Genetic predisposition to ductal carcinoma in situ of the breast
Identifieur interne : 000B18 ( Pmc/Curation ); précédent : 000B17; suivant : 000B19Genetic predisposition to ductal carcinoma in situ of the breast
Auteurs : Christos Petridis [Royaume-Uni] ; Mark N. Brook [Royaume-Uni] ; Vandna Shah [Royaume-Uni] ; Kelly Kohut [Royaume-Uni] ; Patricia Gorman [Royaume-Uni] ; Michele Caneppele [Royaume-Uni] ; Dina Levi [Royaume-Uni] ; Efterpi Papouli [Royaume-Uni] ; Nick Orr [Royaume-Uni] ; Angela Cox [Royaume-Uni] ; Simon S. Cross [Royaume-Uni] ; Isabel Dos-Santos-Silva [Royaume-Uni] ; Julian Peto [Royaume-Uni] ; Anthony Swerdlow [Royaume-Uni] ; Minouk J. Schoemaker [Royaume-Uni] ; Manjeet K. Bolla [Royaume-Uni] ; Qin Wang [Royaume-Uni] ; Joe Dennis [Royaume-Uni] ; Kyriaki Michailidou [Royaume-Uni] ; Javier Benitez [Espagne] ; Anna González-Neira [Espagne] ; Daniel C. Tessier [Canada] ; Daniel Vincent [Canada] ; Jingmei Li [Suède] ; Jonine Figueroa [États-Unis] ; Vessela Kristensen [Norvège] ; Anne-Lise Borresen-Dale [Norvège] ; Penny Soucy [Canada] ; Jacques Simard [Canada] ; Roger L. Milne [Australie] ; Graham G. Giles [Australie] ; Sara Margolin [Suède] ; Annika Lindblom [Suède] ; Thomas Brüning [Allemagne] ; Hiltrud Brauch [Allemagne] ; Melissa C. Southey [Australie] ; John L. Hopper [Australie] ; Thilo Dörk [Allemagne] ; Natalia V. Bogdanova [Allemagne] ; Maria Kabisch [Allemagne] ; Ute Hamann [Allemagne] ; Rita K. Schmutzler [Allemagne] ; Alfons Meindl [Allemagne] ; Hermann Brenner [Allemagne] ; Volker Arndt [Allemagne] ; Robert Winqvist [Finlande] ; Katri Pylk S [Finlande] ; Peter A. Fasching [Allemagne, États-Unis] ; Matthias W. Beckmann [Allemagne] ; Jan Lubinski [Pologne] ; Anna Jakubowska [Pologne] ; Anna Marie Mulligan [Canada] ; Irene L. Andrulis [Canada] ; Rob A. E. M. Tollenaar [Pays-Bas] ; Peter Devilee [Pays-Bas] ; Loic Le Marchand [États-Unis] ; Christopher A. Haiman [États-Unis] ; Arto Mannermaa [Finlande] ; Veli-Matti Kosma [Finlande] ; Paolo Radice [Italie] ; Paolo Peterlongo [Italie] ; Frederik Marme [Allemagne] ; Barbara Burwinkel [Allemagne] ; Carolien H. M. Van Deurzen [Pays-Bas] ; Antoinette Hollestelle [Pays-Bas] ; Nicola Miller [Irlande (pays)] ; Michael J. Kerin [Irlande (pays)] ; Diether Lambrechts [Belgique] ; Giuseppe Floris [Belgique] ; Jelle Wesseling [Pays-Bas] ; Henrik Flyger [Danemark] ; Stig E. Bojesen [Danemark] ; Song Yao [États-Unis] ; Christine B. Ambrosone [États-Unis] ; Georgia Chenevix-Trench [Australie] ; Thérèse Truong [France] ; Pascal Guénel [France] ; Anja Rudolph [Allemagne] ; Jenny Chang-Claude [Allemagne] ; Heli Nevanlinna [Finlande] ; Carl Blomqvist [Finlande] ; Kamila Czene [Suède] ; Judith S. Brand [Suède] ; Janet E. Olson [États-Unis] ; Fergus J. Couch [États-Unis] ; Alison M. Dunning [Royaume-Uni] ; Per Hall [Suède] ; Douglas F. Easton [Royaume-Uni] ; Paul D. P. Pharoah [Royaume-Uni] ; Sarah E. Pinder [Royaume-Uni] ; Marjanka K. Schmidt [Pays-Bas] ; Ian Tomlinson [Royaume-Uni] ; Rebecca Roylance [Royaume-Uni] ; Montserrat García-Closas [Royaume-Uni, États-Unis] ; Elinor J. Sawyer [Royaume-Uni]Source :
- Breast Cancer Research : BCR [ 1465-5411 ] ; 2016.
Abstract
Ductal carcinoma
To identify genetic polymorphisms that predispose to DCIS, we pooled data from 38 studies comprising 5,067 cases of DCIS, 24,584 cases of IDC and 37,467 controls, all genotyped using the iCOGS chip.
Most (67 %) of the 76 known breast cancer predisposition loci showed an association with DCIS in the same direction as previously reported for invasive breast cancer. Case-only analysis showed no evidence for differences between associations for IDC and DCIS after considering multiple testing.
Analysis by estrogen receptor (ER) status confirmed that loci associated with ER positive IDC were also associated with ER positive DCIS. Analysis of DCIS by grade suggested that two independent SNPs at 11q13.3 near
We found no novel DCIS-specific loci at a genome wide significance level of
In conclusion, this study provides the strongest evidence to date of a shared genetic susceptibility for IDC and DCIS. Studies with larger numbers of DCIS are needed to determine if IDC or DCIS specific loci exist.
The online version of this article (doi:10.1186/s13058-016-0675-7) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s13058-016-0675-7
PubMed: 26884359
PubMed Central: 4756509
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Cross</name><affiliation wicri:level="1"><nlm:aff id="Aff8">Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield</wicri:regionArea></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name><affiliation wicri:level="1"><nlm:aff id="Aff9">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London</wicri:regionArea></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation wicri:level="1"><nlm:aff id="Aff9">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London</wicri:regionArea></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Genetics and Epidemiology, The Institute of Cancer Research, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff10">Division of Breast Cancer Research, The Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Breast Cancer Research, The Institute of Cancer Research, London</wicri:regionArea></affiliation></author><author><name sortKey="Schoemaker, Minouk J" sort="Schoemaker, Minouk J" uniqKey="Schoemaker M" first="Minouk J." last="Schoemaker">Minouk J. Schoemaker</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Genetics and Epidemiology, The Institute of Cancer Research, London</wicri:regionArea></affiliation></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name><affiliation wicri:level="1"><nlm:aff id="Aff11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation wicri:level="1"><nlm:aff id="Aff11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation wicri:level="1"><nlm:aff id="Aff11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation wicri:level="1"><nlm:aff id="Aff11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation wicri:level="1"><nlm:aff id="Aff12">Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff13">Centro de Investigación en Red de Enfermedades Raras, Valencia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación en Red de Enfermedades Raras, Valencia</wicri:regionArea></affiliation></author><author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name><affiliation wicri:level="1"><nlm:aff id="Aff12">Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Tessier, Daniel C" sort="Tessier, Daniel C" uniqKey="Tessier D" first="Daniel C." last="Tessier">Daniel C. Tessier</name><affiliation wicri:level="1"><nlm:aff id="Aff14">Centre d’innovation Génome Québec et Université McGill, Montréal, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre d’innovation Génome Québec et Université McGill, Montréal</wicri:regionArea></affiliation></author><author><name sortKey="Vincent, Daniel" sort="Vincent, Daniel" uniqKey="Vincent D" first="Daniel" last="Vincent">Daniel Vincent</name><affiliation wicri:level="1"><nlm:aff id="Aff14">Centre d’innovation Génome Québec et Université McGill, Montréal, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre d’innovation Génome Québec et Université McGill, Montréal</wicri:regionArea></affiliation></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name><affiliation wicri:level="1"><nlm:aff id="Aff15">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name><affiliation wicri:level="2"><nlm:aff id="Aff16">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville</wicri:cityArea></affiliation></author><author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name><affiliation wicri:level="1"><nlm:aff id="Aff17">Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff18">K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff19">Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo</wicri:regionArea></affiliation></author><author><name sortKey="Borresen Dale, Anne Lise" sort="Borresen Dale, Anne Lise" uniqKey="Borresen Dale A" first="Anne-Lise" last="Borresen-Dale">Anne-Lise Borresen-Dale</name><affiliation wicri:level="1"><nlm:aff id="Aff17">Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff18">K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo</wicri:regionArea></affiliation></author><author><name sortKey="Soucy, Penny" sort="Soucy, Penny" uniqKey="Soucy P" first="Penny" last="Soucy">Penny Soucy</name><affiliation wicri:level="1"><nlm:aff id="Aff20">Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City</wicri:regionArea></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation wicri:level="1"><nlm:aff id="Aff20">Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City</wicri:regionArea></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation wicri:level="1"><nlm:aff id="Aff21">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne</wicri:regionArea></affiliation><affiliation wicri:level="4"><nlm:aff id="Aff22">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne, VIC Australia</nlm:aff><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation wicri:level="1"><nlm:aff id="Aff21">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne</wicri:regionArea></affiliation><affiliation wicri:level="4"><nlm:aff id="Aff22">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne, VIC Australia</nlm:aff><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation wicri:level="1"><nlm:aff id="Aff23">Department of Oncology - Pathology, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Oncology - Pathology, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation wicri:level="1"><nlm:aff id="Aff24">Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name><affiliation wicri:level="1"><nlm:aff id="Aff25">Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum</wicri:regionArea></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation wicri:level="1"><nlm:aff id="Aff26">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff27">University of Tübingen, Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Tübingen, Tübingen</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff28">German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation wicri:level="1"><nlm:aff id="Aff29">Department of Pathology, The University of Melbourne, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Pathology, The University of Melbourne, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation wicri:level="4"><nlm:aff id="Aff22">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne, VIC Australia</nlm:aff><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation wicri:level="1"><nlm:aff id="Aff30">Gynaecology Research Unit, Hannover Medical School, Hannover, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Gynaecology Research Unit, Hannover Medical School, Hannover</wicri:regionArea></affiliation></author><author><name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V." last="Bogdanova">Natalia V. Bogdanova</name><affiliation wicri:level="1"><nlm:aff id="Aff31">Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Radiation Oncology, Hannover Medical School, Hannover</wicri:regionArea></affiliation></author><author><name sortKey="Kabisch, Maria" sort="Kabisch, Maria" uniqKey="Kabisch M" first="Maria" last="Kabisch">Maria Kabisch</name><affiliation wicri:level="1"><nlm:aff id="Aff32">Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation wicri:level="1"><nlm:aff id="Aff32">Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation wicri:level="1"><nlm:aff id="Aff33">Center for Familial Breast and Ovarian Cancer, Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Familial Breast and Ovarian Cancer, Medical Faculty, University of Cologne and University Hospital Cologne, Cologne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff34">Center for Integrated Oncology (CIO), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Integrated Oncology (CIO), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff35">Center for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne</wicri:regionArea></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation wicri:level="1"><nlm:aff id="Aff36">Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Gynaecology and Obstetrics, Technische Universität München, Munich</wicri:regionArea></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="1"><nlm:aff id="Aff28">German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff37">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff38">Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation wicri:level="1"><nlm:aff id="Aff37">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation wicri:level="1"><nlm:aff id="Aff39">Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff40">Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu</wicri:regionArea></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation wicri:level="1"><nlm:aff id="Aff39">Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff40">Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu</wicri:regionArea></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation wicri:level="1"><nlm:aff id="Aff41">Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen</wicri:regionArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff42">David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation wicri:level="1"><nlm:aff id="Aff41">Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen</wicri:regionArea></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation wicri:level="1"><nlm:aff id="Aff43">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation wicri:level="1"><nlm:aff id="Aff43">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea></affiliation></author><author><name sortKey="Mulligan, Anna Marie" sort="Mulligan, Anna Marie" uniqKey="Mulligan A" first="Anna Marie" last="Mulligan">Anna Marie Mulligan</name><affiliation wicri:level="1"><nlm:aff id="Aff44">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff45">Laboratory Medicine Program, University Health Network, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Laboratory Medicine Program, University Health Network, Toronto</wicri:regionArea></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation wicri:level="1"><nlm:aff id="Aff46">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff47">Department of Molecular Genetics, University of Toronto, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Molecular Genetics, University of Toronto, Toronto</wicri:regionArea></affiliation></author><author><name sortKey="Tollenaar, Rob A E M" sort="Tollenaar, Rob A E M" uniqKey="Tollenaar R" first="Rob A. E. M." last="Tollenaar">Rob A. E. M. Tollenaar</name><affiliation wicri:level="1"><nlm:aff id="Aff48">Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Surgery, Leiden University Medical Center, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation wicri:level="1"><nlm:aff id="Aff49">Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, Leiden University Medical Center, Leiden</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff50">Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Human Genetics, Leiden University Medical Center, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation wicri:level="2"><nlm:aff id="Aff51">University of Hawaii Cancer Center, Honolulu, HI USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>University of Hawaii Cancer Center, Honolulu</wicri:cityArea></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation wicri:level="2"><nlm:aff id="Aff52">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation wicri:level="1"><nlm:aff id="Aff53">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff54">Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff55">Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio</wicri:regionArea></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation wicri:level="1"><nlm:aff id="Aff53">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff54">Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff55">Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio</wicri:regionArea></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation wicri:level="1"><nlm:aff id="Aff56">Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan</wicri:regionArea></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation wicri:level="1"><nlm:aff id="Aff57">IFOM, Fondazione Istituto FIRC (Italian Foundation of Cancer Research) di Oncologia Molecolare, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IFOM, Fondazione Istituto FIRC (Italian Foundation of Cancer Research) di Oncologia Molecolare, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name><affiliation wicri:level="1"><nlm:aff id="Aff58">National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>National Center for Tumor Diseases, University of Heidelberg, Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff59">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation wicri:level="1"><nlm:aff id="Aff59">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff60">Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Van Deurzen, Carolien H M" sort="Van Deurzen, Carolien H M" uniqKey="Van Deurzen C" first="Carolien H. M." last="Van Deurzen">Carolien H. M. Van Deurzen</name><affiliation wicri:level="1"><nlm:aff id="Aff61">Department of Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name><affiliation wicri:level="1"><nlm:aff id="Aff62">Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name><affiliation wicri:level="1"><nlm:aff id="Aff63">School of Medicine, National University of Ireland, Galway, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>School of Medicine, National University of Ireland, Galway</wicri:regionArea></affiliation></author><author><name sortKey="Kerin, Michael J" sort="Kerin, Michael J" uniqKey="Kerin M" first="Michael J." last="Kerin">Michael J. Kerin</name><affiliation wicri:level="1"><nlm:aff id="Aff63">School of Medicine, National University of Ireland, Galway, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>School of Medicine, National University of Ireland, Galway</wicri:regionArea></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation wicri:level="1"><nlm:aff id="Aff64">Vesalius Research Center, VIB, Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Vesalius Research Center, VIB, Leuven</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff65">Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven</wicri:regionArea></affiliation></author><author><name sortKey="Floris, Giuseppe" sort="Floris, Giuseppe" uniqKey="Floris G" first="Giuseppe" last="Floris">Giuseppe Floris</name><affiliation wicri:level="1"><nlm:aff id="Aff66">University Hospital Gashuisberg, Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>University Hospital Gashuisberg, Leuven</wicri:regionArea></affiliation></author><author><name sortKey="Wesseling, Jelle" sort="Wesseling, Jelle" uniqKey="Wesseling J" first="Jelle" last="Wesseling">Jelle Wesseling</name><affiliation wicri:level="1"><nlm:aff id="Aff67">Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation wicri:level="1"><nlm:aff id="Aff68">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev</wicri:regionArea></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation wicri:level="1"><nlm:aff id="Aff69">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff70">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff71">Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Yao, Song" sort="Yao, Song" uniqKey="Yao S" first="Song" last="Yao">Song Yao</name><affiliation wicri:level="2"><nlm:aff id="Aff72">Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY USA</nlm:aff><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo</wicri:cityArea></affiliation></author><author><name sortKey="Ambrosone, Christine B" sort="Ambrosone, Christine B" uniqKey="Ambrosone C" first="Christine B." last="Ambrosone">Christine B. Ambrosone</name><affiliation wicri:level="2"><nlm:aff id="Aff73">Roswell Park Cancer Institute, Buffalo, NY USA</nlm:aff><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Roswell Park Cancer Institute, Buffalo</wicri:cityArea></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation wicri:level="1"><nlm:aff id="Aff74">Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation wicri:level="1"><nlm:aff id="Aff75">Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff76">University Paris-Sud, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Paris-Sud, Villejuif</wicri:regionArea></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation wicri:level="1"><nlm:aff id="Aff75">Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff76">University Paris-Sud, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Paris-Sud, Villejuif</wicri:regionArea></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation wicri:level="1"><nlm:aff id="Aff77">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation wicri:level="1"><nlm:aff id="Aff77">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation wicri:level="1"><nlm:aff id="Aff78">Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation wicri:level="1"><nlm:aff id="Aff79">Department of Oncology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Oncology, Helsinki University Hospital, University of Helsinki, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation wicri:level="1"><nlm:aff id="Aff15">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Brand, Judith S" sort="Brand, Judith S" uniqKey="Brand J" first="Judith S." last="Brand">Judith S. Brand</name><affiliation wicri:level="1"><nlm:aff id="Aff15">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name><affiliation wicri:level="2"><nlm:aff id="Aff80">Department of Health Sciences Research, Mayo Clinic, Rochester, MN USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Health Sciences Research, Mayo Clinic, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation wicri:level="2"><nlm:aff id="Aff81">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation wicri:level="1"><nlm:aff id="Aff82">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation wicri:level="1"><nlm:aff id="Aff15">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation wicri:level="1"><nlm:aff id="Aff11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff82">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name><affiliation wicri:level="1"><nlm:aff id="Aff11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff82">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Pinder, Sarah E" sort="Pinder, Sarah E" uniqKey="Pinder S" first="Sarah E." last="Pinder">Sarah E. Pinder</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Research Oncology, Guy’s Hospital, King’s College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Research Oncology, Guy’s Hospital, King’s College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K" last="Schmidt">Marjanka K. Schmidt</name><affiliation wicri:level="1"><nlm:aff id="Aff67">Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation wicri:level="1"><nlm:aff id="Aff83">Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Roylance, Rebecca" sort="Roylance, Rebecca" uniqKey="Roylance R" first="Rebecca" last="Roylance">Rebecca Roylance</name><affiliation wicri:level="1"><nlm:aff id="Aff4">Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London</wicri:regionArea></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Genetics and Epidemiology, The Institute of Cancer Research, London</wicri:regionArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff16">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville</wicri:cityArea></affiliation></author><author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J." last="Sawyer">Elinor J. Sawyer</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Research Oncology, Guy’s Hospital, King’s College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Research Oncology, Guy’s Hospital, King’s College London, London</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26884359</idno><idno type="pmc">4756509</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756509</idno><idno type="RBID">PMC:4756509</idno><idno type="doi">10.1186/s13058-016-0675-7</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000B41</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000B41</idno><idno type="wicri:Area/Pmc/Curation">000B18</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000B18</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genetic predisposition to ductal carcinoma <italic>in situ</italic> of the breast</title><author><name sortKey="Petridis, Christos" sort="Petridis, Christos" uniqKey="Petridis C" first="Christos" last="Petridis">Christos Petridis</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Research Oncology, Guy’s Hospital, King’s College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Research Oncology, Guy’s Hospital, King’s College London, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2">Medical and Molecular Genetics, Guy’s Hospital, King’s College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical and Molecular Genetics, Guy’s Hospital, King’s College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Brook, Mark N" sort="Brook, Mark N" uniqKey="Brook M" first="Mark N." last="Brook">Mark N. Brook</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Genetics and Epidemiology, The Institute of Cancer Research, London</wicri:regionArea></affiliation></author><author><name sortKey="Shah, Vandna" sort="Shah, Vandna" uniqKey="Shah V" first="Vandna" last="Shah">Vandna Shah</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Research Oncology, Guy’s Hospital, King’s College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Research Oncology, Guy’s Hospital, King’s College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Kohut, Kelly" sort="Kohut, Kelly" uniqKey="Kohut K" first="Kelly" last="Kohut">Kelly Kohut</name><affiliation wicri:level="1"><nlm:aff id="Aff4">Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London</wicri:regionArea></affiliation></author><author><name sortKey="Gorman, Patricia" sort="Gorman, Patricia" uniqKey="Gorman P" first="Patricia" last="Gorman">Patricia Gorman</name><affiliation wicri:level="1"><nlm:aff id="Aff4">Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London</wicri:regionArea></affiliation></author><author><name sortKey="Caneppele, Michele" sort="Caneppele, Michele" uniqKey="Caneppele M" first="Michele" last="Caneppele">Michele Caneppele</name><affiliation wicri:level="1"><nlm:aff id="Aff4">Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London</wicri:regionArea></affiliation></author><author><name sortKey="Levi, Dina" sort="Levi, Dina" uniqKey="Levi D" first="Dina" last="Levi">Dina Levi</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Research Oncology, Guy’s Hospital, King’s College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Research Oncology, Guy’s Hospital, King’s College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Papouli, Efterpi" sort="Papouli, Efterpi" uniqKey="Papouli E" first="Efterpi" last="Papouli">Efterpi Papouli</name><affiliation wicri:level="1"><nlm:aff id="Aff5">Biomedical Research Centre, King’s College London, Guy’s Hospital, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Biomedical Research Centre, King’s College London, Guy’s Hospital, London</wicri:regionArea></affiliation></author><author><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name><affiliation wicri:level="1"><nlm:aff id="Aff6">The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London</wicri:regionArea></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation wicri:level="1"><nlm:aff id="Aff7">Sheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield</wicri:regionArea></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name><affiliation wicri:level="1"><nlm:aff id="Aff8">Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield</wicri:regionArea></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name><affiliation wicri:level="1"><nlm:aff id="Aff9">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London</wicri:regionArea></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation wicri:level="1"><nlm:aff id="Aff9">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London</wicri:regionArea></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Genetics and Epidemiology, The Institute of Cancer Research, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff10">Division of Breast Cancer Research, The Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Breast Cancer Research, The Institute of Cancer Research, London</wicri:regionArea></affiliation></author><author><name sortKey="Schoemaker, Minouk J" sort="Schoemaker, Minouk J" uniqKey="Schoemaker M" first="Minouk J." last="Schoemaker">Minouk J. Schoemaker</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Genetics and Epidemiology, The Institute of Cancer Research, London</wicri:regionArea></affiliation></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name><affiliation wicri:level="1"><nlm:aff id="Aff11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation wicri:level="1"><nlm:aff id="Aff11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation wicri:level="1"><nlm:aff id="Aff11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation wicri:level="1"><nlm:aff id="Aff11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation wicri:level="1"><nlm:aff id="Aff12">Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff13">Centro de Investigación en Red de Enfermedades Raras, Valencia, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación en Red de Enfermedades Raras, Valencia</wicri:regionArea></affiliation></author><author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name><affiliation wicri:level="1"><nlm:aff id="Aff12">Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Tessier, Daniel C" sort="Tessier, Daniel C" uniqKey="Tessier D" first="Daniel C." last="Tessier">Daniel C. Tessier</name><affiliation wicri:level="1"><nlm:aff id="Aff14">Centre d’innovation Génome Québec et Université McGill, Montréal, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre d’innovation Génome Québec et Université McGill, Montréal</wicri:regionArea></affiliation></author><author><name sortKey="Vincent, Daniel" sort="Vincent, Daniel" uniqKey="Vincent D" first="Daniel" last="Vincent">Daniel Vincent</name><affiliation wicri:level="1"><nlm:aff id="Aff14">Centre d’innovation Génome Québec et Université McGill, Montréal, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre d’innovation Génome Québec et Université McGill, Montréal</wicri:regionArea></affiliation></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name><affiliation wicri:level="1"><nlm:aff id="Aff15">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name><affiliation wicri:level="2"><nlm:aff id="Aff16">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville</wicri:cityArea></affiliation></author><author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name><affiliation wicri:level="1"><nlm:aff id="Aff17">Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff18">K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff19">Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo</wicri:regionArea></affiliation></author><author><name sortKey="Borresen Dale, Anne Lise" sort="Borresen Dale, Anne Lise" uniqKey="Borresen Dale A" first="Anne-Lise" last="Borresen-Dale">Anne-Lise Borresen-Dale</name><affiliation wicri:level="1"><nlm:aff id="Aff17">Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff18">K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo</wicri:regionArea></affiliation></author><author><name sortKey="Soucy, Penny" sort="Soucy, Penny" uniqKey="Soucy P" first="Penny" last="Soucy">Penny Soucy</name><affiliation wicri:level="1"><nlm:aff id="Aff20">Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City</wicri:regionArea></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation wicri:level="1"><nlm:aff id="Aff20">Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City</wicri:regionArea></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation wicri:level="1"><nlm:aff id="Aff21">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne</wicri:regionArea></affiliation><affiliation wicri:level="4"><nlm:aff id="Aff22">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne, VIC Australia</nlm:aff><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation wicri:level="1"><nlm:aff id="Aff21">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne</wicri:regionArea></affiliation><affiliation wicri:level="4"><nlm:aff id="Aff22">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne, VIC Australia</nlm:aff><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation wicri:level="1"><nlm:aff id="Aff23">Department of Oncology - Pathology, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Oncology - Pathology, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation wicri:level="1"><nlm:aff id="Aff24">Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name><affiliation wicri:level="1"><nlm:aff id="Aff25">Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum</wicri:regionArea></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation wicri:level="1"><nlm:aff id="Aff26">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff27">University of Tübingen, Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Tübingen, Tübingen</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff28">German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation wicri:level="1"><nlm:aff id="Aff29">Department of Pathology, The University of Melbourne, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Pathology, The University of Melbourne, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation wicri:level="4"><nlm:aff id="Aff22">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne, VIC Australia</nlm:aff><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation wicri:level="1"><nlm:aff id="Aff30">Gynaecology Research Unit, Hannover Medical School, Hannover, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Gynaecology Research Unit, Hannover Medical School, Hannover</wicri:regionArea></affiliation></author><author><name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V." last="Bogdanova">Natalia V. Bogdanova</name><affiliation wicri:level="1"><nlm:aff id="Aff31">Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Radiation Oncology, Hannover Medical School, Hannover</wicri:regionArea></affiliation></author><author><name sortKey="Kabisch, Maria" sort="Kabisch, Maria" uniqKey="Kabisch M" first="Maria" last="Kabisch">Maria Kabisch</name><affiliation wicri:level="1"><nlm:aff id="Aff32">Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation wicri:level="1"><nlm:aff id="Aff32">Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation wicri:level="1"><nlm:aff id="Aff33">Center for Familial Breast and Ovarian Cancer, Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Familial Breast and Ovarian Cancer, Medical Faculty, University of Cologne and University Hospital Cologne, Cologne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff34">Center for Integrated Oncology (CIO), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Integrated Oncology (CIO), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff35">Center for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne</wicri:regionArea></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation wicri:level="1"><nlm:aff id="Aff36">Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Gynaecology and Obstetrics, Technische Universität München, Munich</wicri:regionArea></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="1"><nlm:aff id="Aff28">German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff37">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff38">Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation wicri:level="1"><nlm:aff id="Aff37">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation wicri:level="1"><nlm:aff id="Aff39">Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff40">Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu</wicri:regionArea></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation wicri:level="1"><nlm:aff id="Aff39">Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff40">Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu</wicri:regionArea></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation wicri:level="1"><nlm:aff id="Aff41">Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen</wicri:regionArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff42">David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation wicri:level="1"><nlm:aff id="Aff41">Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen</wicri:regionArea></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation wicri:level="1"><nlm:aff id="Aff43">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation wicri:level="1"><nlm:aff id="Aff43">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea></affiliation></author><author><name sortKey="Mulligan, Anna Marie" sort="Mulligan, Anna Marie" uniqKey="Mulligan A" first="Anna Marie" last="Mulligan">Anna Marie Mulligan</name><affiliation wicri:level="1"><nlm:aff id="Aff44">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff45">Laboratory Medicine Program, University Health Network, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Laboratory Medicine Program, University Health Network, Toronto</wicri:regionArea></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation wicri:level="1"><nlm:aff id="Aff46">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff47">Department of Molecular Genetics, University of Toronto, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Molecular Genetics, University of Toronto, Toronto</wicri:regionArea></affiliation></author><author><name sortKey="Tollenaar, Rob A E M" sort="Tollenaar, Rob A E M" uniqKey="Tollenaar R" first="Rob A. E. M." last="Tollenaar">Rob A. E. M. Tollenaar</name><affiliation wicri:level="1"><nlm:aff id="Aff48">Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Surgery, Leiden University Medical Center, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation wicri:level="1"><nlm:aff id="Aff49">Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, Leiden University Medical Center, Leiden</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff50">Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Human Genetics, Leiden University Medical Center, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation wicri:level="2"><nlm:aff id="Aff51">University of Hawaii Cancer Center, Honolulu, HI USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>University of Hawaii Cancer Center, Honolulu</wicri:cityArea></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation wicri:level="2"><nlm:aff id="Aff52">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation wicri:level="1"><nlm:aff id="Aff53">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff54">Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff55">Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio</wicri:regionArea></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation wicri:level="1"><nlm:aff id="Aff53">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff54">Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff55">Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio</wicri:regionArea></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation wicri:level="1"><nlm:aff id="Aff56">Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan</wicri:regionArea></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation wicri:level="1"><nlm:aff id="Aff57">IFOM, Fondazione Istituto FIRC (Italian Foundation of Cancer Research) di Oncologia Molecolare, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IFOM, Fondazione Istituto FIRC (Italian Foundation of Cancer Research) di Oncologia Molecolare, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name><affiliation wicri:level="1"><nlm:aff id="Aff58">National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>National Center for Tumor Diseases, University of Heidelberg, Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff59">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation wicri:level="1"><nlm:aff id="Aff59">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff60">Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Van Deurzen, Carolien H M" sort="Van Deurzen, Carolien H M" uniqKey="Van Deurzen C" first="Carolien H. M." last="Van Deurzen">Carolien H. M. Van Deurzen</name><affiliation wicri:level="1"><nlm:aff id="Aff61">Department of Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, Erasmus University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name><affiliation wicri:level="1"><nlm:aff id="Aff62">Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name><affiliation wicri:level="1"><nlm:aff id="Aff63">School of Medicine, National University of Ireland, Galway, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>School of Medicine, National University of Ireland, Galway</wicri:regionArea></affiliation></author><author><name sortKey="Kerin, Michael J" sort="Kerin, Michael J" uniqKey="Kerin M" first="Michael J." last="Kerin">Michael J. Kerin</name><affiliation wicri:level="1"><nlm:aff id="Aff63">School of Medicine, National University of Ireland, Galway, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>School of Medicine, National University of Ireland, Galway</wicri:regionArea></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation wicri:level="1"><nlm:aff id="Aff64">Vesalius Research Center, VIB, Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Vesalius Research Center, VIB, Leuven</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff65">Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven</wicri:regionArea></affiliation></author><author><name sortKey="Floris, Giuseppe" sort="Floris, Giuseppe" uniqKey="Floris G" first="Giuseppe" last="Floris">Giuseppe Floris</name><affiliation wicri:level="1"><nlm:aff id="Aff66">University Hospital Gashuisberg, Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>University Hospital Gashuisberg, Leuven</wicri:regionArea></affiliation></author><author><name sortKey="Wesseling, Jelle" sort="Wesseling, Jelle" uniqKey="Wesseling J" first="Jelle" last="Wesseling">Jelle Wesseling</name><affiliation wicri:level="1"><nlm:aff id="Aff67">Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation wicri:level="1"><nlm:aff id="Aff68">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev</wicri:regionArea></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation wicri:level="1"><nlm:aff id="Aff69">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff70">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff71">Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Yao, Song" sort="Yao, Song" uniqKey="Yao S" first="Song" last="Yao">Song Yao</name><affiliation wicri:level="2"><nlm:aff id="Aff72">Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY USA</nlm:aff><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo</wicri:cityArea></affiliation></author><author><name sortKey="Ambrosone, Christine B" sort="Ambrosone, Christine B" uniqKey="Ambrosone C" first="Christine B." last="Ambrosone">Christine B. Ambrosone</name><affiliation wicri:level="2"><nlm:aff id="Aff73">Roswell Park Cancer Institute, Buffalo, NY USA</nlm:aff><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Roswell Park Cancer Institute, Buffalo</wicri:cityArea></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation wicri:level="1"><nlm:aff id="Aff74">Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation wicri:level="1"><nlm:aff id="Aff75">Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff76">University Paris-Sud, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Paris-Sud, Villejuif</wicri:regionArea></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation wicri:level="1"><nlm:aff id="Aff75">Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff76">University Paris-Sud, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Paris-Sud, Villejuif</wicri:regionArea></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation wicri:level="1"><nlm:aff id="Aff77">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation wicri:level="1"><nlm:aff id="Aff77">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation wicri:level="1"><nlm:aff id="Aff78">Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation wicri:level="1"><nlm:aff id="Aff79">Department of Oncology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Oncology, Helsinki University Hospital, University of Helsinki, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation wicri:level="1"><nlm:aff id="Aff15">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Brand, Judith S" sort="Brand, Judith S" uniqKey="Brand J" first="Judith S." last="Brand">Judith S. Brand</name><affiliation wicri:level="1"><nlm:aff id="Aff15">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name><affiliation wicri:level="2"><nlm:aff id="Aff80">Department of Health Sciences Research, Mayo Clinic, Rochester, MN USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Health Sciences Research, Mayo Clinic, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation wicri:level="2"><nlm:aff id="Aff81">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation wicri:level="1"><nlm:aff id="Aff82">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation wicri:level="1"><nlm:aff id="Aff15">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation wicri:level="1"><nlm:aff id="Aff11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff82">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name><affiliation wicri:level="1"><nlm:aff id="Aff11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff82">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea></affiliation></author><author><name sortKey="Pinder, Sarah E" sort="Pinder, Sarah E" uniqKey="Pinder S" first="Sarah E." last="Pinder">Sarah E. Pinder</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Research Oncology, Guy’s Hospital, King’s College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Research Oncology, Guy’s Hospital, King’s College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K" last="Schmidt">Marjanka K. Schmidt</name><affiliation wicri:level="1"><nlm:aff id="Aff67">Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation wicri:level="1"><nlm:aff id="Aff83">Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Roylance, Rebecca" sort="Roylance, Rebecca" uniqKey="Roylance R" first="Rebecca" last="Roylance">Rebecca Roylance</name><affiliation wicri:level="1"><nlm:aff id="Aff4">Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London</wicri:regionArea></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Genetics and Epidemiology, The Institute of Cancer Research, London</wicri:regionArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff16">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville</wicri:cityArea></affiliation></author><author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J." last="Sawyer">Elinor J. Sawyer</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Research Oncology, Guy’s Hospital, King’s College London, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Research Oncology, Guy’s Hospital, King’s College London, London</wicri:regionArea></affiliation></author></analytic><series><title level="j">Breast Cancer Research : BCR</title><idno type="ISSN">1465-5411</idno><idno type="eISSN">1465-542X</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Ductal carcinoma <italic>in situ</italic> (DCIS) is a non-invasive form of breast cancer. It is often associated with invasive ductal carcinoma (IDC), and is considered to be a non-obligate precursor of IDC. It is not clear to what extent these two forms of cancer share low-risk susceptibility loci, or whether there are differences in the strength of association for shared loci.</p></sec><sec><title>Methods</title><p>To identify genetic polymorphisms that predispose to DCIS, we pooled data from 38 studies comprising 5,067 cases of DCIS, 24,584 cases of IDC and 37,467 controls, all genotyped using the iCOGS chip.</p></sec><sec><title>Results</title><p>Most (67 %) of the 76 known breast cancer predisposition loci showed an association with DCIS in the same direction as previously reported for invasive breast cancer. Case-only analysis showed no evidence for differences between associations for IDC and DCIS after considering multiple testing.</p><p>Analysis by estrogen receptor (ER) status confirmed that loci associated with ER positive IDC were also associated with ER positive DCIS. Analysis of DCIS by grade suggested that two independent SNPs at 11q13.3 near <italic>CCND1</italic> were specific to low/intermediate grade DCIS (rs75915166, rs554219). These associations with grade remained after adjusting for ER status and were also found in IDC.</p><p>We found no novel DCIS-specific loci at a genome wide significance level of <italic>P</italic> < 5.0x10<sup>-8</sup>.</p></sec><sec><title>Conclusion</title><p>In conclusion, this study provides the strongest evidence to date of a shared genetic susceptibility for IDC and DCIS. Studies with larger numbers of DCIS are needed to determine if IDC or DCIS specific loci exist.</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/s13058-016-0675-7) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Li, Ci" uniqKey="Li C">CI Li</name></author><author><name sortKey="Daling, Jr" uniqKey="Daling J">JR Daling</name></author><author><name sortKey="Malone, Ke" uniqKey="Malone K">KE Malone</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leonard, Gd" uniqKey="Leonard G">GD Leonard</name></author><author><name sortKey="Swain, Sm" uniqKey="Swain S">SM Swain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, H" uniqKey="Wong H">H Wong</name></author><author><name sortKey="Lau, S" uniqKey="Lau S">S 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Breast Cancer Res</journal-id><journal-id journal-id-type="iso-abbrev">Breast Cancer Res</journal-id><journal-title-group><journal-title>Breast Cancer Research : BCR</journal-title></journal-title-group><issn pub-type="ppub">1465-5411</issn><issn pub-type="epub">1465-542X</issn><publisher><publisher-name>BioMed Central</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26884359</article-id><article-id pub-id-type="pmc">4756509</article-id><article-id pub-id-type="publisher-id">675</article-id><article-id pub-id-type="doi">10.1186/s13058-016-0675-7</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Genetic predisposition to ductal carcinoma <italic>in situ</italic> of the breast</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Petridis</surname><given-names>Christos</given-names></name><address><email>christos.petridis@kcl.ac.uk</email></address><xref ref-type="aff" rid="Aff1"></xref><xref ref-type="aff" rid="Aff2"></xref></contrib><contrib contrib-type="author"><name><surname>Brook</surname><given-names>Mark N.</given-names></name><address><email>Mark.Brook@icr.ac.uk</email></address><xref ref-type="aff" rid="Aff3"></xref></contrib><contrib contrib-type="author"><name><surname>Shah</surname><given-names>Vandna</given-names></name><address><email>vandna.shah@kcl.ac.uk</email></address><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Kohut</surname><given-names>Kelly</given-names></name><address><email>kohut.kelly@gmail.com</email></address><xref ref-type="aff" rid="Aff4"></xref></contrib><contrib contrib-type="author"><name><surname>Gorman</surname><given-names>Patricia</given-names></name><address><email>patricia.carlyle@me.com</email></address><xref ref-type="aff" rid="Aff4"></xref></contrib><contrib contrib-type="author"><name><surname>Caneppele</surname><given-names>Michele</given-names></name><address><email>michele.caneppele@novartis.com</email></address><xref ref-type="aff" rid="Aff4"></xref></contrib><contrib contrib-type="author"><name><surname>Levi</surname><given-names>Dina</given-names></name><address><email>dinalevi@gmail.com</email></address><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Papouli</surname><given-names>Efterpi</given-names></name><address><email>efterpi@cegx.co.uk</email></address><xref ref-type="aff" rid="Aff5"></xref></contrib><contrib contrib-type="author"><name><surname>Orr</surname><given-names>Nick</given-names></name><address><email>Nicholas.Orr@icr.ac.uk</email></address><xref ref-type="aff" rid="Aff6"></xref></contrib><contrib contrib-type="author"><name><surname>Cox</surname><given-names>Angela</given-names></name><address><email>a.cox@shef.ac.uk</email></address><xref ref-type="aff" rid="Aff7"></xref></contrib><contrib contrib-type="author"><name><surname>Cross</surname><given-names>Simon S.</given-names></name><address><email>s.s.cross@sheffield.ac.uk</email></address><xref ref-type="aff" rid="Aff8"></xref></contrib><contrib contrib-type="author"><name><surname>dos-Santos-Silva</surname><given-names>Isabel</given-names></name><address><email>isabel.silva@lshtm.ac.uk</email></address><xref ref-type="aff" rid="Aff9"></xref></contrib><contrib contrib-type="author"><name><surname>Peto</surname><given-names>Julian</given-names></name><address><email>Julian.Peto@lshtm.ac.uk</email></address><xref ref-type="aff" rid="Aff9"></xref></contrib><contrib contrib-type="author"><name><surname>Swerdlow</surname><given-names>Anthony</given-names></name><address><email>Anthony.Swerdlow@icr.ac.uk</email></address><xref ref-type="aff" rid="Aff3"></xref><xref ref-type="aff" rid="Aff10"></xref></contrib><contrib contrib-type="author"><name><surname>Schoemaker</surname><given-names>Minouk J.</given-names></name><address><email>minouk.schoemaker@icr.ac.uk</email></address><xref ref-type="aff" rid="Aff3"></xref></contrib><contrib contrib-type="author"><name><surname>Bolla</surname><given-names>Manjeet K.</given-names></name><address><email>mkh39@medschl.cam.ac.uk</email></address><xref ref-type="aff" rid="Aff11"></xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Qin</given-names></name><address><email>qw232@medschl.cam.ac.uk</email></address><xref ref-type="aff" rid="Aff11"></xref></contrib><contrib contrib-type="author"><name><surname>Dennis</surname><given-names>Joe</given-names></name><address><email>jgd29@cam.ac.uk</email></address><xref ref-type="aff" rid="Aff11"></xref></contrib><contrib contrib-type="author"><name><surname>Michailidou</surname><given-names>Kyriaki</given-names></name><address><email>km533@medschl.cam.ac.uk</email></address><xref ref-type="aff" rid="Aff11"></xref></contrib><contrib contrib-type="author"><name><surname>Benitez</surname><given-names>Javier</given-names></name><address><email>jbenitez@cnio.es</email></address><xref ref-type="aff" rid="Aff12"></xref><xref ref-type="aff" rid="Aff13"></xref></contrib><contrib contrib-type="author"><name><surname>González-Neira</surname><given-names>Anna</given-names></name><address><email>agonzalez@cnio.es</email></address><xref ref-type="aff" rid="Aff12"></xref></contrib><contrib contrib-type="author"><name><surname>Tessier</surname><given-names>Daniel 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rid="Aff22"></xref></contrib><contrib contrib-type="author"><name><surname>Giles</surname><given-names>Graham G.</given-names></name><address><email>Graham.Giles@cancervic.org.au</email></address><xref ref-type="aff" rid="Aff21"></xref><xref ref-type="aff" rid="Aff22"></xref></contrib><contrib contrib-type="author"><name><surname>Margolin</surname><given-names>Sara</given-names></name><address><email>Sara.Margolin@karolinska.se</email></address><xref ref-type="aff" rid="Aff23"></xref></contrib><contrib contrib-type="author"><name><surname>Lindblom</surname><given-names>Annika</given-names></name><address><email>Annika.Lindblom@ki.se</email></address><xref ref-type="aff" rid="Aff24"></xref></contrib><contrib contrib-type="author"><name><surname>Brüning</surname><given-names>Thomas</given-names></name><address><email>bruening@ipa-dguv.de</email></address><xref ref-type="aff" rid="Aff25"></xref></contrib><contrib contrib-type="author"><name><surname>Brauch</surname><given-names>Hiltrud</given-names></name><address><email>hiltrud.brauch@ikp-stuttgart.de</email></address><xref ref-type="aff" rid="Aff26"></xref><xref ref-type="aff" rid="Aff27"></xref><xref ref-type="aff" rid="Aff28"></xref></contrib><contrib contrib-type="author"><name><surname>Southey</surname><given-names>Melissa C.</given-names></name><address><email>msouthey@unimelb.edu.au</email></address><xref ref-type="aff" rid="Aff29"></xref></contrib><contrib contrib-type="author"><name><surname>Hopper</surname><given-names>John L.</given-names></name><address><email>j.hopper@unimelb.edu.au</email></address><xref ref-type="aff" rid="Aff22"></xref></contrib><contrib contrib-type="author"><name><surname>Dörk</surname><given-names>Thilo</given-names></name><address><email>doerk.thilo@mh-hannover.de</email></address><xref ref-type="aff" rid="Aff30"></xref></contrib><contrib contrib-type="author"><name><surname>Bogdanova</surname><given-names>Natalia V.</given-names></name><address><email>bogdanova.natalia@mh-hannover.de</email></address><xref ref-type="aff" rid="Aff31"></xref></contrib><contrib contrib-type="author"><name><surname>Kabisch</surname><given-names>Maria</given-names></name><address><email>m.kabisch@dkfz.de</email></address><xref ref-type="aff" rid="Aff32"></xref></contrib><contrib contrib-type="author"><name><surname>Hamann</surname><given-names>Ute</given-names></name><address><email>u.hamann@dkfz-heidelberg.de</email></address><xref ref-type="aff" rid="Aff32"></xref></contrib><contrib contrib-type="author"><name><surname>Schmutzler</surname><given-names>Rita K.</given-names></name><address><email>rita.schmutzler@uk-koeln.de</email></address><xref ref-type="aff" rid="Aff33"></xref><xref ref-type="aff" rid="Aff34"></xref><xref ref-type="aff" rid="Aff35"></xref></contrib><contrib contrib-type="author"><name><surname>Meindl</surname><given-names>Alfons</given-names></name><address><email>alfons.meindl@lrz.tu-muenchen.de</email></address><xref ref-type="aff" rid="Aff36"></xref></contrib><contrib contrib-type="author"><name><surname>Brenner</surname><given-names>Hermann</given-names></name><address><email>h.brenner@dkfz.de</email></address><xref ref-type="aff" rid="Aff28"></xref><xref ref-type="aff" rid="Aff37"></xref><xref ref-type="aff" rid="Aff38"></xref></contrib><contrib contrib-type="author"><name><surname>Arndt</surname><given-names>Volker</given-names></name><address><email>v.arndt@dkfz.de</email></address><xref ref-type="aff" rid="Aff37"></xref></contrib><contrib contrib-type="author"><name><surname>Winqvist</surname><given-names>Robert</given-names></name><address><email>robert.winqvist@oulu.fi</email></address><xref ref-type="aff" rid="Aff39"></xref><xref ref-type="aff" rid="Aff40"></xref></contrib><contrib contrib-type="author"><name><surname>Pylkäs</surname><given-names>Katri</given-names></name><address><email>katri.pylkas@oulu.fi</email></address><xref ref-type="aff" rid="Aff39"></xref><xref ref-type="aff" rid="Aff40"></xref></contrib><contrib contrib-type="author"><name><surname>Fasching</surname><given-names>Peter A.</given-names></name><address><email>peter.fasching@uk-erlangen.de</email></address><xref ref-type="aff" rid="Aff41"></xref><xref ref-type="aff" rid="Aff42"></xref></contrib><contrib contrib-type="author"><name><surname>Beckmann</surname><given-names>Matthias W.</given-names></name><address><email>Fk-direktion@uk-erlangen.de</email></address><xref ref-type="aff" rid="Aff41"></xref></contrib><contrib contrib-type="author"><name><surname>Lubinski</surname><given-names>Jan</given-names></name><address><email>lubinski@pum.edu.pl</email></address><xref ref-type="aff" rid="Aff43"></xref></contrib><contrib contrib-type="author"><name><surname>Jakubowska</surname><given-names>Anna</given-names></name><address><email>aniaj@pum.edu.pl</email></address><xref ref-type="aff" rid="Aff43"></xref></contrib><contrib contrib-type="author"><name><surname>Mulligan</surname><given-names>Anna Marie</given-names></name><address><email>AnnaMarie.Mulligan@uhn.ca</email></address><xref ref-type="aff" rid="Aff44"></xref><xref ref-type="aff" rid="Aff45"></xref></contrib><contrib contrib-type="author"><name><surname>Andrulis</surname><given-names>Irene L.</given-names></name><address><email>andrulis@lunenfeld.ca</email></address><xref ref-type="aff" rid="Aff46"></xref><xref ref-type="aff" rid="Aff47"></xref></contrib><contrib contrib-type="author"><name><surname>Tollenaar</surname><given-names>Rob A. 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M.</given-names></name><address><email>r.a.e.m.tollenaar@lumc.nl</email></address><xref ref-type="aff" rid="Aff48"></xref></contrib><contrib contrib-type="author"><name><surname>Devilee</surname><given-names>Peter</given-names></name><address><email>p.devilee@lumc.nl</email></address><xref ref-type="aff" rid="Aff49"></xref><xref ref-type="aff" rid="Aff50"></xref></contrib><contrib contrib-type="author"><name><surname>Le Marchand</surname><given-names>Loic</given-names></name><address><email>loic@crch.hawaii.edu</email></address><xref ref-type="aff" rid="Aff51"></xref></contrib><contrib contrib-type="author"><name><surname>Haiman</surname><given-names>Christopher A.</given-names></name><address><email>Christopher.Haiman@med.usc.edu</email></address><xref ref-type="aff" rid="Aff52"></xref></contrib><contrib contrib-type="author"><name><surname>Mannermaa</surname><given-names>Arto</given-names></name><address><email>arto.mannermaa@uef.fi</email></address><xref ref-type="aff" rid="Aff53"></xref><xref ref-type="aff" rid="Aff54"></xref><xref ref-type="aff" rid="Aff55"></xref></contrib><contrib contrib-type="author"><name><surname>Kosma</surname><given-names>Veli-Matti</given-names></name><address><email>veli-matti.kosma@uef.fi</email></address><xref ref-type="aff" rid="Aff53"></xref><xref ref-type="aff" rid="Aff54"></xref><xref ref-type="aff" rid="Aff55"></xref></contrib><contrib contrib-type="author"><name><surname>Radice</surname><given-names>Paolo</given-names></name><address><email>paolo.radice@istitutotumori.mi.it</email></address><xref ref-type="aff" rid="Aff56"></xref></contrib><contrib contrib-type="author"><name><surname>Peterlongo</surname><given-names>Paolo</given-names></name><address><email>paolo.peterlongo@ifom.eu</email></address><xref ref-type="aff" rid="Aff57"></xref></contrib><contrib contrib-type="author"><name><surname>Marme</surname><given-names>Frederik</given-names></name><address><email>frederikmarme@gmail.com</email></address><xref ref-type="aff" rid="Aff58"></xref><xref ref-type="aff" rid="Aff59"></xref></contrib><contrib contrib-type="author"><name><surname>Burwinkel</surname><given-names>Barbara</given-names></name><address><email>Barbara.Burwinkel@med.uni-heidelberg.de</email></address><xref ref-type="aff" rid="Aff59"></xref><xref ref-type="aff" rid="Aff60"></xref></contrib><contrib contrib-type="author"><name><surname>van Deurzen</surname><given-names>Carolien H. 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rid="Aff64"></xref><xref ref-type="aff" rid="Aff65"></xref></contrib><contrib contrib-type="author"><name><surname>Floris</surname><given-names>Giuseppe</given-names></name><address><email>Giuseppe.Floris@uzleuven.be</email></address><xref ref-type="aff" rid="Aff66"></xref></contrib><contrib contrib-type="author"><name><surname>Wesseling</surname><given-names>Jelle</given-names></name><address><email>j.wesseling@nki.nl</email></address><xref ref-type="aff" rid="Aff67"></xref></contrib><contrib contrib-type="author"><name><surname>Flyger</surname><given-names>Henrik</given-names></name><address><email>henrik.flyger@regionh.dk</email></address><xref ref-type="aff" rid="Aff68"></xref></contrib><contrib contrib-type="author"><name><surname>Bojesen</surname><given-names>Stig E.</given-names></name><address><email>stig.egil.bojesen@regionh.dk</email></address><xref ref-type="aff" rid="Aff69"></xref><xref ref-type="aff" rid="Aff70"></xref><xref ref-type="aff" rid="Aff71"></xref></contrib><contrib contrib-type="author"><name><surname>Yao</surname><given-names>Song</given-names></name><address><email>song.yao@roswellpark.org</email></address><xref ref-type="aff" rid="Aff72"></xref></contrib><contrib contrib-type="author"><name><surname>Ambrosone</surname><given-names>Christine B.</given-names></name><address><email>Christine.ambrosone@roswellpark.org</email></address><xref ref-type="aff" rid="Aff73"></xref></contrib><contrib contrib-type="author"><name><surname>Chenevix-Trench</surname><given-names>Georgia</given-names></name><address><email>Georgia.Trench@qimrberghofer.edu.au</email></address><xref ref-type="aff" rid="Aff74"></xref></contrib><contrib contrib-type="author"><name><surname>Truong</surname><given-names>Thérèse</given-names></name><address><email>therese.truong@inserm.fr</email></address><xref ref-type="aff" rid="Aff75"></xref><xref ref-type="aff" rid="Aff76"></xref></contrib><contrib contrib-type="author"><name><surname>Guénel</surname><given-names>Pascal</given-names></name><address><email>pascal.guenel@inserm.fr</email></address><xref ref-type="aff" rid="Aff75"></xref><xref ref-type="aff" rid="Aff76"></xref></contrib><contrib contrib-type="author"><name><surname>Rudolph</surname><given-names>Anja</given-names></name><address><email>a.rudolph@dkfz.de</email></address><xref ref-type="aff" rid="Aff77"></xref></contrib><contrib contrib-type="author"><name><surname>Chang-Claude</surname><given-names>Jenny</given-names></name><address><email>j.chang-claude@dkfz-heidelberg.de</email></address><xref ref-type="aff" rid="Aff77"></xref></contrib><contrib contrib-type="author"><name><surname>Nevanlinna</surname><given-names>Heli</given-names></name><address><email>Heli.Nevanlinna@hus.fi</email></address><xref ref-type="aff" rid="Aff78"></xref></contrib><contrib contrib-type="author"><name><surname>Blomqvist</surname><given-names>Carl</given-names></name><address><email>carl.blomqvist@helsinki.fi</email></address><xref ref-type="aff" rid="Aff79"></xref></contrib><contrib contrib-type="author"><name><surname>Czene</surname><given-names>Kamila</given-names></name><address><email>kamila.czene@ki.se</email></address><xref ref-type="aff" rid="Aff15"></xref></contrib><contrib contrib-type="author"><name><surname>Brand</surname><given-names>Judith S.</given-names></name><address><email>judith.brand@ki.se</email></address><xref ref-type="aff" rid="Aff15"></xref></contrib><contrib contrib-type="author"><name><surname>Olson</surname><given-names>Janet E.</given-names></name><address><email>olsonj@mayo.edu</email></address><xref ref-type="aff" rid="Aff80"></xref></contrib><contrib contrib-type="author"><name><surname>Couch</surname><given-names>Fergus J.</given-names></name><address><email>couch.fergus@mayo.edu</email></address><xref ref-type="aff" rid="Aff81"></xref></contrib><contrib contrib-type="author"><name><surname>Dunning</surname><given-names>Alison M.</given-names></name><address><email>amd24@medschl.cam.ac.uk</email></address><xref ref-type="aff" rid="Aff82"></xref></contrib><contrib contrib-type="author"><name><surname>Hall</surname><given-names>Per</given-names></name><address><email>Per.Hall@ki.se</email></address><xref ref-type="aff" rid="Aff15"></xref></contrib><contrib contrib-type="author"><name><surname>Easton</surname><given-names>Douglas F.</given-names></name><address><email>dfe20@medschl.cam.ac.uk</email></address><xref ref-type="aff" rid="Aff11"></xref><xref ref-type="aff" rid="Aff82"></xref></contrib><contrib contrib-type="author"><name><surname>Pharoah</surname><given-names>Paul D. P.</given-names></name><address><email>pp10001@medschl.cam.ac.uk</email></address><xref ref-type="aff" rid="Aff11"></xref><xref ref-type="aff" rid="Aff82"></xref></contrib><contrib contrib-type="author"><name><surname>Pinder</surname><given-names>Sarah E.</given-names></name><address><email>sarah.pinder@kcl.ac.uk</email></address><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Schmidt</surname><given-names>Marjanka K</given-names></name><address><email>mk.schmidt@nki.nl</email></address><xref ref-type="aff" rid="Aff67"></xref></contrib><contrib contrib-type="author"><name><surname>Tomlinson</surname><given-names>Ian</given-names></name><address><email>iant@well.ox.ac.uk</email></address><xref ref-type="aff" rid="Aff83"></xref></contrib><contrib contrib-type="author"><name><surname>Roylance</surname><given-names>Rebecca</given-names></name><address><email>r.roylance@qmul.ac.uk</email></address><xref ref-type="aff" rid="Aff4"></xref></contrib><contrib contrib-type="author"><name><surname>García-Closas</surname><given-names>Montserrat</given-names></name><address><email>montserrat.garcia-closas@nih.gov</email></address><xref ref-type="aff" rid="Aff3"></xref><xref ref-type="aff" rid="Aff16"></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Sawyer</surname><given-names>Elinor J.</given-names></name><address><phone>+44 (0) 20 7188 7843</phone><email>elinor.sawyer@kcl.ac.uk</email></address><xref ref-type="aff" rid="Aff1"></xref></contrib><aff id="Aff1"><label></label>Research Oncology, Guy’s Hospital, King’s College London, London, UK</aff><aff id="Aff2"><label></label>Medical and Molecular Genetics, Guy’s Hospital, King’s College London, London, UK</aff><aff id="Aff3"><label></label>Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK</aff><aff id="Aff4"><label></label>Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK</aff><aff id="Aff5"><label></label>Biomedical Research Centre, King’s College London, Guy’s Hospital, London, UK</aff><aff id="Aff6"><label></label>The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK</aff><aff id="Aff7"><label></label>Sheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield, UK</aff><aff id="Aff8"><label></label>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK</aff><aff id="Aff9"><label></label>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</aff><aff id="Aff10"><label></label>Division of Breast Cancer Research, The Institute of Cancer Research, London, UK</aff><aff id="Aff11"><label></label>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</aff><aff id="Aff12"><label></label>Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain</aff><aff id="Aff13"><label></label>Centro de Investigación en Red de Enfermedades Raras, Valencia, Spain</aff><aff id="Aff14"><label></label>Centre d’innovation Génome Québec et Université McGill, Montréal, Canada</aff><aff id="Aff15"><label></label>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</aff><aff id="Aff16"><label></label>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD USA</aff><aff id="Aff17"><label></label>Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway</aff><aff id="Aff18"><label></label>K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway</aff><aff id="Aff19"><label></label>Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo, Norway</aff><aff id="Aff20"><label></label>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Canada</aff><aff id="Aff21"><label></label>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</aff><aff id="Aff22"><label></label>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne, VIC Australia</aff><aff id="Aff23"><label></label>Department of Oncology - Pathology, Karolinska Institutet, Stockholm, Sweden</aff><aff id="Aff24"><label></label>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden</aff><aff id="Aff25"><label></label>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum, Germany</aff><aff id="Aff26"><label></label>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany</aff><aff id="Aff27"><label></label>University of Tübingen, Tübingen, Germany</aff><aff id="Aff28"><label></label>German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="Aff29"><label></label>Department of Pathology, The University of Melbourne, Melbourne, Australia</aff><aff id="Aff30"><label></label>Gynaecology Research Unit, Hannover Medical School, Hannover, Germany</aff><aff id="Aff31"><label></label>Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</aff><aff id="Aff32"><label></label>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="Aff33"><label></label>Center for Familial Breast and Ovarian Cancer, Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany</aff><aff id="Aff34"><label></label>Center for Integrated Oncology (CIO), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany</aff><aff id="Aff35"><label></label>Center for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany</aff><aff id="Aff36"><label></label>Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany</aff><aff id="Aff37"><label></label>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="Aff38"><label></label>Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="Aff39"><label></label>Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland</aff><aff id="Aff40"><label></label>Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland</aff><aff id="Aff41"><label></label>Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany</aff><aff id="Aff42"><label></label>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA USA</aff><aff id="Aff43"><label></label>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</aff><aff id="Aff44"><label></label>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada</aff><aff id="Aff45"><label></label>Laboratory Medicine Program, University Health Network, Toronto, Canada</aff><aff id="Aff46"><label></label>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</aff><aff id="Aff47"><label></label>Department of Molecular Genetics, University of Toronto, Toronto, Canada</aff><aff id="Aff48"><label></label>Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands</aff><aff id="Aff49"><label></label>Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands</aff><aff id="Aff50"><label></label>Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands</aff><aff id="Aff51"><label></label>University of Hawaii Cancer Center, Honolulu, HI USA</aff><aff id="Aff52"><label></label>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA USA</aff><aff id="Aff53"><label></label>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</aff><aff id="Aff54"><label></label>Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</aff><aff id="Aff55"><label></label>Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland</aff><aff id="Aff56"><label></label>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan, Italy</aff><aff id="Aff57"><label></label>IFOM, Fondazione Istituto FIRC (Italian Foundation of Cancer Research) di Oncologia Molecolare, Milan, Italy</aff><aff id="Aff58"><label></label>National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</aff><aff id="Aff59"><label></label>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</aff><aff id="Aff60"><label></label>Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="Aff61"><label></label>Department of Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands</aff><aff id="Aff62"><label></label>Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands</aff><aff id="Aff63"><label></label>School of Medicine, National University of Ireland, Galway, Ireland</aff><aff id="Aff64"><label></label>Vesalius Research Center, VIB, Leuven, Belgium</aff><aff id="Aff65"><label></label>Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium</aff><aff id="Aff66"><label></label>University Hospital Gashuisberg, Leuven, Belgium</aff><aff id="Aff67"><label></label>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</aff><aff id="Aff68"><label></label>Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</aff><aff id="Aff69"><label></label>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</aff><aff id="Aff70"><label></label>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</aff><aff id="Aff71"><label></label>Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</aff><aff id="Aff72"><label></label>Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY USA</aff><aff id="Aff73"><label></label>Roswell Park Cancer Institute, Buffalo, NY USA</aff><aff id="Aff74"><label></label>Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia</aff><aff id="Aff75"><label></label>Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France</aff><aff id="Aff76"><label></label>University Paris-Sud, Villejuif, France</aff><aff id="Aff77"><label></label>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="Aff78"><label></label>Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland</aff><aff id="Aff79"><label></label>Department of Oncology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland</aff><aff id="Aff80"><label></label>Department of Health Sciences Research, Mayo Clinic, Rochester, MN USA</aff><aff id="Aff81"><label></label>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN USA</aff><aff id="Aff82"><label></label>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</aff><aff id="Aff83"><label></label>Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK</aff></contrib-group><pub-date pub-type="epub"><day>17</day><month>2</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>17</day><month>2</month><year>2016</year></pub-date><pub-date pub-type="ppub"><year>2016</year></pub-date><volume>18</volume><elocation-id>22</elocation-id><history><date date-type="received"><day>1</day><month>9</month><year>2015</year></date><date date-type="accepted"><day>6</day><month>1</month><year>2016</year></date></history><permissions><copyright-statement>© Petridis et al. 2016</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold>This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>) applies to the data made available in this article, unless otherwise stated.</license-p></license></permissions><abstract id="Abs1"><sec><title>Background</title><p>Ductal carcinoma <italic>in situ</italic> (DCIS) is a non-invasive form of breast cancer. It is often associated with invasive ductal carcinoma (IDC), and is considered to be a non-obligate precursor of IDC. It is not clear to what extent these two forms of cancer share low-risk susceptibility loci, or whether there are differences in the strength of association for shared loci.</p></sec><sec><title>Methods</title><p>To identify genetic polymorphisms that predispose to DCIS, we pooled data from 38 studies comprising 5,067 cases of DCIS, 24,584 cases of IDC and 37,467 controls, all genotyped using the iCOGS chip.</p></sec><sec><title>Results</title><p>Most (67 %) of the 76 known breast cancer predisposition loci showed an association with DCIS in the same direction as previously reported for invasive breast cancer. Case-only analysis showed no evidence for differences between associations for IDC and DCIS after considering multiple testing.</p><p>Analysis by estrogen receptor (ER) status confirmed that loci associated with ER positive IDC were also associated with ER positive DCIS. Analysis of DCIS by grade suggested that two independent SNPs at 11q13.3 near <italic>CCND1</italic> were specific to low/intermediate grade DCIS (rs75915166, rs554219). These associations with grade remained after adjusting for ER status and were also found in IDC.</p><p>We found no novel DCIS-specific loci at a genome wide significance level of <italic>P</italic> < 5.0x10<sup>-8</sup>.</p></sec><sec><title>Conclusion</title><p>In conclusion, this study provides the strongest evidence to date of a shared genetic susceptibility for IDC and DCIS. Studies with larger numbers of DCIS are needed to determine if IDC or DCIS specific loci exist.</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/s13058-016-0675-7) contains supplementary material, which is available to authorized users.</p></sec></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Ductal carcinoma in situ</kwd><kwd>Association study</kwd><kwd>Genetic predisposition</kwd><kwd>Common variants</kwd></kwd-group><funding-group><award-group><funding-source><institution-wrap><institution-id institution-id-type="FundRef">http://dx.doi.org/10.13039/501100000301</institution-id><institution>Breast Cancer Campaign (GB)</institution></institution-wrap></funding-source><award-id>2011NovPR49</award-id><principal-award-recipient><name><surname>Sawyer</surname><given-names>Elinor J.</given-names></name></principal-award-recipient></award-group><award-group><funding-source><institution-wrap><institution-id institution-id-type="FundRef">http://dx.doi.org/10.13039/501100000289</institution-id><institution>Cancer Research UK (GB)</institution></institution-wrap></funding-source><award-id>CRUK/08/046</award-id><principal-award-recipient><name><surname>Roylance</surname><given-names>Rebecca</given-names></name></principal-award-recipient></award-group><award-group><funding-source><institution>the European Community's Seventh Framework Programme</institution></funding-source><award-id>HEALTH-F2-2009-223175</award-id><principal-award-recipient><name><surname>Hall</surname><given-names>Per</given-names></name></principal-award-recipient></award-group><award-group><funding-source><institution-wrap><institution-id institution-id-type="FundRef">http://dx.doi.org/10.13039/501100000289</institution-id><institution>Cancer Research UK (GB)</institution></institution-wrap></funding-source><award-id>C1287/A10118</award-id><principal-award-recipient><name><surname>Easton</surname><given-names>Douglas F.</given-names></name></principal-award-recipient></award-group><award-group><funding-source><institution-wrap><institution-id institution-id-type="FundRef">http://dx.doi.org/10.13039/501100000289</institution-id><institution>Cancer Research UK (GB)</institution></institution-wrap></funding-source><award-id>C1287/A12014</award-id><principal-award-recipient><name><surname>Easton</surname><given-names>Douglas F.</given-names></name></principal-award-recipient></award-group></funding-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2016</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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