Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease
Identifieur interne : 002078 ( Pmc/Curation ); précédent : 002077; suivant : 002079Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease
Auteurs : Jonathan M. Schott [Royaume-Uni] ; Sebastian J. Crutch [Royaume-Uni] ; Minerva M. Carrasquillo [États-Unis] ; James Uphill [Royaume-Uni] ; Tim J. Shakespeare [Royaume-Uni] ; Natalie S. Ryan [Royaume-Uni] ; Keir X. Yong [Royaume-Uni] ; Manja Lehmann [Royaume-Uni] ; Nilufer Ertekin-Taner [États-Unis] ; Neill R. Graff-Radford [États-Unis] ; Bradley F. Boeve [États-Unis] ; Melissa E. Murray [États-Unis] ; Qurat Ul Ain Khan [États-Unis] ; Ronald C. Petersen [États-Unis] ; Dennis W. Dickson [États-Unis] ; David S. Knopman [États-Unis] ; Gil D. Rabinovici [États-Unis] ; Bruce L. Miller [États-Unis] ; Aida Suárez González [Royaume-Uni, Espagne] ; Eulogio Gil-Néciga [Espagne] ; Julie S. Snowden [Royaume-Uni] ; Jenny Harris [Royaume-Uni] ; Stuart M. Pickering-Brown [Royaume-Uni] ; Eva Louwersheimer [Pays-Bas] ; Wiesje M. Van Der Flier [Pays-Bas] ; Philip Scheltens [Pays-Bas] ; Yolande A. Pijnenburg [Pays-Bas] ; Douglas Galasko [Pays-Bas, États-Unis] ; Marie Sarazin [France] ; Bruno Dubois [France] ; Eloi Magnin [France] ; Daniela Galimberti [Italie] ; Elio Scarpini [Italie] ; Stefano F. Cappa [Italie] ; John R. Hodges [Australie] ; Glenda M. Halliday [Australie] ; Lauren Bartley [Australie] ; Maria C. Carrillo [États-Unis] ; Jose T. Bras [Royaume-Uni] ; John Hardy [Royaume-Uni] ; Martin N. Rossor [Royaume-Uni] ; John Collinge [Royaume-Uni] ; Nick C. Fox [Royaume-Uni] ; Simon Mead [Royaume-Uni]Source :
- Alzheimer's & Dementia [ 1552-5260 ] ; 2016.
Abstract
The genetics underlying posterior cortical atrophy (PCA), typically a rare variant of Alzheimer's disease (AD), remain uncertain.
We genotyped 302 PCA patients from 11 centers, calculated risk at 24 loci for AD/DLB and performed an exploratory genome-wide association study.
We confirm that variation in/near
We provide evidence for genetic risk factors specifically related to PCA. We identify three candidate loci that, if replicated, may provide insights into selective vulnerability and phenotypic diversity in AD.
Url:
DOI: 10.1016/j.jalz.2016.01.010
PubMed: 26993346
PubMed Central: 4982482
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Yong</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London</wicri:regionArea></affiliation></author><author><name sortKey="Lehmann, Manja" sort="Lehmann, Manja" uniqKey="Lehmann M" first="Manja" last="Lehmann">Manja Lehmann</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London</wicri:regionArea></affiliation></author><author><name sortKey="Ertekin Taner, Nilufer" sort="Ertekin Taner, Nilufer" uniqKey="Ertekin Taner N" first="Nilufer" last="Ertekin-Taner">Nilufer Ertekin-Taner</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea></affiliation></author><author><name sortKey="Graff Radford, Neill R" sort="Graff Radford, Neill R" uniqKey="Graff Radford N" first="Neill R." last="Graff-Radford">Neill R. Graff-Radford</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea></affiliation></author><author><name sortKey="Boeve, Bradley F" sort="Boeve, Bradley F" uniqKey="Boeve B" first="Bradley F." last="Boeve">Bradley F. Boeve</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Neurology, Mayo Clinic, Rochester, MN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, MN</wicri:regionArea></affiliation></author><author><name sortKey="Murray, Melissa E" sort="Murray, Melissa E" uniqKey="Murray M" first="Melissa E." last="Murray">Melissa E. Murray</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea></affiliation></author><author><name sortKey="Khan, Qurat Ul Ain" sort="Khan, Qurat Ul Ain" uniqKey="Khan Q" first="Qurat Ul Ain" last="Khan">Qurat Ul Ain Khan</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea></affiliation></author><author><name sortKey="Petersen, Ronald C" sort="Petersen, Ronald C" uniqKey="Petersen R" first="Ronald C." last="Petersen">Ronald C. Petersen</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Neurology, Mayo Clinic, Rochester, MN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, MN</wicri:regionArea></affiliation></author><author><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W." last="Dickson">Dennis W. Dickson</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea></affiliation></author><author><name sortKey="Knopman, David S" sort="Knopman, David S" uniqKey="Knopman D" first="David S." last="Knopman">David S. Knopman</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Neurology, Mayo Clinic, Rochester, MN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, MN</wicri:regionArea></affiliation></author><author><name sortKey="Rabinovici, Gil D" sort="Rabinovici, Gil D" uniqKey="Rabinovici G" first="Gil D." last="Rabinovici">Gil D. Rabinovici</name><affiliation wicri:level="1"><nlm:aff id="aff6">UCSF, San Francisco, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>UCSF, San Francisco, CA</wicri:regionArea></affiliation></author><author><name sortKey="Miller, Bruce L" sort="Miller, Bruce L" uniqKey="Miller B" first="Bruce L." last="Miller">Bruce L. Miller</name><affiliation wicri:level="1"><nlm:aff id="aff6">UCSF, San Francisco, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>UCSF, San Francisco, CA</wicri:regionArea></affiliation></author><author><name sortKey="Gonzalez, Aida Suarez" sort="Gonzalez, Aida Suarez" uniqKey="Gonzalez A" first="Aida Suárez" last="González">Aida Suárez González</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7">Memory Disorders Unit, Department of Neurology, University Hospital Virgen del Rocio, Seville, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Memory Disorders Unit, Department of Neurology, University Hospital Virgen del Rocio, Seville</wicri:regionArea></affiliation></author><author><name sortKey="Gil Neciga, Eulogio" sort="Gil Neciga, Eulogio" uniqKey="Gil Neciga E" first="Eulogio" last="Gil-Néciga">Eulogio Gil-Néciga</name><affiliation wicri:level="1"><nlm:aff id="aff7">Memory Disorders Unit, Department of Neurology, University Hospital Virgen del Rocio, Seville, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Memory Disorders Unit, Department of Neurology, University Hospital Virgen del Rocio, Seville</wicri:regionArea></affiliation></author><author><name sortKey="Snowden, Julie S" sort="Snowden, Julie S" uniqKey="Snowden J" first="Julie S." last="Snowden">Julie S. Snowden</name><affiliation wicri:level="1"><nlm:aff id="aff8">Institute of Brain, Behaviour and Mental Health, University of Manchester, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Brain, Behaviour and Mental Health, University of Manchester</wicri:regionArea></affiliation></author><author><name sortKey="Harris, Jenny" sort="Harris, Jenny" uniqKey="Harris J" first="Jenny" last="Harris">Jenny Harris</name><affiliation wicri:level="1"><nlm:aff id="aff8">Institute of Brain, Behaviour and Mental Health, University of Manchester, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Brain, Behaviour and Mental Health, University of Manchester</wicri:regionArea></affiliation></author><author><name sortKey="Pickering Brown, Stuart M" sort="Pickering Brown, Stuart M" uniqKey="Pickering Brown S" first="Stuart M." last="Pickering-Brown">Stuart M. Pickering-Brown</name><affiliation wicri:level="1"><nlm:aff id="aff8">Institute of Brain, Behaviour and Mental Health, University of Manchester, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Brain, Behaviour and Mental Health, University of Manchester</wicri:regionArea></affiliation></author><author><name sortKey="Louwersheimer, Eva" sort="Louwersheimer, Eva" uniqKey="Louwersheimer E" first="Eva" last="Louwersheimer">Eva Louwersheimer</name><affiliation wicri:level="1"><nlm:aff id="aff9">Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus, Amsterdam, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Flier, Wiesje M" sort="Van Der Flier, Wiesje M" uniqKey="Van Der Flier W" first="Wiesje M." last="Van Der Flier">Wiesje M. Van Der Flier</name><affiliation wicri:level="1"><nlm:aff id="aff9">Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus, Amsterdam, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Scheltens, Philip" sort="Scheltens, Philip" uniqKey="Scheltens P" first="Philip" last="Scheltens">Philip Scheltens</name><affiliation wicri:level="1"><nlm:aff id="aff9">Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus, Amsterdam, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Pijnenburg, Yolande A" sort="Pijnenburg, Yolande A" uniqKey="Pijnenburg Y" first="Yolande A." last="Pijnenburg">Yolande A. Pijnenburg</name><affiliation wicri:level="1"><nlm:aff id="aff9">Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus, Amsterdam, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Galasko, Douglas" sort="Galasko, Douglas" uniqKey="Galasko D" first="Douglas" last="Galasko">Douglas Galasko</name><affiliation wicri:level="1"><nlm:aff id="aff10">Department of Epidemiology & Biostatistics, VU University Medical Center, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology & Biostatistics, VU University Medical Center, Amsterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff11">UC San Diego/VA San Diego Healthcare System, San Diego, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>UC San Diego/VA San Diego Healthcare System, San Diego, CA</wicri:regionArea></affiliation></author><author><name sortKey="Sarazin, Marie" sort="Sarazin, Marie" uniqKey="Sarazin M" first="Marie" last="Sarazin">Marie Sarazin</name><affiliation wicri:level="1"><nlm:aff id="aff12">INSERM U610, Hôpital de la Salpêtrière, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U610, Hôpital de la Salpêtrière, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Dubois, Bruno" sort="Dubois, Bruno" uniqKey="Dubois B" first="Bruno" last="Dubois">Bruno Dubois</name><affiliation wicri:level="1"><nlm:aff id="aff13">Centre des Maladies Cognitives et Comportementales, IM2A, ICM, Paris 6 University, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre des Maladies Cognitives et Comportementales, IM2A, ICM, Paris 6 University</wicri:regionArea></affiliation></author><author><name sortKey="Magnin, Eloi" sort="Magnin, Eloi" uniqKey="Magnin E" first="Eloi" last="Magnin">Eloi Magnin</name><affiliation wicri:level="1"><nlm:aff id="aff14">Regional Memory Centre (CMRR), CHU Besançon, Besançon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Regional Memory Centre (CMRR), CHU Besançon, Besançon</wicri:regionArea></affiliation></author><author><name sortKey="Galimberti, Daniela" sort="Galimberti, Daniela" uniqKey="Galimberti D" first="Daniela" last="Galimberti">Daniela Galimberti</name><affiliation wicri:level="1"><nlm:aff id="aff15">University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico</wicri:regionArea></affiliation></author><author><name sortKey="Scarpini, Elio" sort="Scarpini, Elio" uniqKey="Scarpini E" first="Elio" last="Scarpini">Elio Scarpini</name><affiliation wicri:level="1"><nlm:aff id="aff15">University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico</wicri:regionArea></affiliation></author><author><name sortKey="Cappa, Stefano F" sort="Cappa, Stefano F" uniqKey="Cappa S" first="Stefano F." last="Cappa">Stefano F. Cappa</name><affiliation wicri:level="1"><nlm:aff id="aff16">Vita-Salute San Raffaele University, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Vita-Salute San Raffaele University, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Hodges, John R" sort="Hodges, John R" uniqKey="Hodges J" first="John R." last="Hodges">John R. Hodges</name><affiliation wicri:level="1"><nlm:aff id="aff17">University of New South Wales, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>University of New South Wales, Sydney</wicri:regionArea></affiliation></author><author><name sortKey="Halliday, Glenda M" sort="Halliday, Glenda M" uniqKey="Halliday G" first="Glenda M." last="Halliday">Glenda M. Halliday</name><affiliation wicri:level="1"><nlm:aff id="aff17">University of New South Wales, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>University of New South Wales, Sydney</wicri:regionArea></affiliation></author><author><name sortKey="Bartley, Lauren" sort="Bartley, Lauren" uniqKey="Bartley L" first="Lauren" last="Bartley">Lauren Bartley</name><affiliation wicri:level="1"><nlm:aff id="aff17">University of New South Wales, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>University of New South Wales, Sydney</wicri:regionArea></affiliation></author><author><name sortKey="Carrillo, Maria C" sort="Carrillo, Maria C" uniqKey="Carrillo M" first="Maria C." last="Carrillo">Maria C. Carrillo</name><affiliation wicri:level="1"><nlm:aff id="aff18">Alzheimer's Association, Chicago, IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Alzheimer's Association, Chicago, IL</wicri:regionArea></affiliation></author><author><name sortKey="Bras, Jose T" sort="Bras, Jose T" uniqKey="Bras J" first="Jose T." last="Bras">Jose T. Bras</name><affiliation wicri:level="1"><nlm:aff id="aff19">Department of Molecular Neurosciences, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Molecular Neurosciences, UCL Institute of Neurology, London</wicri:regionArea></affiliation></author><author><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name><affiliation wicri:level="1"><nlm:aff id="aff19">Department of Molecular Neurosciences, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Molecular Neurosciences, UCL Institute of Neurology, London</wicri:regionArea></affiliation></author><author><name sortKey="Rossor, Martin N" sort="Rossor, Martin N" uniqKey="Rossor M" first="Martin N." last="Rossor">Martin N. Rossor</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London</wicri:regionArea></affiliation></author><author><name sortKey="Collinge, John" sort="Collinge, John" uniqKey="Collinge J" first="John" last="Collinge">John Collinge</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London</wicri:regionArea></affiliation></author><author><name sortKey="Fox, Nick C" sort="Fox, Nick C" uniqKey="Fox N" first="Nick C." last="Fox">Nick C. Fox</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London</wicri:regionArea></affiliation></author><author><name sortKey="Mead, Simon" sort="Mead, Simon" uniqKey="Mead S" first="Simon" last="Mead">Simon Mead</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26993346</idno><idno type="pmc">4982482</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982482</idno><idno type="RBID">PMC:4982482</idno><idno type="doi">10.1016/j.jalz.2016.01.010</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">002228</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002228</idno><idno type="wicri:Area/Pmc/Curation">002078</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002078</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease</title><author><name sortKey="Schott, Jonathan M" sort="Schott, Jonathan M" uniqKey="Schott J" first="Jonathan M." last="Schott">Jonathan M. Schott</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London</wicri:regionArea></affiliation></author><author><name sortKey="Crutch, Sebastian J" sort="Crutch, Sebastian J" uniqKey="Crutch S" first="Sebastian J." last="Crutch">Sebastian J. Crutch</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London</wicri:regionArea></affiliation></author><author><name sortKey="Carrasquillo, Minerva M" sort="Carrasquillo, Minerva M" uniqKey="Carrasquillo M" first="Minerva M." last="Carrasquillo">Minerva M. Carrasquillo</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea></affiliation></author><author><name sortKey="Uphill, James" sort="Uphill, James" uniqKey="Uphill J" first="James" last="Uphill">James Uphill</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London</wicri:regionArea></affiliation></author><author><name sortKey="Shakespeare, Tim J" sort="Shakespeare, Tim J" uniqKey="Shakespeare T" first="Tim J." last="Shakespeare">Tim J. Shakespeare</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London</wicri:regionArea></affiliation></author><author><name sortKey="Ryan, Natalie S" sort="Ryan, Natalie S" uniqKey="Ryan N" first="Natalie S." last="Ryan">Natalie S. Ryan</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London</wicri:regionArea></affiliation></author><author><name sortKey="Yong, Keir X" sort="Yong, Keir X" uniqKey="Yong K" first="Keir X." last="Yong">Keir X. Yong</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London</wicri:regionArea></affiliation></author><author><name sortKey="Lehmann, Manja" sort="Lehmann, Manja" uniqKey="Lehmann M" first="Manja" last="Lehmann">Manja Lehmann</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London</wicri:regionArea></affiliation></author><author><name sortKey="Ertekin Taner, Nilufer" sort="Ertekin Taner, Nilufer" uniqKey="Ertekin Taner N" first="Nilufer" last="Ertekin-Taner">Nilufer Ertekin-Taner</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea></affiliation></author><author><name sortKey="Graff Radford, Neill R" sort="Graff Radford, Neill R" uniqKey="Graff Radford N" first="Neill R." last="Graff-Radford">Neill R. Graff-Radford</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea></affiliation></author><author><name sortKey="Boeve, Bradley F" sort="Boeve, Bradley F" uniqKey="Boeve B" first="Bradley F." last="Boeve">Bradley F. Boeve</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Neurology, Mayo Clinic, Rochester, MN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, MN</wicri:regionArea></affiliation></author><author><name sortKey="Murray, Melissa E" sort="Murray, Melissa E" uniqKey="Murray M" first="Melissa E." last="Murray">Melissa E. Murray</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea></affiliation></author><author><name sortKey="Khan, Qurat Ul Ain" sort="Khan, Qurat Ul Ain" uniqKey="Khan Q" first="Qurat Ul Ain" last="Khan">Qurat Ul Ain Khan</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea></affiliation></author><author><name sortKey="Petersen, Ronald C" sort="Petersen, Ronald C" uniqKey="Petersen R" first="Ronald C." last="Petersen">Ronald C. Petersen</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Neurology, Mayo Clinic, Rochester, MN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, MN</wicri:regionArea></affiliation></author><author><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W." last="Dickson">Dennis W. Dickson</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea></affiliation></author><author><name sortKey="Knopman, David S" sort="Knopman, David S" uniqKey="Knopman D" first="David S." last="Knopman">David S. Knopman</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Neurology, Mayo Clinic, Rochester, MN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, MN</wicri:regionArea></affiliation></author><author><name sortKey="Rabinovici, Gil D" sort="Rabinovici, Gil D" uniqKey="Rabinovici G" first="Gil D." last="Rabinovici">Gil D. Rabinovici</name><affiliation wicri:level="1"><nlm:aff id="aff6">UCSF, San Francisco, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>UCSF, San Francisco, CA</wicri:regionArea></affiliation></author><author><name sortKey="Miller, Bruce L" sort="Miller, Bruce L" uniqKey="Miller B" first="Bruce L." last="Miller">Bruce L. Miller</name><affiliation wicri:level="1"><nlm:aff id="aff6">UCSF, San Francisco, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>UCSF, San Francisco, CA</wicri:regionArea></affiliation></author><author><name sortKey="Gonzalez, Aida Suarez" sort="Gonzalez, Aida Suarez" uniqKey="Gonzalez A" first="Aida Suárez" last="González">Aida Suárez González</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7">Memory Disorders Unit, Department of Neurology, University Hospital Virgen del Rocio, Seville, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Memory Disorders Unit, Department of Neurology, University Hospital Virgen del Rocio, Seville</wicri:regionArea></affiliation></author><author><name sortKey="Gil Neciga, Eulogio" sort="Gil Neciga, Eulogio" uniqKey="Gil Neciga E" first="Eulogio" last="Gil-Néciga">Eulogio Gil-Néciga</name><affiliation wicri:level="1"><nlm:aff id="aff7">Memory Disorders Unit, Department of Neurology, University Hospital Virgen del Rocio, Seville, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Memory Disorders Unit, Department of Neurology, University Hospital Virgen del Rocio, Seville</wicri:regionArea></affiliation></author><author><name sortKey="Snowden, Julie S" sort="Snowden, Julie S" uniqKey="Snowden J" first="Julie S." last="Snowden">Julie S. Snowden</name><affiliation wicri:level="1"><nlm:aff id="aff8">Institute of Brain, Behaviour and Mental Health, University of Manchester, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Brain, Behaviour and Mental Health, University of Manchester</wicri:regionArea></affiliation></author><author><name sortKey="Harris, Jenny" sort="Harris, Jenny" uniqKey="Harris J" first="Jenny" last="Harris">Jenny Harris</name><affiliation wicri:level="1"><nlm:aff id="aff8">Institute of Brain, Behaviour and Mental Health, University of Manchester, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Brain, Behaviour and Mental Health, University of Manchester</wicri:regionArea></affiliation></author><author><name sortKey="Pickering Brown, Stuart M" sort="Pickering Brown, Stuart M" uniqKey="Pickering Brown S" first="Stuart M." last="Pickering-Brown">Stuart M. Pickering-Brown</name><affiliation wicri:level="1"><nlm:aff id="aff8">Institute of Brain, Behaviour and Mental Health, University of Manchester, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Brain, Behaviour and Mental Health, University of Manchester</wicri:regionArea></affiliation></author><author><name sortKey="Louwersheimer, Eva" sort="Louwersheimer, Eva" uniqKey="Louwersheimer E" first="Eva" last="Louwersheimer">Eva Louwersheimer</name><affiliation wicri:level="1"><nlm:aff id="aff9">Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus, Amsterdam, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Flier, Wiesje M" sort="Van Der Flier, Wiesje M" uniqKey="Van Der Flier W" first="Wiesje M." last="Van Der Flier">Wiesje M. Van Der Flier</name><affiliation wicri:level="1"><nlm:aff id="aff9">Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus, Amsterdam, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Scheltens, Philip" sort="Scheltens, Philip" uniqKey="Scheltens P" first="Philip" last="Scheltens">Philip Scheltens</name><affiliation wicri:level="1"><nlm:aff id="aff9">Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus, Amsterdam, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Pijnenburg, Yolande A" sort="Pijnenburg, Yolande A" uniqKey="Pijnenburg Y" first="Yolande A." last="Pijnenburg">Yolande A. Pijnenburg</name><affiliation wicri:level="1"><nlm:aff id="aff9">Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus, Amsterdam, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Galasko, Douglas" sort="Galasko, Douglas" uniqKey="Galasko D" first="Douglas" last="Galasko">Douglas Galasko</name><affiliation wicri:level="1"><nlm:aff id="aff10">Department of Epidemiology & Biostatistics, VU University Medical Center, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology & Biostatistics, VU University Medical Center, Amsterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff11">UC San Diego/VA San Diego Healthcare System, San Diego, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>UC San Diego/VA San Diego Healthcare System, San Diego, CA</wicri:regionArea></affiliation></author><author><name sortKey="Sarazin, Marie" sort="Sarazin, Marie" uniqKey="Sarazin M" first="Marie" last="Sarazin">Marie Sarazin</name><affiliation wicri:level="1"><nlm:aff id="aff12">INSERM U610, Hôpital de la Salpêtrière, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U610, Hôpital de la Salpêtrière, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Dubois, Bruno" sort="Dubois, Bruno" uniqKey="Dubois B" first="Bruno" last="Dubois">Bruno Dubois</name><affiliation wicri:level="1"><nlm:aff id="aff13">Centre des Maladies Cognitives et Comportementales, IM2A, ICM, Paris 6 University, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre des Maladies Cognitives et Comportementales, IM2A, ICM, Paris 6 University</wicri:regionArea></affiliation></author><author><name sortKey="Magnin, Eloi" sort="Magnin, Eloi" uniqKey="Magnin E" first="Eloi" last="Magnin">Eloi Magnin</name><affiliation wicri:level="1"><nlm:aff id="aff14">Regional Memory Centre (CMRR), CHU Besançon, Besançon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Regional Memory Centre (CMRR), CHU Besançon, Besançon</wicri:regionArea></affiliation></author><author><name sortKey="Galimberti, Daniela" sort="Galimberti, Daniela" uniqKey="Galimberti D" first="Daniela" last="Galimberti">Daniela Galimberti</name><affiliation wicri:level="1"><nlm:aff id="aff15">University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico</wicri:regionArea></affiliation></author><author><name sortKey="Scarpini, Elio" sort="Scarpini, Elio" uniqKey="Scarpini E" first="Elio" last="Scarpini">Elio Scarpini</name><affiliation wicri:level="1"><nlm:aff id="aff15">University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico</wicri:regionArea></affiliation></author><author><name sortKey="Cappa, Stefano F" sort="Cappa, Stefano F" uniqKey="Cappa S" first="Stefano F." last="Cappa">Stefano F. Cappa</name><affiliation wicri:level="1"><nlm:aff id="aff16">Vita-Salute San Raffaele University, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Vita-Salute San Raffaele University, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Hodges, John R" sort="Hodges, John R" uniqKey="Hodges J" first="John R." last="Hodges">John R. Hodges</name><affiliation wicri:level="1"><nlm:aff id="aff17">University of New South Wales, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>University of New South Wales, Sydney</wicri:regionArea></affiliation></author><author><name sortKey="Halliday, Glenda M" sort="Halliday, Glenda M" uniqKey="Halliday G" first="Glenda M." last="Halliday">Glenda M. Halliday</name><affiliation wicri:level="1"><nlm:aff id="aff17">University of New South Wales, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>University of New South Wales, Sydney</wicri:regionArea></affiliation></author><author><name sortKey="Bartley, Lauren" sort="Bartley, Lauren" uniqKey="Bartley L" first="Lauren" last="Bartley">Lauren Bartley</name><affiliation wicri:level="1"><nlm:aff id="aff17">University of New South Wales, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>University of New South Wales, Sydney</wicri:regionArea></affiliation></author><author><name sortKey="Carrillo, Maria C" sort="Carrillo, Maria C" uniqKey="Carrillo M" first="Maria C." last="Carrillo">Maria C. Carrillo</name><affiliation wicri:level="1"><nlm:aff id="aff18">Alzheimer's Association, Chicago, IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Alzheimer's Association, Chicago, IL</wicri:regionArea></affiliation></author><author><name sortKey="Bras, Jose T" sort="Bras, Jose T" uniqKey="Bras J" first="Jose T." last="Bras">Jose T. Bras</name><affiliation wicri:level="1"><nlm:aff id="aff19">Department of Molecular Neurosciences, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Molecular Neurosciences, UCL Institute of Neurology, London</wicri:regionArea></affiliation></author><author><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name><affiliation wicri:level="1"><nlm:aff id="aff19">Department of Molecular Neurosciences, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Molecular Neurosciences, UCL Institute of Neurology, London</wicri:regionArea></affiliation></author><author><name sortKey="Rossor, Martin N" sort="Rossor, Martin N" uniqKey="Rossor M" first="Martin N." last="Rossor">Martin N. Rossor</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London</wicri:regionArea></affiliation></author><author><name sortKey="Collinge, John" sort="Collinge, John" uniqKey="Collinge J" first="John" last="Collinge">John Collinge</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London</wicri:regionArea></affiliation></author><author><name sortKey="Fox, Nick C" sort="Fox, Nick C" uniqKey="Fox N" first="Nick C." last="Fox">Nick C. Fox</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London</wicri:regionArea></affiliation></author><author><name sortKey="Mead, Simon" sort="Mead, Simon" uniqKey="Mead S" first="Simon" last="Mead">Simon Mead</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London</wicri:regionArea></affiliation></author></analytic><series><title level="j">Alzheimer's & Dementia</title><idno type="ISSN">1552-5260</idno><idno type="eISSN">1552-5279</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Introduction</title><p>The genetics underlying posterior cortical atrophy (PCA), typically a rare variant of Alzheimer's disease (AD), remain uncertain.</p></sec><sec><title>Methods</title><p>We genotyped 302 PCA patients from 11 centers, calculated risk at 24 loci for AD/DLB and performed an exploratory genome-wide association study.</p></sec><sec><title>Results</title><p>We confirm that variation in/near <italic>APOE/TOMM40</italic> (<italic>P</italic> = 6 × 10<sup>−14</sup>) alters PCA risk, but with smaller effect than for typical AD (PCA: odds ratio [OR] = 2.03, typical AD: OR = 2.83, <italic>P</italic> = .0007). We found evidence for risk in/near <italic>CR1</italic> (<italic>P</italic> = 7 × 10<sup>−4</sup>), <italic>ABCA7</italic> (<italic>P</italic> = .02) and <italic>BIN1</italic> (<italic>P</italic> = .04). ORs at variants near <italic>INPP5D</italic> and <italic>NME8</italic> did not overlap between PCA and typical AD. Exploratory genome-wide association studies confirmed <italic>APOE</italic> and identified three novel loci: rs76854344 near <italic>CNTNAP5</italic> (<italic>P</italic> = 8 × 10<sup>−10</sup> OR = 1.9 [1.5–2.3]); rs72907046 near <italic>FAM46A</italic> (<italic>P</italic> = 1 × 10<sup>−9</sup> OR = 3.2 [2.1–4.9]); and rs2525776 near <italic>SEMA3C</italic> (<italic>P</italic> = 1 × 10<sup>−8</sup>, OR = 3.3 [2.1–5.1]).</p></sec><sec><title>Discussion</title><p>We provide evidence for genetic risk factors specifically related to PCA. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Alzheimers Dement</journal-id><journal-id journal-id-type="iso-abbrev">Alzheimers Dement</journal-id><journal-title-group><journal-title>Alzheimer's & Dementia</journal-title></journal-title-group><issn pub-type="ppub">1552-5260</issn><issn pub-type="epub">1552-5279</issn><publisher><publisher-name>Elsevier, Inc</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26993346</article-id><article-id pub-id-type="pmc">4982482</article-id><article-id pub-id-type="publisher-id">S1552-5260(16)00077-7</article-id><article-id pub-id-type="doi">10.1016/j.jalz.2016.01.010</article-id><article-categories><subj-group subj-group-type="heading"><subject>Featured Article</subject></subj-group></article-categories><title-group><article-title>Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease</article-title></title-group><contrib-group><contrib 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contrib-type="author"><name><surname>van der Flier</surname><given-names>Wiesje M.</given-names></name><xref rid="aff9" ref-type="aff">i</xref></contrib><contrib contrib-type="author"><name><surname>Scheltens</surname><given-names>Philip</given-names></name><xref rid="aff9" ref-type="aff">i</xref></contrib><contrib contrib-type="author"><name><surname>Pijnenburg</surname><given-names>Yolande A.</given-names></name><xref rid="aff9" ref-type="aff">i</xref></contrib><contrib contrib-type="author"><name><surname>Galasko</surname><given-names>Douglas</given-names></name><xref rid="aff10" ref-type="aff">j</xref><xref rid="aff11" ref-type="aff">k</xref></contrib><contrib contrib-type="author"><name><surname>Sarazin</surname><given-names>Marie</given-names></name><xref rid="aff12" ref-type="aff">l</xref></contrib><contrib contrib-type="author"><name><surname>Dubois</surname><given-names>Bruno</given-names></name><xref rid="aff13" ref-type="aff">m</xref></contrib><contrib contrib-type="author"><name><surname>Magnin</surname><given-names>Eloi</given-names></name><xref rid="aff14" ref-type="aff">n</xref></contrib><contrib contrib-type="author"><name><surname>Galimberti</surname><given-names>Daniela</given-names></name><xref rid="aff15" ref-type="aff">o</xref></contrib><contrib contrib-type="author"><name><surname>Scarpini</surname><given-names>Elio</given-names></name><xref rid="aff15" ref-type="aff">o</xref></contrib><contrib contrib-type="author"><name><surname>Cappa</surname><given-names>Stefano F.</given-names></name><xref rid="aff16" ref-type="aff">p</xref></contrib><contrib contrib-type="author"><name><surname>Hodges</surname><given-names>John R.</given-names></name><xref rid="aff17" ref-type="aff">q</xref></contrib><contrib contrib-type="author"><name><surname>Halliday</surname><given-names>Glenda M.</given-names></name><xref rid="aff17" ref-type="aff">q</xref></contrib><contrib contrib-type="author"><name><surname>Bartley</surname><given-names>Lauren</given-names></name><xref rid="aff17" ref-type="aff">q</xref></contrib><contrib contrib-type="author"><name><surname>Carrillo</surname><given-names>Maria C.</given-names></name><xref rid="aff18" ref-type="aff">r</xref></contrib><contrib contrib-type="author"><name><surname>Bras</surname><given-names>Jose T.</given-names></name><xref rid="aff19" ref-type="aff">s</xref></contrib><contrib contrib-type="author"><name><surname>Hardy</surname><given-names>John</given-names></name><xref rid="aff19" ref-type="aff">s</xref></contrib><contrib contrib-type="author"><name><surname>Rossor</surname><given-names>Martin N.</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Collinge</surname><given-names>John</given-names></name><xref rid="aff3" ref-type="aff">c</xref></contrib><contrib contrib-type="author"><name><surname>Fox</surname><given-names>Nick C.</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Mead</surname><given-names>Simon</given-names></name><xref rid="aff3" ref-type="aff">c</xref></contrib></contrib-group><aff id="aff1"><label>a</label>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK</aff><aff id="aff2"><label>b</label>Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA</aff><aff id="aff3"><label>c</label>Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK</aff><aff id="aff4"><label>d</label>Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</aff><aff id="aff5"><label>e</label>Department of Neurology, Mayo Clinic, Rochester, MN, USA</aff><aff id="aff6"><label>f</label>UCSF, San Francisco, CA, USA</aff><aff id="aff7"><label>g</label>Memory Disorders Unit, Department of Neurology, University Hospital Virgen del Rocio, Seville, Spain</aff><aff id="aff8"><label>h</label>Institute of Brain, Behaviour and Mental Health, University of Manchester, UK</aff><aff id="aff9"><label>i</label>Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus, Amsterdam, Netherlands</aff><aff id="aff10"><label>j</label>Department of Epidemiology & Biostatistics, VU University Medical Center, Amsterdam, The Netherlands</aff><aff id="aff11"><label>k</label>UC San Diego/VA San Diego Healthcare System, San Diego, CA, USA</aff><aff id="aff12"><label>l</label>INSERM U610, Hôpital de la Salpêtrière, Paris, France</aff><aff id="aff13"><label>m</label>Centre des Maladies Cognitives et Comportementales, IM2A, ICM, Paris 6 University, France</aff><aff id="aff14"><label>n</label>Regional Memory Centre (CMRR), CHU Besançon, Besançon, France</aff><aff id="aff15"><label>o</label>University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Italy</aff><aff id="aff16"><label>p</label>Vita-Salute San Raffaele University, Milan, Italy</aff><aff id="aff17"><label>q</label>University of New South Wales, Sydney, Australia</aff><aff id="aff18"><label>r</label>Alzheimer's Association, Chicago, IL, USA</aff><aff id="aff19"><label>s</label>Department of Molecular Neurosciences, UCL Institute of Neurology, London, UK</aff><author-notes><corresp id="cor1"><label>∗</label>Corresponding author. Tel.: +44 20 3448 3553; Fax: +44 20 3448 3104. <email>j.schott@ucl.ac.uk</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>1</day><month>8</month><year>2016</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>8</month><year>2016</year></pub-date><volume>12</volume><issue>8</issue><fpage>862</fpage><lpage>871</lpage><permissions><copyright-statement>© 2016 The Authors</copyright-statement><copyright-year>2016</copyright-year><license license-type="CC BY" xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).</license-p></license></permissions><abstract id="abs0010"><sec><title>Introduction</title><p>The genetics underlying posterior cortical atrophy (PCA), typically a rare variant of Alzheimer's disease (AD), remain uncertain.</p></sec><sec><title>Methods</title><p>We genotyped 302 PCA patients from 11 centers, calculated risk at 24 loci for AD/DLB and performed an exploratory genome-wide association study.</p></sec><sec><title>Results</title><p>We confirm that variation in/near <italic>APOE/TOMM40</italic> (<italic>P</italic> = 6 × 10<sup>−14</sup>) alters PCA risk, but with smaller effect than for typical AD (PCA: odds ratio [OR] = 2.03, typical AD: OR = 2.83, <italic>P</italic> = .0007). We found evidence for risk in/near <italic>CR1</italic> (<italic>P</italic> = 7 × 10<sup>−4</sup>), <italic>ABCA7</italic> (<italic>P</italic> = .02) and <italic>BIN1</italic> (<italic>P</italic> = .04). ORs at variants near <italic>INPP5D</italic> and <italic>NME8</italic> did not overlap between PCA and typical AD. Exploratory genome-wide association studies confirmed <italic>APOE</italic> and identified three novel loci: rs76854344 near <italic>CNTNAP5</italic> (<italic>P</italic> = 8 × 10<sup>−10</sup> OR = 1.9 [1.5–2.3]); rs72907046 near <italic>FAM46A</italic> (<italic>P</italic> = 1 × 10<sup>−9</sup> OR = 3.2 [2.1–4.9]); and rs2525776 near <italic>SEMA3C</italic> (<italic>P</italic> = 1 × 10<sup>−8</sup>, OR = 3.3 [2.1–5.1]).</p></sec><sec><title>Discussion</title><p>We provide evidence for genetic risk factors specifically related to PCA. We identify three candidate loci that, if replicated, may provide insights into selective vulnerability and phenotypic diversity in AD.</p></sec></abstract><kwd-group id="kwrds0010"><title>Keywords</title><kwd>Posterior cortical atrophy</kwd><kwd>Alzheimer's disease</kwd><kwd>Genetics</kwd><kwd>GWAS</kwd><kwd>Selective vulnerability</kwd><kwd><italic>APOE</italic></kwd></kwd-group></article-meta></front><floats-group><fig id="fig1"><label>Fig. 1</label><caption><p>Manhattan plot of autosomes with the threshold for genome-wide significance (<italic>P</italic> < 5 × 10<sup>−8</sup>) indicated by the red line. Four loci achieved statistical significance at <italic>APOE</italic> (chromosome 19), <italic>SEMA3C</italic> (chromosome 7), <italic>FAM46A</italic> (chromosome 6), and <italic>CNTNAP5</italic> (chromosome 2).</p></caption><graphic xlink:href="gr1"></graphic></fig><fig id="fig2"><label>Fig. 2</label><caption><p>SNP annotation and proxy (SNAP) plots for five regions of interest showing significance in either known genetic loci for AD (A, B) or in the exploratory GWAS (A,C,D,E). These plots illustrate the statistical evidence of association at a locus together with information about nearby genes and linkage disequilibrium between the most strongly associated SNP and its neighbors on the chromosome.</p></caption><graphic xlink:href="gr2"></graphic></fig><table-wrap id="tbl1" position="float"><label>Table 1</label><caption><p>Clinical criteria for PCA</p></caption><table frame="hsides" rules="groups"><thead><tr><th>Tang-Wai et al, 2004 <xref rid="bib5" ref-type="bibr">[5]</xref></th><th>Mendez et al, 2002 <xref rid="bib11" ref-type="bibr">[11]</xref></th></tr></thead><tbody><tr><td><list list-type="simple"><list-item id="u0010"><p>Core features<list list-type="simple"><list-item id="u0015"><p>Insidious onset and gradual progression</p></list-item><list-item id="u0020"><p>Presentation of visual complaints in the absence of significant primary ocular disease</p></list-item><list-item id="u0025"><p>Relative preservation of anterograde memory and insight early in the disorder</p></list-item><list-item id="u0030"><p>Disabling visual impairment throughout the disorder</p></list-item><list-item id="u0035"><p>Absence of stroke or tumor</p></list-item><list-item id="u0040"><p>Absence of early parkinsonism and hallucinations</p></list-item><list-item id="u0045"><p><italic>Any of the following findings</italic></p></list-item><list-item id="u0050"><p>Simultanagnosia with or without optic ataxia or ocular apraxia</p></list-item><list-item id="u0055"><p>Constructional dyspraxia</p></list-item><list-item id="u0060"><p>Visual field defect</p></list-item><list-item id="u0065"><p>Environmental disorientation</p></list-item><list-item id="u0070"><p>Any of the elements of Gerstmann syndrome</p></list-item></list></p></list-item><list-item id="u0075"><p>Supportive features<list list-type="simple"><list-item id="u0080"><p>Alexia</p></list-item><list-item id="u0085"><p>Presenile onset</p></list-item><list-item id="u0090"><p>Ideomotor or dressing apraxia</p></list-item><list-item id="u0095"><p>Prosopagnosia</p></list-item></list></p></list-item><list-item id="u0100"><p>Investigations<list list-type="simple"><list-item id="u0105"><p>Neuropsychological deficits referable to parietal and/or occipital regions</p></list-item><list-item id="u0110"><p>Focal or asymmetric atrophy in parietal and/or occipital regions on structural imaging</p></list-item><list-item id="u0115"><p>Focal or asymmetric hypoperfusion/hypometabolism in parietal and/or occipital regions on functional imaging.</p></list-item></list></p></list-item></list></td><td><list list-type="simple"><list-item id="u0120"><p>Core diagnostic features (all must be present)<list list-type="simple"><list-item id="u0125"><p>Insidious onset and gradual progression</p></list-item><list-item id="u0130"><p>Presentation with visual complaints with intact primary visual functions</p></list-item><list-item id="u0135"><p>Evidence of predominant complex visual disorder on examination</p></list-item><list-item id="u0140"><p>Elements of Balint's syndrome</p></list-item><list-item id="u0145"><p>Visual agnosia</p></list-item><list-item id="u0150"><p>Dressing apraxia</p></list-item><list-item id="u0155"><p>Environmental disorientation</p></list-item><list-item id="u0160"><p>Proportionally less impaired deficits in memory and verbal fluency</p></list-item><list-item id="u0165"><p>Relatively preserved insight with or without depression</p></list-item></list></p></list-item><list-item id="u0170"><p>Supportive diagnostic features<list list-type="simple"><list-item id="u0175"><p>Presenile onset</p></list-item><list-item id="u0180"><p>Alexia</p></list-item><list-item id="u0185"><p>Elements of Gerstmann's syndrome</p></list-item><list-item id="u0190"><p>Ideomotor apraxia</p></list-item><list-item id="u0195"><p>Physical examination within normal limits</p></list-item></list></p></list-item><list-item id="u0200"><p>Investigations<list list-type="simple"><list-item id="u0205"><p>Neuropsychology: predominantly impaired perceptual deficits</p></list-item><list-item id="u0210"><p>Brain imaging: predominantly occipitoparietal abnormality (especially on functional neuroimaging) with relative sparing of frontal and mesiotemporal regions.</p></list-item></list></p></list-item></list></td></tr></tbody></table></table-wrap><table-wrap id="tbl2" position="float"><label>Table 2</label><caption><p>Clinical features and demographics</p></caption><table frame="hsides" rules="groups"><tbody><tr><td>Total number of DNA samples received</td><td>302</td></tr><tr><td>Number (%) male</td><td align="char">124 (41%)</td></tr><tr><td>Mean ± SD age at onset (y)</td><td>58.9 ± 6.9</td></tr><tr><td>Number (%) with young onset dementia (onset <65 y)</td><td align="char">249 (83%)</td></tr><tr><td>Number with biomarker/path evidence for AD<xref rid="tbl2fnlowast" ref-type="table-fn">∗</xref></td><td align="char">82 (27%)</td></tr><tr><td>Number (%) with known age of death</td><td>34</td></tr><tr><td>Mean ± SD age at death (y)</td><td>67.9 ± 7.7</td></tr><tr><td colspan="2"><inline-graphic xlink:href="fx1.gif"></inline-graphic><break></break>9 samples failed genetic QC<break></break><inline-graphic xlink:href="fx1.gif"></inline-graphic></td></tr><tr><td>Total number of DNA samples passing QC and entering analysis</td><td>293</td></tr><tr><td>Number (%) male</td><td align="char">120 (41%)</td></tr><tr><td>Mean ± SD age at onset (y)</td><td>58.8 ± 6.9</td></tr><tr><td>Number (%) with young onset dementia (onset <65 y)</td><td align="char">243 (83%)</td></tr><tr><td>Number with biomarker/path evidence for AD<xref rid="tbl2fnlowast" ref-type="table-fn">∗</xref></td><td align="char">77 (26%)</td></tr><tr><td>Number (%) with known age of death</td><td>33</td></tr><tr><td>Mean ± SD age at death (y)</td><td>67.8 ± 7.8</td></tr></tbody></table><table-wrap-foot><fn id="tbl2fnlowast"><label>∗</label><p id="ntpara0010">No individual with biomarker/path evidence for a non-AD diagnosis was included.</p></fn></table-wrap-foot></table-wrap><table-wrap id="tbl3" position="float"><label>Table 3</label><caption><p>Results of the main analysis for candidate SNPs which were discovered in typical AD (ref <xref rid="bib16" ref-type="bibr">[16]</xref>, except <sup>∗</sup>Seshadri et al. JAMA 2010:303; 1832–40, <sup>†</sup>Hollingworth et al. Nat Genet 2011:43:429–35) or DLB <xref rid="bib17" ref-type="bibr">[17]</xref></p></caption><table frame="hsides" rules="groups"><thead><tr><th>Candidate SNP</th><th>Chr</th><th>Nearest gene</th><th>Typical AD/DLB OR</th><th>PCA vs control <italic>P</italic> value</th><th>PCA OR</th><th>PCA OR CI</th><th><italic>P</italic> Value for comparison of OR (PCA vs typical AD)</th><th>Cases MAF</th><th>Control MAF</th></tr></thead><tbody><tr><td>rs3818361</td><td align="char">1</td><td><italic>CR1</italic></td><td align="char">1.17</td><td>6.71E−04</td><td align="char">1.38</td><td align="char">(1.14–1.67)</td><td align="char">.09</td><td align="char">0.24</td><td align="char">0.19</td></tr><tr><td>rs744373</td><td align="char">2</td><td><italic>BIN1</italic></td><td align="char">1.17</td><td align="char">0.04</td><td align="char">1.20</td><td align="char">(1.01–1.43)</td><td align="char">.77</td><td align="char">0.32</td><td align="char">0.28</td></tr><tr><td>rs35349669</td><td align="char">2</td><td><italic>INPP5D</italic></td><td align="char">1.08</td><td align="char">0.21</td><td align="char">0.89</td><td align="char">(0.75–1.04)</td><td align="char">.02</td><td align="char">0.46</td><td align="char">0.49</td></tr><tr><td>rs6825004</td><td align="char">4</td><td><italic>SCARB2</italic></td><td align="char">0.78</td><td align="char">0.42</td><td align="char">0.92</td><td align="char">(0.77–1.1)</td><td align="char">.38</td><td align="char">0.29</td><td align="char">0.31</td></tr><tr><td>rs7687945</td><td align="char">4</td><td><italic>SNCA</italic></td><td align="char">0.75</td><td align="char">0.92</td><td align="char">1.00</td><td align="char">(0.85–1.18)</td><td align="char">.08</td><td align="char">0.49</td><td align="char">0.49</td></tr><tr><td>rs190982</td><td align="char">5</td><td><italic>MEF2C</italic></td><td align="char">0.93</td><td align="char">0.66</td><td align="char">0.99</td><td align="char">(0.83–1.18)</td><td align="char">.50</td><td align="char">0.40</td><td align="char">0.40</td></tr><tr><td>rs10948363</td><td align="char">6</td><td><italic>CD2AP</italic></td><td align="char">1.10</td><td align="char">0.67</td><td align="char">0.97</td><td align="char">(0.8–1.17)</td><td align="char">.19</td><td align="char">0.27</td><td align="char">0.27</td></tr><tr><td>rs11767557</td><td align="char">7</td><td><italic>EPHA1</italic></td><td align="char">0.90</td><td align="char">0.39</td><td align="char">0.92</td><td align="char">(0.74–1.13)</td><td align="char">.73</td><td align="char">0.19</td><td align="char">0.20</td></tr><tr><td>rs2718058</td><td align="char">7</td><td><italic>NME8</italic></td><td align="char">0.93</td><td align="char">0.17</td><td align="char">1.12</td><td align="char">(0.95–1.33)</td><td align="char">.03</td><td align="char">0.39</td><td align="char">0.36</td></tr><tr><td>rs1476679</td><td align="char">7</td><td><italic>ZCWPW1</italic></td><td align="char">0.91</td><td align="char">0.73</td><td align="char">1.05</td><td align="char">(0.88–1.25)</td><td align="char">.12</td><td align="char">0.31</td><td align="char">0.30</td></tr><tr><td>rs11136000</td><td align="char">8</td><td><italic>CLU</italic></td><td align="char">0.87</td><td align="char">0.27</td><td align="char">0.91</td><td align="char">(0.77–1.09)</td><td align="char">.58</td><td align="char">0.37</td><td align="char">0.40</td></tr><tr><td>rs28834970</td><td align="char">8</td><td><italic>PTK2B</italic></td><td align="char">1.10</td><td align="char">0.27</td><td align="char">1.10</td><td align="char">(0.93–1.3)</td><td align="char">.98</td><td align="char">0.37</td><td align="char">0.35</td></tr><tr><td>rs10838725</td><td align="char">11</td><td><italic>CELF1</italic></td><td align="char">1.08</td><td align="char">0.98</td><td align="char">1.01</td><td align="char">(0.84–1.2)</td><td align="char">.45</td><td align="char">0.32</td><td align="char">0.31</td></tr><tr><td>rs670139<sup>†</sup></td><td align="char">11</td><td><italic>MS4A4E</italic></td><td align="char">1.08</td><td align="char">0.77</td><td align="char">0.97</td><td align="char">(0.82–1.14)</td><td align="char">.19</td><td align="char">0.40</td><td align="char">0.41</td></tr><tr><td>rs983392</td><td align="char">11</td><td><italic>MS4A6A</italic></td><td align="char">0.90</td><td align="char">0.71</td><td align="char">1.04</td><td align="char">(0.88–1.22)</td><td align="char">.09</td><td align="char">0.42</td><td align="char">0.41</td></tr><tr><td>rs3851179</td><td align="char">11</td><td><italic>PICALM</italic></td><td align="char">0.87</td><td align="char">0.39</td><td align="char">0.94</td><td align="char">(0.79–1.11)</td><td align="char">.40</td><td align="char">0.35</td><td align="char">0.37</td></tr><tr><td>rs11218343</td><td align="char">11</td><td><italic>SORL1</italic></td><td align="char">0.77</td><td align="char">0.57</td><td align="char">0.81</td><td align="char">(0.4–1.65)</td><td align="char">.88</td><td align="char">0.01</td><td align="char">0.02</td></tr><tr><td>rs17125944</td><td align="char">14</td><td><italic>FERMT2</italic></td><td align="char">1.14</td><td align="char">0.73</td><td align="char">0.94</td><td align="char">(0.7–1.27)</td><td align="char">.21</td><td align="char">0.08</td><td align="char">0.09</td></tr><tr><td>rs10498633</td><td align="char">14</td><td><italic>SLC24A4</italic><break></break><italic>RIN3</italic></td><td align="char">0.91</td><td align="char">0.14</td><td align="char">0.86</td><td align="char">(0.7–1.06)</td><td align="char">.62</td><td align="char">0.20</td><td align="char">0.23</td></tr><tr><td>rs3764650</td><td align="char">19</td><td><italic>ABCA7</italic></td><td align="char">1.20</td><td align="char">0.02</td><td align="char">1.39</td><td align="char">(1.07–1.8)</td><td align="char">.28</td><td align="char">0.12</td><td align="char">0.09</td></tr><tr><td>rs2075650</td><td align="char">19</td><td><italic>APOE</italic></td><td align="char">2.83</td><td>6.24E−14</td><td align="char">2.03</td><td align="char">(1.68–2.46)</td><td align="char">.0007</td><td align="char">0.25</td><td align="char">0.14</td></tr><tr><td>rs3865444<sup>†</sup></td><td align="char">19</td><td><italic>CD33</italic></td><td align="char">0.91</td><td align="char">0.69</td><td align="char">0.95</td><td align="char">(0.8–1.14)</td><td align="char">.61</td><td align="char">0.30</td><td align="char">0.31</td></tr><tr><td>rs597668<sup>∗</sup></td><td align="char">19</td><td><italic>EXOC3L2</italic><break></break><italic>BLOC1S3</italic><break></break><italic>MARK4</italic></td><td align="char">1.18</td><td align="char">0.59</td><td align="char">1.04</td><td align="char">(0.84–1.3)</td><td align="char">.30</td><td align="char">0.17</td><td align="char">0.16</td></tr><tr><td>rs7274581</td><td align="char">20</td><td><italic>CASS4</italic></td><td align="char">0.88</td><td align="char">0.52</td><td align="char">1.12</td><td align="char">(0.85–1.48)</td><td align="char">.09</td><td align="char">0.10</td><td align="char">0.09</td></tr></tbody></table><table-wrap-foot><fn><p>OR, odds ratio; MAF, minor allele frequency; CI, confidence interval.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease
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| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
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