Integrative genome analyses identify key somatic driver mutations of small cell lung cancer
Identifieur interne : 001F88 ( Pmc/Curation ); précédent : 001F87; suivant : 001F89Integrative genome analyses identify key somatic driver mutations of small cell lung cancer
Auteurs : Martin Peifer [Allemagne] ; Lynnette Fernández-Cuesta [Allemagne] ; Martin L. Sos [Allemagne] ; Julie George [Allemagne] ; Danila Seidel [Allemagne] ; Lawryn H. Kasper [États-Unis] ; Dennis Plenker [Allemagne] ; Frauke Leenders [Allemagne] ; Ruping Sun [Allemagne] ; Thomas Zander [Allemagne] ; Roopika Menon [Allemagne] ; Mirjam Koker [Allemagne] ; Ilona Dahmen [Allemagne] ; Christian Müller [Allemagne] ; Vincenzo Di Cerbo [Allemagne] ; Hans-Ulrich Schildhaus [Allemagne] ; Janine Altmüller [Allemagne] ; Ingelore Baessmann [Allemagne] ; Christian Becker [Allemagne] ; Bram De Wilde [Belgique] ; Jo Vandesompele [Belgique] ; Diana Böhm [Allemagne] ; Sascha Ansén [Allemagne] ; Franziska Gabler [Allemagne] ; Ines Wilkening [Allemagne] ; Stefanie Heynck [Allemagne] ; Johannes M. Heuckmann [Allemagne] ; Xin Lu [Allemagne] ; Scott L. Carter [États-Unis] ; Kristian Cibulskis [États-Unis] ; Shantanu Banerji [États-Unis] ; Gad Getz [États-Unis] ; Kwon-Sik Park [États-Unis] ; Daniel Rauh [Allemagne] ; Christian Grütter [Allemagne] ; Matthias Fischer [Allemagne] ; Laura Pasqualucci [États-Unis] ; Gavin Wright [Australie] ; Zoe Wainer [Australie] ; Prudence Russell [Australie] ; Iver Petersen [Allemagne] ; Yuan Chen [Allemagne] ; Erich Stoelben [Allemagne] ; Corinna Ludwig [Allemagne] ; Philipp Schnabel [Allemagne] ; Hans Hoffmann [Allemagne] ; Thomas Muley [Allemagne] ; Michael Brockmann [Allemagne] ; Walburga Engel-Riedel [Allemagne] ; Lucia A. Muscarella [Italie] ; Vito M. Fazio [Italie] ; Harry Groen [Pays-Bas] ; Wim Timens [Pays-Bas] ; Hannie Sietsma [Pays-Bas] ; Erik Thunnissen [Pays-Bas] ; Egbert Smit [Pays-Bas] ; Daniëlle Am Heideman [Pays-Bas] ; Peter Jf Snijders [Pays-Bas] ; Federico Cappuzzo [Italie] ; Claudia Ligorio [Italie] ; Stefania Damiani [Italie] ; John Field [Royaume-Uni] ; Steinar Solberg [Norvège] ; Odd Terje Brustugun [Norvège] ; Marius Lund-Iversen [Norvège] ; Jörg S Nger [Allemagne] ; Joachim H. Clement [Allemagne] ; Alex Soltermann [Suisse] ; Holger Moch [Suisse] ; Walter Weder [Suisse] ; Benjamin Solomon [Australie] ; Jean-Charles Soria [France] ; Pierre Validire [France] ; Benjamin Besse [France] ; Elisabeth Brambilla [France] ; Christian Brambilla [France] ; Sylvie Lantuejoul [France] ; Philippe Lorimier [France] ; Peter M. Schneider [Allemagne] ; Michael Hallek [Allemagne] ; William Pao [États-Unis] ; Matthew Meyerson [États-Unis] ; Julien Sage [États-Unis] ; Jay Shendure [États-Unis] ; Robert Schneider [Allemagne, France] ; Reinhard Büttner [Allemagne] ; Jürgen Wolf [Allemagne] ; Peter Nürnberg [Allemagne] ; Sven Perner [Allemagne] ; Lukas C. Heukamp [Allemagne] ; Paul K. Brindle [États-Unis] ; Stefan Haas [Allemagne] ; Roman K. Thomas [Allemagne]Source :
- Nature genetics [ 1061-4036 ] ; 2012.
Abstract
Small-cell lung cancer (SCLC) is an aggressive lung tumor subtype with poor survival
Url:
DOI: 10.1038/ng.2396
PubMed: 22941188
PubMed Central: 4915822
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</affiliation>
</author>
<author><name sortKey="Heuckmann, Johannes M" sort="Heuckmann, Johannes M" uniqKey="Heuckmann J" first="Johannes M" last="Heuckmann">Johannes M. Heuckmann</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lu, Xin" sort="Lu, Xin" uniqKey="Lu X" first="Xin" last="Lu">Xin Lu</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Carter, Scott L" sort="Carter, Scott L" uniqKey="Carter S" first="Scott L" last="Carter">Scott L. Carter</name>
<affiliation wicri:level="1"><nlm:aff id="A12">The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cibulskis, Kristian" sort="Cibulskis, Kristian" uniqKey="Cibulskis K" first="Kristian" last="Cibulskis">Kristian Cibulskis</name>
<affiliation wicri:level="1"><nlm:aff id="A12">The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Banerji, Shantanu" sort="Banerji, Shantanu" uniqKey="Banerji S" first="Shantanu" last="Banerji">Shantanu Banerji</name>
<affiliation wicri:level="1"><nlm:aff id="A12">The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Getz, Gad" sort="Getz, Gad" uniqKey="Getz G" first="Gad" last="Getz">Gad Getz</name>
<affiliation wicri:level="1"><nlm:aff id="A12">The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Park, Kwon Sik" sort="Park, Kwon Sik" uniqKey="Park K" first="Kwon-Sik" last="Park">Kwon-Sik Park</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Department of Pediatrics, Stanford University, Stanford, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, Stanford University, Stanford, California</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A14">Department of Genetics, Stanford University, Stanford, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, Stanford University, Stanford, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rauh, Daniel" sort="Rauh, Daniel" uniqKey="Rauh D" first="Daniel" last="Rauh">Daniel Rauh</name>
<affiliation wicri:level="1"><nlm:aff id="A15">Technical University Dortmund, Department of Chemical Biology, Otto-Hahn-Str. 6, 44227 Dortmund, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Technical University Dortmund, Department of Chemical Biology, Otto-Hahn-Str. 6, 44227 Dortmund</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Grutter, Christian" sort="Grutter, Christian" uniqKey="Grutter C" first="Christian" last="Grütter">Christian Grütter</name>
<affiliation wicri:level="1"><nlm:aff id="A15">Technical University Dortmund, Department of Chemical Biology, Otto-Hahn-Str. 6, 44227 Dortmund, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Technical University Dortmund, Department of Chemical Biology, Otto-Hahn-Str. 6, 44227 Dortmund</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fischer, Matthias" sort="Fischer, Matthias" uniqKey="Fischer M" first="Matthias" last="Fischer">Matthias Fischer</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Department of Pediatric Oncology and Hematology, University Children’s Hospital of Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Pediatric Oncology and Hematology, University Children’s Hospital of Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A17">Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pasqualucci, Laura" sort="Pasqualucci, Laura" uniqKey="Pasqualucci L" first="Laura" last="Pasqualucci">Laura Pasqualucci</name>
<affiliation wicri:level="1"><nlm:aff id="A18">Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wright, Gavin" sort="Wright, Gavin" uniqKey="Wright G" first="Gavin" last="Wright">Gavin Wright</name>
<affiliation wicri:level="1"><nlm:aff id="A19">The University of Melbourne Department of Surgery, St Vincent’s Hospital, Level 2, Clinical Sciences Building 29 Regent Street, Melbourne, 3065 Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The University of Melbourne Department of Surgery, St Vincent’s Hospital, Level 2, Clinical Sciences Building 29 Regent Street, Melbourne, 3065 Victoria</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wainer, Zoe" sort="Wainer, Zoe" uniqKey="Wainer Z" first="Zoe" last="Wainer">Zoe Wainer</name>
<affiliation wicri:level="1"><nlm:aff id="A19">The University of Melbourne Department of Surgery, St Vincent’s Hospital, Level 2, Clinical Sciences Building 29 Regent Street, Melbourne, 3065 Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The University of Melbourne Department of Surgery, St Vincent’s Hospital, Level 2, Clinical Sciences Building 29 Regent Street, Melbourne, 3065 Victoria</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Russell, Prudence" sort="Russell, Prudence" uniqKey="Russell P" first="Prudence" last="Russell">Prudence Russell</name>
<affiliation wicri:level="1"><nlm:aff id="A20">Department of Pathology, St. Vincent’s Hospital, Melbourne, 3065 Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Pathology, St. Vincent’s Hospital, Melbourne, 3065 Victoria</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Petersen, Iver" sort="Petersen, Iver" uniqKey="Petersen I" first="Iver" last="Petersen">Iver Petersen</name>
<affiliation wicri:level="1"><nlm:aff id="A21">Institute of Pathology, Jena University Hospital, Friedrich-Schiller-University, 07743 Jena, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Pathology, Jena University Hospital, Friedrich-Schiller-University, 07743 Jena</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chen, Yuan" sort="Chen, Yuan" uniqKey="Chen Y" first="Yuan" last="Chen">Yuan Chen</name>
<affiliation wicri:level="1"><nlm:aff id="A21">Institute of Pathology, Jena University Hospital, Friedrich-Schiller-University, 07743 Jena, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Pathology, Jena University Hospital, Friedrich-Schiller-University, 07743 Jena</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stoelben, Erich" sort="Stoelben, Erich" uniqKey="Stoelben E" first="Erich" last="Stoelben">Erich Stoelben</name>
<affiliation wicri:level="1"><nlm:aff id="A22">Thoracic Surgery, Lungenklinik Merheim, Kliniken der Stadt Köln gGmbH, 51109 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Thoracic Surgery, Lungenklinik Merheim, Kliniken der Stadt Köln gGmbH, 51109 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ludwig, Corinna" sort="Ludwig, Corinna" uniqKey="Ludwig C" first="Corinna" last="Ludwig">Corinna Ludwig</name>
<affiliation wicri:level="1"><nlm:aff id="A22">Thoracic Surgery, Lungenklinik Merheim, Kliniken der Stadt Köln gGmbH, 51109 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Thoracic Surgery, Lungenklinik Merheim, Kliniken der Stadt Köln gGmbH, 51109 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schnabel, Philipp" sort="Schnabel, Philipp" uniqKey="Schnabel P" first="Philipp" last="Schnabel">Philipp Schnabel</name>
<affiliation wicri:level="1"><nlm:aff id="A23">Institute of Pathology, Im Neuenheimer Feld 220, 69120 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Pathology, Im Neuenheimer Feld 220, 69120 Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hoffmann, Hans" sort="Hoffmann, Hans" uniqKey="Hoffmann H" first="Hans" last="Hoffmann">Hans Hoffmann</name>
<affiliation wicri:level="1"><nlm:aff id="A24">Thoraxklinik-Heidelberg gGmbH, Amalienstr. 5, 69126 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Thoraxklinik-Heidelberg gGmbH, Amalienstr. 5, 69126 Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Muley, Thomas" sort="Muley, Thomas" uniqKey="Muley T" first="Thomas" last="Muley">Thomas Muley</name>
<affiliation wicri:level="1"><nlm:aff id="A24">Thoraxklinik-Heidelberg gGmbH, Amalienstr. 5, 69126 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Thoraxklinik-Heidelberg gGmbH, Amalienstr. 5, 69126 Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brockmann, Michael" sort="Brockmann, Michael" uniqKey="Brockmann M" first="Michael" last="Brockmann">Michael Brockmann</name>
<affiliation wicri:level="1"><nlm:aff id="A25">Department of Pathology, Hospital Merheim, Kliniken der Stadt Köln gGmbH, 51109 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Pathology, Hospital Merheim, Kliniken der Stadt Köln gGmbH, 51109 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Engel Riedel, Walburga" sort="Engel Riedel, Walburga" uniqKey="Engel Riedel W" first="Walburga" last="Engel-Riedel">Walburga Engel-Riedel</name>
<affiliation wicri:level="1"><nlm:aff id="A22">Thoracic Surgery, Lungenklinik Merheim, Kliniken der Stadt Köln gGmbH, 51109 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Thoracic Surgery, Lungenklinik Merheim, Kliniken der Stadt Köln gGmbH, 51109 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Muscarella, Lucia A" sort="Muscarella, Lucia A" uniqKey="Muscarella L" first="Lucia A" last="Muscarella">Lucia A. Muscarella</name>
<affiliation wicri:level="1"><nlm:aff id="A26">Laboratory of Oncology, IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini, 71013 San Giovanni Rotondo, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Laboratory of Oncology, IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini, 71013 San Giovanni Rotondo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fazio, Vito M" sort="Fazio, Vito M" uniqKey="Fazio V" first="Vito M" last="Fazio">Vito M. Fazio</name>
<affiliation wicri:level="1"><nlm:aff id="A26">Laboratory of Oncology, IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini, 71013 San Giovanni Rotondo, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Laboratory of Oncology, IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini, 71013 San Giovanni Rotondo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Groen, Harry" sort="Groen, Harry" uniqKey="Groen H" first="Harry" last="Groen">Harry Groen</name>
<affiliation wicri:level="1"><nlm:aff id="A27">Department of Pulmonary Diseases, University Medical Centre Groningen, 9713 GZ Groningen, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Pulmonary Diseases, University Medical Centre Groningen, 9713 GZ Groningen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Timens, Wim" sort="Timens, Wim" uniqKey="Timens W" first="Wim" last="Timens">Wim Timens</name>
<affiliation wicri:level="1"><nlm:aff id="A28">Department of Pathology, University Medical Centre Groningen, 9713 GZ Groningen, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Pathology, University Medical Centre Groningen, 9713 GZ Groningen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sietsma, Hannie" sort="Sietsma, Hannie" uniqKey="Sietsma H" first="Hannie" last="Sietsma">Hannie Sietsma</name>
<affiliation wicri:level="1"><nlm:aff id="A28">Department of Pathology, University Medical Centre Groningen, 9713 GZ Groningen, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Pathology, University Medical Centre Groningen, 9713 GZ Groningen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Thunnissen, Erik" sort="Thunnissen, Erik" uniqKey="Thunnissen E" first="Erik" last="Thunnissen">Erik Thunnissen</name>
<affiliation wicri:level="1"><nlm:aff id="A29">Department of Pathology, VU University Medical Center Amsterdam, 1007 MB Amsterdam, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Pathology, VU University Medical Center Amsterdam, 1007 MB Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Smit, Egbert" sort="Smit, Egbert" uniqKey="Smit E" first="Egbert" last="Smit">Egbert Smit</name>
<affiliation wicri:level="1"><nlm:aff id="A30">Department of Pulmonary Diseases, VU University Medical Center Amsterdam, 1007 MB Amsterdam, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Pulmonary Diseases, VU University Medical Center Amsterdam, 1007 MB Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Heideman, Danielle Am" sort="Heideman, Danielle Am" uniqKey="Heideman D" first="Daniëlle Am" last="Heideman">Daniëlle Am Heideman</name>
<affiliation wicri:level="1"><nlm:aff id="A29">Department of Pathology, VU University Medical Center Amsterdam, 1007 MB Amsterdam, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Pathology, VU University Medical Center Amsterdam, 1007 MB Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Snijders, Peter Jf" sort="Snijders, Peter Jf" uniqKey="Snijders P" first="Peter Jf" last="Snijders">Peter Jf Snijders</name>
<affiliation wicri:level="1"><nlm:aff id="A29">Department of Pathology, VU University Medical Center Amsterdam, 1007 MB Amsterdam, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Pathology, VU University Medical Center Amsterdam, 1007 MB Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cappuzzo, Federico" sort="Cappuzzo, Federico" uniqKey="Cappuzzo F" first="Federico" last="Cappuzzo">Federico Cappuzzo</name>
<affiliation wicri:level="1"><nlm:aff id="A31">Department of Medical Oncology, Ospedale Civile, 57100 Livorno, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medical Oncology, Ospedale Civile, 57100 Livorno</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ligorio, Claudia" sort="Ligorio, Claudia" uniqKey="Ligorio C" first="Claudia" last="Ligorio">Claudia Ligorio</name>
<affiliation wicri:level="1"><nlm:aff id="A32">Department of Haematology and Oncologic Science, University Hospital Bologna, 40138 Bologna, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Haematology and Oncologic Science, University Hospital Bologna, 40138 Bologna</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Damiani, Stefania" sort="Damiani, Stefania" uniqKey="Damiani S" first="Stefania" last="Damiani">Stefania Damiani</name>
<affiliation wicri:level="1"><nlm:aff id="A32">Department of Haematology and Oncologic Science, University Hospital Bologna, 40138 Bologna, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Haematology and Oncologic Science, University Hospital Bologna, 40138 Bologna</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Field, John" sort="Field, John" uniqKey="Field J" first="John" last="Field">John Field</name>
<affiliation wicri:level="1"><nlm:aff id="A33">Roy Castle Lung Cancer Research Programme, The University of Liverpool Cancer Research Centre, School of Cancer Studies, University of Liverpool Cancer Research Centre, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, The University of Liverpool. 200 London Road, Liverpool, L3 9TA, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Roy Castle Lung Cancer Research Programme, The University of Liverpool Cancer Research Centre, School of Cancer Studies, University of Liverpool Cancer Research Centre, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, The University of Liverpool. 200 London Road, Liverpool, L3 9TA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Solberg, Steinar" sort="Solberg, Steinar" uniqKey="Solberg S" first="Steinar" last="Solberg">Steinar Solberg</name>
<affiliation wicri:level="1"><nlm:aff id="A34">Department of Thoracic Surgery, Rikshospitalet, Oslo University Hospital, 0027 Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Thoracic Surgery, Rikshospitalet, Oslo University Hospital, 0027 Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brustugun, Odd Terje" sort="Brustugun, Odd Terje" uniqKey="Brustugun O" first="Odd Terje" last="Brustugun">Odd Terje Brustugun</name>
<affiliation wicri:level="1"><nlm:aff id="A35">Inst of clinical medicine, Faculty of medicine, University of Oslo, N-0424 Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Inst of clinical medicine, Faculty of medicine, University of Oslo, N-0424 Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A36">Dept of oncology, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Dept of oncology, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lund Iversen, Marius" sort="Lund Iversen, Marius" uniqKey="Lund Iversen M" first="Marius" last="Lund-Iversen">Marius Lund-Iversen</name>
<affiliation wicri:level="1"><nlm:aff id="A37">Dept of pathology, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Dept of pathology, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="S Nger, Jorg" sort="S Nger, Jorg" uniqKey="S Nger J" first="Jörg" last="S Nger">Jörg S Nger</name>
<affiliation wicri:level="1"><nlm:aff id="A38">Institute for Pathology Bad Berka, 99438 Bad Berka, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Pathology Bad Berka, 99438 Bad Berka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Clement, Joachim H" sort="Clement, Joachim H" uniqKey="Clement J" first="Joachim H" last="Clement">Joachim H. Clement</name>
<affiliation wicri:level="1"><nlm:aff id="A39">Department for Internal Medicine II, Jena University Hospital, Friedrich-Schiller University, 07740 Jena, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department for Internal Medicine II, Jena University Hospital, Friedrich-Schiller University, 07740 Jena</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Soltermann, Alex" sort="Soltermann, Alex" uniqKey="Soltermann A" first="Alex" last="Soltermann">Alex Soltermann</name>
<affiliation wicri:level="1"><nlm:aff id="A40">Institute for Surgical Pathology, University Hospital Zurich, 8091 Zurich, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Institute for Surgical Pathology, University Hospital Zurich, 8091 Zurich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Moch, Holger" sort="Moch, Holger" uniqKey="Moch H" first="Holger" last="Moch">Holger Moch</name>
<affiliation wicri:level="1"><nlm:aff id="A40">Institute for Surgical Pathology, University Hospital Zurich, 8091 Zurich, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Institute for Surgical Pathology, University Hospital Zurich, 8091 Zurich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Weder, Walter" sort="Weder, Walter" uniqKey="Weder W" first="Walter" last="Weder">Walter Weder</name>
<affiliation wicri:level="1"><nlm:aff id="A41">Division of Thoracic Surgery, University Hospital Zurich, 8091 Zurich, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Division of Thoracic Surgery, University Hospital Zurich, 8091 Zurich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Solomon, Benjamin" sort="Solomon, Benjamin" uniqKey="Solomon B" first="Benjamin" last="Solomon">Benjamin Solomon</name>
<affiliation wicri:level="1"><nlm:aff id="A42">Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, 3002 Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, 3002 Victoria</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Soria, Jean Charles" sort="Soria, Jean Charles" uniqKey="Soria J" first="Jean-Charles" last="Soria">Jean-Charles Soria</name>
<affiliation wicri:level="1"><nlm:aff id="A43">Phase I Unit–Department of Medicine, Institute Gustave Roussy, 39 Rue Camille Desmoulins, 94800 Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Phase I Unit–Department of Medicine, Institute Gustave Roussy, 39 Rue Camille Desmoulins, 94800 Villejuif</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Validire, Pierre" sort="Validire, Pierre" uniqKey="Validire P" first="Pierre" last="Validire">Pierre Validire</name>
<affiliation wicri:level="1"><nlm:aff id="A44">France Service d’Anatomie-Pathologie, Institut Mutualiste Montsouris, 75014 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>France Service d’Anatomie-Pathologie, Institut Mutualiste Montsouris, 75014 Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Besse, Benjamin" sort="Besse, Benjamin" uniqKey="Besse B" first="Benjamin" last="Besse">Benjamin Besse</name>
<affiliation wicri:level="1"><nlm:aff id="A43">Phase I Unit–Department of Medicine, Institute Gustave Roussy, 39 Rue Camille Desmoulins, 94800 Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Phase I Unit–Department of Medicine, Institute Gustave Roussy, 39 Rue Camille Desmoulins, 94800 Villejuif</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brambilla, Elisabeth" sort="Brambilla, Elisabeth" uniqKey="Brambilla E" first="Elisabeth" last="Brambilla">Elisabeth Brambilla</name>
<affiliation wicri:level="1"><nlm:aff id="A45">Department of Pathology, Université Joseph Fourier, 38041 Grenoble, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Pathology, Université Joseph Fourier, 38041 Grenoble</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A46">Institut Albert Bonniot INSERM U823, Université Joseph Fourier, 38042 Grenoble, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Albert Bonniot INSERM U823, Université Joseph Fourier, 38042 Grenoble</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brambilla, Christian" sort="Brambilla, Christian" uniqKey="Brambilla C" first="Christian" last="Brambilla">Christian Brambilla</name>
<affiliation wicri:level="1"><nlm:aff id="A45">Department of Pathology, Université Joseph Fourier, 38041 Grenoble, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Pathology, Université Joseph Fourier, 38041 Grenoble</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A46">Institut Albert Bonniot INSERM U823, Université Joseph Fourier, 38042 Grenoble, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Albert Bonniot INSERM U823, Université Joseph Fourier, 38042 Grenoble</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lantuejoul, Sylvie" sort="Lantuejoul, Sylvie" uniqKey="Lantuejoul S" first="Sylvie" last="Lantuejoul">Sylvie Lantuejoul</name>
<affiliation wicri:level="1"><nlm:aff id="A45">Department of Pathology, Université Joseph Fourier, 38041 Grenoble, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Pathology, Université Joseph Fourier, 38041 Grenoble</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A46">Institut Albert Bonniot INSERM U823, Université Joseph Fourier, 38042 Grenoble, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Albert Bonniot INSERM U823, Université Joseph Fourier, 38042 Grenoble</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lorimier, Philippe" sort="Lorimier, Philippe" uniqKey="Lorimier P" first="Philippe" last="Lorimier">Philippe Lorimier</name>
<affiliation wicri:level="1"><nlm:aff id="A45">Department of Pathology, Université Joseph Fourier, 38041 Grenoble, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Pathology, Université Joseph Fourier, 38041 Grenoble</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schneider, Peter M" sort="Schneider, Peter M" uniqKey="Schneider P" first="Peter M" last="Schneider">Peter M. Schneider</name>
<affiliation wicri:level="1"><nlm:aff id="A47">Institute of Legal Medicine, University of Cologne, Melatengürtel 60/62, 50823 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Legal Medicine, University of Cologne, Melatengürtel 60/62, 50823 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hallek, Michael" sort="Hallek, Michael" uniqKey="Hallek M" first="Michael" last="Hallek">Michael Hallek</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Department I of Internal Medicine and Center of Integrated Oncology Köln-Bonn, University of Cologne, 50924 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department I of Internal Medicine and Center of Integrated Oncology Köln-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A4">Laboratory of Translational Cancer Genomics, Center of Integrated Oncology Köln – Bonn, University of Cologne, 50924 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Laboratory of Translational Cancer Genomics, Center of Integrated Oncology Köln – Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pao, William" sort="Pao, William" uniqKey="Pao W" first="William" last="Pao">William Pao</name>
<affiliation wicri:level="1"><nlm:aff id="A48">Vanderbilt-Ingram Cancer Center, Nashville, TN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Vanderbilt-Ingram Cancer Center, Nashville, TN</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Meyerson, Matthew" sort="Meyerson, Matthew" uniqKey="Meyerson M" first="Matthew" last="Meyerson">Matthew Meyerson</name>
<affiliation wicri:level="1"><nlm:aff id="A12">The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A49">Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Harvard Medical School, Boston, Massachusetts 02115</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A50">Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A51">Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts 02115</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sage, Julien" sort="Sage, Julien" uniqKey="Sage J" first="Julien" last="Sage">Julien Sage</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Department of Pediatrics, Stanford University, Stanford, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, Stanford University, Stanford, California</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A14">Department of Genetics, Stanford University, Stanford, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, Stanford University, Stanford, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Shendure, Jay" sort="Shendure, Jay" uniqKey="Shendure J" first="Jay" last="Shendure">Jay Shendure</name>
<affiliation wicri:level="1"><nlm:aff id="A52">University of Washington, Department of Genome Sciences, Foege Building S- 250, Box 355065, 3720 15th Ave NE, Seattle, WA 98195-5065, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Washington, Department of Genome Sciences, Foege Building S- 250, Box 355065, 3720 15th Ave NE, Seattle, WA 98195-5065</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schneider, Robert" sort="Schneider, Robert" uniqKey="Schneider R" first="Robert" last="Schneider">Robert Schneider</name>
<affiliation wicri:level="1"><nlm:aff id="A8">Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A53">Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR 7104, INSERM U 964, Université de Strasbourg, 67404 Illkirch, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR 7104, INSERM U 964, Université de Strasbourg, 67404 Illkirch</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Buttner, Reinhard" sort="Buttner, Reinhard" uniqKey="Buttner R" first="Reinhard" last="Büttner">Reinhard Büttner</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Laboratory of Translational Cancer Genomics, Center of Integrated Oncology Köln – Bonn, University of Cologne, 50924 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Laboratory of Translational Cancer Genomics, Center of Integrated Oncology Köln – Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A9">Department of Pathology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Pathology, University of Cologne, Kerpener Str. 62, 50937 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wolf, Jurgen" sort="Wolf, Jurgen" uniqKey="Wolf J" first="Jürgen" last="Wolf">Jürgen Wolf</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Department I of Internal Medicine and Center of Integrated Oncology Köln-Bonn, University of Cologne, 50924 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department I of Internal Medicine and Center of Integrated Oncology Köln-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A4">Laboratory of Translational Cancer Genomics, Center of Integrated Oncology Köln – Bonn, University of Cologne, 50924 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Laboratory of Translational Cancer Genomics, Center of Integrated Oncology Köln – Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nurnberg, Peter" sort="Nurnberg, Peter" uniqKey="Nurnberg P" first="Peter" last="Nürnberg">Peter Nürnberg</name>
<affiliation wicri:level="1"><nlm:aff id="A10">Cologne Center for Genomics, University of Cologne, Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Cologne Center for Genomics, University of Cologne, Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A17">Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A54">Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Perner, Sven" sort="Perner, Sven" uniqKey="Perner S" first="Sven" last="Perner">Sven Perner</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Institute of Prostate Cancer Research at the Institute of Pathology, University Hospital of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Prostate Cancer Research at the Institute of Pathology, University Hospital of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Heukamp, Lukas C" sort="Heukamp, Lukas C" uniqKey="Heukamp L" first="Lukas C" last="Heukamp">Lukas C. Heukamp</name>
<affiliation wicri:level="1"><nlm:aff id="A9">Department of Pathology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Pathology, University of Cologne, Kerpener Str. 62, 50937 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brindle, Paul K" sort="Brindle, Paul K" uniqKey="Brindle P" first="Paul K" last="Brindle">Paul K. Brindle</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Department of Biochemistry, St Jude Children’s Research Hospital, Memphis, Tennessee 38105, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry, St Jude Children’s Research Hospital, Memphis, Tennessee 38105</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Haas, Stefan" sort="Haas, Stefan" uniqKey="Haas S" first="Stefan" last="Haas">Stefan Haas</name>
<affiliation wicri:level="1"><nlm:aff id="A6">Max Planck Institute for Molecular Genetics, Ihnestr. 73, 14194 Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max Planck Institute for Molecular Genetics, Ihnestr. 73, 14194 Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Thomas, Roman K" sort="Thomas, Roman K" uniqKey="Thomas R" first="Roman K" last="Thomas">Roman K. Thomas</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A3">Department I of Internal Medicine and Center of Integrated Oncology Köln-Bonn, University of Cologne, 50924 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department I of Internal Medicine and Center of Integrated Oncology Köln-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A4">Laboratory of Translational Cancer Genomics, Center of Integrated Oncology Köln – Bonn, University of Cologne, 50924 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Laboratory of Translational Cancer Genomics, Center of Integrated Oncology Köln – Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A9">Department of Pathology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Pathology, University of Cologne, Kerpener Str. 62, 50937 Cologne</wicri:regionArea>
</affiliation>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Integrative genome analyses identify key somatic driver mutations of small cell lung cancer</title>
<author><name sortKey="Peifer, Martin" sort="Peifer, Martin" uniqKey="Peifer M" first="Martin" last="Peifer">Martin Peifer</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fernandez Cuesta, Lynnette" sort="Fernandez Cuesta, Lynnette" uniqKey="Fernandez Cuesta L" first="Lynnette" last="Fernández-Cuesta">Lynnette Fernández-Cuesta</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sos, Martin L" sort="Sos, Martin L" uniqKey="Sos M" first="Martin L" last="Sos">Martin L. Sos</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A3">Department I of Internal Medicine and Center of Integrated Oncology Köln-Bonn, University of Cologne, 50924 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department I of Internal Medicine and Center of Integrated Oncology Köln-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="George, Julie" sort="George, Julie" uniqKey="George J" first="Julie" last="George">Julie George</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Seidel, Danila" sort="Seidel, Danila" uniqKey="Seidel D" first="Danila" last="Seidel">Danila Seidel</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A4">Laboratory of Translational Cancer Genomics, Center of Integrated Oncology Köln – Bonn, University of Cologne, 50924 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Laboratory of Translational Cancer Genomics, Center of Integrated Oncology Köln – Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kasper, Lawryn H" sort="Kasper, Lawryn H" uniqKey="Kasper L" first="Lawryn H" last="Kasper">Lawryn H. Kasper</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Department of Biochemistry, St Jude Children’s Research Hospital, Memphis, Tennessee 38105, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry, St Jude Children’s Research Hospital, Memphis, Tennessee 38105</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Plenker, Dennis" sort="Plenker, Dennis" uniqKey="Plenker D" first="Dennis" last="Plenker">Dennis Plenker</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Leenders, Frauke" sort="Leenders, Frauke" uniqKey="Leenders F" first="Frauke" last="Leenders">Frauke Leenders</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A4">Laboratory of Translational Cancer Genomics, Center of Integrated Oncology Köln – Bonn, University of Cologne, 50924 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Laboratory of Translational Cancer Genomics, Center of Integrated Oncology Köln – Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sun, Ruping" sort="Sun, Ruping" uniqKey="Sun R" first="Ruping" last="Sun">Ruping Sun</name>
<affiliation wicri:level="1"><nlm:aff id="A6">Max Planck Institute for Molecular Genetics, Ihnestr. 73, 14194 Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max Planck Institute for Molecular Genetics, Ihnestr. 73, 14194 Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zander, Thomas" sort="Zander, Thomas" uniqKey="Zander T" first="Thomas" last="Zander">Thomas Zander</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A3">Department I of Internal Medicine and Center of Integrated Oncology Köln-Bonn, University of Cologne, 50924 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department I of Internal Medicine and Center of Integrated Oncology Köln-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Menon, Roopika" sort="Menon, Roopika" uniqKey="Menon R" first="Roopika" last="Menon">Roopika Menon</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Institute of Prostate Cancer Research at the Institute of Pathology, University Hospital of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Prostate Cancer Research at the Institute of Pathology, University Hospital of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Koker, Mirjam" sort="Koker, Mirjam" uniqKey="Koker M" first="Mirjam" last="Koker">Mirjam Koker</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dahmen, Ilona" sort="Dahmen, Ilona" uniqKey="Dahmen I" first="Ilona" last="Dahmen">Ilona Dahmen</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Muller, Christian" sort="Muller, Christian" uniqKey="Muller C" first="Christian" last="Müller">Christian Müller</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Di Cerbo, Vincenzo" sort="Di Cerbo, Vincenzo" uniqKey="Di Cerbo V" first="Vincenzo" last="Di Cerbo">Vincenzo Di Cerbo</name>
<affiliation wicri:level="1"><nlm:aff id="A8">Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schildhaus, Hans Ulrich" sort="Schildhaus, Hans Ulrich" uniqKey="Schildhaus H" first="Hans-Ulrich" last="Schildhaus">Hans-Ulrich Schildhaus</name>
<affiliation wicri:level="1"><nlm:aff id="A9">Department of Pathology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Pathology, University of Cologne, Kerpener Str. 62, 50937 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Altmuller, Janine" sort="Altmuller, Janine" uniqKey="Altmuller J" first="Janine" last="Altmüller">Janine Altmüller</name>
<affiliation wicri:level="1"><nlm:aff id="A10">Cologne Center for Genomics, University of Cologne, Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Cologne Center for Genomics, University of Cologne, Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Baessmann, Ingelore" sort="Baessmann, Ingelore" uniqKey="Baessmann I" first="Ingelore" last="Baessmann">Ingelore Baessmann</name>
<affiliation wicri:level="1"><nlm:aff id="A10">Cologne Center for Genomics, University of Cologne, Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Cologne Center for Genomics, University of Cologne, Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Becker, Christian" sort="Becker, Christian" uniqKey="Becker C" first="Christian" last="Becker">Christian Becker</name>
<affiliation wicri:level="1"><nlm:aff id="A10">Cologne Center for Genomics, University of Cologne, Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Cologne Center for Genomics, University of Cologne, Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="De Wilde, Bram" sort="De Wilde, Bram" uniqKey="De Wilde B" first="Bram" last="De Wilde">Bram De Wilde</name>
<affiliation wicri:level="1"><nlm:aff id="A11">Center for Medical Genetics, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Center for Medical Genetics, Ghent University, De Pintelaan 185, 9000 Ghent</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vandesompele, Jo" sort="Vandesompele, Jo" uniqKey="Vandesompele J" first="Jo" last="Vandesompele">Jo Vandesompele</name>
<affiliation wicri:level="1"><nlm:aff id="A11">Center for Medical Genetics, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Center for Medical Genetics, Ghent University, De Pintelaan 185, 9000 Ghent</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bohm, Diana" sort="Bohm, Diana" uniqKey="Bohm D" first="Diana" last="Böhm">Diana Böhm</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Institute of Prostate Cancer Research at the Institute of Pathology, University Hospital of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Prostate Cancer Research at the Institute of Pathology, University Hospital of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ansen, Sascha" sort="Ansen, Sascha" uniqKey="Ansen S" first="Sascha" last="Ansén">Sascha Ansén</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Department I of Internal Medicine and Center of Integrated Oncology Köln-Bonn, University of Cologne, 50924 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department I of Internal Medicine and Center of Integrated Oncology Köln-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gabler, Franziska" sort="Gabler, Franziska" uniqKey="Gabler F" first="Franziska" last="Gabler">Franziska Gabler</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wilkening, Ines" sort="Wilkening, Ines" uniqKey="Wilkening I" first="Ines" last="Wilkening">Ines Wilkening</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Heynck, Stefanie" sort="Heynck, Stefanie" uniqKey="Heynck S" first="Stefanie" last="Heynck">Stefanie Heynck</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Heuckmann, Johannes M" sort="Heuckmann, Johannes M" uniqKey="Heuckmann J" first="Johannes M" last="Heuckmann">Johannes M. Heuckmann</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lu, Xin" sort="Lu, Xin" uniqKey="Lu X" first="Xin" last="Lu">Xin Lu</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Carter, Scott L" sort="Carter, Scott L" uniqKey="Carter S" first="Scott L" last="Carter">Scott L. Carter</name>
<affiliation wicri:level="1"><nlm:aff id="A12">The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cibulskis, Kristian" sort="Cibulskis, Kristian" uniqKey="Cibulskis K" first="Kristian" last="Cibulskis">Kristian Cibulskis</name>
<affiliation wicri:level="1"><nlm:aff id="A12">The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Banerji, Shantanu" sort="Banerji, Shantanu" uniqKey="Banerji S" first="Shantanu" last="Banerji">Shantanu Banerji</name>
<affiliation wicri:level="1"><nlm:aff id="A12">The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Getz, Gad" sort="Getz, Gad" uniqKey="Getz G" first="Gad" last="Getz">Gad Getz</name>
<affiliation wicri:level="1"><nlm:aff id="A12">The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Park, Kwon Sik" sort="Park, Kwon Sik" uniqKey="Park K" first="Kwon-Sik" last="Park">Kwon-Sik Park</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Department of Pediatrics, Stanford University, Stanford, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, Stanford University, Stanford, California</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A14">Department of Genetics, Stanford University, Stanford, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, Stanford University, Stanford, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rauh, Daniel" sort="Rauh, Daniel" uniqKey="Rauh D" first="Daniel" last="Rauh">Daniel Rauh</name>
<affiliation wicri:level="1"><nlm:aff id="A15">Technical University Dortmund, Department of Chemical Biology, Otto-Hahn-Str. 6, 44227 Dortmund, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Technical University Dortmund, Department of Chemical Biology, Otto-Hahn-Str. 6, 44227 Dortmund</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Grutter, Christian" sort="Grutter, Christian" uniqKey="Grutter C" first="Christian" last="Grütter">Christian Grütter</name>
<affiliation wicri:level="1"><nlm:aff id="A15">Technical University Dortmund, Department of Chemical Biology, Otto-Hahn-Str. 6, 44227 Dortmund, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Technical University Dortmund, Department of Chemical Biology, Otto-Hahn-Str. 6, 44227 Dortmund</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fischer, Matthias" sort="Fischer, Matthias" uniqKey="Fischer M" first="Matthias" last="Fischer">Matthias Fischer</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Department of Pediatric Oncology and Hematology, University Children’s Hospital of Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Pediatric Oncology and Hematology, University Children’s Hospital of Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A17">Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pasqualucci, Laura" sort="Pasqualucci, Laura" uniqKey="Pasqualucci L" first="Laura" last="Pasqualucci">Laura Pasqualucci</name>
<affiliation wicri:level="1"><nlm:aff id="A18">Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wright, Gavin" sort="Wright, Gavin" uniqKey="Wright G" first="Gavin" last="Wright">Gavin Wright</name>
<affiliation wicri:level="1"><nlm:aff id="A19">The University of Melbourne Department of Surgery, St Vincent’s Hospital, Level 2, Clinical Sciences Building 29 Regent Street, Melbourne, 3065 Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The University of Melbourne Department of Surgery, St Vincent’s Hospital, Level 2, Clinical Sciences Building 29 Regent Street, Melbourne, 3065 Victoria</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wainer, Zoe" sort="Wainer, Zoe" uniqKey="Wainer Z" first="Zoe" last="Wainer">Zoe Wainer</name>
<affiliation wicri:level="1"><nlm:aff id="A19">The University of Melbourne Department of Surgery, St Vincent’s Hospital, Level 2, Clinical Sciences Building 29 Regent Street, Melbourne, 3065 Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The University of Melbourne Department of Surgery, St Vincent’s Hospital, Level 2, Clinical Sciences Building 29 Regent Street, Melbourne, 3065 Victoria</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Russell, Prudence" sort="Russell, Prudence" uniqKey="Russell P" first="Prudence" last="Russell">Prudence Russell</name>
<affiliation wicri:level="1"><nlm:aff id="A20">Department of Pathology, St. Vincent’s Hospital, Melbourne, 3065 Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Pathology, St. Vincent’s Hospital, Melbourne, 3065 Victoria</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Petersen, Iver" sort="Petersen, Iver" uniqKey="Petersen I" first="Iver" last="Petersen">Iver Petersen</name>
<affiliation wicri:level="1"><nlm:aff id="A21">Institute of Pathology, Jena University Hospital, Friedrich-Schiller-University, 07743 Jena, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Pathology, Jena University Hospital, Friedrich-Schiller-University, 07743 Jena</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chen, Yuan" sort="Chen, Yuan" uniqKey="Chen Y" first="Yuan" last="Chen">Yuan Chen</name>
<affiliation wicri:level="1"><nlm:aff id="A21">Institute of Pathology, Jena University Hospital, Friedrich-Schiller-University, 07743 Jena, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Pathology, Jena University Hospital, Friedrich-Schiller-University, 07743 Jena</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stoelben, Erich" sort="Stoelben, Erich" uniqKey="Stoelben E" first="Erich" last="Stoelben">Erich Stoelben</name>
<affiliation wicri:level="1"><nlm:aff id="A22">Thoracic Surgery, Lungenklinik Merheim, Kliniken der Stadt Köln gGmbH, 51109 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Thoracic Surgery, Lungenklinik Merheim, Kliniken der Stadt Köln gGmbH, 51109 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ludwig, Corinna" sort="Ludwig, Corinna" uniqKey="Ludwig C" first="Corinna" last="Ludwig">Corinna Ludwig</name>
<affiliation wicri:level="1"><nlm:aff id="A22">Thoracic Surgery, Lungenklinik Merheim, Kliniken der Stadt Köln gGmbH, 51109 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Thoracic Surgery, Lungenklinik Merheim, Kliniken der Stadt Köln gGmbH, 51109 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schnabel, Philipp" sort="Schnabel, Philipp" uniqKey="Schnabel P" first="Philipp" last="Schnabel">Philipp Schnabel</name>
<affiliation wicri:level="1"><nlm:aff id="A23">Institute of Pathology, Im Neuenheimer Feld 220, 69120 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Pathology, Im Neuenheimer Feld 220, 69120 Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hoffmann, Hans" sort="Hoffmann, Hans" uniqKey="Hoffmann H" first="Hans" last="Hoffmann">Hans Hoffmann</name>
<affiliation wicri:level="1"><nlm:aff id="A24">Thoraxklinik-Heidelberg gGmbH, Amalienstr. 5, 69126 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Thoraxklinik-Heidelberg gGmbH, Amalienstr. 5, 69126 Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Muley, Thomas" sort="Muley, Thomas" uniqKey="Muley T" first="Thomas" last="Muley">Thomas Muley</name>
<affiliation wicri:level="1"><nlm:aff id="A24">Thoraxklinik-Heidelberg gGmbH, Amalienstr. 5, 69126 Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Thoraxklinik-Heidelberg gGmbH, Amalienstr. 5, 69126 Heidelberg</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brockmann, Michael" sort="Brockmann, Michael" uniqKey="Brockmann M" first="Michael" last="Brockmann">Michael Brockmann</name>
<affiliation wicri:level="1"><nlm:aff id="A25">Department of Pathology, Hospital Merheim, Kliniken der Stadt Köln gGmbH, 51109 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Pathology, Hospital Merheim, Kliniken der Stadt Köln gGmbH, 51109 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Engel Riedel, Walburga" sort="Engel Riedel, Walburga" uniqKey="Engel Riedel W" first="Walburga" last="Engel-Riedel">Walburga Engel-Riedel</name>
<affiliation wicri:level="1"><nlm:aff id="A22">Thoracic Surgery, Lungenklinik Merheim, Kliniken der Stadt Köln gGmbH, 51109 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Thoracic Surgery, Lungenklinik Merheim, Kliniken der Stadt Köln gGmbH, 51109 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Muscarella, Lucia A" sort="Muscarella, Lucia A" uniqKey="Muscarella L" first="Lucia A" last="Muscarella">Lucia A. Muscarella</name>
<affiliation wicri:level="1"><nlm:aff id="A26">Laboratory of Oncology, IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini, 71013 San Giovanni Rotondo, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Laboratory of Oncology, IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini, 71013 San Giovanni Rotondo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fazio, Vito M" sort="Fazio, Vito M" uniqKey="Fazio V" first="Vito M" last="Fazio">Vito M. Fazio</name>
<affiliation wicri:level="1"><nlm:aff id="A26">Laboratory of Oncology, IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini, 71013 San Giovanni Rotondo, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Laboratory of Oncology, IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini, 71013 San Giovanni Rotondo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Groen, Harry" sort="Groen, Harry" uniqKey="Groen H" first="Harry" last="Groen">Harry Groen</name>
<affiliation wicri:level="1"><nlm:aff id="A27">Department of Pulmonary Diseases, University Medical Centre Groningen, 9713 GZ Groningen, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Pulmonary Diseases, University Medical Centre Groningen, 9713 GZ Groningen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Timens, Wim" sort="Timens, Wim" uniqKey="Timens W" first="Wim" last="Timens">Wim Timens</name>
<affiliation wicri:level="1"><nlm:aff id="A28">Department of Pathology, University Medical Centre Groningen, 9713 GZ Groningen, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Pathology, University Medical Centre Groningen, 9713 GZ Groningen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sietsma, Hannie" sort="Sietsma, Hannie" uniqKey="Sietsma H" first="Hannie" last="Sietsma">Hannie Sietsma</name>
<affiliation wicri:level="1"><nlm:aff id="A28">Department of Pathology, University Medical Centre Groningen, 9713 GZ Groningen, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Pathology, University Medical Centre Groningen, 9713 GZ Groningen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Thunnissen, Erik" sort="Thunnissen, Erik" uniqKey="Thunnissen E" first="Erik" last="Thunnissen">Erik Thunnissen</name>
<affiliation wicri:level="1"><nlm:aff id="A29">Department of Pathology, VU University Medical Center Amsterdam, 1007 MB Amsterdam, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Pathology, VU University Medical Center Amsterdam, 1007 MB Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Smit, Egbert" sort="Smit, Egbert" uniqKey="Smit E" first="Egbert" last="Smit">Egbert Smit</name>
<affiliation wicri:level="1"><nlm:aff id="A30">Department of Pulmonary Diseases, VU University Medical Center Amsterdam, 1007 MB Amsterdam, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Pulmonary Diseases, VU University Medical Center Amsterdam, 1007 MB Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Heideman, Danielle Am" sort="Heideman, Danielle Am" uniqKey="Heideman D" first="Daniëlle Am" last="Heideman">Daniëlle Am Heideman</name>
<affiliation wicri:level="1"><nlm:aff id="A29">Department of Pathology, VU University Medical Center Amsterdam, 1007 MB Amsterdam, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Pathology, VU University Medical Center Amsterdam, 1007 MB Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Snijders, Peter Jf" sort="Snijders, Peter Jf" uniqKey="Snijders P" first="Peter Jf" last="Snijders">Peter Jf Snijders</name>
<affiliation wicri:level="1"><nlm:aff id="A29">Department of Pathology, VU University Medical Center Amsterdam, 1007 MB Amsterdam, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Pathology, VU University Medical Center Amsterdam, 1007 MB Amsterdam</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cappuzzo, Federico" sort="Cappuzzo, Federico" uniqKey="Cappuzzo F" first="Federico" last="Cappuzzo">Federico Cappuzzo</name>
<affiliation wicri:level="1"><nlm:aff id="A31">Department of Medical Oncology, Ospedale Civile, 57100 Livorno, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medical Oncology, Ospedale Civile, 57100 Livorno</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ligorio, Claudia" sort="Ligorio, Claudia" uniqKey="Ligorio C" first="Claudia" last="Ligorio">Claudia Ligorio</name>
<affiliation wicri:level="1"><nlm:aff id="A32">Department of Haematology and Oncologic Science, University Hospital Bologna, 40138 Bologna, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Haematology and Oncologic Science, University Hospital Bologna, 40138 Bologna</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Damiani, Stefania" sort="Damiani, Stefania" uniqKey="Damiani S" first="Stefania" last="Damiani">Stefania Damiani</name>
<affiliation wicri:level="1"><nlm:aff id="A32">Department of Haematology and Oncologic Science, University Hospital Bologna, 40138 Bologna, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Haematology and Oncologic Science, University Hospital Bologna, 40138 Bologna</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Field, John" sort="Field, John" uniqKey="Field J" first="John" last="Field">John Field</name>
<affiliation wicri:level="1"><nlm:aff id="A33">Roy Castle Lung Cancer Research Programme, The University of Liverpool Cancer Research Centre, School of Cancer Studies, University of Liverpool Cancer Research Centre, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, The University of Liverpool. 200 London Road, Liverpool, L3 9TA, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Roy Castle Lung Cancer Research Programme, The University of Liverpool Cancer Research Centre, School of Cancer Studies, University of Liverpool Cancer Research Centre, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, The University of Liverpool. 200 London Road, Liverpool, L3 9TA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Solberg, Steinar" sort="Solberg, Steinar" uniqKey="Solberg S" first="Steinar" last="Solberg">Steinar Solberg</name>
<affiliation wicri:level="1"><nlm:aff id="A34">Department of Thoracic Surgery, Rikshospitalet, Oslo University Hospital, 0027 Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Thoracic Surgery, Rikshospitalet, Oslo University Hospital, 0027 Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brustugun, Odd Terje" sort="Brustugun, Odd Terje" uniqKey="Brustugun O" first="Odd Terje" last="Brustugun">Odd Terje Brustugun</name>
<affiliation wicri:level="1"><nlm:aff id="A35">Inst of clinical medicine, Faculty of medicine, University of Oslo, N-0424 Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Inst of clinical medicine, Faculty of medicine, University of Oslo, N-0424 Oslo</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A36">Dept of oncology, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Dept of oncology, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lund Iversen, Marius" sort="Lund Iversen, Marius" uniqKey="Lund Iversen M" first="Marius" last="Lund-Iversen">Marius Lund-Iversen</name>
<affiliation wicri:level="1"><nlm:aff id="A37">Dept of pathology, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Dept of pathology, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="S Nger, Jorg" sort="S Nger, Jorg" uniqKey="S Nger J" first="Jörg" last="S Nger">Jörg S Nger</name>
<affiliation wicri:level="1"><nlm:aff id="A38">Institute for Pathology Bad Berka, 99438 Bad Berka, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Pathology Bad Berka, 99438 Bad Berka</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Clement, Joachim H" sort="Clement, Joachim H" uniqKey="Clement J" first="Joachim H" last="Clement">Joachim H. Clement</name>
<affiliation wicri:level="1"><nlm:aff id="A39">Department for Internal Medicine II, Jena University Hospital, Friedrich-Schiller University, 07740 Jena, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department for Internal Medicine II, Jena University Hospital, Friedrich-Schiller University, 07740 Jena</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Soltermann, Alex" sort="Soltermann, Alex" uniqKey="Soltermann A" first="Alex" last="Soltermann">Alex Soltermann</name>
<affiliation wicri:level="1"><nlm:aff id="A40">Institute for Surgical Pathology, University Hospital Zurich, 8091 Zurich, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Institute for Surgical Pathology, University Hospital Zurich, 8091 Zurich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Moch, Holger" sort="Moch, Holger" uniqKey="Moch H" first="Holger" last="Moch">Holger Moch</name>
<affiliation wicri:level="1"><nlm:aff id="A40">Institute for Surgical Pathology, University Hospital Zurich, 8091 Zurich, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Institute for Surgical Pathology, University Hospital Zurich, 8091 Zurich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Weder, Walter" sort="Weder, Walter" uniqKey="Weder W" first="Walter" last="Weder">Walter Weder</name>
<affiliation wicri:level="1"><nlm:aff id="A41">Division of Thoracic Surgery, University Hospital Zurich, 8091 Zurich, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Division of Thoracic Surgery, University Hospital Zurich, 8091 Zurich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Solomon, Benjamin" sort="Solomon, Benjamin" uniqKey="Solomon B" first="Benjamin" last="Solomon">Benjamin Solomon</name>
<affiliation wicri:level="1"><nlm:aff id="A42">Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, 3002 Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, 3002 Victoria</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Soria, Jean Charles" sort="Soria, Jean Charles" uniqKey="Soria J" first="Jean-Charles" last="Soria">Jean-Charles Soria</name>
<affiliation wicri:level="1"><nlm:aff id="A43">Phase I Unit–Department of Medicine, Institute Gustave Roussy, 39 Rue Camille Desmoulins, 94800 Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Phase I Unit–Department of Medicine, Institute Gustave Roussy, 39 Rue Camille Desmoulins, 94800 Villejuif</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Validire, Pierre" sort="Validire, Pierre" uniqKey="Validire P" first="Pierre" last="Validire">Pierre Validire</name>
<affiliation wicri:level="1"><nlm:aff id="A44">France Service d’Anatomie-Pathologie, Institut Mutualiste Montsouris, 75014 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>France Service d’Anatomie-Pathologie, Institut Mutualiste Montsouris, 75014 Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Besse, Benjamin" sort="Besse, Benjamin" uniqKey="Besse B" first="Benjamin" last="Besse">Benjamin Besse</name>
<affiliation wicri:level="1"><nlm:aff id="A43">Phase I Unit–Department of Medicine, Institute Gustave Roussy, 39 Rue Camille Desmoulins, 94800 Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Phase I Unit–Department of Medicine, Institute Gustave Roussy, 39 Rue Camille Desmoulins, 94800 Villejuif</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brambilla, Elisabeth" sort="Brambilla, Elisabeth" uniqKey="Brambilla E" first="Elisabeth" last="Brambilla">Elisabeth Brambilla</name>
<affiliation wicri:level="1"><nlm:aff id="A45">Department of Pathology, Université Joseph Fourier, 38041 Grenoble, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Pathology, Université Joseph Fourier, 38041 Grenoble</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A46">Institut Albert Bonniot INSERM U823, Université Joseph Fourier, 38042 Grenoble, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Albert Bonniot INSERM U823, Université Joseph Fourier, 38042 Grenoble</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brambilla, Christian" sort="Brambilla, Christian" uniqKey="Brambilla C" first="Christian" last="Brambilla">Christian Brambilla</name>
<affiliation wicri:level="1"><nlm:aff id="A45">Department of Pathology, Université Joseph Fourier, 38041 Grenoble, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Pathology, Université Joseph Fourier, 38041 Grenoble</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A46">Institut Albert Bonniot INSERM U823, Université Joseph Fourier, 38042 Grenoble, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Albert Bonniot INSERM U823, Université Joseph Fourier, 38042 Grenoble</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lantuejoul, Sylvie" sort="Lantuejoul, Sylvie" uniqKey="Lantuejoul S" first="Sylvie" last="Lantuejoul">Sylvie Lantuejoul</name>
<affiliation wicri:level="1"><nlm:aff id="A45">Department of Pathology, Université Joseph Fourier, 38041 Grenoble, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Pathology, Université Joseph Fourier, 38041 Grenoble</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A46">Institut Albert Bonniot INSERM U823, Université Joseph Fourier, 38042 Grenoble, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Albert Bonniot INSERM U823, Université Joseph Fourier, 38042 Grenoble</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lorimier, Philippe" sort="Lorimier, Philippe" uniqKey="Lorimier P" first="Philippe" last="Lorimier">Philippe Lorimier</name>
<affiliation wicri:level="1"><nlm:aff id="A45">Department of Pathology, Université Joseph Fourier, 38041 Grenoble, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Pathology, Université Joseph Fourier, 38041 Grenoble</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schneider, Peter M" sort="Schneider, Peter M" uniqKey="Schneider P" first="Peter M" last="Schneider">Peter M. Schneider</name>
<affiliation wicri:level="1"><nlm:aff id="A47">Institute of Legal Medicine, University of Cologne, Melatengürtel 60/62, 50823 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Legal Medicine, University of Cologne, Melatengürtel 60/62, 50823 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hallek, Michael" sort="Hallek, Michael" uniqKey="Hallek M" first="Michael" last="Hallek">Michael Hallek</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Department I of Internal Medicine and Center of Integrated Oncology Köln-Bonn, University of Cologne, 50924 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department I of Internal Medicine and Center of Integrated Oncology Köln-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A4">Laboratory of Translational Cancer Genomics, Center of Integrated Oncology Köln – Bonn, University of Cologne, 50924 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Laboratory of Translational Cancer Genomics, Center of Integrated Oncology Köln – Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pao, William" sort="Pao, William" uniqKey="Pao W" first="William" last="Pao">William Pao</name>
<affiliation wicri:level="1"><nlm:aff id="A48">Vanderbilt-Ingram Cancer Center, Nashville, TN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Vanderbilt-Ingram Cancer Center, Nashville, TN</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Meyerson, Matthew" sort="Meyerson, Matthew" uniqKey="Meyerson M" first="Matthew" last="Meyerson">Matthew Meyerson</name>
<affiliation wicri:level="1"><nlm:aff id="A12">The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A49">Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Harvard Medical School, Boston, Massachusetts 02115</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A50">Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A51">Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts 02115</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sage, Julien" sort="Sage, Julien" uniqKey="Sage J" first="Julien" last="Sage">Julien Sage</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Department of Pediatrics, Stanford University, Stanford, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, Stanford University, Stanford, California</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A14">Department of Genetics, Stanford University, Stanford, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, Stanford University, Stanford, California</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Shendure, Jay" sort="Shendure, Jay" uniqKey="Shendure J" first="Jay" last="Shendure">Jay Shendure</name>
<affiliation wicri:level="1"><nlm:aff id="A52">University of Washington, Department of Genome Sciences, Foege Building S- 250, Box 355065, 3720 15th Ave NE, Seattle, WA 98195-5065, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Washington, Department of Genome Sciences, Foege Building S- 250, Box 355065, 3720 15th Ave NE, Seattle, WA 98195-5065</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schneider, Robert" sort="Schneider, Robert" uniqKey="Schneider R" first="Robert" last="Schneider">Robert Schneider</name>
<affiliation wicri:level="1"><nlm:aff id="A8">Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A53">Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR 7104, INSERM U 964, Université de Strasbourg, 67404 Illkirch, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR 7104, INSERM U 964, Université de Strasbourg, 67404 Illkirch</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Buttner, Reinhard" sort="Buttner, Reinhard" uniqKey="Buttner R" first="Reinhard" last="Büttner">Reinhard Büttner</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Laboratory of Translational Cancer Genomics, Center of Integrated Oncology Köln – Bonn, University of Cologne, 50924 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Laboratory of Translational Cancer Genomics, Center of Integrated Oncology Köln – Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A9">Department of Pathology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Pathology, University of Cologne, Kerpener Str. 62, 50937 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wolf, Jurgen" sort="Wolf, Jurgen" uniqKey="Wolf J" first="Jürgen" last="Wolf">Jürgen Wolf</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Department I of Internal Medicine and Center of Integrated Oncology Köln-Bonn, University of Cologne, 50924 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department I of Internal Medicine and Center of Integrated Oncology Köln-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A4">Laboratory of Translational Cancer Genomics, Center of Integrated Oncology Köln – Bonn, University of Cologne, 50924 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Laboratory of Translational Cancer Genomics, Center of Integrated Oncology Köln – Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nurnberg, Peter" sort="Nurnberg, Peter" uniqKey="Nurnberg P" first="Peter" last="Nürnberg">Peter Nürnberg</name>
<affiliation wicri:level="1"><nlm:aff id="A10">Cologne Center for Genomics, University of Cologne, Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Cologne Center for Genomics, University of Cologne, Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A17">Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A54">Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Perner, Sven" sort="Perner, Sven" uniqKey="Perner S" first="Sven" last="Perner">Sven Perner</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Institute of Prostate Cancer Research at the Institute of Pathology, University Hospital of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Prostate Cancer Research at the Institute of Pathology, University Hospital of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Heukamp, Lukas C" sort="Heukamp, Lukas C" uniqKey="Heukamp L" first="Lukas C" last="Heukamp">Lukas C. Heukamp</name>
<affiliation wicri:level="1"><nlm:aff id="A9">Department of Pathology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Pathology, University of Cologne, Kerpener Str. 62, 50937 Cologne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brindle, Paul K" sort="Brindle, Paul K" uniqKey="Brindle P" first="Paul K" last="Brindle">Paul K. Brindle</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Department of Biochemistry, St Jude Children’s Research Hospital, Memphis, Tennessee 38105, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry, St Jude Children’s Research Hospital, Memphis, Tennessee 38105</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Haas, Stefan" sort="Haas, Stefan" uniqKey="Haas S" first="Stefan" last="Haas">Stefan Haas</name>
<affiliation wicri:level="1"><nlm:aff id="A6">Max Planck Institute for Molecular Genetics, Ihnestr. 73, 14194 Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max Planck Institute for Molecular Genetics, Ihnestr. 73, 14194 Berlin</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Thomas, Roman K" sort="Thomas, Roman K" uniqKey="Thomas R" first="Roman K" last="Thomas">Roman K. Thomas</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A3">Department I of Internal Medicine and Center of Integrated Oncology Köln-Bonn, University of Cologne, 50924 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department I of Internal Medicine and Center of Integrated Oncology Köln-Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A4">Laboratory of Translational Cancer Genomics, Center of Integrated Oncology Köln – Bonn, University of Cologne, 50924 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Laboratory of Translational Cancer Genomics, Center of Integrated Oncology Köln – Bonn, University of Cologne, 50924 Cologne</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A9">Department of Pathology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Pathology, University of Cologne, Kerpener Str. 62, 50937 Cologne</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Nature genetics</title>
<idno type="ISSN">1061-4036</idno>
<idno type="eISSN">1546-1718</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Small-cell lung cancer (SCLC) is an aggressive lung tumor subtype with poor survival<sup><xref rid="R1" ref-type="bibr">1</xref>
–<xref rid="R3" ref-type="bibr">3</xref>
</sup>
. We sequenced 29 SCLC exomes, two genomes and 15 transcriptomes and found an extremely high mutation rate of 7.4±1 protein-changing mutations per million basepairs. Therefore, we conducted integrated analyses of the various data sets to identify pathogenetically relevant mutated genes. In all cases we found evidence for inactivation of <italic>TP53</italic>
and <italic>RB1</italic>
and identified recurrent mutations in histone-modifying genes, <italic>CREBBP</italic>
, <italic>EP300</italic>
, and <italic>MLL</italic>
. Furthermore, we observed mutations in <italic>PTEN</italic>
, in <italic>SLIT2</italic>
, and <italic>EPHA7</italic>
, as well as focal amplifications of the <italic>FGFR1</italic>
tyrosine kinase gene. Finally, we detected many of the alterations found in humans in SCLC tumors from <italic>p53/Rb1</italic>
-deficient mice<sup><xref rid="R4" ref-type="bibr">4</xref>
</sup>
. Our study implicates histone modification as a major feature of SCLC, reveals potentially therapeutically tractable genome alterations, and provides a generalizable framework for identification of biologically relevant genes in the context of high mutational background.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9216904</journal-id>
<journal-id journal-id-type="pubmed-jr-id">2419</journal-id>
<journal-id journal-id-type="nlm-ta">Nat Genet</journal-id>
<journal-id journal-id-type="iso-abbrev">Nat. Genet.</journal-id>
<journal-title-group><journal-title>Nature genetics</journal-title>
</journal-title-group>
<issn pub-type="ppub">1061-4036</issn>
<issn pub-type="epub">1546-1718</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">22941188</article-id>
<article-id pub-id-type="pmc">4915822</article-id>
<article-id pub-id-type="doi">10.1038/ng.2396</article-id>
<article-id pub-id-type="manuscript">NIHMS793416</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Integrative genome analyses identify key somatic driver mutations of small cell lung cancer</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Peifer</surname>
<given-names>Martin</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref rid="FN2" ref-type="author-notes">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fernández-Cuesta</surname>
<given-names>Lynnette</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref rid="FN2" ref-type="author-notes">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sos</surname>
<given-names>Martin L</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>George</surname>
<given-names>Julie</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Seidel</surname>
<given-names>Danila</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kasper</surname>
<given-names>Lawryn H</given-names>
</name>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Plenker</surname>
<given-names>Dennis</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Leenders</surname>
<given-names>Frauke</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sun</surname>
<given-names>Ruping</given-names>
</name>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zander</surname>
<given-names>Thomas</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Menon</surname>
<given-names>Roopika</given-names>
</name>
<xref ref-type="aff" rid="A7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Koker</surname>
<given-names>Mirjam</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dahmen</surname>
<given-names>Ilona</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Müller</surname>
<given-names>Christian</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Di Cerbo</surname>
<given-names>Vincenzo</given-names>
</name>
<xref ref-type="aff" rid="A8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schildhaus</surname>
<given-names>Hans-Ulrich</given-names>
</name>
<xref ref-type="aff" rid="A9">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Altmüller</surname>
<given-names>Janine</given-names>
</name>
<xref ref-type="aff" rid="A10">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Baessmann</surname>
<given-names>Ingelore</given-names>
</name>
<xref ref-type="aff" rid="A10">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Becker</surname>
<given-names>Christian</given-names>
</name>
<xref ref-type="aff" rid="A10">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>de Wilde</surname>
<given-names>Bram</given-names>
</name>
<xref ref-type="aff" rid="A11">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vandesompele</surname>
<given-names>Jo</given-names>
</name>
<xref ref-type="aff" rid="A11">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Böhm</surname>
<given-names>Diana</given-names>
</name>
<xref ref-type="aff" rid="A7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ansén</surname>
<given-names>Sascha</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gabler</surname>
<given-names>Franziska</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wilkening</surname>
<given-names>Ines</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Heynck</surname>
<given-names>Stefanie</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Heuckmann</surname>
<given-names>Johannes M</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lu</surname>
<given-names>Xin</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Carter</surname>
<given-names>Scott L</given-names>
</name>
<xref ref-type="aff" rid="A12">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cibulskis</surname>
<given-names>Kristian</given-names>
</name>
<xref ref-type="aff" rid="A12">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Banerji</surname>
<given-names>Shantanu</given-names>
</name>
<xref ref-type="aff" rid="A12">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Getz</surname>
<given-names>Gad</given-names>
</name>
<xref ref-type="aff" rid="A12">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Park</surname>
<given-names>Kwon-Sik</given-names>
</name>
<xref ref-type="aff" rid="A13">13</xref>
<xref ref-type="aff" rid="A14">14</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rauh</surname>
<given-names>Daniel</given-names>
</name>
<xref ref-type="aff" rid="A15">15</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Grütter</surname>
<given-names>Christian</given-names>
</name>
<xref ref-type="aff" rid="A15">15</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fischer</surname>
<given-names>Matthias</given-names>
</name>
<xref ref-type="aff" rid="A16">16</xref>
<xref ref-type="aff" rid="A17">17</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pasqualucci</surname>
<given-names>Laura</given-names>
</name>
<xref ref-type="aff" rid="A18">18</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wright</surname>
<given-names>Gavin</given-names>
</name>
<xref ref-type="aff" rid="A19">19</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wainer</surname>
<given-names>Zoe</given-names>
</name>
<xref ref-type="aff" rid="A19">19</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Russell</surname>
<given-names>Prudence</given-names>
</name>
<xref ref-type="aff" rid="A20">20</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Petersen</surname>
<given-names>Iver</given-names>
</name>
<xref ref-type="aff" rid="A21">21</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chen</surname>
<given-names>Yuan</given-names>
</name>
<xref ref-type="aff" rid="A21">21</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Stoelben</surname>
<given-names>Erich</given-names>
</name>
<xref ref-type="aff" rid="A22">22</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ludwig</surname>
<given-names>Corinna</given-names>
</name>
<xref ref-type="aff" rid="A22">22</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schnabel</surname>
<given-names>Philipp</given-names>
</name>
<xref ref-type="aff" rid="A23">23</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hoffmann</surname>
<given-names>Hans</given-names>
</name>
<xref ref-type="aff" rid="A24">24</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Muley</surname>
<given-names>Thomas</given-names>
</name>
<xref ref-type="aff" rid="A24">24</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Brockmann</surname>
<given-names>Michael</given-names>
</name>
<xref ref-type="aff" rid="A25">25</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Engel-Riedel</surname>
<given-names>Walburga</given-names>
</name>
<xref ref-type="aff" rid="A22">22</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Muscarella</surname>
<given-names>Lucia A</given-names>
</name>
<xref ref-type="aff" rid="A26">26</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fazio</surname>
<given-names>Vito M</given-names>
</name>
<xref ref-type="aff" rid="A26">26</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Groen</surname>
<given-names>Harry</given-names>
</name>
<xref ref-type="aff" rid="A27">27</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Timens</surname>
<given-names>Wim</given-names>
</name>
<xref ref-type="aff" rid="A28">28</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sietsma</surname>
<given-names>Hannie</given-names>
</name>
<xref ref-type="aff" rid="A28">28</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Thunnissen</surname>
<given-names>Erik</given-names>
</name>
<xref ref-type="aff" rid="A29">29</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Smit</surname>
<given-names>Egbert</given-names>
</name>
<xref ref-type="aff" rid="A30">30</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Heideman</surname>
<given-names>Daniëlle AM</given-names>
</name>
<xref ref-type="aff" rid="A29">29</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Snijders</surname>
<given-names>Peter JF</given-names>
</name>
<xref ref-type="aff" rid="A29">29</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cappuzzo</surname>
<given-names>Federico</given-names>
</name>
<xref ref-type="aff" rid="A31">31</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ligorio</surname>
<given-names>Claudia</given-names>
</name>
<xref ref-type="aff" rid="A32">32</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Damiani</surname>
<given-names>Stefania</given-names>
</name>
<xref ref-type="aff" rid="A32">32</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Field</surname>
<given-names>John</given-names>
</name>
<xref ref-type="aff" rid="A33">33</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Solberg</surname>
<given-names>Steinar</given-names>
</name>
<xref ref-type="aff" rid="A34">34</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Brustugun</surname>
<given-names>Odd Terje</given-names>
</name>
<xref ref-type="aff" rid="A35">35</xref>
<xref ref-type="aff" rid="A36">36</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lund-Iversen</surname>
<given-names>Marius</given-names>
</name>
<xref ref-type="aff" rid="A37">37</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sänger</surname>
<given-names>Jörg</given-names>
</name>
<xref ref-type="aff" rid="A38">38</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Clement</surname>
<given-names>Joachim H</given-names>
</name>
<xref ref-type="aff" rid="A39">39</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Soltermann</surname>
<given-names>Alex</given-names>
</name>
<xref ref-type="aff" rid="A40">40</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Moch</surname>
<given-names>Holger</given-names>
</name>
<xref ref-type="aff" rid="A40">40</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Weder</surname>
<given-names>Walter</given-names>
</name>
<xref ref-type="aff" rid="A41">41</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Solomon</surname>
<given-names>Benjamin</given-names>
</name>
<xref ref-type="aff" rid="A42">42</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Soria</surname>
<given-names>Jean-Charles</given-names>
</name>
<xref ref-type="aff" rid="A43">43</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Validire</surname>
<given-names>Pierre</given-names>
</name>
<xref ref-type="aff" rid="A44">44</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Besse</surname>
<given-names>Benjamin</given-names>
</name>
<xref ref-type="aff" rid="A43">43</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Brambilla</surname>
<given-names>Elisabeth</given-names>
</name>
<xref ref-type="aff" rid="A45">45</xref>
<xref ref-type="aff" rid="A46">46</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Brambilla</surname>
<given-names>Christian</given-names>
</name>
<xref ref-type="aff" rid="A45">45</xref>
<xref ref-type="aff" rid="A46">46</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lantuejoul</surname>
<given-names>Sylvie</given-names>
</name>
<xref ref-type="aff" rid="A45">45</xref>
<xref ref-type="aff" rid="A46">46</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lorimier</surname>
<given-names>Philippe</given-names>
</name>
<xref ref-type="aff" rid="A45">45</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schneider</surname>
<given-names>Peter M</given-names>
</name>
<xref ref-type="aff" rid="A47">47</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hallek</surname>
<given-names>Michael</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pao</surname>
<given-names>William</given-names>
</name>
<xref ref-type="aff" rid="A48">48</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Meyerson</surname>
<given-names>Matthew</given-names>
</name>
<xref ref-type="aff" rid="A12">12</xref>
<xref ref-type="aff" rid="A49">49</xref>
<xref ref-type="aff" rid="A50">50</xref>
<xref ref-type="aff" rid="A51">51</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sage</surname>
<given-names>Julien</given-names>
</name>
<xref ref-type="aff" rid="A13">13</xref>
<xref ref-type="aff" rid="A14">14</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Shendure</surname>
<given-names>Jay</given-names>
</name>
<xref ref-type="aff" rid="A52">52</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schneider</surname>
<given-names>Robert</given-names>
</name>
<xref ref-type="aff" rid="A8">8</xref>
<xref ref-type="aff" rid="A53">53</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Büttner</surname>
<given-names>Reinhard</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
<xref ref-type="aff" rid="A9">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wolf</surname>
<given-names>Jürgen</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nürnberg</surname>
<given-names>Peter</given-names>
</name>
<xref ref-type="aff" rid="A10">10</xref>
<xref ref-type="aff" rid="A17">17</xref>
<xref ref-type="aff" rid="A54">54</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Perner</surname>
<given-names>Sven</given-names>
</name>
<xref ref-type="aff" rid="A7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Heukamp</surname>
<given-names>Lukas C</given-names>
</name>
<xref ref-type="aff" rid="A9">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Brindle</surname>
<given-names>Paul K</given-names>
</name>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Haas</surname>
<given-names>Stefan</given-names>
</name>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Thomas</surname>
<given-names>Roman K</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A3">3</xref>
<xref ref-type="aff" rid="A4">4</xref>
<xref ref-type="aff" rid="A9">9</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne, Germany</aff>
<aff id="A2"><label>2</label>
Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931 Cologne, Germany</aff>
<aff id="A3"><label>3</label>
Department I of Internal Medicine and Center of Integrated Oncology Köln-Bonn, University of Cologne, 50924 Cologne, Germany</aff>
<aff id="A4"><label>4</label>
Laboratory of Translational Cancer Genomics, Center of Integrated Oncology Köln – Bonn, University of Cologne, 50924 Cologne, Germany</aff>
<aff id="A5"><label>5</label>
Department of Biochemistry, St Jude Children’s Research Hospital, Memphis, Tennessee 38105, USA</aff>
<aff id="A6"><label>6</label>
Max Planck Institute for Molecular Genetics, Ihnestr. 73, 14194 Berlin, Germany</aff>
<aff id="A7"><label>7</label>
Institute of Prostate Cancer Research at the Institute of Pathology, University Hospital of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany</aff>
<aff id="A8"><label>8</label>
Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany</aff>
<aff id="A9"><label>9</label>
Department of Pathology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany</aff>
<aff id="A10"><label>10</label>
Cologne Center for Genomics, University of Cologne, Cologne, Germany</aff>
<aff id="A11"><label>11</label>
Center for Medical Genetics, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium</aff>
<aff id="A12"><label>12</label>
The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA</aff>
<aff id="A13"><label>13</label>
Department of Pediatrics, Stanford University, Stanford, California, USA</aff>
<aff id="A14"><label>14</label>
Department of Genetics, Stanford University, Stanford, California, USA</aff>
<aff id="A15"><label>15</label>
Technical University Dortmund, Department of Chemical Biology, Otto-Hahn-Str. 6, 44227 Dortmund, Germany</aff>
<aff id="A16"><label>16</label>
Department of Pediatric Oncology and Hematology, University Children’s Hospital of Cologne, Germany</aff>
<aff id="A17"><label>17</label>
Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany</aff>
<aff id="A18"><label>18</label>
Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA</aff>
<aff id="A19"><label>19</label>
The University of Melbourne Department of Surgery, St Vincent’s Hospital, Level 2, Clinical Sciences Building 29 Regent Street, Melbourne, 3065 Victoria, Australia</aff>
<aff id="A20"><label>20</label>
Department of Pathology, St. Vincent’s Hospital, Melbourne, 3065 Victoria, Australia</aff>
<aff id="A21"><label>21</label>
Institute of Pathology, Jena University Hospital, Friedrich-Schiller-University, 07743 Jena, Germany</aff>
<aff id="A22"><label>22</label>
Thoracic Surgery, Lungenklinik Merheim, Kliniken der Stadt Köln gGmbH, 51109 Cologne, Germany</aff>
<aff id="A23"><label>23</label>
Institute of Pathology, Im Neuenheimer Feld 220, 69120 Heidelberg, Germany</aff>
<aff id="A24"><label>24</label>
Thoraxklinik-Heidelberg gGmbH, Amalienstr. 5, 69126 Heidelberg, Germany</aff>
<aff id="A25"><label>25</label>
Department of Pathology, Hospital Merheim, Kliniken der Stadt Köln gGmbH, 51109 Cologne, Germany</aff>
<aff id="A26"><label>26</label>
Laboratory of Oncology, IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini, 71013 San Giovanni Rotondo, Italy</aff>
<aff id="A27"><label>27</label>
Department of Pulmonary Diseases, University Medical Centre Groningen, 9713 GZ Groningen, Netherlands</aff>
<aff id="A28"><label>28</label>
Department of Pathology, University Medical Centre Groningen, 9713 GZ Groningen, Netherlands</aff>
<aff id="A29"><label>29</label>
Department of Pathology, VU University Medical Center Amsterdam, 1007 MB Amsterdam, Netherlands</aff>
<aff id="A30"><label>30</label>
Department of Pulmonary Diseases, VU University Medical Center Amsterdam, 1007 MB Amsterdam, Netherlands</aff>
<aff id="A31"><label>31</label>
Department of Medical Oncology, Ospedale Civile, 57100 Livorno, Italy</aff>
<aff id="A32"><label>32</label>
Department of Haematology and Oncologic Science, University Hospital Bologna, 40138 Bologna, Italy</aff>
<aff id="A33"><label>33</label>
Roy Castle Lung Cancer Research Programme, The University of Liverpool Cancer Research Centre, School of Cancer Studies, University of Liverpool Cancer Research Centre, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, The University of Liverpool. 200 London Road, Liverpool, L3 9TA, UK</aff>
<aff id="A34"><label>34</label>
Department of Thoracic Surgery, Rikshospitalet, Oslo University Hospital, 0027 Oslo, Norway</aff>
<aff id="A35"><label>35</label>
Inst of clinical medicine, Faculty of medicine, University of Oslo, N-0424 Oslo, Norway</aff>
<aff id="A36"><label>36</label>
Dept of oncology, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo, Norway</aff>
<aff id="A37"><label>37</label>
Dept of pathology, Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo, Norway</aff>
<aff id="A38"><label>38</label>
Institute for Pathology Bad Berka, 99438 Bad Berka, Germany</aff>
<aff id="A39"><label>39</label>
Department for Internal Medicine II, Jena University Hospital, Friedrich-Schiller University, 07740 Jena, Germany</aff>
<aff id="A40"><label>40</label>
Institute for Surgical Pathology, University Hospital Zurich, 8091 Zurich, Switzerland</aff>
<aff id="A41"><label>41</label>
Division of Thoracic Surgery, University Hospital Zurich, 8091 Zurich, Switzerland</aff>
<aff id="A42"><label>42</label>
Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, 3002 Victoria, Australia</aff>
<aff id="A43"><label>43</label>
Phase I Unit–Department of Medicine, Institute Gustave Roussy, 39 Rue Camille Desmoulins, 94800 Villejuif, France</aff>
<aff id="A44"><label>44</label>
France Service d’Anatomie-Pathologie, Institut Mutualiste Montsouris, 75014 Paris, France</aff>
<aff id="A45"><label>45</label>
Department of Pathology, Université Joseph Fourier, 38041 Grenoble, France</aff>
<aff id="A46"><label>46</label>
Institut Albert Bonniot INSERM U823, Université Joseph Fourier, 38042 Grenoble, France</aff>
<aff id="A47"><label>47</label>
Institute of Legal Medicine, University of Cologne, Melatengürtel 60/62, 50823 Cologne, Germany</aff>
<aff id="A48"><label>48</label>
Vanderbilt-Ingram Cancer Center, Nashville, TN, USA</aff>
<aff id="A49"><label>49</label>
Harvard Medical School, Boston, Massachusetts 02115, USA</aff>
<aff id="A50"><label>50</label>
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA</aff>
<aff id="A51"><label>51</label>
Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA</aff>
<aff id="A52"><label>52</label>
University of Washington, Department of Genome Sciences, Foege Building S- 250, Box 355065, 3720 15th Ave NE, Seattle, WA 98195-5065, USA</aff>
<aff id="A53"><label>53</label>
Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR 7104, INSERM U 964, Université de Strasbourg, 67404 Illkirch, France</aff>
<aff id="A54"><label>54</label>
Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany</aff>
<author-notes><corresp id="FN1">Correspondence to: Roman Thomas, <email>roman.thomas@uni-koeln.de</email>
, Department of Translational Genomics, University of Cologne, Weyertal 115b, 50931 Cologne, Germany, Tel.: +49-221-478-98771</corresp>
<fn id="FN2" fn-type="equal"><label>*</label>
<p>These authors contributed equally to this work.</p>
</fn>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>11</day>
<month>6</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub"><day>02</day>
<month>9</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="ppub"><month>10</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>21</day>
<month>6</month>
<year>2016</year>
</pub-date>
<volume>44</volume>
<issue>10</issue>
<fpage>1104</fpage>
<lpage>1110</lpage>
<pmc-comment>elocation-id from pubmed: 10.1038/ng.2396</pmc-comment>
<abstract><p id="P1">Small-cell lung cancer (SCLC) is an aggressive lung tumor subtype with poor survival<sup><xref rid="R1" ref-type="bibr">1</xref>
–<xref rid="R3" ref-type="bibr">3</xref>
</sup>
. We sequenced 29 SCLC exomes, two genomes and 15 transcriptomes and found an extremely high mutation rate of 7.4±1 protein-changing mutations per million basepairs. Therefore, we conducted integrated analyses of the various data sets to identify pathogenetically relevant mutated genes. In all cases we found evidence for inactivation of <italic>TP53</italic>
and <italic>RB1</italic>
and identified recurrent mutations in histone-modifying genes, <italic>CREBBP</italic>
, <italic>EP300</italic>
, and <italic>MLL</italic>
. Furthermore, we observed mutations in <italic>PTEN</italic>
, in <italic>SLIT2</italic>
, and <italic>EPHA7</italic>
, as well as focal amplifications of the <italic>FGFR1</italic>
tyrosine kinase gene. Finally, we detected many of the alterations found in humans in SCLC tumors from <italic>p53/Rb1</italic>
-deficient mice<sup><xref rid="R4" ref-type="bibr">4</xref>
</sup>
. Our study implicates histone modification as a major feature of SCLC, reveals potentially therapeutically tractable genome alterations, and provides a generalizable framework for identification of biologically relevant genes in the context of high mutational background.</p>
</abstract>
<kwd-group><kwd>small-cell lung cancer</kwd>
<kwd>cancer genome</kwd>
<kwd>integrated analysis</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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