Regulatory T cells may participate in Helicobacter pylori persistence in gastric MALT lymphoma: lessons from an animal model.
Identifieur interne : 002352 ( PubMed/Curation ); précédent : 002351; suivant : 002353Regulatory T cells may participate in Helicobacter pylori persistence in gastric MALT lymphoma: lessons from an animal model.
Auteurs : Amandine Marine Laur [France] ; Pauline Floch [France] ; Lucie Chambonnier [France] ; Lucie Benejat [France] ; Victoria Korolik [Australie] ; Alban Giese [France] ; Pierre Dubus [France] ; Francis Mégraud [France] ; Antonio Bandeira [France] ; Philippe Lehours [France]Source :
- Oncotarget [ 1949-2553 ] ; 2016.
Descripteurs français
- KwdFr :
- ARN messager (génétique), Animaux, Helicobacter pylori (immunologie), Infections à Helicobacter (anatomopathologie), Infections à Helicobacter (immunologie), Infections à Helicobacter (microbiologie), Lymphocytes T régulateurs (immunologie), Lymphome B de la zone marginale (anatomopathologie), Lymphome B de la zone marginale (immunologie), Lymphome B de la zone marginale (microbiologie), Lymphome malin non hodgkinien (anatomopathologie), Lymphome malin non hodgkinien (immunologie), Lymphome malin non hodgkinien (microbiologie), Modèles animaux de maladie humaine, Muqueuse gastrique (anatomopathologie), Muqueuse gastrique (immunologie), Muqueuse gastrique (microbiologie), RT-PCR, Réaction de polymérisation en chaine en temps réel, Souris, Techniques immunoenzymatiques, Tumeurs de l'estomac (anatomopathologie), Tumeurs de l'estomac (immunologie), Tumeurs de l'estomac (microbiologie).
- MESH :
- anatomopathologie : Infections à Helicobacter, Lymphome B de la zone marginale, Lymphome malin non hodgkinien, Muqueuse gastrique, Tumeurs de l'estomac.
- génétique : ARN messager.
- immunologie : Helicobacter pylori, Infections à Helicobacter, Lymphocytes T régulateurs, Lymphome B de la zone marginale, Lymphome malin non hodgkinien, Muqueuse gastrique, Tumeurs de l'estomac.
- microbiologie : Infections à Helicobacter, Lymphome B de la zone marginale, Lymphome malin non hodgkinien, Muqueuse gastrique, Tumeurs de l'estomac.
- Animaux, Modèles animaux de maladie humaine, RT-PCR, Réaction de polymérisation en chaine en temps réel, Souris, Techniques immunoenzymatiques.
English descriptors
- KwdEn :
- Animals, Disease Models, Animal, Gastric Mucosa (immunology), Gastric Mucosa (microbiology), Gastric Mucosa (pathology), Helicobacter Infections (immunology), Helicobacter Infections (microbiology), Helicobacter Infections (pathology), Helicobacter pylori (immunology), Immunoenzyme Techniques, Lymphoma, B-Cell, Marginal Zone (immunology), Lymphoma, B-Cell, Marginal Zone (microbiology), Lymphoma, B-Cell, Marginal Zone (pathology), Lymphoma, Non-Hodgkin (immunology), Lymphoma, Non-Hodgkin (microbiology), Lymphoma, Non-Hodgkin (pathology), Mice, RNA, Messenger (genetics), Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Stomach Neoplasms (immunology), Stomach Neoplasms (microbiology), Stomach Neoplasms (pathology), T-Lymphocytes, Regulatory (immunology).
- MESH :
- chemical , genetics : RNA, Messenger.
- immunology : Gastric Mucosa, Helicobacter Infections, Helicobacter pylori, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Non-Hodgkin, Stomach Neoplasms, T-Lymphocytes, Regulatory.
- microbiology : Gastric Mucosa, Helicobacter Infections, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Non-Hodgkin, Stomach Neoplasms.
- pathology : Gastric Mucosa, Helicobacter Infections, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Non-Hodgkin, Stomach Neoplasms.
- Animals, Disease Models, Animal, Immunoenzyme Techniques, Mice, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction.
Abstract
It has been postulated that the emergence of autoimmune gastritis in neonatal thymectomised (d3Tx) BALB/c mice may be a consequence of post-surgery deficit in Tregs. In this study, previously obtained samples from d3Tx mice were used in order to determine whether thymectomy creates a deficit in this T cell subset thereby allowing the emergence of autoimmune phenomena as a prerequisite for GML. The splenic Treg reserve and the local recruitment of these cells in the gastric mucosa were investigated using complementary molecular and immunohistochemistry approaches. Higher Foxp3/CD3 ratios were found in the spleen of non-infected d3Tx mice compared to non-thymectomised (NTx) controls. These results indicate a relative enrichment of Tregs following thymectomy in adult mice. The absence of Treg depletion in d3Tx mice is in line with the absence of auto-immune gastritis in non-infected d3Tx mice. Higher levels of T cell and Treg infiltration were also found in the stomach of GML-developing d3Tx mice versus NTx mice. Surprisingly, inflammatory scores inversely correlated with the bacterial inoculum. The presence of a small Treg containing compartment among gastric biopsies of GML developing d3Tx mice may play a role in perseverance of a minimal bacterial numbers thereby maintaining an antigen-dependent stimulation and proliferation.
DOI: 10.18632/oncotarget.6492
PubMed: 26657504
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<term>Disease Models, Animal</term>
<term>Gastric Mucosa (immunology)</term>
<term>Gastric Mucosa (microbiology)</term>
<term>Gastric Mucosa (pathology)</term>
<term>Helicobacter Infections (immunology)</term>
<term>Helicobacter Infections (microbiology)</term>
<term>Helicobacter Infections (pathology)</term>
<term>Helicobacter pylori (immunology)</term>
<term>Immunoenzyme Techniques</term>
<term>Lymphoma, B-Cell, Marginal Zone (immunology)</term>
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<term>Lymphoma, Non-Hodgkin (immunology)</term>
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<term>Lymphoma, Non-Hodgkin (pathology)</term>
<term>Mice</term>
<term>RNA, Messenger (genetics)</term>
<term>Real-Time Polymerase Chain Reaction</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
<term>Stomach Neoplasms (immunology)</term>
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<term>Animaux</term>
<term>Helicobacter pylori (immunologie)</term>
<term>Infections à Helicobacter (anatomopathologie)</term>
<term>Infections à Helicobacter (immunologie)</term>
<term>Infections à Helicobacter (microbiologie)</term>
<term>Lymphocytes T régulateurs (immunologie)</term>
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<term>Lymphome B de la zone marginale (immunologie)</term>
<term>Lymphome B de la zone marginale (microbiologie)</term>
<term>Lymphome malin non hodgkinien (anatomopathologie)</term>
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<term>Modèles animaux de maladie humaine</term>
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<term>Helicobacter pylori</term>
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<term>Muqueuse gastrique</term>
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<front><div type="abstract" xml:lang="en">It has been postulated that the emergence of autoimmune gastritis in neonatal thymectomised (d3Tx) BALB/c mice may be a consequence of post-surgery deficit in Tregs. In this study, previously obtained samples from d3Tx mice were used in order to determine whether thymectomy creates a deficit in this T cell subset thereby allowing the emergence of autoimmune phenomena as a prerequisite for GML. The splenic Treg reserve and the local recruitment of these cells in the gastric mucosa were investigated using complementary molecular and immunohistochemistry approaches. Higher Foxp3/CD3 ratios were found in the spleen of non-infected d3Tx mice compared to non-thymectomised (NTx) controls. These results indicate a relative enrichment of Tregs following thymectomy in adult mice. The absence of Treg depletion in d3Tx mice is in line with the absence of auto-immune gastritis in non-infected d3Tx mice. Higher levels of T cell and Treg infiltration were also found in the stomach of GML-developing d3Tx mice versus NTx mice. Surprisingly, inflammatory scores inversely correlated with the bacterial inoculum. The presence of a small Treg containing compartment among gastric biopsies of GML developing d3Tx mice may play a role in perseverance of a minimal bacterial numbers thereby maintaining an antigen-dependent stimulation and proliferation.</div>
</front>
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<Abstract><AbstractText>It has been postulated that the emergence of autoimmune gastritis in neonatal thymectomised (d3Tx) BALB/c mice may be a consequence of post-surgery deficit in Tregs. In this study, previously obtained samples from d3Tx mice were used in order to determine whether thymectomy creates a deficit in this T cell subset thereby allowing the emergence of autoimmune phenomena as a prerequisite for GML. The splenic Treg reserve and the local recruitment of these cells in the gastric mucosa were investigated using complementary molecular and immunohistochemistry approaches. Higher Foxp3/CD3 ratios were found in the spleen of non-infected d3Tx mice compared to non-thymectomised (NTx) controls. These results indicate a relative enrichment of Tregs following thymectomy in adult mice. The absence of Treg depletion in d3Tx mice is in line with the absence of auto-immune gastritis in non-infected d3Tx mice. Higher levels of T cell and Treg infiltration were also found in the stomach of GML-developing d3Tx mice versus NTx mice. Surprisingly, inflammatory scores inversely correlated with the bacterial inoculum. The presence of a small Treg containing compartment among gastric biopsies of GML developing d3Tx mice may play a role in perseverance of a minimal bacterial numbers thereby maintaining an antigen-dependent stimulation and proliferation.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Laur</LastName>
<ForeName>Amandine Marine</ForeName>
<Initials>AM</Initials>
<AffiliationInfo><Affiliation>University Bordeaux, Bacteriology Laboratory, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>INSERM U853, Bordeaux, France.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Floch</LastName>
<ForeName>Pauline</ForeName>
<Initials>P</Initials>
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</AffiliationInfo>
<AffiliationInfo><Affiliation>INSERM U853, Bordeaux, France.</Affiliation>
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</Author>
<Author ValidYN="Y"><LastName>Chambonnier</LastName>
<ForeName>Lucie</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>University Bordeaux, Bacteriology Laboratory, Bordeaux, France.</Affiliation>
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<AffiliationInfo><Affiliation>INSERM U853, Bordeaux, France.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Benejat</LastName>
<ForeName>Lucie</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>University Bordeaux, Bacteriology Laboratory, Bordeaux, France.</Affiliation>
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<MeshHeading><DescriptorName UI="D012333" MajorTopicYN="N">RNA, Messenger</DescriptorName>
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<MeshHeading><DescriptorName UI="D060888" MajorTopicYN="N">Real-Time Polymerase Chain Reaction</DescriptorName>
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<MeshHeading><DescriptorName UI="D020133" MajorTopicYN="N">Reverse Transcriptase Polymerase Chain Reaction</DescriptorName>
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