Human papillomavirus and post-transplant cutaneous squamous-cell carcinoma: a multicenter, prospective cohort study.
Identifieur interne : 000267 ( PubMed/Corpus ); précédent : 000266; suivant : 000268Human papillomavirus and post-transplant cutaneous squamous-cell carcinoma: a multicenter, prospective cohort study.
Auteurs : Jan Nico Bouwes Bavinck ; Mariet C W. Feltkamp ; Adele C. Green ; Marta Fiocco ; Sylvie Euvrard ; Catherine A. Harwood ; Charlotte M. Proby ; Luigi Naldi ; Janouk C D. Diphoorn ; Anna Venturuzzo ; Gianpaolo Tessari ; Ingo Nindl ; Francesca Sampogna ; Damiano Abeni ; Rachel E. Neale ; Jelle J. Goeman ; Koen D. Quint ; Anne Berthe Halk ; Carmen Sneek ; Roel E. Genders ; Maurits N C. De Koning ; Wim G V. Quint ; Ulrike Wieland ; Sönke Weissenborn ; Tim Waterboer ; Michael Pawlita ; Herbert PfisterSource :
- American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [ 1600-6143 ] ; 2017.
Abstract
Organ-transplant recipients (OTR) have a 100-fold increased risk of cutaneous squamous-cell carcinoma (cSCC). We prospectively evaluated the association between beta-genus human-papillomaviruses (betaPV) and keratinocyte carcinoma in OTR. Two OTR cohorts without cSCC were assembled: cohort 1 transplanted in 2003-2006 (n=274) and cohort 2 in 1986-2002 (n=352). Participants were followed until death or cessation of follow-up in 2016. BetaPV infection was assessed in eyebrow hairs using PCR-based methods. BetaPV IgG seroresponses were determined by multiplex serology. A competing risk model with delayed entry was used to estimate cumulative incidence of histologically proven cSCC and the effect of betaPV using a multivariable Cox regression model. Results are reported as adjusted hazard ratios (HR). OTR with ≥5 different betaPV types in eyebrow hairs had 1.7 times the risk of cSCC versus those with 0-4 different types (HR: 1.7 (1.1;2.6)). A similar risk was seen with high betaPV loads (HR: 1.8 (1.2;2.8)). No significant associations were seen between serum antibodies and cSCC or between betaPV and basal-cell carcinoma. The diversity and load of betaPV types in eyebrow hairs are associated with cSCC risk in OTR, providing evidence that betaPV is associated with cSCC carcinogenesis and may present a target for future preventive strategies. This article is protected by copyright. All rights reserved.
DOI: 10.1111/ajt.14537
PubMed: 29024374
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Human papillomavirus and post-transplant cutaneous squamous-cell carcinoma: a multicenter, prospective cohort study.</title><author><name sortKey="Bouwes Bavinck, Jan Nico" sort="Bouwes Bavinck, Jan Nico" uniqKey="Bouwes Bavinck J" first="Jan Nico" last="Bouwes Bavinck">Jan Nico Bouwes Bavinck</name><affiliation><nlm:affiliation>Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Feltkamp, Mariet C W" sort="Feltkamp, Mariet C W" uniqKey="Feltkamp M" first="Mariet C W" last="Feltkamp">Mariet C W. Feltkamp</name><affiliation><nlm:affiliation>Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Green, Adele C" sort="Green, Adele C" uniqKey="Green A" first="Adele C" last="Green">Adele C. Green</name><affiliation><nlm:affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Fiocco, Marta" sort="Fiocco, Marta" uniqKey="Fiocco M" first="Marta" last="Fiocco">Marta Fiocco</name><affiliation><nlm:affiliation>Department of Medical Statistics, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Euvrard, Sylvie" sort="Euvrard, Sylvie" uniqKey="Euvrard S" first="Sylvie" last="Euvrard">Sylvie Euvrard</name><affiliation><nlm:affiliation>Department of Dermatology, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Harwood, Catherine A" sort="Harwood, Catherine A" uniqKey="Harwood C" first="Catherine A" last="Harwood">Catherine A. Harwood</name><affiliation><nlm:affiliation>Centre for Cutaneous Research, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Proby, Charlotte M" sort="Proby, Charlotte M" uniqKey="Proby C" first="Charlotte M" last="Proby">Charlotte M. Proby</name><affiliation><nlm:affiliation>Division of Cancer Research, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Naldi, Luigi" sort="Naldi, Luigi" uniqKey="Naldi L" first="Luigi" last="Naldi">Luigi Naldi</name><affiliation><nlm:affiliation>Department of Dermatology, Azienda Ospedaliera papa Giovanni XXIII, GISED Study Center Bergamo, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Diphoorn, Janouk C D" sort="Diphoorn, Janouk C D" uniqKey="Diphoorn J" first="Janouk C D" last="Diphoorn">Janouk C D. Diphoorn</name><affiliation><nlm:affiliation>Department of Dermatology, Azienda Ospedaliera papa Giovanni XXIII, GISED Study Center Bergamo, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Venturuzzo, Anna" sort="Venturuzzo, Anna" uniqKey="Venturuzzo A" first="Anna" last="Venturuzzo">Anna Venturuzzo</name><affiliation><nlm:affiliation>Department of Dermatology, Azienda Ospedaliera papa Giovanni XXIII, GISED Study Center Bergamo, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Tessari, Gianpaolo" sort="Tessari, Gianpaolo" uniqKey="Tessari G" first="Gianpaolo" last="Tessari">Gianpaolo Tessari</name><affiliation><nlm:affiliation>Department of Biomedical and Surgical Sciences, Section of Dermatology, University of Verona, c/o Ospedale Civile Maggiore, Verona, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Nindl, Ingo" sort="Nindl, Ingo" uniqKey="Nindl I" first="Ingo" last="Nindl">Ingo Nindl</name><affiliation><nlm:affiliation>Department of Dermatology, University Hospital Charité, Skin Cancer Center Charité, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Sampogna, Francesca" sort="Sampogna, Francesca" uniqKey="Sampogna F" first="Francesca" last="Sampogna">Francesca Sampogna</name><affiliation><nlm:affiliation>Clinical Epidemiology Unit, IDI-IRCCS FLMM, Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Abeni, Damiano" sort="Abeni, Damiano" uniqKey="Abeni D" first="Damiano" last="Abeni">Damiano Abeni</name><affiliation><nlm:affiliation>Clinical Epidemiology Unit, IDI-IRCCS FLMM, Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Neale, Rachel E" sort="Neale, Rachel E" uniqKey="Neale R" first="Rachel E" last="Neale">Rachel E. Neale</name><affiliation><nlm:affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Goeman, Jelle J" sort="Goeman, Jelle J" uniqKey="Goeman J" first="Jelle J" last="Goeman">Jelle J. Goeman</name><affiliation><nlm:affiliation>Department of Medical Statistics, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Quint, Koen D" sort="Quint, Koen D" uniqKey="Quint K" first="Koen D" last="Quint">Koen D. Quint</name><affiliation><nlm:affiliation>Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Halk, Anne Berthe" sort="Halk, Anne Berthe" uniqKey="Halk A" first="Anne Berthe" last="Halk">Anne Berthe Halk</name><affiliation><nlm:affiliation>Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Sneek, Carmen" sort="Sneek, Carmen" uniqKey="Sneek C" first="Carmen" last="Sneek">Carmen Sneek</name><affiliation><nlm:affiliation>Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Genders, Roel E" sort="Genders, Roel E" uniqKey="Genders R" first="Roel E" last="Genders">Roel E. Genders</name><affiliation><nlm:affiliation>Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="De Koning, Maurits N C" sort="De Koning, Maurits N C" uniqKey="De Koning M" first="Maurits N C" last="De Koning">Maurits N C. De Koning</name><affiliation><nlm:affiliation>DDL Diagnostic Laboratory, Rijswijk, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Quint, Wim G V" sort="Quint, Wim G V" uniqKey="Quint W" first="Wim G V" last="Quint">Wim G V. Quint</name><affiliation><nlm:affiliation>DDL Diagnostic Laboratory, Rijswijk, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Wieland, Ulrike" sort="Wieland, Ulrike" uniqKey="Wieland U" first="Ulrike" last="Wieland">Ulrike Wieland</name><affiliation><nlm:affiliation>Institute of Virology, University of Cologne, Cologne, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Weissenborn, Sonke" sort="Weissenborn, Sonke" uniqKey="Weissenborn S" first="Sönke" last="Weissenborn">Sönke Weissenborn</name><affiliation><nlm:affiliation>Institute of Virology, University of Cologne, Cologne, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Waterboer, Tim" sort="Waterboer, Tim" uniqKey="Waterboer T" first="Tim" last="Waterboer">Tim Waterboer</name><affiliation><nlm:affiliation>German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Pawlita, Michael" sort="Pawlita, Michael" uniqKey="Pawlita M" first="Michael" last="Pawlita">Michael Pawlita</name><affiliation><nlm:affiliation>German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Pfister, Herbert" sort="Pfister, Herbert" uniqKey="Pfister H" first="Herbert" last="Pfister">Herbert Pfister</name><affiliation><nlm:affiliation>Institute of Virology, University of Cologne, Cologne, Germany.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:29024374</idno><idno type="pmid">29024374</idno><idno type="doi">10.1111/ajt.14537</idno><idno type="wicri:Area/PubMed/Corpus">000267</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000267</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Human papillomavirus and post-transplant cutaneous squamous-cell carcinoma: a multicenter, prospective cohort study.</title><author><name sortKey="Bouwes Bavinck, Jan Nico" sort="Bouwes Bavinck, Jan Nico" uniqKey="Bouwes Bavinck J" first="Jan Nico" last="Bouwes Bavinck">Jan Nico Bouwes Bavinck</name><affiliation><nlm:affiliation>Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Feltkamp, Mariet C W" sort="Feltkamp, Mariet C W" uniqKey="Feltkamp M" first="Mariet C W" last="Feltkamp">Mariet C W. Feltkamp</name><affiliation><nlm:affiliation>Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Green, Adele C" sort="Green, Adele C" uniqKey="Green A" first="Adele C" last="Green">Adele C. Green</name><affiliation><nlm:affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Fiocco, Marta" sort="Fiocco, Marta" uniqKey="Fiocco M" first="Marta" last="Fiocco">Marta Fiocco</name><affiliation><nlm:affiliation>Department of Medical Statistics, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Euvrard, Sylvie" sort="Euvrard, Sylvie" uniqKey="Euvrard S" first="Sylvie" last="Euvrard">Sylvie Euvrard</name><affiliation><nlm:affiliation>Department of Dermatology, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Harwood, Catherine A" sort="Harwood, Catherine A" uniqKey="Harwood C" first="Catherine A" last="Harwood">Catherine A. Harwood</name><affiliation><nlm:affiliation>Centre for Cutaneous Research, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Proby, Charlotte M" sort="Proby, Charlotte M" uniqKey="Proby C" first="Charlotte M" last="Proby">Charlotte M. Proby</name><affiliation><nlm:affiliation>Division of Cancer Research, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Naldi, Luigi" sort="Naldi, Luigi" uniqKey="Naldi L" first="Luigi" last="Naldi">Luigi Naldi</name><affiliation><nlm:affiliation>Department of Dermatology, Azienda Ospedaliera papa Giovanni XXIII, GISED Study Center Bergamo, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Diphoorn, Janouk C D" sort="Diphoorn, Janouk C D" uniqKey="Diphoorn J" first="Janouk C D" last="Diphoorn">Janouk C D. Diphoorn</name><affiliation><nlm:affiliation>Department of Dermatology, Azienda Ospedaliera papa Giovanni XXIII, GISED Study Center Bergamo, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Venturuzzo, Anna" sort="Venturuzzo, Anna" uniqKey="Venturuzzo A" first="Anna" last="Venturuzzo">Anna Venturuzzo</name><affiliation><nlm:affiliation>Department of Dermatology, Azienda Ospedaliera papa Giovanni XXIII, GISED Study Center Bergamo, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Tessari, Gianpaolo" sort="Tessari, Gianpaolo" uniqKey="Tessari G" first="Gianpaolo" last="Tessari">Gianpaolo Tessari</name><affiliation><nlm:affiliation>Department of Biomedical and Surgical Sciences, Section of Dermatology, University of Verona, c/o Ospedale Civile Maggiore, Verona, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Nindl, Ingo" sort="Nindl, Ingo" uniqKey="Nindl I" first="Ingo" last="Nindl">Ingo Nindl</name><affiliation><nlm:affiliation>Department of Dermatology, University Hospital Charité, Skin Cancer Center Charité, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Sampogna, Francesca" sort="Sampogna, Francesca" uniqKey="Sampogna F" first="Francesca" last="Sampogna">Francesca Sampogna</name><affiliation><nlm:affiliation>Clinical Epidemiology Unit, IDI-IRCCS FLMM, Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Abeni, Damiano" sort="Abeni, Damiano" uniqKey="Abeni D" first="Damiano" last="Abeni">Damiano Abeni</name><affiliation><nlm:affiliation>Clinical Epidemiology Unit, IDI-IRCCS FLMM, Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Neale, Rachel E" sort="Neale, Rachel E" uniqKey="Neale R" first="Rachel E" last="Neale">Rachel E. Neale</name><affiliation><nlm:affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Goeman, Jelle J" sort="Goeman, Jelle J" uniqKey="Goeman J" first="Jelle J" last="Goeman">Jelle J. Goeman</name><affiliation><nlm:affiliation>Department of Medical Statistics, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Quint, Koen D" sort="Quint, Koen D" uniqKey="Quint K" first="Koen D" last="Quint">Koen D. Quint</name><affiliation><nlm:affiliation>Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Halk, Anne Berthe" sort="Halk, Anne Berthe" uniqKey="Halk A" first="Anne Berthe" last="Halk">Anne Berthe Halk</name><affiliation><nlm:affiliation>Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Sneek, Carmen" sort="Sneek, Carmen" uniqKey="Sneek C" first="Carmen" last="Sneek">Carmen Sneek</name><affiliation><nlm:affiliation>Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Genders, Roel E" sort="Genders, Roel E" uniqKey="Genders R" first="Roel E" last="Genders">Roel E. Genders</name><affiliation><nlm:affiliation>Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="De Koning, Maurits N C" sort="De Koning, Maurits N C" uniqKey="De Koning M" first="Maurits N C" last="De Koning">Maurits N C. De Koning</name><affiliation><nlm:affiliation>DDL Diagnostic Laboratory, Rijswijk, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Quint, Wim G V" sort="Quint, Wim G V" uniqKey="Quint W" first="Wim G V" last="Quint">Wim G V. Quint</name><affiliation><nlm:affiliation>DDL Diagnostic Laboratory, Rijswijk, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Wieland, Ulrike" sort="Wieland, Ulrike" uniqKey="Wieland U" first="Ulrike" last="Wieland">Ulrike Wieland</name><affiliation><nlm:affiliation>Institute of Virology, University of Cologne, Cologne, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Weissenborn, Sonke" sort="Weissenborn, Sonke" uniqKey="Weissenborn S" first="Sönke" last="Weissenborn">Sönke Weissenborn</name><affiliation><nlm:affiliation>Institute of Virology, University of Cologne, Cologne, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Waterboer, Tim" sort="Waterboer, Tim" uniqKey="Waterboer T" first="Tim" last="Waterboer">Tim Waterboer</name><affiliation><nlm:affiliation>German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Pawlita, Michael" sort="Pawlita, Michael" uniqKey="Pawlita M" first="Michael" last="Pawlita">Michael Pawlita</name><affiliation><nlm:affiliation>German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Pfister, Herbert" sort="Pfister, Herbert" uniqKey="Pfister H" first="Herbert" last="Pfister">Herbert Pfister</name><affiliation><nlm:affiliation>Institute of Virology, University of Cologne, Cologne, Germany.</nlm:affiliation></affiliation></author></analytic><series><title level="j">American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</title><idno type="eISSN">1600-6143</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Organ-transplant recipients (OTR) have a 100-fold increased risk of cutaneous squamous-cell carcinoma (cSCC). We prospectively evaluated the association between beta-genus human-papillomaviruses (betaPV) and keratinocyte carcinoma in OTR. Two OTR cohorts without cSCC were assembled: cohort 1 transplanted in 2003-2006 (n=274) and cohort 2 in 1986-2002 (n=352). Participants were followed until death or cessation of follow-up in 2016. BetaPV infection was assessed in eyebrow hairs using PCR-based methods. BetaPV IgG seroresponses were determined by multiplex serology. A competing risk model with delayed entry was used to estimate cumulative incidence of histologically proven cSCC and the effect of betaPV using a multivariable Cox regression model. Results are reported as adjusted hazard ratios (HR). OTR with ≥5 different betaPV types in eyebrow hairs had 1.7 times the risk of cSCC versus those with 0-4 different types (HR: 1.7 (1.1;2.6)). A similar risk was seen with high betaPV loads (HR: 1.8 (1.2;2.8)). No significant associations were seen between serum antibodies and cSCC or between betaPV and basal-cell carcinoma. The diversity and load of betaPV types in eyebrow hairs are associated with cSCC risk in OTR, providing evidence that betaPV is associated with cSCC carcinogenesis and may present a target for future preventive strategies. This article is protected by copyright. All rights reserved.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">29024374</PMID><DateCreated><Year>2017</Year><Month>10</Month><Day>12</Day></DateCreated><DateRevised><Year>2017</Year><Month>10</Month><Day>12</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1600-6143</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2017</Year><Month>Oct</Month><Day>11</Day></PubDate></JournalIssue><Title>American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</Title><ISOAbbreviation>Am. J. Transplant.</ISOAbbreviation></Journal><ArticleTitle>Human papillomavirus and post-transplant cutaneous squamous-cell carcinoma: a multicenter, prospective cohort study.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1111/ajt.14537</ELocationID><Abstract><AbstractText>Organ-transplant recipients (OTR) have a 100-fold increased risk of cutaneous squamous-cell carcinoma (cSCC). We prospectively evaluated the association between beta-genus human-papillomaviruses (betaPV) and keratinocyte carcinoma in OTR. Two OTR cohorts without cSCC were assembled: cohort 1 transplanted in 2003-2006 (n=274) and cohort 2 in 1986-2002 (n=352). Participants were followed until death or cessation of follow-up in 2016. BetaPV infection was assessed in eyebrow hairs using PCR-based methods. BetaPV IgG seroresponses were determined by multiplex serology. A competing risk model with delayed entry was used to estimate cumulative incidence of histologically proven cSCC and the effect of betaPV using a multivariable Cox regression model. Results are reported as adjusted hazard ratios (HR). OTR with ≥5 different betaPV types in eyebrow hairs had 1.7 times the risk of cSCC versus those with 0-4 different types (HR: 1.7 (1.1;2.6)). A similar risk was seen with high betaPV loads (HR: 1.8 (1.2;2.8)). No significant associations were seen between serum antibodies and cSCC or between betaPV and basal-cell carcinoma. The diversity and load of betaPV types in eyebrow hairs are associated with cSCC risk in OTR, providing evidence that betaPV is associated with cSCC carcinogenesis and may present a target for future preventive strategies. This article is protected by copyright. All rights reserved.</AbstractText><CopyrightInformation>This article is protected by copyright. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bouwes Bavinck</LastName><ForeName>Jan Nico</ForeName><Initials>JN</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Feltkamp</LastName><ForeName>Mariet C W</ForeName><Initials>MCW</Initials><AffiliationInfo><Affiliation>Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Green</LastName><ForeName>Adele C</ForeName><Initials>AC</Initials><AffiliationInfo><Affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fiocco</LastName><ForeName>Marta</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medical Statistics, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Mathematics, Leiden University, Leiden, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Euvrard</LastName><ForeName>Sylvie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Harwood</LastName><ForeName>Catherine A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Centre for Cutaneous Research, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Proby</LastName><ForeName>Charlotte M</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>Division of Cancer Research, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Naldi</LastName><ForeName>Luigi</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Azienda Ospedaliera papa Giovanni XXIII, GISED Study Center Bergamo, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Diphoorn</LastName><ForeName>Janouk C D</ForeName><Initials>JCD</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Azienda Ospedaliera papa Giovanni XXIII, GISED Study Center Bergamo, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Venturuzzo</LastName><ForeName>Anna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Azienda Ospedaliera papa Giovanni XXIII, GISED Study Center Bergamo, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tessari</LastName><ForeName>Gianpaolo</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Biomedical and Surgical Sciences, Section of Dermatology, University of Verona, c/o Ospedale Civile Maggiore, Verona, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nindl</LastName><ForeName>Ingo</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Dermatology, University Hospital Charité, Skin Cancer Center Charité, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sampogna</LastName><ForeName>Francesca</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Clinical Epidemiology Unit, IDI-IRCCS FLMM, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abeni</LastName><ForeName>Damiano</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Clinical Epidemiology Unit, IDI-IRCCS FLMM, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Neale</LastName><ForeName>Rachel E</ForeName><Initials>RE</Initials><AffiliationInfo><Affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goeman</LastName><ForeName>Jelle J</ForeName><Initials>JJ</Initials><AffiliationInfo><Affiliation>Department of Medical Statistics, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Quint</LastName><ForeName>Koen D</ForeName><Initials>KD</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Halk</LastName><ForeName>Anne Berthe</ForeName><Initials>AB</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sneek</LastName><ForeName>Carmen</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Genders</LastName><ForeName>Roel E</ForeName><Initials>RE</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Koning</LastName><ForeName>Maurits N C</ForeName><Initials>MNC</Initials><AffiliationInfo><Affiliation>DDL Diagnostic Laboratory, Rijswijk, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Quint</LastName><ForeName>Wim G V</ForeName><Initials>WGV</Initials><AffiliationInfo><Affiliation>DDL Diagnostic Laboratory, Rijswijk, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wieland</LastName><ForeName>Ulrike</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Institute of Virology, University of Cologne, Cologne, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weissenborn</LastName><ForeName>Sönke</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute of Virology, University of Cologne, Cologne, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Waterboer</LastName><ForeName>Tim</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pawlita</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pfister</LastName><ForeName>Herbert</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Institute of Virology, University of Cologne, Cologne, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>EPI-HPV-UV-CA group</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>10</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Transplant</MedlineTA><NlmUniqueID>100968638</NlmUniqueID><ISSNLinking>1600-6135</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>10</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>10</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>10</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29024374</ArticleId><ArticleId IdType="doi">10.1111/ajt.14537</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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