Human papillomavirus and post-transplant cutaneous squamous-cell carcinoma: a multicenter, prospective cohort study.
Identifieur interne : 000A62 ( PubMed/Checkpoint ); précédent : 000A61; suivant : 000A63Human papillomavirus and post-transplant cutaneous squamous-cell carcinoma: a multicenter, prospective cohort study.
Auteurs : Jan Nico Bouwes Bavinck [Pays-Bas] ; Mariet C W. Feltkamp [Pays-Bas] ; Adele C. Green [Australie] ; Marta Fiocco [Pays-Bas] ; Sylvie Euvrard [France] ; Catherine A. Harwood [Royaume-Uni] ; Charlotte M. Proby [Royaume-Uni] ; Luigi Naldi [Italie] ; Janouk C D. Diphoorn [Italie] ; Anna Venturuzzo [Italie] ; Gianpaolo Tessari [Italie] ; Ingo Nindl [Allemagne] ; Francesca Sampogna [Italie] ; Damiano Abeni [Italie] ; Rachel E. Neale [Australie] ; Jelle J. Goeman [Pays-Bas] ; Koen D. Quint [Pays-Bas] ; Anne Berthe Halk [Pays-Bas] ; Carmen Sneek [Pays-Bas] ; Roel E. Genders [Pays-Bas] ; Maurits N C. De Koning [Pays-Bas] ; Wim G V. Quint [Pays-Bas] ; Ulrike Wieland [Allemagne] ; Sönke Weissenborn [Allemagne] ; Tim Waterboer [Allemagne] ; Michael Pawlita [Allemagne] ; Herbert Pfister [Allemagne]Source :
- American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [ 1600-6143 ] ; 2017.
Abstract
Organ-transplant recipients (OTR) have a 100-fold increased risk of cutaneous squamous-cell carcinoma (cSCC). We prospectively evaluated the association between beta-genus human-papillomaviruses (betaPV) and keratinocyte carcinoma in OTR. Two OTR cohorts without cSCC were assembled: cohort 1 transplanted in 2003-2006 (n=274) and cohort 2 in 1986-2002 (n=352). Participants were followed until death or cessation of follow-up in 2016. BetaPV infection was assessed in eyebrow hairs using PCR-based methods. BetaPV IgG seroresponses were determined by multiplex serology. A competing risk model with delayed entry was used to estimate cumulative incidence of histologically proven cSCC and the effect of betaPV using a multivariable Cox regression model. Results are reported as adjusted hazard ratios (HR). OTR with ≥5 different betaPV types in eyebrow hairs had 1.7 times the risk of cSCC versus those with 0-4 different types (HR: 1.7 (1.1;2.6)). A similar risk was seen with high betaPV loads (HR: 1.8 (1.2;2.8)). No significant associations were seen between serum antibodies and cSCC or between betaPV and basal-cell carcinoma. The diversity and load of betaPV types in eyebrow hairs are associated with cSCC risk in OTR, providing evidence that betaPV is associated with cSCC carcinogenesis and may present a target for future preventive strategies. This article is protected by copyright. All rights reserved.
DOI: 10.1111/ajt.14537
PubMed: 29024374
Affiliations:
- Allemagne, Australie, France, Italie, Pays-Bas, Royaume-Uni
- Angleterre, Auvergne-Rhône-Alpes, Bade-Wurtemberg, Berlin, District de Karlsruhe, Grand Londres, Hollande-Méridionale, Latium, Rhône-Alpes
- Berlin, Heidelberg, Leyde, Londres, Lyon, Rome
- Université de Londres
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Harwood</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Cutaneous Research, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cutaneous Research, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Proby, Charlotte M" sort="Proby, Charlotte M" uniqKey="Proby C" first="Charlotte M" last="Proby">Charlotte M. Proby</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Research, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Cancer Research, University of Dundee, Ninewells Hospital and Medical School, Dundee</wicri:regionArea><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="Naldi, Luigi" sort="Naldi, Luigi" uniqKey="Naldi L" first="Luigi" last="Naldi">Luigi Naldi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, Azienda Ospedaliera papa Giovanni XXIII, GISED Study Center Bergamo, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Dermatology, Azienda Ospedaliera papa Giovanni XXIII, GISED Study Center Bergamo</wicri:regionArea><wicri:noRegion>GISED Study Center Bergamo</wicri:noRegion></affiliation></author><author><name sortKey="Diphoorn, Janouk C D" sort="Diphoorn, Janouk C D" uniqKey="Diphoorn J" first="Janouk C D" last="Diphoorn">Janouk C D. Diphoorn</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, Azienda Ospedaliera papa Giovanni XXIII, GISED Study Center Bergamo, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Dermatology, Azienda Ospedaliera papa Giovanni XXIII, GISED Study Center Bergamo</wicri:regionArea><wicri:noRegion>GISED Study Center Bergamo</wicri:noRegion></affiliation></author><author><name sortKey="Venturuzzo, Anna" sort="Venturuzzo, Anna" uniqKey="Venturuzzo A" first="Anna" last="Venturuzzo">Anna Venturuzzo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, Azienda Ospedaliera papa Giovanni XXIII, GISED Study Center Bergamo, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Dermatology, Azienda Ospedaliera papa Giovanni XXIII, GISED Study Center Bergamo</wicri:regionArea><wicri:noRegion>GISED Study Center Bergamo</wicri:noRegion></affiliation></author><author><name sortKey="Tessari, Gianpaolo" sort="Tessari, Gianpaolo" uniqKey="Tessari G" first="Gianpaolo" last="Tessari">Gianpaolo Tessari</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical and Surgical Sciences, Section of Dermatology, University of Verona, c/o Ospedale Civile Maggiore, Verona, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biomedical and Surgical Sciences, Section of Dermatology, University of Verona, c/o Ospedale Civile Maggiore, Verona</wicri:regionArea><wicri:noRegion>Verona</wicri:noRegion></affiliation></author><author><name sortKey="Nindl, Ingo" sort="Nindl, Ingo" uniqKey="Nindl I" first="Ingo" last="Nindl">Ingo Nindl</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, University Hospital Charité, Skin Cancer Center Charité, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology, University Hospital Charité, Skin Cancer Center Charité, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Sampogna, Francesca" sort="Sampogna, Francesca" uniqKey="Sampogna F" first="Francesca" last="Sampogna">Francesca Sampogna</name><affiliation wicri:level="3"><nlm:affiliation>Clinical Epidemiology Unit, IDI-IRCCS FLMM, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Clinical Epidemiology Unit, IDI-IRCCS FLMM, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Abeni, Damiano" sort="Abeni, Damiano" uniqKey="Abeni D" first="Damiano" last="Abeni">Damiano Abeni</name><affiliation wicri:level="3"><nlm:affiliation>Clinical Epidemiology Unit, IDI-IRCCS FLMM, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Clinical Epidemiology Unit, IDI-IRCCS FLMM, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Neale, Rachel E" sort="Neale, Rachel E" uniqKey="Neale R" first="Rachel E" last="Neale">Rachel E. Neale</name><affiliation wicri:level="1"><nlm:affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>QIMR Berghofer Medical Research Institute, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Goeman, Jelle J" sort="Goeman, Jelle J" uniqKey="Goeman J" first="Jelle J" last="Goeman">Jelle J. Goeman</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Statistics, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Statistics, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Quint, Koen D" sort="Quint, Koen D" uniqKey="Quint K" first="Koen D" last="Quint">Koen D. Quint</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Dermatology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Halk, Anne Berthe" sort="Halk, Anne Berthe" uniqKey="Halk A" first="Anne Berthe" last="Halk">Anne Berthe Halk</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Dermatology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Sneek, Carmen" sort="Sneek, Carmen" uniqKey="Sneek C" first="Carmen" last="Sneek">Carmen Sneek</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Dermatology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Genders, Roel E" sort="Genders, Roel E" uniqKey="Genders R" first="Roel E" last="Genders">Roel E. Genders</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Dermatology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="De Koning, Maurits N C" sort="De Koning, Maurits N C" uniqKey="De Koning M" first="Maurits N C" last="De Koning">Maurits N C. De Koning</name><affiliation wicri:level="1"><nlm:affiliation>DDL Diagnostic Laboratory, Rijswijk, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>DDL Diagnostic Laboratory, Rijswijk</wicri:regionArea><wicri:noRegion>Rijswijk</wicri:noRegion></affiliation></author><author><name sortKey="Quint, Wim G V" sort="Quint, Wim G V" uniqKey="Quint W" first="Wim G V" last="Quint">Wim G V. Quint</name><affiliation wicri:level="1"><nlm:affiliation>DDL Diagnostic Laboratory, Rijswijk, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>DDL Diagnostic Laboratory, Rijswijk</wicri:regionArea><wicri:noRegion>Rijswijk</wicri:noRegion></affiliation></author><author><name sortKey="Wieland, Ulrike" sort="Wieland, Ulrike" uniqKey="Wieland U" first="Ulrike" last="Wieland">Ulrike Wieland</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Virology, University of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Virology, University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Weissenborn, Sonke" sort="Weissenborn, Sonke" uniqKey="Weissenborn S" first="Sönke" last="Weissenborn">Sönke Weissenborn</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Virology, University of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Virology, University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Waterboer, Tim" sort="Waterboer, Tim" uniqKey="Waterboer T" first="Tim" last="Waterboer">Tim Waterboer</name><affiliation wicri:level="3"><nlm:affiliation>German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Pawlita, Michael" sort="Pawlita, Michael" uniqKey="Pawlita M" first="Michael" last="Pawlita">Michael Pawlita</name><affiliation wicri:level="3"><nlm:affiliation>German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Pfister, Herbert" sort="Pfister, Herbert" uniqKey="Pfister H" first="Herbert" last="Pfister">Herbert Pfister</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Virology, University of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Virology, University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:29024374</idno><idno type="pmid">29024374</idno><idno type="doi">10.1111/ajt.14537</idno><idno type="wicri:Area/PubMed/Corpus">000267</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000267</idno><idno type="wicri:Area/PubMed/Curation">000265</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000265</idno><idno type="wicri:Area/PubMed/Checkpoint">000265</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000265</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Human papillomavirus and post-transplant cutaneous squamous-cell carcinoma: a multicenter, prospective cohort study.</title><author><name sortKey="Bouwes Bavinck, Jan Nico" sort="Bouwes Bavinck, Jan Nico" uniqKey="Bouwes Bavinck J" first="Jan Nico" last="Bouwes Bavinck">Jan Nico Bouwes Bavinck</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Dermatology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Feltkamp, Mariet C W" sort="Feltkamp, Mariet C W" uniqKey="Feltkamp M" first="Mariet C W" last="Feltkamp">Mariet C W. Feltkamp</name><affiliation wicri:level="3"><nlm:affiliation>Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Medical Microbiology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Green, Adele C" sort="Green, Adele C" uniqKey="Green A" first="Adele C" last="Green">Adele C. Green</name><affiliation wicri:level="1"><nlm:affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>QIMR Berghofer Medical Research Institute, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Fiocco, Marta" sort="Fiocco, Marta" uniqKey="Fiocco M" first="Marta" last="Fiocco">Marta Fiocco</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Statistics, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Statistics, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Euvrard, Sylvie" sort="Euvrard, Sylvie" uniqKey="Euvrard S" first="Sylvie" last="Euvrard">Sylvie Euvrard</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Dermatology, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Harwood, Catherine A" sort="Harwood, Catherine A" uniqKey="Harwood C" first="Catherine A" last="Harwood">Catherine A. Harwood</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Cutaneous Research, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cutaneous Research, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Proby, Charlotte M" sort="Proby, Charlotte M" uniqKey="Proby C" first="Charlotte M" last="Proby">Charlotte M. Proby</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Research, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Cancer Research, University of Dundee, Ninewells Hospital and Medical School, Dundee</wicri:regionArea><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="Naldi, Luigi" sort="Naldi, Luigi" uniqKey="Naldi L" first="Luigi" last="Naldi">Luigi Naldi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, Azienda Ospedaliera papa Giovanni XXIII, GISED Study Center Bergamo, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Dermatology, Azienda Ospedaliera papa Giovanni XXIII, GISED Study Center Bergamo</wicri:regionArea><wicri:noRegion>GISED Study Center Bergamo</wicri:noRegion></affiliation></author><author><name sortKey="Diphoorn, Janouk C D" sort="Diphoorn, Janouk C D" uniqKey="Diphoorn J" first="Janouk C D" last="Diphoorn">Janouk C D. Diphoorn</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, Azienda Ospedaliera papa Giovanni XXIII, GISED Study Center Bergamo, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Dermatology, Azienda Ospedaliera papa Giovanni XXIII, GISED Study Center Bergamo</wicri:regionArea><wicri:noRegion>GISED Study Center Bergamo</wicri:noRegion></affiliation></author><author><name sortKey="Venturuzzo, Anna" sort="Venturuzzo, Anna" uniqKey="Venturuzzo A" first="Anna" last="Venturuzzo">Anna Venturuzzo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, Azienda Ospedaliera papa Giovanni XXIII, GISED Study Center Bergamo, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Dermatology, Azienda Ospedaliera papa Giovanni XXIII, GISED Study Center Bergamo</wicri:regionArea><wicri:noRegion>GISED Study Center Bergamo</wicri:noRegion></affiliation></author><author><name sortKey="Tessari, Gianpaolo" sort="Tessari, Gianpaolo" uniqKey="Tessari G" first="Gianpaolo" last="Tessari">Gianpaolo Tessari</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical and Surgical Sciences, Section of Dermatology, University of Verona, c/o Ospedale Civile Maggiore, Verona, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biomedical and Surgical Sciences, Section of Dermatology, University of Verona, c/o Ospedale Civile Maggiore, Verona</wicri:regionArea><wicri:noRegion>Verona</wicri:noRegion></affiliation></author><author><name sortKey="Nindl, Ingo" sort="Nindl, Ingo" uniqKey="Nindl I" first="Ingo" last="Nindl">Ingo Nindl</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, University Hospital Charité, Skin Cancer Center Charité, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology, University Hospital Charité, Skin Cancer Center Charité, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Sampogna, Francesca" sort="Sampogna, Francesca" uniqKey="Sampogna F" first="Francesca" last="Sampogna">Francesca Sampogna</name><affiliation wicri:level="3"><nlm:affiliation>Clinical Epidemiology Unit, IDI-IRCCS FLMM, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Clinical Epidemiology Unit, IDI-IRCCS FLMM, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Abeni, Damiano" sort="Abeni, Damiano" uniqKey="Abeni D" first="Damiano" last="Abeni">Damiano Abeni</name><affiliation wicri:level="3"><nlm:affiliation>Clinical Epidemiology Unit, IDI-IRCCS FLMM, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Clinical Epidemiology Unit, IDI-IRCCS FLMM, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Neale, Rachel E" sort="Neale, Rachel E" uniqKey="Neale R" first="Rachel E" last="Neale">Rachel E. Neale</name><affiliation wicri:level="1"><nlm:affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>QIMR Berghofer Medical Research Institute, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Goeman, Jelle J" sort="Goeman, Jelle J" uniqKey="Goeman J" first="Jelle J" last="Goeman">Jelle J. Goeman</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Statistics, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Statistics, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Quint, Koen D" sort="Quint, Koen D" uniqKey="Quint K" first="Koen D" last="Quint">Koen D. Quint</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Dermatology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Halk, Anne Berthe" sort="Halk, Anne Berthe" uniqKey="Halk A" first="Anne Berthe" last="Halk">Anne Berthe Halk</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Dermatology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Sneek, Carmen" sort="Sneek, Carmen" uniqKey="Sneek C" first="Carmen" last="Sneek">Carmen Sneek</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Dermatology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Genders, Roel E" sort="Genders, Roel E" uniqKey="Genders R" first="Roel E" last="Genders">Roel E. Genders</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Dermatology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="De Koning, Maurits N C" sort="De Koning, Maurits N C" uniqKey="De Koning M" first="Maurits N C" last="De Koning">Maurits N C. De Koning</name><affiliation wicri:level="1"><nlm:affiliation>DDL Diagnostic Laboratory, Rijswijk, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>DDL Diagnostic Laboratory, Rijswijk</wicri:regionArea><wicri:noRegion>Rijswijk</wicri:noRegion></affiliation></author><author><name sortKey="Quint, Wim G V" sort="Quint, Wim G V" uniqKey="Quint W" first="Wim G V" last="Quint">Wim G V. Quint</name><affiliation wicri:level="1"><nlm:affiliation>DDL Diagnostic Laboratory, Rijswijk, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>DDL Diagnostic Laboratory, Rijswijk</wicri:regionArea><wicri:noRegion>Rijswijk</wicri:noRegion></affiliation></author><author><name sortKey="Wieland, Ulrike" sort="Wieland, Ulrike" uniqKey="Wieland U" first="Ulrike" last="Wieland">Ulrike Wieland</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Virology, University of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Virology, University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Weissenborn, Sonke" sort="Weissenborn, Sonke" uniqKey="Weissenborn S" first="Sönke" last="Weissenborn">Sönke Weissenborn</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Virology, University of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Virology, University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Waterboer, Tim" sort="Waterboer, Tim" uniqKey="Waterboer T" first="Tim" last="Waterboer">Tim Waterboer</name><affiliation wicri:level="3"><nlm:affiliation>German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Pawlita, Michael" sort="Pawlita, Michael" uniqKey="Pawlita M" first="Michael" last="Pawlita">Michael Pawlita</name><affiliation wicri:level="3"><nlm:affiliation>German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Pfister, Herbert" sort="Pfister, Herbert" uniqKey="Pfister H" first="Herbert" last="Pfister">Herbert Pfister</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Virology, University of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Virology, University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author></analytic><series><title level="j">American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</title><idno type="eISSN">1600-6143</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Organ-transplant recipients (OTR) have a 100-fold increased risk of cutaneous squamous-cell carcinoma (cSCC). We prospectively evaluated the association between beta-genus human-papillomaviruses (betaPV) and keratinocyte carcinoma in OTR. Two OTR cohorts without cSCC were assembled: cohort 1 transplanted in 2003-2006 (n=274) and cohort 2 in 1986-2002 (n=352). Participants were followed until death or cessation of follow-up in 2016. BetaPV infection was assessed in eyebrow hairs using PCR-based methods. BetaPV IgG seroresponses were determined by multiplex serology. A competing risk model with delayed entry was used to estimate cumulative incidence of histologically proven cSCC and the effect of betaPV using a multivariable Cox regression model. Results are reported as adjusted hazard ratios (HR). OTR with ≥5 different betaPV types in eyebrow hairs had 1.7 times the risk of cSCC versus those with 0-4 different types (HR: 1.7 (1.1;2.6)). A similar risk was seen with high betaPV loads (HR: 1.8 (1.2;2.8)). No significant associations were seen between serum antibodies and cSCC or between betaPV and basal-cell carcinoma. The diversity and load of betaPV types in eyebrow hairs are associated with cSCC risk in OTR, providing evidence that betaPV is associated with cSCC carcinogenesis and may present a target for future preventive strategies. This article is protected by copyright. All rights reserved.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">29024374</PMID><DateCreated><Year>2017</Year><Month>10</Month><Day>12</Day></DateCreated><DateRevised><Year>2017</Year><Month>10</Month><Day>12</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1600-6143</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2017</Year><Month>Oct</Month><Day>11</Day></PubDate></JournalIssue><Title>American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</Title><ISOAbbreviation>Am. J. Transplant.</ISOAbbreviation></Journal><ArticleTitle>Human papillomavirus and post-transplant cutaneous squamous-cell carcinoma: a multicenter, prospective cohort study.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1111/ajt.14537</ELocationID><Abstract><AbstractText>Organ-transplant recipients (OTR) have a 100-fold increased risk of cutaneous squamous-cell carcinoma (cSCC). We prospectively evaluated the association between beta-genus human-papillomaviruses (betaPV) and keratinocyte carcinoma in OTR. Two OTR cohorts without cSCC were assembled: cohort 1 transplanted in 2003-2006 (n=274) and cohort 2 in 1986-2002 (n=352). Participants were followed until death or cessation of follow-up in 2016. BetaPV infection was assessed in eyebrow hairs using PCR-based methods. BetaPV IgG seroresponses were determined by multiplex serology. A competing risk model with delayed entry was used to estimate cumulative incidence of histologically proven cSCC and the effect of betaPV using a multivariable Cox regression model. Results are reported as adjusted hazard ratios (HR). OTR with ≥5 different betaPV types in eyebrow hairs had 1.7 times the risk of cSCC versus those with 0-4 different types (HR: 1.7 (1.1;2.6)). A similar risk was seen with high betaPV loads (HR: 1.8 (1.2;2.8)). No significant associations were seen between serum antibodies and cSCC or between betaPV and basal-cell carcinoma. The diversity and load of betaPV types in eyebrow hairs are associated with cSCC risk in OTR, providing evidence that betaPV is associated with cSCC carcinogenesis and may present a target for future preventive strategies. This article is protected by copyright. All rights reserved.</AbstractText><CopyrightInformation>This article is protected by copyright. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bouwes Bavinck</LastName><ForeName>Jan Nico</ForeName><Initials>JN</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Feltkamp</LastName><ForeName>Mariet C W</ForeName><Initials>MCW</Initials><AffiliationInfo><Affiliation>Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Green</LastName><ForeName>Adele C</ForeName><Initials>AC</Initials><AffiliationInfo><Affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fiocco</LastName><ForeName>Marta</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medical Statistics, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Mathematics, Leiden University, Leiden, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Euvrard</LastName><ForeName>Sylvie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Harwood</LastName><ForeName>Catherine A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Centre for Cutaneous Research, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Proby</LastName><ForeName>Charlotte M</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>Division of Cancer Research, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Naldi</LastName><ForeName>Luigi</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Azienda Ospedaliera papa Giovanni XXIII, GISED Study Center Bergamo, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Diphoorn</LastName><ForeName>Janouk C D</ForeName><Initials>JCD</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Azienda Ospedaliera papa Giovanni XXIII, GISED Study Center Bergamo, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Venturuzzo</LastName><ForeName>Anna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Azienda Ospedaliera papa Giovanni XXIII, GISED Study Center Bergamo, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tessari</LastName><ForeName>Gianpaolo</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Biomedical and Surgical Sciences, Section of Dermatology, University of Verona, c/o Ospedale Civile Maggiore, Verona, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nindl</LastName><ForeName>Ingo</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Dermatology, University Hospital Charité, Skin Cancer Center Charité, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sampogna</LastName><ForeName>Francesca</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Clinical Epidemiology Unit, IDI-IRCCS FLMM, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abeni</LastName><ForeName>Damiano</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Clinical Epidemiology Unit, IDI-IRCCS FLMM, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Neale</LastName><ForeName>Rachel E</ForeName><Initials>RE</Initials><AffiliationInfo><Affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goeman</LastName><ForeName>Jelle J</ForeName><Initials>JJ</Initials><AffiliationInfo><Affiliation>Department of Medical Statistics, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Quint</LastName><ForeName>Koen D</ForeName><Initials>KD</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Halk</LastName><ForeName>Anne Berthe</ForeName><Initials>AB</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sneek</LastName><ForeName>Carmen</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Genders</LastName><ForeName>Roel E</ForeName><Initials>RE</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Koning</LastName><ForeName>Maurits N C</ForeName><Initials>MNC</Initials><AffiliationInfo><Affiliation>DDL Diagnostic Laboratory, Rijswijk, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Quint</LastName><ForeName>Wim G V</ForeName><Initials>WGV</Initials><AffiliationInfo><Affiliation>DDL Diagnostic Laboratory, Rijswijk, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wieland</LastName><ForeName>Ulrike</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Institute of Virology, University of Cologne, Cologne, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weissenborn</LastName><ForeName>Sönke</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute of Virology, University of Cologne, Cologne, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Waterboer</LastName><ForeName>Tim</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pawlita</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pfister</LastName><ForeName>Herbert</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Institute of Virology, University of Cologne, Cologne, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>EPI-HPV-UV-CA group</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>10</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Transplant</MedlineTA><NlmUniqueID>100968638</NlmUniqueID><ISSNLinking>1600-6135</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>10</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>10</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>10</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29024374</ArticleId><ArticleId IdType="doi">10.1111/ajt.14537</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Auvergne-Rhône-Alpes</li><li>Bade-Wurtemberg</li><li>Berlin</li><li>District de Karlsruhe</li><li>Grand Londres</li><li>Hollande-Méridionale</li><li>Latium</li><li>Rhône-Alpes</li></region><settlement><li>Berlin</li><li>Heidelberg</li><li>Leyde</li><li>Londres</li><li>Lyon</li><li>Rome</li></settlement><orgName><li>Université de Londres</li></orgName></list><tree><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Bouwes Bavinck, Jan Nico" sort="Bouwes Bavinck, Jan Nico" uniqKey="Bouwes Bavinck J" first="Jan Nico" last="Bouwes Bavinck">Jan Nico Bouwes Bavinck</name></region><name sortKey="De Koning, Maurits N C" sort="De Koning, Maurits N C" uniqKey="De Koning M" first="Maurits N C" last="De Koning">Maurits N C. De Koning</name><name sortKey="Feltkamp, Mariet C W" sort="Feltkamp, Mariet C W" uniqKey="Feltkamp M" first="Mariet C W" last="Feltkamp">Mariet C W. Feltkamp</name><name sortKey="Fiocco, Marta" sort="Fiocco, Marta" uniqKey="Fiocco M" first="Marta" last="Fiocco">Marta Fiocco</name><name sortKey="Genders, Roel E" sort="Genders, Roel E" uniqKey="Genders R" first="Roel E" last="Genders">Roel E. Genders</name><name sortKey="Goeman, Jelle J" sort="Goeman, Jelle J" uniqKey="Goeman J" first="Jelle J" last="Goeman">Jelle J. Goeman</name><name sortKey="Halk, Anne Berthe" sort="Halk, Anne Berthe" uniqKey="Halk A" first="Anne Berthe" last="Halk">Anne Berthe Halk</name><name sortKey="Quint, Koen D" sort="Quint, Koen D" uniqKey="Quint K" first="Koen D" last="Quint">Koen D. Quint</name><name sortKey="Quint, Wim G V" sort="Quint, Wim G V" uniqKey="Quint W" first="Wim G V" last="Quint">Wim G V. Quint</name><name sortKey="Sneek, Carmen" sort="Sneek, Carmen" uniqKey="Sneek C" first="Carmen" last="Sneek">Carmen Sneek</name></country><country name="Australie"><noRegion><name sortKey="Green, Adele C" sort="Green, Adele C" uniqKey="Green A" first="Adele C" last="Green">Adele C. Green</name></noRegion><name sortKey="Neale, Rachel E" sort="Neale, Rachel E" uniqKey="Neale R" first="Rachel E" last="Neale">Rachel E. Neale</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Euvrard, Sylvie" sort="Euvrard, Sylvie" uniqKey="Euvrard S" first="Sylvie" last="Euvrard">Sylvie Euvrard</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Harwood, Catherine A" sort="Harwood, Catherine A" uniqKey="Harwood C" first="Catherine A" last="Harwood">Catherine A. Harwood</name></region><name sortKey="Proby, Charlotte M" sort="Proby, Charlotte M" uniqKey="Proby C" first="Charlotte M" last="Proby">Charlotte M. Proby</name></country><country name="Italie"><noRegion><name sortKey="Naldi, Luigi" sort="Naldi, Luigi" uniqKey="Naldi L" first="Luigi" last="Naldi">Luigi Naldi</name></noRegion><name sortKey="Abeni, Damiano" sort="Abeni, Damiano" uniqKey="Abeni D" first="Damiano" last="Abeni">Damiano Abeni</name><name sortKey="Diphoorn, Janouk C D" sort="Diphoorn, Janouk C D" uniqKey="Diphoorn J" first="Janouk C D" last="Diphoorn">Janouk C D. Diphoorn</name><name sortKey="Sampogna, Francesca" sort="Sampogna, Francesca" uniqKey="Sampogna F" first="Francesca" last="Sampogna">Francesca Sampogna</name><name sortKey="Tessari, Gianpaolo" sort="Tessari, Gianpaolo" uniqKey="Tessari G" first="Gianpaolo" last="Tessari">Gianpaolo Tessari</name><name sortKey="Venturuzzo, Anna" sort="Venturuzzo, Anna" uniqKey="Venturuzzo A" first="Anna" last="Venturuzzo">Anna Venturuzzo</name></country><country name="Allemagne"><region name="Berlin"><name sortKey="Nindl, Ingo" sort="Nindl, Ingo" uniqKey="Nindl I" first="Ingo" last="Nindl">Ingo Nindl</name></region><name sortKey="Pawlita, Michael" sort="Pawlita, Michael" uniqKey="Pawlita M" first="Michael" last="Pawlita">Michael Pawlita</name><name sortKey="Pfister, Herbert" sort="Pfister, Herbert" uniqKey="Pfister H" first="Herbert" last="Pfister">Herbert Pfister</name><name sortKey="Waterboer, Tim" sort="Waterboer, Tim" uniqKey="Waterboer T" first="Tim" last="Waterboer">Tim Waterboer</name><name sortKey="Weissenborn, Sonke" sort="Weissenborn, Sonke" uniqKey="Weissenborn S" first="Sönke" last="Weissenborn">Sönke Weissenborn</name><name sortKey="Wieland, Ulrike" sort="Wieland, Ulrike" uniqKey="Wieland U" first="Ulrike" last="Wieland">Ulrike Wieland</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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