Comparison of serious inhaler technique errors made by device-naïve patients using three different dry powder inhalers: a randomised, crossover, open-label study.
Identifieur interne : 002155 ( PubMed/Checkpoint ); précédent : 002154; suivant : 002156Comparison of serious inhaler technique errors made by device-naïve patients using three different dry powder inhalers: a randomised, crossover, open-label study.
Auteurs : Henry Chrystyn [Royaume-Uni] ; David B. Price [Royaume-Uni] ; Mathieu Molimard [France] ; John Haughney [Royaume-Uni] ; Sinthia Bosnic-Anticevich [Australie] ; Federico Lavorini [Italie] ; John Efthimiou [Royaume-Uni] ; Dawn Shan [Royaume-Uni] ; Erika Sims [Royaume-Uni] ; Anne Burden [Royaume-Uni] ; Catherine Hutton [Royaume-Uni] ; Nicolas Roche [France]Source :
- BMC pulmonary medicine [ 1471-2466 ] ; 2016.
Descripteurs français
- KwdFr :
- Administration par inhalation, Adulte, Adulte d'âge moyen, Agonistes bêta-adrénergiques (administration et posologie), Asthme (traitement médicamenteux), Broncho-pneumopathie chronique obstructive (traitement médicamenteux), Conception d'appareillage, Femelle, Hormones corticosurrénaliennes (administration et posologie), Humains, Inhalateurs à poudre sèche, Mâle, Odds ratio, Sujet âgé, Études croisées.
- MESH :
- administration et posologie : Agonistes bêta-adrénergiques, Hormones corticosurrénaliennes.
- traitement médicamenteux : Asthme, Broncho-pneumopathie chronique obstructive.
- Administration par inhalation, Adulte, Adulte d'âge moyen, Conception d'appareillage, Femelle, Humains, Inhalateurs à poudre sèche, Mâle, Odds ratio, Sujet âgé, Études croisées.
English descriptors
- KwdEn :
- Administration, Inhalation, Adrenal Cortex Hormones (administration & dosage), Adrenergic beta-Agonists (administration & dosage), Adult, Aged, Asthma (drug therapy), Cross-Over Studies, Dry Powder Inhalers, Equipment Design, Female, Humans, Male, Middle Aged, Odds Ratio, Pulmonary Disease, Chronic Obstructive (drug therapy).
- MESH :
- chemical , administration & dosage : Adrenal Cortex Hormones, Adrenergic beta-Agonists.
- drug therapy : Asthma, Pulmonary Disease, Chronic Obstructive.
- Administration, Inhalation, Adult, Aged, Cross-Over Studies, Dry Powder Inhalers, Equipment Design, Female, Humans, Male, Middle Aged, Odds Ratio.
Abstract
Serious inhaler technique errors can impair drug delivery to the lungs. This randomised, crossover, open-label study evaluated the proportion of patients making predefined serious errors with Pulmojet compared with Diskus and Turbohaler dry powder inhalers.
DOI: 10.1186/s12890-016-0169-5
PubMed: 26769482
Affiliations:
- Australie, France, Italie, Royaume-Uni
- Angleterre, Aquitaine, Nouvelle-Aquitaine, Nouvelle-Galles du Sud, Oxfordshire, Île-de-France
- Bordeaux, Oxford, Paris, Sydney
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pubmed:26769482Le document en format XML
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Chrystyn</name><affiliation wicri:level="1"><nlm:affiliation>Inhalation Consultancy Ltd, Yeadon, Leeds, West Yorkshire, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Inhalation Consultancy Ltd, Yeadon, Leeds, West Yorkshire</wicri:regionArea><wicri:noRegion>West Yorkshire</wicri:noRegion></affiliation></author><author><name sortKey="Price, David B" sort="Price, David B" uniqKey="Price D" first="David B" last="Price">David B. Price</name><affiliation wicri:level="1"><nlm:affiliation>Research in Real-Life, 5a Coles Lane, Oakington, Cambridge, UK. dprice@rirl.org.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Research in Real-Life, 5a Coles Lane, Oakington, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Molimard, Mathieu" sort="Molimard, Mathieu" uniqKey="Molimard M" first="Mathieu" last="Molimard">Mathieu Molimard</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Pharmacology, CHU et Univ. de Bordeaux, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Medical Pharmacology, CHU et Univ. de Bordeaux, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Haughney, John" sort="Haughney, John" uniqKey="Haughney J" first="John" last="Haughney">John Haughney</name><affiliation wicri:level="1"><nlm:affiliation>Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, AB25 2ZD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, AB25 2ZD</wicri:regionArea><wicri:noRegion>AB25 2ZD</wicri:noRegion></affiliation></author><author><name sortKey="Bosnic Anticevich, Sinthia" sort="Bosnic Anticevich, Sinthia" uniqKey="Bosnic Anticevich S" first="Sinthia" last="Bosnic-Anticevich">Sinthia Bosnic-Anticevich</name><affiliation wicri:level="3"><nlm:affiliation>Woolcock Institute of Medical Research, Sydney Medical School, University of Sydney and Sydney Local Health District, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Woolcock Institute of Medical Research, Sydney Medical School, University of Sydney and Sydney Local Health District, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Lavorini, Federico" sort="Lavorini, Federico" uniqKey="Lavorini F" first="Federico" last="Lavorini">Federico Lavorini</name><affiliation wicri:level="1"><nlm:affiliation>Department of Experimental and Clinical Medicine, Careggi University Hospital, Florence, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental and Clinical Medicine, Careggi University Hospital, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Efthimiou, John" sort="Efthimiou, John" uniqKey="Efthimiou J" first="John" last="Efthimiou">John Efthimiou</name><affiliation wicri:level="3"><nlm:affiliation>Horizon Respiratory Consultancy, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Horizon Respiratory Consultancy, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Shan, Dawn" sort="Shan, Dawn" uniqKey="Shan D" first="Dawn" last="Shan">Dawn Shan</name><affiliation wicri:level="1"><nlm:affiliation>Research in Real-Life, 5a Coles Lane, Oakington, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Research in Real-Life, 5a Coles Lane, Oakington, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Sims, Erika" sort="Sims, Erika" uniqKey="Sims E" first="Erika" last="Sims">Erika Sims</name><affiliation wicri:level="1"><nlm:affiliation>Research in Real-Life, 5a Coles Lane, Oakington, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Research in Real-Life, 5a Coles Lane, Oakington, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Burden, Anne" sort="Burden, Anne" uniqKey="Burden A" first="Anne" last="Burden">Anne Burden</name><affiliation wicri:level="1"><nlm:affiliation>Research in Real-Life, 5a Coles Lane, Oakington, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Research in Real-Life, 5a Coles Lane, Oakington, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Hutton, Catherine" sort="Hutton, Catherine" uniqKey="Hutton C" first="Catherine" last="Hutton">Catherine Hutton</name><affiliation wicri:level="1"><nlm:affiliation>Research in Real-Life, 5a Coles Lane, Oakington, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Research in Real-Life, 5a Coles Lane, Oakington, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Roche, Nicolas" sort="Roche, Nicolas" uniqKey="Roche N" first="Nicolas" last="Roche">Nicolas Roche</name><affiliation wicri:level="3"><nlm:affiliation>University Paris Descartes (EA2511), Respiratory and Intensive Care Medicine Department, Cochin Hospital Group, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University Paris Descartes (EA2511), Respiratory and Intensive Care Medicine Department, Cochin Hospital Group, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">BMC pulmonary medicine</title><idno type="eISSN">1471-2466</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Inhalation</term><term>Adrenal Cortex Hormones (administration & dosage)</term><term>Adrenergic beta-Agonists (administration & dosage)</term><term>Adult</term><term>Aged</term><term>Asthma (drug therapy)</term><term>Cross-Over Studies</term><term>Dry Powder Inhalers</term><term>Equipment Design</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Odds Ratio</term><term>Pulmonary Disease, Chronic Obstructive (drug therapy)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Administration par inhalation</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Agonistes bêta-adrénergiques (administration et posologie)</term><term>Asthme (traitement médicamenteux)</term><term>Broncho-pneumopathie chronique obstructive (traitement médicamenteux)</term><term>Conception d'appareillage</term><term>Femelle</term><term>Hormones corticosurrénaliennes (administration et posologie)</term><term>Humains</term><term>Inhalateurs à poudre sèche</term><term>Mâle</term><term>Odds ratio</term><term>Sujet âgé</term><term>Études croisées</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Adrenal Cortex Hormones</term><term>Adrenergic beta-Agonists</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Agonistes bêta-adrénergiques</term><term>Hormones corticosurrénaliennes</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Asthma</term><term>Pulmonary Disease, Chronic Obstructive</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Asthme</term><term>Broncho-pneumopathie chronique obstructive</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Inhalation</term><term>Adult</term><term>Aged</term><term>Cross-Over Studies</term><term>Dry Powder Inhalers</term><term>Equipment Design</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Odds Ratio</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Administration par inhalation</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Conception d'appareillage</term><term>Femelle</term><term>Humains</term><term>Inhalateurs à poudre sèche</term><term>Mâle</term><term>Odds ratio</term><term>Sujet âgé</term><term>Études croisées</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Serious inhaler technique errors can impair drug delivery to the lungs. This randomised, crossover, open-label study evaluated the proportion of patients making predefined serious errors with Pulmojet compared with Diskus and Turbohaler dry powder inhalers.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26769482</PMID><DateCreated><Year>2016</Year><Month>01</Month><Day>15</Day></DateCreated><DateCompleted><Year>2016</Year><Month>10</Month><Day>05</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>23</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1471-2466</ISSN><JournalIssue CitedMedium="Internet"><Volume>16</Volume><PubDate><Year>2016</Year><Month>Jan</Month><Day>14</Day></PubDate></JournalIssue><Title>BMC pulmonary medicine</Title><ISOAbbreviation>BMC Pulm Med</ISOAbbreviation></Journal><ArticleTitle>Comparison of serious inhaler technique errors made by device-naïve patients using three different dry powder inhalers: a randomised, crossover, open-label study.</ArticleTitle><Pagination><MedlinePgn>12</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s12890-016-0169-5</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Serious inhaler technique errors can impair drug delivery to the lungs. This randomised, crossover, open-label study evaluated the proportion of patients making predefined serious errors with Pulmojet compared with Diskus and Turbohaler dry powder inhalers.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Patients ≥18 years old with asthma and/or COPD who were current users of an inhaler but naïve to the study devices were assigned to inhaler technique assessment on Pulmojet and either Diskus or Turbohaler in a randomised order. Patients inhaled through empty devices after reading the patient information leaflet. If serious errors potentially affecting dose delivery were recorded, they repeated the inhalations after watching a training video. Inhaler technique was assessed by a trained nurse observer and an electronic inhalation profile recorder.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Baseline patient characteristics were similar between randomisation arms for the Pulmojet-Diskus (n = 277) and Pulmojet-Turbohaler (n = 144) comparisons. Non-inferiority in the proportions of patients recording no nurse-observed serious errors was demonstrated for both Pulmojet versus Diskus, and Pulmojet versus Turbohaler; therefore, superiority was tested. Patients were significantly less likely to make ≥1 nurse-observed serious errors using Pulmojet compared with Diskus (odds ratio, 0.31; 95 % CI, 0.19-0.51) or Pulmojet compared with Turbohaler (0.23; 0.12-0.44) after reading the patient information leaflet with additional video instruction, if required.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These results suggest Pulmojet is easier to learn to use correctly than the Turbohaler or Diskus for current inhaler users switching to a new dry powder inhaler.</AbstractText><AbstractText Label="TRIAL REGISTRATION" NlmCategory="BACKGROUND">ClinicalTrials.gov Identifier: NCT01794390 (February 14, 2013).</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chrystyn</LastName><ForeName>Henry</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Inhalation Consultancy Ltd, Yeadon, Leeds, West Yorkshire, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Research in Real-Life, 5a Coles Lane, Oakington, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Price</LastName><ForeName>David B</ForeName><Initials>DB</Initials><AffiliationInfo><Affiliation>Research in Real-Life, 5a Coles Lane, Oakington, Cambridge, UK. dprice@rirl.org.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, AB25 2ZD, UK. dprice@rirl.org.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Molimard</LastName><ForeName>Mathieu</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medical Pharmacology, CHU et Univ. de Bordeaux, Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haughney</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, AB25 2ZD, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bosnic-Anticevich</LastName><ForeName>Sinthia</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Woolcock Institute of Medical Research, Sydney Medical School, University of Sydney and Sydney Local Health District, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lavorini</LastName><ForeName>Federico</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Experimental and Clinical Medicine, Careggi University Hospital, Florence, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Efthimiou</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Horizon Respiratory Consultancy, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shan</LastName><ForeName>Dawn</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Research in Real-Life, 5a Coles Lane, Oakington, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sims</LastName><ForeName>Erika</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Research in Real-Life, 5a Coles Lane, Oakington, Cambridge, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Burden</LastName><ForeName>Anne</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Research in Real-Life, 5a Coles Lane, Oakington, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hutton</LastName><ForeName>Catherine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Research in Real-Life, 5a Coles Lane, Oakington, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Roche</LastName><ForeName>Nicolas</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>University Paris Descartes (EA2511), Respiratory and Intensive Care Medicine Department, Cochin Hospital Group, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT01794390</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>01</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>BMC Pulm Med</MedlineTA><NlmUniqueID>100968563</NlmUniqueID><ISSNLinking>1471-2466</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000305">Adrenal Cortex Hormones</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000318">Adrenergic beta-Agonists</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>J Asthma. 2010 Apr;47(3):251-6</RefSource><PMID Version="1">20394511</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur Rev Med Pharmacol Sci. 2011 May;15(5):563-70</RefSource><PMID Version="1">21744753</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>BMC Pulm Med. 2006;6 Suppl 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Version="1">14572322</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Respir Med. 2015 Apr;109(4):451-8</RefSource><PMID Version="1">25771037</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Patient Educ Couns. 2008 Jul;72(1):26-33</RefSource><PMID Version="1">18314294</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Respir Med. 2008 Apr;102(4):593-604</RefSource><PMID Version="1">18083019</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Respir Med. 2008 Jan;102(1):10-9</RefSource><PMID Version="1">17923402</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000280" MajorTopicYN="N">Administration, Inhalation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000305" MajorTopicYN="N">Adrenal Cortex Hormones</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000318" MajorTopicYN="N">Adrenergic beta-Agonists</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001249" MajorTopicYN="N">Asthma</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018592" MajorTopicYN="N">Cross-Over Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058995" MajorTopicYN="Y">Dry Powder Inhalers</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004867" MajorTopicYN="Y">Equipment Design</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016017" MajorTopicYN="N">Odds Ratio</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D029424" MajorTopicYN="N">Pulmonary Disease, Chronic Obstructive</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4712500</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>05</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>01</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>1</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>1</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>10</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26769482</ArticleId><ArticleId IdType="doi">10.1186/s12890-016-0169-5</ArticleId><ArticleId IdType="pii">10.1186/s12890-016-0169-5</ArticleId><ArticleId IdType="pmc">PMC4712500</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>France</li><li>Italie</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Aquitaine</li><li>Nouvelle-Aquitaine</li><li>Nouvelle-Galles du Sud</li><li>Oxfordshire</li><li>Île-de-France</li></region><settlement><li>Bordeaux</li><li>Oxford</li><li>Paris</li><li>Sydney</li></settlement></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Chrystyn, Henry" sort="Chrystyn, Henry" uniqKey="Chrystyn H" first="Henry" last="Chrystyn">Henry Chrystyn</name></noRegion><name sortKey="Burden, Anne" sort="Burden, Anne" uniqKey="Burden A" first="Anne" last="Burden">Anne Burden</name><name sortKey="Efthimiou, John" sort="Efthimiou, John" uniqKey="Efthimiou J" first="John" last="Efthimiou">John Efthimiou</name><name sortKey="Haughney, John" sort="Haughney, John" uniqKey="Haughney J" first="John" last="Haughney">John Haughney</name><name sortKey="Hutton, Catherine" sort="Hutton, Catherine" uniqKey="Hutton C" first="Catherine" last="Hutton">Catherine Hutton</name><name sortKey="Price, David B" sort="Price, David B" uniqKey="Price D" first="David B" last="Price">David B. Price</name><name sortKey="Shan, Dawn" sort="Shan, Dawn" uniqKey="Shan D" first="Dawn" last="Shan">Dawn Shan</name><name sortKey="Sims, Erika" sort="Sims, Erika" uniqKey="Sims E" first="Erika" last="Sims">Erika Sims</name></country><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Molimard, Mathieu" sort="Molimard, Mathieu" uniqKey="Molimard M" first="Mathieu" last="Molimard">Mathieu Molimard</name></region><name sortKey="Roche, Nicolas" sort="Roche, Nicolas" uniqKey="Roche N" first="Nicolas" last="Roche">Nicolas Roche</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Bosnic Anticevich, Sinthia" sort="Bosnic Anticevich, Sinthia" uniqKey="Bosnic Anticevich S" first="Sinthia" last="Bosnic-Anticevich">Sinthia Bosnic-Anticevich</name></region></country><country name="Italie"><noRegion><name sortKey="Lavorini, Federico" sort="Lavorini, Federico" uniqKey="Lavorini F" first="Federico" last="Lavorini">Federico Lavorini</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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