Islet Product Characteristics and Factors Related to Successful Human Islet Transplantation From the Collaborative Islet Transplant Registry (CITR) 1999–2010
Identifieur interne : 002084 ( Pmc/Curation ); précédent : 002083; suivant : 002085Islet Product Characteristics and Factors Related to Successful Human Islet Transplantation From the Collaborative Islet Transplant Registry (CITR) 1999–2010
Auteurs : A N Balamurugan [États-Unis] ; B. Naziruddin [États-Unis] ; A. Lockridge [États-Unis] ; M. Tiwari [États-Unis] ; G. Loganathan [États-Unis] ; M. Takita [États-Unis] ; S. Matsumoto [Japon] ; K. Papas [États-Unis] ; M. Trieger [États-Unis] ; H. Rainis [États-Unis] ; T. Kin ; T W Kay [Australie] ; S. Wease [États-Unis] ; S. Messinger [États-Unis] ; C. Ricordi [États-Unis] ; R. Alejandro [États-Unis] ; J. Markmann [États-Unis] ; J. Kerr-Conti [France] ; M R Rickels [États-Unis] ; C. Liu [États-Unis] ; X. Zhang [États-Unis] ; P. Witkowski [États-Unis] ; A. Posselt [États-Unis] ; P. Maffi [Italie] ; A. Secchi [Italie] ; T. Berney [Suisse] ; P J O Onnell [Australie] ; B J Hering [États-Unis] ; F B Barton [États-Unis]Source :
- American Journal of Transplantation [ 1600-6135 ] ; 2014.
Abstract
The Collaborative Islet Transplant Registry (CITR) collects data on clinical islet isolations and transplants. This retrospective report analyzed 1017 islet isolation procedures performed for 537 recipients of allogeneic clinical islet transplantation in 1999–2010. This study describes changes in donor and islet isolation variables by era and factors associated with quantity and quality of final islet products. Donor body weight and BMI increased significantly over the period (p < 0.001). Islet yield measures have improved with time including islet equivalent (IEQ)/particle ratio and IEQs infused. The average dose of islets infused significantly increased in the era of 2007–2010 when compared to 1999–2002 (445.4 ± 156.8 vs. 421.3 ± 155.4 ×103 IEQ; p < 0.05). Islet purity and total number of β cells significantly improved over the study period (p < 0.01 and <0.05, respectively). Otherwise, the quality of clinical islets has remained consistently very high through this period, and differs substantially from nonclinical islets. In multivariate analysis of all recipient, donor and islet factors, and medical management factors, the only islet product characteristic that correlated with clinical outcomes was total IEQs infused. This analysis shows improvements in both quantity and some quality criteria of clinical islets produced over 1999–2010, and these parallel improvements in clinical outcomes over the same period.
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DOI: 10.1111/ajt.12872
PubMed: 25278159
PubMed Central: 4282081
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T. Kin<affiliation><nlm:aff id="au6"><institution>Clinical Islet Laboratory, University of Alberta</institution><addr-line>Edmonton, AB</addr-line></nlm:aff><wicri:noCountry code="subfield">AB</wicri:noCountry></affiliation>Le document en format XML
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Tiwari</name><affiliation wicri:level="2"><nlm:aff id="au1"><institution>Schulze Diabetes Institute, Department of Surgery, University of Minnesota</institution><addr-line>Minneapolis, MN</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="Loganathan, G" sort="Loganathan, G" uniqKey="Loganathan G" first="G" last="Loganathan">G. Loganathan</name><affiliation wicri:level="2"><nlm:aff id="au1"><institution>Schulze Diabetes Institute, Department of Surgery, University of Minnesota</institution><addr-line>Minneapolis, MN</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="Takita, M" sort="Takita, M" uniqKey="Takita M" first="M" last="Takita">M. Takita</name><affiliation wicri:level="2"><nlm:aff id="au2"><institution>Baylor Annette C. and Harold C. Simmons Transplant Institute</institution><addr-line>Dallas, TX</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Dallas</wicri:cityArea></affiliation></author><author><name sortKey="Matsumoto, S" sort="Matsumoto, S" uniqKey="Matsumoto S" first="S" last="Matsumoto">S. Matsumoto</name><affiliation wicri:level="1"><nlm:aff id="au3"><institution>Research and Development Center, Otsuka Pharmaceutical Factory, Inc.</institution><addr-line>Tokushima, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokushima</wicri:regionArea></affiliation></author><author><name sortKey="Papas, K" sort="Papas, K" uniqKey="Papas K" first="K" last="Papas">K. Papas</name><affiliation wicri:level="2"><nlm:aff id="au4"><institution>Institute for Cellular Transplantation, University of Arizona</institution><addr-line>Tucson, AZ</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea>Tucson</wicri:cityArea></affiliation></author><author><name sortKey="Trieger, M" sort="Trieger, M" uniqKey="Trieger M" first="M" last="Trieger">M. Trieger</name><affiliation wicri:level="2"><nlm:aff id="au5"><institution>The EMMES Corporation</institution><addr-line>Rockville, MD</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Rockville</wicri:cityArea></affiliation></author><author><name sortKey="Rainis, H" sort="Rainis, H" uniqKey="Rainis H" first="H" last="Rainis">H. Rainis</name><affiliation wicri:level="2"><nlm:aff id="au5"><institution>The EMMES Corporation</institution><addr-line>Rockville, MD</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Rockville</wicri:cityArea></affiliation></author><author><name sortKey="Kin, T" sort="Kin, T" uniqKey="Kin T" first="T" last="Kin">T. Kin</name><affiliation><nlm:aff id="au6"><institution>Clinical Islet Laboratory, University of Alberta</institution><addr-line>Edmonton, AB</addr-line></nlm:aff><wicri:noCountry code="subfield">AB</wicri:noCountry></affiliation></author><author><name sortKey="Kay, T W" sort="Kay, T W" uniqKey="Kay T" first="T W" last="Kay">T W Kay</name><affiliation wicri:level="1"><nlm:aff id="au7"><institution>St. Vincent's Hospital</institution><addr-line>Melbourne, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Wease, S" sort="Wease, S" uniqKey="Wease S" first="S" last="Wease">S. 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Ricordi</name><affiliation wicri:level="2"><nlm:aff id="au9"><institution>Diabetes Research Institute, University of Miami</institution><addr-line>Miami, FL</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Miami</wicri:cityArea></affiliation></author><author><name sortKey="Alejandro, R" sort="Alejandro, R" uniqKey="Alejandro R" first="R" last="Alejandro">R. Alejandro</name><affiliation wicri:level="2"><nlm:aff id="au9"><institution>Diabetes Research Institute, University of Miami</institution><addr-line>Miami, FL</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Miami</wicri:cityArea></affiliation></author><author><name sortKey="Markmann, J" sort="Markmann, J" uniqKey="Markmann J" first="J" last="Markmann">J. Markmann</name><affiliation wicri:level="2"><nlm:aff id="au10"><institution>Department of Surgery, Massachusetts General Hospital</institution><addr-line>Boston, MA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Boston</wicri:cityArea></affiliation></author><author><name sortKey="Kerr Conti, J" sort="Kerr Conti, J" uniqKey="Kerr Conti J" first="J" last="Kerr-Conti">J. Kerr-Conti</name><affiliation wicri:level="1"><nlm:aff id="au11"><institution>Lille University Hospital</institution><addr-line>Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Lille</wicri:regionArea></affiliation></author><author><name sortKey="Rickels, M R" sort="Rickels, M R" uniqKey="Rickels M" first="M R" last="Rickels">M R Rickels</name><affiliation wicri:level="2"><nlm:aff id="au12"><institution>Department of Medicine, University of Pennsylvania</institution><addr-line>Philadelphia, PA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Liu, C" sort="Liu, C" uniqKey="Liu C" first="C" last="Liu">C. Liu</name><affiliation wicri:level="2"><nlm:aff id="au13"><institution>Department of Surgery, University of Pennsylvania</institution><addr-line>Philadelphia, PA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Zhang, X" sort="Zhang, X" uniqKey="Zhang X" first="X" last="Zhang">X. Zhang</name><affiliation wicri:level="2"><nlm:aff id="au14"><institution>Feinberg School of Medicine, Northwestern University</institution><addr-line>Chicago, IL</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Witkowski, P" sort="Witkowski, P" uniqKey="Witkowski P" first="P" last="Witkowski">P. Witkowski</name><affiliation wicri:level="2"><nlm:aff id="au15"><institution>Department of Surgery, University of Chicago</institution><addr-line>Chicago, IL</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Posselt, A" sort="Posselt, A" uniqKey="Posselt A" first="A" last="Posselt">A. Posselt</name><affiliation wicri:level="2"><nlm:aff id="au16"><institution>Department of Surgery, University of California, San Francisco</institution><addr-line>San Francisco, CA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Maffi, P" sort="Maffi, P" uniqKey="Maffi P" first="P" last="Maffi">P. Maffi</name><affiliation wicri:level="1"><nlm:aff id="au17"><institution>Vita-Salute, San Raffaele University</institution><addr-line>Milan, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Milan</wicri:regionArea></affiliation></author><author><name sortKey="Secchi, A" sort="Secchi, A" uniqKey="Secchi A" first="A" last="Secchi">A. Secchi</name><affiliation wicri:level="1"><nlm:aff id="au17"><institution>Vita-Salute, San Raffaele University</institution><addr-line>Milan, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Milan</wicri:regionArea></affiliation></author><author><name sortKey="Berney, T" sort="Berney, T" uniqKey="Berney T" first="T" last="Berney">T. Berney</name><affiliation wicri:level="1"><nlm:aff id="au18"><institution>Department of Surgery, Geneva University Hospital</institution><addr-line>Geneva, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Geneva</wicri:regionArea></affiliation></author><author><name sortKey="O Onnell, P J" sort="O Onnell, P J" uniqKey="O Onnell P" first="P J" last="O Onnell">P J O Onnell</name><affiliation wicri:level="1"><nlm:aff id="au19"><institution>National Pancreas Transplant Unit, University of Sydney at Westmead Hospital</institution><addr-line>Sydney, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney</wicri:regionArea></affiliation></author><author><name sortKey="Hering, B J" sort="Hering, B J" uniqKey="Hering B" first="B J" last="Hering">B J Hering</name><affiliation wicri:level="2"><nlm:aff id="au1"><institution>Schulze Diabetes Institute, Department of Surgery, University of Minnesota</institution><addr-line>Minneapolis, MN</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="Barton, F B" sort="Barton, F B" uniqKey="Barton F" first="F B" last="Barton">F B Barton</name><affiliation wicri:level="2"><nlm:aff id="au5"><institution>The EMMES Corporation</institution><addr-line>Rockville, MD</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Rockville</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25278159</idno><idno type="pmc">4282081</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282081</idno><idno type="RBID">PMC:4282081</idno><idno type="doi">10.1111/ajt.12872</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002234</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002234</idno><idno type="wicri:Area/Pmc/Curation">002084</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002084</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Islet Product Characteristics and Factors Related to Successful Human Islet Transplantation From the Collaborative Islet Transplant Registry (CITR) 1999–2010</title><author><name sortKey="Balamurugan, A N" sort="Balamurugan, A N" uniqKey="Balamurugan A" first="A N" last="Balamurugan">A N Balamurugan</name><affiliation wicri:level="2"><nlm:aff id="au1"><institution>Schulze Diabetes Institute, Department of Surgery, University of Minnesota</institution><addr-line>Minneapolis, MN</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="Naziruddin, B" sort="Naziruddin, B" uniqKey="Naziruddin B" first="B" last="Naziruddin">B. Naziruddin</name><affiliation wicri:level="2"><nlm:aff id="au2"><institution>Baylor Annette C. and Harold C. Simmons Transplant Institute</institution><addr-line>Dallas, TX</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Dallas</wicri:cityArea></affiliation></author><author><name sortKey="Lockridge, A" sort="Lockridge, A" uniqKey="Lockridge A" first="A" last="Lockridge">A. Lockridge</name><affiliation wicri:level="2"><nlm:aff id="au1"><institution>Schulze Diabetes Institute, Department of Surgery, University of Minnesota</institution><addr-line>Minneapolis, MN</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="Tiwari, M" sort="Tiwari, M" uniqKey="Tiwari M" first="M" last="Tiwari">M. Tiwari</name><affiliation wicri:level="2"><nlm:aff id="au1"><institution>Schulze Diabetes Institute, Department of Surgery, University of Minnesota</institution><addr-line>Minneapolis, MN</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="Loganathan, G" sort="Loganathan, G" uniqKey="Loganathan G" first="G" last="Loganathan">G. Loganathan</name><affiliation wicri:level="2"><nlm:aff id="au1"><institution>Schulze Diabetes Institute, Department of Surgery, University of Minnesota</institution><addr-line>Minneapolis, MN</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="Takita, M" sort="Takita, M" uniqKey="Takita M" first="M" last="Takita">M. Takita</name><affiliation wicri:level="2"><nlm:aff id="au2"><institution>Baylor Annette C. and Harold C. Simmons Transplant Institute</institution><addr-line>Dallas, TX</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Dallas</wicri:cityArea></affiliation></author><author><name sortKey="Matsumoto, S" sort="Matsumoto, S" uniqKey="Matsumoto S" first="S" last="Matsumoto">S. Matsumoto</name><affiliation wicri:level="1"><nlm:aff id="au3"><institution>Research and Development Center, Otsuka Pharmaceutical Factory, Inc.</institution><addr-line>Tokushima, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokushima</wicri:regionArea></affiliation></author><author><name sortKey="Papas, K" sort="Papas, K" uniqKey="Papas K" first="K" last="Papas">K. Papas</name><affiliation wicri:level="2"><nlm:aff id="au4"><institution>Institute for Cellular Transplantation, University of Arizona</institution><addr-line>Tucson, AZ</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea>Tucson</wicri:cityArea></affiliation></author><author><name sortKey="Trieger, M" sort="Trieger, M" uniqKey="Trieger M" first="M" last="Trieger">M. Trieger</name><affiliation wicri:level="2"><nlm:aff id="au5"><institution>The EMMES Corporation</institution><addr-line>Rockville, MD</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Rockville</wicri:cityArea></affiliation></author><author><name sortKey="Rainis, H" sort="Rainis, H" uniqKey="Rainis H" first="H" last="Rainis">H. Rainis</name><affiliation wicri:level="2"><nlm:aff id="au5"><institution>The EMMES Corporation</institution><addr-line>Rockville, MD</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Rockville</wicri:cityArea></affiliation></author><author><name sortKey="Kin, T" sort="Kin, T" uniqKey="Kin T" first="T" last="Kin">T. Kin</name><affiliation><nlm:aff id="au6"><institution>Clinical Islet Laboratory, University of Alberta</institution><addr-line>Edmonton, AB</addr-line></nlm:aff><wicri:noCountry code="subfield">AB</wicri:noCountry></affiliation></author><author><name sortKey="Kay, T W" sort="Kay, T W" uniqKey="Kay T" first="T W" last="Kay">T W Kay</name><affiliation wicri:level="1"><nlm:aff id="au7"><institution>St. Vincent's Hospital</institution><addr-line>Melbourne, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Wease, S" sort="Wease, S" uniqKey="Wease S" first="S" last="Wease">S. Wease</name><affiliation wicri:level="2"><nlm:aff id="au5"><institution>The EMMES Corporation</institution><addr-line>Rockville, MD</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Rockville</wicri:cityArea></affiliation></author><author><name sortKey="Messinger, S" sort="Messinger, S" uniqKey="Messinger S" first="S" last="Messinger">S. Messinger</name><affiliation wicri:level="2"><nlm:aff id="au8"><institution>Department of Public Health Services, University of Miami</institution><addr-line>Miami, FL</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Miami</wicri:cityArea></affiliation></author><author><name sortKey="Ricordi, C" sort="Ricordi, C" uniqKey="Ricordi C" first="C" last="Ricordi">C. Ricordi</name><affiliation wicri:level="2"><nlm:aff id="au9"><institution>Diabetes Research Institute, University of Miami</institution><addr-line>Miami, FL</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Miami</wicri:cityArea></affiliation></author><author><name sortKey="Alejandro, R" sort="Alejandro, R" uniqKey="Alejandro R" first="R" last="Alejandro">R. Alejandro</name><affiliation wicri:level="2"><nlm:aff id="au9"><institution>Diabetes Research Institute, University of Miami</institution><addr-line>Miami, FL</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Miami</wicri:cityArea></affiliation></author><author><name sortKey="Markmann, J" sort="Markmann, J" uniqKey="Markmann J" first="J" last="Markmann">J. Markmann</name><affiliation wicri:level="2"><nlm:aff id="au10"><institution>Department of Surgery, Massachusetts General Hospital</institution><addr-line>Boston, MA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Boston</wicri:cityArea></affiliation></author><author><name sortKey="Kerr Conti, J" sort="Kerr Conti, J" uniqKey="Kerr Conti J" first="J" last="Kerr-Conti">J. Kerr-Conti</name><affiliation wicri:level="1"><nlm:aff id="au11"><institution>Lille University Hospital</institution><addr-line>Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Lille</wicri:regionArea></affiliation></author><author><name sortKey="Rickels, M R" sort="Rickels, M R" uniqKey="Rickels M" first="M R" last="Rickels">M R Rickels</name><affiliation wicri:level="2"><nlm:aff id="au12"><institution>Department of Medicine, University of Pennsylvania</institution><addr-line>Philadelphia, PA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Liu, C" sort="Liu, C" uniqKey="Liu C" first="C" last="Liu">C. Liu</name><affiliation wicri:level="2"><nlm:aff id="au13"><institution>Department of Surgery, University of Pennsylvania</institution><addr-line>Philadelphia, PA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Zhang, X" sort="Zhang, X" uniqKey="Zhang X" first="X" last="Zhang">X. Zhang</name><affiliation wicri:level="2"><nlm:aff id="au14"><institution>Feinberg School of Medicine, Northwestern University</institution><addr-line>Chicago, IL</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Witkowski, P" sort="Witkowski, P" uniqKey="Witkowski P" first="P" last="Witkowski">P. Witkowski</name><affiliation wicri:level="2"><nlm:aff id="au15"><institution>Department of Surgery, University of Chicago</institution><addr-line>Chicago, IL</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Posselt, A" sort="Posselt, A" uniqKey="Posselt A" first="A" last="Posselt">A. Posselt</name><affiliation wicri:level="2"><nlm:aff id="au16"><institution>Department of Surgery, University of California, San Francisco</institution><addr-line>San Francisco, CA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Maffi, P" sort="Maffi, P" uniqKey="Maffi P" first="P" last="Maffi">P. Maffi</name><affiliation wicri:level="1"><nlm:aff id="au17"><institution>Vita-Salute, San Raffaele University</institution><addr-line>Milan, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Milan</wicri:regionArea></affiliation></author><author><name sortKey="Secchi, A" sort="Secchi, A" uniqKey="Secchi A" first="A" last="Secchi">A. Secchi</name><affiliation wicri:level="1"><nlm:aff id="au17"><institution>Vita-Salute, San Raffaele University</institution><addr-line>Milan, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Milan</wicri:regionArea></affiliation></author><author><name sortKey="Berney, T" sort="Berney, T" uniqKey="Berney T" first="T" last="Berney">T. Berney</name><affiliation wicri:level="1"><nlm:aff id="au18"><institution>Department of Surgery, Geneva University Hospital</institution><addr-line>Geneva, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Geneva</wicri:regionArea></affiliation></author><author><name sortKey="O Onnell, P J" sort="O Onnell, P J" uniqKey="O Onnell P" first="P J" last="O Onnell">P J O Onnell</name><affiliation wicri:level="1"><nlm:aff id="au19"><institution>National Pancreas Transplant Unit, University of Sydney at Westmead Hospital</institution><addr-line>Sydney, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney</wicri:regionArea></affiliation></author><author><name sortKey="Hering, B J" sort="Hering, B J" uniqKey="Hering B" first="B J" last="Hering">B J Hering</name><affiliation wicri:level="2"><nlm:aff id="au1"><institution>Schulze Diabetes Institute, Department of Surgery, University of Minnesota</institution><addr-line>Minneapolis, MN</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="Barton, F B" sort="Barton, F B" uniqKey="Barton F" first="F B" last="Barton">F B Barton</name><affiliation wicri:level="2"><nlm:aff id="au5"><institution>The EMMES Corporation</institution><addr-line>Rockville, MD</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Rockville</wicri:cityArea></affiliation></author></analytic><series><title level="j">American Journal of Transplantation</title><idno type="ISSN">1600-6135</idno><idno type="eISSN">1600-6143</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The Collaborative Islet Transplant Registry (CITR) collects data on clinical islet isolations and transplants. This retrospective report analyzed 1017 islet isolation procedures performed for 537 recipients of allogeneic clinical islet transplantation in 1999–2010. This study describes changes in donor and islet isolation variables by era and factors associated with quantity and quality of final islet products. Donor body weight and BMI increased significantly over the period (p < 0.001). Islet yield measures have improved with time including islet equivalent (IEQ)/particle ratio and IEQs infused. The average dose of islets infused significantly increased in the era of 2007–2010 when compared to 1999–2002 (445.4 ± 156.8 vs. 421.3 ± 155.4 ×10<sup>3</sup> IEQ; p < 0.05). Islet purity and total number of β cells significantly improved over the study period (p < 0.01 and <0.05, respectively). Otherwise, the quality of clinical islets has remained consistently very high through this period, and differs substantially from nonclinical islets. In multivariate analysis of all recipient, donor and islet factors, and medical management factors, the only islet product characteristic that correlated with clinical outcomes was total IEQs infused. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Am J Transplant</journal-id><journal-id journal-id-type="iso-abbrev">Am. J. Transplant</journal-id><journal-id journal-id-type="publisher-id">ajt</journal-id><journal-title-group><journal-title>American Journal of Transplantation</journal-title></journal-title-group><issn pub-type="ppub">1600-6135</issn><issn pub-type="epub">1600-6143</issn><publisher><publisher-name>BlackWell Publishing Ltd</publisher-name><publisher-loc>Oxford, UK</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25278159</article-id><article-id pub-id-type="pmc">4282081</article-id><article-id pub-id-type="doi">10.1111/ajt.12872</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Articles</subject></subj-group></article-categories><title-group><article-title>Islet Product Characteristics and Factors Related to Successful Human Islet Transplantation From the Collaborative Islet Transplant Registry (CITR) 1999–2010</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Balamurugan</surname><given-names>A N</given-names></name><xref ref-type="aff" rid="au1">1</xref><xref ref-type="corresp" rid="cor1">*</xref><xref ref-type="corresp" rid="cor2">†</xref></contrib><contrib contrib-type="author"><name><surname>Naziruddin</surname><given-names>B</given-names></name><xref ref-type="aff" rid="au2">2</xref></contrib><contrib contrib-type="author"><name><surname>Lockridge</surname><given-names>A</given-names></name><xref ref-type="aff" rid="au1">1</xref></contrib><contrib contrib-type="author"><name><surname>Tiwari</surname><given-names>M</given-names></name><xref ref-type="aff" rid="au1">1</xref></contrib><contrib contrib-type="author"><name><surname>Loganathan</surname><given-names>G</given-names></name><xref ref-type="aff" rid="au1">1</xref></contrib><contrib contrib-type="author"><name><surname>Takita</surname><given-names>M</given-names></name><xref ref-type="aff" rid="au2">2</xref></contrib><contrib contrib-type="author"><name><surname>Matsumoto</surname><given-names>S</given-names></name><xref ref-type="aff" rid="au3">3</xref></contrib><contrib contrib-type="author"><name><surname>Papas</surname><given-names>K</given-names></name><xref ref-type="aff" rid="au4">4</xref></contrib><contrib contrib-type="author"><name><surname>Trieger</surname><given-names>M</given-names></name><xref ref-type="aff" rid="au5">5</xref></contrib><contrib contrib-type="author"><name><surname>Rainis</surname><given-names>H</given-names></name><xref ref-type="aff" rid="au5">5</xref></contrib><contrib contrib-type="author"><name><surname>Kin</surname><given-names>T</given-names></name><xref ref-type="aff" rid="au6">6</xref></contrib><contrib contrib-type="author"><name><surname>Kay</surname><given-names>T W</given-names></name><xref ref-type="aff" rid="au7">7</xref></contrib><contrib contrib-type="author"><name><surname>Wease</surname><given-names>S</given-names></name><xref ref-type="aff" rid="au5">5</xref></contrib><contrib contrib-type="author"><name><surname>Messinger</surname><given-names>S</given-names></name><xref ref-type="aff" rid="au8">8</xref></contrib><contrib contrib-type="author"><name><surname>Ricordi</surname><given-names>C</given-names></name><xref ref-type="aff" rid="au9">9</xref></contrib><contrib contrib-type="author"><name><surname>Alejandro</surname><given-names>R</given-names></name><xref ref-type="aff" rid="au9">9</xref></contrib><contrib contrib-type="author"><name><surname>Markmann</surname><given-names>J</given-names></name><xref ref-type="aff" rid="au10">10</xref></contrib><contrib contrib-type="author"><name><surname>Kerr-Conti</surname><given-names>J</given-names></name><xref ref-type="aff" rid="au11">11</xref></contrib><contrib contrib-type="author"><name><surname>Rickels</surname><given-names>M R</given-names></name><xref ref-type="aff" rid="au12">12</xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>C</given-names></name><xref ref-type="aff" rid="au13">13</xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>X</given-names></name><xref ref-type="aff" rid="au14">14</xref></contrib><contrib contrib-type="author"><name><surname>Witkowski</surname><given-names>P</given-names></name><xref ref-type="aff" rid="au15">15</xref></contrib><contrib contrib-type="author"><name><surname>Posselt</surname><given-names>A</given-names></name><xref ref-type="aff" rid="au16">16</xref></contrib><contrib contrib-type="author"><name><surname>Maffi</surname><given-names>P</given-names></name><xref ref-type="aff" rid="au17">17</xref></contrib><contrib contrib-type="author"><name><surname>Secchi</surname><given-names>A</given-names></name><xref ref-type="aff" rid="au17">17</xref></contrib><contrib contrib-type="author"><name><surname>Berney</surname><given-names>T</given-names></name><xref ref-type="aff" rid="au18">18</xref></contrib><contrib contrib-type="author"><name><surname>O’Connell</surname><given-names>P J</given-names></name><xref ref-type="aff" rid="au19">19</xref></contrib><contrib contrib-type="author"><name><surname>Hering</surname><given-names>B J</given-names></name><xref ref-type="aff" rid="au1">1</xref></contrib><contrib contrib-type="author"><name><surname>Barton</surname><given-names>F B</given-names></name><xref ref-type="aff" rid="au5">5</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><aff id="au1"><label>1</label><institution>Schulze Diabetes Institute, Department of Surgery, University of Minnesota</institution><addr-line>Minneapolis, MN</addr-line></aff><aff id="au2"><label>2</label><institution>Baylor Annette C. and Harold C. Simmons Transplant Institute</institution><addr-line>Dallas, TX</addr-line></aff><aff id="au3"><label>3</label><institution>Research and Development Center, Otsuka Pharmaceutical Factory, Inc.</institution><addr-line>Tokushima, Japan</addr-line></aff><aff id="au4"><label>4</label><institution>Institute for Cellular Transplantation, University of Arizona</institution><addr-line>Tucson, AZ</addr-line></aff><aff id="au5"><label>5</label><institution>The EMMES Corporation</institution><addr-line>Rockville, MD</addr-line></aff><aff id="au6"><label>6</label><institution>Clinical Islet Laboratory, University of Alberta</institution><addr-line>Edmonton, AB</addr-line></aff><aff id="au7"><label>7</label><institution>St. Vincent's Hospital</institution><addr-line>Melbourne, Australia</addr-line></aff><aff id="au8"><label>8</label><institution>Department of Public Health Services, University of Miami</institution><addr-line>Miami, FL</addr-line></aff><aff id="au9"><label>9</label><institution>Diabetes Research Institute, University of Miami</institution><addr-line>Miami, FL</addr-line></aff><aff id="au10"><label>10</label><institution>Department of Surgery, Massachusetts General Hospital</institution><addr-line>Boston, MA</addr-line></aff><aff id="au11"><label>11</label><institution>Lille University Hospital</institution><addr-line>Lille, France</addr-line></aff><aff id="au12"><label>12</label><institution>Department of Medicine, University of Pennsylvania</institution><addr-line>Philadelphia, PA</addr-line></aff><aff id="au13"><label>13</label><institution>Department of Surgery, University of Pennsylvania</institution><addr-line>Philadelphia, PA</addr-line></aff><aff id="au14"><label>14</label><institution>Feinberg School of Medicine, Northwestern University</institution><addr-line>Chicago, IL</addr-line></aff><aff id="au15"><label>15</label><institution>Department of Surgery, University of Chicago</institution><addr-line>Chicago, IL</addr-line></aff><aff id="au16"><label>16</label><institution>Department of Surgery, University of California, San Francisco</institution><addr-line>San Francisco, CA</addr-line></aff><aff id="au17"><label>17</label><institution>Vita-Salute, San Raffaele University</institution><addr-line>Milan, Italy</addr-line></aff><aff id="au18"><label>18</label><institution>Department of Surgery, Geneva University Hospital</institution><addr-line>Geneva, Switzerland</addr-line></aff><aff id="au19"><label>19</label><institution>National Pancreas Transplant Unit, University of Sydney at Westmead Hospital</institution><addr-line>Sydney, Australia</addr-line></aff></contrib-group><author-notes><corresp id="cor1">* <italic>Corresponding authors: Appakalai N. Balamurugan</italic>, <email>isletologist@hotmail.com</email><italic>and Franca B. Barton</italic>, <email>fbarton@emmes.com</email></corresp><corresp id="cor2">† Current address: Islet Cell Laboratory, Cardiovascular Innovation Institute, Department of Surgery, University of Louisville, Louisville, KY
</corresp></author-notes><pub-date pub-type="ppub"><month>11</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>02</day><month>10</month><year>2014</year></pub-date><volume>14</volume><issue>11</issue><fpage>2595</fpage><lpage>2606</lpage><history><date date-type="received"><day>03</day><month>3</month><year>2014</year></date><date date-type="rev-recd"><day>30</day><month>5</month><year>2014</year></date><date date-type="accepted"><day>18</day><month>6</month><year>2014</year></date></history><permissions><copyright-statement>© 2014 The Authors. <italic>American Journal of Transplantation</italic> Published by Wiley Periodicals, Inc. <italic>on behalf of American Society of Transplant Surgeons</italic></copyright-statement><copyright-year>2014</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-nd/3.0/"><license-p>This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.</license-p></license></permissions><abstract><p>The Collaborative Islet Transplant Registry (CITR) collects data on clinical islet isolations and transplants. This retrospective report analyzed 1017 islet isolation procedures performed for 537 recipients of allogeneic clinical islet transplantation in 1999–2010. This study describes changes in donor and islet isolation variables by era and factors associated with quantity and quality of final islet products. Donor body weight and BMI increased significantly over the period (p < 0.001). Islet yield measures have improved with time including islet equivalent (IEQ)/particle ratio and IEQs infused. The average dose of islets infused significantly increased in the era of 2007–2010 when compared to 1999–2002 (445.4 ± 156.8 vs. 421.3 ± 155.4 ×10<sup>3</sup> IEQ; p < 0.05). Islet purity and total number of β cells significantly improved over the study period (p < 0.01 and <0.05, respectively). Otherwise, the quality of clinical islets has remained consistently very high through this period, and differs substantially from nonclinical islets. In multivariate analysis of all recipient, donor and islet factors, and medical management factors, the only islet product characteristic that correlated with clinical outcomes was total IEQs infused. This analysis shows improvements in both quantity and some quality criteria of clinical islets produced over 1999–2010, and these parallel improvements in clinical outcomes over the same period.</p></abstract><kwd-group><kwd>Clinical research/practice</kwd><kwd>diabetes: type 1</kwd><kwd>endocrinology/diabetology</kwd><kwd>health services and outcomes research</kwd><kwd>islet isolation</kwd><kwd>islet transplantation</kwd><kwd>Organ Procurement and Transplantation Network (OPTN)</kwd><kwd>pancreas/simultaneous pancreas-kidney transplantation</kwd><kwd>registry/registry analysis</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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