Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study.
Identifieur interne : 001744 ( PubMed/Checkpoint ); précédent : 001743; suivant : 001745Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study.
Auteurs : Elena H. Martinez-Lapiscina [Espagne] ; Sam Arnow [États-Unis] ; James A. Wilson [États-Unis] ; Shiv Saidha [États-Unis] ; Jana Lizrova Preiningerova [République tchèque] ; Timm Oberwahrenbrock [Allemagne] ; Alexander U. Brandt [Allemagne] ; Luis E. Pablo [Espagne] ; Simone Guerrieri [Italie] ; Ines Gonzalez [Espagne] ; Olivier Outteryck [France] ; Ann-Kristin Mueller [Allemagne] ; Phillip Albrecht [Allemagne] ; Wesley Chan [Canada] ; Sebastian Lukas [Suisse] ; Lisanne J. Balk [Pays-Bas] ; Clare Fraser [Australie] ; Jette L. Frederiksen [Danemark] ; Jennifer Resto [États-Unis] ; Teresa Frohman [États-Unis] ; Christian Cordano [États-Unis] ; Irati Zubizarreta [Espagne] ; Magi Andorra [Espagne] ; Bernardo Sanchez-Dalmau [Espagne] ; Albert Saiz [Espagne] ; Robert Bermel [États-Unis] ; Alexander Klistorner [Australie] ; Axel Petzold [Royaume-Uni] ; Sven Schippling [Suisse] ; Fiona Costello [Canada] ; Orhan Aktas [Allemagne] ; Patrick Vermersch [France] ; Celia Oreja-Guevara [Espagne] ; Giancarlo Comi [Italie] ; Letizia Leocani [Italie] ; Elena Garcia-Martin [Espagne] ; Friedemann Paul [Allemagne] ; Eva Havrdova [République tchèque] ; Elliot Frohman [États-Unis] ; Laura J. Balcer [États-Unis] ; Ari J. Green [États-Unis] ; Peter A. Calabresi [États-Unis] ; Pablo Villoslada [États-Unis]Source :
- The Lancet. Neurology [ 1474-4465 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Femelle, Humains, Indice de gravité médicale, Macula (imagerie diagnostique), Mâle, Neurones rétiniens (anatomopathologie), Pronostic, Rétinopathies (imagerie diagnostique), Rétinopathies (étiologie), Sclérose en plaques (), Sclérose en plaques (physiopathologie), Tomographie par cohérence optique (), Études de cohortes, Études de suivi, Évolution de la maladie.
- MESH :
- anatomopathologie : Neurones rétiniens.
- imagerie diagnostique : Macula, Rétinopathies.
- physiopathologie : Sclérose en plaques.
- étiologie : Rétinopathies.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Indice de gravité médicale, Mâle, Pronostic, Sclérose en plaques, Tomographie par cohérence optique, Études de cohortes, Études de suivi, Évolution de la maladie.
English descriptors
- KwdEn :
- Adult, Cohort Studies, Disease Progression, Female, Follow-Up Studies, Humans, Macula Lutea (diagnostic imaging), Male, Middle Aged, Multiple Sclerosis (complications), Multiple Sclerosis (physiopathology), Prognosis, Retinal Diseases (diagnostic imaging), Retinal Diseases (etiology), Retinal Neurons (pathology), Severity of Illness Index, Tomography, Optical Coherence (methods).
- MESH :
- complications : Multiple Sclerosis.
- diagnostic imaging : Macula Lutea, Retinal Diseases.
- etiology : Retinal Diseases.
- methods : Tomography, Optical Coherence.
- pathology : Retinal Neurons.
- physiopathology : Multiple Sclerosis.
- Adult, Cohort Studies, Disease Progression, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prognosis, Severity of Illness Index.
Abstract
Most patients with multiple sclerosis without previous optic neuritis have thinner retinal layers than healthy controls. We assessed the role of peripapillary retinal nerve fibre layer (pRNFL) thickness and macular volume in eyes with no history of optic neuritis as a biomarker of disability worsening in a cohort of patients with multiple sclerosis who had at least one eye without optic neuritis available.
DOI: 10.1016/S1474-4422(16)00068-5
PubMed: 27011339
Affiliations:
- Allemagne, Australie, Canada, Danemark, Espagne, France, Italie, Pays-Bas, Royaume-Uni, République tchèque, Suisse, États-Unis
- Alberta, Angleterre, Berlin, Bohême centrale, Californie, Canton de Zurich, Catalogne, Communauté de Madrid, District de Düsseldorf, Grand Londres, Hauts-de-France, Hollande-Septentrionale, Lombardie, Maryland, Nord-Pas-de-Calais, Nouvelle-Galles du Sud, Ohio, Pennsylvanie, Rhénanie-du-Nord-Westphalie, Texas, État de New York
- Amsterdam, Barcelone, Berlin, Calgary, Düsseldorf, Lille, Londres, Madrid, Milan, Prague, Sydney, Zurich
- Université de Calgary, Université de Sydney, Université de Zurich
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pubmed:27011339Le document en format XML
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Martinez-Lapiscina</name><affiliation wicri:level="3"><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Arnow, Sam" sort="Arnow, Sam" uniqKey="Arnow S" first="Sam" last="Arnow">Sam Arnow</name><affiliation wicri:level="2"><nlm:affiliation>University of California, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of California, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Wilson, James A" sort="Wilson, James A" uniqKey="Wilson J" first="James A" last="Wilson">James A. 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Balk</name><affiliation wicri:level="3"><nlm:affiliation>VU Medical Center, Amsterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>VU Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Fraser, Clare" sort="Fraser, Clare" uniqKey="Fraser C" first="Clare" last="Fraser">Clare Fraser</name><affiliation wicri:level="4"><nlm:affiliation>Save Sight Institute, University of Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Save Sight Institute, University of Sydney, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Frederiksen, Jette L" sort="Frederiksen, Jette L" uniqKey="Frederiksen J" first="Jette L" last="Frederiksen">Jette L. Frederiksen</name><affiliation wicri:level="1"><nlm:affiliation>Glostrup Hospital, University of Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Glostrup Hospital, University of Copenhagen</wicri:regionArea><wicri:noRegion>University of Copenhagen</wicri:noRegion></affiliation></author><author><name sortKey="Resto, Jennifer" sort="Resto, Jennifer" uniqKey="Resto J" first="Jennifer" last="Resto">Jennifer Resto</name><affiliation wicri:level="2"><nlm:affiliation>Cleveland Clinic Foundation, Cleveland, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cleveland Clinic Foundation, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Frohman, Teresa" sort="Frohman, Teresa" uniqKey="Frohman T" first="Teresa" last="Frohman">Teresa Frohman</name><affiliation wicri:level="2"><nlm:affiliation>University of Texas Southwestern Medical Center, Dallas, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Texas Southwestern Medical Center, Dallas, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Cordano, Christian" sort="Cordano, Christian" uniqKey="Cordano C" first="Christian" last="Cordano">Christian Cordano</name><affiliation wicri:level="2"><nlm:affiliation>University of California, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of California, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Zubizarreta, Irati" sort="Zubizarreta, Irati" uniqKey="Zubizarreta I" first="Irati" last="Zubizarreta">Irati Zubizarreta</name><affiliation wicri:level="3"><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Andorra, Magi" sort="Andorra, Magi" uniqKey="Andorra M" first="Magi" last="Andorra">Magi Andorra</name><affiliation wicri:level="3"><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Sanchez Dalmau, Bernardo" sort="Sanchez Dalmau, Bernardo" uniqKey="Sanchez Dalmau B" first="Bernardo" last="Sanchez-Dalmau">Bernardo Sanchez-Dalmau</name><affiliation wicri:level="3"><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Saiz, Albert" sort="Saiz, Albert" uniqKey="Saiz A" first="Albert" last="Saiz">Albert Saiz</name><affiliation wicri:level="3"><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Bermel, Robert" sort="Bermel, Robert" uniqKey="Bermel R" first="Robert" last="Bermel">Robert Bermel</name><affiliation wicri:level="2"><nlm:affiliation>Cleveland Clinic Foundation, Cleveland, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cleveland Clinic Foundation, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Klistorner, Alexander" sort="Klistorner, Alexander" uniqKey="Klistorner A" first="Alexander" last="Klistorner">Alexander Klistorner</name><affiliation wicri:level="4"><nlm:affiliation>Save Sight Institute, University of Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Save Sight Institute, University of Sydney, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Petzold, Axel" sort="Petzold, Axel" uniqKey="Petzold A" first="Axel" last="Petzold">Axel Petzold</name><affiliation wicri:level="3"><nlm:affiliation>VU Medical Center, Amsterdam, Netherlands; Moorfields Eye Hospital, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>VU Medical Center, Amsterdam, Netherlands; Moorfields Eye Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Schippling, Sven" sort="Schippling, Sven" uniqKey="Schippling S" first="Sven" last="Schippling">Sven Schippling</name><affiliation wicri:level="4"><nlm:affiliation>University of Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>University of Zurich, Zurich</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Costello, Fiona" sort="Costello, Fiona" uniqKey="Costello F" first="Fiona" last="Costello">Fiona Costello</name><affiliation wicri:level="4"><nlm:affiliation>University of Calgary, Calgary, AB, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of Calgary, Calgary, AB</wicri:regionArea><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation></author><author><name sortKey="Aktas, Orhan" sort="Aktas, Orhan" uniqKey="Aktas O" first="Orhan" last="Aktas">Orhan Aktas</name><affiliation wicri:level="3"><nlm:affiliation>University of Düsseldorf, Düsseldorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Düsseldorf, Düsseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Vermersch, Patrick" sort="Vermersch, Patrick" uniqKey="Vermersch P" first="Patrick" last="Vermersch">Patrick Vermersch</name><affiliation wicri:level="3"><nlm:affiliation>University of Lille, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Oreja Guevara, Celia" sort="Oreja Guevara, Celia" uniqKey="Oreja Guevara C" first="Celia" last="Oreja-Guevara">Celia Oreja-Guevara</name><affiliation wicri:level="3"><nlm:affiliation>Hospital Clinico San Carlos, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Clinico San Carlos, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Comi, Giancarlo" sort="Comi, Giancarlo" uniqKey="Comi G" first="Giancarlo" last="Comi">Giancarlo Comi</name><affiliation wicri:level="3"><nlm:affiliation>San Raffaele Hospital, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>San Raffaele Hospital, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Leocani, Letizia" sort="Leocani, Letizia" uniqKey="Leocani L" first="Letizia" last="Leocani">Letizia Leocani</name><affiliation wicri:level="3"><nlm:affiliation>San Raffaele Hospital, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>San Raffaele Hospital, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Garcia Martin, Elena" sort="Garcia Martin, Elena" uniqKey="Garcia Martin E" first="Elena" last="Garcia-Martin">Elena Garcia-Martin</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Miguel Servet, Zaragoza, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Miguel Servet, Zaragoza</wicri:regionArea><wicri:noRegion>Zaragoza</wicri:noRegion></affiliation></author><author><name sortKey="Paul, Friedemann" sort="Paul, Friedemann" uniqKey="Paul F" first="Friedemann" last="Paul">Friedemann Paul</name><affiliation wicri:level="3"><nlm:affiliation>Experimental and Clinical Research Center and NeuroCure Clinical Research Center, Charité University Medicine and Max Delbrueck Center for Molecular Medicine, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Experimental and Clinical Research Center and NeuroCure Clinical Research Center, Charité University Medicine and Max Delbrueck Center for Molecular Medicine, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Havrdova, Eva" sort="Havrdova, Eva" uniqKey="Havrdova E" first="Eva" last="Havrdova">Eva Havrdova</name><affiliation wicri:level="3"><nlm:affiliation>Charles University, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Charles University, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Frohman, Elliot" sort="Frohman, Elliot" uniqKey="Frohman E" first="Elliot" last="Frohman">Elliot Frohman</name><affiliation wicri:level="2"><nlm:affiliation>University of Texas Southwestern Medical Center, Dallas, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Texas Southwestern Medical Center, Dallas, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Balcer, Laura J" sort="Balcer, Laura J" uniqKey="Balcer L" first="Laura J" last="Balcer">Laura J. Balcer</name><affiliation wicri:level="2"><nlm:affiliation>University of Pennsylvania, Philadelphia, PA, USA; New York University, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pennsylvania, Philadelphia, PA, USA; New York University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Green, Ari J" sort="Green, Ari J" uniqKey="Green A" first="Ari J" last="Green">Ari J. Green</name><affiliation wicri:level="2"><nlm:affiliation>University of California, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of California, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Calabresi, Peter A" sort="Calabresi, Peter A" uniqKey="Calabresi P" first="Peter A" last="Calabresi">Peter A. Calabresi</name><affiliation wicri:level="2"><nlm:affiliation>Johns Hopkins University, Baltimore, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins University, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Villoslada, Pablo" sort="Villoslada, Pablo" uniqKey="Villoslada P" first="Pablo" last="Villoslada">Pablo Villoslada</name><affiliation wicri:level="2"><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain; University of California, San Francisco, CA, USA. Electronic address: pvilloslada@clinic.ub.es.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain; University of California, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27011339</idno><idno type="pmid">27011339</idno><idno type="doi">10.1016/S1474-4422(16)00068-5</idno><idno type="wicri:Area/PubMed/Corpus">001F41</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001F41</idno><idno type="wicri:Area/PubMed/Curation">001F17</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001F17</idno><idno type="wicri:Area/PubMed/Checkpoint">001F17</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001F17</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study.</title><author><name sortKey="Martinez Lapiscina, Elena H" sort="Martinez Lapiscina, Elena H" uniqKey="Martinez Lapiscina E" first="Elena H" last="Martinez-Lapiscina">Elena H. Martinez-Lapiscina</name><affiliation wicri:level="3"><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Arnow, Sam" sort="Arnow, Sam" uniqKey="Arnow S" first="Sam" last="Arnow">Sam Arnow</name><affiliation wicri:level="2"><nlm:affiliation>University of California, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of California, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Wilson, James A" sort="Wilson, James A" uniqKey="Wilson J" first="James A" last="Wilson">James A. Wilson</name><affiliation wicri:level="2"><nlm:affiliation>University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pennsylvania, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Saidha, Shiv" sort="Saidha, Shiv" uniqKey="Saidha S" first="Shiv" last="Saidha">Shiv Saidha</name><affiliation wicri:level="2"><nlm:affiliation>Johns Hopkins University, Baltimore, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins University, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Preiningerova, Jana Lizrova" sort="Preiningerova, Jana Lizrova" uniqKey="Preiningerova J" first="Jana Lizrova" last="Preiningerova">Jana Lizrova Preiningerova</name><affiliation wicri:level="3"><nlm:affiliation>Charles University, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Charles University, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Oberwahrenbrock, Timm" sort="Oberwahrenbrock, Timm" uniqKey="Oberwahrenbrock T" first="Timm" last="Oberwahrenbrock">Timm Oberwahrenbrock</name><affiliation wicri:level="3"><nlm:affiliation>Experimental and Clinical Research Center and NeuroCure Clinical Research Center, Charité University Medicine and Max Delbrueck Center for Molecular Medicine, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Experimental and Clinical Research Center and NeuroCure Clinical Research Center, Charité University Medicine and Max Delbrueck Center for Molecular Medicine, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Brandt, Alexander U" sort="Brandt, Alexander U" uniqKey="Brandt A" first="Alexander U" last="Brandt">Alexander U. Brandt</name><affiliation wicri:level="3"><nlm:affiliation>Experimental and Clinical Research Center and NeuroCure Clinical Research Center, Charité University Medicine and Max Delbrueck Center for Molecular Medicine, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Experimental and Clinical Research Center and NeuroCure Clinical Research Center, Charité University Medicine and Max Delbrueck Center for Molecular Medicine, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Pablo, Luis E" sort="Pablo, Luis E" uniqKey="Pablo L" first="Luis E" last="Pablo">Luis E. Pablo</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Miguel Servet, Zaragoza, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Miguel Servet, Zaragoza</wicri:regionArea><wicri:noRegion>Zaragoza</wicri:noRegion></affiliation></author><author><name sortKey="Guerrieri, Simone" sort="Guerrieri, Simone" uniqKey="Guerrieri S" first="Simone" last="Guerrieri">Simone Guerrieri</name><affiliation wicri:level="3"><nlm:affiliation>San Raffaele Hospital, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>San Raffaele Hospital, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Gonzalez, Ines" sort="Gonzalez, Ines" uniqKey="Gonzalez I" first="Ines" last="Gonzalez">Ines Gonzalez</name><affiliation wicri:level="3"><nlm:affiliation>Hospital Clinico San Carlos, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Clinico San Carlos, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Outteryck, Olivier" sort="Outteryck, Olivier" uniqKey="Outteryck O" first="Olivier" last="Outteryck">Olivier Outteryck</name><affiliation wicri:level="3"><nlm:affiliation>University of Lille, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Mueller, Ann Kristin" sort="Mueller, Ann Kristin" uniqKey="Mueller A" first="Ann-Kristin" last="Mueller">Ann-Kristin Mueller</name><affiliation wicri:level="3"><nlm:affiliation>University of Düsseldorf, Düsseldorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Düsseldorf, Düsseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Albrecht, Phillip" sort="Albrecht, Phillip" uniqKey="Albrecht P" first="Phillip" last="Albrecht">Phillip Albrecht</name><affiliation wicri:level="3"><nlm:affiliation>University of Düsseldorf, Düsseldorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Düsseldorf, Düsseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Chan, Wesley" sort="Chan, Wesley" uniqKey="Chan W" first="Wesley" last="Chan">Wesley Chan</name><affiliation wicri:level="4"><nlm:affiliation>University of Calgary, Calgary, AB, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of Calgary, Calgary, AB</wicri:regionArea><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation></author><author><name sortKey="Lukas, Sebastian" sort="Lukas, Sebastian" uniqKey="Lukas S" first="Sebastian" last="Lukas">Sebastian Lukas</name><affiliation wicri:level="4"><nlm:affiliation>University of Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>University of Zurich, Zurich</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Balk, Lisanne J" sort="Balk, Lisanne J" uniqKey="Balk L" first="Lisanne J" last="Balk">Lisanne J. Balk</name><affiliation wicri:level="3"><nlm:affiliation>VU Medical Center, Amsterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>VU Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Fraser, Clare" sort="Fraser, Clare" uniqKey="Fraser C" first="Clare" last="Fraser">Clare Fraser</name><affiliation wicri:level="4"><nlm:affiliation>Save Sight Institute, University of Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Save Sight Institute, University of Sydney, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Frederiksen, Jette L" sort="Frederiksen, Jette L" uniqKey="Frederiksen J" first="Jette L" last="Frederiksen">Jette L. Frederiksen</name><affiliation wicri:level="1"><nlm:affiliation>Glostrup Hospital, University of Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Glostrup Hospital, University of Copenhagen</wicri:regionArea><wicri:noRegion>University of Copenhagen</wicri:noRegion></affiliation></author><author><name sortKey="Resto, Jennifer" sort="Resto, Jennifer" uniqKey="Resto J" first="Jennifer" last="Resto">Jennifer Resto</name><affiliation wicri:level="2"><nlm:affiliation>Cleveland Clinic Foundation, Cleveland, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cleveland Clinic Foundation, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Frohman, Teresa" sort="Frohman, Teresa" uniqKey="Frohman T" first="Teresa" last="Frohman">Teresa Frohman</name><affiliation wicri:level="2"><nlm:affiliation>University of Texas Southwestern Medical Center, Dallas, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Texas Southwestern Medical Center, Dallas, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Cordano, Christian" sort="Cordano, Christian" uniqKey="Cordano C" first="Christian" last="Cordano">Christian Cordano</name><affiliation wicri:level="2"><nlm:affiliation>University of California, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of California, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Zubizarreta, Irati" sort="Zubizarreta, Irati" uniqKey="Zubizarreta I" first="Irati" last="Zubizarreta">Irati Zubizarreta</name><affiliation wicri:level="3"><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Andorra, Magi" sort="Andorra, Magi" uniqKey="Andorra M" first="Magi" last="Andorra">Magi Andorra</name><affiliation wicri:level="3"><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Sanchez Dalmau, Bernardo" sort="Sanchez Dalmau, Bernardo" uniqKey="Sanchez Dalmau B" first="Bernardo" last="Sanchez-Dalmau">Bernardo Sanchez-Dalmau</name><affiliation wicri:level="3"><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Saiz, Albert" sort="Saiz, Albert" uniqKey="Saiz A" first="Albert" last="Saiz">Albert Saiz</name><affiliation wicri:level="3"><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Bermel, Robert" sort="Bermel, Robert" uniqKey="Bermel R" first="Robert" last="Bermel">Robert Bermel</name><affiliation wicri:level="2"><nlm:affiliation>Cleveland Clinic Foundation, Cleveland, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cleveland Clinic Foundation, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Klistorner, Alexander" sort="Klistorner, Alexander" uniqKey="Klistorner A" first="Alexander" last="Klistorner">Alexander Klistorner</name><affiliation wicri:level="4"><nlm:affiliation>Save Sight Institute, University of Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Save Sight Institute, University of Sydney, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Petzold, Axel" sort="Petzold, Axel" uniqKey="Petzold A" first="Axel" last="Petzold">Axel Petzold</name><affiliation wicri:level="3"><nlm:affiliation>VU Medical Center, Amsterdam, Netherlands; Moorfields Eye Hospital, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>VU Medical Center, Amsterdam, Netherlands; Moorfields Eye Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Schippling, Sven" sort="Schippling, Sven" uniqKey="Schippling S" first="Sven" last="Schippling">Sven Schippling</name><affiliation wicri:level="4"><nlm:affiliation>University of Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>University of Zurich, Zurich</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Costello, Fiona" sort="Costello, Fiona" uniqKey="Costello F" first="Fiona" last="Costello">Fiona Costello</name><affiliation wicri:level="4"><nlm:affiliation>University of Calgary, Calgary, AB, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of Calgary, Calgary, AB</wicri:regionArea><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation></author><author><name sortKey="Aktas, Orhan" sort="Aktas, Orhan" uniqKey="Aktas O" first="Orhan" last="Aktas">Orhan Aktas</name><affiliation wicri:level="3"><nlm:affiliation>University of Düsseldorf, Düsseldorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Düsseldorf, Düsseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Vermersch, Patrick" sort="Vermersch, Patrick" uniqKey="Vermersch P" first="Patrick" last="Vermersch">Patrick Vermersch</name><affiliation wicri:level="3"><nlm:affiliation>University of Lille, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Oreja Guevara, Celia" sort="Oreja Guevara, Celia" uniqKey="Oreja Guevara C" first="Celia" last="Oreja-Guevara">Celia Oreja-Guevara</name><affiliation wicri:level="3"><nlm:affiliation>Hospital Clinico San Carlos, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Clinico San Carlos, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Comi, Giancarlo" sort="Comi, Giancarlo" uniqKey="Comi G" first="Giancarlo" last="Comi">Giancarlo Comi</name><affiliation wicri:level="3"><nlm:affiliation>San Raffaele Hospital, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>San Raffaele Hospital, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Leocani, Letizia" sort="Leocani, Letizia" uniqKey="Leocani L" first="Letizia" last="Leocani">Letizia Leocani</name><affiliation wicri:level="3"><nlm:affiliation>San Raffaele Hospital, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>San Raffaele Hospital, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Garcia Martin, Elena" sort="Garcia Martin, Elena" uniqKey="Garcia Martin E" first="Elena" last="Garcia-Martin">Elena Garcia-Martin</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Miguel Servet, Zaragoza, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Miguel Servet, Zaragoza</wicri:regionArea><wicri:noRegion>Zaragoza</wicri:noRegion></affiliation></author><author><name sortKey="Paul, Friedemann" sort="Paul, Friedemann" uniqKey="Paul F" first="Friedemann" last="Paul">Friedemann Paul</name><affiliation wicri:level="3"><nlm:affiliation>Experimental and Clinical Research Center and NeuroCure Clinical Research Center, Charité University Medicine and Max Delbrueck Center for Molecular Medicine, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Experimental and Clinical Research Center and NeuroCure Clinical Research Center, Charité University Medicine and Max Delbrueck Center for Molecular Medicine, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Havrdova, Eva" sort="Havrdova, Eva" uniqKey="Havrdova E" first="Eva" last="Havrdova">Eva Havrdova</name><affiliation wicri:level="3"><nlm:affiliation>Charles University, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Charles University, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Frohman, Elliot" sort="Frohman, Elliot" uniqKey="Frohman E" first="Elliot" last="Frohman">Elliot Frohman</name><affiliation wicri:level="2"><nlm:affiliation>University of Texas Southwestern Medical Center, Dallas, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Texas Southwestern Medical Center, Dallas, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Balcer, Laura J" sort="Balcer, Laura J" uniqKey="Balcer L" first="Laura J" last="Balcer">Laura J. Balcer</name><affiliation wicri:level="2"><nlm:affiliation>University of Pennsylvania, Philadelphia, PA, USA; New York University, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pennsylvania, Philadelphia, PA, USA; New York University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Green, Ari J" sort="Green, Ari J" uniqKey="Green A" first="Ari J" last="Green">Ari J. Green</name><affiliation wicri:level="2"><nlm:affiliation>University of California, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of California, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Calabresi, Peter A" sort="Calabresi, Peter A" uniqKey="Calabresi P" first="Peter A" last="Calabresi">Peter A. Calabresi</name><affiliation wicri:level="2"><nlm:affiliation>Johns Hopkins University, Baltimore, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins University, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Villoslada, Pablo" sort="Villoslada, Pablo" uniqKey="Villoslada P" first="Pablo" last="Villoslada">Pablo Villoslada</name><affiliation wicri:level="2"><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain; University of California, San Francisco, CA, USA. Electronic address: pvilloslada@clinic.ub.es.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain; University of California, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">The Lancet. Neurology</title><idno type="eISSN">1474-4465</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Cohort Studies</term><term>Disease Progression</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Macula Lutea (diagnostic imaging)</term><term>Male</term><term>Middle Aged</term><term>Multiple Sclerosis (complications)</term><term>Multiple Sclerosis (physiopathology)</term><term>Prognosis</term><term>Retinal Diseases (diagnostic imaging)</term><term>Retinal Diseases (etiology)</term><term>Retinal Neurons (pathology)</term><term>Severity of Illness Index</term><term>Tomography, Optical Coherence (methods)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Indice de gravité médicale</term><term>Macula (imagerie diagnostique)</term><term>Mâle</term><term>Neurones rétiniens (anatomopathologie)</term><term>Pronostic</term><term>Rétinopathies (imagerie diagnostique)</term><term>Rétinopathies (étiologie)</term><term>Sclérose en plaques ()</term><term>Sclérose en plaques (physiopathologie)</term><term>Tomographie par cohérence optique ()</term><term>Études de cohortes</term><term>Études de suivi</term><term>Évolution de la maladie</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Neurones rétiniens</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Multiple Sclerosis</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Macula Lutea</term><term>Retinal Diseases</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Retinal Diseases</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Macula</term><term>Rétinopathies</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Tomography, Optical Coherence</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Retinal Neurons</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Sclérose en plaques</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Multiple Sclerosis</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Rétinopathies</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Cohort Studies</term><term>Disease Progression</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prognosis</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Indice de gravité médicale</term><term>Mâle</term><term>Pronostic</term><term>Sclérose en plaques</term><term>Tomographie par cohérence optique</term><term>Études de cohortes</term><term>Études de suivi</term><term>Évolution de la maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Most patients with multiple sclerosis without previous optic neuritis have thinner retinal layers than healthy controls. We assessed the role of peripapillary retinal nerve fibre layer (pRNFL) thickness and macular volume in eyes with no history of optic neuritis as a biomarker of disability worsening in a cohort of patients with multiple sclerosis who had at least one eye without optic neuritis available.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27011339</PMID><DateCreated><Year>2016</Year><Month>06</Month><Day>15</Day></DateCreated><DateCompleted><Year>2017</Year><Month>05</Month><Day>29</Day></DateCompleted><DateRevised><Year>2017</Year><Month>05</Month><Day>29</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1474-4465</ISSN><JournalIssue CitedMedium="Internet"><Volume>15</Volume><Issue>6</Issue><PubDate><Year>2016</Year><Month>May</Month></PubDate></JournalIssue><Title>The Lancet. Neurology</Title><ISOAbbreviation>Lancet Neurol</ISOAbbreviation></Journal><ArticleTitle>Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study.</ArticleTitle><Pagination><MedlinePgn>574-84</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/S1474-4422(16)00068-5</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1474-4422(16)00068-5</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Most patients with multiple sclerosis without previous optic neuritis have thinner retinal layers than healthy controls. We assessed the role of peripapillary retinal nerve fibre layer (pRNFL) thickness and macular volume in eyes with no history of optic neuritis as a biomarker of disability worsening in a cohort of patients with multiple sclerosis who had at least one eye without optic neuritis available.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">In this multicentre, cohort study, we collected data about patients (age ≥16 years old) with clinically isolated syndrome, relapsing-remitting multiple sclerosis, and progressive multiple sclerosis. Patients were recruited from centres in Spain, Italy, France, Germany, Czech Republic, Netherlands, Canada, and the USA, with the first cohort starting in 2008 and the latest cohort starting in 2013. We assessed disability worsening using the Expanded Disability Status Scale (EDSS). The pRNFL thickness and macular volume were assessed once at study entry (baseline) by optical coherence tomography (OCT) and was calculated as the mean value of both eyes without optic neuritis for patients without a history of optic neuritis or the value of the non-optic neuritis eye for patients with previous unilateral optic neuritis. Researchers who did the OCT at baseline were masked to EDSS results and the researchers assessing disability with EDSS were masked to OCT results. We estimated the association of pRNFL thickness or macular volume at baseline in eyes without optic neuritis with the risk of subsequent disability worsening by use of proportional hazards models that included OCT metrics and age, disease duration, disability, presence of previous unilateral optic neuritis, and use of disease-modifying therapies as covariates.</AbstractText><AbstractText Label="FINDINGS" NlmCategory="RESULTS">879 patients with clinically isolated syndrome (n=74), relapsing-remitting multiple sclerosis (n=664), or progressive multiple sclerosis (n=141) were included in the primary analyses. Disability worsening occurred in 252 (29%) of 879 patients with multiple sclerosis after a median follow-up of 2·0 years (range 0·5-5 years). Patients with a pRNFL of less than or equal to 87 μm or less than or equal to 88 μm (measured with Spectralis or Cirrus OCT devices) had double the risk of disability worsening at any time after the first and up to the third years of follow-up (hazard ratio 2·06, 95% CI 1·36-3·11; p=0·001), and the risk was increased by nearly four times after the third and up to the fifth years of follow-up (3·81, 1·63-8·91; p=0·002). We did not identify meaningful associations for macular volume.</AbstractText><AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">Our results provide evidence of the usefulness of monitoring pRNFL thickness by OCT for prediction of the risk of disability worsening with time in patients with multiple sclerosis.</AbstractText><AbstractText Label="FUNDING" NlmCategory="BACKGROUND">Instituto de Salud Carlos III.</AbstractText><CopyrightInformation>Copyright © 2016 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Martinez-Lapiscina</LastName><ForeName>Elena H</ForeName><Initials>EH</Initials><AffiliationInfo><Affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arnow</LastName><ForeName>Sam</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>University of California, San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wilson</LastName><ForeName>James A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>University of Pennsylvania, Philadelphia, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saidha</LastName><ForeName>Shiv</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Johns Hopkins University, Baltimore, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Preiningerova</LastName><ForeName>Jana Lizrova</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Charles University, Prague, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oberwahrenbrock</LastName><ForeName>Timm</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Experimental and Clinical Research Center and NeuroCure Clinical Research Center, Charité University Medicine and Max Delbrueck Center for Molecular Medicine, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brandt</LastName><ForeName>Alexander U</ForeName><Initials>AU</Initials><AffiliationInfo><Affiliation>Experimental and Clinical Research Center and NeuroCure Clinical Research Center, Charité University Medicine and Max Delbrueck Center for Molecular Medicine, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pablo</LastName><ForeName>Luis E</ForeName><Initials>LE</Initials><AffiliationInfo><Affiliation>Hospital Miguel Servet, Zaragoza, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guerrieri</LastName><ForeName>Simone</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>San Raffaele Hospital, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gonzalez</LastName><ForeName>Ines</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Hospital Clinico San Carlos, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Outteryck</LastName><ForeName>Olivier</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>University of Lille, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mueller</LastName><ForeName>Ann-Kristin</ForeName><Initials>AK</Initials><AffiliationInfo><Affiliation>University of Düsseldorf, Düsseldorf, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Albrecht</LastName><ForeName>Phillip</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>University of Düsseldorf, Düsseldorf, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chan</LastName><ForeName>Wesley</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>University of Calgary, Calgary, AB, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lukas</LastName><ForeName>Sebastian</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>University of Zurich, Zurich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Balk</LastName><ForeName>Lisanne J</ForeName><Initials>LJ</Initials><AffiliationInfo><Affiliation>VU Medical Center, Amsterdam, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fraser</LastName><ForeName>Clare</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Save Sight Institute, University of Sydney, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Frederiksen</LastName><ForeName>Jette L</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Glostrup Hospital, University of Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Resto</LastName><ForeName>Jennifer</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Cleveland Clinic Foundation, Cleveland, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Frohman</LastName><ForeName>Teresa</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>University of Texas Southwestern Medical Center, Dallas, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cordano</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>University of California, San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zubizarreta</LastName><ForeName>Irati</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Andorra</LastName><ForeName>Magi</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sanchez-Dalmau</LastName><ForeName>Bernardo</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saiz</LastName><ForeName>Albert</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bermel</LastName><ForeName>Robert</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Cleveland Clinic Foundation, Cleveland, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Klistorner</LastName><ForeName>Alexander</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Save Sight Institute, University of Sydney, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Petzold</LastName><ForeName>Axel</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>VU Medical Center, Amsterdam, Netherlands; Moorfields Eye Hospital, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schippling</LastName><ForeName>Sven</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>University of Zurich, Zurich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Costello</LastName><ForeName>Fiona</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>University of Calgary, Calgary, AB, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aktas</LastName><ForeName>Orhan</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>University of Düsseldorf, Düsseldorf, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vermersch</LastName><ForeName>Patrick</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>University of Lille, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oreja-Guevara</LastName><ForeName>Celia</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Hospital Clinico San Carlos, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Comi</LastName><ForeName>Giancarlo</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>San Raffaele Hospital, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leocani</LastName><ForeName>Letizia</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>San Raffaele Hospital, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Garcia-Martin</LastName><ForeName>Elena</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Hospital Miguel Servet, Zaragoza, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Paul</LastName><ForeName>Friedemann</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Experimental and Clinical Research Center and NeuroCure Clinical Research Center, Charité University Medicine and Max Delbrueck Center for Molecular Medicine, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Havrdova</LastName><ForeName>Eva</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Charles University, Prague, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Frohman</LastName><ForeName>Elliot</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>University of Texas Southwestern Medical Center, Dallas, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Balcer</LastName><ForeName>Laura J</ForeName><Initials>LJ</Initials><AffiliationInfo><Affiliation>University of Pennsylvania, Philadelphia, PA, USA; New York University, New York, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Green</LastName><ForeName>Ari J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>University of California, San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Calabresi</LastName><ForeName>Peter A</ForeName><Initials>PA</Initials><AffiliationInfo><Affiliation>Johns Hopkins University, Baltimore, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Villoslada</LastName><ForeName>Pablo</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain; University of California, San Francisco, CA, USA. Electronic address: pvilloslada@clinic.ub.es.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>IMSVISUAL consortium</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>03</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Lancet Neurol</MedlineTA><NlmUniqueID>101139309</NlmUniqueID><ISSNLinking>1474-4422</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018450" MajorTopicYN="Y">Disease Progression</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008266" MajorTopicYN="N">Macula Lutea</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009103" MajorTopicYN="N">Multiple Sclerosis</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012164" MajorTopicYN="N">Retinal Diseases</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055351" MajorTopicYN="N">Retinal Neurons</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D041623" MajorTopicYN="N">Tomography, Optical Coherence</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>11</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>02</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>02</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>3</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>3</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>5</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27011339</ArticleId><ArticleId IdType="pii">S1474-4422(16)00068-5</ArticleId><ArticleId IdType="doi">10.1016/S1474-4422(16)00068-5</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Danemark</li><li>Espagne</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>République tchèque</li><li>Suisse</li><li>États-Unis</li></country><region><li>Alberta</li><li>Angleterre</li><li>Berlin</li><li>Bohême centrale</li><li>Californie</li><li>Canton de Zurich</li><li>Catalogne</li><li>Communauté de Madrid</li><li>District de Düsseldorf</li><li>Grand Londres</li><li>Hauts-de-France</li><li>Hollande-Septentrionale</li><li>Lombardie</li><li>Maryland</li><li>Nord-Pas-de-Calais</li><li>Nouvelle-Galles du Sud</li><li>Ohio</li><li>Pennsylvanie</li><li>Rhénanie-du-Nord-Westphalie</li><li>Texas</li><li>État de New York</li></region><settlement><li>Amsterdam</li><li>Barcelone</li><li>Berlin</li><li>Calgary</li><li>Düsseldorf</li><li>Lille</li><li>Londres</li><li>Madrid</li><li>Milan</li><li>Prague</li><li>Sydney</li><li>Zurich</li></settlement><orgName><li>Université de Calgary</li><li>Université de Sydney</li><li>Université de Zurich</li></orgName></list><tree><country name="Espagne"><region name="Catalogne"><name sortKey="Martinez Lapiscina, Elena H" sort="Martinez Lapiscina, Elena H" uniqKey="Martinez Lapiscina E" first="Elena H" last="Martinez-Lapiscina">Elena H. Martinez-Lapiscina</name></region><name sortKey="Andorra, Magi" sort="Andorra, Magi" uniqKey="Andorra M" first="Magi" last="Andorra">Magi Andorra</name><name sortKey="Garcia Martin, Elena" sort="Garcia Martin, Elena" uniqKey="Garcia Martin E" first="Elena" last="Garcia-Martin">Elena Garcia-Martin</name><name sortKey="Gonzalez, Ines" sort="Gonzalez, Ines" uniqKey="Gonzalez I" first="Ines" last="Gonzalez">Ines Gonzalez</name><name sortKey="Oreja Guevara, Celia" sort="Oreja Guevara, Celia" uniqKey="Oreja Guevara C" first="Celia" last="Oreja-Guevara">Celia Oreja-Guevara</name><name sortKey="Pablo, Luis E" sort="Pablo, Luis E" uniqKey="Pablo L" first="Luis E" last="Pablo">Luis E. Pablo</name><name sortKey="Saiz, Albert" sort="Saiz, Albert" uniqKey="Saiz A" first="Albert" last="Saiz">Albert Saiz</name><name sortKey="Sanchez Dalmau, Bernardo" sort="Sanchez Dalmau, Bernardo" uniqKey="Sanchez Dalmau B" first="Bernardo" last="Sanchez-Dalmau">Bernardo Sanchez-Dalmau</name><name sortKey="Zubizarreta, Irati" sort="Zubizarreta, Irati" uniqKey="Zubizarreta I" first="Irati" last="Zubizarreta">Irati Zubizarreta</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Arnow, Sam" sort="Arnow, Sam" uniqKey="Arnow S" first="Sam" last="Arnow">Sam Arnow</name></region><name sortKey="Balcer, Laura J" sort="Balcer, Laura J" uniqKey="Balcer L" first="Laura J" last="Balcer">Laura J. Balcer</name><name sortKey="Bermel, Robert" sort="Bermel, Robert" uniqKey="Bermel R" first="Robert" last="Bermel">Robert Bermel</name><name sortKey="Calabresi, Peter A" sort="Calabresi, Peter A" uniqKey="Calabresi P" first="Peter A" last="Calabresi">Peter A. Calabresi</name><name sortKey="Cordano, Christian" sort="Cordano, Christian" uniqKey="Cordano C" first="Christian" last="Cordano">Christian Cordano</name><name sortKey="Frohman, Elliot" sort="Frohman, Elliot" uniqKey="Frohman E" first="Elliot" last="Frohman">Elliot Frohman</name><name sortKey="Frohman, Teresa" sort="Frohman, Teresa" uniqKey="Frohman T" first="Teresa" last="Frohman">Teresa Frohman</name><name sortKey="Green, Ari J" sort="Green, Ari J" uniqKey="Green A" first="Ari J" last="Green">Ari J. Green</name><name sortKey="Resto, Jennifer" sort="Resto, Jennifer" uniqKey="Resto J" first="Jennifer" last="Resto">Jennifer Resto</name><name sortKey="Saidha, Shiv" sort="Saidha, Shiv" uniqKey="Saidha S" first="Shiv" last="Saidha">Shiv Saidha</name><name sortKey="Villoslada, Pablo" sort="Villoslada, Pablo" uniqKey="Villoslada P" first="Pablo" last="Villoslada">Pablo Villoslada</name><name sortKey="Wilson, James A" sort="Wilson, James A" uniqKey="Wilson J" first="James A" last="Wilson">James A. Wilson</name></country><country name="République tchèque"><region name="Bohême centrale"><name sortKey="Preiningerova, Jana Lizrova" sort="Preiningerova, Jana Lizrova" uniqKey="Preiningerova J" first="Jana Lizrova" last="Preiningerova">Jana Lizrova Preiningerova</name></region><name sortKey="Havrdova, Eva" sort="Havrdova, Eva" uniqKey="Havrdova E" first="Eva" last="Havrdova">Eva Havrdova</name></country><country name="Allemagne"><region name="Berlin"><name sortKey="Oberwahrenbrock, Timm" sort="Oberwahrenbrock, Timm" uniqKey="Oberwahrenbrock T" first="Timm" last="Oberwahrenbrock">Timm Oberwahrenbrock</name></region><name sortKey="Aktas, Orhan" sort="Aktas, Orhan" uniqKey="Aktas O" first="Orhan" last="Aktas">Orhan Aktas</name><name sortKey="Albrecht, Phillip" sort="Albrecht, Phillip" uniqKey="Albrecht P" first="Phillip" last="Albrecht">Phillip Albrecht</name><name sortKey="Brandt, Alexander U" sort="Brandt, Alexander U" uniqKey="Brandt A" first="Alexander U" last="Brandt">Alexander U. Brandt</name><name sortKey="Mueller, Ann Kristin" sort="Mueller, Ann Kristin" uniqKey="Mueller A" first="Ann-Kristin" last="Mueller">Ann-Kristin Mueller</name><name sortKey="Paul, Friedemann" sort="Paul, Friedemann" uniqKey="Paul F" first="Friedemann" last="Paul">Friedemann Paul</name></country><country name="Italie"><region name="Lombardie"><name sortKey="Guerrieri, Simone" sort="Guerrieri, Simone" uniqKey="Guerrieri S" first="Simone" last="Guerrieri">Simone Guerrieri</name></region><name sortKey="Comi, Giancarlo" sort="Comi, Giancarlo" uniqKey="Comi G" first="Giancarlo" last="Comi">Giancarlo Comi</name><name sortKey="Leocani, Letizia" sort="Leocani, Letizia" uniqKey="Leocani L" first="Letizia" last="Leocani">Letizia Leocani</name></country><country name="France"><region name="Hauts-de-France"><name sortKey="Outteryck, Olivier" sort="Outteryck, Olivier" uniqKey="Outteryck O" first="Olivier" last="Outteryck">Olivier Outteryck</name></region><name sortKey="Vermersch, Patrick" sort="Vermersch, Patrick" uniqKey="Vermersch P" first="Patrick" last="Vermersch">Patrick Vermersch</name></country><country name="Canada"><region name="Alberta"><name sortKey="Chan, Wesley" sort="Chan, Wesley" uniqKey="Chan W" first="Wesley" last="Chan">Wesley Chan</name></region><name sortKey="Costello, Fiona" sort="Costello, Fiona" uniqKey="Costello F" first="Fiona" last="Costello">Fiona Costello</name></country><country name="Suisse"><region name="Canton de Zurich"><name sortKey="Lukas, Sebastian" sort="Lukas, Sebastian" uniqKey="Lukas S" first="Sebastian" last="Lukas">Sebastian Lukas</name></region><name sortKey="Schippling, Sven" sort="Schippling, Sven" uniqKey="Schippling S" first="Sven" last="Schippling">Sven Schippling</name></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Balk, Lisanne J" sort="Balk, Lisanne J" uniqKey="Balk L" first="Lisanne J" last="Balk">Lisanne J. Balk</name></region></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Fraser, Clare" sort="Fraser, Clare" uniqKey="Fraser C" first="Clare" last="Fraser">Clare Fraser</name></region><name sortKey="Klistorner, Alexander" sort="Klistorner, Alexander" uniqKey="Klistorner A" first="Alexander" last="Klistorner">Alexander Klistorner</name></country><country name="Danemark"><noRegion><name sortKey="Frederiksen, Jette L" sort="Frederiksen, Jette L" uniqKey="Frederiksen J" first="Jette L" last="Frederiksen">Jette L. Frederiksen</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Petzold, Axel" sort="Petzold, Axel" uniqKey="Petzold A" first="Axel" last="Petzold">Axel Petzold</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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