), Department of Neurology, Nehru Hospital, Chandigarh, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Postgraduate Institute of Medical Education and Research (PGIMER), Department of Neurology, Nehru Hospital, Chandigarh</wicri:regionArea>
<wicri:noRegion>Chandigarh</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rabinovici, Gil D" sort="Rabinovici, Gil D" uniqKey="Rabinovici G" first="Gil D" last="Rabinovici">Gil D. Rabinovici</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Memory and Aging Center, University of California, San Francisco.</nlm:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">San Francisco</settlement>
<region type="state">Californie</region>
</placeName>
<wicri:orgArea>Department of Neurology, Memory and Aging Center, University of California</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Ramakers, Inez H G B" sort="Ramakers, Inez H G B" uniqKey="Ramakers I" first="Inez H G B" last="Ramakers">Inez H G B. Ramakers</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht</wicri:regionArea>
<wicri:noRegion>Maastricht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rami, Lorena" sort="Rami, Lorena" uniqKey="Rami L" first="Lorena" last="Rami">Lorena Rami</name>
<affiliation wicri:level="3"><nlm:affiliation>Alzheimer's Disease and Other Cognitive Disorders Unit, IDIBAPS, Clinic University Hospital, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Alzheimer's Disease and Other Cognitive Disorders Unit, IDIBAPS, Clinic University Hospital, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Resende De Oliveira, Catarina" sort="Resende De Oliveira, Catarina" uniqKey="Resende De Oliveira C" first="Catarina" last="Resende De Oliveira">Catarina Resende De Oliveira</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Neuroscience and Cell Biology, Faculty of Medicine, Hospital Center University of Coimbra, Portugal.</nlm:affiliation>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Center for Neuroscience and Cell Biology, Faculty of Medicine, Hospital Center University of Coimbra</wicri:regionArea>
<wicri:noRegion>Hospital Center University of Coimbra</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O" last="Rinne">Juha O. Rinne</name>
<affiliation wicri:level="3"><nlm:affiliation>Turku PET Centre and Division of Clinical Neurosciences Turku, University of Turku and Turku University Hospital, Turku, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Turku PET Centre and Division of Clinical Neurosciences Turku, University of Turku and Turku University Hospital, Turku</wicri:regionArea>
<placeName><settlement type="city">Turku</settlement>
<region type="région" nuts="2">Finlande occidentale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rodrigue, Karen M" sort="Rodrigue, Karen M" uniqKey="Rodrigue K" first="Karen M" last="Rodrigue">Karen M. Rodrigue</name>
<affiliation><nlm:affiliation>Center for Vital Longevity, University of Texas at Dallas.</nlm:affiliation>
<wicri:noCountry code="subField">University of Texas at Dallas</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Rodriguez Rodriguez, Eloy" sort="Rodriguez Rodriguez, Eloy" uniqKey="Rodriguez Rodriguez E" first="Eloy" last="Rodríguez-Rodríguez">Eloy Rodríguez-Rodríguez</name>
<affiliation wicri:level="1"><nlm:affiliation>Neurology Service, Universitary Hospital Marqués de Valdecilla, IDIVAL, Santander, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Neurology Service, Universitary Hospital Marqués de Valdecilla, IDIVAL, Santander</wicri:regionArea>
<wicri:noRegion>Santander</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Roe, Catherine M" sort="Roe, Catherine M" uniqKey="Roe C" first="Catherine M" last="Roe">Catherine M. Roe</name>
<affiliation wicri:level="2"><nlm:affiliation>Knight Alzheimer's Disease Research Center, Department of Neurology, Washington University School of Medicine, St Louis, Missouri.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
<wicri:cityArea>Knight Alzheimer's Disease Research Center, Department of Neurology, Washington University School of Medicine, St Louis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Rot, Uros" sort="Rot, Uros" uniqKey="Rot U" first="Uros" last="Rot">Uros Rot</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Cognitive Impairments, University Medical Centre Ljubljana, Ljubljana, Slovenia.</nlm:affiliation>
<country xml:lang="fr">Slovénie</country>
<wicri:regionArea>Center for Cognitive Impairments, University Medical Centre Ljubljana, Ljubljana</wicri:regionArea>
<wicri:noRegion>Ljubljana</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rowe, Christopher C" sort="Rowe, Christopher C" uniqKey="Rowe C" first="Christopher C" last="Rowe">Christopher C. Rowe</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Nuclear Medicine and Centre for PET, Austin Health, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Nuclear Medicine and Centre for PET, Austin Health, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ruther, Eckart" sort="Ruther, Eckart" uniqKey="Ruther E" first="Eckart" last="Rüther">Eckart Rüther</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August University, Göttingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August University, Göttingen</wicri:regionArea>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Göttingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sabri, Osama" sort="Sabri, Osama" uniqKey="Sabri O" first="Osama" last="Sabri">Osama Sabri</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Nuclear Medicine, University of Leipzig, Leipzig</wicri:regionArea>
<placeName><region type="land" nuts="1">Saxe (Land)</region>
<region type="district" nuts="2">District de Leipzig</region>
<settlement type="city">Leipzig</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sanchez Juan, Pascual" sort="Sanchez Juan, Pascual" uniqKey="Sanchez Juan P" first="Páscual" last="Sanchez-Juan">Páscual Sanchez-Juan</name>
<affiliation wicri:level="1"><nlm:affiliation>Neurology Service, Universitary Hospital Marqués de Valdecilla, IDIVAL, Santander, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Neurology Service, Universitary Hospital Marqués de Valdecilla, IDIVAL, Santander</wicri:regionArea>
<wicri:noRegion>Santander</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Santana, Isabel" sort="Santana, Isabel" uniqKey="Santana I" first="Isabel" last="Santana">Isabel Santana</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Neuroscience and Cell Biology, Faculty of Medicine, Hospital Center University of Coimbra, Portugal.</nlm:affiliation>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Center for Neuroscience and Cell Biology, Faculty of Medicine, Hospital Center University of Coimbra</wicri:regionArea>
<wicri:noRegion>Hospital Center University of Coimbra</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sarazin, Marie" sort="Sarazin, Marie" uniqKey="Sarazin M" first="Marie" last="Sarazin">Marie Sarazin</name>
<affiliation wicri:level="3"><nlm:affiliation>Neurologie de la Mémoire et du Langage, Centre Hospitalier Sainte-Anne, Université Paris 5, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Neurologie de la Mémoire et du Langage, Centre Hospitalier Sainte-Anne, Université Paris 5, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schroder, Johannes" sort="Schroder, Johannes" uniqKey="Schroder J" first="Johannes" last="Schröder">Johannes Schröder</name>
<affiliation wicri:level="3"><nlm:affiliation>Sektion Gerontopsychiatrie, Universität Heidelberg, Heidelberg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Sektion Gerontopsychiatrie, Universität Heidelberg, Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schutte, Christin" sort="Schutte, Christin" uniqKey="Schutte C" first="Christin" last="Schütte">Christin Schütte</name>
<affiliation wicri:level="3"><nlm:affiliation>Center for Neurology, Hospital of Bremen-Ost, Bremen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Neurology, Hospital of Bremen-Ost, Bremen</wicri:regionArea>
<placeName><region type="land" nuts="3">Brême (Land)</region>
<settlement type="city">Brême</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Seo, Sang W" sort="Seo, Sang W" uniqKey="Seo S" first="Sang W" last="Seo">Sang W. Seo</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Soetewey, Femke" sort="Soetewey, Femke" uniqKey="Soetewey F" first="Femke" last="Soetewey">Femke Soetewey</name>
<affiliation wicri:level="4"><nlm:affiliation>Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp</wicri:regionArea>
<orgName type="university">Université d'Anvers</orgName>
<placeName><settlement type="city">Anvers</settlement>
<region>Région flamande</region>
<region type="district" nuts="2">Province d'Anvers</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Soininen, Hilkka" sort="Soininen, Hilkka" uniqKey="Soininen H" first="Hilkka" last="Soininen">Hilkka Soininen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio</wicri:regionArea>
<wicri:noRegion>Kuopio</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Spiru, Luiza" sort="Spiru, Luiza" uniqKey="Spiru L" first="Luiza" last="Spiru">Luiza Spiru</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Geriatrics-Gerontology-Gerontopsychiatry, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.</nlm:affiliation>
<country xml:lang="fr">Roumanie</country>
<wicri:regionArea>Department of Geriatrics-Gerontology-Gerontopsychiatry, Carol Davila University of Medicine and Pharmacy, Bucharest</wicri:regionArea>
<wicri:noRegion>Bucharest</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Struyfs, Hanne" sort="Struyfs, Hanne" uniqKey="Struyfs H" first="Hanne" last="Struyfs">Hanne Struyfs</name>
<affiliation wicri:level="4"><nlm:affiliation>Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp</wicri:regionArea>
<orgName type="university">Université d'Anvers</orgName>
<placeName><settlement type="city">Anvers</settlement>
<region>Région flamande</region>
<region type="district" nuts="2">Province d'Anvers</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Teunissen, Charlotte E" sort="Teunissen, Charlotte E" uniqKey="Teunissen C" first="Charlotte E" last="Teunissen">Charlotte E. Teunissen</name>
<affiliation wicri:level="3"><nlm:affiliation>Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tsolaki, Magda" sort="Tsolaki, Magda" uniqKey="Tsolaki M" first="Magda" last="Tsolaki">Magda Tsolaki</name>
<affiliation wicri:level="1"><nlm:affiliation>Third Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Third Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki</wicri:regionArea>
<wicri:noRegion>Thessaloniki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vandenberghe, Rik" sort="Vandenberghe, Rik" uniqKey="Vandenberghe R" first="Rik" last="Vandenberghe">Rik Vandenberghe</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory for Cognitive Neurology and Alzheimer Research Centre KU Leuven, Catholic University Leuven, Leuven, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Laboratory for Cognitive Neurology and Alzheimer Research Centre KU Leuven, Catholic University Leuven, Leuven</wicri:regionArea>
<wicri:noRegion>Leuven</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Verbeek, Marcel M" sort="Verbeek, Marcel M" uniqKey="Verbeek M" first="Marcel M" last="Verbeek">Marcel M. Verbeek</name>
<affiliation wicri:level="3"><nlm:affiliation>Departments of Neurology and Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Departments of Neurology and Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen</wicri:regionArea>
<placeName><settlement type="city">Nimègue</settlement>
<region type="province" nuts="2">Gueldre</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Villemagne, Victor L" sort="Villemagne, Victor L" uniqKey="Villemagne V" first="Victor L" last="Villemagne">Victor L. Villemagne</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Nuclear Medicine and Centre for PET, Austin Health, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Nuclear Medicine and Centre for PET, Austin Health, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vos, Stephanie J B" sort="Vos, Stephanie J B" uniqKey="Vos S" first="Stephanie J B" last="Vos">Stephanie J B. Vos</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht</wicri:regionArea>
<wicri:noRegion>Maastricht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Waalwijk Van Doorn, Linda J C" sort="Van Waalwijk Van Doorn, Linda J C" uniqKey="Van Waalwijk Van Doorn L" first="Linda J C" last="Van Waalwijk Van Doorn">Linda J C. Van Waalwijk Van Doorn</name>
<affiliation wicri:level="3"><nlm:affiliation>Departments of Neurology and Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Departments of Neurology and Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen</wicri:regionArea>
<placeName><settlement type="city">Nimègue</settlement>
<region type="province" nuts="2">Gueldre</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Waldemar, Gunhild" sort="Waldemar, Gunhild" uniqKey="Waldemar G" first="Gunhild" last="Waldemar">Gunhild Waldemar</name>
<affiliation wicri:level="1"><nlm:affiliation>Danish Dementia Research Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Danish Dementia Research Center, Department of Neurology, Rigshospitalet, University of Copenhagen</wicri:regionArea>
<wicri:noRegion>University of Copenhagen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wallin, Anders" sort="Wallin, Anders" uniqKey="Wallin A" first="Anders" last="Wallin">Anders Wallin</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal</wicri:regionArea>
<wicri:noRegion>Mölndal</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wallin, Sa K" sort="Wallin, Sa K" uniqKey="Wallin " first=" Sa K" last="Wallin"> Sa K. Wallin</name>
<affiliation wicri:level="1"><nlm:affiliation>Clinical Memory Research Unit, Clinical Sciences Malmö, Lund University, Lund, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Clinical Memory Research Unit, Clinical Sciences Malmö, Lund University, Lund</wicri:regionArea>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wiltfang, Jens" sort="Wiltfang, Jens" uniqKey="Wiltfang J" first="Jens" last="Wiltfang">Jens Wiltfang</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August University, Göttingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August University, Göttingen</wicri:regionArea>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Göttingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wolk, David A" sort="Wolk, David A" uniqKey="Wolk D" first="David A" last="Wolk">David A. Wolk</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, University of Pennsylvania, Philadelphia.</nlm:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">Philadelphie</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<wicri:orgArea>Department of Neurology, University of Pennsylvania</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Zboch, Marzena" sort="Zboch, Marzena" uniqKey="Zboch M" first="Marzena" last="Zboch">Marzena Zboch</name>
<affiliation wicri:level="1"><nlm:affiliation>Alzheimer Center, Wroclaw Medical University, Scinawa, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Alzheimer Center, Wroclaw Medical University, Scinawa</wicri:regionArea>
<wicri:noRegion>Scinawa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zetterberg, Henrik" sort="Zetterberg, Henrik" uniqKey="Zetterberg H" first="Henrik" last="Zetterberg">Henrik Zetterberg</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden87UCL Institute of Neurology, Queen Square, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden87UCL Institute of Neurology, Queen Square, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">JAMA</title>
<idno type="eISSN">1538-3598</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Age Factors</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Amyloid beta-Peptides (analysis)</term>
<term>Apolipoprotein E4 (genetics)</term>
<term>Biomarkers (analysis)</term>
<term>Brain (pathology)</term>
<term>Cerebrospinal Fluid (chemistry)</term>
<term>Cognitive Dysfunction (pathology)</term>
<term>Dementia (pathology)</term>
<term>Female</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Positron-Emission Tomography</term>
<term>Prevalence</term>
<term>Risk Factors</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Apolipoprotéine E4 (génétique)</term>
<term>Dysfonctionnement cognitif (anatomopathologie)</term>
<term>Démence (anatomopathologie)</term>
<term>Encéphale (anatomopathologie)</term>
<term>Facteurs de l'âge</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Liquide cérébrospinal ()</term>
<term>Marqueurs biologiques (analyse)</term>
<term>Mâle</term>
<term>Peptides bêta-amyloïdes (analyse)</term>
<term>Prévalence</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Tomographie par émission de positons</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Amyloid beta-Peptides</term>
<term>Biomarkers</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Apolipoprotein E4</term>
</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Marqueurs biologiques</term>
<term>Peptides bêta-amyloïdes</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Dysfonctionnement cognitif</term>
<term>Démence</term>
<term>Encéphale</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Cerebrospinal Fluid</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Apolipoprotéine E4</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term>
<term>Cognitive Dysfunction</term>
<term>Dementia</term>
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<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Age Factors</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Female</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Positron-Emission Tomography</term>
<term>Prevalence</term>
<term>Risk Factors</term>
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<term>Adulte d'âge moyen</term>
<term>Facteurs de l'âge</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Liquide cérébrospinal</term>
<term>Mâle</term>
<term>Prévalence</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
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<front><div type="abstract" xml:lang="en">Cerebral amyloid-β aggregation is an early pathological event in Alzheimer disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid pathology in persons without dementia are needed to understand the development of AD and to design prevention studies.</div>
</front>
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<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25988462</PMID>
<DateCreated><Year>2015</Year>
<Month>05</Month>
<Day>20</Day>
</DateCreated>
<DateCompleted><Year>2015</Year>
<Month>05</Month>
<Day>22</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>04</Month>
<Day>20</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1538-3598</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>313</Volume>
<Issue>19</Issue>
<PubDate><Year>2015</Year>
<Month>May</Month>
<Day>19</Day>
</PubDate>
</JournalIssue>
<Title>JAMA</Title>
<ISOAbbreviation>JAMA</ISOAbbreviation>
</Journal>
<ArticleTitle>Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.</ArticleTitle>
<Pagination><MedlinePgn>1924-38</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1001/jama.2015.4668</ELocationID>
<Abstract><AbstractText Label="IMPORTANCE" NlmCategory="OBJECTIVE">Cerebral amyloid-β aggregation is an early pathological event in Alzheimer disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid pathology in persons without dementia are needed to understand the development of AD and to design prevention studies.</AbstractText>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To use individual participant data meta-analysis to estimate the prevalence of amyloid pathology as measured with biomarkers in participants with normal cognition, subjective cognitive impairment (SCI), or mild cognitive impairment (MCI).</AbstractText>
<AbstractText Label="DATA SOURCES" NlmCategory="METHODS">Relevant biomarker studies identified by searching studies published before April 2015 using the MEDLINE and Web of Science databases and through personal communication with investigators.</AbstractText>
<AbstractText Label="STUDY SELECTION" NlmCategory="METHODS">Studies were included if they provided individual participant data for participants without dementia and used an a priori defined cutoff for amyloid positivity.</AbstractText>
<AbstractText Label="DATA EXTRACTION AND SYNTHESIS" NlmCategory="METHODS">Individual records were provided for 2914 participants with normal cognition, 697 with SCI, and 3972 with MCI aged 18 to 100 years from 55 studies.</AbstractText>
<AbstractText Label="MAIN OUTCOMES AND MEASURES" NlmCategory="METHODS">Prevalence of amyloid pathology on positron emission tomography or in cerebrospinal fluid according to AD risk factors (age, apolipoprotein E [APOE] genotype, sex, and education) estimated by generalized estimating equations.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The prevalence of amyloid pathology increased from age 50 to 90 years from 10% (95% CI, 8%-13%) to 44% (95% CI, 37%-51%) among participants with normal cognition; from 12% (95% CI, 8%-18%) to 43% (95% CI, 32%-55%) among patients with SCI; and from 27% (95% CI, 23%-32%) to 71% (95% CI, 66%-76%) among patients with MCI. APOE-ε4 carriers had 2 to 3 times higher prevalence estimates than noncarriers. The age at which 15% of the participants with normal cognition were amyloid positive was approximately 40 years for APOE ε4ε4 carriers, 50 years for ε2ε4 carriers, 55 years for ε3ε4 carriers, 65 years for ε3ε3 carriers, and 95 years for ε2ε3 carriers. Amyloid positivity was more common in highly educated participants but not associated with sex or biomarker modality.</AbstractText>
<AbstractText Label="CONCLUSIONS AND RELEVANCE" NlmCategory="CONCLUSIONS">Among persons without dementia, the prevalence of cerebral amyloid pathology as determined by positron emission tomography or cerebrospinal fluid findings was associated with age, APOE genotype, and presence of cognitive impairment. These findings suggest a 20- to 30-year interval between first development of amyloid positivity and onset of dementia.</AbstractText>
</Abstract>
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