Association between osteocalcin and cognitive performance in healthy older adults
Identifieur interne : 002072 ( Pmc/Curation ); précédent : 002071; suivant : 002073Association between osteocalcin and cognitive performance in healthy older adults
Auteurs : Steven Bradburn [Royaume-Uni] ; Jamie S. Mcphee [Royaume-Uni] ; Liam Bagley [Royaume-Uni] ; Sarianna Sipila [Finlande] ; Lauri Stenroth [Finlande] ; Marco Vincenzo Narici [Royaume-Uni] ; Mati P Suke [Estonie] ; Helena Gapeyeva [Estonie] ; Gabrielle Osborne [Royaume-Uni] ; Lorraine Sassano [Royaume-Uni] ; Carel G. M. Meskers [Pays-Bas] ; Andrea B. Maier [Pays-Bas, Australie] ; Jean-Yves Hogrel [France] ; Yoann Barnouin [France] ; Gillian Butler-Browne [France] ; Chris Murgatroyd [Royaume-Uni]Source :
- Age and Ageing [ 0002-0729 ] ; 2016.
Abstract
cognitive deterioration and reductions of bone health coincide with increasing age. We examine the relationship between bone composition and plasma markers of bone remodelling with measures of cognitive performance in healthy adults.
this cross-sectional study included 225 old (52% women, mean age: 74.4 ± 3.3 years) and 134 young (52% women, mean age: 23.4 ± 2.7 years) adult participants from the MyoAge project. Whole body bone mineral density was measured by dual-energy X-ray absorptiometry. Blood analyses included a panel of bone-related peptides (dickkopf-1, osteoprotegerin, osteocalcin (OC), osteopontin, sclerostin, parathyroid hormone and fibroblast growth factor 23), as well as serum calcium and 25-hydroxy vitamin D assays. A selection of cognitive domains (working memory capacity, episodic memory, executive functioning and global cognition) was assessed with a standardised neuropsychological test battery.
adjusting for covariates and multiple testing revealed that plasma OC levels were positively associated with measures of executive functioning (
these correlative results demonstrate a positive association between OC, a factor known to regulate bone remodelling, with cognitive performance in older non-demented women. Further work should address possible mechanistic interpretations in humans.
Url:
DOI: 10.1093/ageing/afw137
PubMed: 27515675
PubMed Central: 5105824
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Mcphee</name><affiliation wicri:level="1"><nlm:aff id="afw137af1"><institution>Manchester Metropolitan University,</institution><addr-line> School of Healthcare Science, Manchester</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bagley, Liam" sort="Bagley, Liam" uniqKey="Bagley L" first="Liam" last="Bagley">Liam Bagley</name><affiliation wicri:level="1"><nlm:aff id="afw137af1"><institution>Manchester Metropolitan University,</institution><addr-line> School of Healthcare Science, Manchester</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sipila, Sarianna" sort="Sipila, Sarianna" uniqKey="Sipila S" first="Sarianna" last="Sipila">Sarianna Sipila</name><affiliation wicri:level="1"><nlm:aff id="afw137af2"><institution>University of Jyväskylä</institution>,<addr-line>Gerontology Research Centre, Health Sciences, 40630 Jyväskylä</addr-line>,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stenroth, Lauri" sort="Stenroth, Lauri" uniqKey="Stenroth L" first="Lauri" last="Stenroth">Lauri Stenroth</name><affiliation wicri:level="1"><nlm:aff id="afw137af2"><institution>University of Jyväskylä</institution>,<addr-line>Gerontology Research Centre, Health Sciences, 40630 Jyväskylä</addr-line>,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Narici, Marco Vincenzo" sort="Narici, Marco Vincenzo" uniqKey="Narici M" first="Marco Vincenzo" last="Narici">Marco Vincenzo Narici</name><affiliation wicri:level="1"><nlm:aff id="afw137af3"><institution>University of Nottingham</institution>,<addr-line>Faculty of Medicine and Health Sciences, Derby</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="P Suke, Mati" sort="P Suke, Mati" uniqKey="P Suke M" first="Mati" last="P Suke">Mati P Suke</name><affiliation wicri:level="1"><nlm:aff id="afw137af4"><institution>University of Tartu</institution>,<addr-line>Institute of Exercise Biology and Physiotherapy, Tartu</addr-line>,<country>Estonia</country></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gapeyeva, Helena" sort="Gapeyeva, Helena" uniqKey="Gapeyeva H" first="Helena" last="Gapeyeva">Helena Gapeyeva</name><affiliation wicri:level="1"><nlm:aff id="afw137af4"><institution>University of Tartu</institution>,<addr-line>Institute of Exercise Biology and Physiotherapy, Tartu</addr-line>,<country>Estonia</country></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Osborne, Gabrielle" sort="Osborne, Gabrielle" uniqKey="Osborne G" first="Gabrielle" last="Osborne">Gabrielle Osborne</name><affiliation wicri:level="1"><nlm:aff id="afw137af5"><addr-line>Unilever Discover, Colworth Park, Sharnbrook, Bedford</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sassano, Lorraine" sort="Sassano, Lorraine" uniqKey="Sassano L" first="Lorraine" last="Sassano">Lorraine Sassano</name><affiliation wicri:level="1"><nlm:aff id="afw137af5"><addr-line>Unilever Discover, Colworth Park, Sharnbrook, Bedford</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Meskers, Carel G M" sort="Meskers, Carel G M" uniqKey="Meskers C" first="Carel G. M." last="Meskers">Carel G. M. Meskers</name><affiliation wicri:level="1"><nlm:aff id="afw137af6"><institution>VU University Medical Center</institution>,<addr-line>Rehabilitation Medicine</addr-line>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Maier, Andrea B" sort="Maier, Andrea B" uniqKey="Maier A" first="Andrea B." last="Maier">Andrea B. 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Mcphee</name><affiliation wicri:level="1"><nlm:aff id="afw137af1"><institution>Manchester Metropolitan University,</institution><addr-line> School of Healthcare Science, Manchester</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bagley, Liam" sort="Bagley, Liam" uniqKey="Bagley L" first="Liam" last="Bagley">Liam Bagley</name><affiliation wicri:level="1"><nlm:aff id="afw137af1"><institution>Manchester Metropolitan University,</institution><addr-line> School of Healthcare Science, Manchester</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sipila, Sarianna" sort="Sipila, Sarianna" uniqKey="Sipila S" first="Sarianna" last="Sipila">Sarianna Sipila</name><affiliation wicri:level="1"><nlm:aff id="afw137af2"><institution>University of Jyväskylä</institution>,<addr-line>Gerontology Research Centre, Health Sciences, 40630 Jyväskylä</addr-line>,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stenroth, Lauri" sort="Stenroth, Lauri" uniqKey="Stenroth L" first="Lauri" last="Stenroth">Lauri Stenroth</name><affiliation wicri:level="1"><nlm:aff id="afw137af2"><institution>University of Jyväskylä</institution>,<addr-line>Gerontology Research Centre, Health Sciences, 40630 Jyväskylä</addr-line>,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Narici, Marco Vincenzo" sort="Narici, Marco Vincenzo" uniqKey="Narici M" first="Marco Vincenzo" last="Narici">Marco Vincenzo Narici</name><affiliation wicri:level="1"><nlm:aff id="afw137af3"><institution>University of Nottingham</institution>,<addr-line>Faculty of Medicine and Health Sciences, Derby</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="P Suke, Mati" sort="P Suke, Mati" uniqKey="P Suke M" first="Mati" last="P Suke">Mati P Suke</name><affiliation wicri:level="1"><nlm:aff id="afw137af4"><institution>University of Tartu</institution>,<addr-line>Institute of Exercise Biology and Physiotherapy, Tartu</addr-line>,<country>Estonia</country></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gapeyeva, Helena" sort="Gapeyeva, Helena" uniqKey="Gapeyeva H" first="Helena" last="Gapeyeva">Helena Gapeyeva</name><affiliation wicri:level="1"><nlm:aff id="afw137af4"><institution>University of Tartu</institution>,<addr-line>Institute of Exercise Biology and Physiotherapy, Tartu</addr-line>,<country>Estonia</country></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Osborne, Gabrielle" sort="Osborne, Gabrielle" uniqKey="Osborne G" first="Gabrielle" last="Osborne">Gabrielle Osborne</name><affiliation wicri:level="1"><nlm:aff id="afw137af5"><addr-line>Unilever Discover, Colworth Park, Sharnbrook, Bedford</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sassano, Lorraine" sort="Sassano, Lorraine" uniqKey="Sassano L" first="Lorraine" last="Sassano">Lorraine Sassano</name><affiliation wicri:level="1"><nlm:aff id="afw137af5"><addr-line>Unilever Discover, Colworth Park, Sharnbrook, Bedford</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Meskers, Carel G M" sort="Meskers, Carel G M" uniqKey="Meskers C" first="Carel G. M." last="Meskers">Carel G. M. Meskers</name><affiliation wicri:level="1"><nlm:aff id="afw137af6"><institution>VU University Medical Center</institution>,<addr-line>Rehabilitation Medicine</addr-line>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Maier, Andrea B" sort="Maier, Andrea B" uniqKey="Maier A" first="Andrea B." last="Maier">Andrea B. Maier</name><affiliation wicri:level="1"><nlm:aff id="afw137af7"><institution>VU University Medical Center</institution>,<addr-line>Faculty of Human Movement Sciences</addr-line>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="afw137af8"><addr-line>Royal Melbourne Hospital</addr-line>,<institution>University of Melbourne</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hogrel, Jean Yves" sort="Hogrel, Jean Yves" uniqKey="Hogrel J" first="Jean-Yves" last="Hogrel">Jean-Yves Hogrel</name><affiliation wicri:level="1"><nlm:aff id="afw137af9"><addr-line>Institut de Myologie, 75634 Paris Cedex 13,</addr-line><country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Barnouin, Yoann" sort="Barnouin, Yoann" uniqKey="Barnouin Y" first="Yoann" last="Barnouin">Yoann Barnouin</name><affiliation wicri:level="1"><nlm:aff id="afw137af9"><addr-line>Institut de Myologie, 75634 Paris Cedex 13,</addr-line><country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Butler Browne, Gillian" sort="Butler Browne, Gillian" uniqKey="Butler Browne G" first="Gillian" last="Butler-Browne">Gillian Butler-Browne</name><affiliation wicri:level="1"><nlm:aff id="afw137af9"><addr-line>Institut de Myologie, 75634 Paris Cedex 13,</addr-line><country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Murgatroyd, Chris" sort="Murgatroyd, Chris" uniqKey="Murgatroyd C" first="Chris" last="Murgatroyd">Chris Murgatroyd</name><affiliation wicri:level="1"><nlm:aff id="afw137af1"><institution>Manchester Metropolitan University,</institution><addr-line> School of Healthcare Science, Manchester</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Age and Ageing</title><idno type="ISSN">0002-0729</idno><idno type="eISSN">1468-2834</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="afw137s1" sec-type="intro"><title>Introduction</title><p>cognitive deterioration and reductions of bone health coincide with increasing age. We examine the relationship between bone composition and plasma markers of bone remodelling with measures of cognitive performance in healthy adults.</p></sec><sec id="afw137s2" sec-type="methods"><title>Methods</title><p>this cross-sectional study included 225 old (52% women, mean age: 74.4 ± 3.3 years) and 134 young (52% women, mean age: 23.4 ± 2.7 years) adult participants from the MyoAge project. Whole body bone mineral density was measured by dual-energy X-ray absorptiometry. Blood analyses included a panel of bone-related peptides (dickkopf-1, osteoprotegerin, osteocalcin (OC), osteopontin, sclerostin, parathyroid hormone and fibroblast growth factor 23), as well as serum calcium and 25-hydroxy vitamin D assays. A selection of cognitive domains (working memory capacity, episodic memory, executive functioning and global cognition) was assessed with a standardised neuropsychological test battery.</p></sec><sec id="afw137s3" sec-type="results"><title>Results</title><p>adjusting for covariates and multiple testing revealed that plasma OC levels were positively associated with measures of executive functioning (<italic>β</italic> = 0.444, <italic>P</italic> < 0.001) and global cognition (<italic>β</italic> = 0.381, <italic>P</italic> = 0.001) in the older women.</p></sec><sec id="afw137s4" sec-type="discussion"><title>Discussion</title><p>these correlative results demonstrate a positive association between OC, a factor known to regulate bone remodelling, with cognitive performance in older non-demented women. Further work should address possible mechanistic interpretations in humans.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zhou, R" uniqKey="Zhou R">R Zhou</name></author><author><name sortKey="Deng, J" uniqKey="Deng J">J Deng</name></author><author><name sortKey="Zhang, M" uniqKey="Zhang M">M Zhang</name></author><author><name sortKey="Zhou, H D" uniqKey="Zhou H">H-D Zhou</name></author><author><name sortKey="Wang, Y J" uniqKey="Wang Y">Y-J Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sohrabi, Hr" uniqKey="Sohrabi H">HR Sohrabi</name></author><author><name sortKey="Bates, Ka" uniqKey="Bates K">KA Bates</name></author><author><name sortKey="Weinborn, M" uniqKey="Weinborn M">M Weinborn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raggatt, Lj" uniqKey="Raggatt L">LJ Raggatt</name></author><author><name sortKey="Partridge, Nc" uniqKey="Partridge 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Age Ageing</journal-id><journal-id journal-id-type="iso-abbrev">Age Ageing</journal-id><journal-id journal-id-type="publisher-id">ageing</journal-id><journal-id journal-id-type="hwp">ageing</journal-id><journal-title-group><journal-title>Age and Ageing</journal-title></journal-title-group><issn pub-type="ppub">0002-0729</issn><issn pub-type="epub">1468-2834</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27515675</article-id><article-id pub-id-type="pmc">5105824</article-id><article-id pub-id-type="doi">10.1093/ageing/afw137</article-id><article-id pub-id-type="publisher-id">afw137</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Paper</subject></subj-group></article-categories><title-group><article-title>Association between osteocalcin and cognitive performance in healthy older adults</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Bradburn</surname><given-names>Steven</given-names></name><xref ref-type="aff" rid="afw137af1">1</xref></contrib><contrib contrib-type="author"><name><surname>McPhee</surname><given-names>Jamie S</given-names></name><xref ref-type="aff" rid="afw137af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Bagley</surname><given-names>Liam</given-names></name><xref ref-type="aff" rid="afw137af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Sipila</surname><given-names>Sarianna</given-names></name><xref ref-type="aff" rid="afw137af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Stenroth</surname><given-names>Lauri</given-names></name><xref ref-type="aff" rid="afw137af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Narici</surname><given-names>Marco Vincenzo</given-names></name><xref ref-type="aff" rid="afw137af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Pääsuke</surname><given-names>Mati</given-names></name><xref ref-type="aff" rid="afw137af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Gapeyeva</surname><given-names>Helena</given-names></name><xref ref-type="aff" rid="afw137af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Osborne</surname><given-names>Gabrielle</given-names></name><xref ref-type="aff" rid="afw137af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Sassano</surname><given-names>Lorraine</given-names></name><xref ref-type="aff" rid="afw137af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Meskers</surname><given-names>Carel G. M.</given-names></name><xref ref-type="aff" rid="afw137af6">6</xref></contrib><contrib contrib-type="author"><name><surname>Maier</surname><given-names>Andrea B.</given-names></name><xref ref-type="aff" rid="afw137af7">7</xref><xref ref-type="aff" rid="afw137af8">8</xref></contrib><contrib contrib-type="author"><name><surname>Hogrel</surname><given-names>Jean-Yves</given-names></name><xref ref-type="aff" rid="afw137af9">9</xref></contrib><contrib contrib-type="author"><name><surname>Barnouin</surname><given-names>Yoann</given-names></name><xref ref-type="aff" rid="afw137af9">9</xref></contrib><contrib contrib-type="author"><name><surname>Butler-Browne</surname><given-names>Gillian</given-names></name><xref ref-type="aff" rid="afw137af9">9</xref></contrib><contrib contrib-type="author"><name><surname>Murgatroyd</surname><given-names>Chris</given-names></name><xref ref-type="aff" rid="afw137af1">1</xref></contrib><aff id="afw137af1"><label>1</label><institution>Manchester Metropolitan University,</institution><addr-line> School of Healthcare Science, Manchester</addr-line>,<country>UK</country></aff><aff id="afw137af2"><label>2</label><institution>University of Jyväskylä</institution>,<addr-line>Gerontology Research Centre, Health Sciences, 40630 Jyväskylä</addr-line>,<country>Finland</country></aff><aff id="afw137af3"><label>3</label><institution>University of Nottingham</institution>,<addr-line>Faculty of Medicine and Health Sciences, Derby</addr-line>,<country>UK</country></aff><aff id="afw137af4"><label>4</label><institution>University of Tartu</institution>,<addr-line>Institute of Exercise Biology and Physiotherapy, Tartu</addr-line>,<country>Estonia</country></aff><aff id="afw137af5"><label>5</label><addr-line>Unilever Discover, Colworth Park, Sharnbrook, Bedford</addr-line>,<country>UK</country></aff><aff id="afw137af6"><label>6</label><institution>VU University Medical Center</institution>,<addr-line>Rehabilitation Medicine</addr-line>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country></aff><aff id="afw137af7"><label>7</label><institution>VU University Medical Center</institution>,<addr-line>Faculty of Human Movement Sciences</addr-line>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country></aff><aff id="afw137af8"><label>8</label><addr-line>Royal Melbourne Hospital</addr-line>,<institution>University of Melbourne</institution>,<addr-line>Melbourne</addr-line>,<country>Australia</country></aff><aff id="afw137af9"><label>9</label><addr-line>Institut de Myologie, 75634 Paris Cedex 13,</addr-line><country>France</country></aff></contrib-group><author-notes><corresp id="afw137cor1">Address correspondence to: C. Murgatroyd. Email: <email>c.murgatroyd@mmu.ac.uk</email></corresp></author-notes><pub-date pub-type="ppub"><month>11</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>02</day><month>11</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>02</day><month>11</month><year>2016</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>45</volume><issue>6</issue><fpage>844</fpage><lpage>849</lpage><history><date date-type="received"><day>5</day><month>2</month><year>2016</year></date><date date-type="accepted"><day>23</day><month>5</month><year>2016</year></date></history><permissions><copyright-statement>© The Author 2016. Published by Oxford University Press on behalf of the British Geriatrics Society.</copyright-statement><copyright-year>2016</copyright-year><license license-type="creative-commons" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</ext-link>), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com</license-p></license></permissions><self-uri content-type="pdf" xlink:href="afw137.pdf"></self-uri><abstract><sec id="afw137s1" sec-type="intro"><title>Introduction</title><p>cognitive deterioration and reductions of bone health coincide with increasing age. We examine the relationship between bone composition and plasma markers of bone remodelling with measures of cognitive performance in healthy adults.</p></sec><sec id="afw137s2" sec-type="methods"><title>Methods</title><p>this cross-sectional study included 225 old (52% women, mean age: 74.4 ± 3.3 years) and 134 young (52% women, mean age: 23.4 ± 2.7 years) adult participants from the MyoAge project. Whole body bone mineral density was measured by dual-energy X-ray absorptiometry. Blood analyses included a panel of bone-related peptides (dickkopf-1, osteoprotegerin, osteocalcin (OC), osteopontin, sclerostin, parathyroid hormone and fibroblast growth factor 23), as well as serum calcium and 25-hydroxy vitamin D assays. A selection of cognitive domains (working memory capacity, episodic memory, executive functioning and global cognition) was assessed with a standardised neuropsychological test battery.</p></sec><sec id="afw137s3" sec-type="results"><title>Results</title><p>adjusting for covariates and multiple testing revealed that plasma OC levels were positively associated with measures of executive functioning (<italic>β</italic> = 0.444, <italic>P</italic> < 0.001) and global cognition (<italic>β</italic> = 0.381, <italic>P</italic> = 0.001) in the older women.</p></sec><sec id="afw137s4" sec-type="discussion"><title>Discussion</title><p>these correlative results demonstrate a positive association between OC, a factor known to regulate bone remodelling, with cognitive performance in older non-demented women. Further work should address possible mechanistic interpretations in humans.</p></sec></abstract><kwd-group><kwd>older people</kwd><kwd>cognitive decline</kwd><kwd>ageing</kwd><kwd>osteocalcin</kwd></kwd-group><funding-group><award-group id="afw137funding-1"><funding-source><institution-wrap><institution>European Union FP7</institution></institution-wrap></funding-source><award-id>223576</award-id></award-group></funding-group><counts><page-count count="6"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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