Longitudinal Assessment of the Effect of Atrasentan on Thoracic Bioimpedance in Diabetic Nephropathy: A Randomized, Double-Blind, Placebo-Controlled Trial.
Identifieur interne : 000867 ( PubMed/Checkpoint ); précédent : 000866; suivant : 000868Longitudinal Assessment of the Effect of Atrasentan on Thoracic Bioimpedance in Diabetic Nephropathy: A Randomized, Double-Blind, Placebo-Controlled Trial.
Auteurs : David J. Webb [Royaume-Uni] ; Blai Coll [États-Unis] ; Hiddo J L. Heerspink [Pays-Bas] ; Dennis Andress [États-Unis] ; Yili Pritchett [États-Unis] ; John J. Brennan [États-Unis] ; Mark Houser [États-Unis] ; Ricardo Correa-Rotter [Mexique] ; Donald Kohan [États-Unis] ; Hirofumi Makino [Japon] ; Vlado Perkovic [Australie] ; Giuseppe Remuzzi [Italie] ; Sheldon W. Tobe [Canada] ; Robert Toto [États-Unis] ; Robert Busch [États-Unis] ; Pablo Pergola [États-Unis] ; Hans-Henrik Parving [Danemark] ; Dick De Zeeuw [Pays-Bas]Source :
- Drugs in R&D [ 1179-6901 ] ; 2017.
Abstract
Fluid retention is a common adverse event in patients who receive endothelin (ET) receptor antagonist therapy, including the highly selective ETA receptor antagonist, atrasentan.
DOI: 10.1007/s40268-017-0201-0
PubMed: 28831752
Affiliations:
- Australie, Canada, Danemark, Italie, Japon, Mexique, Pays-Bas, Royaume-Uni, États-Unis
- Groningue (province), Hovedstaden, Illinois, Maryland, Nouvelle-Galles du Sud, Texas, Utah, Écosse, État de New York
- Copenhague, Groningue, Groningue (ville), Sydney, Édimbourg
- Université d'Édimbourg, Université de Groningue, Université de Sydney
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D.J.Webb@ed.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Edinburgh Hypertension Excellence Centre, Clinical Pharmacology Unit, University of Edinburgh, E3.22, QMRI, 47 Little France Crescent, Edinburgh, EH16 4TJ, Scotland</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Coll, Blai" sort="Coll, Blai" uniqKey="Coll B" first="Blai" last="Coll">Blai Coll</name><affiliation wicri:level="2"><nlm:affiliation>AbbVie, North Chicago, IL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>AbbVie, North Chicago, IL</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Heerspink, Hiddo J L" sort="Heerspink, Hiddo J L" uniqKey="Heerspink H" first="Hiddo J L" last="Heerspink">Hiddo J L. Heerspink</name><affiliation wicri:level="4"><nlm:affiliation>Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Centre Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region><settlement type="city">Groningue (ville)</settlement></placeName><orgName type="university">Université de Groningue</orgName></affiliation></author><author><name sortKey="Andress, Dennis" sort="Andress, Dennis" uniqKey="Andress D" first="Dennis" last="Andress">Dennis Andress</name><affiliation wicri:level="2"><nlm:affiliation>AbbVie, North Chicago, IL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>AbbVie, North Chicago, IL</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Pritchett, Yili" sort="Pritchett, Yili" uniqKey="Pritchett Y" first="Yili" last="Pritchett">Yili Pritchett</name><affiliation wicri:level="2"><nlm:affiliation>MedImmune, Gaithersburg, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>MedImmune, Gaithersburg, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Brennan, John J" sort="Brennan, John J" uniqKey="Brennan J" first="John J" last="Brennan">John J. Brennan</name><affiliation wicri:level="2"><nlm:affiliation>AbbVie, North Chicago, IL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>AbbVie, North Chicago, IL</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Houser, Mark" sort="Houser, Mark" uniqKey="Houser M" first="Mark" last="Houser">Mark Houser</name><affiliation wicri:level="2"><nlm:affiliation>AbbVie, North Chicago, IL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>AbbVie, North Chicago, IL</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Correa Rotter, Ricardo" sort="Correa Rotter, Ricardo" uniqKey="Correa Rotter R" first="Ricardo" last="Correa-Rotter">Ricardo Correa-Rotter</name><affiliation wicri:level="1"><nlm:affiliation>National Medical Science and Nutrition Institute Salvador Zubiran, Mexico City, Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>National Medical Science and Nutrition Institute Salvador Zubiran, Mexico City</wicri:regionArea><wicri:noRegion>Mexico City</wicri:noRegion></affiliation></author><author><name sortKey="Kohan, Donald" sort="Kohan, Donald" uniqKey="Kohan D" first="Donald" last="Kohan">Donald Kohan</name><affiliation wicri:level="2"><nlm:affiliation>University of Utah Health Sciences Center, Salt Lake City, UT, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Utah Health Sciences Center, Salt Lake City, UT</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Makino, Hirofumi" sort="Makino, Hirofumi" uniqKey="Makino H" first="Hirofumi" last="Makino">Hirofumi Makino</name><affiliation wicri:level="1"><nlm:affiliation>Okayama University Graduate School of Medicine, Okayama, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Okayama University Graduate School of Medicine, Okayama</wicri:regionArea><wicri:noRegion>Okayama</wicri:noRegion></affiliation></author><author><name sortKey="Perkovic, Vlado" sort="Perkovic, Vlado" uniqKey="Perkovic V" first="Vlado" last="Perkovic">Vlado Perkovic</name><affiliation wicri:level="4"><nlm:affiliation>The University of Sydney, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The University of Sydney, Sydney, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Remuzzi, Giuseppe" sort="Remuzzi, Giuseppe" uniqKey="Remuzzi G" first="Giuseppe" last="Remuzzi">Giuseppe Remuzzi</name><affiliation wicri:level="1"><nlm:affiliation>Azienda Ospedaliera Papa Giovanni XXIII and IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Azienda Ospedaliera Papa Giovanni XXIII and IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Bergamo</wicri:regionArea><wicri:noRegion>Bergamo</wicri:noRegion></affiliation></author><author><name sortKey="Tobe, Sheldon W" sort="Tobe, Sheldon W" uniqKey="Tobe S" first="Sheldon W" last="Tobe">Sheldon W. Tobe</name><affiliation wicri:level="1"><nlm:affiliation>Sunnybrook Health Sciences Center, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Sunnybrook Health Sciences Center, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Toto, Robert" sort="Toto, Robert" uniqKey="Toto R" first="Robert" last="Toto">Robert Toto</name><affiliation wicri:level="2"><nlm:affiliation>University of Texas Southwestern Medical Center, Dallas, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Texas Southwestern Medical Center, Dallas, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Busch, Robert" sort="Busch, Robert" uniqKey="Busch R" first="Robert" last="Busch">Robert Busch</name><affiliation wicri:level="2"><nlm:affiliation>The Endocrine Group, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Endocrine Group, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Pergola, Pablo" sort="Pergola, Pablo" uniqKey="Pergola P" first="Pablo" last="Pergola">Pablo Pergola</name><affiliation wicri:level="2"><nlm:affiliation>Renal Associates, P.A., San Antonio, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Renal Associates, P.A., San Antonio, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Parving, Hans Henrik" sort="Parving, Hans Henrik" uniqKey="Parving H" first="Hans-Henrik" last="Parving">Hans-Henrik Parving</name><affiliation wicri:level="3"><nlm:affiliation>University Hospital of Copenhagen, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>University Hospital of Copenhagen, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="De Zeeuw, Dick" sort="De Zeeuw, Dick" uniqKey="De Zeeuw D" first="Dick" last="De Zeeuw">Dick De Zeeuw</name><affiliation wicri:level="4"><nlm:affiliation>Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Centre Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region><settlement type="city">Groningue (ville)</settlement></placeName><orgName type="university">Université de Groningue</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28831752</idno><idno type="pmid">28831752</idno><idno type="doi">10.1007/s40268-017-0201-0</idno><idno type="wicri:Area/PubMed/Corpus">000522</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000522</idno><idno type="wicri:Area/PubMed/Curation">000520</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000520</idno><idno type="wicri:Area/PubMed/Checkpoint">000520</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000520</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Longitudinal Assessment of the Effect of Atrasentan on Thoracic Bioimpedance in Diabetic Nephropathy: A Randomized, Double-Blind, Placebo-Controlled Trial.</title><author><name sortKey="Webb, David J" sort="Webb, David J" uniqKey="Webb D" first="David J" last="Webb">David J. Webb</name><affiliation wicri:level="4"><nlm:affiliation>Edinburgh Hypertension Excellence Centre, Clinical Pharmacology Unit, University of Edinburgh, E3.22, QMRI, 47 Little France Crescent, Edinburgh, EH16 4TJ, Scotland, UK. D.J.Webb@ed.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Edinburgh Hypertension Excellence Centre, Clinical Pharmacology Unit, University of Edinburgh, E3.22, QMRI, 47 Little France Crescent, Edinburgh, EH16 4TJ, Scotland</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Coll, Blai" sort="Coll, Blai" uniqKey="Coll B" first="Blai" last="Coll">Blai Coll</name><affiliation wicri:level="2"><nlm:affiliation>AbbVie, North Chicago, IL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>AbbVie, North Chicago, IL</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Heerspink, Hiddo J L" sort="Heerspink, Hiddo J L" uniqKey="Heerspink H" first="Hiddo J L" last="Heerspink">Hiddo J L. Heerspink</name><affiliation wicri:level="4"><nlm:affiliation>Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Centre Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region><settlement type="city">Groningue (ville)</settlement></placeName><orgName type="university">Université de Groningue</orgName></affiliation></author><author><name sortKey="Andress, Dennis" sort="Andress, Dennis" uniqKey="Andress D" first="Dennis" last="Andress">Dennis Andress</name><affiliation wicri:level="2"><nlm:affiliation>AbbVie, North Chicago, IL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>AbbVie, North Chicago, IL</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Pritchett, Yili" sort="Pritchett, Yili" uniqKey="Pritchett Y" first="Yili" last="Pritchett">Yili Pritchett</name><affiliation wicri:level="2"><nlm:affiliation>MedImmune, Gaithersburg, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>MedImmune, Gaithersburg, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Brennan, John J" sort="Brennan, John J" uniqKey="Brennan J" first="John J" last="Brennan">John J. Brennan</name><affiliation wicri:level="2"><nlm:affiliation>AbbVie, North Chicago, IL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>AbbVie, North Chicago, IL</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Houser, Mark" sort="Houser, Mark" uniqKey="Houser M" first="Mark" last="Houser">Mark Houser</name><affiliation wicri:level="2"><nlm:affiliation>AbbVie, North Chicago, IL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>AbbVie, North Chicago, IL</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Correa Rotter, Ricardo" sort="Correa Rotter, Ricardo" uniqKey="Correa Rotter R" first="Ricardo" last="Correa-Rotter">Ricardo Correa-Rotter</name><affiliation wicri:level="1"><nlm:affiliation>National Medical Science and Nutrition Institute Salvador Zubiran, Mexico City, Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>National Medical Science and Nutrition Institute Salvador Zubiran, Mexico City</wicri:regionArea><wicri:noRegion>Mexico City</wicri:noRegion></affiliation></author><author><name sortKey="Kohan, Donald" sort="Kohan, Donald" uniqKey="Kohan D" first="Donald" last="Kohan">Donald Kohan</name><affiliation wicri:level="2"><nlm:affiliation>University of Utah Health Sciences Center, Salt Lake City, UT, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Utah Health Sciences Center, Salt Lake City, UT</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Makino, Hirofumi" sort="Makino, Hirofumi" uniqKey="Makino H" first="Hirofumi" last="Makino">Hirofumi Makino</name><affiliation wicri:level="1"><nlm:affiliation>Okayama University Graduate School of Medicine, Okayama, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Okayama University Graduate School of Medicine, Okayama</wicri:regionArea><wicri:noRegion>Okayama</wicri:noRegion></affiliation></author><author><name sortKey="Perkovic, Vlado" sort="Perkovic, Vlado" uniqKey="Perkovic V" first="Vlado" last="Perkovic">Vlado Perkovic</name><affiliation wicri:level="4"><nlm:affiliation>The University of Sydney, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The University of Sydney, Sydney, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Remuzzi, Giuseppe" sort="Remuzzi, Giuseppe" uniqKey="Remuzzi G" first="Giuseppe" last="Remuzzi">Giuseppe Remuzzi</name><affiliation wicri:level="1"><nlm:affiliation>Azienda Ospedaliera Papa Giovanni XXIII and IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Azienda Ospedaliera Papa Giovanni XXIII and IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Bergamo</wicri:regionArea><wicri:noRegion>Bergamo</wicri:noRegion></affiliation></author><author><name sortKey="Tobe, Sheldon W" sort="Tobe, Sheldon W" uniqKey="Tobe S" first="Sheldon W" last="Tobe">Sheldon W. Tobe</name><affiliation wicri:level="1"><nlm:affiliation>Sunnybrook Health Sciences Center, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Sunnybrook Health Sciences Center, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Toto, Robert" sort="Toto, Robert" uniqKey="Toto R" first="Robert" last="Toto">Robert Toto</name><affiliation wicri:level="2"><nlm:affiliation>University of Texas Southwestern Medical Center, Dallas, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Texas Southwestern Medical Center, Dallas, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Busch, Robert" sort="Busch, Robert" uniqKey="Busch R" first="Robert" last="Busch">Robert Busch</name><affiliation wicri:level="2"><nlm:affiliation>The Endocrine Group, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Endocrine Group, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Pergola, Pablo" sort="Pergola, Pablo" uniqKey="Pergola P" first="Pablo" last="Pergola">Pablo Pergola</name><affiliation wicri:level="2"><nlm:affiliation>Renal Associates, P.A., San Antonio, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Renal Associates, P.A., San Antonio, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Parving, Hans Henrik" sort="Parving, Hans Henrik" uniqKey="Parving H" first="Hans-Henrik" last="Parving">Hans-Henrik Parving</name><affiliation wicri:level="3"><nlm:affiliation>University Hospital of Copenhagen, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>University Hospital of Copenhagen, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="De Zeeuw, Dick" sort="De Zeeuw, Dick" uniqKey="De Zeeuw D" first="Dick" last="De Zeeuw">Dick De Zeeuw</name><affiliation wicri:level="4"><nlm:affiliation>Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Centre Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region><settlement type="city">Groningue (ville)</settlement></placeName><orgName type="university">Université de Groningue</orgName></affiliation></author></analytic><series><title level="j">Drugs in R&D</title><idno type="eISSN">1179-6901</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Fluid retention is a common adverse event in patients who receive endothelin (ET) receptor antagonist therapy, including the highly selective ETA receptor antagonist, atrasentan.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28831752</PMID><DateCreated><Year>2017</Year><Month>08</Month><Day>23</Day></DateCreated><DateRevised><Year>2017</Year><Month>11</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1179-6901</ISSN><JournalIssue CitedMedium="Internet"><Volume>17</Volume><Issue>3</Issue><PubDate><Year>2017</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Drugs in R&D</Title><ISOAbbreviation>Drugs R D</ISOAbbreviation></Journal><ArticleTitle>Longitudinal Assessment of the Effect of Atrasentan on Thoracic Bioimpedance in Diabetic Nephropathy: A Randomized, Double-Blind, Placebo-Controlled Trial.</ArticleTitle><Pagination><MedlinePgn>441-448</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s40268-017-0201-0</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Fluid retention is a common adverse event in patients who receive endothelin (ET) receptor antagonist therapy, including the highly selective ETA receptor antagonist, atrasentan.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">We performed longitudinal assessments of thoracic bioimpedance in patients with type 2 diabetes mellitus and nephropathy to determine whether a decrease in bioimpedance accurately reflected fluid retention during treatment with atrasentan.</AbstractText><AbstractText Label="STUDY DESIGN" NlmCategory="METHODS">We conducted a randomized, double-blind, placebo-controlled study in 48 patients with type 2 diabetes mellitus and nephropathy who were receiving stable doses of renin angiotensin system inhibitors and diuretics.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Patients were randomized 1:1:1 to placebo, atrasentan 0.5 mg, or atrasentan 1.25 mg once daily for 8 weeks. Thoracic bioimpedance, vital signs, clinical exams, and serologies were taken at weeks 1, 2, 4, 6, and 8, with the exception of serum hemoglobin, which was not taken at week 1, and serum brain natriuretic peptide, which was only taken at baseline, week 4, and week 8.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Alterations in bioimpedance were more often present in those who received atrasentan than in those who received placebo, though overall differences were not statistically significant. Transient declines in thoracic bioimpedance during the first 2 weeks of atrasentan exposure occurred before or during peak increases in body weight and hemodilution (decreased serum hemoglobin).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">We conclude that thoracic bioimpedance did not reflect changes in weight gain or edema with atrasentan treatment in this study. However, the sample size was small, and it may be of interest to explore the use of thoracic bioimpedance in a larger population to understand its potential clinical use in monitoring fluid retention in patients with chronic kidney disease who receive ET receptor antagonists.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Webb</LastName><ForeName>David J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>Edinburgh Hypertension Excellence Centre, Clinical Pharmacology Unit, University of Edinburgh, E3.22, QMRI, 47 Little France Crescent, Edinburgh, EH16 4TJ, Scotland, UK. D.J.Webb@ed.ac.uk.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Coll</LastName><ForeName>Blai</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>AbbVie, North Chicago, IL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Heerspink</LastName><ForeName>Hiddo J L</ForeName><Initials>HJL</Initials><AffiliationInfo><Affiliation>Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Andress</LastName><ForeName>Dennis</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>AbbVie, North Chicago, IL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pritchett</LastName><ForeName>Yili</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>MedImmune, Gaithersburg, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brennan</LastName><ForeName>John J</ForeName><Initials>JJ</Initials><AffiliationInfo><Affiliation>AbbVie, North Chicago, IL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Houser</LastName><ForeName>Mark</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>AbbVie, North Chicago, IL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Correa-Rotter</LastName><ForeName>Ricardo</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>National Medical Science and Nutrition Institute Salvador Zubiran, Mexico City, Mexico.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kohan</LastName><ForeName>Donald</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>University of Utah Health Sciences Center, Salt Lake City, UT, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Makino</LastName><ForeName>Hirofumi</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Okayama University Graduate School of Medicine, Okayama, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Perkovic</LastName><ForeName>Vlado</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>The University of Sydney, Sydney, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Remuzzi</LastName><ForeName>Giuseppe</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Azienda Ospedaliera Papa Giovanni XXIII and IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tobe</LastName><ForeName>Sheldon W</ForeName><Initials>SW</Initials><AffiliationInfo><Affiliation>Sunnybrook Health Sciences Center, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Toto</LastName><ForeName>Robert</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>University of Texas Southwestern Medical Center, Dallas, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Busch</LastName><ForeName>Robert</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>The Endocrine Group, New York, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pergola</LastName><ForeName>Pablo</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Renal Associates, P.A., San Antonio, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Parving</LastName><ForeName>Hans-Henrik</ForeName><Initials>HH</Initials><AffiliationInfo><Affiliation>University Hospital of Copenhagen, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Zeeuw</LastName><ForeName>Dick</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>New Zealand</Country><MedlineTA>Drugs R D</MedlineTA><NlmUniqueID>100883647</NlmUniqueID><ISSNLinking>1174-5886</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>J Am Coll Cardiol. 2006 Jun 6;47(11):2245-52</RefSource><PMID Version="1">16750691</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Am Soc Nephrol. 2011 Apr;22(4):763-72</RefSource><PMID Version="1">21372210</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Am Soc 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Version="1">19748665</PMID></CommentsCorrections></CommentsCorrectionsList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>8</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>8</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>8</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28831752</ArticleId><ArticleId IdType="doi">10.1007/s40268-017-0201-0</ArticleId><ArticleId IdType="pii">10.1007/s40268-017-0201-0</ArticleId><ArticleId IdType="pmc">PMC5629141</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>Canada</li><li>Danemark</li><li>Italie</li><li>Japon</li><li>Mexique</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Groningue (province)</li><li>Hovedstaden</li><li>Illinois</li><li>Maryland</li><li>Nouvelle-Galles du Sud</li><li>Texas</li><li>Utah</li><li>Écosse</li><li>État de New York</li></region><settlement><li>Copenhague</li><li>Groningue</li><li>Groningue (ville)</li><li>Sydney</li><li>Édimbourg</li></settlement><orgName><li>Université d'Édimbourg</li><li>Université de Groningue</li><li>Université de Sydney</li></orgName></list><tree><country name="Royaume-Uni"><region name="Écosse"><name sortKey="Webb, David J" sort="Webb, David J" uniqKey="Webb D" first="David J" last="Webb">David J. Webb</name></region></country><country name="États-Unis"><region name="Illinois"><name sortKey="Coll, Blai" sort="Coll, Blai" uniqKey="Coll B" first="Blai" last="Coll">Blai Coll</name></region><name sortKey="Andress, Dennis" sort="Andress, Dennis" uniqKey="Andress D" first="Dennis" last="Andress">Dennis Andress</name><name sortKey="Brennan, John J" sort="Brennan, John J" uniqKey="Brennan J" first="John J" last="Brennan">John J. Brennan</name><name sortKey="Busch, Robert" sort="Busch, Robert" uniqKey="Busch R" first="Robert" last="Busch">Robert Busch</name><name sortKey="Houser, Mark" sort="Houser, Mark" uniqKey="Houser M" first="Mark" last="Houser">Mark Houser</name><name sortKey="Kohan, Donald" sort="Kohan, Donald" uniqKey="Kohan D" first="Donald" last="Kohan">Donald Kohan</name><name sortKey="Pergola, Pablo" sort="Pergola, Pablo" uniqKey="Pergola P" first="Pablo" last="Pergola">Pablo Pergola</name><name sortKey="Pritchett, Yili" sort="Pritchett, Yili" uniqKey="Pritchett Y" first="Yili" last="Pritchett">Yili Pritchett</name><name sortKey="Toto, Robert" sort="Toto, Robert" uniqKey="Toto R" first="Robert" last="Toto">Robert Toto</name></country><country name="Pays-Bas"><region name="Groningue (province)"><name sortKey="Heerspink, Hiddo J L" sort="Heerspink, Hiddo J L" uniqKey="Heerspink H" first="Hiddo J L" last="Heerspink">Hiddo J L. Heerspink</name></region><name sortKey="De Zeeuw, Dick" sort="De Zeeuw, Dick" uniqKey="De Zeeuw D" first="Dick" last="De Zeeuw">Dick De Zeeuw</name></country><country name="Mexique"><noRegion><name sortKey="Correa Rotter, Ricardo" sort="Correa Rotter, Ricardo" uniqKey="Correa Rotter R" first="Ricardo" last="Correa-Rotter">Ricardo Correa-Rotter</name></noRegion></country><country name="Japon"><noRegion><name sortKey="Makino, Hirofumi" sort="Makino, Hirofumi" uniqKey="Makino H" first="Hirofumi" last="Makino">Hirofumi Makino</name></noRegion></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Perkovic, Vlado" sort="Perkovic, Vlado" uniqKey="Perkovic V" first="Vlado" last="Perkovic">Vlado Perkovic</name></region></country><country name="Italie"><noRegion><name sortKey="Remuzzi, Giuseppe" sort="Remuzzi, Giuseppe" uniqKey="Remuzzi G" first="Giuseppe" last="Remuzzi">Giuseppe Remuzzi</name></noRegion></country><country name="Canada"><noRegion><name sortKey="Tobe, Sheldon W" sort="Tobe, Sheldon W" uniqKey="Tobe S" first="Sheldon W" last="Tobe">Sheldon W. Tobe</name></noRegion></country><country name="Danemark"><region name="Hovedstaden"><name sortKey="Parving, Hans Henrik" sort="Parving, Hans Henrik" uniqKey="Parving H" first="Hans-Henrik" last="Parving">Hans-Henrik Parving</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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