Integrative Analysis of Immunological Data to Explore Chronic Immune T-Cell Activation in Successfully Treated HIV Patients.
Identifieur interne : 000969 ( PubMed/Checkpoint ); précédent : 000968; suivant : 000970Integrative Analysis of Immunological Data to Explore Chronic Immune T-Cell Activation in Successfully Treated HIV Patients.
Auteurs : Marie-Quitterie Picat [France] ; Isabelle Pellegrin [France] ; Juliette Bitard [France] ; Linda Wittkop [France] ; Cécile Proust-Lima [France] ; Benoît Liquet [France] ; Jean-François Moreau [France] ; Fabrice Bonnet [France] ; Patrick Blanco [France] ; Rodolphe Thiébaut [France]Source :
- PloS one [ 1932-6203 ] ; 2017.
Descripteurs français
- KwdFr :
- ARN ribosomique 16S (métabolisme), Activation des lymphocytes, Adulte, Adulte d'âge moyen, Algorithmes, Analyse multivariée, Antigènes CD38 (métabolisme), Antigènes HLA-DR (métabolisme), Antirétroviraux (usage thérapeutique), Auto-immunité (immunologie), Cytomegalovirus, Facteurs de risque, Femelle, France, Humains, Infections à VIH (), Infections à VIH (immunologie), Interféron alpha (immunologie), Lymphocytes T (immunologie), Lymphocytes T CD4+ (immunologie), Lymphocytes T CD8+ (immunologie), Maladie chronique, Modèles statistiques, Mâle, Études de cohortes, Études transversales.
- MESH :
- immunologie : Auto-immunité, Infections à VIH, Interféron alpha, Lymphocytes T, Lymphocytes T CD4+, Lymphocytes T CD8+.
- métabolisme : ARN ribosomique 16S, Antigènes CD38, Antigènes HLA-DR.
- usage thérapeutique : Antirétroviraux.
- Activation des lymphocytes, Adulte, Adulte d'âge moyen, Algorithmes, Analyse multivariée, Cytomegalovirus, Facteurs de risque, Femelle, France, Humains, Infections à VIH, Maladie chronique, Modèles statistiques, Mâle, Études de cohortes, Études transversales.
English descriptors
- KwdEn :
- Adult, Algorithms, Anti-Retroviral Agents (therapeutic use), Antigens, CD38 (metabolism), Autoimmunity (immunology), CD4-Positive T-Lymphocytes (immunology), CD8-Positive T-Lymphocytes (immunology), Chronic Disease, Cohort Studies, Cross-Sectional Studies, Cytomegalovirus, Female, France, HIV Infections (immunology), HIV Infections (therapy), HLA-DR Antigens (metabolism), Humans, Interferon-alpha (immunology), Lymphocyte Activation, Male, Middle Aged, Models, Statistical, Multivariate Analysis, RNA, Ribosomal, 16S (metabolism), Risk Factors, T-Lymphocytes (immunology).
- MESH :
- chemical , immunology : Interferon-alpha.
- chemical , metabolism : Antigens, CD38, HLA-DR Antigens, RNA, Ribosomal, 16S.
- chemical , therapeutic use : Anti-Retroviral Agents.
- immunology : Autoimmunity, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, HIV Infections, T-Lymphocytes.
- therapy : HIV Infections.
- Adult, Algorithms, Chronic Disease, Cohort Studies, Cross-Sectional Studies, Cytomegalovirus, Female, France, Humans, Lymphocyte Activation, Male, Middle Aged, Models, Statistical, Multivariate Analysis, Risk Factors.
Abstract
To unravel the complex relationships between cytomegalovirus-induced-, autoimmune-induced responses, microbial translocation and chronic immune activation (CIA) in successfully treated HIV-infected patients and to explore the mediating role of alpha-interferon in these processes.
DOI: 10.1371/journal.pone.0169164
PubMed: 28046052
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:28046052Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Integrative Analysis of Immunological Data to Explore Chronic Immune T-Cell Activation in Successfully Treated HIV Patients.</title>
<author><name sortKey="Picat, Marie Quitterie" sort="Picat, Marie Quitterie" uniqKey="Picat M" first="Marie-Quitterie" last="Picat">Marie-Quitterie Picat</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre INSERM U1219 Bordeaux Population Health, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pellegrin, Isabelle" sort="Pellegrin, Isabelle" uniqKey="Pellegrin I" first="Isabelle" last="Pellegrin">Isabelle Pellegrin</name>
<affiliation wicri:level="3"><nlm:affiliation>Laboratoire d'Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire d'Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bitard, Juliette" sort="Bitard, Juliette" uniqKey="Bitard J" first="Juliette" last="Bitard">Juliette Bitard</name>
<affiliation wicri:level="3"><nlm:affiliation>Laboratoire d'Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire d'Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wittkop, Linda" sort="Wittkop, Linda" uniqKey="Wittkop L" first="Linda" last="Wittkop">Linda Wittkop</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre INSERM U1219 Bordeaux Population Health, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Proust Lima, Cecile" sort="Proust Lima, Cecile" uniqKey="Proust Lima C" first="Cécile" last="Proust-Lima">Cécile Proust-Lima</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre INSERM U1219 Bordeaux Population Health, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liquet, Benoit" sort="Liquet, Benoit" uniqKey="Liquet B" first="Benoît" last="Liquet">Benoît Liquet</name>
<affiliation wicri:level="3"><nlm:affiliation>Laboratoire de Mathématiques et de leurs Applications, Université de Pau et des Pays de l'Adour, UMR CNRS 5142, Pau, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Mathématiques et de leurs Applications, Université de Pau et des Pays de l'Adour, UMR CNRS 5142, Pau</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Pau</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Moreau, Jean Francois" sort="Moreau, Jean Francois" uniqKey="Moreau J" first="Jean-François" last="Moreau">Jean-François Moreau</name>
<affiliation wicri:level="3"><nlm:affiliation>Laboratoire d'Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire d'Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bonnet, Fabrice" sort="Bonnet, Fabrice" uniqKey="Bonnet F" first="Fabrice" last="Bonnet">Fabrice Bonnet</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre INSERM U1219 Bordeaux Population Health, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Blanco, Patrick" sort="Blanco, Patrick" uniqKey="Blanco P" first="Patrick" last="Blanco">Patrick Blanco</name>
<affiliation wicri:level="3"><nlm:affiliation>Laboratoire d'Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire d'Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thiebaut, Rodolphe" sort="Thiebaut, Rodolphe" uniqKey="Thiebaut R" first="Rodolphe" last="Thiébaut">Rodolphe Thiébaut</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre INSERM U1219 Bordeaux Population Health, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2017">2017</date>
<idno type="RBID">pubmed:28046052</idno>
<idno type="pmid">28046052</idno>
<idno type="doi">10.1371/journal.pone.0169164</idno>
<idno type="wicri:Area/PubMed/Corpus">001236</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001236</idno>
<idno type="wicri:Area/PubMed/Curation">001225</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001225</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001225</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001225</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Integrative Analysis of Immunological Data to Explore Chronic Immune T-Cell Activation in Successfully Treated HIV Patients.</title>
<author><name sortKey="Picat, Marie Quitterie" sort="Picat, Marie Quitterie" uniqKey="Picat M" first="Marie-Quitterie" last="Picat">Marie-Quitterie Picat</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre INSERM U1219 Bordeaux Population Health, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pellegrin, Isabelle" sort="Pellegrin, Isabelle" uniqKey="Pellegrin I" first="Isabelle" last="Pellegrin">Isabelle Pellegrin</name>
<affiliation wicri:level="3"><nlm:affiliation>Laboratoire d'Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire d'Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bitard, Juliette" sort="Bitard, Juliette" uniqKey="Bitard J" first="Juliette" last="Bitard">Juliette Bitard</name>
<affiliation wicri:level="3"><nlm:affiliation>Laboratoire d'Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire d'Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wittkop, Linda" sort="Wittkop, Linda" uniqKey="Wittkop L" first="Linda" last="Wittkop">Linda Wittkop</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre INSERM U1219 Bordeaux Population Health, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Proust Lima, Cecile" sort="Proust Lima, Cecile" uniqKey="Proust Lima C" first="Cécile" last="Proust-Lima">Cécile Proust-Lima</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre INSERM U1219 Bordeaux Population Health, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liquet, Benoit" sort="Liquet, Benoit" uniqKey="Liquet B" first="Benoît" last="Liquet">Benoît Liquet</name>
<affiliation wicri:level="3"><nlm:affiliation>Laboratoire de Mathématiques et de leurs Applications, Université de Pau et des Pays de l'Adour, UMR CNRS 5142, Pau, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Mathématiques et de leurs Applications, Université de Pau et des Pays de l'Adour, UMR CNRS 5142, Pau</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Pau</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Moreau, Jean Francois" sort="Moreau, Jean Francois" uniqKey="Moreau J" first="Jean-François" last="Moreau">Jean-François Moreau</name>
<affiliation wicri:level="3"><nlm:affiliation>Laboratoire d'Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire d'Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bonnet, Fabrice" sort="Bonnet, Fabrice" uniqKey="Bonnet F" first="Fabrice" last="Bonnet">Fabrice Bonnet</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre INSERM U1219 Bordeaux Population Health, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Blanco, Patrick" sort="Blanco, Patrick" uniqKey="Blanco P" first="Patrick" last="Blanco">Patrick Blanco</name>
<affiliation wicri:level="3"><nlm:affiliation>Laboratoire d'Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire d'Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thiebaut, Rodolphe" sort="Thiebaut, Rodolphe" uniqKey="Thiebaut R" first="Rodolphe" last="Thiébaut">Rodolphe Thiébaut</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre INSERM U1219 Bordeaux Population Health, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">PloS one</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Algorithms</term>
<term>Anti-Retroviral Agents (therapeutic use)</term>
<term>Antigens, CD38 (metabolism)</term>
<term>Autoimmunity (immunology)</term>
<term>CD4-Positive T-Lymphocytes (immunology)</term>
<term>CD8-Positive T-Lymphocytes (immunology)</term>
<term>Chronic Disease</term>
<term>Cohort Studies</term>
<term>Cross-Sectional Studies</term>
<term>Cytomegalovirus</term>
<term>Female</term>
<term>France</term>
<term>HIV Infections (immunology)</term>
<term>HIV Infections (therapy)</term>
<term>HLA-DR Antigens (metabolism)</term>
<term>Humans</term>
<term>Interferon-alpha (immunology)</term>
<term>Lymphocyte Activation</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Models, Statistical</term>
<term>Multivariate Analysis</term>
<term>RNA, Ribosomal, 16S (metabolism)</term>
<term>Risk Factors</term>
<term>T-Lymphocytes (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN ribosomique 16S (métabolisme)</term>
<term>Activation des lymphocytes</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Algorithmes</term>
<term>Analyse multivariée</term>
<term>Antigènes CD38 (métabolisme)</term>
<term>Antigènes HLA-DR (métabolisme)</term>
<term>Antirétroviraux (usage thérapeutique)</term>
<term>Auto-immunité (immunologie)</term>
<term>Cytomegalovirus</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>France</term>
<term>Humains</term>
<term>Infections à VIH ()</term>
<term>Infections à VIH (immunologie)</term>
<term>Interféron alpha (immunologie)</term>
<term>Lymphocytes T (immunologie)</term>
<term>Lymphocytes T CD4+ (immunologie)</term>
<term>Lymphocytes T CD8+ (immunologie)</term>
<term>Maladie chronique</term>
<term>Modèles statistiques</term>
<term>Mâle</term>
<term>Études de cohortes</term>
<term>Études transversales</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Interferon-alpha</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antigens, CD38</term>
<term>HLA-DR Antigens</term>
<term>RNA, Ribosomal, 16S</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Retroviral Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Auto-immunité</term>
<term>Infections à VIH</term>
<term>Interféron alpha</term>
<term>Lymphocytes T</term>
<term>Lymphocytes T CD4+</term>
<term>Lymphocytes T CD8+</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Autoimmunity</term>
<term>CD4-Positive T-Lymphocytes</term>
<term>CD8-Positive T-Lymphocytes</term>
<term>HIV Infections</term>
<term>T-Lymphocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ARN ribosomique 16S</term>
<term>Antigènes CD38</term>
<term>Antigènes HLA-DR</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>HIV Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antirétroviraux</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Algorithms</term>
<term>Chronic Disease</term>
<term>Cohort Studies</term>
<term>Cross-Sectional Studies</term>
<term>Cytomegalovirus</term>
<term>Female</term>
<term>France</term>
<term>Humans</term>
<term>Lymphocyte Activation</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Models, Statistical</term>
<term>Multivariate Analysis</term>
<term>Risk Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Activation des lymphocytes</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Algorithmes</term>
<term>Analyse multivariée</term>
<term>Cytomegalovirus</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>France</term>
<term>Humains</term>
<term>Infections à VIH</term>
<term>Maladie chronique</term>
<term>Modèles statistiques</term>
<term>Mâle</term>
<term>Études de cohortes</term>
<term>Études transversales</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">To unravel the complex relationships between cytomegalovirus-induced-, autoimmune-induced responses, microbial translocation and chronic immune activation (CIA) in successfully treated HIV-infected patients and to explore the mediating role of alpha-interferon in these processes.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28046052</PMID>
<DateCreated><Year>2017</Year>
<Month>01</Month>
<Day>03</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>09</Month>
<Day>06</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>11</Month>
<Day>16</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>12</Volume>
<Issue>1</Issue>
<PubDate><Year>2017</Year>
</PubDate>
</JournalIssue>
<Title>PloS one</Title>
<ISOAbbreviation>PLoS ONE</ISOAbbreviation>
</Journal>
<ArticleTitle>Integrative Analysis of Immunological Data to Explore Chronic Immune T-Cell Activation in Successfully Treated HIV Patients.</ArticleTitle>
<Pagination><MedlinePgn>e0169164</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0169164</ELocationID>
<Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To unravel the complex relationships between cytomegalovirus-induced-, autoimmune-induced responses, microbial translocation and chronic immune activation (CIA) in successfully treated HIV-infected patients and to explore the mediating role of alpha-interferon in these processes.</AbstractText>
<AbstractText Label="DESIGN" NlmCategory="METHODS">Cross-sectional study nested in the ANRS CO3 Aquitaine Cohort, a prospective hospital-based cohort of HIV-1-infected patients in South-Western France.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Patients initiated antiretroviral therapy between 2005 and 2008 and were treated with sustained virological suppression for at least two years. CIA was defined by the percentage of HLA-DR+/CD38+ among CD8+T-cells. Integrative analyses were performed using structural equation modelling (SEM).</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The main analysis was performed in 57 HLA-A*0201 positive patients, due to availability of percentages of actin-, vimentin-, lamin-specific CD8+T-cells (HLA-A2-restricted tests) to further characterize autoimmune response. Cytomegalovirus-induced response was assessed by Quantiferon and pp-65 ELISPOT. SEM revealed a direct effect of cytomegalovirus-induced response on CIA (standardized estimate βstd = 0.56, p-value = 0.0004). The effect of autoimmune-induced response on CIA was indirect through alpha-interferon pathway, assessed by expression levels of 5 alpha-interferon-stimulated genes ADAR, ISG15, IFIT1, Mx1 and OAS1 (effect of autoimmune response on alpha-interferon: βstd = 0.36, p-value = 0.0401; effect of alpha-interferon on CIA: βstd = 0.39, p-value = 0.0044). There was no direct effect of autoimmune-induced response on CIA (p-value = 0.3169). Microbial translocation as measured by 16SrDNA and sCD14 in plasma was not associated with CIA. Results were consistent in 142 patients in whom cytomegalovirus and auto-immunity responses were measured by Quantiferon and anti-nuclear antibodies, respectively. All analyses performed in HLA-A*0201 positive patients and in the overall population revealed a significant effect of IFN-α latent variable on CIA.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The role of cytomegalovirus-induced response on CIA was confirmed as well as the involvement of alpha-interferon on CIA. The indirect effect of auto-immunity response on CIA revealed through the alpha-interferon pathway requires further investigation to confirm the potential role of auto-immunity for CIA in HIV-infected patients.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Picat</LastName>
<ForeName>Marie-Quitterie</ForeName>
<Initials>MQ</Initials>
<AffiliationInfo><Affiliation>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Univ. Bordeaux, ISPED, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Service d'Information Médicale, USMR, CHU de Bordeaux - Pôle de Santé Publique, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>INRIA, Team SISTM, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Vaccine Research Institute-VRI, Hôpital Henri Mondor, Créteil, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pellegrin</LastName>
<ForeName>Isabelle</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Laboratoire d'Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bitard</LastName>
<ForeName>Juliette</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Laboratoire d'Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wittkop</LastName>
<ForeName>Linda</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Univ. Bordeaux, ISPED, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Service d'Information Médicale, USMR, CHU de Bordeaux - Pôle de Santé Publique, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>INRIA, Team SISTM, Bordeaux, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Proust-Lima</LastName>
<ForeName>Cécile</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Univ. Bordeaux, ISPED, Bordeaux, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liquet</LastName>
<ForeName>Benoît</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Laboratoire de Mathématiques et de leurs Applications, Université de Pau et des Pays de l'Adour, UMR CNRS 5142, Pau, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>ARC Centre of Excellence for Mathematical and Statistical Frontiers, Queensland University of Technology (QUT), Brisbane, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Moreau</LastName>
<ForeName>Jean-François</ForeName>
<Initials>JF</Initials>
<AffiliationInfo><Affiliation>Laboratoire d'Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Univ. Bordeaux, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>CNRS, UMR 5164, Bordeaux, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bonnet</LastName>
<ForeName>Fabrice</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Univ. Bordeaux, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Service de Médecine Interne et maladies Infectieuses, CHU de Bordeaux, Bordeaux, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Blanco</LastName>
<ForeName>Patrick</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Laboratoire d'Immunologie-Immunogénétique, Pôle de Biologie, CHU Bordeaux, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Univ. Bordeaux, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>CNRS, UMR 5164, Bordeaux, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Thiébaut</LastName>
<ForeName>Rodolphe</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Centre INSERM U1219 Bordeaux Population Health, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Univ. Bordeaux, ISPED, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Service d'Information Médicale, USMR, CHU de Bordeaux - Pôle de Santé Publique, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>INRIA, Team SISTM, Bordeaux, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Vaccine Research Institute-VRI, Hôpital Henri Mondor, Créteil, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><CollectiveName>ANRS CO3 Aquitaine Cohort</CollectiveName>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2017</Year>
<Month>01</Month>
<Day>03</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>PLoS One</MedlineTA>
<NlmUniqueID>101285081</NlmUniqueID>
<ISSNLinking>1932-6203</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D044966">Anti-Retroviral Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D006684">HLA-DR Antigens</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016898">Interferon-alpha</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D012336">RNA, Ribosomal, 16S</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.2.2.5</RegistryNumber>
<NameOfSubstance UI="D051997">Antigens, CD38</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>BMC Immunol. 2007 Oct 26;8:27</RefSource>
<PMID Version="1">17963513</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Stat Methods Med Res. 2007 Oct;16(5):399-415</RefSource>
<PMID Version="1">17656454</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Science. 2013 Apr 12;340(6129):202-7</RefSource>
<PMID Version="1">23580528</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Virol. 2005 Apr;79(8):5027-34</RefSource>
<PMID Version="1">15795288</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Rev Immunol. 2014 Jan;14(1):36-49</RefSource>
<PMID Version="1">24362405</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Clin Transl Immunology. 2014 Feb 28;3(2):e10</RefSource>
<PMID Version="1">25505958</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>BMC Med Res Methodol. 2010 Apr 30;10:37</RefSource>
<PMID Version="1">20433707</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Curr Opin Virol. 2011 Dec;1(6):519-25</RefSource>
<PMID Version="1">22328912</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 2012 Jun;205 Suppl 3:S375-82</RefSource>
<PMID Version="1">22577211</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 2016 Oct 1;214 Suppl 2:S67-74</RefSource>
<PMID Version="1">27625433</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Virol. 2007 Aug;81(15):8180-91</RefSource>
<PMID Version="1">17507480</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2016 Feb 18;11(2):e0149327</RefSource>
<PMID Version="1">26889682</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Methods. 2001 Dec;25(4):402-8</RefSource>
<PMID Version="1">11846609</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Science. 2013 Apr 12;340(6129):207-11</RefSource>
<PMID Version="1">23580529</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS Pathog. 2013;9(7):e1003530</RefSource>
<PMID Version="1">23935491</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Acquir Immune Defic Syndr. 2013 Oct 1;64(2):149-53</RefSource>
<PMID Version="1">24047967</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>HIV Med. 2016 Feb;17 (2):89-105</RefSource>
<PMID Version="1">26452565</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 2011 May 15;203(10 ):1474-83</RefSource>
<PMID Version="1">21502083</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Clin Infect Dis. 2016 Feb 1;62(3):392-6</RefSource>
<PMID Version="1">26400999</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>AIDS Res Hum Retroviruses. 2012 May;28(5):469-77</RefSource>
<PMID Version="1">21854232</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 2012 Jun 15;205(12):1788-96</RefSource>
<PMID Version="1">22492856</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Eur J Epidemiol. 2013 Aug;28(8):677-88</RefSource>
<PMID Version="1">23532743</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Curr Opin Virol. 2016 Feb;16:63-9</RefSource>
<PMID Version="1">26855038</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2008 Apr 23;3(4):e2021</RefSource>
<PMID Version="1">18431498</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>AIDS. 2008 Feb 19;22(4):439-46</RefSource>
<PMID Version="1">18301056</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Pathol. 2008 Jan;214(2):231-41</RefSource>
<PMID Version="1">18161758</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arthritis Rheum. 2005 Jan;52(1):201-11</RefSource>
<PMID Version="1">15641052</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>BMC Immunol. 2016 May 20;17(1):11</RefSource>
<PMID Version="1">27206492</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Immunol Rev. 2013 Jul;254(1):78-101</RefSource>
<PMID Version="1">23772616</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>AIDS. 2013 May 15;27(8):1199-208</RefSource>
<PMID Version="1">23324661</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Obesity (Silver Spring). 2016 Feb;24(2):483-9</RefSource>
<PMID Version="1">26719030</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Parasit Vectors. 2015 Dec 23;8:658</RefSource>
<PMID Version="1">26701692</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cytokine Growth Factor Rev. 2008 Feb;19(1):41-52</RefSource>
<PMID Version="1">18258476</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mech Ageing Dev. 2016 Sep;158:46-52</RefSource>
<PMID Version="1">26404009</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Immunity. 2006 Sep;25(3):383-92</RefSource>
<PMID Version="1">16979570</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Infect Genet Evol. 2014 Jan;21:497-505</RefSource>
<PMID Version="1">24035791</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>BMC Bioinformatics. 2011 Aug 19;12:349</RefSource>
<PMID Version="1">21854615</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Immunology. 2014 Nov;143(3):319-30</RefSource>
<PMID Version="1">24965611</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arthritis Rheumatol. 2014 Dec;66(12):3359-70</RefSource>
<PMID Version="1">25306868</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>AIDS. 2005 Mar 24;19(6):555-62</RefSource>
<PMID Version="1">15802973</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>AIDS. 2000 May 26;14(8):971-8</RefSource>
<PMID Version="1">10853978</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Med. 2007 Dec;13(12):1431-9</RefSource>
<PMID Version="1">18026114</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Environ Health. 2015 Jun 05;14:47</RefSource>
<PMID Version="1">26041029</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Int J Epidemiol. 2009 Apr;38(2):538-48</RefSource>
<PMID Version="1">19039006</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Rev Immunol. 2004 Jul;4(7):499-511</RefSource>
<PMID Version="1">15229469</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Cytokine Growth Factor Rev. 2015 Apr;26(2):143-58</RefSource>
<PMID Version="1">25466629</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Blood. 2004 Aug 15;104(4):942-7</RefSource>
<PMID Version="1">15117761</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Med. 2006 Dec;12(12):1365-71</RefSource>
<PMID Version="1">17115046</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Trends Microbiol. 2013 Jan;21(1):6-13</RefSource>
<PMID Version="1">23062765</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2014 Feb 03;9(2):e87597</RefSource>
<PMID Version="1">24498339</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>AIDS. 2006 Nov 28;20(18):2275-83</RefSource>
<PMID Version="1">17117013</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Annu Rev Immunol. 2014;32:513-45</RefSource>
<PMID Version="1">24555472</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 2009 Apr 15;199(8):1177-85</RefSource>
<PMID Version="1">19265479</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>AIDS Res Hum Retroviruses. 2004 Feb;20(2):227-33</RefSource>
<PMID Version="1">15018711</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 2013 Feb 15;207(4):622-7</RefSource>
<PMID Version="1">23204178</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Clin Dev Immunol. 2012;2012:534929</RefSource>
<PMID Version="1">22203858</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Curr HIV/AIDS Rep. 2016 Feb;13(1):10-9</RefSource>
<PMID Version="1">26810437</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Curr Opin Infect Dis. 2009 Feb;22(1):49-56</RefSource>
<PMID Version="1">19532080</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Infect Dis. 2015 Jan 15;211(2):178-86</RefSource>
<PMID Version="1">25081936</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>AIDS. 2011 Sep 24;25(15):1813-22</RefSource>
<PMID Version="1">21412126</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000465" MajorTopicYN="N">Algorithms</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D044966" MajorTopicYN="N">Anti-Retroviral Agents</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051997" MajorTopicYN="N">Antigens, CD38</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015551" MajorTopicYN="N">Autoimmunity</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015496" MajorTopicYN="N">CD4-Positive T-Lymphocytes</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018414" MajorTopicYN="N">CD8-Positive T-Lymphocytes</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002908" MajorTopicYN="N">Chronic Disease</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003430" MajorTopicYN="N">Cross-Sectional Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003587" MajorTopicYN="N">Cytomegalovirus</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005602" MajorTopicYN="N">France</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015658" MajorTopicYN="N">HIV Infections</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006684" MajorTopicYN="N">HLA-DR Antigens</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016898" MajorTopicYN="N">Interferon-alpha</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008213" MajorTopicYN="Y">Lymphocyte Activation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015233" MajorTopicYN="N">Models, Statistical</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015999" MajorTopicYN="N">Multivariate Analysis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012336" MajorTopicYN="N">RNA, Ribosomal, 16S</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013601" MajorTopicYN="N">T-Lymphocytes</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
</MeshHeadingList>
<CoiStatement>The authors have declared that no competing interests exist.</CoiStatement>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year>
<Month>08</Month>
<Day>18</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>12</Month>
<Day>13</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2017</Year>
<Month>1</Month>
<Day>4</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2017</Year>
<Month>1</Month>
<Day>4</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2017</Year>
<Month>9</Month>
<Day>7</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>epublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">28046052</ArticleId>
<ArticleId IdType="doi">10.1371/journal.pone.0169164</ArticleId>
<ArticleId IdType="pii">PONE-D-16-33104</ArticleId>
<ArticleId IdType="pmc">PMC5207686</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>France</li>
</country>
<region><li>Aquitaine</li>
<li>Nouvelle-Aquitaine</li>
</region>
<settlement><li>Bordeaux</li>
<li>Pau</li>
</settlement>
</list>
<tree><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Picat, Marie Quitterie" sort="Picat, Marie Quitterie" uniqKey="Picat M" first="Marie-Quitterie" last="Picat">Marie-Quitterie Picat</name>
</region>
<name sortKey="Bitard, Juliette" sort="Bitard, Juliette" uniqKey="Bitard J" first="Juliette" last="Bitard">Juliette Bitard</name>
<name sortKey="Blanco, Patrick" sort="Blanco, Patrick" uniqKey="Blanco P" first="Patrick" last="Blanco">Patrick Blanco</name>
<name sortKey="Bonnet, Fabrice" sort="Bonnet, Fabrice" uniqKey="Bonnet F" first="Fabrice" last="Bonnet">Fabrice Bonnet</name>
<name sortKey="Liquet, Benoit" sort="Liquet, Benoit" uniqKey="Liquet B" first="Benoît" last="Liquet">Benoît Liquet</name>
<name sortKey="Moreau, Jean Francois" sort="Moreau, Jean Francois" uniqKey="Moreau J" first="Jean-François" last="Moreau">Jean-François Moreau</name>
<name sortKey="Pellegrin, Isabelle" sort="Pellegrin, Isabelle" uniqKey="Pellegrin I" first="Isabelle" last="Pellegrin">Isabelle Pellegrin</name>
<name sortKey="Proust Lima, Cecile" sort="Proust Lima, Cecile" uniqKey="Proust Lima C" first="Cécile" last="Proust-Lima">Cécile Proust-Lima</name>
<name sortKey="Thiebaut, Rodolphe" sort="Thiebaut, Rodolphe" uniqKey="Thiebaut R" first="Rodolphe" last="Thiébaut">Rodolphe Thiébaut</name>
<name sortKey="Wittkop, Linda" sort="Wittkop, Linda" uniqKey="Wittkop L" first="Linda" last="Wittkop">Linda Wittkop</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000969 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000969 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= PubMed |étape= Checkpoint |type= RBID |clé= pubmed:28046052 |texte= Integrative Analysis of Immunological Data to Explore Chronic Immune T-Cell Activation in Successfully Treated HIV Patients. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:28046052" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a AustralieFrV1
This area was generated with Dilib version V0.6.33. |