Navigation through the Plasma Membrane Molecular Landscape Shapes Random Organelle Movement.
Identifieur interne : 000748 ( PubMed/Checkpoint ); précédent : 000747; suivant : 000749Navigation through the Plasma Membrane Molecular Landscape Shapes Random Organelle Movement.
Auteurs : Alison R. Dun ; Gabriel J. Lord [Royaume-Uni] ; Rhodri S. Wilson ; Deirdre M. Kavanagh ; Katarzyna I. Cialowicz ; Shuzo Sugita [Canada] ; Seungmee Park [Canada] ; Lei Yang ; Annya M. Smyth [Royaume-Uni] ; Andreas Papadopulos [Australie] ; Colin Rickman ; Rory R. Duncan [Royaume-Uni]Source :
- Current biology : CB [ 1879-0445 ] ; 2017.
Abstract
Eukaryotic plasma membrane organization theory has long been controversial, in part due to a dearth of suitably high-resolution techniques to probe molecular architecture in situ and integrate information from diverse data streams [1]. Notably, clustered patterning of membrane proteins is a commonly conserved feature across diverse protein families (reviewed in [2]), including the SNAREs [3], SM proteins [4, 5], ion channels [6, 7], and receptors (e.g., [8]). Much effort has gone into analyzing the behavior of secretory organelles [9-13], and understanding the relationship between the membrane and proximal organelles [4, 5, 12, 14] is an essential goal for cell biology as broad concepts or rules may be established. Here we explore the generally accepted model that vesicles at the plasmalemma are guided by cytoskeletal tracks to specific sites on the membrane that have clustered molecular machinery for secretion [15], organized in part by the local lipid composition [16]. To increase our understanding of these fundamental processes, we integrated nanoscopy and spectroscopy of the secretory machinery with organelle tracking data in a mathematical model, iterating with knockdown cell models. We find that repeated routes followed by successive vesicles, the re-use of similar fusion sites, and the apparently distinct vesicle "pools" are all fashioned by the Brownian behavior of organelles overlaid on navigation between non-reactive secretory protein molecular depots patterned at the plasma membrane.
DOI: 10.1016/j.cub.2016.12.002
PubMed: 28089515
Affiliations:
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Lord</name><affiliation wicri:level="1"><nlm:affiliation>Department of Mathematics, Maxwell Institute, MACS, Heriot-Watt University, Edinburgh EH14 4AS, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Mathematics, Maxwell Institute, MACS, Heriot-Watt University, Edinburgh EH14 4AS</wicri:regionArea><wicri:noRegion>Edinburgh EH14 4AS</wicri:noRegion></affiliation></author><author><name sortKey="Wilson, Rhodri S" sort="Wilson, Rhodri S" uniqKey="Wilson R" first="Rhodri S" last="Wilson">Rhodri S. Wilson</name><affiliation><nlm:affiliation>Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University, Edinburgh EH14 4AS, UK; Edinburgh Super-Resolution Imaging Consortium.</nlm:affiliation><wicri:noCountry code="subField">UK; Edinburgh Super-Resolution Imaging Consortium</wicri:noCountry></affiliation></author><author><name sortKey="Kavanagh, Deirdre M" sort="Kavanagh, Deirdre M" uniqKey="Kavanagh D" first="Deirdre M" last="Kavanagh">Deirdre M. Kavanagh</name><affiliation><nlm:affiliation>Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University, Edinburgh EH14 4AS, UK; Edinburgh Super-Resolution Imaging Consortium.</nlm:affiliation><wicri:noCountry code="subField">UK; Edinburgh Super-Resolution Imaging Consortium</wicri:noCountry></affiliation></author><author><name sortKey="Cialowicz, Katarzyna I" sort="Cialowicz, Katarzyna I" uniqKey="Cialowicz K" first="Katarzyna I" last="Cialowicz">Katarzyna I. Cialowicz</name><affiliation><nlm:affiliation>Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University, Edinburgh EH14 4AS, UK; Edinburgh Super-Resolution Imaging Consortium.</nlm:affiliation><wicri:noCountry code="subField">UK; Edinburgh Super-Resolution Imaging Consortium</wicri:noCountry></affiliation></author><author><name sortKey="Sugita, Shuzo" sort="Sugita, Shuzo" uniqKey="Sugita S" first="Shuzo" last="Sugita">Shuzo Sugita</name><affiliation wicri:level="1"><nlm:affiliation>Toronto Western Research Institute, Room 11-432, McLaughlin Wing, 399 Bathurst St., Toronto, ON M5T 2S8, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto Western Research Institute, Room 11-432, McLaughlin Wing, 399 Bathurst St., Toronto, ON M5T 2S8</wicri:regionArea><wicri:noRegion>ON M5T 2S8</wicri:noRegion></affiliation></author><author><name sortKey="Park, Seungmee" sort="Park, Seungmee" uniqKey="Park S" first="Seungmee" last="Park">Seungmee Park</name><affiliation wicri:level="1"><nlm:affiliation>Toronto Western Research Institute, Room 11-432, McLaughlin Wing, 399 Bathurst St., Toronto, ON M5T 2S8, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto Western Research Institute, Room 11-432, McLaughlin Wing, 399 Bathurst St., Toronto, ON M5T 2S8</wicri:regionArea><wicri:noRegion>ON M5T 2S8</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Lei" sort="Yang, Lei" uniqKey="Yang L" first="Lei" last="Yang">Lei Yang</name><affiliation><nlm:affiliation>Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University, Edinburgh EH14 4AS, UK; Edinburgh Super-Resolution Imaging Consortium.</nlm:affiliation><wicri:noCountry code="subField">UK; Edinburgh Super-Resolution Imaging Consortium</wicri:noCountry></affiliation></author><author><name sortKey="Smyth, Annya M" sort="Smyth, Annya M" uniqKey="Smyth A" first="Annya M" last="Smyth">Annya M. Smyth</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Inflammation Research, University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Inflammation Research, University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Papadopulos, Andreas" sort="Papadopulos, Andreas" uniqKey="Papadopulos A" first="Andreas" last="Papadopulos">Andreas Papadopulos</name><affiliation wicri:level="1"><nlm:affiliation>The Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072</wicri:regionArea><wicri:noRegion>QLD 4072</wicri:noRegion></affiliation></author><author><name sortKey="Rickman, Colin" sort="Rickman, Colin" uniqKey="Rickman C" first="Colin" last="Rickman">Colin Rickman</name><affiliation><nlm:affiliation>Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University, Edinburgh EH14 4AS, UK; Edinburgh Super-Resolution Imaging Consortium.</nlm:affiliation><wicri:noCountry code="subField">UK; Edinburgh Super-Resolution Imaging Consortium</wicri:noCountry></affiliation></author><author><name sortKey="Duncan, Rory R" sort="Duncan, Rory R" uniqKey="Duncan R" first="Rory R" last="Duncan">Rory R. Duncan</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University, Edinburgh EH14 4AS, UK; Edinburgh Super-Resolution Imaging Consortium. Electronic address: r.r.duncan@hw.ac.uk.</nlm:affiliation><country wicri:rule="url">Royaume-Uni</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28089515</idno><idno type="pmid">28089515</idno><idno type="doi">10.1016/j.cub.2016.12.002</idno><idno type="wicri:Area/PubMed/Corpus">001150</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001150</idno><idno type="wicri:Area/PubMed/Curation">001147</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001147</idno><idno type="wicri:Area/PubMed/Checkpoint">001147</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001147</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Navigation through the Plasma Membrane Molecular Landscape Shapes Random Organelle Movement.</title><author><name sortKey="Dun, Alison R" sort="Dun, Alison R" uniqKey="Dun A" first="Alison R" last="Dun">Alison R. Dun</name><affiliation><nlm:affiliation>Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University, Edinburgh EH14 4AS, UK; Edinburgh Super-Resolution Imaging Consortium.</nlm:affiliation><wicri:noCountry code="subField">UK; Edinburgh Super-Resolution Imaging Consortium</wicri:noCountry></affiliation></author><author><name sortKey="Lord, Gabriel J" sort="Lord, Gabriel J" uniqKey="Lord G" first="Gabriel J" last="Lord">Gabriel J. Lord</name><affiliation wicri:level="1"><nlm:affiliation>Department of Mathematics, Maxwell Institute, MACS, Heriot-Watt University, Edinburgh EH14 4AS, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Mathematics, Maxwell Institute, MACS, Heriot-Watt University, Edinburgh EH14 4AS</wicri:regionArea><wicri:noRegion>Edinburgh EH14 4AS</wicri:noRegion></affiliation></author><author><name sortKey="Wilson, Rhodri S" sort="Wilson, Rhodri S" uniqKey="Wilson R" first="Rhodri S" last="Wilson">Rhodri S. Wilson</name><affiliation><nlm:affiliation>Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University, Edinburgh EH14 4AS, UK; Edinburgh Super-Resolution Imaging Consortium.</nlm:affiliation><wicri:noCountry code="subField">UK; Edinburgh Super-Resolution Imaging Consortium</wicri:noCountry></affiliation></author><author><name sortKey="Kavanagh, Deirdre M" sort="Kavanagh, Deirdre M" uniqKey="Kavanagh D" first="Deirdre M" last="Kavanagh">Deirdre M. Kavanagh</name><affiliation><nlm:affiliation>Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University, Edinburgh EH14 4AS, UK; Edinburgh Super-Resolution Imaging Consortium.</nlm:affiliation><wicri:noCountry code="subField">UK; Edinburgh Super-Resolution Imaging Consortium</wicri:noCountry></affiliation></author><author><name sortKey="Cialowicz, Katarzyna I" sort="Cialowicz, Katarzyna I" uniqKey="Cialowicz K" first="Katarzyna I" last="Cialowicz">Katarzyna I. Cialowicz</name><affiliation><nlm:affiliation>Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University, Edinburgh EH14 4AS, UK; Edinburgh Super-Resolution Imaging Consortium.</nlm:affiliation><wicri:noCountry code="subField">UK; Edinburgh Super-Resolution Imaging Consortium</wicri:noCountry></affiliation></author><author><name sortKey="Sugita, Shuzo" sort="Sugita, Shuzo" uniqKey="Sugita S" first="Shuzo" last="Sugita">Shuzo Sugita</name><affiliation wicri:level="1"><nlm:affiliation>Toronto Western Research Institute, Room 11-432, McLaughlin Wing, 399 Bathurst St., Toronto, ON M5T 2S8, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto Western Research Institute, Room 11-432, McLaughlin Wing, 399 Bathurst St., Toronto, ON M5T 2S8</wicri:regionArea><wicri:noRegion>ON M5T 2S8</wicri:noRegion></affiliation></author><author><name sortKey="Park, Seungmee" sort="Park, Seungmee" uniqKey="Park S" first="Seungmee" last="Park">Seungmee Park</name><affiliation wicri:level="1"><nlm:affiliation>Toronto Western Research Institute, Room 11-432, McLaughlin Wing, 399 Bathurst St., Toronto, ON M5T 2S8, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto Western Research Institute, Room 11-432, McLaughlin Wing, 399 Bathurst St., Toronto, ON M5T 2S8</wicri:regionArea><wicri:noRegion>ON M5T 2S8</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Lei" sort="Yang, Lei" uniqKey="Yang L" first="Lei" last="Yang">Lei Yang</name><affiliation><nlm:affiliation>Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University, Edinburgh EH14 4AS, UK; Edinburgh Super-Resolution Imaging Consortium.</nlm:affiliation><wicri:noCountry code="subField">UK; Edinburgh Super-Resolution Imaging Consortium</wicri:noCountry></affiliation></author><author><name sortKey="Smyth, Annya M" sort="Smyth, Annya M" uniqKey="Smyth A" first="Annya M" last="Smyth">Annya M. Smyth</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Inflammation Research, University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Inflammation Research, University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Papadopulos, Andreas" sort="Papadopulos, Andreas" uniqKey="Papadopulos A" first="Andreas" last="Papadopulos">Andreas Papadopulos</name><affiliation wicri:level="1"><nlm:affiliation>The Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072</wicri:regionArea><wicri:noRegion>QLD 4072</wicri:noRegion></affiliation></author><author><name sortKey="Rickman, Colin" sort="Rickman, Colin" uniqKey="Rickman C" first="Colin" last="Rickman">Colin Rickman</name><affiliation><nlm:affiliation>Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University, Edinburgh EH14 4AS, UK; Edinburgh Super-Resolution Imaging Consortium.</nlm:affiliation><wicri:noCountry code="subField">UK; Edinburgh Super-Resolution Imaging Consortium</wicri:noCountry></affiliation></author><author><name sortKey="Duncan, Rory R" sort="Duncan, Rory R" uniqKey="Duncan R" first="Rory R" last="Duncan">Rory R. Duncan</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University, Edinburgh EH14 4AS, UK; Edinburgh Super-Resolution Imaging Consortium. Electronic address: r.r.duncan@hw.ac.uk.</nlm:affiliation><country wicri:rule="url">Royaume-Uni</country></affiliation></author></analytic><series><title level="j">Current biology : CB</title><idno type="eISSN">1879-0445</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Eukaryotic plasma membrane organization theory has long been controversial, in part due to a dearth of suitably high-resolution techniques to probe molecular architecture in situ and integrate information from diverse data streams [1]. Notably, clustered patterning of membrane proteins is a commonly conserved feature across diverse protein families (reviewed in [2]), including the SNAREs [3], SM proteins [4, 5], ion channels [6, 7], and receptors (e.g., [8]). Much effort has gone into analyzing the behavior of secretory organelles [9-13], and understanding the relationship between the membrane and proximal organelles [4, 5, 12, 14] is an essential goal for cell biology as broad concepts or rules may be established. Here we explore the generally accepted model that vesicles at the plasmalemma are guided by cytoskeletal tracks to specific sites on the membrane that have clustered molecular machinery for secretion [15], organized in part by the local lipid composition [16]. To increase our understanding of these fundamental processes, we integrated nanoscopy and spectroscopy of the secretory machinery with organelle tracking data in a mathematical model, iterating with knockdown cell models. We find that repeated routes followed by successive vesicles, the re-use of similar fusion sites, and the apparently distinct vesicle "pools" are all fashioned by the Brownian behavior of organelles overlaid on navigation between non-reactive secretory protein molecular depots patterned at the plasma membrane.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28089515</PMID><DateCreated><Year>2017</Year><Month>01</Month><Day>16</Day></DateCreated><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-0445</ISSN><JournalIssue CitedMedium="Internet"><Volume>27</Volume><Issue>3</Issue><PubDate><Year>2017</Year><Month>Feb</Month><Day>06</Day></PubDate></JournalIssue><Title>Current biology : CB</Title><ISOAbbreviation>Curr. Biol.</ISOAbbreviation></Journal><ArticleTitle>Navigation through the Plasma Membrane Molecular Landscape Shapes Random Organelle Movement.</ArticleTitle><Pagination><MedlinePgn>408-414</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0960-9822(16)31448-8</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.cub.2016.12.002</ELocationID><Abstract><AbstractText>Eukaryotic plasma membrane organization theory has long been controversial, in part due to a dearth of suitably high-resolution techniques to probe molecular architecture in situ and integrate information from diverse data streams [1]. Notably, clustered patterning of membrane proteins is a commonly conserved feature across diverse protein families (reviewed in [2]), including the SNAREs [3], SM proteins [4, 5], ion channels [6, 7], and receptors (e.g., [8]). Much effort has gone into analyzing the behavior of secretory organelles [9-13], and understanding the relationship between the membrane and proximal organelles [4, 5, 12, 14] is an essential goal for cell biology as broad concepts or rules may be established. Here we explore the generally accepted model that vesicles at the plasmalemma are guided by cytoskeletal tracks to specific sites on the membrane that have clustered molecular machinery for secretion [15], organized in part by the local lipid composition [16]. To increase our understanding of these fundamental processes, we integrated nanoscopy and spectroscopy of the secretory machinery with organelle tracking data in a mathematical model, iterating with knockdown cell models. We find that repeated routes followed by successive vesicles, the re-use of similar fusion sites, and the apparently distinct vesicle "pools" are all fashioned by the Brownian behavior of organelles overlaid on navigation between non-reactive secretory protein molecular depots patterned at the plasma membrane.</AbstractText><CopyrightInformation>Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dun</LastName><ForeName>Alison R</ForeName><Initials>AR</Initials><AffiliationInfo><Affiliation>Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University, Edinburgh EH14 4AS, UK; Edinburgh Super-Resolution Imaging Consortium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lord</LastName><ForeName>Gabriel J</ForeName><Initials>GJ</Initials><AffiliationInfo><Affiliation>Department of Mathematics, Maxwell Institute, MACS, Heriot-Watt University, Edinburgh EH14 4AS, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wilson</LastName><ForeName>Rhodri S</ForeName><Initials>RS</Initials><AffiliationInfo><Affiliation>Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University, Edinburgh EH14 4AS, UK; Edinburgh Super-Resolution Imaging Consortium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kavanagh</LastName><ForeName>Deirdre M</ForeName><Initials>DM</Initials><AffiliationInfo><Affiliation>Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University, Edinburgh EH14 4AS, UK; Edinburgh Super-Resolution Imaging Consortium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cialowicz</LastName><ForeName>Katarzyna I</ForeName><Initials>KI</Initials><AffiliationInfo><Affiliation>Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University, Edinburgh EH14 4AS, UK; Edinburgh Super-Resolution Imaging Consortium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sugita</LastName><ForeName>Shuzo</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Toronto Western Research Institute, Room 11-432, McLaughlin Wing, 399 Bathurst St., Toronto, ON M5T 2S8, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Park</LastName><ForeName>Seungmee</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Toronto Western Research Institute, Room 11-432, McLaughlin Wing, 399 Bathurst St., Toronto, ON M5T 2S8, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Lei</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University, Edinburgh EH14 4AS, UK; Edinburgh Super-Resolution Imaging Consortium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smyth</LastName><ForeName>Annya M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Centre for Inflammation Research, University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Papadopulos</LastName><ForeName>Andreas</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>The Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rickman</LastName><ForeName>Colin</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University, Edinburgh EH14 4AS, UK; Edinburgh Super-Resolution Imaging Consortium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Duncan</LastName><ForeName>Rory R</ForeName><Initials>RR</Initials><AffiliationInfo><Affiliation>Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University, Edinburgh EH14 4AS, UK; Edinburgh Super-Resolution Imaging Consortium. Electronic address: r.r.duncan@hw.ac.uk.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>G0901607</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MR/K01563X/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>01</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Curr Biol</MedlineTA><NlmUniqueID>9107782</NlmUniqueID><ISSNLinking>0960-9822</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Nat Methods. 2008 Feb;5(2):155-7</RefSource><PMID Version="1">18193054</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biophys 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MajorTopicYN="N">super-resolution</Keyword><Keyword MajorTopicYN="N">vesicle</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>06</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>09</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>12</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>1</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>1</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>1</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28089515</ArticleId><ArticleId IdType="pii">S0960-9822(16)31448-8</ArticleId><ArticleId IdType="doi">10.1016/j.cub.2016.12.002</ArticleId><ArticleId IdType="pmc">PMC5300901</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>Canada</li><li>Royaume-Uni</li></country><region><li>Écosse</li></region><settlement><li>Édimbourg</li></settlement><orgName><li>Université d'Édimbourg</li></orgName></list><tree><noCountry><name sortKey="Cialowicz, Katarzyna I" sort="Cialowicz, Katarzyna I" uniqKey="Cialowicz K" first="Katarzyna I" last="Cialowicz">Katarzyna I. Cialowicz</name><name sortKey="Dun, Alison R" sort="Dun, Alison R" uniqKey="Dun A" first="Alison R" last="Dun">Alison R. Dun</name><name sortKey="Kavanagh, Deirdre M" sort="Kavanagh, Deirdre M" uniqKey="Kavanagh D" first="Deirdre M" last="Kavanagh">Deirdre M. Kavanagh</name><name sortKey="Rickman, Colin" sort="Rickman, Colin" uniqKey="Rickman C" first="Colin" last="Rickman">Colin Rickman</name><name sortKey="Wilson, Rhodri S" sort="Wilson, Rhodri S" uniqKey="Wilson R" first="Rhodri S" last="Wilson">Rhodri S. Wilson</name><name sortKey="Yang, Lei" sort="Yang, Lei" uniqKey="Yang L" first="Lei" last="Yang">Lei Yang</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Lord, Gabriel J" sort="Lord, Gabriel J" uniqKey="Lord G" first="Gabriel J" last="Lord">Gabriel J. Lord</name></noRegion><name sortKey="Duncan, Rory R" sort="Duncan, Rory R" uniqKey="Duncan R" first="Rory R" last="Duncan">Rory R. Duncan</name><name sortKey="Smyth, Annya M" sort="Smyth, Annya M" uniqKey="Smyth A" first="Annya M" last="Smyth">Annya M. Smyth</name></country><country name="Canada"><noRegion><name sortKey="Sugita, Shuzo" sort="Sugita, Shuzo" uniqKey="Sugita S" first="Shuzo" last="Sugita">Shuzo Sugita</name></noRegion><name sortKey="Park, Seungmee" sort="Park, Seungmee" uniqKey="Park S" first="Seungmee" last="Park">Seungmee Park</name></country><country name="Australie"><noRegion><name sortKey="Papadopulos, Andreas" sort="Papadopulos, Andreas" uniqKey="Papadopulos A" first="Andreas" last="Papadopulos">Andreas Papadopulos</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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