Vitamin D and cognitive function: A Mendelian randomisation study.
Identifieur interne : 000036 ( PubMed/Checkpoint ); précédent : 000035; suivant : 000037Vitamin D and cognitive function: A Mendelian randomisation study.
Auteurs : Jane Maddock [Royaume-Uni] ; Ang Zhou [Australie] ; Alana Cavadino [Royaume-Uni] ; El Bieta Ku Ma [Royaume-Uni] ; Yanchun Bao [Royaume-Uni] ; Melissa C. Smart [Royaume-Uni] ; Kai-Uwe Saum [Allemagne] ; Ben Schöttker [Allemagne] ; Jorgen Engmann [Royaume-Uni] ; Marie Kj Rgaard [Norvège] ; Ville Karhunen [Finlande] ; Yiqiang Zhan [Suède] ; Terho Lehtim Ki [Finlande] ; Suvi P. Rovio [Finlande] ; Liisa Byberg [Suède] ; Jari Lahti [Finlande] ; Pedro Marques-Vidal [Suisse] ; Abhijit Sen [Norvège] ; Laura Perna [Allemagne] ; Henrik Schirmer [Norvège] ; Archana Singh-Manoux [Royaume-Uni] ; Juha Auvinen [Finlande] ; Nina Hutri-K Hönen [Finlande] ; Mika K Hönen [Finlande] ; Lena Kilander [Suède] ; Katri R Ikkönen [Finlande] ; H Kan Melhus [Suède] ; Erik Ingelsson [Suède] ; Idris Guessous [Suisse] ; Katja E. Petrovic [Autriche] ; Helena Schmidt [Autriche] ; Reinhold Schmidt [Autriche] ; Peter Vollenweider [Suisse] ; Lars Lind [Suède] ; Johan G. Eriksson [Finlande] ; Karl Michaëlsson [Suède] ; Olli T. Raitakari [Finlande] ; Sara H Gg [Suède] ; Nancy L. Pedersen [Suède] ; Karl-Heinz Herzig [Finlande] ; Marjo-Riitta J Rvelin [Finlande] ; Juha Veijola [Finlande] ; Mika Kivimaki [Royaume-Uni] ; Rolf Jorde [Norvège] ; Hermann Brenner [Allemagne] ; Meena Kumari [Royaume-Uni] ; Chris Power [Royaume-Uni] ; David J. Llewellyn [Royaume-Uni] ; Elina Hyppönen [Royaume-Uni]Source :
- Scientific reports [ 2045-2322 ] ; 2017.
Abstract
The causal nature of the association between hypovitaminosis D and poor cognitive function in mid- to later-life is uncertain. Using a Mendelian randomisation(MR) approach, we examined the causal relationship between 25(OH)D and cognitive function. Data came from 172,349 participants from 17 cohorts. DHCR7(rs12785878), CYP2R1 rs12794714) and their combined synthesis score were chosen to proxy 25(OH)D. Cognitive tests were standardised into global and memory scores. Analyses were stratified by 25(OH)D tertiles, sex and age. Random effects meta-analyses assessed associations between 25(OH)D and cognitive function. Associations of serum 25(OH)D with global and memory-related cognitive function were non-linear (lower cognitive scores for both low and high 25(OH)D, p curvature ≤ 0.006), with much of the curvature attributed to a single study. DHCR7, CYP2R1, and the synthesis score were associated with small reductions in 25(OH)D per vitamin D-decreasing allele. However, coefficients for associations with global or memory-related cognitive function were non-significant and in opposing directions for DHCR7 and CYP2R1, with no overall association observed for the synthesis score. Coefficients for the synthesis score and global and memory cognition were similar when stratified by 25(OH)D tertiles, sex and age. We found no evidence for serum 25(OH)D concentration as a causal factor for cognitive performance in mid- to later life.
DOI: 10.1038/s41598-017-13189-3
PubMed: 29038561
Affiliations:
- Allemagne, Australie, Autriche, Finlande, Norvège, Royaume-Uni, Suisse, Suède
- Angleterre, Bade-Wurtemberg, Canton de Vaud, District de Karlsruhe, East Middle Sweden, Finlande occidentale, Grand Londres, Svealand, Trøndelag, Uusimaa
- Heidelberg, Helsinki, Lausanne, Londres, Stockholm, Trondheim, Turku, Uppsala
- University College de Londres, Université d'Helsinki, Université d'Uppsala, Université de Turku
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:29038561Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Vitamin D and cognitive function: A Mendelian randomisation study.</title><author><name sortKey="Maddock, Jane" sort="Maddock, Jane" uniqKey="Maddock J" first="Jane" last="Maddock">Jane Maddock</name><affiliation wicri:level="3"><nlm:affiliation>MRC Lifelong Health and Ageing at UCL, London, United Kingdom. jane.maddock@ucl.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Lifelong Health and Ageing at UCL, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Zhou, Ang" sort="Zhou, Ang" uniqKey="Zhou A" first="Ang" last="Zhou">Ang Zhou</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Population Health Research, Sansom Institute, University of South Australia, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Population Health Research, Sansom Institute, University of South Australia, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Cavadino, Alana" sort="Cavadino, Alana" uniqKey="Cavadino A" first="Alana" last="Cavadino">Alana Cavadino</name><affiliation wicri:level="3"><nlm:affiliation>Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ku Ma, El Bieta" sort="Ku Ma, El Bieta" uniqKey="Ku Ma E" first="El Bieta" last="Ku Ma">El Bieta Ku Ma</name><affiliation wicri:level="1"><nlm:affiliation>University of Exeter Medical School, Exeter, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Exeter Medical School, Exeter</wicri:regionArea><wicri:noRegion>Exeter</wicri:noRegion></affiliation></author><author><name sortKey="Bao, Yanchun" sort="Bao, Yanchun" uniqKey="Bao Y" first="Yanchun" last="Bao">Yanchun Bao</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Social and Economic Research (ISER), University of Essex, Colchester, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute for Social and Economic Research (ISER), University of Essex, Colchester</wicri:regionArea><wicri:noRegion>Colchester</wicri:noRegion></affiliation></author><author><name sortKey="Smart, Melissa C" sort="Smart, Melissa C" uniqKey="Smart M" first="Melissa C" last="Smart">Melissa C. Smart</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Social and Economic Research (ISER), University of Essex, Colchester, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute for Social and Economic Research (ISER), University of Essex, Colchester</wicri:regionArea><wicri:noRegion>Colchester</wicri:noRegion></affiliation></author><author><name sortKey="Saum, Kai Uwe" sort="Saum, Kai Uwe" uniqKey="Saum K" first="Kai-Uwe" last="Saum">Kai-Uwe Saum</name><affiliation wicri:level="3"><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Schottker, Ben" sort="Schottker, Ben" uniqKey="Schottker B" first="Ben" last="Schöttker">Ben Schöttker</name><affiliation wicri:level="3"><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Engmann, Jorgen" sort="Engmann, Jorgen" uniqKey="Engmann J" first="Jorgen" last="Engmann">Jorgen Engmann</name><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology and Public Health, University College London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Public Health, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Kj Rgaard, Marie" sort="Kj Rgaard, Marie" uniqKey="Kj Rgaard M" first="Marie" last="Kj Rgaard">Marie Kj Rgaard</name><affiliation wicri:level="1"><nlm:affiliation>Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Division of Internal Medicine, University Hospital of North Norway, Tromsø</wicri:regionArea><wicri:noRegion>Tromsø</wicri:noRegion></affiliation></author><author><name sortKey="Karhunen, Ville" sort="Karhunen, Ville" uniqKey="Karhunen V" first="Ville" last="Karhunen">Ville Karhunen</name><affiliation wicri:level="1"><nlm:affiliation>Center for Life Course Health Research, University of Oulu, Oulu, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Center for Life Course Health Research, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Zhan, Yiqiang" sort="Zhan, Yiqiang" uniqKey="Zhan Y" first="Yiqiang" last="Zhan">Yiqiang Zhan</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Life Sciences, University of Tampere, Tampere</wicri:regionArea><wicri:noRegion>Tampere</wicri:noRegion></affiliation></author><author><name sortKey="Rovio, Suvi P" sort="Rovio, Suvi P" uniqKey="Rovio S" first="Suvi P" last="Rovio">Suvi P. Rovio</name><affiliation wicri:level="4"><nlm:affiliation>Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku</wicri:regionArea><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region><settlement type="city">Turku</settlement></placeName><orgName type="university">Université de Turku</orgName></affiliation></author><author><name sortKey="Byberg, Liisa" sort="Byberg, Liisa" uniqKey="Byberg L" first="Liisa" last="Byberg">Liisa Byberg</name><affiliation wicri:level="4"><nlm:affiliation>Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Surgical Sciences, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Psychology and Logopedics, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Marques Vidal, Pedro" sort="Marques Vidal, Pedro" uniqKey="Marques Vidal P" first="Pedro" last="Marques-Vidal">Pedro Marques-Vidal</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Sen, Abhijit" sort="Sen, Abhijit" uniqKey="Sen A" first="Abhijit" last="Sen">Abhijit Sen</name><affiliation wicri:level="3"><nlm:affiliation>Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim</wicri:regionArea><placeName><settlement type="city">Trondheim</settlement><region type="région" nuts="2">Trøndelag</region></placeName></affiliation></author><author><name sortKey="Perna, Laura" sort="Perna, Laura" uniqKey="Perna L" first="Laura" last="Perna">Laura Perna</name><affiliation wicri:level="3"><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Schirmer, Henrik" sort="Schirmer, Henrik" uniqKey="Schirmer H" first="Henrik" last="Schirmer">Henrik Schirmer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø</wicri:regionArea><wicri:noRegion>Tromsø</wicri:noRegion></affiliation></author><author><name sortKey="Singh Manoux, Archana" sort="Singh Manoux, Archana" uniqKey="Singh Manoux A" first="Archana" last="Singh-Manoux">Archana Singh-Manoux</name><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology and Public Health, University College London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Public Health, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Auvinen, Juha" sort="Auvinen, Juha" uniqKey="Auvinen J" first="Juha" last="Auvinen">Juha Auvinen</name><affiliation wicri:level="1"><nlm:affiliation>Center for Life Course Health Research, University of Oulu, Oulu, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Center for Life Course Health Research, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Hutri K Honen, Nina" sort="Hutri K Honen, Nina" uniqKey="Hutri K Honen N" first="Nina" last="Hutri-K Hönen">Nina Hutri-K Hönen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Pediatrics, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere</wicri:regionArea><wicri:noRegion>Tampere</wicri:noRegion></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere</wicri:regionArea><wicri:noRegion>Tampere</wicri:noRegion></affiliation></author><author><name sortKey="Kilander, Lena" sort="Kilander, Lena" uniqKey="Kilander L" first="Lena" last="Kilander">Lena Kilander</name><affiliation wicri:level="4"><nlm:affiliation>Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Public Health and Caring Sciences, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="R Ikkonen, Katri" sort="R Ikkonen, Katri" uniqKey="R Ikkonen K" first="Katri" last="R Ikkönen">Katri R Ikkönen</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Psychology and Logopedics, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Melhus, H Kan" sort="Melhus, H Kan" uniqKey="Melhus H" first="H Kan" last="Melhus">H Kan Melhus</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Guessous, Idris" sort="Guessous, Idris" uniqKey="Guessous I" first="Idris" last="Guessous">Idris Guessous</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Population Epidemiology, Division of Primary Care Medicine, Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University Hospitals, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Unit of Population Epidemiology, Division of Primary Care Medicine, Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University Hospitals, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Petrovic, Katja E" sort="Petrovic, Katja E" uniqKey="Petrovic K" first="Katja E" last="Petrovic">Katja E. Petrovic</name><affiliation wicri:level="1"><nlm:affiliation>Division of General Neurology, Department of Neurology, General Hospital and Medical University of Graz, Graz, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of General Neurology, Department of Neurology, General Hospital and Medical University of Graz, Graz</wicri:regionArea><wicri:noRegion>Graz</wicri:noRegion></affiliation></author><author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><affiliation wicri:level="1"><nlm:affiliation>Research Unit for Genetic Epidemiology, Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Graz, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Research Unit for Genetic Epidemiology, Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Graz</wicri:regionArea><wicri:noRegion>Graz</wicri:noRegion></affiliation></author><author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz</wicri:regionArea><wicri:noRegion>Graz</wicri:noRegion></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G" last="Eriksson">Johan G. Eriksson</name><affiliation wicri:level="1"><nlm:affiliation>Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, University of Helsinki, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, University of Helsinki, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Michaelsson, Karl" sort="Michaelsson, Karl" uniqKey="Michaelsson K" first="Karl" last="Michaëlsson">Karl Michaëlsson</name><affiliation wicri:level="4"><nlm:affiliation>Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Surgical Sciences, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Raitakari, Olli T" sort="Raitakari, Olli T" uniqKey="Raitakari O" first="Olli T" last="Raitakari">Olli T. Raitakari</name><affiliation wicri:level="4"><nlm:affiliation>Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku</wicri:regionArea><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region><settlement type="city">Turku</settlement></placeName><orgName type="university">Université de Turku</orgName></affiliation></author><author><name sortKey="H Gg, Sara" sort="H Gg, Sara" uniqKey="H Gg S" first="Sara" last="H Gg">Sara H Gg</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Pedersen, Nancy L" sort="Pedersen, Nancy L" uniqKey="Pedersen N" first="Nancy L" last="Pedersen">Nancy L. Pedersen</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Herzig, Karl Heinz" sort="Herzig, Karl Heinz" uniqKey="Herzig K" first="Karl-Heinz" last="Herzig">Karl-Heinz Herzig</name><affiliation wicri:level="1"><nlm:affiliation>Research Unit of Biomedicine, University of Oulu, Oulu, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Research Unit of Biomedicine, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="J Rvelin, Marjo Riitta" sort="J Rvelin, Marjo Riitta" uniqKey="J Rvelin M" first="Marjo-Riitta" last="J Rvelin">Marjo-Riitta J Rvelin</name><affiliation wicri:level="1"><nlm:affiliation>Center for Life Course Health Research, University of Oulu, Oulu, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Center for Life Course Health Research, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Veijola, Juha" sort="Veijola, Juha" uniqKey="Veijola J" first="Juha" last="Veijola">Juha Veijola</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Center (MRC) and Oulu University Hospital, Oulu, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Medical Research Center (MRC) and Oulu University Hospital, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Kivimaki, Mika" sort="Kivimaki, Mika" uniqKey="Kivimaki M" first="Mika" last="Kivimaki">Mika Kivimaki</name><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology and Public Health, University College London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Public Health, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Jorde, Rolf" sort="Jorde, Rolf" uniqKey="Jorde R" first="Rolf" last="Jorde">Rolf Jorde</name><affiliation wicri:level="1"><nlm:affiliation>Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Division of Internal Medicine, University Hospital of North Norway, Tromsø</wicri:regionArea><wicri:noRegion>Tromsø</wicri:noRegion></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="3"><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Kumari, Meena" sort="Kumari, Meena" uniqKey="Kumari M" first="Meena" last="Kumari">Meena Kumari</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Social and Economic Research (ISER), University of Essex, Colchester, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute for Social and Economic Research (ISER), University of Essex, Colchester</wicri:regionArea><wicri:noRegion>Colchester</wicri:noRegion></affiliation></author><author><name sortKey="Power, Chris" sort="Power, Chris" uniqKey="Power C" first="Chris" last="Power">Chris Power</name><affiliation wicri:level="3"><nlm:affiliation>Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Llewellyn, David J" sort="Llewellyn, David J" uniqKey="Llewellyn D" first="David J" last="Llewellyn">David J. Llewellyn</name><affiliation wicri:level="1"><nlm:affiliation>University of Exeter Medical School, Exeter, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Exeter Medical School, Exeter</wicri:regionArea><wicri:noRegion>Exeter</wicri:noRegion></affiliation></author><author><name sortKey="Hypponen, Elina" sort="Hypponen, Elina" uniqKey="Hypponen E" first="Elina" last="Hyppönen">Elina Hyppönen</name><affiliation wicri:level="3"><nlm:affiliation>Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, United Kingdom. elina.hypponen@unisa.edu.au.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:29038561</idno><idno type="pmid">29038561</idno><idno type="doi">10.1038/s41598-017-13189-3</idno><idno type="wicri:Area/PubMed/Corpus">000373</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000373</idno><idno type="wicri:Area/PubMed/Curation">000371</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000371</idno><idno type="wicri:Area/PubMed/Checkpoint">000371</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000371</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Vitamin D and cognitive function: A Mendelian randomisation study.</title><author><name sortKey="Maddock, Jane" sort="Maddock, Jane" uniqKey="Maddock J" first="Jane" last="Maddock">Jane Maddock</name><affiliation wicri:level="3"><nlm:affiliation>MRC Lifelong Health and Ageing at UCL, London, United Kingdom. jane.maddock@ucl.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Lifelong Health and Ageing at UCL, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Zhou, Ang" sort="Zhou, Ang" uniqKey="Zhou A" first="Ang" last="Zhou">Ang Zhou</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Population Health Research, Sansom Institute, University of South Australia, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Population Health Research, Sansom Institute, University of South Australia, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Cavadino, Alana" sort="Cavadino, Alana" uniqKey="Cavadino A" first="Alana" last="Cavadino">Alana Cavadino</name><affiliation wicri:level="3"><nlm:affiliation>Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ku Ma, El Bieta" sort="Ku Ma, El Bieta" uniqKey="Ku Ma E" first="El Bieta" last="Ku Ma">El Bieta Ku Ma</name><affiliation wicri:level="1"><nlm:affiliation>University of Exeter Medical School, Exeter, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Exeter Medical School, Exeter</wicri:regionArea><wicri:noRegion>Exeter</wicri:noRegion></affiliation></author><author><name sortKey="Bao, Yanchun" sort="Bao, Yanchun" uniqKey="Bao Y" first="Yanchun" last="Bao">Yanchun Bao</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Social and Economic Research (ISER), University of Essex, Colchester, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute for Social and Economic Research (ISER), University of Essex, Colchester</wicri:regionArea><wicri:noRegion>Colchester</wicri:noRegion></affiliation></author><author><name sortKey="Smart, Melissa C" sort="Smart, Melissa C" uniqKey="Smart M" first="Melissa C" last="Smart">Melissa C. Smart</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Social and Economic Research (ISER), University of Essex, Colchester, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute for Social and Economic Research (ISER), University of Essex, Colchester</wicri:regionArea><wicri:noRegion>Colchester</wicri:noRegion></affiliation></author><author><name sortKey="Saum, Kai Uwe" sort="Saum, Kai Uwe" uniqKey="Saum K" first="Kai-Uwe" last="Saum">Kai-Uwe Saum</name><affiliation wicri:level="3"><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Schottker, Ben" sort="Schottker, Ben" uniqKey="Schottker B" first="Ben" last="Schöttker">Ben Schöttker</name><affiliation wicri:level="3"><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Engmann, Jorgen" sort="Engmann, Jorgen" uniqKey="Engmann J" first="Jorgen" last="Engmann">Jorgen Engmann</name><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology and Public Health, University College London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Public Health, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Kj Rgaard, Marie" sort="Kj Rgaard, Marie" uniqKey="Kj Rgaard M" first="Marie" last="Kj Rgaard">Marie Kj Rgaard</name><affiliation wicri:level="1"><nlm:affiliation>Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Division of Internal Medicine, University Hospital of North Norway, Tromsø</wicri:regionArea><wicri:noRegion>Tromsø</wicri:noRegion></affiliation></author><author><name sortKey="Karhunen, Ville" sort="Karhunen, Ville" uniqKey="Karhunen V" first="Ville" last="Karhunen">Ville Karhunen</name><affiliation wicri:level="1"><nlm:affiliation>Center for Life Course Health Research, University of Oulu, Oulu, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Center for Life Course Health Research, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Zhan, Yiqiang" sort="Zhan, Yiqiang" uniqKey="Zhan Y" first="Yiqiang" last="Zhan">Yiqiang Zhan</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Life Sciences, University of Tampere, Tampere</wicri:regionArea><wicri:noRegion>Tampere</wicri:noRegion></affiliation></author><author><name sortKey="Rovio, Suvi P" sort="Rovio, Suvi P" uniqKey="Rovio S" first="Suvi P" last="Rovio">Suvi P. Rovio</name><affiliation wicri:level="4"><nlm:affiliation>Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku</wicri:regionArea><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region><settlement type="city">Turku</settlement></placeName><orgName type="university">Université de Turku</orgName></affiliation></author><author><name sortKey="Byberg, Liisa" sort="Byberg, Liisa" uniqKey="Byberg L" first="Liisa" last="Byberg">Liisa Byberg</name><affiliation wicri:level="4"><nlm:affiliation>Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Surgical Sciences, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Psychology and Logopedics, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Marques Vidal, Pedro" sort="Marques Vidal, Pedro" uniqKey="Marques Vidal P" first="Pedro" last="Marques-Vidal">Pedro Marques-Vidal</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Sen, Abhijit" sort="Sen, Abhijit" uniqKey="Sen A" first="Abhijit" last="Sen">Abhijit Sen</name><affiliation wicri:level="3"><nlm:affiliation>Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim</wicri:regionArea><placeName><settlement type="city">Trondheim</settlement><region type="région" nuts="2">Trøndelag</region></placeName></affiliation></author><author><name sortKey="Perna, Laura" sort="Perna, Laura" uniqKey="Perna L" first="Laura" last="Perna">Laura Perna</name><affiliation wicri:level="3"><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Schirmer, Henrik" sort="Schirmer, Henrik" uniqKey="Schirmer H" first="Henrik" last="Schirmer">Henrik Schirmer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø</wicri:regionArea><wicri:noRegion>Tromsø</wicri:noRegion></affiliation></author><author><name sortKey="Singh Manoux, Archana" sort="Singh Manoux, Archana" uniqKey="Singh Manoux A" first="Archana" last="Singh-Manoux">Archana Singh-Manoux</name><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology and Public Health, University College London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Public Health, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Auvinen, Juha" sort="Auvinen, Juha" uniqKey="Auvinen J" first="Juha" last="Auvinen">Juha Auvinen</name><affiliation wicri:level="1"><nlm:affiliation>Center for Life Course Health Research, University of Oulu, Oulu, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Center for Life Course Health Research, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Hutri K Honen, Nina" sort="Hutri K Honen, Nina" uniqKey="Hutri K Honen N" first="Nina" last="Hutri-K Hönen">Nina Hutri-K Hönen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Pediatrics, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere</wicri:regionArea><wicri:noRegion>Tampere</wicri:noRegion></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere</wicri:regionArea><wicri:noRegion>Tampere</wicri:noRegion></affiliation></author><author><name sortKey="Kilander, Lena" sort="Kilander, Lena" uniqKey="Kilander L" first="Lena" last="Kilander">Lena Kilander</name><affiliation wicri:level="4"><nlm:affiliation>Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Public Health and Caring Sciences, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="R Ikkonen, Katri" sort="R Ikkonen, Katri" uniqKey="R Ikkonen K" first="Katri" last="R Ikkönen">Katri R Ikkönen</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Psychology and Logopedics, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Melhus, H Kan" sort="Melhus, H Kan" uniqKey="Melhus H" first="H Kan" last="Melhus">H Kan Melhus</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Guessous, Idris" sort="Guessous, Idris" uniqKey="Guessous I" first="Idris" last="Guessous">Idris Guessous</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Population Epidemiology, Division of Primary Care Medicine, Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University Hospitals, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Unit of Population Epidemiology, Division of Primary Care Medicine, Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University Hospitals, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Petrovic, Katja E" sort="Petrovic, Katja E" uniqKey="Petrovic K" first="Katja E" last="Petrovic">Katja E. Petrovic</name><affiliation wicri:level="1"><nlm:affiliation>Division of General Neurology, Department of Neurology, General Hospital and Medical University of Graz, Graz, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of General Neurology, Department of Neurology, General Hospital and Medical University of Graz, Graz</wicri:regionArea><wicri:noRegion>Graz</wicri:noRegion></affiliation></author><author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><affiliation wicri:level="1"><nlm:affiliation>Research Unit for Genetic Epidemiology, Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Graz, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Research Unit for Genetic Epidemiology, Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Graz</wicri:regionArea><wicri:noRegion>Graz</wicri:noRegion></affiliation></author><author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz</wicri:regionArea><wicri:noRegion>Graz</wicri:noRegion></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G" last="Eriksson">Johan G. Eriksson</name><affiliation wicri:level="1"><nlm:affiliation>Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, University of Helsinki, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, University of Helsinki, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Michaelsson, Karl" sort="Michaelsson, Karl" uniqKey="Michaelsson K" first="Karl" last="Michaëlsson">Karl Michaëlsson</name><affiliation wicri:level="4"><nlm:affiliation>Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Surgical Sciences, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Raitakari, Olli T" sort="Raitakari, Olli T" uniqKey="Raitakari O" first="Olli T" last="Raitakari">Olli T. Raitakari</name><affiliation wicri:level="4"><nlm:affiliation>Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku</wicri:regionArea><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region><settlement type="city">Turku</settlement></placeName><orgName type="university">Université de Turku</orgName></affiliation></author><author><name sortKey="H Gg, Sara" sort="H Gg, Sara" uniqKey="H Gg S" first="Sara" last="H Gg">Sara H Gg</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Pedersen, Nancy L" sort="Pedersen, Nancy L" uniqKey="Pedersen N" first="Nancy L" last="Pedersen">Nancy L. Pedersen</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Herzig, Karl Heinz" sort="Herzig, Karl Heinz" uniqKey="Herzig K" first="Karl-Heinz" last="Herzig">Karl-Heinz Herzig</name><affiliation wicri:level="1"><nlm:affiliation>Research Unit of Biomedicine, University of Oulu, Oulu, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Research Unit of Biomedicine, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="J Rvelin, Marjo Riitta" sort="J Rvelin, Marjo Riitta" uniqKey="J Rvelin M" first="Marjo-Riitta" last="J Rvelin">Marjo-Riitta J Rvelin</name><affiliation wicri:level="1"><nlm:affiliation>Center for Life Course Health Research, University of Oulu, Oulu, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Center for Life Course Health Research, University of Oulu, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Veijola, Juha" sort="Veijola, Juha" uniqKey="Veijola J" first="Juha" last="Veijola">Juha Veijola</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Center (MRC) and Oulu University Hospital, Oulu, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Medical Research Center (MRC) and Oulu University Hospital, Oulu</wicri:regionArea><wicri:noRegion>Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Kivimaki, Mika" sort="Kivimaki, Mika" uniqKey="Kivimaki M" first="Mika" last="Kivimaki">Mika Kivimaki</name><affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology and Public Health, University College London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Public Health, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Jorde, Rolf" sort="Jorde, Rolf" uniqKey="Jorde R" first="Rolf" last="Jorde">Rolf Jorde</name><affiliation wicri:level="1"><nlm:affiliation>Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Division of Internal Medicine, University Hospital of North Norway, Tromsø</wicri:regionArea><wicri:noRegion>Tromsø</wicri:noRegion></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="3"><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Kumari, Meena" sort="Kumari, Meena" uniqKey="Kumari M" first="Meena" last="Kumari">Meena Kumari</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Social and Economic Research (ISER), University of Essex, Colchester, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute for Social and Economic Research (ISER), University of Essex, Colchester</wicri:regionArea><wicri:noRegion>Colchester</wicri:noRegion></affiliation></author><author><name sortKey="Power, Chris" sort="Power, Chris" uniqKey="Power C" first="Chris" last="Power">Chris Power</name><affiliation wicri:level="3"><nlm:affiliation>Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Llewellyn, David J" sort="Llewellyn, David J" uniqKey="Llewellyn D" first="David J" last="Llewellyn">David J. Llewellyn</name><affiliation wicri:level="1"><nlm:affiliation>University of Exeter Medical School, Exeter, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Exeter Medical School, Exeter</wicri:regionArea><wicri:noRegion>Exeter</wicri:noRegion></affiliation></author><author><name sortKey="Hypponen, Elina" sort="Hypponen, Elina" uniqKey="Hypponen E" first="Elina" last="Hyppönen">Elina Hyppönen</name><affiliation wicri:level="3"><nlm:affiliation>Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, United Kingdom. elina.hypponen@unisa.edu.au.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j">Scientific reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The causal nature of the association between hypovitaminosis D and poor cognitive function in mid- to later-life is uncertain. Using a Mendelian randomisation(MR) approach, we examined the causal relationship between 25(OH)D and cognitive function. Data came from 172,349 participants from 17 cohorts. DHCR7(rs12785878), CYP2R1 rs12794714) and their combined synthesis score were chosen to proxy 25(OH)D. Cognitive tests were standardised into global and memory scores. Analyses were stratified by 25(OH)D tertiles, sex and age. Random effects meta-analyses assessed associations between 25(OH)D and cognitive function. Associations of serum 25(OH)D with global and memory-related cognitive function were non-linear (lower cognitive scores for both low and high 25(OH)D, p curvature ≤ 0.006), with much of the curvature attributed to a single study. DHCR7, CYP2R1, and the synthesis score were associated with small reductions in 25(OH)D per vitamin D-decreasing allele. However, coefficients for associations with global or memory-related cognitive function were non-significant and in opposing directions for DHCR7 and CYP2R1, with no overall association observed for the synthesis score. Coefficients for the synthesis score and global and memory cognition were similar when stratified by 25(OH)D tertiles, sex and age. We found no evidence for serum 25(OH)D concentration as a causal factor for cognitive performance in mid- to later life.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">29038561</PMID><DateCreated><Year>2017</Year><Month>10</Month><Day>17</Day></DateCreated><DateRevised><Year>2017</Year><Month>11</Month><Day>18</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2045-2322</ISSN><JournalIssue CitedMedium="Internet"><Volume>7</Volume><Issue>1</Issue><PubDate><Year>2017</Year><Month>Oct</Month><Day>16</Day></PubDate></JournalIssue><Title>Scientific reports</Title><ISOAbbreviation>Sci Rep</ISOAbbreviation></Journal><ArticleTitle>Vitamin D and cognitive function: A Mendelian randomisation study.</ArticleTitle><Pagination><MedlinePgn>13230</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/s41598-017-13189-3</ELocationID><Abstract><AbstractText>The causal nature of the association between hypovitaminosis D and poor cognitive function in mid- to later-life is uncertain. Using a Mendelian randomisation(MR) approach, we examined the causal relationship between 25(OH)D and cognitive function. Data came from 172,349 participants from 17 cohorts. DHCR7(rs12785878), CYP2R1 rs12794714) and their combined synthesis score were chosen to proxy 25(OH)D. Cognitive tests were standardised into global and memory scores. Analyses were stratified by 25(OH)D tertiles, sex and age. Random effects meta-analyses assessed associations between 25(OH)D and cognitive function. Associations of serum 25(OH)D with global and memory-related cognitive function were non-linear (lower cognitive scores for both low and high 25(OH)D, p curvature ≤ 0.006), with much of the curvature attributed to a single study. DHCR7, CYP2R1, and the synthesis score were associated with small reductions in 25(OH)D per vitamin D-decreasing allele. However, coefficients for associations with global or memory-related cognitive function were non-significant and in opposing directions for DHCR7 and CYP2R1, with no overall association observed for the synthesis score. Coefficients for the synthesis score and global and memory cognition were similar when stratified by 25(OH)D tertiles, sex and age. We found no evidence for serum 25(OH)D concentration as a causal factor for cognitive performance in mid- to later life.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Maddock</LastName><ForeName>Jane</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>MRC Lifelong Health and Ageing at UCL, London, United Kingdom. jane.maddock@ucl.ac.uk.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, United Kingdom. jane.maddock@ucl.ac.uk.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Ang</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Centre for Population Health Research, Sansom Institute, University of South Australia, Adelaide, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cavadino</LastName><ForeName>Alana</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kuźma</LastName><ForeName>Elżbieta</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>University of Exeter Medical School, Exeter, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bao</LastName><ForeName>Yanchun</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Institute for Social and Economic Research (ISER), University of Essex, Colchester, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smart</LastName><ForeName>Melissa C</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Institute for Social and Economic Research (ISER), University of Essex, Colchester, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saum</LastName><ForeName>Kai-Uwe</ForeName><Initials>KU</Initials><AffiliationInfo><Affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schöttker</LastName><ForeName>Ben</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Network Aging Research (NAR), University of Heidelberg, Heidelberg, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Health Care and Social Sciences, FOM University, Essen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Engmann</LastName><ForeName>Jorgen</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Public Health, University College London, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kjærgaard</LastName><ForeName>Marie</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Endocrinology Research Group, Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Karhunen</LastName><ForeName>Ville</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Center for Life Course Health Research, University of Oulu, Oulu, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Oulu University Hospital, Oulu, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhan</LastName><ForeName>Yiqiang</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lehtimäki</LastName><ForeName>Terho</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rovio</LastName><ForeName>Suvi P</ForeName><Initials>SP</Initials><AffiliationInfo><Affiliation>Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Byberg</LastName><ForeName>Liisa</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lahti</LastName><ForeName>Jari</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Helsinki Collegium for Advanced Studies, University of Helsinki, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marques-Vidal</LastName><ForeName>Pedro</ForeName><Initials>P</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-4548-8500</Identifier><AffiliationInfo><Affiliation>Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sen</LastName><ForeName>Abhijit</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Perna</LastName><ForeName>Laura</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schirmer</LastName><ForeName>Henrik</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Cardiology, Akershus University Hospital, Lørenskog, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Singh-Manoux</LastName><ForeName>Archana</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Public Health, University College London, London, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM, U1018, Centre for Research in Epidemiology and Population Health, Hôpital Paul Brousse, Villejuif, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Auvinen</LastName><ForeName>Juha</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Center for Life Course Health Research, University of Oulu, Oulu, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Oulu University Hospital, Oulu, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hutri-Kähönen</LastName><ForeName>Nina</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kähönen</LastName><ForeName>Mika</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kilander</LastName><ForeName>Lena</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Räikkönen</LastName><ForeName>Katri</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Melhus</LastName><ForeName>Håkan</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ingelsson</LastName><ForeName>Erik</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guessous</LastName><ForeName>Idris</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Unit of Population Epidemiology, Division of Primary Care Medicine, Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University Hospitals, Geneva, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Ambulatory Care and Community Medicine, University of Lausanne, Lausanne, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Petrovic</LastName><ForeName>Katja E</ForeName><Initials>KE</Initials><AffiliationInfo><Affiliation>Division of General Neurology, Department of Neurology, General Hospital and Medical University of Graz, Graz, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmidt</LastName><ForeName>Helena</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Research Unit for Genetic Epidemiology, Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Graz, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmidt</LastName><ForeName>Reinhold</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vollenweider</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lind</LastName><ForeName>Lars</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eriksson</LastName><ForeName>Johan G</ForeName><Initials>JG</Initials><AffiliationInfo><Affiliation>Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, University of Helsinki, Helsinki, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Folkhälsan Research Center, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Michaëlsson</LastName><ForeName>Karl</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Raitakari</LastName><ForeName>Olli T</ForeName><Initials>OT</Initials><AffiliationInfo><Affiliation>Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hägg</LastName><ForeName>Sara</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pedersen</LastName><ForeName>Nancy L</ForeName><Initials>NL</Initials><AffiliationInfo><Affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Herzig</LastName><ForeName>Karl-Heinz</ForeName><Initials>KH</Initials><AffiliationInfo><Affiliation>Research Unit of Biomedicine, University of Oulu, Oulu, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Biocenter Oulu, University of Oulu, Oulu, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Medical Research Center (MRC) and Oulu University Hospital, Oulu, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznan, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Järvelin</LastName><ForeName>Marjo-Riitta</ForeName><Initials>MR</Initials><AffiliationInfo><Affiliation>Center for Life Course Health Research, University of Oulu, Oulu, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Veijola</LastName><ForeName>Juha</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Medical Research Center (MRC) and Oulu University Hospital, Oulu, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Research Unit of Clinical Neuroscience, Department of Psychiatry, University of Oulu, Oulu, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Psychiatry, University Hospital of Oulu, Oulu, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kivimaki</LastName><ForeName>Mika</ForeName><Initials>M</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-4699-5627</Identifier><AffiliationInfo><Affiliation>Department of Epidemiology and Public Health, University College London, London, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Clinicum, University of Helsinki, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jorde</LastName><ForeName>Rolf</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Endocrinology Research Group, Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brenner</LastName><ForeName>Hermann</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Network Aging Research (NAR), University of Heidelberg, Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kumari</LastName><ForeName>Meena</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute for Social and Economic Research (ISER), University of Essex, Colchester, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology and Public Health, University College London, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Power</LastName><ForeName>Chris</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Llewellyn</LastName><ForeName>David J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>University of Exeter Medical School, Exeter, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hyppönen</LastName><ForeName>Elina</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, United Kingdom. elina.hypponen@unisa.edu.au.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Population Health Research, Sansom Institute, University of South Australia, Adelaide, Australia. elina.hypponen@unisa.edu.au.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>South Australian Health and Medical Research Institute, Adelaide, Australia. elina.hypponen@unisa.edu.au.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 HL135313</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>10</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Sci Rep</MedlineTA><NlmUniqueID>101563288</NlmUniqueID><ISSNLinking>2045-2322</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4135-7</RefSource><PMID Version="1">11929987</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Nutr Health Aging. 2009 Nov;13(9):760-7</RefSource><PMID Version="1">19812865</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2007 Jul 19;357(3):266-81</RefSource><PMID Version="1">17634462</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br J Nutr. 2014 Mar 14;111(5):904-14</RefSource><PMID Version="1">24135155</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Alzheimers Dis. 2011;26(3):477-84</RefSource><PMID Version="1">21694461</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ageing Res Rev. 2013 Sep;12(4):1013-23</RefSource><PMID Version="1">23727408</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2016 Dec 13;87(24):2567-2574</RefSource><PMID Version="1">27856775</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Am Geriatr Soc. 2012 Dec;60(12):2197-205</RefSource><PMID Version="1">23176129</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Am Geriatr Soc. 2012 Apr;60(4):793-5</RefSource><PMID Version="1">22494292</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2012 Sep 25;79(13):1397-405</RefSource><PMID Version="1">23008220</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Intern Med. 2015 Jan;277(1):45-57</RefSource><PMID Version="1">24995480</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trends Endocrinol Metab. 2002 Apr;13(3):100-5</RefSource><PMID Version="1">11893522</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Audiol Neurootol. 2008;13(4):219-30</RefSource><PMID Version="1">18259074</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>BMC Geriatr. 2017 Jan 13;17 (1):16</RefSource><PMID Version="1">28086755</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Steroid Biochem Mol Biol. 2009 Jul;115(3-5):91-7</RefSource><PMID Version="1">19500727</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2011;6(11):e25966</RefSource><PMID Version="1">22073146</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Alzheimers Dis. 2013;37(1):147-71</RefSource><PMID Version="1">23948884</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Osteoporos Int. 2008 Nov;19(11):1621-8</RefSource><PMID Version="1">18421544</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Dement Geriatr Cogn Disord. 2012;33(5):297-305</RefSource><PMID Version="1">22759681</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Alzheimers Dement. 2013 Jan;9(1):63-75.e2</RefSource><PMID Version="1">23305823</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hum Mol Genet. 2010 Jul 1;19(13):2739-45</RefSource><PMID Version="1">20418485</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2012;7(5):e37465</RefSource><PMID Version="1">22629401</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Neurol. 2009 Oct;16(10):1083-9</RefSource><PMID Version="1">19659751</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Stat Med. 2008 Apr 15;27(8):1133-63</RefSource><PMID Version="1">17886233</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Curr Opin Nephrol Hypertens. 2011 Jul;20(4):331-6</RefSource><PMID Version="1">21654390</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Front Aging Neurosci. 2014 Apr 15;6:72</RefSource><PMID Version="1">24782767</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain Res Bull. 2004 Jul 30;64(1):25-9</RefSource><PMID Version="1">15275953</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>BMJ. 2014 Apr 01;348:g1903</RefSource><PMID Version="1">24690623</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurosci Lett. 2003 Jun 5;343(2):139-43</RefSource><PMID Version="1">12759183</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Am Geriatr Soc. 2013 Jun;61(6):1049-50</RefSource><PMID Version="1">23772744</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2010 Jul 17;376(9736):180-8</RefSource><PMID Version="1">20541252</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Behav Brain Res. 2005 Feb 28;157(2):299-308</RefSource><PMID Version="1">15639181</PMID></CommentsCorrections></CommentsCorrectionsList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>05</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>09</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>10</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>10</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>10</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29038561</ArticleId><ArticleId IdType="doi">10.1038/s41598-017-13189-3</ArticleId><ArticleId IdType="pii">10.1038/s41598-017-13189-3</ArticleId><ArticleId IdType="pmc">PMC5643555</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Autriche</li><li>Finlande</li><li>Norvège</li><li>Royaume-Uni</li><li>Suisse</li><li>Suède</li></country><region><li>Angleterre</li><li>Bade-Wurtemberg</li><li>Canton de Vaud</li><li>District de Karlsruhe</li><li>East Middle Sweden</li><li>Finlande occidentale</li><li>Grand Londres</li><li>Svealand</li><li>Trøndelag</li><li>Uusimaa</li></region><settlement><li>Heidelberg</li><li>Helsinki</li><li>Lausanne</li><li>Londres</li><li>Stockholm</li><li>Trondheim</li><li>Turku</li><li>Uppsala</li></settlement><orgName><li>University College de Londres</li><li>Université d'Helsinki</li><li>Université d'Uppsala</li><li>Université de Turku</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Maddock, Jane" sort="Maddock, Jane" uniqKey="Maddock J" first="Jane" last="Maddock">Jane Maddock</name></region><name sortKey="Bao, Yanchun" sort="Bao, Yanchun" uniqKey="Bao Y" first="Yanchun" last="Bao">Yanchun Bao</name><name sortKey="Cavadino, Alana" sort="Cavadino, Alana" uniqKey="Cavadino A" first="Alana" last="Cavadino">Alana Cavadino</name><name sortKey="Engmann, Jorgen" sort="Engmann, Jorgen" uniqKey="Engmann J" first="Jorgen" last="Engmann">Jorgen Engmann</name><name sortKey="Hypponen, Elina" sort="Hypponen, Elina" uniqKey="Hypponen E" first="Elina" last="Hyppönen">Elina Hyppönen</name><name sortKey="Kivimaki, Mika" sort="Kivimaki, Mika" uniqKey="Kivimaki M" first="Mika" last="Kivimaki">Mika Kivimaki</name><name sortKey="Ku Ma, El Bieta" sort="Ku Ma, El Bieta" uniqKey="Ku Ma E" first="El Bieta" last="Ku Ma">El Bieta Ku Ma</name><name sortKey="Kumari, Meena" sort="Kumari, Meena" uniqKey="Kumari M" first="Meena" last="Kumari">Meena Kumari</name><name sortKey="Llewellyn, David J" sort="Llewellyn, David J" uniqKey="Llewellyn D" first="David J" last="Llewellyn">David J. Llewellyn</name><name sortKey="Power, Chris" sort="Power, Chris" uniqKey="Power C" first="Chris" last="Power">Chris Power</name><name sortKey="Singh Manoux, Archana" sort="Singh Manoux, Archana" uniqKey="Singh Manoux A" first="Archana" last="Singh-Manoux">Archana Singh-Manoux</name><name sortKey="Smart, Melissa C" sort="Smart, Melissa C" uniqKey="Smart M" first="Melissa C" last="Smart">Melissa C. Smart</name></country><country name="Australie"><noRegion><name sortKey="Zhou, Ang" sort="Zhou, Ang" uniqKey="Zhou A" first="Ang" last="Zhou">Ang Zhou</name></noRegion></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Saum, Kai Uwe" sort="Saum, Kai Uwe" uniqKey="Saum K" first="Kai-Uwe" last="Saum">Kai-Uwe Saum</name></region><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><name sortKey="Perna, Laura" sort="Perna, Laura" uniqKey="Perna L" first="Laura" last="Perna">Laura Perna</name><name sortKey="Schottker, Ben" sort="Schottker, Ben" uniqKey="Schottker B" first="Ben" last="Schöttker">Ben Schöttker</name></country><country name="Norvège"><noRegion><name sortKey="Kj Rgaard, Marie" sort="Kj Rgaard, Marie" uniqKey="Kj Rgaard M" first="Marie" last="Kj Rgaard">Marie Kj Rgaard</name></noRegion><name sortKey="Jorde, Rolf" sort="Jorde, Rolf" uniqKey="Jorde R" first="Rolf" last="Jorde">Rolf Jorde</name><name sortKey="Schirmer, Henrik" sort="Schirmer, Henrik" uniqKey="Schirmer H" first="Henrik" last="Schirmer">Henrik Schirmer</name><name sortKey="Sen, Abhijit" sort="Sen, Abhijit" uniqKey="Sen A" first="Abhijit" last="Sen">Abhijit Sen</name></country><country name="Finlande"><noRegion><name sortKey="Karhunen, Ville" sort="Karhunen, Ville" uniqKey="Karhunen V" first="Ville" last="Karhunen">Ville Karhunen</name></noRegion><name sortKey="Auvinen, Juha" sort="Auvinen, Juha" uniqKey="Auvinen J" first="Juha" last="Auvinen">Juha Auvinen</name><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G" last="Eriksson">Johan G. Eriksson</name><name sortKey="Herzig, Karl Heinz" sort="Herzig, Karl Heinz" uniqKey="Herzig K" first="Karl-Heinz" last="Herzig">Karl-Heinz Herzig</name><name sortKey="Hutri K Honen, Nina" sort="Hutri K Honen, Nina" uniqKey="Hutri K Honen N" first="Nina" last="Hutri-K Hönen">Nina Hutri-K Hönen</name><name sortKey="J Rvelin, Marjo Riitta" sort="J Rvelin, Marjo Riitta" uniqKey="J Rvelin M" first="Marjo-Riitta" last="J Rvelin">Marjo-Riitta J Rvelin</name><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><name sortKey="R Ikkonen, Katri" sort="R Ikkonen, Katri" uniqKey="R Ikkonen K" first="Katri" last="R Ikkönen">Katri R Ikkönen</name><name sortKey="Raitakari, Olli T" sort="Raitakari, Olli T" uniqKey="Raitakari O" first="Olli T" last="Raitakari">Olli T. Raitakari</name><name sortKey="Rovio, Suvi P" sort="Rovio, Suvi P" uniqKey="Rovio S" first="Suvi P" last="Rovio">Suvi P. Rovio</name><name sortKey="Veijola, Juha" sort="Veijola, Juha" uniqKey="Veijola J" first="Juha" last="Veijola">Juha Veijola</name></country><country name="Suède"><region name="Svealand"><name sortKey="Zhan, Yiqiang" sort="Zhan, Yiqiang" uniqKey="Zhan Y" first="Yiqiang" last="Zhan">Yiqiang Zhan</name></region><name sortKey="Byberg, Liisa" sort="Byberg, Liisa" uniqKey="Byberg L" first="Liisa" last="Byberg">Liisa Byberg</name><name sortKey="H Gg, Sara" sort="H Gg, Sara" uniqKey="H Gg S" first="Sara" last="H Gg">Sara H Gg</name><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><name sortKey="Kilander, Lena" sort="Kilander, Lena" uniqKey="Kilander L" first="Lena" last="Kilander">Lena Kilander</name><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name><name sortKey="Melhus, H Kan" sort="Melhus, H Kan" uniqKey="Melhus H" first="H Kan" last="Melhus">H Kan Melhus</name><name sortKey="Michaelsson, Karl" sort="Michaelsson, Karl" uniqKey="Michaelsson K" first="Karl" last="Michaëlsson">Karl Michaëlsson</name><name sortKey="Pedersen, Nancy L" sort="Pedersen, Nancy L" uniqKey="Pedersen N" first="Nancy L" last="Pedersen">Nancy L. Pedersen</name></country><country name="Suisse"><region name="Canton de Vaud"><name sortKey="Marques Vidal, Pedro" sort="Marques Vidal, Pedro" uniqKey="Marques Vidal P" first="Pedro" last="Marques-Vidal">Pedro Marques-Vidal</name></region><name sortKey="Guessous, Idris" sort="Guessous, Idris" uniqKey="Guessous I" first="Idris" last="Guessous">Idris Guessous</name><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name></country><country name="Autriche"><noRegion><name sortKey="Petrovic, Katja E" sort="Petrovic, Katja E" uniqKey="Petrovic K" first="Katja E" last="Petrovic">Katja E. Petrovic</name></noRegion><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000036 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000036 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= PubMed
|étape= Checkpoint
|type= RBID
|clé= pubmed:29038561
|texte= Vitamin D and cognitive function: A Mendelian randomisation study.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:29038561" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |