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Regulatory T cells may participate in Helicobacter pylori persistence in gastric MALT lymphoma: lessons from an animal model.

Identifieur interne : 001770 ( PubMed/Checkpoint ); précédent : 001769; suivant : 001771

Regulatory T cells may participate in Helicobacter pylori persistence in gastric MALT lymphoma: lessons from an animal model.

Auteurs : Amandine Marine Laur [France] ; Pauline Floch [France] ; Lucie Chambonnier [France] ; Lucie Benejat [France] ; Victoria Korolik [Australie] ; Alban Giese [France] ; Pierre Dubus [France] ; Francis Mégraud [France] ; Antonio Bandeira [France] ; Philippe Lehours [France]

Source :

Oncotarget [ 1949-2553 ] ; 2016.

RBID : pubmed:26657504

Descripteurs français

English descriptors

Abstract

It has been postulated that the emergence of autoimmune gastritis in neonatal thymectomised (d3Tx) BALB/c mice may be a consequence of post-surgery deficit in Tregs. In this study, previously obtained samples from d3Tx mice were used in order to determine whether thymectomy creates a deficit in this T cell subset thereby allowing the emergence of autoimmune phenomena as a prerequisite for GML. The splenic Treg reserve and the local recruitment of these cells in the gastric mucosa were investigated using complementary molecular and immunohistochemistry approaches. Higher Foxp3/CD3 ratios were found in the spleen of non-infected d3Tx mice compared to non-thymectomised (NTx) controls. These results indicate a relative enrichment of Tregs following thymectomy in adult mice. The absence of Treg depletion in d3Tx mice is in line with the absence of auto-immune gastritis in non-infected d3Tx mice. Higher levels of T cell and Treg infiltration were also found in the stomach of GML-developing d3Tx mice versus NTx mice. Surprisingly, inflammatory scores inversely correlated with the bacterial inoculum. The presence of a small Treg containing compartment among gastric biopsies of GML developing d3Tx mice may play a role in perseverance of a minimal bacterial numbers thereby maintaining an antigen-dependent stimulation and proliferation.

DOI: 10.18632/oncotarget.6492
PubMed: 26657504

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<term>Disease Models, Animal</term>
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<term>Gastric Mucosa (pathology)</term>
<term>Helicobacter Infections (immunology)</term>
<term>Helicobacter Infections (microbiology)</term>
<term>Helicobacter Infections (pathology)</term>
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<term>Immunoenzyme Techniques</term>
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<term>Reverse Transcriptase Polymerase Chain Reaction</term>
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<term>Helicobacter Infections</term>
<term>Lymphoma, B-Cell, Marginal Zone</term>
<term>Lymphoma, Non-Hodgkin</term>
<term>Stomach Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Gastric Mucosa</term>
<term>Helicobacter Infections</term>
<term>Lymphoma, B-Cell, Marginal Zone</term>
<term>Lymphoma, Non-Hodgkin</term>
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<front><div type="abstract" xml:lang="en">It has been postulated that the emergence of autoimmune gastritis in neonatal thymectomised (d3Tx) BALB/c mice may be a consequence of post-surgery deficit in Tregs. In this study, previously obtained samples from d3Tx mice were used in order to determine whether thymectomy creates a deficit in this T cell subset thereby allowing the emergence of autoimmune phenomena as a prerequisite for GML. The splenic Treg reserve and the local recruitment of these cells in the gastric mucosa were investigated using complementary molecular and immunohistochemistry approaches. Higher Foxp3/CD3 ratios were found in the spleen of non-infected d3Tx mice compared to non-thymectomised (NTx) controls. These results indicate a relative enrichment of Tregs following thymectomy in adult mice. The absence of Treg depletion in d3Tx mice is in line with the absence of auto-immune gastritis in non-infected d3Tx mice. Higher levels of T cell and Treg infiltration were also found in the stomach of GML-developing d3Tx mice versus NTx mice. Surprisingly, inflammatory scores inversely correlated with the bacterial inoculum. The presence of a small Treg containing compartment among gastric biopsies of GML developing d3Tx mice may play a role in perseverance of a minimal bacterial numbers thereby maintaining an antigen-dependent stimulation and proliferation.</div>
</front>
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<Day>16</Day>
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<Day>13</Day>
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<Day>19</Day>
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<Title>Oncotarget</Title>
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<ArticleTitle>Regulatory T cells may participate in Helicobacter pylori persistence in gastric MALT lymphoma: lessons from an animal model.</ArticleTitle>
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<Abstract><AbstractText>It has been postulated that the emergence of autoimmune gastritis in neonatal thymectomised (d3Tx) BALB/c mice may be a consequence of post-surgery deficit in Tregs. In this study, previously obtained samples from d3Tx mice were used in order to determine whether thymectomy creates a deficit in this T cell subset thereby allowing the emergence of autoimmune phenomena as a prerequisite for GML. The splenic Treg reserve and the local recruitment of these cells in the gastric mucosa were investigated using complementary molecular and immunohistochemistry approaches. Higher Foxp3/CD3 ratios were found in the spleen of non-infected d3Tx mice compared to non-thymectomised (NTx) controls. These results indicate a relative enrichment of Tregs following thymectomy in adult mice. The absence of Treg depletion in d3Tx mice is in line with the absence of auto-immune gastritis in non-infected d3Tx mice. Higher levels of T cell and Treg infiltration were also found in the stomach of GML-developing d3Tx mice versus NTx mice. Surprisingly, inflammatory scores inversely correlated with the bacterial inoculum. The presence of a small Treg containing compartment among gastric biopsies of GML developing d3Tx mice may play a role in perseverance of a minimal bacterial numbers thereby maintaining an antigen-dependent stimulation and proliferation.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Laur</LastName>
<ForeName>Amandine Marine</ForeName>
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</AffiliationInfo>
<AffiliationInfo><Affiliation>INSERM U853, Bordeaux, France.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Floch</LastName>
<ForeName>Pauline</ForeName>
<Initials>P</Initials>
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<Initials>A</Initials>
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Regulatory T cells may participate in Helicobacter pylori persistence in gastric MALT lymphoma: lessons from an animal model.

Regulatory T cells may participate in Helicobacter pylori persistence in gastric MALT lymphoma: lessons from an animal model.

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