Killer Cell Immunoglobulin-Like Receptor-Ligand Matching and Outcomes after Unrelated Cord Blood Transplantation in Acute Myeloid Leukemia.
Identifieur interne : 001B58 ( PubMed/Checkpoint ); précédent : 001B57; suivant : 001B59Killer Cell Immunoglobulin-Like Receptor-Ligand Matching and Outcomes after Unrelated Cord Blood Transplantation in Acute Myeloid Leukemia.
Auteurs : Vanderson Rocha [Royaume-Uni] ; Annalisa Ruggeri [France] ; Stephen Spellman [États-Unis] ; Tao Wang [États-Unis] ; Ronald Sobecks [États-Unis] ; Franco Locatelli [Italie] ; Medhat Askar [États-Unis] ; Gerard Michel [France] ; William Arcese [Italie] ; Anna Paola Iori [Italie] ; Duncan Purtill [Australie] ; Robert Danby [Royaume-Uni] ; Guillermo F. Sanz [Espagne] ; Eliane Gluckman [Monaco] ; Mary Eapen [États-Unis]Source :
- Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation [ 1523-6536 ] ; 2016.
Abstract
The effect of killer cell immunoglobulin-like receptor (KIR)-ligand matching on outcomes after unrelated cord blood (CB) transplantation was studied in 461 patients with acute myeloid leukemia, categorizing KIR ligand for HLA-C groups C1 and C2 and Bw4. Donor-recipient HLA matching considered allele-level matching at HLA-A, -B, -C, and -DRB1. Separate analyses were conducted for 6-7/8 HLA-matched and 3-5/8 HLA-matched transplants because HLA matching confounded KIR-ligand matching (ie, KIR-ligand mismatching was less likely with better HLA matching). All patients received single CB unit and myeloablative conditioning. There were no significant differences in nonrelapse mortality (NRM), relapse, and overall mortality by KIR-ligand match status. However, among recipients of 3-5/8 HLA-matched transplants, NRM (HR, 2.26; P = .008) and overall mortality (HR, 1.78; P = .008) but not relapse were higher with KIR-ligand mismatched (host-versus-graft direction) compared with KIR-ligand matched transplants. These data do not support selecting CB units based on KIR-ligand match status for transplants mismatched at 1 or 2 HLA loci. Although transplants mismatched at 3 or more HLA loci are not recommended, avoiding KIR-ligand mismatching in this setting lowers mortality risks.
DOI: 10.1016/j.bbmt.2016.04.007
PubMed: 27090957
Affiliations:
- Australie, Espagne, France, Italie, Monaco, Royaume-Uni, États-Unis
- Angleterre, Latium, Minnesota, Ohio, Oxfordshire, Provence-Alpes-Côte d'Azur, Texas, Wisconsin, Île-de-France
- Marseille, Oxford, Paris, Rome
- Université d'Oxford
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nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Iori, Anna Paola" sort="Iori, Anna Paola" uniqKey="Iori A" first="Anna Paola" last="Iori">Anna Paola Iori</name><affiliation wicri:level="3"><nlm:affiliation>Dipartimento di Ematologia, University of Rome, La Sapienza, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Ematologia, University of Rome, La Sapienza, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Purtill, Duncan" sort="Purtill, Duncan" uniqKey="Purtill D" first="Duncan" last="Purtill">Duncan Purtill</name><affiliation wicri:level="1"><nlm:affiliation>BMT Unit, Royal Perth Hospital, Perth, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>BMT Unit, Royal Perth Hospital, 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Electronic address: vanderson.rocha@ouh.nhs.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Eurocord, Hôpital Saint Louis, Paris, France; Churchill Hospital and NHSBT, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Ruggeri, Annalisa" sort="Ruggeri, Annalisa" uniqKey="Ruggeri A" first="Annalisa" last="Ruggeri">Annalisa Ruggeri</name><affiliation wicri:level="3"><nlm:affiliation>Eurocord, Hôpital Saint Louis, Paris, France; Service d'Hematologie et therapie cellulaire, Hôpital Saint Antoine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Eurocord, Hôpital Saint Louis, Paris, France; Service d'Hematologie et therapie cellulaire, Hôpital Saint Antoine, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Spellman, Stephen" sort="Spellman, Stephen" uniqKey="Spellman S" first="Stephen" last="Spellman">Stephen Spellman</name><affiliation wicri:level="2"><nlm:affiliation>Center for International Blood and Marrow Transplant Research, National Marrow Donor Program, Minneapolis, Minnesota.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Center for International Blood and Marrow Transplant Research, National Marrow Donor Program, Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="Wang, Tao" sort="Wang, Tao" uniqKey="Wang T" first="Tao" last="Wang">Tao Wang</name><affiliation wicri:level="2"><nlm:affiliation>Division of Biostatistics, Medical College of Wisconsin, Milwaukee, Wisconsin.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Division of Biostatistics, Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author><author><name sortKey="Sobecks, Ronald" sort="Sobecks, Ronald" uniqKey="Sobecks R" first="Ronald" last="Sobecks">Ronald Sobecks</name><affiliation wicri:level="2"><nlm:affiliation>Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Locatelli, Franco" sort="Locatelli, Franco" uniqKey="Locatelli F" first="Franco" last="Locatelli">Franco Locatelli</name><affiliation wicri:level="1"><nlm:affiliation>IRCCS Ospedale Pediatrico Bambino Gesù, Rome and University of Pavia, Pavia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS Ospedale Pediatrico Bambino Gesù, Rome and University of Pavia, Pavia</wicri:regionArea><wicri:noRegion>Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Askar, Medhat" sort="Askar, Medhat" uniqKey="Askar M" first="Medhat" last="Askar">Medhat Askar</name><affiliation wicri:level="2"><nlm:affiliation>Baylor University Medical Center, Dallas, Texas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Baylor University Medical Center, Dallas</wicri:cityArea></affiliation></author><author><name sortKey="Michel, Gerard" sort="Michel, Gerard" uniqKey="Michel G" first="Gerard" last="Michel">Gerard Michel</name><affiliation wicri:level="3"><nlm:affiliation>Service d'hematologie, La Timone Hospital, University Hospital of Marseille, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'hematologie, La Timone Hospital, University Hospital of Marseille, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Arcese, William" sort="Arcese, William" uniqKey="Arcese W" first="William" last="Arcese">William Arcese</name><affiliation wicri:level="3"><nlm:affiliation>BMT Unit, Rome Transplant Network, University "Tor Vergata", Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>BMT Unit, Rome Transplant Network, University "Tor Vergata", Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Iori, Anna Paola" sort="Iori, Anna Paola" uniqKey="Iori A" first="Anna Paola" last="Iori">Anna Paola Iori</name><affiliation wicri:level="3"><nlm:affiliation>Dipartimento di Ematologia, University of Rome, La Sapienza, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Ematologia, University of Rome, La Sapienza, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Purtill, Duncan" sort="Purtill, Duncan" uniqKey="Purtill D" first="Duncan" last="Purtill">Duncan Purtill</name><affiliation wicri:level="1"><nlm:affiliation>BMT Unit, Royal Perth Hospital, Perth, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>BMT Unit, Royal Perth Hospital, Perth</wicri:regionArea><wicri:noRegion>Perth</wicri:noRegion></affiliation></author><author><name sortKey="Danby, Robert" sort="Danby, Robert" uniqKey="Danby R" first="Robert" last="Danby">Robert Danby</name><affiliation wicri:level="4"><nlm:affiliation>Churchill Hospital and NHSBT, University of Oxford, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Churchill Hospital and NHSBT, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Sanz, Guillermo F" sort="Sanz, Guillermo F" uniqKey="Sanz G" first="Guillermo F" last="Sanz">Guillermo F. Sanz</name><affiliation wicri:level="1"><nlm:affiliation>Hematology and Trasnplant Unit, Hospital Universitario La Fe, Valencia, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hematology and Trasnplant Unit, Hospital Universitario La Fe, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Gluckman, Eliane" sort="Gluckman, Eliane" uniqKey="Gluckman E" first="Eliane" last="Gluckman">Eliane Gluckman</name><affiliation wicri:level="1"><nlm:affiliation>Eurocord, Hôpital Saint Louis, Paris, France; Monacord, Centre Scientifique de Monaco, Monaco.</nlm:affiliation><country xml:lang="fr">Monaco</country><wicri:regionArea>Eurocord, Hôpital Saint Louis, Paris, France; Monacord, Centre Scientifique de Monaco</wicri:regionArea><wicri:noRegion>Centre Scientifique de Monaco</wicri:noRegion></affiliation></author><author><name sortKey="Eapen, Mary" sort="Eapen, Mary" uniqKey="Eapen M" first="Mary" last="Eapen">Mary Eapen</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author></analytic><series><title level="j">Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</title><idno type="eISSN">1523-6536</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The effect of killer cell immunoglobulin-like receptor (KIR)-ligand matching on outcomes after unrelated cord blood (CB) transplantation was studied in 461 patients with acute myeloid leukemia, categorizing KIR ligand for HLA-C groups C1 and C2 and Bw4. Donor-recipient HLA matching considered allele-level matching at HLA-A, -B, -C, and -DRB1. Separate analyses were conducted for 6-7/8 HLA-matched and 3-5/8 HLA-matched transplants because HLA matching confounded KIR-ligand matching (ie, KIR-ligand mismatching was less likely with better HLA matching). All patients received single CB unit and myeloablative conditioning. There were no significant differences in nonrelapse mortality (NRM), relapse, and overall mortality by KIR-ligand match status. However, among recipients of 3-5/8 HLA-matched transplants, NRM (HR, 2.26; P = .008) and overall mortality (HR, 1.78; P = .008) but not relapse were higher with KIR-ligand mismatched (host-versus-graft direction) compared with KIR-ligand matched transplants. These data do not support selecting CB units based on KIR-ligand match status for transplants mismatched at 1 or 2 HLA loci. Although transplants mismatched at 3 or more HLA loci are not recommended, avoiding KIR-ligand mismatching in this setting lowers mortality risks.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">27090957</PMID><DateCreated><Year>2016</Year><Month>06</Month><Day>13</Day></DateCreated><DateRevised><Year>2017</Year><Month>10</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1523-6536</ISSN><JournalIssue CitedMedium="Internet"><Volume>22</Volume><Issue>7</Issue><PubDate><Year>2016</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</Title><ISOAbbreviation>Biol. Blood Marrow Transplant.</ISOAbbreviation></Journal><ArticleTitle>Killer Cell Immunoglobulin-Like Receptor-Ligand Matching and Outcomes after Unrelated Cord Blood Transplantation in Acute Myeloid Leukemia.</ArticleTitle><Pagination><MedlinePgn>1284-1289</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1083-8791(16)30026-X</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.bbmt.2016.04.007</ELocationID><Abstract><AbstractText>The effect of killer cell immunoglobulin-like receptor (KIR)-ligand matching on outcomes after unrelated cord blood (CB) transplantation was studied in 461 patients with acute myeloid leukemia, categorizing KIR ligand for HLA-C groups C1 and C2 and Bw4. Donor-recipient HLA matching considered allele-level matching at HLA-A, -B, -C, and -DRB1. Separate analyses were conducted for 6-7/8 HLA-matched and 3-5/8 HLA-matched transplants because HLA matching confounded KIR-ligand matching (ie, KIR-ligand mismatching was less likely with better HLA matching). All patients received single CB unit and myeloablative conditioning. There were no significant differences in nonrelapse mortality (NRM), relapse, and overall mortality by KIR-ligand match status. However, among recipients of 3-5/8 HLA-matched transplants, NRM (HR, 2.26; P = .008) and overall mortality (HR, 1.78; P = .008) but not relapse were higher with KIR-ligand mismatched (host-versus-graft direction) compared with KIR-ligand matched transplants. These data do not support selecting CB units based on KIR-ligand match status for transplants mismatched at 1 or 2 HLA loci. Although transplants mismatched at 3 or more HLA loci are not recommended, avoiding KIR-ligand mismatching in this setting lowers mortality risks.</AbstractText><CopyrightInformation>Copyright © 2016 American Society for Blood and Marrow Transplantation. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rocha</LastName><ForeName>Vanderson</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Eurocord, Hôpital Saint Louis, Paris, France; Churchill Hospital and NHSBT, University of Oxford, Oxford, United Kingdom. Electronic address: vanderson.rocha@ouh.nhs.uk.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ruggeri</LastName><ForeName>Annalisa</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Eurocord, Hôpital Saint Louis, Paris, France; Service d'Hematologie et therapie cellulaire, Hôpital Saint Antoine, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Spellman</LastName><ForeName>Stephen</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Center for International Blood and Marrow Transplant Research, National Marrow Donor Program, Minneapolis, Minnesota.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Tao</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Division of Biostatistics, Medical College of Wisconsin, Milwaukee, Wisconsin.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sobecks</LastName><ForeName>Ronald</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Locatelli</LastName><ForeName>Franco</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>IRCCS Ospedale Pediatrico Bambino Gesù, Rome and University of Pavia, Pavia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Askar</LastName><ForeName>Medhat</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Baylor University Medical Center, Dallas, Texas.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Michel</LastName><ForeName>Gerard</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Service d'hematologie, La Timone Hospital, University Hospital of Marseille, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arcese</LastName><ForeName>William</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>BMT Unit, Rome Transplant Network, University "Tor Vergata", Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Iori</LastName><ForeName>Anna Paola</ForeName><Initials>AP</Initials><AffiliationInfo><Affiliation>Dipartimento di Ematologia, University of Rome, La Sapienza, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Purtill</LastName><ForeName>Duncan</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>BMT Unit, Royal Perth Hospital, Perth, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Danby</LastName><ForeName>Robert</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Churchill Hospital and NHSBT, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sanz</LastName><ForeName>Guillermo F</ForeName><Initials>GF</Initials><AffiliationInfo><Affiliation>Hematology and Trasnplant Unit, Hospital Universitario La Fe, Valencia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gluckman</LastName><ForeName>Eliane</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Eurocord, Hôpital Saint Louis, Paris, France; Monacord, Centre Scientifique de Monaco, Monaco.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eapen</LastName><ForeName>Mary</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>Eurocord, Cord Blood Committee Cellular Therapy Immunobiology Working Party of the European Group for Blood and Marrow Transplantation, Netcord, and the Center for International Blood and Marrow Transplant Research</CollectiveName></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>U24 CA076518</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>04</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Biol Blood Marrow Transplant</MedlineTA><NlmUniqueID>9600628</NlmUniqueID><ISSNLinking>1083-8791</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Bone Marrow Transplant. 2006 Sep;38(6):437-44</RefSource><PMID Version="1">16892071</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biol Blood Marrow Transplant. 2010 Apr;16(4):533-42</RefSource><PMID 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PubStatus="entrez"><Year>2016</Year><Month>4</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>4</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>4</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27090957</ArticleId><ArticleId IdType="pii">S1083-8791(16)30026-X</ArticleId><ArticleId IdType="doi">10.1016/j.bbmt.2016.04.007</ArticleId><ArticleId IdType="pmc">PMC4915071</ArticleId><ArticleId IdType="mid">NIHMS788548</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>Espagne</li><li>France</li><li>Italie</li><li>Monaco</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Latium</li><li>Minnesota</li><li>Ohio</li><li>Oxfordshire</li><li>Provence-Alpes-Côte d'Azur</li><li>Texas</li><li>Wisconsin</li><li>Île-de-France</li></region><settlement><li>Marseille</li><li>Oxford</li><li>Paris</li><li>Rome</li></settlement><orgName><li>Université d'Oxford</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Rocha, Vanderson" sort="Rocha, Vanderson" uniqKey="Rocha V" first="Vanderson" last="Rocha">Vanderson Rocha</name></region><name sortKey="Danby, Robert" sort="Danby, Robert" uniqKey="Danby R" first="Robert" last="Danby">Robert Danby</name></country><country name="France"><region name="Île-de-France"><name sortKey="Ruggeri, Annalisa" sort="Ruggeri, Annalisa" uniqKey="Ruggeri A" first="Annalisa" last="Ruggeri">Annalisa Ruggeri</name></region><name sortKey="Michel, Gerard" sort="Michel, Gerard" uniqKey="Michel G" first="Gerard" last="Michel">Gerard Michel</name></country><country name="États-Unis"><region name="Minnesota"><name sortKey="Spellman, Stephen" sort="Spellman, Stephen" uniqKey="Spellman S" first="Stephen" last="Spellman">Stephen Spellman</name></region><name sortKey="Askar, Medhat" sort="Askar, Medhat" uniqKey="Askar M" first="Medhat" last="Askar">Medhat Askar</name><name sortKey="Eapen, Mary" sort="Eapen, Mary" uniqKey="Eapen M" first="Mary" last="Eapen">Mary Eapen</name><name sortKey="Sobecks, Ronald" sort="Sobecks, Ronald" uniqKey="Sobecks R" first="Ronald" last="Sobecks">Ronald Sobecks</name><name sortKey="Wang, Tao" sort="Wang, Tao" uniqKey="Wang T" first="Tao" last="Wang">Tao Wang</name></country><country name="Italie"><noRegion><name sortKey="Locatelli, Franco" sort="Locatelli, Franco" uniqKey="Locatelli F" first="Franco" last="Locatelli">Franco Locatelli</name></noRegion><name sortKey="Arcese, William" sort="Arcese, William" uniqKey="Arcese W" first="William" last="Arcese">William Arcese</name><name sortKey="Iori, Anna Paola" sort="Iori, Anna Paola" uniqKey="Iori A" first="Anna Paola" last="Iori">Anna Paola Iori</name></country><country name="Australie"><noRegion><name sortKey="Purtill, Duncan" sort="Purtill, Duncan" uniqKey="Purtill D" first="Duncan" last="Purtill">Duncan Purtill</name></noRegion></country><country name="Espagne"><noRegion><name sortKey="Sanz, Guillermo F" sort="Sanz, Guillermo F" uniqKey="Sanz G" first="Guillermo F" last="Sanz">Guillermo F. Sanz</name></noRegion></country><country name="Monaco"><noRegion><name sortKey="Gluckman, Eliane" sort="Gluckman, Eliane" uniqKey="Gluckman E" first="Eliane" last="Gluckman">Eliane Gluckman</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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