Effects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals12345
Identifieur interne : 002079 ( Pmc/Curation ); précédent : 002078; suivant : 002080Effects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals12345
Auteurs : Robert Clarke ; Derrick Bennett ; Sarah Parish ; Sarah Lewington ; Murray Skeaff ; Simone Jpm Eussen ; Catharina Lewerin ; David J. Stott ; Jane Armitage ; Graeme J. Hankey ; Eva Lonn ; J David Spence ; Pilar Galan ; Lisette C. De Groot ; Jim Halsey ; Alan D. Dangour ; Rory Collins ; Francine GrodsteinSource :
- The American Journal of Clinical Nutrition [ 0002-9165 ] ; 2014.
Abstract
Url:
DOI: 10.3945/ajcn.113.076349
PubMed: 24965307
PubMed Central: 4095663
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals<xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="author-notes" rid="fn1"><sup>2</sup></xref><xref ref-type="author-notes" rid="fn2"><sup>3</sup></xref><xref ref-type="author-notes" rid="fn3"><sup>4</sup></xref><xref ref-type="corresp" rid="cor1"><sup>5</sup></xref></title><author><name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name></author><author><name sortKey="Bennett, Derrick" sort="Bennett, Derrick" uniqKey="Bennett D" first="Derrick" last="Bennett">Derrick Bennett</name></author><author><name sortKey="Parish, Sarah" sort="Parish, Sarah" uniqKey="Parish S" first="Sarah" last="Parish">Sarah Parish</name></author><author><name sortKey="Lewington, Sarah" sort="Lewington, Sarah" uniqKey="Lewington S" first="Sarah" last="Lewington">Sarah Lewington</name></author><author><name sortKey="Skeaff, Murray" sort="Skeaff, Murray" uniqKey="Skeaff M" first="Murray" last="Skeaff">Murray Skeaff</name></author><author><name sortKey="Eussen, Simone Jpm" sort="Eussen, Simone Jpm" uniqKey="Eussen S" first="Simone Jpm" last="Eussen">Simone Jpm Eussen</name></author><author><name sortKey="Lewerin, Catharina" sort="Lewerin, Catharina" uniqKey="Lewerin C" first="Catharina" last="Lewerin">Catharina Lewerin</name></author><author><name sortKey="Stott, David J" sort="Stott, David J" uniqKey="Stott D" first="David J" last="Stott">David J. Stott</name></author><author><name sortKey="Armitage, Jane" sort="Armitage, Jane" uniqKey="Armitage J" first="Jane" last="Armitage">Jane Armitage</name></author><author><name sortKey="Hankey, Graeme J" sort="Hankey, Graeme J" uniqKey="Hankey G" first="Graeme J" last="Hankey">Graeme J. Hankey</name></author><author><name sortKey="Lonn, Eva" sort="Lonn, Eva" uniqKey="Lonn E" first="Eva" last="Lonn">Eva Lonn</name></author><author><name sortKey="Spence, J David" sort="Spence, J David" uniqKey="Spence J" first="J David" last="Spence">J David Spence</name></author><author><name sortKey="Galan, Pilar" sort="Galan, Pilar" uniqKey="Galan P" first="Pilar" last="Galan">Pilar Galan</name></author><author><name sortKey="De Groot, Lisette C" sort="De Groot, Lisette C" uniqKey="De Groot L" first="Lisette C" last="De Groot">Lisette C. De Groot</name></author><author><name sortKey="Halsey, Jim" sort="Halsey, Jim" uniqKey="Halsey J" first="Jim" last="Halsey">Jim Halsey</name></author><author><name sortKey="Dangour, Alan D" sort="Dangour, Alan D" uniqKey="Dangour A" first="Alan D" last="Dangour">Alan D. Dangour</name></author><author><name sortKey="Collins, Rory" sort="Collins, Rory" uniqKey="Collins R" first="Rory" last="Collins">Rory Collins</name></author><author><name sortKey="Grodstein, Francine" sort="Grodstein, Francine" uniqKey="Grodstein F" first="Francine" last="Grodstein">Francine Grodstein</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24965307</idno><idno type="pmc">4095663</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4095663</idno><idno type="RBID">PMC:4095663</idno><idno type="doi">10.3945/ajcn.113.076349</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002229</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002229</idno><idno type="wicri:Area/Pmc/Curation">002079</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002079</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals<xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="author-notes" rid="fn1"><sup>2</sup></xref><xref ref-type="author-notes" rid="fn2"><sup>3</sup></xref><xref ref-type="author-notes" rid="fn3"><sup>4</sup></xref><xref ref-type="corresp" rid="cor1"><sup>5</sup></xref></title><author><name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name></author><author><name sortKey="Bennett, Derrick" sort="Bennett, Derrick" uniqKey="Bennett D" first="Derrick" last="Bennett">Derrick Bennett</name></author><author><name sortKey="Parish, Sarah" sort="Parish, Sarah" uniqKey="Parish S" first="Sarah" last="Parish">Sarah Parish</name></author><author><name sortKey="Lewington, Sarah" sort="Lewington, Sarah" uniqKey="Lewington S" first="Sarah" last="Lewington">Sarah Lewington</name></author><author><name sortKey="Skeaff, Murray" sort="Skeaff, Murray" uniqKey="Skeaff M" first="Murray" last="Skeaff">Murray Skeaff</name></author><author><name sortKey="Eussen, Simone Jpm" sort="Eussen, Simone Jpm" uniqKey="Eussen S" first="Simone Jpm" last="Eussen">Simone Jpm Eussen</name></author><author><name sortKey="Lewerin, Catharina" sort="Lewerin, Catharina" uniqKey="Lewerin C" first="Catharina" last="Lewerin">Catharina Lewerin</name></author><author><name sortKey="Stott, David J" sort="Stott, David J" uniqKey="Stott D" first="David J" last="Stott">David J. Stott</name></author><author><name sortKey="Armitage, Jane" sort="Armitage, Jane" uniqKey="Armitage J" first="Jane" last="Armitage">Jane Armitage</name></author><author><name sortKey="Hankey, Graeme J" sort="Hankey, Graeme J" uniqKey="Hankey G" first="Graeme J" last="Hankey">Graeme J. Hankey</name></author><author><name sortKey="Lonn, Eva" sort="Lonn, Eva" uniqKey="Lonn E" first="Eva" last="Lonn">Eva Lonn</name></author><author><name sortKey="Spence, J David" sort="Spence, J David" uniqKey="Spence J" first="J David" last="Spence">J David Spence</name></author><author><name sortKey="Galan, Pilar" sort="Galan, Pilar" uniqKey="Galan P" first="Pilar" last="Galan">Pilar Galan</name></author><author><name sortKey="De Groot, Lisette C" sort="De Groot, Lisette C" uniqKey="De Groot L" first="Lisette C" last="De Groot">Lisette C. De Groot</name></author><author><name sortKey="Halsey, Jim" sort="Halsey, Jim" uniqKey="Halsey J" first="Jim" last="Halsey">Jim Halsey</name></author><author><name sortKey="Dangour, Alan D" sort="Dangour, Alan D" uniqKey="Dangour A" first="Alan D" last="Dangour">Alan D. Dangour</name></author><author><name sortKey="Collins, Rory" sort="Collins, Rory" uniqKey="Collins R" first="Rory" last="Collins">Rory Collins</name></author><author><name sortKey="Grodstein, Francine" sort="Grodstein, Francine" uniqKey="Grodstein F" first="Francine" last="Grodstein">Francine Grodstein</name></author></analytic><series><title level="j">The American Journal of Clinical Nutrition</title><idno type="ISSN">0002-9165</idno><idno type="eISSN">1938-3207</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Background:</bold> Elevated plasma homocysteine is a risk factor for Alzheimer disease, but the relevance of homocysteine lowering to slow the rate of cognitive aging is uncertain.</p><p><bold>Objective:</bold> The aim was to assess the effects of treatment with B vitamins compared with placebo, when administered for several years, on composite domains of cognitive function, global cognitive function, and cognitive aging.</p><p><bold>Design:</bold> A meta-analysis was conducted by using data combined from 11 large trials in 22,000 participants. Domain-based <italic>z</italic> scores (for memory, speed, and executive function and a domain-composite score for global cognitive function) were available before and after treatment (mean duration: 2.3 y) in the 4 cognitive-domain trials (1340 individuals); Mini-Mental State Examination (MMSE)–type tests were available at the end of treatment (mean duration: 5 y) in the 7 global cognition trials (20,431 individuals).</p><p><bold>Results</bold>: The domain-composite and MMSE-type global cognitive function <italic>z</italic> scores both decreased with age (mean ± SE: −0.054 ± 0.004 and −0.036 ± 0.001/y, respectively). Allocation to B vitamins lowered homocysteine concentrations by 28% in the cognitive-domain trials but had no significant effects on the <italic>z</italic> score differences from baseline for individual domains or for global cognitive function (<italic>z</italic> score difference: 0.00; 95% CI: −0.05, 0.06). Likewise, allocation to B vitamins lowered homocysteine by 26% in the global cognition trials but also had no significant effect on end-treatment MMSE-type global cognitive function (<italic>z</italic> score difference: −0.01; 95% CI: −0.03, 0.02). Overall, the effect of a 25% reduction in homocysteine equated to 0.02 y (95% CI: −0.10, 0.13 y) of cognitive aging per year and excluded reductions of >1 mo per year of treatment.</p><p><bold>Conclusion:</bold> Homocysteine lowering by using B vitamins had no significant effect on individual cognitive domains or global cognitive function or on cognitive aging.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mayeux, R" uniqKey="Mayeux R">R Mayeux</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clarke, R" uniqKey="Clarke R">R Clarke</name></author><author><name sortKey="Smith, Ad" uniqKey="Smith A">AD Smith</name></author><author><name sortKey="Jobst, K" uniqKey="Jobst K">K Jobst</name></author><author><name sortKey="Sutton, L" uniqKey="Sutton L">L Sutton</name></author><author><name sortKey="Refsum, H" uniqKey="Refsum H">H Refsum</name></author><author><name sortKey="Ueland, Pm" uniqKey="Ueland 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Am J Clin Nutr</journal-id><journal-id journal-id-type="iso-abbrev">Am. J. Clin. Nutr</journal-id><journal-id journal-id-type="publisher-id">ajcn</journal-id><journal-title-group><journal-title>The American Journal of Clinical Nutrition</journal-title></journal-title-group><issn pub-type="ppub">0002-9165</issn><issn pub-type="epub">1938-3207</issn><publisher><publisher-name>American Society for Nutrition</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24965307</article-id><article-id pub-id-type="pmc">4095663</article-id><article-id pub-id-type="publisher-id">076349</article-id><article-id pub-id-type="doi">10.3945/ajcn.113.076349</article-id><article-categories><subj-group subj-group-type="heading"><subject>Nutritional Epidemiology and Public Health</subject></subj-group></article-categories><title-group><article-title>Effects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals<xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="author-notes" rid="fn1"><sup>2</sup></xref><xref ref-type="author-notes" rid="fn2"><sup>3</sup></xref><xref ref-type="author-notes" rid="fn3"><sup>4</sup></xref><xref ref-type="corresp" rid="cor1"><sup>5</sup></xref></article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Clarke</surname><given-names>Robert</given-names></name></contrib><contrib contrib-type="author"><name><surname>Bennett</surname><given-names>Derrick</given-names></name></contrib><contrib contrib-type="author"><name><surname>Parish</surname><given-names>Sarah</given-names></name></contrib><contrib contrib-type="author"><name><surname>Lewington</surname><given-names>Sarah</given-names></name></contrib><contrib contrib-type="author"><name><surname>Skeaff</surname><given-names>Murray</given-names></name></contrib><contrib contrib-type="author"><name><surname>Eussen</surname><given-names>Simone JPM</given-names></name></contrib><contrib contrib-type="author"><name><surname>Lewerin</surname><given-names>Catharina</given-names></name></contrib><contrib contrib-type="author"><name><surname>Stott</surname><given-names>David J</given-names></name></contrib><contrib contrib-type="author"><name><surname>Armitage</surname><given-names>Jane</given-names></name></contrib><contrib contrib-type="author"><name><surname>Hankey</surname><given-names>Graeme J</given-names></name></contrib><contrib contrib-type="author"><name><surname>Lonn</surname><given-names>Eva</given-names></name></contrib><contrib contrib-type="author"><name><surname>Spence</surname><given-names>J David</given-names></name></contrib><contrib contrib-type="author"><name><surname>Galan</surname><given-names>Pilar</given-names></name></contrib><contrib contrib-type="author"><name><surname>de Groot</surname><given-names>Lisette C</given-names></name></contrib><contrib contrib-type="author"><name><surname>Halsey</surname><given-names>Jim</given-names></name></contrib><contrib contrib-type="author"><name><surname>Dangour</surname><given-names>Alan D</given-names></name></contrib><contrib contrib-type="author"><name><surname>Collins</surname><given-names>Rory</given-names></name></contrib><contrib contrib-type="author"><name><surname>Grodstein</surname><given-names>Francine</given-names></name></contrib><contrib contrib-type="author"><collab>on behalf of the B-Vitamin Treatment Trialists’ Collaboration</collab></contrib><aff id="aff1"><label>1</label>From the Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, United Kingdom (R Clarke, DB, SP, SL, JA, JH, and R Collins); the Department of Human Nutrition, University of Otago, Dunedin, New Zealand (MS); the Section for Pharmacology and Department of Public Health and Primary Care, University of Bergen, Bergen, Norway (SJPME); the Department of Epidemiology, School for Public Health and Primary Care, CAPHRI, Maastricht University Medical Centre, Maastricht, Netherlands (SJPME); the Section of Hematology and Coagulation, Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden (CL); the Division of Cardiovascular and Medical Science, University of Glasgow, Glasgow, United Kingdom (DJS); the School of Medicine and Pharmacology, The University of Western Australia, Perth, Australia (GJH); the Population Health Research Institute and Department of Medicine, McMaster University, Hamilton, Canada (EL); the Department of Neurology, Western University, London, Canada (JDS); Unité de Recherche en Epidémiologie Nutritonnelle (UREN), Sorbonne-Paris-Cité, UMR Inserm U557, France (PG); Inra U1125, Paris, France (PG); Cnam, Paris, France (PG); Université Paris 13, CRNH IdF, Bobigny, France (PG); the Division of Human Nutrition and Epidemiology, Wageningen University, Wageningen, Netherlands (LCdG); the Department of Nutrition and Public Health Intervention Research, London School of Hygiene and Tropical Medicine, London, United Kingdom (ADD); and the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA (FG).</aff></contrib-group><author-notes><fn id="fn1"><label>2</label><p>Investigators in the B-Vitamin Treatment Trialists’ Collaboration are listed in <bold><xref ref-type="app" rid="app1">Appendix A</xref></bold> after the References.</p></fn><fn id="fn2"><label>3</label><p>R Clarke, DB, and SP contributed equally to this article.</p></fn><fn id="fn3"><label>4</label><p>Supported by the British Heart Foundation, the UK Medical Research Council, Cancer Research UK, and the UK Food Standards Agency (N05072) and Department of Health. Sources of funding for the individual trials are described in their separate publications. The Clinical Trial Service Unit and Epidemiological Studies Unit, where the B-Vitamin Treatment Trialists’ Collaboration Secretariat is located, has a policy of not accepting fees, honoraria, or paid consultancies directly or indirectly from industry. It receives funding from the British Heart Foundation, UK Medical Research Council, and Cancer Research UK. This is an open access article distributed under the CC-BY license (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/3.0/">http://creativecommons.org/licenses/by/3.0/</ext-link>).</p></fn><corresp id="cor1"><label>5</label>Address correspondence to R Clarke, Clinical Trial Service Unit and Epidemiological Studies Unit, Richard Doll Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7LF, United Kingdom. E-mail: <email xlink:type="simple">robert.clarke@ctsu.ox.ac.uk</email>.</corresp></author-notes><pmc-comment>Fake ppub date generated by PMC from publisher pub-date/@pub-type='epub-ppub' </pmc-comment>
<pub-date pub-type="ppub"><month>8</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>25</day><month>6</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>25</day><month>6</month><year>2014</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>100</volume><issue>2</issue><fpage>657</fpage><lpage>666</lpage><history><date date-type="received"><day>28</day><month>9</month><year>2013</year></date><date date-type="accepted"><day>8</day><month>5</month><year>2014</year></date></history><permissions><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/3.0/"><license-p>This is an open access article distributed under the CC-BY license (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/3.0/">http://creativecommons.org/licenses/by/3.0/</ext-link>).</license-p></license></permissions><abstract><p><bold>Background:</bold> Elevated plasma homocysteine is a risk factor for Alzheimer disease, but the relevance of homocysteine lowering to slow the rate of cognitive aging is uncertain.</p><p><bold>Objective:</bold> The aim was to assess the effects of treatment with B vitamins compared with placebo, when administered for several years, on composite domains of cognitive function, global cognitive function, and cognitive aging.</p><p><bold>Design:</bold> A meta-analysis was conducted by using data combined from 11 large trials in 22,000 participants. Domain-based <italic>z</italic> scores (for memory, speed, and executive function and a domain-composite score for global cognitive function) were available before and after treatment (mean duration: 2.3 y) in the 4 cognitive-domain trials (1340 individuals); Mini-Mental State Examination (MMSE)–type tests were available at the end of treatment (mean duration: 5 y) in the 7 global cognition trials (20,431 individuals).</p><p><bold>Results</bold>: The domain-composite and MMSE-type global cognitive function <italic>z</italic> scores both decreased with age (mean ± SE: −0.054 ± 0.004 and −0.036 ± 0.001/y, respectively). Allocation to B vitamins lowered homocysteine concentrations by 28% in the cognitive-domain trials but had no significant effects on the <italic>z</italic> score differences from baseline for individual domains or for global cognitive function (<italic>z</italic> score difference: 0.00; 95% CI: −0.05, 0.06). Likewise, allocation to B vitamins lowered homocysteine by 26% in the global cognition trials but also had no significant effect on end-treatment MMSE-type global cognitive function (<italic>z</italic> score difference: −0.01; 95% CI: −0.03, 0.02). Overall, the effect of a 25% reduction in homocysteine equated to 0.02 y (95% CI: −0.10, 0.13 y) of cognitive aging per year and excluded reductions of >1 mo per year of treatment.</p><p><bold>Conclusion:</bold> Homocysteine lowering by using B vitamins had no significant effect on individual cognitive domains or global cognitive function or on cognitive aging.</p></abstract><counts><page-count count="10"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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