Succinate Dehydrogenase (SDH)-deficient Renal Carcinoma: A Morphologically Distinct Entity
Identifieur interne : 002083 ( Pmc/Curation ); précédent : 002082; suivant : 002084Succinate Dehydrogenase (SDH)-deficient Renal Carcinoma: A Morphologically Distinct Entity
Auteurs : Anthony J. Gill [Australie] ; Ondrej Hes [République tchèque] ; Thomas Papathomas [Pays-Bas] ; Monika Šedivcová [République tchèque] ; Puay Hoon Tan [Singapour] ; Abbas Agaimy [Allemagne] ; Per Arne Andresen ; Andrew Kedziora ; Adele Clarkson ; Christopher W. Toon [Australie] ; Loretta Sioson [Australie] ; Nicole Watson ; Angela Chou ; Julie Paik ; Roderick J. Clifton-Bligh [Australie] ; Bruce G. Robinson [Australie] ; Diana E. Benn [Australie] ; Kirsten Hills ; Fiona Maclean ; Nicolasine D. Niemeijer [Pays-Bas] ; Ljiljana Vlatkovic [Norvège] ; Arndt Hartmann [Allemagne] ; Eleonora P. M. Corssmit [Pays-Bas] ; Geert J. L. H. Van Leenders [Pays-Bas] ; Christopher Przybycin [États-Unis] ; Jesse K. Mckenney [États-Unis] ; Cristina Magi-Galluzzi [États-Unis] ; Asli Yilmaz [Canada] ; Darryl Yu [Canada] ; Katherine D. Nicoll ; Jim L. Yong ; Mathilde Sibony [France] ; Evgeny Yakirevich [États-Unis] ; Stewart Fleming [Royaume-Uni] ; Chung W. Chow [Australie] ; Markku Miettinen [États-Unis] ; Michal Michal [République tchèque] ; Kiril Trpkov [Canada]Source :
- The American Journal of Surgical Pathology [ 0147-5185 ] ; 2014.
Abstract
Supplemental Digital Content is available in the text.
Url:
DOI: 10.1097/PAS.0000000000000292
PubMed: 25025441
PubMed Central: 4229399
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Per Arne Andresen<affiliation><nlm:aff id="aff8">Department of Pathology, Oslo University Hospital</nlm:aff><wicri:noCountry code="subfield">Oslo University Hospital</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff10">Department of Anatomical Pathology, St Vincents Hospital, Darlinghurst</nlm:aff><wicri:noCountry code="subfield">Darlinghurst</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff11">Cancer Genetics, Kolling Institute of Medical Research, Royal North Shore Hospital</nlm:aff><wicri:noCountry code="subfield">Royal North Shore Hospital</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff11">Cancer Genetics, Kolling Institute of Medical Research, Royal North Shore Hospital</nlm:aff><wicri:noCountry code="subfield">Royal North Shore Hospital</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff11">Cancer Genetics, Kolling Institute of Medical Research, Royal North Shore Hospital</nlm:aff><wicri:noCountry code="subfield">Royal North Shore Hospital</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff12">Pathology Queensland, Gold Coast University Hospital, Qld</nlm:aff><wicri:noCountry code="subfield">Qld</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff13">Douglass Hanly Moir Pathology, North Ryde</nlm:aff><wicri:noCountry code="subfield">North Ryde</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff18">Department of Anatomical Pathology, South Western Area Pathology Service, Liverpool, NSW</nlm:aff><wicri:noCountry code="subfield">NSW</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff18">Department of Anatomical Pathology, South Western Area Pathology Service, Liverpool, NSW</nlm:aff><wicri:noCountry code="subfield">NSW</wicri:noCountry></affiliation>Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Succinate Dehydrogenase (SDH)-deficient Renal Carcinoma: A Morphologically Distinct Entity</title><author><name sortKey="Gill, Anthony J" sort="Gill, Anthony J" uniqKey="Gill A" first="Anthony J." last="Gill">Anthony J. Gill</name><affiliation><nlm:aff id="aff1">Department of Anatomical Pathology</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Cancer Diagnosis and Pathology Research Group</nlm:aff></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3">University of Sydney, Sydney</nlm:aff><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><wicri:orgArea>University of Sydney</wicri:orgArea></affiliation></author><author><name sortKey="Hes, Ondrej" sort="Hes, Ondrej" uniqKey="Hes O" first="Ondrej" last="Hes">Ondrej Hes</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Pathology, Medical Faculty and Charles University, Pilsen, Czech Republic</nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Pathology, Medical Faculty and Charles University, Pilsen</wicri:regionArea></affiliation></author><author><name sortKey="Papathomas, Thomas" sort="Papathomas, Thomas" uniqKey="Papathomas T" first="Thomas" last="Papathomas">Thomas Papathomas</name><affiliation wicri:level="3"><nlm:aff id="aff5">Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Centre, Rotterdam</nlm:aff><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName><wicri:orgArea>Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Centre</wicri:orgArea></affiliation></author><author><name sortKey="Sedivcova, Monika" sort="Sedivcova, Monika" uniqKey="Sedivcova M" first="Monika" last="Šedivcová">Monika Šedivcová</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Pathology, Medical Faculty and Charles University, Pilsen, Czech Republic</nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Pathology, Medical Faculty and Charles University, Pilsen</wicri:regionArea></affiliation></author><author><name sortKey="Tan, Puay Hoon" sort="Tan, Puay Hoon" uniqKey="Tan P" first="Puay Hoon" last="Tan">Puay Hoon Tan</name><affiliation wicri:level="1"><nlm:aff id="aff6">Department of Pathology, Singapore General Hospital, Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Pathology, Singapore General Hospital, Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Agaimy, Abbas" sort="Agaimy, Abbas" uniqKey="Agaimy A" first="Abbas" last="Agaimy">Abbas Agaimy</name><affiliation wicri:level="1"><nlm:aff id="aff7">Institute of Pathology, Friedrich-Alexander-University, Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pathology, Friedrich-Alexander-University, Erlangen</wicri:regionArea></affiliation></author><author><name sortKey="Andresen, Per Arne" sort="Andresen, Per Arne" uniqKey="Andresen P" first="Per Arne" last="Andresen">Per Arne Andresen</name><affiliation><nlm:aff id="aff8">Department of Pathology, Oslo University Hospital</nlm:aff><wicri:noCountry code="subfield">Oslo University Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Kedziora, Andrew" sort="Kedziora, Andrew" uniqKey="Kedziora A" first="Andrew" last="Kedziora">Andrew Kedziora</name><affiliation><nlm:aff id="aff2">Cancer Diagnosis and Pathology Research Group</nlm:aff></affiliation></author><author><name sortKey="Clarkson, Adele" sort="Clarkson, Adele" uniqKey="Clarkson A" first="Adele" last="Clarkson">Adele Clarkson</name><affiliation><nlm:aff id="aff1">Department of Anatomical Pathology</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Cancer Diagnosis and Pathology Research Group</nlm:aff></affiliation></author><author><name sortKey="Toon, Christopher W" sort="Toon, Christopher W" uniqKey="Toon C" first="Christopher W." last="Toon">Christopher W. Toon</name><affiliation><nlm:aff id="aff2">Cancer Diagnosis and Pathology Research Group</nlm:aff></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3">University of Sydney, Sydney</nlm:aff><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><wicri:orgArea>University of Sydney</wicri:orgArea></affiliation><affiliation><nlm:aff id="aff9">Histopath Pathology</nlm:aff></affiliation></author><author><name sortKey="Sioson, Loretta" sort="Sioson, Loretta" uniqKey="Sioson L" first="Loretta" last="Sioson">Loretta Sioson</name><affiliation><nlm:aff id="aff2">Cancer Diagnosis and Pathology Research Group</nlm:aff></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3">University of Sydney, Sydney</nlm:aff><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><wicri:orgArea>University of Sydney</wicri:orgArea></affiliation></author><author><name sortKey="Watson, Nicole" sort="Watson, Nicole" uniqKey="Watson N" first="Nicole" last="Watson">Nicole Watson</name><affiliation><nlm:aff id="aff2">Cancer Diagnosis and Pathology Research Group</nlm:aff></affiliation></author><author><name sortKey="Chou, Angela" sort="Chou, Angela" uniqKey="Chou A" first="Angela" last="Chou">Angela Chou</name><affiliation><nlm:aff id="aff2">Cancer Diagnosis and Pathology Research Group</nlm:aff></affiliation><affiliation><nlm:aff id="aff10">Department of Anatomical Pathology, St Vincents Hospital, Darlinghurst</nlm:aff><wicri:noCountry code="subfield">Darlinghurst</wicri:noCountry></affiliation></author><author><name sortKey="Paik, Julie" sort="Paik, Julie" uniqKey="Paik J" first="Julie" last="Paik">Julie Paik</name><affiliation><nlm:aff id="aff1">Department of Anatomical Pathology</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Cancer Diagnosis and Pathology Research Group</nlm:aff></affiliation></author><author><name sortKey="Clifton Bligh, Roderick J" sort="Clifton Bligh, Roderick J" uniqKey="Clifton Bligh R" first="Roderick J." last="Clifton-Bligh">Roderick J. Clifton-Bligh</name><affiliation wicri:level="3"><nlm:aff id="aff3">University of Sydney, Sydney</nlm:aff><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><wicri:orgArea>University of Sydney</wicri:orgArea></affiliation><affiliation><nlm:aff id="aff11">Cancer Genetics, Kolling Institute of Medical Research, Royal North Shore Hospital</nlm:aff><wicri:noCountry code="subfield">Royal North Shore Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Robinson, Bruce G" sort="Robinson, Bruce G" uniqKey="Robinson B" first="Bruce G." last="Robinson">Bruce G. Robinson</name><affiliation wicri:level="3"><nlm:aff id="aff3">University of Sydney, Sydney</nlm:aff><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><wicri:orgArea>University of Sydney</wicri:orgArea></affiliation><affiliation><nlm:aff id="aff11">Cancer Genetics, Kolling Institute of Medical Research, Royal North Shore Hospital</nlm:aff><wicri:noCountry code="subfield">Royal North Shore Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Benn, Diana E" sort="Benn, Diana E" uniqKey="Benn D" first="Diana E." last="Benn">Diana E. Benn</name><affiliation wicri:level="3"><nlm:aff id="aff3">University of Sydney, Sydney</nlm:aff><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><wicri:orgArea>University of Sydney</wicri:orgArea></affiliation><affiliation><nlm:aff id="aff11">Cancer Genetics, Kolling Institute of Medical Research, Royal North Shore Hospital</nlm:aff><wicri:noCountry code="subfield">Royal North Shore Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Hills, Kirsten" sort="Hills, Kirsten" uniqKey="Hills K" first="Kirsten" last="Hills">Kirsten Hills</name><affiliation><nlm:aff id="aff12">Pathology Queensland, Gold Coast University Hospital, Qld</nlm:aff><wicri:noCountry code="subfield">Qld</wicri:noCountry></affiliation></author><author><name sortKey="Maclean, Fiona" sort="Maclean, Fiona" uniqKey="Maclean F" first="Fiona" last="Maclean">Fiona Maclean</name><affiliation><nlm:aff id="aff13">Douglass Hanly Moir Pathology, North Ryde</nlm:aff><wicri:noCountry code="subfield">North Ryde</wicri:noCountry></affiliation></author><author><name sortKey="Niemeijer, Nicolasine D" sort="Niemeijer, Nicolasine D" uniqKey="Niemeijer N" first="Nicolasine D." last="Niemeijer">Nicolasine D. Niemeijer</name><affiliation wicri:level="1"><nlm:aff id="aff14">Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Endocrinology, Leiden University Medical Center, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Vlatkovic, Ljiljana" sort="Vlatkovic, Ljiljana" uniqKey="Vlatkovic L" first="Ljiljana" last="Vlatkovic">Ljiljana Vlatkovic</name><affiliation wicri:level="1"><nlm:aff id="aff15">Department of Pathology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Pathology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo</wicri:regionArea></affiliation></author><author><name sortKey="Hartmann, Arndt" sort="Hartmann, Arndt" uniqKey="Hartmann A" first="Arndt" last="Hartmann">Arndt Hartmann</name><affiliation wicri:level="1"><nlm:aff id="aff7">Institute of Pathology, Friedrich-Alexander-University, Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pathology, Friedrich-Alexander-University, Erlangen</wicri:regionArea></affiliation></author><author><name sortKey="Corssmit, Eleonora P M" sort="Corssmit, Eleonora P M" uniqKey="Corssmit E" first="Eleonora P. M." last="Corssmit">Eleonora P. M. Corssmit</name><affiliation wicri:level="1"><nlm:aff id="aff14">Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Endocrinology, Leiden University Medical Center, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Van Leenders, Geert J L H" sort="Van Leenders, Geert J L H" uniqKey="Van Leenders G" first="Geert J. L. H." last="Van Leenders">Geert J. L. H. Van Leenders</name><affiliation wicri:level="3"><nlm:aff id="aff5">Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Centre, Rotterdam</nlm:aff><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName><wicri:orgArea>Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Centre</wicri:orgArea></affiliation></author><author><name sortKey="Przybycin, Christopher" sort="Przybycin, Christopher" uniqKey="Przybycin C" first="Christopher" last="Przybycin">Christopher Przybycin</name><affiliation wicri:level="2"><nlm:aff id="aff16">Robert J Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Robert J Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Mckenney, Jesse K" sort="Mckenney, Jesse K" uniqKey="Mckenney J" first="Jesse K." last="Mckenney">Jesse K. Mckenney</name><affiliation wicri:level="2"><nlm:aff id="aff16">Robert J Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Robert J Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Magi Galluzzi, Cristina" sort="Magi Galluzzi, Cristina" uniqKey="Magi Galluzzi C" first="Cristina" last="Magi-Galluzzi">Cristina Magi-Galluzzi</name><affiliation wicri:level="2"><nlm:aff id="aff16">Robert J Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Robert J Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Yilmaz, Asli" sort="Yilmaz, Asli" uniqKey="Yilmaz A" first="Asli" last="Yilmaz">Asli Yilmaz</name><affiliation wicri:level="1"><nlm:aff id="aff17">Department of Pathology and Laboratory Medicine, Calgary Laboratory Services and University of Calgary, Calgary, AB, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, Calgary Laboratory Services and University of Calgary, Calgary, AB</wicri:regionArea></affiliation></author><author><name sortKey="Yu, Darryl" sort="Yu, Darryl" uniqKey="Yu D" first="Darryl" last="Yu">Darryl Yu</name><affiliation wicri:level="1"><nlm:aff id="aff17">Department of Pathology and Laboratory Medicine, Calgary Laboratory Services and University of Calgary, Calgary, AB, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, Calgary Laboratory Services and University of Calgary, Calgary, AB</wicri:regionArea></affiliation></author><author><name sortKey="Nicoll, Katherine D" sort="Nicoll, Katherine D" uniqKey="Nicoll K" first="Katherine D." last="Nicoll">Katherine D. Nicoll</name><affiliation><nlm:aff id="aff18">Department of Anatomical Pathology, South Western Area Pathology Service, Liverpool, NSW</nlm:aff><wicri:noCountry code="subfield">NSW</wicri:noCountry></affiliation></author><author><name sortKey="Yong, Jim L" sort="Yong, Jim L" uniqKey="Yong J" first="Jim L." last="Yong">Jim L. Yong</name><affiliation><nlm:aff id="aff18">Department of Anatomical Pathology, South Western Area Pathology Service, Liverpool, NSW</nlm:aff><wicri:noCountry code="subfield">NSW</wicri:noCountry></affiliation></author><author><name sortKey="Sibony, Mathilde" sort="Sibony, Mathilde" uniqKey="Sibony M" first="Mathilde" last="Sibony">Mathilde Sibony</name><affiliation wicri:level="1"><nlm:aff id="aff19">Department of Pathology, Hopital Cochin Université Paris Descartes, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Pathology, Hopital Cochin Université Paris Descartes, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Yakirevich, Evgeny" sort="Yakirevich, Evgeny" uniqKey="Yakirevich E" first="Evgeny" last="Yakirevich">Evgeny Yakirevich</name><affiliation wicri:level="2"><nlm:aff id="aff20">Department of Pathology, Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Rhode Island</region></placeName><wicri:cityArea>Department of Pathology, Alpert Medical School of Brown University, Rhode Island Hospital, Providence</wicri:cityArea></affiliation></author><author><name sortKey="Fleming, Stewart" sort="Fleming, Stewart" uniqKey="Fleming S" first="Stewart" last="Fleming">Stewart Fleming</name><affiliation wicri:level="1"><nlm:aff id="aff21">Department of Molecular Pathology, University of Dundee, Ninewells Hospital, Dundee, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Molecular Pathology, University of Dundee, Ninewells Hospital, Dundee</wicri:regionArea></affiliation></author><author><name sortKey="Chow, Chung W" sort="Chow, Chung W" uniqKey="Chow C" first="Chung W." last="Chow">Chung W. Chow</name><affiliation wicri:level="1"><nlm:aff id="aff22">Department of Anatomical Pathology, Royal Children’s Hospital, Parkville, Vic., Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Anatomical Pathology, Royal Children’s Hospital, Parkville, Vic.</wicri:regionArea></affiliation></author><author><name sortKey="Miettinen, Markku" sort="Miettinen, Markku" uniqKey="Miettinen M" first="Markku" last="Miettinen">Markku Miettinen</name><affiliation wicri:level="2"><nlm:aff id="aff23">Laboratory of Surgical Pathology, National Cancer Institute, Bethesda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Surgical Pathology, National Cancer Institute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Michal, Michal" sort="Michal, Michal" uniqKey="Michal M" first="Michal" last="Michal">Michal Michal</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Pathology, Medical Faculty and Charles University, Pilsen, Czech Republic</nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Pathology, Medical Faculty and Charles University, Pilsen</wicri:regionArea></affiliation></author><author><name sortKey="Trpkov, Kiril" sort="Trpkov, Kiril" uniqKey="Trpkov K" first="Kiril" last="Trpkov">Kiril Trpkov</name><affiliation wicri:level="1"><nlm:aff id="aff17">Department of Pathology and Laboratory Medicine, Calgary Laboratory Services and University of Calgary, Calgary, AB, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, Calgary Laboratory Services and University of Calgary, Calgary, AB</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25025441</idno><idno type="pmc">4229399</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229399</idno><idno type="RBID">PMC:4229399</idno><idno type="doi">10.1097/PAS.0000000000000292</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002233</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002233</idno><idno type="wicri:Area/Pmc/Curation">002083</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002083</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Succinate Dehydrogenase (SDH)-deficient Renal Carcinoma: A Morphologically Distinct Entity</title><author><name sortKey="Gill, Anthony J" sort="Gill, Anthony J" uniqKey="Gill A" first="Anthony J." last="Gill">Anthony J. Gill</name><affiliation><nlm:aff id="aff1">Department of Anatomical Pathology</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Cancer Diagnosis and Pathology Research Group</nlm:aff></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3">University of Sydney, Sydney</nlm:aff><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><wicri:orgArea>University of Sydney</wicri:orgArea></affiliation></author><author><name sortKey="Hes, Ondrej" sort="Hes, Ondrej" uniqKey="Hes O" first="Ondrej" last="Hes">Ondrej Hes</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Pathology, Medical Faculty and Charles University, Pilsen, Czech Republic</nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Pathology, Medical Faculty and Charles University, Pilsen</wicri:regionArea></affiliation></author><author><name sortKey="Papathomas, Thomas" sort="Papathomas, Thomas" uniqKey="Papathomas T" first="Thomas" last="Papathomas">Thomas Papathomas</name><affiliation wicri:level="3"><nlm:aff id="aff5">Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Centre, Rotterdam</nlm:aff><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName><wicri:orgArea>Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Centre</wicri:orgArea></affiliation></author><author><name sortKey="Sedivcova, Monika" sort="Sedivcova, Monika" uniqKey="Sedivcova M" first="Monika" last="Šedivcová">Monika Šedivcová</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Pathology, Medical Faculty and Charles University, Pilsen, Czech Republic</nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Pathology, Medical Faculty and Charles University, Pilsen</wicri:regionArea></affiliation></author><author><name sortKey="Tan, Puay Hoon" sort="Tan, Puay Hoon" uniqKey="Tan P" first="Puay Hoon" last="Tan">Puay Hoon Tan</name><affiliation wicri:level="1"><nlm:aff id="aff6">Department of Pathology, Singapore General Hospital, Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Pathology, Singapore General Hospital, Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Agaimy, Abbas" sort="Agaimy, Abbas" uniqKey="Agaimy A" first="Abbas" last="Agaimy">Abbas Agaimy</name><affiliation wicri:level="1"><nlm:aff id="aff7">Institute of Pathology, Friedrich-Alexander-University, Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pathology, Friedrich-Alexander-University, Erlangen</wicri:regionArea></affiliation></author><author><name sortKey="Andresen, Per Arne" sort="Andresen, Per Arne" uniqKey="Andresen P" first="Per Arne" last="Andresen">Per Arne Andresen</name><affiliation><nlm:aff id="aff8">Department of Pathology, Oslo University Hospital</nlm:aff><wicri:noCountry code="subfield">Oslo University Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Kedziora, Andrew" sort="Kedziora, Andrew" uniqKey="Kedziora A" first="Andrew" last="Kedziora">Andrew Kedziora</name><affiliation><nlm:aff id="aff2">Cancer Diagnosis and Pathology Research Group</nlm:aff></affiliation></author><author><name sortKey="Clarkson, Adele" sort="Clarkson, Adele" uniqKey="Clarkson A" first="Adele" last="Clarkson">Adele Clarkson</name><affiliation><nlm:aff id="aff1">Department of Anatomical Pathology</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Cancer Diagnosis and Pathology Research Group</nlm:aff></affiliation></author><author><name sortKey="Toon, Christopher W" sort="Toon, Christopher W" uniqKey="Toon C" first="Christopher W." last="Toon">Christopher W. Toon</name><affiliation><nlm:aff id="aff2">Cancer Diagnosis and Pathology Research Group</nlm:aff></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3">University of Sydney, Sydney</nlm:aff><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><wicri:orgArea>University of Sydney</wicri:orgArea></affiliation><affiliation><nlm:aff id="aff9">Histopath Pathology</nlm:aff></affiliation></author><author><name sortKey="Sioson, Loretta" sort="Sioson, Loretta" uniqKey="Sioson L" first="Loretta" last="Sioson">Loretta Sioson</name><affiliation><nlm:aff id="aff2">Cancer Diagnosis and Pathology Research Group</nlm:aff></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3">University of Sydney, Sydney</nlm:aff><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><wicri:orgArea>University of Sydney</wicri:orgArea></affiliation></author><author><name sortKey="Watson, Nicole" sort="Watson, Nicole" uniqKey="Watson N" first="Nicole" last="Watson">Nicole Watson</name><affiliation><nlm:aff id="aff2">Cancer Diagnosis and Pathology Research Group</nlm:aff></affiliation></author><author><name sortKey="Chou, Angela" sort="Chou, Angela" uniqKey="Chou A" first="Angela" last="Chou">Angela Chou</name><affiliation><nlm:aff id="aff2">Cancer Diagnosis and Pathology Research Group</nlm:aff></affiliation><affiliation><nlm:aff id="aff10">Department of Anatomical Pathology, St Vincents Hospital, Darlinghurst</nlm:aff><wicri:noCountry code="subfield">Darlinghurst</wicri:noCountry></affiliation></author><author><name sortKey="Paik, Julie" sort="Paik, Julie" uniqKey="Paik J" first="Julie" last="Paik">Julie Paik</name><affiliation><nlm:aff id="aff1">Department of Anatomical Pathology</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Cancer Diagnosis and Pathology Research Group</nlm:aff></affiliation></author><author><name sortKey="Clifton Bligh, Roderick J" sort="Clifton Bligh, Roderick J" uniqKey="Clifton Bligh R" first="Roderick J." last="Clifton-Bligh">Roderick J. Clifton-Bligh</name><affiliation wicri:level="3"><nlm:aff id="aff3">University of Sydney, Sydney</nlm:aff><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><wicri:orgArea>University of Sydney</wicri:orgArea></affiliation><affiliation><nlm:aff id="aff11">Cancer Genetics, Kolling Institute of Medical Research, Royal North Shore Hospital</nlm:aff><wicri:noCountry code="subfield">Royal North Shore Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Robinson, Bruce G" sort="Robinson, Bruce G" uniqKey="Robinson B" first="Bruce G." last="Robinson">Bruce G. Robinson</name><affiliation wicri:level="3"><nlm:aff id="aff3">University of Sydney, Sydney</nlm:aff><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><wicri:orgArea>University of Sydney</wicri:orgArea></affiliation><affiliation><nlm:aff id="aff11">Cancer Genetics, Kolling Institute of Medical Research, Royal North Shore Hospital</nlm:aff><wicri:noCountry code="subfield">Royal North Shore Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Benn, Diana E" sort="Benn, Diana E" uniqKey="Benn D" first="Diana E." last="Benn">Diana E. Benn</name><affiliation wicri:level="3"><nlm:aff id="aff3">University of Sydney, Sydney</nlm:aff><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><wicri:orgArea>University of Sydney</wicri:orgArea></affiliation><affiliation><nlm:aff id="aff11">Cancer Genetics, Kolling Institute of Medical Research, Royal North Shore Hospital</nlm:aff><wicri:noCountry code="subfield">Royal North Shore Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Hills, Kirsten" sort="Hills, Kirsten" uniqKey="Hills K" first="Kirsten" last="Hills">Kirsten Hills</name><affiliation><nlm:aff id="aff12">Pathology Queensland, Gold Coast University Hospital, Qld</nlm:aff><wicri:noCountry code="subfield">Qld</wicri:noCountry></affiliation></author><author><name sortKey="Maclean, Fiona" sort="Maclean, Fiona" uniqKey="Maclean F" first="Fiona" last="Maclean">Fiona Maclean</name><affiliation><nlm:aff id="aff13">Douglass Hanly Moir Pathology, North Ryde</nlm:aff><wicri:noCountry code="subfield">North Ryde</wicri:noCountry></affiliation></author><author><name sortKey="Niemeijer, Nicolasine D" sort="Niemeijer, Nicolasine D" uniqKey="Niemeijer N" first="Nicolasine D." last="Niemeijer">Nicolasine D. Niemeijer</name><affiliation wicri:level="1"><nlm:aff id="aff14">Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Endocrinology, Leiden University Medical Center, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Vlatkovic, Ljiljana" sort="Vlatkovic, Ljiljana" uniqKey="Vlatkovic L" first="Ljiljana" last="Vlatkovic">Ljiljana Vlatkovic</name><affiliation wicri:level="1"><nlm:aff id="aff15">Department of Pathology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Pathology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo</wicri:regionArea></affiliation></author><author><name sortKey="Hartmann, Arndt" sort="Hartmann, Arndt" uniqKey="Hartmann A" first="Arndt" last="Hartmann">Arndt Hartmann</name><affiliation wicri:level="1"><nlm:aff id="aff7">Institute of Pathology, Friedrich-Alexander-University, Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pathology, Friedrich-Alexander-University, Erlangen</wicri:regionArea></affiliation></author><author><name sortKey="Corssmit, Eleonora P M" sort="Corssmit, Eleonora P M" uniqKey="Corssmit E" first="Eleonora P. M." last="Corssmit">Eleonora P. M. Corssmit</name><affiliation wicri:level="1"><nlm:aff id="aff14">Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Endocrinology, Leiden University Medical Center, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Van Leenders, Geert J L H" sort="Van Leenders, Geert J L H" uniqKey="Van Leenders G" first="Geert J. L. H." last="Van Leenders">Geert J. L. H. Van Leenders</name><affiliation wicri:level="3"><nlm:aff id="aff5">Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Centre, Rotterdam</nlm:aff><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName><wicri:orgArea>Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Centre</wicri:orgArea></affiliation></author><author><name sortKey="Przybycin, Christopher" sort="Przybycin, Christopher" uniqKey="Przybycin C" first="Christopher" last="Przybycin">Christopher Przybycin</name><affiliation wicri:level="2"><nlm:aff id="aff16">Robert J Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Robert J Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Mckenney, Jesse K" sort="Mckenney, Jesse K" uniqKey="Mckenney J" first="Jesse K." last="Mckenney">Jesse K. Mckenney</name><affiliation wicri:level="2"><nlm:aff id="aff16">Robert J Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Robert J Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Magi Galluzzi, Cristina" sort="Magi Galluzzi, Cristina" uniqKey="Magi Galluzzi C" first="Cristina" last="Magi-Galluzzi">Cristina Magi-Galluzzi</name><affiliation wicri:level="2"><nlm:aff id="aff16">Robert J Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Robert J Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Yilmaz, Asli" sort="Yilmaz, Asli" uniqKey="Yilmaz A" first="Asli" last="Yilmaz">Asli Yilmaz</name><affiliation wicri:level="1"><nlm:aff id="aff17">Department of Pathology and Laboratory Medicine, Calgary Laboratory Services and University of Calgary, Calgary, AB, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, Calgary Laboratory Services and University of Calgary, Calgary, AB</wicri:regionArea></affiliation></author><author><name sortKey="Yu, Darryl" sort="Yu, Darryl" uniqKey="Yu D" first="Darryl" last="Yu">Darryl Yu</name><affiliation wicri:level="1"><nlm:aff id="aff17">Department of Pathology and Laboratory Medicine, Calgary Laboratory Services and University of Calgary, Calgary, AB, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, Calgary Laboratory Services and University of Calgary, Calgary, AB</wicri:regionArea></affiliation></author><author><name sortKey="Nicoll, Katherine D" sort="Nicoll, Katherine D" uniqKey="Nicoll K" first="Katherine D." last="Nicoll">Katherine D. Nicoll</name><affiliation><nlm:aff id="aff18">Department of Anatomical Pathology, South Western Area Pathology Service, Liverpool, NSW</nlm:aff><wicri:noCountry code="subfield">NSW</wicri:noCountry></affiliation></author><author><name sortKey="Yong, Jim L" sort="Yong, Jim L" uniqKey="Yong J" first="Jim L." last="Yong">Jim L. Yong</name><affiliation><nlm:aff id="aff18">Department of Anatomical Pathology, South Western Area Pathology Service, Liverpool, NSW</nlm:aff><wicri:noCountry code="subfield">NSW</wicri:noCountry></affiliation></author><author><name sortKey="Sibony, Mathilde" sort="Sibony, Mathilde" uniqKey="Sibony M" first="Mathilde" last="Sibony">Mathilde Sibony</name><affiliation wicri:level="1"><nlm:aff id="aff19">Department of Pathology, Hopital Cochin Université Paris Descartes, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Pathology, Hopital Cochin Université Paris Descartes, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Yakirevich, Evgeny" sort="Yakirevich, Evgeny" uniqKey="Yakirevich E" first="Evgeny" last="Yakirevich">Evgeny Yakirevich</name><affiliation wicri:level="2"><nlm:aff id="aff20">Department of Pathology, Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Rhode Island</region></placeName><wicri:cityArea>Department of Pathology, Alpert Medical School of Brown University, Rhode Island Hospital, Providence</wicri:cityArea></affiliation></author><author><name sortKey="Fleming, Stewart" sort="Fleming, Stewart" uniqKey="Fleming S" first="Stewart" last="Fleming">Stewart Fleming</name><affiliation wicri:level="1"><nlm:aff id="aff21">Department of Molecular Pathology, University of Dundee, Ninewells Hospital, Dundee, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Molecular Pathology, University of Dundee, Ninewells Hospital, Dundee</wicri:regionArea></affiliation></author><author><name sortKey="Chow, Chung W" sort="Chow, Chung W" uniqKey="Chow C" first="Chung W." last="Chow">Chung W. Chow</name><affiliation wicri:level="1"><nlm:aff id="aff22">Department of Anatomical Pathology, Royal Children’s Hospital, Parkville, Vic., Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Anatomical Pathology, Royal Children’s Hospital, Parkville, Vic.</wicri:regionArea></affiliation></author><author><name sortKey="Miettinen, Markku" sort="Miettinen, Markku" uniqKey="Miettinen M" first="Markku" last="Miettinen">Markku Miettinen</name><affiliation wicri:level="2"><nlm:aff id="aff23">Laboratory of Surgical Pathology, National Cancer Institute, Bethesda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Surgical Pathology, National Cancer Institute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Michal, Michal" sort="Michal, Michal" uniqKey="Michal M" first="Michal" last="Michal">Michal Michal</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Pathology, Medical Faculty and Charles University, Pilsen, Czech Republic</nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Pathology, Medical Faculty and Charles University, Pilsen</wicri:regionArea></affiliation></author><author><name sortKey="Trpkov, Kiril" sort="Trpkov, Kiril" uniqKey="Trpkov K" first="Kiril" last="Trpkov">Kiril Trpkov</name><affiliation wicri:level="1"><nlm:aff id="aff17">Department of Pathology and Laboratory Medicine, Calgary Laboratory Services and University of Calgary, Calgary, AB, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, Calgary Laboratory Services and University of Calgary, Calgary, AB</wicri:regionArea></affiliation></author></analytic><series><title level="j">The American Journal of Surgical Pathology</title><idno type="ISSN">0147-5185</idno><idno type="eISSN">1532-0979</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Supplemental Digital Content is available in the text.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Gill, Aj" uniqKey="Gill A">AJ Gill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fishbein, L" uniqKey="Fishbein L">L Fishbein</name></author><author><name sortKey="Nathanson, Kl" uniqKey="Nathanson K">KL Nathanson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gill, Aj" uniqKey="Gill A">AJ Gill</name></author><author><name sortKey="Chou, A" uniqKey="Chou A">A Chou</name></author><author><name sortKey="Vilain, R" uniqKey="Vilain R">R Vilain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gill, 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Am J Surg Pathol</journal-id><journal-id journal-id-type="iso-abbrev">Am. J. Surg. Pathol</journal-id><journal-id journal-id-type="publisher-id">PAS</journal-id><journal-title-group><journal-title>The American Journal of Surgical Pathology</journal-title></journal-title-group><issn pub-type="ppub">0147-5185</issn><issn pub-type="epub">1532-0979</issn><publisher><publisher-name>Raven Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25025441</article-id><article-id pub-id-type="pmc">4229399</article-id><article-id pub-id-type="doi">10.1097/PAS.0000000000000292</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Articles</subject></subj-group></article-categories><title-group><article-title>Succinate Dehydrogenase (SDH)-deficient Renal Carcinoma: A Morphologically Distinct Entity</article-title><subtitle>A Clinicopathologic Series of 36 Tumors From 27 Patients</subtitle></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Gill</surname><given-names>Anthony J.</given-names></name><degrees>MD, FRCPA</degrees><xref ref-type="aff" rid="aff1">*</xref><xref ref-type="aff" rid="aff2">†</xref><xref ref-type="aff" rid="aff3">‡</xref></contrib><contrib contrib-type="author"><name><surname>Hes</surname><given-names>Ondrej</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff4">§</xref></contrib><contrib contrib-type="author"><name><surname>Papathomas</surname><given-names>Thomas</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff5">∥</xref></contrib><contrib contrib-type="author"><name><surname>Šedivcová</surname><given-names>Monika</given-names></name><degrees>MSc</degrees><xref ref-type="aff" rid="aff4">§</xref></contrib><contrib contrib-type="author"><name><surname>Tan</surname><given-names>Puay Hoon</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff6">¶</xref></contrib><contrib contrib-type="author"><name><surname>Agaimy</surname><given-names>Abbas</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff7">#</xref></contrib><contrib contrib-type="author"><name><surname>Andresen</surname><given-names>Per Arne</given-names></name><degrees>MSc</degrees><xref ref-type="aff" rid="aff8">**</xref></contrib><contrib contrib-type="author"><name><surname>Kedziora</surname><given-names>Andrew</given-names></name><degrees>FRCPA</degrees><xref ref-type="aff" rid="aff2">†</xref></contrib><contrib contrib-type="author"><name><surname>Clarkson</surname><given-names>Adele</given-names></name><degrees>BSc</degrees><xref ref-type="aff" rid="aff1">*</xref><xref ref-type="aff" rid="aff2">†</xref></contrib><contrib contrib-type="author"><name><surname>Toon</surname><given-names>Christopher W.</given-names></name><degrees>FRCPA</degrees><xref ref-type="aff" rid="aff2">†</xref><xref ref-type="aff" rid="aff3">‡</xref><xref ref-type="aff" rid="aff9">††</xref></contrib><contrib contrib-type="author"><name><surname>Sioson</surname><given-names>Loretta</given-names></name><degrees>BSc</degrees><xref ref-type="aff" rid="aff2">†</xref><xref ref-type="aff" rid="aff3">‡</xref></contrib><contrib contrib-type="author"><name><surname>Watson</surname><given-names>Nicole</given-names></name><xref ref-type="aff" rid="aff2">†</xref></contrib><contrib contrib-type="author"><name><surname>Chou</surname><given-names>Angela</given-names></name><degrees>FRCPA</degrees><xref ref-type="aff" rid="aff2">†</xref><xref ref-type="aff" rid="aff10">‡‡</xref></contrib><contrib contrib-type="author"><name><surname>Paik</surname><given-names>Julie</given-names></name><degrees>MBBS</degrees><xref ref-type="aff" rid="aff1">*</xref><xref ref-type="aff" rid="aff2">†</xref></contrib><contrib contrib-type="author"><name><surname>Clifton-Bligh</surname><given-names>Roderick J.</given-names></name><degrees>PhD, FRACP</degrees><xref ref-type="aff" rid="aff3">‡</xref><xref ref-type="aff" rid="aff11">§§</xref></contrib><contrib contrib-type="author"><name><surname>Robinson</surname><given-names>Bruce G.</given-names></name><degrees>MD, FRCPA</degrees><xref ref-type="aff" rid="aff3">‡</xref><xref ref-type="aff" rid="aff11">§§</xref></contrib><contrib contrib-type="author"><name><surname>Benn</surname><given-names>Diana E.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff3">‡</xref><xref ref-type="aff" rid="aff11">§§</xref></contrib><contrib contrib-type="author"><name><surname>Hills</surname><given-names>Kirsten</given-names></name><degrees>FRCPA</degrees><xref ref-type="aff" rid="aff12">∥∥</xref></contrib><contrib contrib-type="author"><name><surname>Maclean</surname><given-names>Fiona</given-names></name><degrees>FRCPA</degrees><xref ref-type="aff" rid="aff13">¶¶</xref></contrib><contrib contrib-type="author"><name><surname>Niemeijer</surname><given-names>Nicolasine D.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff14">##</xref></contrib><contrib contrib-type="author"><name><surname>Vlatkovic</surname><given-names>Ljiljana</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff15">***</xref></contrib><contrib contrib-type="author"><name><surname>Hartmann</surname><given-names>Arndt</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff7">#</xref></contrib><contrib contrib-type="author"><name><surname>Corssmit</surname><given-names>Eleonora P.M.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff14">##</xref></contrib><contrib contrib-type="author"><name><surname>van Leenders</surname><given-names>Geert J.L.H.</given-names></name><degrees>MD,PhD</degrees><xref ref-type="aff" rid="aff5">∥</xref></contrib><contrib contrib-type="author"><name><surname>Przybycin</surname><given-names>Christopher</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff16">†††</xref></contrib><contrib contrib-type="author"><name><surname>McKenney</surname><given-names>Jesse K.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff16">†††</xref></contrib><contrib contrib-type="author"><name><surname>Magi-Galluzzi</surname><given-names>Cristina</given-names></name><degrees>MD,PhD</degrees><xref ref-type="aff" rid="aff16">†††</xref></contrib><contrib contrib-type="author"><name><surname>Yilmaz</surname><given-names>Asli</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff17">‡‡‡</xref></contrib><contrib contrib-type="author"><name><surname>Yu</surname><given-names>Darryl</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff17">‡‡‡</xref></contrib><contrib contrib-type="author"><name><surname>Nicoll</surname><given-names>Katherine D.</given-names></name><degrees>FRCPA</degrees><xref ref-type="aff" rid="aff18">§§§</xref></contrib><contrib contrib-type="author"><name><surname>Yong</surname><given-names>Jim L.</given-names></name><degrees>FRCPA</degrees><xref ref-type="aff" rid="aff18">§§§</xref></contrib><contrib contrib-type="author"><name><surname>Sibony</surname><given-names>Mathilde</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="aff19">∥∥∥</xref></contrib><contrib contrib-type="author"><name><surname>Yakirevich</surname><given-names>Evgeny</given-names></name><degrees>MD, DSc</degrees><xref ref-type="aff" rid="aff20">¶¶¶</xref></contrib><contrib contrib-type="author"><name><surname>Fleming</surname><given-names>Stewart</given-names></name><degrees>MD, FRCPATH</degrees><xref ref-type="aff" rid="aff21">###</xref></contrib><contrib contrib-type="author"><name><surname>Chow</surname><given-names>Chung W.</given-names></name><degrees>FRCPA</degrees><xref ref-type="aff" rid="aff22">****</xref></contrib><contrib contrib-type="author"><name><surname>Miettinen</surname><given-names>Markku</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff23">††††</xref></contrib><contrib contrib-type="author"><name><surname>Michal</surname><given-names>Michal</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff4">§</xref></contrib><contrib contrib-type="author"><name><surname>Trpkov</surname><given-names>Kiril</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff17">‡‡‡</xref></contrib></contrib-group><aff id="aff1"><label>*</label>Department of Anatomical Pathology</aff><aff id="aff2"><label>†</label>Cancer Diagnosis and Pathology Research Group</aff><aff id="aff11"><label>§§</label>Cancer Genetics, Kolling Institute of Medical Research, Royal North Shore Hospital</aff><aff id="aff3"><label>‡</label>University of Sydney, Sydney</aff><aff id="aff9"><label>††</label>Histopath Pathology</aff><aff id="aff13"><label>¶¶</label>Douglass Hanly Moir Pathology, North Ryde</aff><aff id="aff10"><label>‡‡</label>Department of Anatomical Pathology, St Vincents Hospital, Darlinghurst</aff><aff id="aff18"><label>§§§</label>Department of Anatomical Pathology, South Western Area Pathology Service, Liverpool, NSW</aff><aff id="aff12"><label>∥∥</label>Pathology Queensland, Gold Coast University Hospital, Qld</aff><aff id="aff22"><label>****</label>Department of Anatomical Pathology, Royal Children’s Hospital, Parkville, Vic., Australia</aff><aff id="aff4"><label>§</label>Department of Pathology, Medical Faculty and Charles University, Pilsen, Czech Republic</aff><aff id="aff5"><label>∥</label>Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Centre, Rotterdam</aff><aff id="aff14"><label>##</label>Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands</aff><aff id="aff6"><label>¶</label>Department of Pathology, Singapore General Hospital, Singapore, Singapore</aff><aff id="aff7"><label>#</label>Institute of Pathology, Friedrich-Alexander-University, Erlangen, Germany</aff><aff id="aff8"><label>**</label>Department of Pathology, Oslo University Hospital</aff><aff id="aff15"><label>***</label>Department of Pathology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway</aff><aff id="aff16"><label>†††</label>Robert J Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH</aff><aff id="aff20"><label>¶¶¶</label>Department of Pathology, Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI</aff><aff id="aff23"><label>††††</label>Laboratory of Surgical Pathology, National Cancer Institute, Bethesda, MD</aff><aff id="aff17"><label>‡‡‡</label>Department of Pathology and Laboratory Medicine, Calgary Laboratory Services and University of Calgary, Calgary, AB, Canada</aff><aff id="aff19"><label>∥∥∥</label>Department of Pathology, Hopital Cochin Université Paris Descartes, Paris, France</aff><aff id="aff21"><label>###</label>Department of Molecular Pathology, University of Dundee, Ninewells Hospital, Dundee, UK</aff><author-notes><corresp>Correspondence: Anthony J. Gill, MD, FRCPA, Department of Anatomical Pathology, Royal North Shore Hospital, Pacific Highway St Leonards, NSW 2065, Australia (e-mail: <email>affgill@med.usyd.edu.au</email>).</corresp></author-notes><pub-date pub-type="ppub"><month>12</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>14</day><month>11</month><year>2014</year></pub-date><volume>38</volume><issue>12</issue><fpage>1588</fpage><lpage>1602</lpage><permissions><copyright-statement>Copyright © 2014 by Lippincott Williams & Wilkins</copyright-statement><copyright-year>2014</copyright-year><license><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivitives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc-nd/3.0">http://creativecommons.org/licenses/by-nc-nd/3.0</ext-link>.</license-p></license></permissions><self-uri xlink:type="simple" xlink:href="pas-38-1588.pdf"></self-uri><abstract abstract-type="toc"><p>Supplemental Digital Content is available in the text.</p></abstract><abstract><p>Succinate dehydrogenase (SDH)-deficient renal carcinoma has been accepted as a provisional entity in the 2013 International Society of Urological Pathology Vancouver Classification. To further define its morphologic and clinical features, we studied a multi-institutional cohort of 36 SDH-deficient renal carcinomas from 27 patients, including 21 previously unreported cases. We estimate that 0.05% to 0.2% of all renal carcinomas are SDH deficient. Mean patient age at presentation was 37 years (range, 14 to 76 y), with a slight male predominance (M:F=1.7:1). Bilateral tumors were observed in 26% of patients. Thirty-four (94%) tumors demonstrated the previously reported morphology at least focally, which included: solid or focally cystic growth, uniform cytology with eosinophilic flocculent cytoplasm, intracytoplasmic vacuolations and inclusions, and round to oval low-grade nuclei. All 17 patients who underwent genetic testing for mutation in the <italic>SDH</italic> subunits demonstrated germline mutations (16 in <italic>SDHB</italic> and 1 in <italic>SDHC</italic>). Nine of 27 (33%) patients developed metastatic disease, 2 of them after prolonged follow-up (5.5 and 30 y). Seven of 10 patients (70%) with high-grade nuclei metastasized as did all 4 patients with coagulative necrosis. Two of 17 (12%) patients with low-grade nuclei metastasized, and both had unbiopsied contralateral tumors, which may have been the origin of the metastatic disease. In conclusion, SDH-deficient renal carcinoma is a rare and unique type of renal carcinoma, exhibiting stereotypical morphologic features in the great majority of cases and showing a strong relationship with <italic>SDH</italic> germline mutation. Although this tumor may undergo dedifferentiation and metastasize, sometimes after a prolonged delay, metastatic disease is rare in the absence of high-grade nuclear atypia or coagulative necrosis.</p></abstract><kwd-group><title>Key Words:</title><kwd>SDHB</kwd><kwd>SDHA</kwd><kwd>succinate dehydrogenase</kwd><kwd>renal carcinoma</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>SDC</meta-name><meta-value>T</meta-value></custom-meta><custom-meta><meta-name>OPEN-ACCESS</meta-name><meta-value>TRUE</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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