Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study.
Identifieur interne : 001F41 ( PubMed/Corpus ); précédent : 001F40; suivant : 001F42Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study.
Auteurs : Elena H. Martinez-Lapiscina ; Sam Arnow ; James A. Wilson ; Shiv Saidha ; Jana Lizrova Preiningerova ; Timm Oberwahrenbrock ; Alexander U. Brandt ; Luis E. Pablo ; Simone Guerrieri ; Ines Gonzalez ; Olivier Outteryck ; Ann-Kristin Mueller ; Phillip Albrecht ; Wesley Chan ; Sebastian Lukas ; Lisanne J. Balk ; Clare Fraser ; Jette L. Frederiksen ; Jennifer Resto ; Teresa Frohman ; Christian Cordano ; Irati Zubizarreta ; Magi Andorra ; Bernardo Sanchez-Dalmau ; Albert Saiz ; Robert Bermel ; Alexander Klistorner ; Axel Petzold ; Sven Schippling ; Fiona Costello ; Orhan Aktas ; Patrick Vermersch ; Celia Oreja-Guevara ; Giancarlo Comi ; Letizia Leocani ; Elena Garcia-Martin ; Friedemann Paul ; Eva Havrdova ; Elliot Frohman ; Laura J. Balcer ; Ari J. Green ; Peter A. Calabresi ; Pablo VillosladaSource :
- The Lancet. Neurology [ 1474-4465 ] ; 2016.
English descriptors
- KwdEn :
- Adult, Cohort Studies, Disease Progression, Female, Follow-Up Studies, Humans, Macula Lutea (diagnostic imaging), Male, Middle Aged, Multiple Sclerosis (complications), Multiple Sclerosis (physiopathology), Prognosis, Retinal Diseases (diagnostic imaging), Retinal Diseases (etiology), Retinal Neurons (pathology), Severity of Illness Index, Tomography, Optical Coherence (methods).
- MESH :
- complications : Multiple Sclerosis.
- diagnostic imaging : Macula Lutea, Retinal Diseases.
- etiology : Retinal Diseases.
- methods : Tomography, Optical Coherence.
- pathology : Retinal Neurons.
- physiopathology : Multiple Sclerosis.
- Adult, Cohort Studies, Disease Progression, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prognosis, Severity of Illness Index.
Abstract
Most patients with multiple sclerosis without previous optic neuritis have thinner retinal layers than healthy controls. We assessed the role of peripapillary retinal nerve fibre layer (pRNFL) thickness and macular volume in eyes with no history of optic neuritis as a biomarker of disability worsening in a cohort of patients with multiple sclerosis who had at least one eye without optic neuritis available.
DOI: 10.1016/S1474-4422(16)00068-5
PubMed: 27011339
Links to Exploration step
pubmed:27011339Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study.</title>
<author><name sortKey="Martinez Lapiscina, Elena H" sort="Martinez Lapiscina, Elena H" uniqKey="Martinez Lapiscina E" first="Elena H" last="Martinez-Lapiscina">Elena H. Martinez-Lapiscina</name>
<affiliation><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Arnow, Sam" sort="Arnow, Sam" uniqKey="Arnow S" first="Sam" last="Arnow">Sam Arnow</name>
<affiliation><nlm:affiliation>University of California, San Francisco, CA, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wilson, James A" sort="Wilson, James A" uniqKey="Wilson J" first="James A" last="Wilson">James A. Wilson</name>
<affiliation><nlm:affiliation>University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Saidha, Shiv" sort="Saidha, Shiv" uniqKey="Saidha S" first="Shiv" last="Saidha">Shiv Saidha</name>
<affiliation><nlm:affiliation>Johns Hopkins University, Baltimore, MD, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Preiningerova, Jana Lizrova" sort="Preiningerova, Jana Lizrova" uniqKey="Preiningerova J" first="Jana Lizrova" last="Preiningerova">Jana Lizrova Preiningerova</name>
<affiliation><nlm:affiliation>Charles University, Prague, Czech Republic.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Oberwahrenbrock, Timm" sort="Oberwahrenbrock, Timm" uniqKey="Oberwahrenbrock T" first="Timm" last="Oberwahrenbrock">Timm Oberwahrenbrock</name>
<affiliation><nlm:affiliation>Experimental and Clinical Research Center and NeuroCure Clinical Research Center, Charité University Medicine and Max Delbrueck Center for Molecular Medicine, Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Brandt, Alexander U" sort="Brandt, Alexander U" uniqKey="Brandt A" first="Alexander U" last="Brandt">Alexander U. Brandt</name>
<affiliation><nlm:affiliation>Experimental and Clinical Research Center and NeuroCure Clinical Research Center, Charité University Medicine and Max Delbrueck Center for Molecular Medicine, Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pablo, Luis E" sort="Pablo, Luis E" uniqKey="Pablo L" first="Luis E" last="Pablo">Luis E. Pablo</name>
<affiliation><nlm:affiliation>Hospital Miguel Servet, Zaragoza, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Guerrieri, Simone" sort="Guerrieri, Simone" uniqKey="Guerrieri S" first="Simone" last="Guerrieri">Simone Guerrieri</name>
<affiliation><nlm:affiliation>San Raffaele Hospital, Milan, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gonzalez, Ines" sort="Gonzalez, Ines" uniqKey="Gonzalez I" first="Ines" last="Gonzalez">Ines Gonzalez</name>
<affiliation><nlm:affiliation>Hospital Clinico San Carlos, Madrid, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Outteryck, Olivier" sort="Outteryck, Olivier" uniqKey="Outteryck O" first="Olivier" last="Outteryck">Olivier Outteryck</name>
<affiliation><nlm:affiliation>University of Lille, Lille, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mueller, Ann Kristin" sort="Mueller, Ann Kristin" uniqKey="Mueller A" first="Ann-Kristin" last="Mueller">Ann-Kristin Mueller</name>
<affiliation><nlm:affiliation>University of Düsseldorf, Düsseldorf, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Albrecht, Phillip" sort="Albrecht, Phillip" uniqKey="Albrecht P" first="Phillip" last="Albrecht">Phillip Albrecht</name>
<affiliation><nlm:affiliation>University of Düsseldorf, Düsseldorf, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chan, Wesley" sort="Chan, Wesley" uniqKey="Chan W" first="Wesley" last="Chan">Wesley Chan</name>
<affiliation><nlm:affiliation>University of Calgary, Calgary, AB, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lukas, Sebastian" sort="Lukas, Sebastian" uniqKey="Lukas S" first="Sebastian" last="Lukas">Sebastian Lukas</name>
<affiliation><nlm:affiliation>University of Zurich, Zurich, Switzerland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Balk, Lisanne J" sort="Balk, Lisanne J" uniqKey="Balk L" first="Lisanne J" last="Balk">Lisanne J. Balk</name>
<affiliation><nlm:affiliation>VU Medical Center, Amsterdam, Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Fraser, Clare" sort="Fraser, Clare" uniqKey="Fraser C" first="Clare" last="Fraser">Clare Fraser</name>
<affiliation><nlm:affiliation>Save Sight Institute, University of Sydney, NSW, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Frederiksen, Jette L" sort="Frederiksen, Jette L" uniqKey="Frederiksen J" first="Jette L" last="Frederiksen">Jette L. Frederiksen</name>
<affiliation><nlm:affiliation>Glostrup Hospital, University of Copenhagen, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Resto, Jennifer" sort="Resto, Jennifer" uniqKey="Resto J" first="Jennifer" last="Resto">Jennifer Resto</name>
<affiliation><nlm:affiliation>Cleveland Clinic Foundation, Cleveland, OH, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Frohman, Teresa" sort="Frohman, Teresa" uniqKey="Frohman T" first="Teresa" last="Frohman">Teresa Frohman</name>
<affiliation><nlm:affiliation>University of Texas Southwestern Medical Center, Dallas, TX, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cordano, Christian" sort="Cordano, Christian" uniqKey="Cordano C" first="Christian" last="Cordano">Christian Cordano</name>
<affiliation><nlm:affiliation>University of California, San Francisco, CA, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Zubizarreta, Irati" sort="Zubizarreta, Irati" uniqKey="Zubizarreta I" first="Irati" last="Zubizarreta">Irati Zubizarreta</name>
<affiliation><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Andorra, Magi" sort="Andorra, Magi" uniqKey="Andorra M" first="Magi" last="Andorra">Magi Andorra</name>
<affiliation><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sanchez Dalmau, Bernardo" sort="Sanchez Dalmau, Bernardo" uniqKey="Sanchez Dalmau B" first="Bernardo" last="Sanchez-Dalmau">Bernardo Sanchez-Dalmau</name>
<affiliation><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Saiz, Albert" sort="Saiz, Albert" uniqKey="Saiz A" first="Albert" last="Saiz">Albert Saiz</name>
<affiliation><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bermel, Robert" sort="Bermel, Robert" uniqKey="Bermel R" first="Robert" last="Bermel">Robert Bermel</name>
<affiliation><nlm:affiliation>Cleveland Clinic Foundation, Cleveland, OH, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Klistorner, Alexander" sort="Klistorner, Alexander" uniqKey="Klistorner A" first="Alexander" last="Klistorner">Alexander Klistorner</name>
<affiliation><nlm:affiliation>Save Sight Institute, University of Sydney, NSW, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Petzold, Axel" sort="Petzold, Axel" uniqKey="Petzold A" first="Axel" last="Petzold">Axel Petzold</name>
<affiliation><nlm:affiliation>VU Medical Center, Amsterdam, Netherlands; Moorfields Eye Hospital, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Schippling, Sven" sort="Schippling, Sven" uniqKey="Schippling S" first="Sven" last="Schippling">Sven Schippling</name>
<affiliation><nlm:affiliation>University of Zurich, Zurich, Switzerland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Costello, Fiona" sort="Costello, Fiona" uniqKey="Costello F" first="Fiona" last="Costello">Fiona Costello</name>
<affiliation><nlm:affiliation>University of Calgary, Calgary, AB, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Aktas, Orhan" sort="Aktas, Orhan" uniqKey="Aktas O" first="Orhan" last="Aktas">Orhan Aktas</name>
<affiliation><nlm:affiliation>University of Düsseldorf, Düsseldorf, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Vermersch, Patrick" sort="Vermersch, Patrick" uniqKey="Vermersch P" first="Patrick" last="Vermersch">Patrick Vermersch</name>
<affiliation><nlm:affiliation>University of Lille, Lille, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Oreja Guevara, Celia" sort="Oreja Guevara, Celia" uniqKey="Oreja Guevara C" first="Celia" last="Oreja-Guevara">Celia Oreja-Guevara</name>
<affiliation><nlm:affiliation>Hospital Clinico San Carlos, Madrid, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Comi, Giancarlo" sort="Comi, Giancarlo" uniqKey="Comi G" first="Giancarlo" last="Comi">Giancarlo Comi</name>
<affiliation><nlm:affiliation>San Raffaele Hospital, Milan, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Leocani, Letizia" sort="Leocani, Letizia" uniqKey="Leocani L" first="Letizia" last="Leocani">Letizia Leocani</name>
<affiliation><nlm:affiliation>San Raffaele Hospital, Milan, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Garcia Martin, Elena" sort="Garcia Martin, Elena" uniqKey="Garcia Martin E" first="Elena" last="Garcia-Martin">Elena Garcia-Martin</name>
<affiliation><nlm:affiliation>Hospital Miguel Servet, Zaragoza, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Paul, Friedemann" sort="Paul, Friedemann" uniqKey="Paul F" first="Friedemann" last="Paul">Friedemann Paul</name>
<affiliation><nlm:affiliation>Experimental and Clinical Research Center and NeuroCure Clinical Research Center, Charité University Medicine and Max Delbrueck Center for Molecular Medicine, Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Havrdova, Eva" sort="Havrdova, Eva" uniqKey="Havrdova E" first="Eva" last="Havrdova">Eva Havrdova</name>
<affiliation><nlm:affiliation>Charles University, Prague, Czech Republic.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Frohman, Elliot" sort="Frohman, Elliot" uniqKey="Frohman E" first="Elliot" last="Frohman">Elliot Frohman</name>
<affiliation><nlm:affiliation>University of Texas Southwestern Medical Center, Dallas, TX, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Balcer, Laura J" sort="Balcer, Laura J" uniqKey="Balcer L" first="Laura J" last="Balcer">Laura J. Balcer</name>
<affiliation><nlm:affiliation>University of Pennsylvania, Philadelphia, PA, USA; New York University, New York, NY, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Green, Ari J" sort="Green, Ari J" uniqKey="Green A" first="Ari J" last="Green">Ari J. Green</name>
<affiliation><nlm:affiliation>University of California, San Francisco, CA, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Calabresi, Peter A" sort="Calabresi, Peter A" uniqKey="Calabresi P" first="Peter A" last="Calabresi">Peter A. Calabresi</name>
<affiliation><nlm:affiliation>Johns Hopkins University, Baltimore, MD, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Villoslada, Pablo" sort="Villoslada, Pablo" uniqKey="Villoslada P" first="Pablo" last="Villoslada">Pablo Villoslada</name>
<affiliation><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain; University of California, San Francisco, CA, USA. Electronic address: pvilloslada@clinic.ub.es.</nlm:affiliation>
</affiliation>
</author>
</titleStmt>
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<date when="2016">2016</date>
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<idno type="pmid">27011339</idno>
<idno type="doi">10.1016/S1474-4422(16)00068-5</idno>
<idno type="wicri:Area/PubMed/Corpus">001F41</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study.</title>
<author><name sortKey="Martinez Lapiscina, Elena H" sort="Martinez Lapiscina, Elena H" uniqKey="Martinez Lapiscina E" first="Elena H" last="Martinez-Lapiscina">Elena H. Martinez-Lapiscina</name>
<affiliation><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Arnow, Sam" sort="Arnow, Sam" uniqKey="Arnow S" first="Sam" last="Arnow">Sam Arnow</name>
<affiliation><nlm:affiliation>University of California, San Francisco, CA, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wilson, James A" sort="Wilson, James A" uniqKey="Wilson J" first="James A" last="Wilson">James A. Wilson</name>
<affiliation><nlm:affiliation>University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Saidha, Shiv" sort="Saidha, Shiv" uniqKey="Saidha S" first="Shiv" last="Saidha">Shiv Saidha</name>
<affiliation><nlm:affiliation>Johns Hopkins University, Baltimore, MD, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Preiningerova, Jana Lizrova" sort="Preiningerova, Jana Lizrova" uniqKey="Preiningerova J" first="Jana Lizrova" last="Preiningerova">Jana Lizrova Preiningerova</name>
<affiliation><nlm:affiliation>Charles University, Prague, Czech Republic.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Oberwahrenbrock, Timm" sort="Oberwahrenbrock, Timm" uniqKey="Oberwahrenbrock T" first="Timm" last="Oberwahrenbrock">Timm Oberwahrenbrock</name>
<affiliation><nlm:affiliation>Experimental and Clinical Research Center and NeuroCure Clinical Research Center, Charité University Medicine and Max Delbrueck Center for Molecular Medicine, Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Brandt, Alexander U" sort="Brandt, Alexander U" uniqKey="Brandt A" first="Alexander U" last="Brandt">Alexander U. Brandt</name>
<affiliation><nlm:affiliation>Experimental and Clinical Research Center and NeuroCure Clinical Research Center, Charité University Medicine and Max Delbrueck Center for Molecular Medicine, Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pablo, Luis E" sort="Pablo, Luis E" uniqKey="Pablo L" first="Luis E" last="Pablo">Luis E. Pablo</name>
<affiliation><nlm:affiliation>Hospital Miguel Servet, Zaragoza, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Guerrieri, Simone" sort="Guerrieri, Simone" uniqKey="Guerrieri S" first="Simone" last="Guerrieri">Simone Guerrieri</name>
<affiliation><nlm:affiliation>San Raffaele Hospital, Milan, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gonzalez, Ines" sort="Gonzalez, Ines" uniqKey="Gonzalez I" first="Ines" last="Gonzalez">Ines Gonzalez</name>
<affiliation><nlm:affiliation>Hospital Clinico San Carlos, Madrid, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Outteryck, Olivier" sort="Outteryck, Olivier" uniqKey="Outteryck O" first="Olivier" last="Outteryck">Olivier Outteryck</name>
<affiliation><nlm:affiliation>University of Lille, Lille, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mueller, Ann Kristin" sort="Mueller, Ann Kristin" uniqKey="Mueller A" first="Ann-Kristin" last="Mueller">Ann-Kristin Mueller</name>
<affiliation><nlm:affiliation>University of Düsseldorf, Düsseldorf, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Albrecht, Phillip" sort="Albrecht, Phillip" uniqKey="Albrecht P" first="Phillip" last="Albrecht">Phillip Albrecht</name>
<affiliation><nlm:affiliation>University of Düsseldorf, Düsseldorf, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chan, Wesley" sort="Chan, Wesley" uniqKey="Chan W" first="Wesley" last="Chan">Wesley Chan</name>
<affiliation><nlm:affiliation>University of Calgary, Calgary, AB, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lukas, Sebastian" sort="Lukas, Sebastian" uniqKey="Lukas S" first="Sebastian" last="Lukas">Sebastian Lukas</name>
<affiliation><nlm:affiliation>University of Zurich, Zurich, Switzerland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Balk, Lisanne J" sort="Balk, Lisanne J" uniqKey="Balk L" first="Lisanne J" last="Balk">Lisanne J. Balk</name>
<affiliation><nlm:affiliation>VU Medical Center, Amsterdam, Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Fraser, Clare" sort="Fraser, Clare" uniqKey="Fraser C" first="Clare" last="Fraser">Clare Fraser</name>
<affiliation><nlm:affiliation>Save Sight Institute, University of Sydney, NSW, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Frederiksen, Jette L" sort="Frederiksen, Jette L" uniqKey="Frederiksen J" first="Jette L" last="Frederiksen">Jette L. Frederiksen</name>
<affiliation><nlm:affiliation>Glostrup Hospital, University of Copenhagen, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Resto, Jennifer" sort="Resto, Jennifer" uniqKey="Resto J" first="Jennifer" last="Resto">Jennifer Resto</name>
<affiliation><nlm:affiliation>Cleveland Clinic Foundation, Cleveland, OH, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Frohman, Teresa" sort="Frohman, Teresa" uniqKey="Frohman T" first="Teresa" last="Frohman">Teresa Frohman</name>
<affiliation><nlm:affiliation>University of Texas Southwestern Medical Center, Dallas, TX, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cordano, Christian" sort="Cordano, Christian" uniqKey="Cordano C" first="Christian" last="Cordano">Christian Cordano</name>
<affiliation><nlm:affiliation>University of California, San Francisco, CA, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Zubizarreta, Irati" sort="Zubizarreta, Irati" uniqKey="Zubizarreta I" first="Irati" last="Zubizarreta">Irati Zubizarreta</name>
<affiliation><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Andorra, Magi" sort="Andorra, Magi" uniqKey="Andorra M" first="Magi" last="Andorra">Magi Andorra</name>
<affiliation><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sanchez Dalmau, Bernardo" sort="Sanchez Dalmau, Bernardo" uniqKey="Sanchez Dalmau B" first="Bernardo" last="Sanchez-Dalmau">Bernardo Sanchez-Dalmau</name>
<affiliation><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Saiz, Albert" sort="Saiz, Albert" uniqKey="Saiz A" first="Albert" last="Saiz">Albert Saiz</name>
<affiliation><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bermel, Robert" sort="Bermel, Robert" uniqKey="Bermel R" first="Robert" last="Bermel">Robert Bermel</name>
<affiliation><nlm:affiliation>Cleveland Clinic Foundation, Cleveland, OH, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Klistorner, Alexander" sort="Klistorner, Alexander" uniqKey="Klistorner A" first="Alexander" last="Klistorner">Alexander Klistorner</name>
<affiliation><nlm:affiliation>Save Sight Institute, University of Sydney, NSW, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Petzold, Axel" sort="Petzold, Axel" uniqKey="Petzold A" first="Axel" last="Petzold">Axel Petzold</name>
<affiliation><nlm:affiliation>VU Medical Center, Amsterdam, Netherlands; Moorfields Eye Hospital, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Schippling, Sven" sort="Schippling, Sven" uniqKey="Schippling S" first="Sven" last="Schippling">Sven Schippling</name>
<affiliation><nlm:affiliation>University of Zurich, Zurich, Switzerland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Costello, Fiona" sort="Costello, Fiona" uniqKey="Costello F" first="Fiona" last="Costello">Fiona Costello</name>
<affiliation><nlm:affiliation>University of Calgary, Calgary, AB, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Aktas, Orhan" sort="Aktas, Orhan" uniqKey="Aktas O" first="Orhan" last="Aktas">Orhan Aktas</name>
<affiliation><nlm:affiliation>University of Düsseldorf, Düsseldorf, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Vermersch, Patrick" sort="Vermersch, Patrick" uniqKey="Vermersch P" first="Patrick" last="Vermersch">Patrick Vermersch</name>
<affiliation><nlm:affiliation>University of Lille, Lille, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Oreja Guevara, Celia" sort="Oreja Guevara, Celia" uniqKey="Oreja Guevara C" first="Celia" last="Oreja-Guevara">Celia Oreja-Guevara</name>
<affiliation><nlm:affiliation>Hospital Clinico San Carlos, Madrid, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Comi, Giancarlo" sort="Comi, Giancarlo" uniqKey="Comi G" first="Giancarlo" last="Comi">Giancarlo Comi</name>
<affiliation><nlm:affiliation>San Raffaele Hospital, Milan, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Leocani, Letizia" sort="Leocani, Letizia" uniqKey="Leocani L" first="Letizia" last="Leocani">Letizia Leocani</name>
<affiliation><nlm:affiliation>San Raffaele Hospital, Milan, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Garcia Martin, Elena" sort="Garcia Martin, Elena" uniqKey="Garcia Martin E" first="Elena" last="Garcia-Martin">Elena Garcia-Martin</name>
<affiliation><nlm:affiliation>Hospital Miguel Servet, Zaragoza, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Paul, Friedemann" sort="Paul, Friedemann" uniqKey="Paul F" first="Friedemann" last="Paul">Friedemann Paul</name>
<affiliation><nlm:affiliation>Experimental and Clinical Research Center and NeuroCure Clinical Research Center, Charité University Medicine and Max Delbrueck Center for Molecular Medicine, Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Havrdova, Eva" sort="Havrdova, Eva" uniqKey="Havrdova E" first="Eva" last="Havrdova">Eva Havrdova</name>
<affiliation><nlm:affiliation>Charles University, Prague, Czech Republic.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Frohman, Elliot" sort="Frohman, Elliot" uniqKey="Frohman E" first="Elliot" last="Frohman">Elliot Frohman</name>
<affiliation><nlm:affiliation>University of Texas Southwestern Medical Center, Dallas, TX, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Balcer, Laura J" sort="Balcer, Laura J" uniqKey="Balcer L" first="Laura J" last="Balcer">Laura J. Balcer</name>
<affiliation><nlm:affiliation>University of Pennsylvania, Philadelphia, PA, USA; New York University, New York, NY, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Green, Ari J" sort="Green, Ari J" uniqKey="Green A" first="Ari J" last="Green">Ari J. Green</name>
<affiliation><nlm:affiliation>University of California, San Francisco, CA, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Calabresi, Peter A" sort="Calabresi, Peter A" uniqKey="Calabresi P" first="Peter A" last="Calabresi">Peter A. Calabresi</name>
<affiliation><nlm:affiliation>Johns Hopkins University, Baltimore, MD, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Villoslada, Pablo" sort="Villoslada, Pablo" uniqKey="Villoslada P" first="Pablo" last="Villoslada">Pablo Villoslada</name>
<affiliation><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain; University of California, San Francisco, CA, USA. Electronic address: pvilloslada@clinic.ub.es.</nlm:affiliation>
</affiliation>
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<series><title level="j">The Lancet. Neurology</title>
<idno type="eISSN">1474-4465</idno>
<imprint><date when="2016" type="published">2016</date>
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<term>Cohort Studies</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Macula Lutea (diagnostic imaging)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multiple Sclerosis (complications)</term>
<term>Multiple Sclerosis (physiopathology)</term>
<term>Prognosis</term>
<term>Retinal Diseases (diagnostic imaging)</term>
<term>Retinal Diseases (etiology)</term>
<term>Retinal Neurons (pathology)</term>
<term>Severity of Illness Index</term>
<term>Tomography, Optical Coherence (methods)</term>
</keywords>
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<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Macula Lutea</term>
<term>Retinal Diseases</term>
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</keywords>
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<term>Disease Progression</term>
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<term>Follow-Up Studies</term>
<term>Humans</term>
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<front><div type="abstract" xml:lang="en">Most patients with multiple sclerosis without previous optic neuritis have thinner retinal layers than healthy controls. We assessed the role of peripapillary retinal nerve fibre layer (pRNFL) thickness and macular volume in eyes with no history of optic neuritis as a biomarker of disability worsening in a cohort of patients with multiple sclerosis who had at least one eye without optic neuritis available.</div>
</front>
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<DateCreated><Year>2016</Year>
<Month>06</Month>
<Day>15</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>05</Month>
<Day>29</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>05</Month>
<Day>29</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1474-4465</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>15</Volume>
<Issue>6</Issue>
<PubDate><Year>2016</Year>
<Month>May</Month>
</PubDate>
</JournalIssue>
<Title>The Lancet. Neurology</Title>
<ISOAbbreviation>Lancet Neurol</ISOAbbreviation>
</Journal>
<ArticleTitle>Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study.</ArticleTitle>
<Pagination><MedlinePgn>574-84</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/S1474-4422(16)00068-5</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">S1474-4422(16)00068-5</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Most patients with multiple sclerosis without previous optic neuritis have thinner retinal layers than healthy controls. We assessed the role of peripapillary retinal nerve fibre layer (pRNFL) thickness and macular volume in eyes with no history of optic neuritis as a biomarker of disability worsening in a cohort of patients with multiple sclerosis who had at least one eye without optic neuritis available.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">In this multicentre, cohort study, we collected data about patients (age ≥16 years old) with clinically isolated syndrome, relapsing-remitting multiple sclerosis, and progressive multiple sclerosis. Patients were recruited from centres in Spain, Italy, France, Germany, Czech Republic, Netherlands, Canada, and the USA, with the first cohort starting in 2008 and the latest cohort starting in 2013. We assessed disability worsening using the Expanded Disability Status Scale (EDSS). The pRNFL thickness and macular volume were assessed once at study entry (baseline) by optical coherence tomography (OCT) and was calculated as the mean value of both eyes without optic neuritis for patients without a history of optic neuritis or the value of the non-optic neuritis eye for patients with previous unilateral optic neuritis. Researchers who did the OCT at baseline were masked to EDSS results and the researchers assessing disability with EDSS were masked to OCT results. We estimated the association of pRNFL thickness or macular volume at baseline in eyes without optic neuritis with the risk of subsequent disability worsening by use of proportional hazards models that included OCT metrics and age, disease duration, disability, presence of previous unilateral optic neuritis, and use of disease-modifying therapies as covariates.</AbstractText>
<AbstractText Label="FINDINGS" NlmCategory="RESULTS">879 patients with clinically isolated syndrome (n=74), relapsing-remitting multiple sclerosis (n=664), or progressive multiple sclerosis (n=141) were included in the primary analyses. Disability worsening occurred in 252 (29%) of 879 patients with multiple sclerosis after a median follow-up of 2·0 years (range 0·5-5 years). Patients with a pRNFL of less than or equal to 87 μm or less than or equal to 88 μm (measured with Spectralis or Cirrus OCT devices) had double the risk of disability worsening at any time after the first and up to the third years of follow-up (hazard ratio 2·06, 95% CI 1·36-3·11; p=0·001), and the risk was increased by nearly four times after the third and up to the fifth years of follow-up (3·81, 1·63-8·91; p=0·002). We did not identify meaningful associations for macular volume.</AbstractText>
<AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">Our results provide evidence of the usefulness of monitoring pRNFL thickness by OCT for prediction of the risk of disability worsening with time in patients with multiple sclerosis.</AbstractText>
<AbstractText Label="FUNDING" NlmCategory="BACKGROUND">Instituto de Salud Carlos III.</AbstractText>
<CopyrightInformation>Copyright © 2016 Elsevier Ltd. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Martinez-Lapiscina</LastName>
<ForeName>Elena H</ForeName>
<Initials>EH</Initials>
<AffiliationInfo><Affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Arnow</LastName>
<ForeName>Sam</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>University of California, San Francisco, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wilson</LastName>
<ForeName>James A</ForeName>
<Initials>JA</Initials>
<AffiliationInfo><Affiliation>University of Pennsylvania, Philadelphia, PA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Saidha</LastName>
<ForeName>Shiv</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Johns Hopkins University, Baltimore, MD, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Preiningerova</LastName>
<ForeName>Jana Lizrova</ForeName>
<Initials>JL</Initials>
<AffiliationInfo><Affiliation>Charles University, Prague, Czech Republic.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Oberwahrenbrock</LastName>
<ForeName>Timm</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Experimental and Clinical Research Center and NeuroCure Clinical Research Center, Charité University Medicine and Max Delbrueck Center for Molecular Medicine, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Brandt</LastName>
<ForeName>Alexander U</ForeName>
<Initials>AU</Initials>
<AffiliationInfo><Affiliation>Experimental and Clinical Research Center and NeuroCure Clinical Research Center, Charité University Medicine and Max Delbrueck Center for Molecular Medicine, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pablo</LastName>
<ForeName>Luis E</ForeName>
<Initials>LE</Initials>
<AffiliationInfo><Affiliation>Hospital Miguel Servet, Zaragoza, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Guerrieri</LastName>
<ForeName>Simone</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>San Raffaele Hospital, Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gonzalez</LastName>
<ForeName>Ines</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Hospital Clinico San Carlos, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Outteryck</LastName>
<ForeName>Olivier</ForeName>
<Initials>O</Initials>
<AffiliationInfo><Affiliation>University of Lille, Lille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mueller</LastName>
<ForeName>Ann-Kristin</ForeName>
<Initials>AK</Initials>
<AffiliationInfo><Affiliation>University of Düsseldorf, Düsseldorf, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Albrecht</LastName>
<ForeName>Phillip</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>University of Düsseldorf, Düsseldorf, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chan</LastName>
<ForeName>Wesley</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>University of Calgary, Calgary, AB, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lukas</LastName>
<ForeName>Sebastian</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>University of Zurich, Zurich, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Balk</LastName>
<ForeName>Lisanne J</ForeName>
<Initials>LJ</Initials>
<AffiliationInfo><Affiliation>VU Medical Center, Amsterdam, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fraser</LastName>
<ForeName>Clare</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Save Sight Institute, University of Sydney, NSW, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Frederiksen</LastName>
<ForeName>Jette L</ForeName>
<Initials>JL</Initials>
<AffiliationInfo><Affiliation>Glostrup Hospital, University of Copenhagen, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Resto</LastName>
<ForeName>Jennifer</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Cleveland Clinic Foundation, Cleveland, OH, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Frohman</LastName>
<ForeName>Teresa</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>University of Texas Southwestern Medical Center, Dallas, TX, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cordano</LastName>
<ForeName>Christian</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>University of California, San Francisco, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zubizarreta</LastName>
<ForeName>Irati</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Andorra</LastName>
<ForeName>Magi</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sanchez-Dalmau</LastName>
<ForeName>Bernardo</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Saiz</LastName>
<ForeName>Albert</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bermel</LastName>
<ForeName>Robert</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Cleveland Clinic Foundation, Cleveland, OH, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Klistorner</LastName>
<ForeName>Alexander</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Save Sight Institute, University of Sydney, NSW, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Petzold</LastName>
<ForeName>Axel</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>VU Medical Center, Amsterdam, Netherlands; Moorfields Eye Hospital, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schippling</LastName>
<ForeName>Sven</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>University of Zurich, Zurich, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Costello</LastName>
<ForeName>Fiona</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>University of Calgary, Calgary, AB, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Aktas</LastName>
<ForeName>Orhan</ForeName>
<Initials>O</Initials>
<AffiliationInfo><Affiliation>University of Düsseldorf, Düsseldorf, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vermersch</LastName>
<ForeName>Patrick</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>University of Lille, Lille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Oreja-Guevara</LastName>
<ForeName>Celia</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Hospital Clinico San Carlos, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Comi</LastName>
<ForeName>Giancarlo</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>San Raffaele Hospital, Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Leocani</LastName>
<ForeName>Letizia</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>San Raffaele Hospital, Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Garcia-Martin</LastName>
<ForeName>Elena</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Hospital Miguel Servet, Zaragoza, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Paul</LastName>
<ForeName>Friedemann</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Experimental and Clinical Research Center and NeuroCure Clinical Research Center, Charité University Medicine and Max Delbrueck Center for Molecular Medicine, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Havrdova</LastName>
<ForeName>Eva</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Charles University, Prague, Czech Republic.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Frohman</LastName>
<ForeName>Elliot</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>University of Texas Southwestern Medical Center, Dallas, TX, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Balcer</LastName>
<ForeName>Laura J</ForeName>
<Initials>LJ</Initials>
<AffiliationInfo><Affiliation>University of Pennsylvania, Philadelphia, PA, USA; New York University, New York, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Green</LastName>
<ForeName>Ari J</ForeName>
<Initials>AJ</Initials>
<AffiliationInfo><Affiliation>University of California, San Francisco, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Calabresi</LastName>
<ForeName>Peter A</ForeName>
<Initials>PA</Initials>
<AffiliationInfo><Affiliation>Johns Hopkins University, Baltimore, MD, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Villoslada</LastName>
<ForeName>Pablo</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain; University of California, San Francisco, CA, USA. Electronic address: pvilloslada@clinic.ub.es.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><CollectiveName>IMSVISUAL consortium</CollectiveName>
</Author>
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<Language>eng</Language>
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<PublicationType UI="D016448">Multicenter Study</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>03</Month>
<Day>18</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
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<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
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<MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName>
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<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009103" MajorTopicYN="N">Multiple Sclerosis</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName>
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<MeshHeading><DescriptorName UI="D012164" MajorTopicYN="N">Retinal Diseases</DescriptorName>
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<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
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<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
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<QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
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<Month>11</Month>
<Day>10</Day>
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<PubMedPubDate PubStatus="revised"><Year>2016</Year>
<Month>02</Month>
<Day>10</Day>
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<PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>02</Month>
<Day>11</Day>
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