Genetic predisposition to ductal carcinoma in situ of the breast
Identifieur interne : 000B41 ( Pmc/Corpus ); précédent : 000B40; suivant : 000B42Genetic predisposition to ductal carcinoma in situ of the breast
Auteurs : Christos Petridis ; Mark N. Brook ; Vandna Shah ; Kelly Kohut ; Patricia Gorman ; Michele Caneppele ; Dina Levi ; Efterpi Papouli ; Nick Orr ; Angela Cox ; Simon S. Cross ; Isabel Dos-Santos-Silva ; Julian Peto ; Anthony Swerdlow ; Minouk J. Schoemaker ; Manjeet K. Bolla ; Qin Wang ; Joe Dennis ; Kyriaki Michailidou ; Javier Benitez ; Anna González-Neira ; Daniel C. Tessier ; Daniel Vincent ; Jingmei Li ; Jonine Figueroa ; Vessela Kristensen ; Anne-Lise Borresen-Dale ; Penny Soucy ; Jacques Simard ; Roger L. Milne ; Graham G. Giles ; Sara Margolin ; Annika Lindblom ; Thomas Brüning ; Hiltrud Brauch ; Melissa C. Southey ; John L. Hopper ; Thilo Dörk ; Natalia V. Bogdanova ; Maria Kabisch ; Ute Hamann ; Rita K. Schmutzler ; Alfons Meindl ; Hermann Brenner ; Volker Arndt ; Robert Winqvist ; Katri Pylk S ; Peter A. Fasching ; Matthias W. Beckmann ; Jan Lubinski ; Anna Jakubowska ; Anna Marie Mulligan ; Irene L. Andrulis ; Rob A. E. M. Tollenaar ; Peter Devilee ; Loic Le Marchand ; Christopher A. Haiman ; Arto Mannermaa ; Veli-Matti Kosma ; Paolo Radice ; Paolo Peterlongo ; Frederik Marme ; Barbara Burwinkel ; Carolien H. M. Van Deurzen ; Antoinette Hollestelle ; Nicola Miller ; Michael J. Kerin ; Diether Lambrechts ; Giuseppe Floris ; Jelle Wesseling ; Henrik Flyger ; Stig E. Bojesen ; Song Yao ; Christine B. Ambrosone ; Georgia Chenevix-Trench ; Thérèse Truong ; Pascal Guénel ; Anja Rudolph ; Jenny Chang-Claude ; Heli Nevanlinna ; Carl Blomqvist ; Kamila Czene ; Judith S. Brand ; Janet E. Olson ; Fergus J. Couch ; Alison M. Dunning ; Per Hall ; Douglas F. Easton ; Paul D. P. Pharoah ; Sarah E. Pinder ; Marjanka K. Schmidt ; Ian Tomlinson ; Rebecca Roylance ; Montserrat García-Closas ; Elinor J. SawyerSource :
- Breast Cancer Research : BCR [ 1465-5411 ] ; 2016.
Abstract
Ductal carcinoma
To identify genetic polymorphisms that predispose to DCIS, we pooled data from 38 studies comprising 5,067 cases of DCIS, 24,584 cases of IDC and 37,467 controls, all genotyped using the iCOGS chip.
Most (67 %) of the 76 known breast cancer predisposition loci showed an association with DCIS in the same direction as previously reported for invasive breast cancer. Case-only analysis showed no evidence for differences between associations for IDC and DCIS after considering multiple testing.
Analysis by estrogen receptor (ER) status confirmed that loci associated with ER positive IDC were also associated with ER positive DCIS. Analysis of DCIS by grade suggested that two independent SNPs at 11q13.3 near
We found no novel DCIS-specific loci at a genome wide significance level of
In conclusion, this study provides the strongest evidence to date of a shared genetic susceptibility for IDC and DCIS. Studies with larger numbers of DCIS are needed to determine if IDC or DCIS specific loci exist.
The online version of this article (doi:10.1186/s13058-016-0675-7) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s13058-016-0675-7
PubMed: 26884359
PubMed Central: 4756509
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PMC:4756509Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genetic predisposition to ductal carcinoma <italic>in situ</italic> of the breast</title><author><name sortKey="Petridis, Christos" sort="Petridis, Christos" uniqKey="Petridis C" first="Christos" last="Petridis">Christos Petridis</name><affiliation><nlm:aff id="Aff1">Research Oncology, Guy’s Hospital, King’s College London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="Aff2">Medical and Molecular Genetics, Guy’s Hospital, King’s College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Brook, Mark N" sort="Brook, Mark N" uniqKey="Brook M" first="Mark N." last="Brook">Mark N. Brook</name><affiliation><nlm:aff id="Aff3">Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Shah, Vandna" sort="Shah, Vandna" uniqKey="Shah V" first="Vandna" last="Shah">Vandna Shah</name><affiliation><nlm:aff id="Aff1">Research Oncology, Guy’s Hospital, King’s College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kohut, Kelly" sort="Kohut, Kelly" uniqKey="Kohut K" first="Kelly" last="Kohut">Kelly Kohut</name><affiliation><nlm:aff id="Aff4">Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Gorman, Patricia" sort="Gorman, Patricia" uniqKey="Gorman P" first="Patricia" last="Gorman">Patricia Gorman</name><affiliation><nlm:aff id="Aff4">Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Caneppele, Michele" sort="Caneppele, Michele" uniqKey="Caneppele M" first="Michele" last="Caneppele">Michele Caneppele</name><affiliation><nlm:aff id="Aff4">Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Levi, Dina" sort="Levi, Dina" uniqKey="Levi D" first="Dina" last="Levi">Dina Levi</name><affiliation><nlm:aff id="Aff1">Research Oncology, Guy’s Hospital, King’s College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Papouli, Efterpi" sort="Papouli, Efterpi" uniqKey="Papouli E" first="Efterpi" last="Papouli">Efterpi Papouli</name><affiliation><nlm:aff id="Aff5">Biomedical Research Centre, King’s College London, Guy’s Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name><affiliation><nlm:aff id="Aff6">The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="Aff7">Sheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name><affiliation><nlm:aff id="Aff8">Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name><affiliation><nlm:aff id="Aff9">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</nlm:aff></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:aff id="Aff9">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</nlm:aff></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation><nlm:aff id="Aff3">Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="Aff10">Division of Breast Cancer Research, The Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Schoemaker, Minouk J" sort="Schoemaker, Minouk J" uniqKey="Schoemaker M" first="Minouk J." last="Schoemaker">Minouk J. Schoemaker</name><affiliation><nlm:aff id="Aff3">Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name><affiliation><nlm:aff id="Aff11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation><nlm:aff id="Aff11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation><nlm:aff id="Aff11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation><nlm:aff id="Aff11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation><nlm:aff id="Aff12">Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="Aff13">Centro de Investigación en Red de Enfermedades Raras, Valencia, Spain</nlm:aff></affiliation></author><author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name><affiliation><nlm:aff id="Aff12">Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Tessier, Daniel C" sort="Tessier, Daniel C" uniqKey="Tessier D" first="Daniel C." last="Tessier">Daniel C. Tessier</name><affiliation><nlm:aff id="Aff14">Centre d’innovation Génome Québec et Université McGill, Montréal, Canada</nlm:aff></affiliation></author><author><name sortKey="Vincent, Daniel" sort="Vincent, Daniel" uniqKey="Vincent D" first="Daniel" last="Vincent">Daniel Vincent</name><affiliation><nlm:aff id="Aff14">Centre d’innovation Génome Québec et Université McGill, Montréal, Canada</nlm:aff></affiliation></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name><affiliation><nlm:aff id="Aff15">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name><affiliation><nlm:aff id="Aff16">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD USA</nlm:aff></affiliation></author><author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name><affiliation><nlm:aff id="Aff17">Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="Aff18">K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="Aff19">Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Borresen Dale, Anne Lise" sort="Borresen Dale, Anne Lise" uniqKey="Borresen Dale A" first="Anne-Lise" last="Borresen-Dale">Anne-Lise Borresen-Dale</name><affiliation><nlm:aff id="Aff17">Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="Aff18">K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Soucy, Penny" sort="Soucy, Penny" uniqKey="Soucy P" first="Penny" last="Soucy">Penny Soucy</name><affiliation><nlm:aff id="Aff20">Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Canada</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="Aff20">Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Canada</nlm:aff></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation><nlm:aff id="Aff21">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff22">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne, VIC Australia</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="Aff21">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff22">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne, VIC Australia</nlm:aff></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation><nlm:aff id="Aff23">Department of Oncology - Pathology, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation><nlm:aff id="Aff24">Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name><affiliation><nlm:aff id="Aff25">Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum, Germany</nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation><nlm:aff id="Aff26">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff27">University of Tübingen, Tübingen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff28">German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="Aff29">Department of Pathology, The University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="Aff22">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne, VIC Australia</nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation><nlm:aff id="Aff30">Gynaecology Research Unit, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V." last="Bogdanova">Natalia V. Bogdanova</name><affiliation><nlm:aff id="Aff31">Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Kabisch, Maria" sort="Kabisch, Maria" uniqKey="Kabisch M" first="Maria" last="Kabisch">Maria Kabisch</name><affiliation><nlm:aff id="Aff32">Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="Aff32">Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="Aff33">Center for Familial Breast and Ovarian Cancer, Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff34">Center for Integrated Oncology (CIO), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff35">Center for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="Aff36">Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="Aff28">German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff37">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff38">Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="Aff37">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation><nlm:aff id="Aff39">Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="Aff40">Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation><nlm:aff id="Aff39">Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="Aff40">Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="Aff41">Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff42">David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA USA</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="Aff41">Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="Aff43">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="Aff43">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Mulligan, Anna Marie" sort="Mulligan, Anna Marie" uniqKey="Mulligan A" first="Anna Marie" last="Mulligan">Anna Marie Mulligan</name><affiliation><nlm:aff id="Aff44">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="Aff45">Laboratory Medicine Program, University Health Network, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="Aff46">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="Aff47">Department of Molecular Genetics, University of Toronto, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Tollenaar, Rob A E M" sort="Tollenaar, Rob A E M" uniqKey="Tollenaar R" first="Rob A. E. M." last="Tollenaar">Rob A. E. M. Tollenaar</name><affiliation><nlm:aff id="Aff48">Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation><nlm:aff id="Aff49">Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="Aff50">Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="Aff51">University of Hawaii Cancer Center, Honolulu, HI USA</nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff id="Aff52">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA USA</nlm:aff></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation><nlm:aff id="Aff53">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="Aff54">Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="Aff55">Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation><nlm:aff id="Aff53">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="Aff54">Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="Aff55">Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff id="Aff56">Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="Aff57">IFOM, Fondazione Istituto FIRC (Italian Foundation of Cancer Research) di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name><affiliation><nlm:aff id="Aff58">National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff59">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation><nlm:aff id="Aff59">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff60">Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Van Deurzen, Carolien H M" sort="Van Deurzen, Carolien H M" uniqKey="Van Deurzen C" first="Carolien H. M." last="Van Deurzen">Carolien H. M. Van Deurzen</name><affiliation><nlm:aff id="Aff61">Department of Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name><affiliation><nlm:aff id="Aff62">Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name><affiliation><nlm:aff id="Aff63">School of Medicine, National University of Ireland, Galway, Ireland</nlm:aff></affiliation></author><author><name sortKey="Kerin, Michael J" sort="Kerin, Michael J" uniqKey="Kerin M" first="Michael J." last="Kerin">Michael J. Kerin</name><affiliation><nlm:aff id="Aff63">School of Medicine, National University of Ireland, Galway, Ireland</nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="Aff64">Vesalius Research Center, VIB, Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="Aff65">Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Floris, Giuseppe" sort="Floris, Giuseppe" uniqKey="Floris G" first="Giuseppe" last="Floris">Giuseppe Floris</name><affiliation><nlm:aff id="Aff66">University Hospital Gashuisberg, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Wesseling, Jelle" sort="Wesseling, Jelle" uniqKey="Wesseling J" first="Jelle" last="Wesseling">Jelle Wesseling</name><affiliation><nlm:aff id="Aff67">Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation><nlm:aff id="Aff68">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="Aff69">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="Aff70">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="Aff71">Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Yao, Song" sort="Yao, Song" uniqKey="Yao S" first="Song" last="Yao">Song Yao</name><affiliation><nlm:aff id="Aff72">Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY USA</nlm:aff></affiliation></author><author><name sortKey="Ambrosone, Christine B" sort="Ambrosone, Christine B" uniqKey="Ambrosone C" first="Christine B." last="Ambrosone">Christine B. Ambrosone</name><affiliation><nlm:aff id="Aff73">Roswell Park Cancer Institute, Buffalo, NY USA</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="Aff74">Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation><nlm:aff id="Aff75">Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="Aff76">University Paris-Sud, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation><nlm:aff id="Aff75">Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="Aff76">University Paris-Sud, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="Aff77">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="Aff77">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="Aff78">Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation><nlm:aff id="Aff79">Department of Oncology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="Aff15">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Brand, Judith S" sort="Brand, Judith S" uniqKey="Brand J" first="Judith S." last="Brand">Judith S. Brand</name><affiliation><nlm:aff id="Aff15">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name><affiliation><nlm:aff id="Aff80">Department of Health Sciences Research, Mayo Clinic, Rochester, MN USA</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="Aff81">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN USA</nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="Aff82">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="Aff15">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="Aff11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="Aff82">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name><affiliation><nlm:aff id="Aff11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="Aff82">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Pinder, Sarah E" sort="Pinder, Sarah E" uniqKey="Pinder S" first="Sarah E." last="Pinder">Sarah E. Pinder</name><affiliation><nlm:aff id="Aff1">Research Oncology, Guy’s Hospital, King’s College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K" last="Schmidt">Marjanka K. Schmidt</name><affiliation><nlm:aff id="Aff67">Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation><nlm:aff id="Aff83">Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Roylance, Rebecca" sort="Roylance, Rebecca" uniqKey="Roylance R" first="Rebecca" last="Roylance">Rebecca Roylance</name><affiliation><nlm:aff id="Aff4">Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name><affiliation><nlm:aff id="Aff3">Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="Aff16">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD USA</nlm:aff></affiliation></author><author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J." last="Sawyer">Elinor J. 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Brook</name><affiliation><nlm:aff id="Aff3">Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Shah, Vandna" sort="Shah, Vandna" uniqKey="Shah V" first="Vandna" last="Shah">Vandna Shah</name><affiliation><nlm:aff id="Aff1">Research Oncology, Guy’s Hospital, King’s College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kohut, Kelly" sort="Kohut, Kelly" uniqKey="Kohut K" first="Kelly" last="Kohut">Kelly Kohut</name><affiliation><nlm:aff id="Aff4">Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Gorman, Patricia" sort="Gorman, Patricia" uniqKey="Gorman P" first="Patricia" last="Gorman">Patricia Gorman</name><affiliation><nlm:aff id="Aff4">Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Caneppele, Michele" sort="Caneppele, Michele" uniqKey="Caneppele M" first="Michele" last="Caneppele">Michele Caneppele</name><affiliation><nlm:aff id="Aff4">Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Levi, Dina" sort="Levi, Dina" uniqKey="Levi D" first="Dina" last="Levi">Dina Levi</name><affiliation><nlm:aff id="Aff1">Research Oncology, Guy’s Hospital, King’s College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Papouli, Efterpi" sort="Papouli, Efterpi" uniqKey="Papouli E" first="Efterpi" last="Papouli">Efterpi Papouli</name><affiliation><nlm:aff id="Aff5">Biomedical Research Centre, King’s College London, Guy’s Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name><affiliation><nlm:aff id="Aff6">The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="Aff7">Sheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name><affiliation><nlm:aff id="Aff8">Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name><affiliation><nlm:aff id="Aff9">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</nlm:aff></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:aff id="Aff9">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</nlm:aff></affiliation></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><affiliation><nlm:aff id="Aff3">Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="Aff10">Division of Breast Cancer Research, The Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Schoemaker, Minouk J" sort="Schoemaker, Minouk J" uniqKey="Schoemaker M" first="Minouk J." last="Schoemaker">Minouk J. Schoemaker</name><affiliation><nlm:aff id="Aff3">Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name><affiliation><nlm:aff id="Aff11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation><nlm:aff id="Aff11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><affiliation><nlm:aff id="Aff11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation><nlm:aff id="Aff11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation><nlm:aff id="Aff12">Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="Aff13">Centro de Investigación en Red de Enfermedades Raras, Valencia, Spain</nlm:aff></affiliation></author><author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name><affiliation><nlm:aff id="Aff12">Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Tessier, Daniel C" sort="Tessier, Daniel C" uniqKey="Tessier D" first="Daniel C." last="Tessier">Daniel C. Tessier</name><affiliation><nlm:aff id="Aff14">Centre d’innovation Génome Québec et Université McGill, Montréal, Canada</nlm:aff></affiliation></author><author><name sortKey="Vincent, Daniel" sort="Vincent, Daniel" uniqKey="Vincent D" first="Daniel" last="Vincent">Daniel Vincent</name><affiliation><nlm:aff id="Aff14">Centre d’innovation Génome Québec et Université McGill, Montréal, Canada</nlm:aff></affiliation></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name><affiliation><nlm:aff id="Aff15">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name><affiliation><nlm:aff id="Aff16">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD USA</nlm:aff></affiliation></author><author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name><affiliation><nlm:aff id="Aff17">Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="Aff18">K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="Aff19">Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Borresen Dale, Anne Lise" sort="Borresen Dale, Anne Lise" uniqKey="Borresen Dale A" first="Anne-Lise" last="Borresen-Dale">Anne-Lise Borresen-Dale</name><affiliation><nlm:aff id="Aff17">Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="Aff18">K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Soucy, Penny" sort="Soucy, Penny" uniqKey="Soucy P" first="Penny" last="Soucy">Penny Soucy</name><affiliation><nlm:aff id="Aff20">Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Canada</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="Aff20">Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Canada</nlm:aff></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation><nlm:aff id="Aff21">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff22">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne, VIC Australia</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="Aff21">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff22">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne, VIC Australia</nlm:aff></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation><nlm:aff id="Aff23">Department of Oncology - Pathology, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation><nlm:aff id="Aff24">Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name><affiliation><nlm:aff id="Aff25">Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum, Germany</nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation><nlm:aff id="Aff26">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff27">University of Tübingen, Tübingen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff28">German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="Aff29">Department of Pathology, The University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="Aff22">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne, VIC Australia</nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation><nlm:aff id="Aff30">Gynaecology Research Unit, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V." last="Bogdanova">Natalia V. Bogdanova</name><affiliation><nlm:aff id="Aff31">Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Kabisch, Maria" sort="Kabisch, Maria" uniqKey="Kabisch M" first="Maria" last="Kabisch">Maria Kabisch</name><affiliation><nlm:aff id="Aff32">Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="Aff32">Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="Aff33">Center for Familial Breast and Ovarian Cancer, Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff34">Center for Integrated Oncology (CIO), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff35">Center for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="Aff36">Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="Aff28">German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff37">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff38">Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="Aff37">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation><nlm:aff id="Aff39">Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="Aff40">Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation><nlm:aff id="Aff39">Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="Aff40">Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="Aff41">Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff42">David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA USA</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="Aff41">Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="Aff43">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="Aff43">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Mulligan, Anna Marie" sort="Mulligan, Anna Marie" uniqKey="Mulligan A" first="Anna Marie" last="Mulligan">Anna Marie Mulligan</name><affiliation><nlm:aff id="Aff44">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="Aff45">Laboratory Medicine Program, University Health Network, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="Aff46">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="Aff47">Department of Molecular Genetics, University of Toronto, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Tollenaar, Rob A E M" sort="Tollenaar, Rob A E M" uniqKey="Tollenaar R" first="Rob A. E. M." last="Tollenaar">Rob A. E. M. Tollenaar</name><affiliation><nlm:aff id="Aff48">Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation><nlm:aff id="Aff49">Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="Aff50">Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="Aff51">University of Hawaii Cancer Center, Honolulu, HI USA</nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff id="Aff52">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA USA</nlm:aff></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation><nlm:aff id="Aff53">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="Aff54">Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="Aff55">Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation><nlm:aff id="Aff53">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="Aff54">Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="Aff55">Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff id="Aff56">Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="Aff57">IFOM, Fondazione Istituto FIRC (Italian Foundation of Cancer Research) di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name><affiliation><nlm:aff id="Aff58">National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff59">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation><nlm:aff id="Aff59">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff60">Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Van Deurzen, Carolien H M" sort="Van Deurzen, Carolien H M" uniqKey="Van Deurzen C" first="Carolien H. M." last="Van Deurzen">Carolien H. M. Van Deurzen</name><affiliation><nlm:aff id="Aff61">Department of Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name><affiliation><nlm:aff id="Aff62">Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name><affiliation><nlm:aff id="Aff63">School of Medicine, National University of Ireland, Galway, Ireland</nlm:aff></affiliation></author><author><name sortKey="Kerin, Michael J" sort="Kerin, Michael J" uniqKey="Kerin M" first="Michael J." last="Kerin">Michael J. Kerin</name><affiliation><nlm:aff id="Aff63">School of Medicine, National University of Ireland, Galway, Ireland</nlm:aff></affiliation></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><affiliation><nlm:aff id="Aff64">Vesalius Research Center, VIB, Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="Aff65">Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Floris, Giuseppe" sort="Floris, Giuseppe" uniqKey="Floris G" first="Giuseppe" last="Floris">Giuseppe Floris</name><affiliation><nlm:aff id="Aff66">University Hospital Gashuisberg, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Wesseling, Jelle" sort="Wesseling, Jelle" uniqKey="Wesseling J" first="Jelle" last="Wesseling">Jelle Wesseling</name><affiliation><nlm:aff id="Aff67">Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation><nlm:aff id="Aff68">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="Aff69">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="Aff70">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="Aff71">Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Yao, Song" sort="Yao, Song" uniqKey="Yao S" first="Song" last="Yao">Song Yao</name><affiliation><nlm:aff id="Aff72">Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY USA</nlm:aff></affiliation></author><author><name sortKey="Ambrosone, Christine B" sort="Ambrosone, Christine B" uniqKey="Ambrosone C" first="Christine B." last="Ambrosone">Christine B. Ambrosone</name><affiliation><nlm:aff id="Aff73">Roswell Park Cancer Institute, Buffalo, NY USA</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="Aff74">Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation><nlm:aff id="Aff75">Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="Aff76">University Paris-Sud, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation><nlm:aff id="Aff75">Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="Aff76">University Paris-Sud, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="Aff77">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="Aff77">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="Aff78">Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation><nlm:aff id="Aff79">Department of Oncology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="Aff15">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Brand, Judith S" sort="Brand, Judith S" uniqKey="Brand J" first="Judith S." last="Brand">Judith S. Brand</name><affiliation><nlm:aff id="Aff15">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name><affiliation><nlm:aff id="Aff80">Department of Health Sciences Research, Mayo Clinic, Rochester, MN USA</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="Aff81">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN USA</nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="Aff82">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="Aff15">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="Aff11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="Aff82">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name><affiliation><nlm:aff id="Aff11">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="Aff82">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Pinder, Sarah E" sort="Pinder, Sarah E" uniqKey="Pinder S" first="Sarah E." last="Pinder">Sarah E. Pinder</name><affiliation><nlm:aff id="Aff1">Research Oncology, Guy’s Hospital, King’s College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K" last="Schmidt">Marjanka K. Schmidt</name><affiliation><nlm:aff id="Aff67">Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation><nlm:aff id="Aff83">Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Roylance, Rebecca" sort="Roylance, Rebecca" uniqKey="Roylance R" first="Rebecca" last="Roylance">Rebecca Roylance</name><affiliation><nlm:aff id="Aff4">Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name><affiliation><nlm:aff id="Aff3">Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="Aff16">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD USA</nlm:aff></affiliation></author><author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J." last="Sawyer">Elinor J. Sawyer</name><affiliation><nlm:aff id="Aff1">Research Oncology, Guy’s Hospital, King’s College London, London, UK</nlm:aff></affiliation></author></analytic><series><title level="j">Breast Cancer Research : BCR</title><idno type="ISSN">1465-5411</idno><idno type="eISSN">1465-542X</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Ductal carcinoma <italic>in situ</italic> (DCIS) is a non-invasive form of breast cancer. It is often associated with invasive ductal carcinoma (IDC), and is considered to be a non-obligate precursor of IDC. It is not clear to what extent these two forms of cancer share low-risk susceptibility loci, or whether there are differences in the strength of association for shared loci.</p></sec><sec><title>Methods</title><p>To identify genetic polymorphisms that predispose to DCIS, we pooled data from 38 studies comprising 5,067 cases of DCIS, 24,584 cases of IDC and 37,467 controls, all genotyped using the iCOGS chip.</p></sec><sec><title>Results</title><p>Most (67 %) of the 76 known breast cancer predisposition loci showed an association with DCIS in the same direction as previously reported for invasive breast cancer. Case-only analysis showed no evidence for differences between associations for IDC and DCIS after considering multiple testing.</p><p>Analysis by estrogen receptor (ER) status confirmed that loci associated with ER positive IDC were also associated with ER positive DCIS. Analysis of DCIS by grade suggested that two independent SNPs at 11q13.3 near <italic>CCND1</italic> were specific to low/intermediate grade DCIS (rs75915166, rs554219). These associations with grade remained after adjusting for ER status and were also found in IDC.</p><p>We found no novel DCIS-specific loci at a genome wide significance level of <italic>P</italic> < 5.0x10<sup>-8</sup>.</p></sec><sec><title>Conclusion</title><p>In conclusion, this study provides the strongest evidence to date of a shared genetic susceptibility for IDC and DCIS. 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rid="Aff22"></xref></contrib><contrib contrib-type="author"><name><surname>Giles</surname><given-names>Graham G.</given-names></name><address><email>Graham.Giles@cancervic.org.au</email></address><xref ref-type="aff" rid="Aff21"></xref><xref ref-type="aff" rid="Aff22"></xref></contrib><contrib contrib-type="author"><name><surname>Margolin</surname><given-names>Sara</given-names></name><address><email>Sara.Margolin@karolinska.se</email></address><xref ref-type="aff" rid="Aff23"></xref></contrib><contrib contrib-type="author"><name><surname>Lindblom</surname><given-names>Annika</given-names></name><address><email>Annika.Lindblom@ki.se</email></address><xref ref-type="aff" rid="Aff24"></xref></contrib><contrib contrib-type="author"><name><surname>Brüning</surname><given-names>Thomas</given-names></name><address><email>bruening@ipa-dguv.de</email></address><xref ref-type="aff" rid="Aff25"></xref></contrib><contrib contrib-type="author"><name><surname>Brauch</surname><given-names>Hiltrud</given-names></name><address><email>hiltrud.brauch@ikp-stuttgart.de</email></address><xref ref-type="aff" rid="Aff26"></xref><xref ref-type="aff" rid="Aff27"></xref><xref ref-type="aff" rid="Aff28"></xref></contrib><contrib contrib-type="author"><name><surname>Southey</surname><given-names>Melissa C.</given-names></name><address><email>msouthey@unimelb.edu.au</email></address><xref ref-type="aff" rid="Aff29"></xref></contrib><contrib contrib-type="author"><name><surname>Hopper</surname><given-names>John L.</given-names></name><address><email>j.hopper@unimelb.edu.au</email></address><xref ref-type="aff" rid="Aff22"></xref></contrib><contrib contrib-type="author"><name><surname>Dörk</surname><given-names>Thilo</given-names></name><address><email>doerk.thilo@mh-hannover.de</email></address><xref ref-type="aff" rid="Aff30"></xref></contrib><contrib contrib-type="author"><name><surname>Bogdanova</surname><given-names>Natalia V.</given-names></name><address><email>bogdanova.natalia@mh-hannover.de</email></address><xref ref-type="aff" rid="Aff31"></xref></contrib><contrib contrib-type="author"><name><surname>Kabisch</surname><given-names>Maria</given-names></name><address><email>m.kabisch@dkfz.de</email></address><xref ref-type="aff" rid="Aff32"></xref></contrib><contrib contrib-type="author"><name><surname>Hamann</surname><given-names>Ute</given-names></name><address><email>u.hamann@dkfz-heidelberg.de</email></address><xref ref-type="aff" rid="Aff32"></xref></contrib><contrib contrib-type="author"><name><surname>Schmutzler</surname><given-names>Rita K.</given-names></name><address><email>rita.schmutzler@uk-koeln.de</email></address><xref ref-type="aff" rid="Aff33"></xref><xref ref-type="aff" rid="Aff34"></xref><xref ref-type="aff" rid="Aff35"></xref></contrib><contrib contrib-type="author"><name><surname>Meindl</surname><given-names>Alfons</given-names></name><address><email>alfons.meindl@lrz.tu-muenchen.de</email></address><xref ref-type="aff" rid="Aff36"></xref></contrib><contrib contrib-type="author"><name><surname>Brenner</surname><given-names>Hermann</given-names></name><address><email>h.brenner@dkfz.de</email></address><xref ref-type="aff" rid="Aff28"></xref><xref ref-type="aff" rid="Aff37"></xref><xref ref-type="aff" rid="Aff38"></xref></contrib><contrib contrib-type="author"><name><surname>Arndt</surname><given-names>Volker</given-names></name><address><email>v.arndt@dkfz.de</email></address><xref ref-type="aff" rid="Aff37"></xref></contrib><contrib contrib-type="author"><name><surname>Winqvist</surname><given-names>Robert</given-names></name><address><email>robert.winqvist@oulu.fi</email></address><xref ref-type="aff" rid="Aff39"></xref><xref ref-type="aff" rid="Aff40"></xref></contrib><contrib contrib-type="author"><name><surname>Pylkäs</surname><given-names>Katri</given-names></name><address><email>katri.pylkas@oulu.fi</email></address><xref ref-type="aff" rid="Aff39"></xref><xref ref-type="aff" rid="Aff40"></xref></contrib><contrib contrib-type="author"><name><surname>Fasching</surname><given-names>Peter A.</given-names></name><address><email>peter.fasching@uk-erlangen.de</email></address><xref ref-type="aff" rid="Aff41"></xref><xref ref-type="aff" rid="Aff42"></xref></contrib><contrib contrib-type="author"><name><surname>Beckmann</surname><given-names>Matthias W.</given-names></name><address><email>Fk-direktion@uk-erlangen.de</email></address><xref ref-type="aff" rid="Aff41"></xref></contrib><contrib contrib-type="author"><name><surname>Lubinski</surname><given-names>Jan</given-names></name><address><email>lubinski@pum.edu.pl</email></address><xref ref-type="aff" rid="Aff43"></xref></contrib><contrib contrib-type="author"><name><surname>Jakubowska</surname><given-names>Anna</given-names></name><address><email>aniaj@pum.edu.pl</email></address><xref ref-type="aff" rid="Aff43"></xref></contrib><contrib contrib-type="author"><name><surname>Mulligan</surname><given-names>Anna Marie</given-names></name><address><email>AnnaMarie.Mulligan@uhn.ca</email></address><xref ref-type="aff" rid="Aff44"></xref><xref ref-type="aff" rid="Aff45"></xref></contrib><contrib contrib-type="author"><name><surname>Andrulis</surname><given-names>Irene L.</given-names></name><address><email>andrulis@lunenfeld.ca</email></address><xref ref-type="aff" rid="Aff46"></xref><xref ref-type="aff" rid="Aff47"></xref></contrib><contrib contrib-type="author"><name><surname>Tollenaar</surname><given-names>Rob A. E. M.</given-names></name><address><email>r.a.e.m.tollenaar@lumc.nl</email></address><xref ref-type="aff" rid="Aff48"></xref></contrib><contrib contrib-type="author"><name><surname>Devilee</surname><given-names>Peter</given-names></name><address><email>p.devilee@lumc.nl</email></address><xref ref-type="aff" rid="Aff49"></xref><xref ref-type="aff" rid="Aff50"></xref></contrib><contrib contrib-type="author"><name><surname>Le Marchand</surname><given-names>Loic</given-names></name><address><email>loic@crch.hawaii.edu</email></address><xref ref-type="aff" rid="Aff51"></xref></contrib><contrib contrib-type="author"><name><surname>Haiman</surname><given-names>Christopher A.</given-names></name><address><email>Christopher.Haiman@med.usc.edu</email></address><xref ref-type="aff" rid="Aff52"></xref></contrib><contrib contrib-type="author"><name><surname>Mannermaa</surname><given-names>Arto</given-names></name><address><email>arto.mannermaa@uef.fi</email></address><xref ref-type="aff" rid="Aff53"></xref><xref ref-type="aff" rid="Aff54"></xref><xref ref-type="aff" rid="Aff55"></xref></contrib><contrib contrib-type="author"><name><surname>Kosma</surname><given-names>Veli-Matti</given-names></name><address><email>veli-matti.kosma@uef.fi</email></address><xref ref-type="aff" rid="Aff53"></xref><xref ref-type="aff" rid="Aff54"></xref><xref ref-type="aff" rid="Aff55"></xref></contrib><contrib contrib-type="author"><name><surname>Radice</surname><given-names>Paolo</given-names></name><address><email>paolo.radice@istitutotumori.mi.it</email></address><xref ref-type="aff" rid="Aff56"></xref></contrib><contrib contrib-type="author"><name><surname>Peterlongo</surname><given-names>Paolo</given-names></name><address><email>paolo.peterlongo@ifom.eu</email></address><xref ref-type="aff" rid="Aff57"></xref></contrib><contrib contrib-type="author"><name><surname>Marme</surname><given-names>Frederik</given-names></name><address><email>frederikmarme@gmail.com</email></address><xref ref-type="aff" rid="Aff58"></xref><xref ref-type="aff" rid="Aff59"></xref></contrib><contrib contrib-type="author"><name><surname>Burwinkel</surname><given-names>Barbara</given-names></name><address><email>Barbara.Burwinkel@med.uni-heidelberg.de</email></address><xref ref-type="aff" rid="Aff59"></xref><xref ref-type="aff" rid="Aff60"></xref></contrib><contrib contrib-type="author"><name><surname>van Deurzen</surname><given-names>Carolien H. M.</given-names></name><address><email>c.h.m.vandeurzen@erasmusmc.nl</email></address><xref ref-type="aff" rid="Aff61"></xref></contrib><contrib contrib-type="author"><name><surname>Hollestelle</surname><given-names>Antoinette</given-names></name><address><email>a.hollestelle@erasmusmc.nl</email></address><xref ref-type="aff" rid="Aff62"></xref></contrib><contrib contrib-type="author"><name><surname>Miller</surname><given-names>Nicola</given-names></name><address><email>nicola.miller@nuigalway.ie</email></address><xref ref-type="aff" rid="Aff63"></xref></contrib><contrib contrib-type="author"><name><surname>Kerin</surname><given-names>Michael J.</given-names></name><address><email>michael.kerin@nuigalway.ie</email></address><xref ref-type="aff" rid="Aff63"></xref></contrib><contrib contrib-type="author"><name><surname>Lambrechts</surname><given-names>Diether</given-names></name><address><email>Diether.Lambrechts@med.kuleuven.be</email></address><xref ref-type="aff" rid="Aff64"></xref><xref ref-type="aff" rid="Aff65"></xref></contrib><contrib contrib-type="author"><name><surname>Floris</surname><given-names>Giuseppe</given-names></name><address><email>Giuseppe.Floris@uzleuven.be</email></address><xref ref-type="aff" rid="Aff66"></xref></contrib><contrib contrib-type="author"><name><surname>Wesseling</surname><given-names>Jelle</given-names></name><address><email>j.wesseling@nki.nl</email></address><xref ref-type="aff" rid="Aff67"></xref></contrib><contrib contrib-type="author"><name><surname>Flyger</surname><given-names>Henrik</given-names></name><address><email>henrik.flyger@regionh.dk</email></address><xref ref-type="aff" rid="Aff68"></xref></contrib><contrib contrib-type="author"><name><surname>Bojesen</surname><given-names>Stig E.</given-names></name><address><email>stig.egil.bojesen@regionh.dk</email></address><xref ref-type="aff" rid="Aff69"></xref><xref ref-type="aff" rid="Aff70"></xref><xref ref-type="aff" rid="Aff71"></xref></contrib><contrib contrib-type="author"><name><surname>Yao</surname><given-names>Song</given-names></name><address><email>song.yao@roswellpark.org</email></address><xref ref-type="aff" rid="Aff72"></xref></contrib><contrib contrib-type="author"><name><surname>Ambrosone</surname><given-names>Christine B.</given-names></name><address><email>Christine.ambrosone@roswellpark.org</email></address><xref ref-type="aff" rid="Aff73"></xref></contrib><contrib contrib-type="author"><name><surname>Chenevix-Trench</surname><given-names>Georgia</given-names></name><address><email>Georgia.Trench@qimrberghofer.edu.au</email></address><xref ref-type="aff" rid="Aff74"></xref></contrib><contrib contrib-type="author"><name><surname>Truong</surname><given-names>Thérèse</given-names></name><address><email>therese.truong@inserm.fr</email></address><xref ref-type="aff" rid="Aff75"></xref><xref ref-type="aff" rid="Aff76"></xref></contrib><contrib contrib-type="author"><name><surname>Guénel</surname><given-names>Pascal</given-names></name><address><email>pascal.guenel@inserm.fr</email></address><xref ref-type="aff" rid="Aff75"></xref><xref ref-type="aff" rid="Aff76"></xref></contrib><contrib contrib-type="author"><name><surname>Rudolph</surname><given-names>Anja</given-names></name><address><email>a.rudolph@dkfz.de</email></address><xref ref-type="aff" rid="Aff77"></xref></contrib><contrib contrib-type="author"><name><surname>Chang-Claude</surname><given-names>Jenny</given-names></name><address><email>j.chang-claude@dkfz-heidelberg.de</email></address><xref ref-type="aff" rid="Aff77"></xref></contrib><contrib contrib-type="author"><name><surname>Nevanlinna</surname><given-names>Heli</given-names></name><address><email>Heli.Nevanlinna@hus.fi</email></address><xref ref-type="aff" rid="Aff78"></xref></contrib><contrib contrib-type="author"><name><surname>Blomqvist</surname><given-names>Carl</given-names></name><address><email>carl.blomqvist@helsinki.fi</email></address><xref ref-type="aff" rid="Aff79"></xref></contrib><contrib contrib-type="author"><name><surname>Czene</surname><given-names>Kamila</given-names></name><address><email>kamila.czene@ki.se</email></address><xref ref-type="aff" rid="Aff15"></xref></contrib><contrib contrib-type="author"><name><surname>Brand</surname><given-names>Judith S.</given-names></name><address><email>judith.brand@ki.se</email></address><xref ref-type="aff" rid="Aff15"></xref></contrib><contrib contrib-type="author"><name><surname>Olson</surname><given-names>Janet E.</given-names></name><address><email>olsonj@mayo.edu</email></address><xref ref-type="aff" rid="Aff80"></xref></contrib><contrib contrib-type="author"><name><surname>Couch</surname><given-names>Fergus J.</given-names></name><address><email>couch.fergus@mayo.edu</email></address><xref ref-type="aff" rid="Aff81"></xref></contrib><contrib contrib-type="author"><name><surname>Dunning</surname><given-names>Alison M.</given-names></name><address><email>amd24@medschl.cam.ac.uk</email></address><xref ref-type="aff" rid="Aff82"></xref></contrib><contrib contrib-type="author"><name><surname>Hall</surname><given-names>Per</given-names></name><address><email>Per.Hall@ki.se</email></address><xref ref-type="aff" rid="Aff15"></xref></contrib><contrib contrib-type="author"><name><surname>Easton</surname><given-names>Douglas F.</given-names></name><address><email>dfe20@medschl.cam.ac.uk</email></address><xref ref-type="aff" rid="Aff11"></xref><xref ref-type="aff" rid="Aff82"></xref></contrib><contrib contrib-type="author"><name><surname>Pharoah</surname><given-names>Paul D. P.</given-names></name><address><email>pp10001@medschl.cam.ac.uk</email></address><xref ref-type="aff" rid="Aff11"></xref><xref ref-type="aff" rid="Aff82"></xref></contrib><contrib contrib-type="author"><name><surname>Pinder</surname><given-names>Sarah E.</given-names></name><address><email>sarah.pinder@kcl.ac.uk</email></address><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Schmidt</surname><given-names>Marjanka K</given-names></name><address><email>mk.schmidt@nki.nl</email></address><xref ref-type="aff" rid="Aff67"></xref></contrib><contrib contrib-type="author"><name><surname>Tomlinson</surname><given-names>Ian</given-names></name><address><email>iant@well.ox.ac.uk</email></address><xref ref-type="aff" rid="Aff83"></xref></contrib><contrib contrib-type="author"><name><surname>Roylance</surname><given-names>Rebecca</given-names></name><address><email>r.roylance@qmul.ac.uk</email></address><xref ref-type="aff" rid="Aff4"></xref></contrib><contrib contrib-type="author"><name><surname>García-Closas</surname><given-names>Montserrat</given-names></name><address><email>montserrat.garcia-closas@nih.gov</email></address><xref ref-type="aff" rid="Aff3"></xref><xref ref-type="aff" rid="Aff16"></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Sawyer</surname><given-names>Elinor J.</given-names></name><address><phone>+44 (0) 20 7188 7843</phone><email>elinor.sawyer@kcl.ac.uk</email></address><xref ref-type="aff" rid="Aff1"></xref></contrib><aff id="Aff1"><label></label>Research Oncology, Guy’s Hospital, King’s College London, London, UK</aff><aff id="Aff2"><label></label>Medical and Molecular Genetics, Guy’s Hospital, King’s College London, London, UK</aff><aff id="Aff3"><label></label>Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK</aff><aff id="Aff4"><label></label>Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK</aff><aff id="Aff5"><label></label>Biomedical Research Centre, King’s College London, Guy’s Hospital, London, UK</aff><aff id="Aff6"><label></label>The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK</aff><aff id="Aff7"><label></label>Sheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield, UK</aff><aff id="Aff8"><label></label>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK</aff><aff id="Aff9"><label></label>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK</aff><aff id="Aff10"><label></label>Division of Breast Cancer Research, The Institute of Cancer Research, London, UK</aff><aff id="Aff11"><label></label>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</aff><aff id="Aff12"><label></label>Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain</aff><aff id="Aff13"><label></label>Centro de Investigación en Red de Enfermedades Raras, Valencia, Spain</aff><aff id="Aff14"><label></label>Centre d’innovation Génome Québec et Université McGill, Montréal, Canada</aff><aff id="Aff15"><label></label>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</aff><aff id="Aff16"><label></label>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD USA</aff><aff id="Aff17"><label></label>Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway</aff><aff id="Aff18"><label></label>K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway</aff><aff id="Aff19"><label></label>Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo, Norway</aff><aff id="Aff20"><label></label>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Canada</aff><aff id="Aff21"><label></label>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</aff><aff id="Aff22"><label></label>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne, VIC Australia</aff><aff id="Aff23"><label></label>Department of Oncology - Pathology, Karolinska Institutet, Stockholm, Sweden</aff><aff id="Aff24"><label></label>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden</aff><aff id="Aff25"><label></label>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum, Germany</aff><aff id="Aff26"><label></label>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany</aff><aff id="Aff27"><label></label>University of Tübingen, Tübingen, Germany</aff><aff id="Aff28"><label></label>German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="Aff29"><label></label>Department of Pathology, The University of Melbourne, Melbourne, Australia</aff><aff id="Aff30"><label></label>Gynaecology Research Unit, Hannover Medical School, Hannover, Germany</aff><aff id="Aff31"><label></label>Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</aff><aff id="Aff32"><label></label>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="Aff33"><label></label>Center for Familial Breast and Ovarian Cancer, Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany</aff><aff id="Aff34"><label></label>Center for Integrated Oncology (CIO), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany</aff><aff id="Aff35"><label></label>Center for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany</aff><aff id="Aff36"><label></label>Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany</aff><aff id="Aff37"><label></label>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="Aff38"><label></label>Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="Aff39"><label></label>Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland</aff><aff id="Aff40"><label></label>Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland</aff><aff id="Aff41"><label></label>Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany</aff><aff id="Aff42"><label></label>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA USA</aff><aff id="Aff43"><label></label>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</aff><aff id="Aff44"><label></label>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada</aff><aff id="Aff45"><label></label>Laboratory Medicine Program, University Health Network, Toronto, Canada</aff><aff id="Aff46"><label></label>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</aff><aff id="Aff47"><label></label>Department of Molecular Genetics, University of Toronto, Toronto, Canada</aff><aff id="Aff48"><label></label>Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands</aff><aff id="Aff49"><label></label>Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands</aff><aff id="Aff50"><label></label>Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands</aff><aff id="Aff51"><label></label>University of Hawaii Cancer Center, Honolulu, HI USA</aff><aff id="Aff52"><label></label>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA USA</aff><aff id="Aff53"><label></label>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</aff><aff id="Aff54"><label></label>Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</aff><aff id="Aff55"><label></label>Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland</aff><aff id="Aff56"><label></label>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan, Italy</aff><aff id="Aff57"><label></label>IFOM, Fondazione Istituto FIRC (Italian Foundation of Cancer Research) di Oncologia Molecolare, Milan, Italy</aff><aff id="Aff58"><label></label>National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</aff><aff id="Aff59"><label></label>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</aff><aff id="Aff60"><label></label>Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="Aff61"><label></label>Department of Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands</aff><aff id="Aff62"><label></label>Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands</aff><aff id="Aff63"><label></label>School of Medicine, National University of Ireland, Galway, Ireland</aff><aff id="Aff64"><label></label>Vesalius Research Center, VIB, Leuven, Belgium</aff><aff id="Aff65"><label></label>Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium</aff><aff id="Aff66"><label></label>University Hospital Gashuisberg, Leuven, Belgium</aff><aff id="Aff67"><label></label>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</aff><aff id="Aff68"><label></label>Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</aff><aff id="Aff69"><label></label>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</aff><aff id="Aff70"><label></label>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</aff><aff id="Aff71"><label></label>Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</aff><aff id="Aff72"><label></label>Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY USA</aff><aff id="Aff73"><label></label>Roswell Park Cancer Institute, Buffalo, NY USA</aff><aff id="Aff74"><label></label>Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia</aff><aff id="Aff75"><label></label>Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France</aff><aff id="Aff76"><label></label>University Paris-Sud, Villejuif, France</aff><aff id="Aff77"><label></label>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="Aff78"><label></label>Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland</aff><aff id="Aff79"><label></label>Department of Oncology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland</aff><aff id="Aff80"><label></label>Department of Health Sciences Research, Mayo Clinic, Rochester, MN USA</aff><aff id="Aff81"><label></label>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN USA</aff><aff id="Aff82"><label></label>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</aff><aff id="Aff83"><label></label>Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK</aff></contrib-group><pub-date pub-type="epub"><day>17</day><month>2</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>17</day><month>2</month><year>2016</year></pub-date><pub-date pub-type="ppub"><year>2016</year></pub-date><volume>18</volume><elocation-id>22</elocation-id><history><date date-type="received"><day>1</day><month>9</month><year>2015</year></date><date date-type="accepted"><day>6</day><month>1</month><year>2016</year></date></history><permissions><copyright-statement>© Petridis et al. 2016</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold>This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>) applies to the data made available in this article, unless otherwise stated.</license-p></license></permissions><abstract id="Abs1"><sec><title>Background</title><p>Ductal carcinoma <italic>in situ</italic> (DCIS) is a non-invasive form of breast cancer. It is often associated with invasive ductal carcinoma (IDC), and is considered to be a non-obligate precursor of IDC. It is not clear to what extent these two forms of cancer share low-risk susceptibility loci, or whether there are differences in the strength of association for shared loci.</p></sec><sec><title>Methods</title><p>To identify genetic polymorphisms that predispose to DCIS, we pooled data from 38 studies comprising 5,067 cases of DCIS, 24,584 cases of IDC and 37,467 controls, all genotyped using the iCOGS chip.</p></sec><sec><title>Results</title><p>Most (67 %) of the 76 known breast cancer predisposition loci showed an association with DCIS in the same direction as previously reported for invasive breast cancer. Case-only analysis showed no evidence for differences between associations for IDC and DCIS after considering multiple testing.</p><p>Analysis by estrogen receptor (ER) status confirmed that loci associated with ER positive IDC were also associated with ER positive DCIS. Analysis of DCIS by grade suggested that two independent SNPs at 11q13.3 near <italic>CCND1</italic> were specific to low/intermediate grade DCIS (rs75915166, rs554219). These associations with grade remained after adjusting for ER status and were also found in IDC.</p><p>We found no novel DCIS-specific loci at a genome wide significance level of <italic>P</italic> < 5.0x10<sup>-8</sup>.</p></sec><sec><title>Conclusion</title><p>In conclusion, this study provides the strongest evidence to date of a shared genetic susceptibility for IDC and DCIS. Studies with larger numbers of DCIS are needed to determine if IDC or DCIS specific loci exist.</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/s13058-016-0675-7) contains supplementary material, which is available to authorized users.</p></sec></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Ductal carcinoma in situ</kwd><kwd>Association study</kwd><kwd>Genetic predisposition</kwd><kwd>Common variants</kwd></kwd-group><funding-group><award-group><funding-source><institution-wrap><institution-id institution-id-type="FundRef">http://dx.doi.org/10.13039/501100000301</institution-id><institution>Breast Cancer Campaign (GB)</institution></institution-wrap></funding-source><award-id>2011NovPR49</award-id><principal-award-recipient><name><surname>Sawyer</surname><given-names>Elinor J.</given-names></name></principal-award-recipient></award-group><award-group><funding-source><institution-wrap><institution-id institution-id-type="FundRef">http://dx.doi.org/10.13039/501100000289</institution-id><institution>Cancer Research UK (GB)</institution></institution-wrap></funding-source><award-id>CRUK/08/046</award-id><principal-award-recipient><name><surname>Roylance</surname><given-names>Rebecca</given-names></name></principal-award-recipient></award-group><award-group><funding-source><institution>the European Community's Seventh Framework Programme</institution></funding-source><award-id>HEALTH-F2-2009-223175</award-id><principal-award-recipient><name><surname>Hall</surname><given-names>Per</given-names></name></principal-award-recipient></award-group><award-group><funding-source><institution-wrap><institution-id institution-id-type="FundRef">http://dx.doi.org/10.13039/501100000289</institution-id><institution>Cancer Research UK (GB)</institution></institution-wrap></funding-source><award-id>C1287/A10118</award-id><principal-award-recipient><name><surname>Easton</surname><given-names>Douglas F.</given-names></name></principal-award-recipient></award-group><award-group><funding-source><institution-wrap><institution-id institution-id-type="FundRef">http://dx.doi.org/10.13039/501100000289</institution-id><institution>Cancer Research UK (GB)</institution></institution-wrap></funding-source><award-id>C1287/A12014</award-id><principal-award-recipient><name><surname>Easton</surname><given-names>Douglas F.</given-names></name></principal-award-recipient></award-group></funding-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2016</meta-value></custom-meta></custom-meta-group></article-meta></front><body><sec id="Sec1" sec-type="introduction"><title>Background</title><p>Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive breast cancer including invasive ductal/no special type carcinomas (IDC). Since the introduction of screening mammography there has been a 7-fold increase in reported DCIS incidence in the USA, primarily in postmenopausal women [<xref ref-type="bibr" rid="CR1">1</xref>], with about 20 % of screen-detected tumors being DCIS [<xref ref-type="bibr" rid="CR2">2</xref>]. Approximately 45–78 % of all invasive breast cancers are associated with DCIS [<xref ref-type="bibr" rid="CR3">3</xref>, <xref ref-type="bibr" rid="CR4">4</xref>]. It is hypothesized in the majority of these cases that the invasive component has arisen from the DCIS as they generally share the same somatic genetic changes. The proportion of IDC associated with DCIS varies depending on subtype, with luminal and human epidermal growth factor receptor 2 (HER2)-positive IDC having more frequent DCIS (53 % and 63 %, respectively) than invasive basal breast cancers (33 %) [<xref ref-type="bibr" rid="CR5">5</xref>].</p><p>As most DCIS is treated surgically, the natural progression of untreated DCIS is not known. However, in one small study of patients with predominantly low-grade DCIS misdiagnosed as benign breast disease and who received no surgical intervention, 6 out of 13 patients developed ipsilateral invasive carcinoma with mean time to the development of invasive carcinoma being 9.0 years [<xref ref-type="bibr" rid="CR6">6</xref>]. In two specific DCIS trials in which DCIS was treated with breast-conserving surgery alone with no radiotherapy, long-term follow up shows that up to 30 % of women develop a recurrence (half of which will be DCIS and half invasive cancer) by 10 years [<xref ref-type="bibr" rid="CR7">7</xref>].</p><p>Methods for accurately predicting the behavior of DCIS are poor [<xref ref-type="bibr" rid="CR8">8</xref>]. Although grade has not been shown to be a good predictor of recurrence many clinicians use this classification to determine the use of radiotherapy following breast-conserving surgery. There is a strong correlation between the grade of the <italic>in situ</italic> and co-existing invasive components in IDC, suggesting that DCIS does not progress from low through to high grade before becoming invasive [<xref ref-type="bibr" rid="CR9">9</xref>, <xref ref-type="bibr" rid="CR10">10</xref>].</p><p>Most non-genetic risk factors for breast cancer have similar associations with DCIS and IDC, supporting the notion that DCIS is a precursor of invasive cancer [<xref ref-type="bibr" rid="CR11">11</xref>, <xref ref-type="bibr" rid="CR12">12</xref>]. There is also evidence from epidemiological studies that there is an inherited predisposition to DCIS. Women with DCIS have been shown to be 2.4 times (95 % CI 0.8, 7.2) more likely to have an affected mother and sister with breast cancer than controls [<xref ref-type="bibr" rid="CR13">13</xref>]. Furthermore, there is evidence from a study of almost 40,000 women that the familial relative risk of DCIS is greater than that of invasive breast cancer. For women aged 30–49 years with a family history of breast cancer the odds ratio (OR) for developing DCIS was calculated as 2.4 (95 % CI 1.1, 4.9) compared to 1.7 (95 % CI 0.9, 3.4) for invasive cancer. For women aged 50 years and above the risks were slightly reduced, but still higher for DCIS (OR = 2.2, 95 % CI 1.0, 4.2) than invasive disease (OR = 1.5, 95 % CI 1.0, 2.2) [<xref ref-type="bibr" rid="CR14">14</xref>]. However, this was not confirmed in the Million Women Study, in which the association with family history was similar for DCIS and IDC [<xref ref-type="bibr" rid="CR12">12</xref>].</p><p>A small part of this inherited predisposition is explained by <italic>BRCA1/2</italic> mutations, as mutations in these genes are found in a similar proportion of DCIS and invasive breast cancer cases [<xref ref-type="bibr" rid="CR15">15</xref>]. For low-risk common breast cancer predisposition alleles most of the initial breast cancer association studies have not been powered to identify associations with DCIS, so it is not clear whether all the low-risk susceptibility loci that have been identified are associated with DCIS and what the strength of any associations are.</p><p>It is now evident that some low-risk susceptibility loci are associated with different pathological subtypes of breast cancer and support the hypothesis that breast tumor subtypes arise through distinct molecular pathways [<xref ref-type="bibr" rid="CR16">16</xref>–<xref ref-type="bibr" rid="CR18">18</xref>]. In order to identify further low-risk susceptibility loci, it will be necessary to look at specific morphological subtypes including DCIS and the cytonuclear grade and estrogen receptor (ER) status of the disease. In this study we analyzed 3,078 cases of pure DCIS collected through the ICICLE study (a study to Investigate the genetics of In situ Carcinoma of the ductaL subtype) and performed a meta-analysis with 2,352 <italic>in situ</italic> cases collected through the Breast Cancer Association Consortium (BCAC). Our aims were to assess whether any of the known low-risk breast susceptibility alleles have different associations for DCIS and IDC, and to identify if there are any DCIS-specific low-risk alleles.</p></sec><sec id="Sec2" sec-type="materials|methods"><title>Methods</title><sec id="Sec3"><title>Ethics statement</title><p>All studies were performed with ethical committee approval (listed in acknowledgements) and subjects participated in the studies after providing informed consent.</p></sec><sec id="Sec4"><title>Study populations</title><p>Cases came from ICICLE (MREC 08/H0502/4), a UK study of DCIS, and from 37 studies forming part of the BCAC included in the Collaborative Oncological Gene-Environment Study (COGS) [<xref ref-type="bibr" rid="CR19">19</xref>] (Additional file <xref rid="MOESM1" ref-type="media">1</xref>). The ICICLE study recruited patients from participating centers throughout the UK with the aim of identifying predisposition genes for DCIS. Patients aged 60 years or less at the time of diagnosis, with a current or past history of DCIS (without invasive disease of any histological subtype) were eligible. A total of 3,078 subjects were recruited following identification from local pathology reports in 97 UK hospitals. All cases were genotyped with the iCOGS chip and compared to 5,000 UK controls selected from four UK studies (BBCS 1,231 controls, SBCS 704 controls, UKBGS 370 controls, SEARCH 2,695 controls) participating in BCAC (Additional file <xref rid="MOESM2" ref-type="media">2</xref>) and already typed on the iCOGS chip. Controls were randomly selected prior to analysis, and were excluded from case–control comparisons with BCAC cases from the originating study. After excluding individuals based on genotyping quality (see subsection “Genotyping and analysis”) and non-European ancestry, data for the ICICLE study available for analysis included 2,715 subjects with DCIS (cases) and 4,813 controls.</p><p>Women with all types of breast cancer were recruited into the BCAC studies. Pathological information in BCAC was collected in the individual studies but was also combined and checked through standardized data control in a central database. A total of 2,352 subjects with DCIS were identified in the central BCAC pathology database (see Additional file <xref rid="MOESM3" ref-type="media">3</xref> for number of cases by study). Controls came from the 37 BCAC studies (37,654 in total).</p></sec><sec id="Sec5"><title>Genotyping and analysis</title><p>After DNA extraction from peripheral blood, ICICLE samples were genotyped on the iCOGS custom Illumina iSelect array (Illumina, San Diego, CA), which contains 211,155 single nucleotide polymorphisms (SNPs), at King’s College London. The remaining cases and controls were genotyped as part of the COGS project described in detail elsewhere [<xref ref-type="bibr" rid="CR19">19</xref>]. The ICICLE cases were analyzed using the same quality control (QC) criteria as the COGS project. Briefly, genotypes were called using Illumina’s proprietary GenCall algorithm and 10,000 SNPs were manually inspected to verify the algorithm calls. Individuals were excluded if genotypically non-European or not female, or had an overall call rate <95 %. SNPs were excluded with a Gen-Train score <0.4, call rate <95 % (call rate <99 % if minor allele frequency (MAF) was <0.1) and Hardy Weinberg equilibrium (HWE) value of <italic>P</italic> <10<sup>-7</sup> or evidence of poor clustering on inspection of cluster plots. All SNPs with MAF <0.01 were excluded. A cryptic relatedness analysis of the whole dataset was performed using 46,789 uncorrelated SNPs and led to the exclusion of 28 cases and 18 controls due to relatedness between the ICICLE and BCAC samples (PIHAT >0.1875).</p><p>For ICICLE cases and controls, principal component analysis (PCA) was carried out on a subset of 46,789 uncorrelated SNPs and individuals or groups distinct from the main cluster (327 cases and 164 controls) were excluded using the first five principal components (PCs) (Additional file <xref rid="MOESM4" ref-type="media">4</xref>). Following removal of outliers, the PCA was repeated and the first five PCs were included as covariates in the analysis.</p><p>The adequacy of the case–control matching was evaluated using quantile-quantile plots of test statistics and the inflation factor (<italic>λ</italic>) calculated using 37,289 uncorrelated SNPs that were not selected by BCAC and were not within one of the four common fine-mapping regions, to minimize selection for SNPs associated with breast cancer (Additional file <xref rid="MOESM5" ref-type="media">5</xref>). As the majority of the SNPs on the iCOGS array are associated with breast, ovarian or prostate cancer, the SNPs selected for this analysis were taken from the set of prostate cancer SNPs, with the assumption that these SNPs were more likely to be representative of common SNPs in terms of population structure in our study.</p><p>For each SNP, we estimated a per-allele OR and reported corresponding 95 % CI using logistic regression analysis, including the five PCs as covariates, using PLINK v1.07 (<ext-link ext-link-type="uri" xlink:href="http://pngu.mgh.harvard.edu/~purcell/plink/">http://pngu.mgh.harvard.edu/~purcell/plink/</ext-link>).</p><p>Genotyping and analysis of BCAC studies have been described in detail elsewhere [<xref ref-type="bibr" rid="CR19">19</xref>]. In brief, data were analyzed using the Genotype Library and Utilities (GLU) package to estimate per-allele ORs for each SNP using unconditional logistic regression. All analyses were performed in subjects of European ancestry (determined by PC analyses) and adjusted for study and seven principal components.</p><p>Case–control ORs for DCIS cases vs controls from BCAC and ICICLE were combined using inverse variance-weighted fixed-effects meta-analysis, as implemented in METAL [<xref ref-type="bibr" rid="CR20">20</xref>]. Case-only analyses were also carried out to compare genotype frequencies for (1) ER-positive (ER+) vs ER-negative (ER–) DCIS, (2) high grade DCIS vs low and intermediate grade DCIS, and (3) DCIS vs IDC (see Additional file <xref rid="MOESM3" ref-type="media">3</xref> for number of cases by study), (4) DCIS diagnosis in patients <50 years of age vs DCIS diagnosis in patients ≥50 years, and were used as a test for heterogeneity of ORs by tumor subtype/age (see Additional file <xref rid="MOESM6" ref-type="media">6</xref> for number of cases by group). Only studies with data on both subtypes contributed to case-only analysis comparing these subtypes. Similar case-only analyses were performed for the IDC cases in these studies to assess whether any heterogeneity evident in DCIS also occurred in IDC.</p><p>Novel SNPs showing the strongest evidence of association with DCIS (<italic>P</italic> <6 × 10<sup>-6</sup>) in the meta-analysis (after excluding previously reported loci) were genotyped in a phase II analysis at LGC Genomics (LGC, Teddington, UK). The phase II samples consisted of 653 DCIS cases from the ICICLE and Breakthrough Generation Studies and 1,882 controls from the ICICLE study not previously genotyped on the iCOGS chip. All individuals included in the analysis were of European ancestry (self-reported).</p><p>For the known breast cancer predisposition loci <italic>P</italic> <0.00066 was considered statistically significant (with Bonferroni correction for multiple testing on 76 known loci). All of the known breast cancer susceptibility loci were included in the iCOGS chip with the exception of rs2284378 (20q11), which was identified as an ER– breast cancer predisposition SNP after the iCOGS chip was developed [<xref ref-type="bibr" rid="CR21">21</xref>].</p></sec><sec id="Sec6"><title>Assessment of grade and ER status</title><p>For the ICICLE study, information on cytonuclear grade of DCIS was available for 2,578 cases, mostly from the local histopathology reports. In 200 cases where the grade data were missing from the report but the tumor block was available, an H&E section was cut and the DCIS was graded by the study histopathologist (SEP) according to UK and College of American Pathologists guidelines [<xref ref-type="bibr" rid="CR22">22</xref>]. Data on grade of DCIS were available from histopathology reports for 828 BCAC cases.</p><p>A subset of 81 ICICLE cases, graded in the pathology report and with a tumor block available, were examined to assess the reliability of the cytonuclear grade provided by the pathology reports. In the majority of cases (86.5 %) grade was concordant with the pathology report. Nine cases were re-graded as low/intermediate grade and two cases as high grade. As the study pathologist re-graded the samples on a single H&E section, rather than all the blocks from an individual case, and in some cases on re-excision specimens with residual disease rather than the original excision specimen, the grade reported in the pathology report, if available, was used for the purposes of this study.</p><p>ER status from local histopathology reports was available for 1,086 ICICLE cases. For the remaining 781 ICICLE cases where the tumor block was available, immunohistochemistry was performed on 3-μM sections, which were incubated at 60 °C for 1 h prior to automated staining using the VENTANA®. Estrogen receptor staining was carried out using CONFIRM™ anti-estrogen receptor (SP1) rabbit monoclonal primary antibody (Catalog number 790-4324) with no variation to the recommended protocol. ER staining was scored by three independent reviewers (CP, VS, DLe) using the Allred method, and any discrepancies were reviewed by the study histopathologist (SEP). DCIS with an Allred score ≥3 was considered ER+ and DCIS with scores of 0–2 (approximately equivalent to <1 % of nuclei) was regarded as ER–. ER status was available on 965 cases from BCAC (Additional file <xref rid="MOESM6" ref-type="media">6</xref>).</p></sec></sec><sec id="Sec7" sec-type="results"><title>Results</title><sec id="Sec8"><title>Assessment of known breast cancer susceptibility loci for association with DCIS</title><p>For the majority of known loci (n = 46) the risk allele for invasive breast cancer is the minor allele. For the ORs presented here the reference allele was set as the non-risk allele to make it clear whether the association with DCIS was in the same direction as previously published for invasive breast cancer. Thus, ORs for DCIS will be >1 if in the same direction as invasive disease and <1 if in the opposite direction.</p><p>Of the 76 known common breast cancer susceptibility loci genotyped on the iCOGS array, 51 were associated with DCIS (<italic>P</italic> <0.05), with the effect in the same direction as previously reported in IDC (Fig. <xref rid="Fig1" ref-type="fig">1</xref> and Additional file <xref rid="MOESM7" ref-type="media">7</xref>). Sixteen SNPs were significantly associated with DCIS (<italic>P</italic> <0.00066) with three being genome-wide significant (<italic>P</italic> <5 × 10<sup>-8</sup>, Table <xref rid="Tab1" ref-type="table">1</xref>). The strongest associations were with for loci in <italic>FGFR2</italic> (rs2981579: OR 1.29, 95 % CI 1.24, 1.35; <italic>P</italic> = 9.0 × 10<sup>-30</sup>) and <italic>TOX3</italic> (rs3803662: OR 1.15, 95 % CI 1.1, 1.21; <italic>P</italic> = 1.7 × 10<sup>-8</sup>).<fig id="Fig1"><label>Fig. 1</label><caption><p>Known breast cancer predisposition loci for ductal carcinoma <italic>in situ</italic> plotted according to the risk allele for invasive disease. Odds ratios >1 indicate that the association is in the same direction as previously published for invasive breast cancer</p></caption><graphic xlink:href="13058_2016_675_Fig1_HTML" id="MO1"></graphic></fig><table-wrap id="Tab1"><label>Table 1</label><caption><p>Loci showing a significant association with ductal carcinoma <italic>in situ</italic> (DCIS) at <italic>P</italic> <0.00066</p></caption><table frame="hsides" rules="groups"><thead><tr><th>Chromosome</th><th>SNP</th><th>Locus</th><th>RAF</th><th colspan="3">DCIS vs controls (meta-analysis)</th><th colspan="3">IDC vs controls</th><th>Case-only DCIS vs IDC</th></tr><tr><th></th><th></th><th></th><th>Controls</th><th>OR</th><th>(95 % CI)</th><th><italic>P</italic></th><th>OR</th><th>(95 % CI)</th><th><italic>P</italic></th><th><italic>P</italic>-Het</th></tr></thead><tbody><tr><td>10</td><td>rs2981579</td><td>FGFR2</td><td>0.40</td><td>1.29</td><td>(1.24, 1.35)</td><td>9.0 × 10<sup>-30</sup></td><td>1.24</td><td>(1.21, 1.28)</td><td>6.1 × 10<sup>-66</sup></td><td>0.14</td></tr><tr><td>10</td><td>rs2981582</td><td>FGFR2</td><td>0.38</td><td>1.28</td><td>(1.23, 1.34)</td><td>1.8 × 10<sup>-27</sup></td><td>1.23</td><td>(1.20, 1.26)</td><td>2.1 × 10<sup>-59</sup></td><td>0.21</td></tr><tr><td>16</td><td>rs3803662</td><td>TOX3</td><td>0.26</td><td>1.15</td><td>(1.10, 1.21)</td><td>1.7 × 10<sup>-8</sup></td><td>1.23</td><td>(1.20, 1.27)</td><td>1.5 × 10<sup>-50</sup></td><td>0.69</td></tr><tr><td>5</td><td>rs889312</td><td>MAP3K1</td><td>0.28</td><td>1.14</td><td>(1.09, 1.20)</td><td>6.9 × 10<sup>-8</sup></td><td>1.11</td><td>(1.08, 1.14)</td><td>2.2 × 10<sup>-14</sup></td><td>0.13</td></tr><tr><td>3</td><td>rs4973768</td><td>SLC4A7</td><td>0.47</td><td>1.13</td><td>(1.08, 1.18)</td><td>9.1 × 10<sup>-8</sup></td><td>1.09</td><td>(1.07, 1.12)</td><td>8.2 × 10<sup>-13</sup></td><td>0.58</td></tr><tr><td>5</td><td>rs10941679</td><td>5p12</td><td>0.25</td><td>1.14</td><td>(1.09, 1.20)</td><td>1.3 × 10<sup>-7</sup></td><td>1.14</td><td>(1.11, 1.18)</td><td>1.2 × 10<sup>-20</sup></td><td>0.90</td></tr><tr><td>3</td><td>rs3821902</td><td>ATXN7</td><td>0.13</td><td>1.16</td><td>(1.09, 1.23)</td><td>3.0 × 10<sup>-6</sup></td><td>1.06</td><td>(1.02, 1.09)</td><td>0.0030</td><td>0.33</td></tr><tr><td>19</td><td>rs4808801</td><td>SSBP4</td><td>0.65</td><td>1.12</td><td>(1.06, 1.18)</td><td>3.1 × 10<sup>-6</sup></td><td>1.09</td><td>(1.05, 1.11)</td><td>3.5 × 10<sup>-9</sup></td><td>0.16</td></tr><tr><td>10</td><td>rs10995190</td><td>ZNF365</td><td>0.85</td><td>1.16</td><td>(1.09, 1.23)</td><td>4.1 × 10<sup>-6</sup></td><td>1.15</td><td>(1.11, 1.19)</td><td>7.5 × 10<sup>-16</sup></td><td>0.61</td></tr><tr><td>2</td><td>rs13387042</td><td>2q35</td><td>0.51</td><td>1.10</td><td>(1.05, 1.15)</td><td>1.1 × 10<sup>-5</sup></td><td>1.14</td><td>(1.11, 1.16)</td><td>8.3 × 10<sup>-25</sup></td><td>0.34</td></tr><tr><td>6</td><td>rs3757318</td><td>ESR1</td><td>0.07</td><td>1.20</td><td>(1.10, 1.30)</td><td>1.4 × 10<sup>-5</sup></td><td>1.16</td><td>(1.10, 1.21)</td><td>1.2 × 10<sup>-9</sup></td><td>0.85</td></tr><tr><td>11</td><td>rs554219</td><td>CCND1</td><td>0.12</td><td>1.15</td><td>(1.08, 1.22)</td><td>2.8 × 10<sup>-5</sup></td><td>1.27</td><td>(1.22, 1.32)</td><td>6.4 × 10<sup>-38</sup></td><td>0.88</td></tr><tr><td>6</td><td>rs2046210</td><td>ESR1</td><td>0.34</td><td>1.10</td><td>(1.05, 1.15)</td><td>8.6 × 10<sup>-5</sup></td><td>1.09</td><td>(1.06, 1.12)</td><td>4.0 × 10<sup>-10</sup></td><td>0.32</td></tr><tr><td>12</td><td>rs10771399</td><td>PTHLH</td><td>0.88</td><td>1.15</td><td>(1.06, 1.23)</td><td>0.00021</td><td>1.18</td><td>(1.12, 1.22)</td><td>1.2 × 10<sup>-14</sup></td><td>0.53</td></tr><tr><td>8</td><td>rs11780156</td><td>8q24.21</td><td>0.16</td><td>1.11</td><td>(1.05, 1.18)</td><td>0.00027</td><td>1.10</td><td>(1.06, 1.14)</td><td>2.3 × 10<sup>-8</sup></td><td>0.88</td></tr><tr><td>16</td><td>rs17817449</td><td>FTO</td><td>0.60</td><td>1.09</td><td>(1.03, 1.14)</td><td>0.00052</td><td>1.06</td><td>(1.04, 1.10)</td><td>5.9 × 10<sup>-7</sup></td><td>0.32</td></tr></tbody></table><table-wrap-foot><p><italic>SNP</italic> single nucleotide polymorphism, <italic>IDC</italic> invasive ductal carcinoma, <italic>OR</italic> odds ratio; <italic>P-He</italic>t <italic>P</italic> value for heterogeneity; <italic>RAF</italic> risk allele frequency</p></table-wrap-foot></table-wrap></p><p>The case-only analysis (DCIS vs IDC) confirmed the shared genetic susceptibility between DCIS and IDC as none of the heterogeneity <italic>P</italic> values (<italic>P</italic>-Het) were significant after Bonferroni adjustment for 76 SNPs (Additional file <xref rid="MOESM7" ref-type="media">7</xref>). The case-only analysis (DCIS diagnosed at <50 years vs ≥50 years of age) revealed one SNP (rs527616, 18q11.2) that was significantly associated with DCIS in younger women (<italic>P</italic>-Het<sub><50/≥50</sub> = 0.0003) even though the overall <italic>P</italic> value for DCIS was not statistically significant after Bonferroni correction (OR 1.05, 95 % CI 1.01, 1.11; <italic>P</italic> = 0.020) (Additional file <xref rid="MOESM8" ref-type="media">8</xref>).</p></sec><sec id="Sec9"><title>Assessment of known breast cancer susceptibility loci for association with DCIS by ER status</title><p>Following immunohistochemistry for ER in the ICICLE study samples, 1,484 cases (54 %) were classified as ER+ and 383 (14 %) as ER–. The ER data on BCAC DCIS were less complete with 664 (28 %) ER+, 301 (13 %) ER– and 1,387 cases (59 %) of unknown ER status (Additional file <xref rid="MOESM6" ref-type="media">6</xref>). Analysis by ER status confirmed that loci associated with ER+ IDC were also associated with ER+ DCIS (Fig. <xref rid="Fig2" ref-type="fig">2</xref> and Additional file <xref rid="MOESM9" ref-type="media">9</xref>). These similarities were less clear for ER– DCIS and ER– IDC but this may be due to small numbers of ER– DCIS cases. A case-only analysis of ER+ vs ER– DCIS was not performed due to the small numbers of ER– cases.<fig id="Fig2"><label>Fig. 2</label><caption><p>Known breast cancer predisposition loci for estrogen receptor-positive (ER+) (<italic>black lines</italic>) and ER– ductal carcinoma in situ (<italic>gray lines</italic>). Due to the large number of single nucleotide polymorphisms (<italic>SNPs</italic>), for better visual representation the plot is split into two different sections (<bold>a</bold> and <bold>b</bold>) with a descending order of effect size for the ER+ group. <italic>OR</italic> odds ratio</p></caption><graphic xlink:href="13058_2016_675_Fig2_HTML" id="MO2"></graphic></fig></p></sec><sec id="Sec10"><title>Assessment of known breast cancer susceptibility loci for association with DCIS by grade</title><p>Grade data were available for 95 % of ICICLE DCIS cases; 1,635 (60 %) were of high cytonuclear grade and 943 (35 %) of low/intermediate grade. The grade data on the BCAC DCIS were less complete with data only available for 35 % of cases: 306 (13 %) high grade and 522 (22 %) low/intermediate grade cases (Additional file <xref rid="MOESM6" ref-type="media">6</xref>). Case–control analysis was performed separately on the low/intermediate and high grade subsets and a case-only analysis of low/intermediate grade vs high grade DCIS was performed to assess whether any of these loci were grade-specific.</p><p>Analysis of DCIS by grade revealed that although the majority of SNPs predispose to all grades of DCIS, some are grade-specific (Additional files <xref rid="MOESM10" ref-type="media">10</xref> and <xref rid="MOESM11" ref-type="media">11</xref>). The two SNPs close to <italic>CCND1</italic> were strongly associated with low/intermediate grade DCIS (rs75915166, OR 1.36, 95 % CI 1.17, 1.59; <italic>P</italic> = 7.2 × 10<sup>-5</sup>; rs554219, OR 1.32, 95 % CI 1.18, 1.48; <italic>P</italic> = 8.2 × 10<sup>-7</sup>) and there was no association with high grade DCIS (Table <xref rid="Tab2" ref-type="table">2</xref>). Case-only analysis confirmed that these loci were low/intermediate grade-specific (rs75915166, <italic>P</italic>-Het<sub>low/highgrade</sub> = 0.00014; rs554219, <italic>P</italic>-Het<sub>low/highgrade</sub> = 0.00013) and this was independent of ER status (adjusted for ER status rs75915166, <italic>P</italic> = 0.0050; rs554219, <italic>P</italic> = 0.019).<table-wrap id="Tab2"><label>Table 2</label><caption><p>Association between rs75915166 or rs554219 and grade in ductal carcinoma <italic>in situ</italic></p></caption><table frame="hsides" rules="groups"><thead><tr><th rowspan="2" colspan="2"></th><th colspan="5">Meta-analysis</th></tr><tr><th>OR (95 % CI)</th><th><italic>P</italic></th><th>Low/intermediate grade, number</th><th>High grade, number</th><th>Controls, number</th></tr></thead><tbody><tr><td colspan="2">rs75915166</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td colspan="2">Low/intermediate grade vs controls</td><td>1.36 (1.17, 1.59)</td><td>7.2 × 10<sup>-5</sup></td><td>1,465</td><td></td><td>35,521</td></tr><tr><td colspan="2">High grade vs controls</td><td>0.92 (0.79, 1.08)</td><td>0.31</td><td></td><td>1,941</td><td>32,202</td></tr><tr><td colspan="2">Case-only high vs low/intermediate grade</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td>Unadjusted</td><td>0.68 (0.55, 0.83)</td><td>1.4 × 10<sup>-4</sup></td><td>1,307</td><td>1,941</td><td></td></tr><tr><td></td><td>unadjusted (only cases with ER status)</td><td>0.65 (0.51, 0.84)</td><td>1.1 × 10<sup>-3</sup></td><td>791</td><td>1,360</td><td></td></tr><tr><td></td><td>adjusted for ER status</td><td>0.68 (0.52, 0.89)</td><td>0.0050</td><td>791</td><td>1,360</td><td></td></tr><tr><td></td><td>ER+ only</td><td>0.68 (0.55, 0.84)</td><td>5 × 10<sup>-4</sup></td><td>709</td><td>985</td><td></td></tr><tr><td colspan="2">rs554219</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td colspan="2">Low/intermediate grade vs controls</td><td>1.32 (1.18, 1.48)</td><td>8.2 × 10<sup>-7</sup></td><td>1,465</td><td></td><td>35,521</td></tr><tr><td colspan="2">High grade vs controls</td><td>1.02 (0.91, 1.14)</td><td>0.75</td><td></td><td>1,941</td><td>32,202</td></tr><tr><td colspan="2">Case-only high vs low/intermediate grade</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td>Unadjusted</td><td>0.75 (0.65, 0.87)</td><td>1.3 × 10<sup>-4</sup></td><td>1,307</td><td>1,941</td><td></td></tr><tr><td></td><td>unadjusted (only cases with ER status)</td><td>0.75 (0.63, 0.88)</td><td>2.1 × 10<sup>-4</sup></td><td>791</td><td>1,360</td><td></td></tr><tr><td></td><td>adjusted for ER status</td><td>0.80 (0.67, 0.96)</td><td>0.019</td><td>792</td><td>1,360</td><td></td></tr><tr><td></td><td>ER+ only</td><td>0.76 (0.65, 0.89)</td><td>6.7 × 10<sup>-4</sup></td><td>709</td><td>985</td><td></td></tr></tbody></table><table-wrap-foot><p><italic>OR</italic> odds ratio, <italic>ER</italic> estrogen receptor</p></table-wrap-foot></table-wrap></p><p>A similar-case-only analysis of IDC by grade confirmed that the two SNPs on 11q13.3 close to <italic>CCND1</italic> were also invasive grade 1/2-specific in IDC (rs75915166, OR 1.42, <italic>P</italic> = 1.7 × 10<sup>-30</sup>, <italic>P</italic>-Het = 2.8 × 10<sup>-10</sup>; rs554219, OR 1.39, <italic>P</italic> = 4.7 × 10<sup>-49</sup>, <italic>P</italic>-Het = 1.3 × 10<sup>-17</sup>) and again were independent of ER status (<italic>P</italic> = 1.3 × 10<sup>-6</sup>, <italic>P</italic> = 1.6 × 10<sup>-6</sup>, respectively) (Additional file <xref rid="MOESM12" ref-type="media">12</xref>). In addition, other grade-specific loci were identified including three (rs2363956, rs8170 and rs10069690) specific to grade 3 invasive disease (Additional file <xref rid="MOESM13" ref-type="media">13</xref>).</p><p>rs10941679, 5p12 were borderline associated with low/intermediate grade DCIS (OR 1.26, <italic>P</italic> = 2.1 × 10<sup>-7</sup>, <italic>P</italic>-Het<sub>low/highgrade</sub> = 0.0033). This locus has previously been shown to be associated with low grade progesterone receptor (PR) + IDC [<xref ref-type="bibr" rid="CR23">23</xref>]. There was no evidence of any high grade DCIS specific loci (Additional file <xref rid="MOESM11" ref-type="media">11</xref>).</p></sec><sec id="Sec11"><title>Search for new DCIS predisposition loci</title><p>All SNPs that were genome-wide significant (<italic>P</italic> <5 × 10<sup>-8</sup>) in the meta-analysis were correlated with one of the known breast cancer predisposition loci. There were three SNPs that were not correlated with known loci at <italic>P</italic> <6 × 10<sup>-6</sup> (Table <xref rid="Tab3" ref-type="table">3</xref>), all with very little evidence of an association with IDC.<table-wrap id="Tab3"><label>Table 3</label><caption><p>Potential new ductal carcinoma <italic>in situ</italic> susceptibility loci</p></caption><table frame="hsides" rules="groups"><thead><tr><th>Single nucleotide polymorphism</th><th>rs12631593</th><th>rs13236351</th><th>rs73179023</th></tr></thead><tbody><tr><td>Chromosome</td><td>3</td><td>7</td><td>22</td></tr><tr><td>Position</td><td>60701884</td><td>97772513</td><td>43424477</td></tr><tr><td>Locus</td><td>FHIT</td><td>LMTK2</td><td>PACSIN2:TTLL1</td></tr><tr><td>Minor allele frequency</td><td>0.11</td><td>0.032</td><td>0.13</td></tr><tr><td colspan="2">ICICLE DCIS phase I</td><td></td><td></td></tr><tr><td>Odds ratio (95 % CI)</td><td>1.15 (1.04, 1.28)</td><td>1.31 (1.10, 1.56)</td><td>0.83 (0.75, 0.91)</td></tr><tr><td><italic>P</italic></td><td>0.0088</td><td>0.0029</td><td>0.00020</td></tr><tr><td colspan="2">BCAC DCIS</td><td></td><td></td></tr><tr><td>Odds ratio (95 % CI)</td><td>1.25 (1.14, 1.36)</td><td>1.3 (1.12, 1.51)</td><td>0.86 (0.79, 0.94)</td></tr><tr><td><italic>P</italic></td><td>1.0 × 10<sup>-6</sup></td><td>0.00060</td><td>0.0012</td></tr><tr><td colspan="2">Meta-analysis phase I</td><td></td><td></td></tr><tr><td>Odds ratio (95 % CI)</td><td>1.21 (1.13, 1.29)</td><td>1.3 (1.16, 1.46)</td><td>0.85 (0.79, 0.90)</td></tr><tr><td><italic>P</italic></td><td>5.5 × 10<sup>-8</sup></td><td>5.7 × 10<sup>-6</sup></td><td>1.1 × 10<sup>-6</sup></td></tr><tr><td colspan="2">Phase II DCIS</td><td></td><td></td></tr><tr><td>Odds ratio (95 % CI)</td><td>0.93 (0.76, 1.14)</td><td>0.91 (0.63, 1.31)</td><td>0.95 (0.78, 1.15)</td></tr><tr><td><italic>P</italic></td><td>0.49</td><td>0.61</td><td>0.57</td></tr><tr><td colspan="2">Meta-analysis phase II</td><td></td><td></td></tr><tr><td>Odds ratio (95 % CI)</td><td>1.18 (1.10, 1.25)</td><td>1.26 (1.13, 1.41)</td><td>0.86 (0.80, 0.91)</td></tr><tr><td><italic>P</italic></td><td>7.8 × 10<sup>-7</sup></td><td>2.9 × 10<sup>-5</sup></td><td>1.7 × 10<sup>-6</sup></td></tr><tr><td colspan="2">BCAC IDC</td><td></td><td></td></tr><tr><td>Odds ratio (95 % CI)</td><td>1.01 (0.97, 1.05)</td><td>1.05 (0.99, 1.13)</td><td>0.97 (0.93, 1.00)</td></tr><tr><td><italic>P</italic></td><td>0.54</td><td>0.13</td><td>0.060</td></tr><tr><td colspan="2">Case-only</td><td></td><td></td></tr><tr><td>DCIS vs IDC <italic>P</italic>-Het</td><td>0.0048</td><td>0.17</td><td>0.0099</td></tr></tbody></table><table-wrap-foot><p><italic>DCIS</italic> ductal carcinoma in situ, <italic>IDC</italic> invasive ductal carcinoma, <italic>BCAC</italic> Breast Cancer Association Consortium, <italic>ICICLE</italic> Study to investigate the genetics of in situ carcinoma of the ductal subtype, <italic>P</italic>-<italic>Het P</italic> value for heterogeneity</p></table-wrap-foot></table-wrap></p><p>Of these novel SNPs, rs12631593, 3p14.2, (an intronic variant in <italic>FHIT</italic>, chr3: 60726844) was the most strongly associated with DCIS (OR 1.21, 95 % CI 1.13, 1.29; <italic>P</italic> = 5.5 × 10<sup>-8</sup>). This SNP showed little association with IDC (OR 1.01, 95 % CI 0.97, 1.05; <italic>P</italic> = 0.54) and this was supported by the case-only analysis (<italic>P</italic>-Het<sub>DCIS/IDC</sub> = 0.0048).</p><p>The other loci were on 22q13.2, rs73179023 (DCIS only: OR 0.85, 95 % CI 0.79, 0.90; <italic>P</italic> = 1.1 × 10<sup>-6</sup>; IDC only: OR 0.97, 95 % CI 0.93, 1.00; <italic>P</italic> = 0.060, <italic>P</italic>-Het<sub>DCIS/IDC</sub> = 0.0099) and 7q21.3, rs13236351 (DCIS only: OR 1.30, 95 % CI 1.16, 1.46; <italic>P</italic> = 5.7 × 10<sup>-6</sup>; IDC only: OR 1.05, 95 % CI 0.99, 1.13; <italic>P</italic> = 0.13, <italic>P</italic>-Het<sub>DCIS/IDC</sub> = 0.17).</p><p>These SNPs were genotyped in a validation study including a further 653 DCIS cases and 1,882 controls, however, for all three loci there was no evidence of an association (for rs12631593, rs13236351, and rs73179023, <italic>P =</italic> 0.49, 0.61, and 0.57, respectively) and none were genome wide significant following a meta-analysis of all data (<italic>P</italic> = 7.8 × 10<sup>-7</sup>, 2.9 × 10<sup>-5</sup>, and 1.7 × 10<sup>-6</sup> respectively) (Table <xref rid="Tab3" ref-type="table">3</xref>).</p></sec></sec><sec id="Sec12" sec-type="discussion"><title>Discussion</title><p>This study provides the strongest evidence to date for a shared genetic susceptibility between DCIS and IDC, based on 5,067 cases with pure DCIS (no invasive disease) and 24,670 cases with IDC. It differs from previous BCAC analyses of DCIS, as it has included an additional 3,078 DCIS cases, excluded all cases of pure LCIS and has also compared DCIS to IDC rather than all invasive disease.</p><p>An important finding of this study is the lack of DCIS/IDC-specific loci among the known breast cancer predisposition loci. Of the five breast cancer predisposition alleles originally reported by Easton et al. [<xref ref-type="bibr" rid="CR24">24</xref>], three were shown to be associated with <italic>in situ</italic> (998 cases of DCIS and LCIS) disease (rs2981582-<italic>FGFR2</italic>, rs3803662-<italic>TOX3</italic>, rs889312-<italic>MAP3K1</italic>) with rs889312 showing a stronger association with DCIS (<italic>P</italic>-trend 0.007, per allele OR 1.30 for DCIS, per allele OR 1.13 for invasive disease). However, this finding of potential DCIS-specific loci was not confirmed in the Million women study which found no differential association with DCIS vs IDC for twelve breast cancer susceptibility loci, including rs889312, although their sample size was smaller (873 DCIS and 4,959 IDC) [<xref ref-type="bibr" rid="CR12">12</xref>]. In the recent BCAC COGS analysis all 41 novel SNPs identified on the iCOGS chip had comparable ORs for invasive and <italic>in situ</italic> disease (based on data from 2,335 in situ, and 42,118 invasive cases), with the exceptions of rs12493607 (<italic>TGFBR2</italic>), and rs3903072 (11q13.1), for which associations seemed to be restricted to invasive disease [<xref ref-type="bibr" rid="CR19">19</xref>]; however, we found no evidence of an IDC-specific association with these loci after correcting for multiple testing. A recent study investigating the association between 39 of the known breast cancer predisposition loci and breast cancer <italic>in situ</italic> (BCIS) suggested that rs1011970 (9p21.3, <italic>CDKN2BAS</italic>) had a stronger association with BCIS than invasive breast cancer (BC), <italic>P</italic>-Het<sub>BCIS/BC</sub> = 0.0065. This trend remained in a DCIS vs BC analysis (<italic>P</italic>-Het<sub>DCIS/BC</sub> = 0.021) [<xref ref-type="bibr" rid="CR25">25</xref>]. Our data, however, do not support this finding (DCIS OR 1.08, 95 % CI 1.02, 1.14; <italic>P</italic> = 0.011; IDC OR 1.05, 95 % CI 1.0, 1.09; <italic>P</italic> = 0.0025, <italic>P</italic>-Het<sub>DCIS/IDC</sub> = 0.33).</p><p>We have also shown for the first time that seven of the known invasive breast cancer predisposition loci not previously shown to be associated with DCIS have comparable ORs for IDC and DCIS: rs4973768 (<italic>SLC4A7),</italic> rs3821902 (<italic>ATXN7</italic>) [<xref ref-type="bibr" rid="CR26">26</xref>], rs10995190 (<italic>ZNF365</italic>), rs554219 (<italic>CCND1</italic>), rs3757318 and rs2046210 (<italic>ESR1</italic>).</p><p>This lack of DCIS/IDC-specific loci is in contrast to our previous study of lobular cancer in which we showed that there are loci that are specific to invasive lobular cancer (ILC), showing no association with lobular carcinoma in situ (LCIS) and there was also a suggestion of LCIS-specific loci [<xref ref-type="bibr" rid="CR16">16</xref>]. When we compare the DCIS data presented here to our previous LCIS analyses it reveals that there is some overlap between loci that are associated with ER+ DCIS and LCIS (Fig. <xref rid="Fig3" ref-type="fig">3</xref> and Additional file <xref rid="MOESM14" ref-type="media">14</xref>). However, there are also some differences: rs6678914, <italic>LGR6</italic> and rs865686, 9q31.2 are strongly associated with LCIS but there is little evidence of association with ER+ DCIS (<italic>P</italic>-Het<sub>DCIS/LCIS</sub> = 7.4 × 10<sup>-5</sup> and 6.6 × 10<sup>-4</sup>, respectively). We have also previously shown that rs11249433, 1p11.2 and rs11977670, 7q34 have a stronger association with invasive lobular cancer than IDC [<xref ref-type="bibr" rid="CR16">16</xref>]. These loci were only weakly associated with LCIS and were not associated with ER+ DCIS in this analysis.<fig id="Fig3"><label>Fig. 3</label><caption><p>Known breast cancer predisposition loci for estrogen receptor-positive (ER+) (<italic>black</italic>) ductal carcinoma <italic>in situ</italic> and lobular carcinoma <italic>in situ</italic> (<italic>gray</italic>). Due to the large number of single nucleotide polymorphisms (SNPs), for better visual representation, the plot is split into two different sections (<bold>a</bold> and <bold>b</bold>) with a descending order of effect size for the ER+ group. <italic>OR</italic> odds ratio</p></caption><graphic xlink:href="13058_2016_675_Fig3_HTML" id="MO3"></graphic></fig></p><p>Most association studies of invasive breast cancer involve subgroup analyses based on ER status. In contrast to invasive breast cancer, ER status in DCIS is not routinely assessed in all centers despite evidence from the NSABP B-24 trial of benefit from endocrine therapy in ER+ DCIS [<xref ref-type="bibr" rid="CR7">7</xref>]. A national audit of DCIS in the UK revealed that ER status was assessed in only 50 % of DCIS cases and ER positivity in low and intermediate grade DCIS was significantly more common than in high grade DCIS (<italic>P</italic> <0.001) (ER+ high grade 69 %, intermediate grade 94 %, low grade 99 %) [<xref ref-type="bibr" rid="CR27">27</xref>]. In order to overcome this issue we performed ER immunohistochemistry on the samples from ICICLE for which ER status was unknown. However, there was still a large amount of missing data on ER status in the BCAC cases, resulting in only 684 ER– DCIS cases being available for analysis, making it difficult to draw definitive conclusions about ER– DCIS. In essence the findings are similar to invasive breast cancer, with ER– and ER+ DCIS having different genetic susceptibility profiles and ER+ DCIS having a very similar profile to ER+ IDC.</p><p>Cytonuclear grade of DCIS is used by many clinicians to select those cases most likely to benefit from radiotherapy despite the fact that grade has not been shown to be a good predictor of recurrence. In the UK audit of DCIS, grade data were available for 99 % of DCIS cases, with 59 % classified as high grade, 29 % as intermediate and 11 % as low grade [<xref ref-type="bibr" rid="CR27">27</xref>]. Similarly, in our study data on grade were available for 95 % of cases in ICICLE. In invasive disease only a minority of predisposition loci have been shown to be grade specific; rs2981582 (<italic>FGFR2</italic>) and rs13281615 (8q24) [<xref ref-type="bibr" rid="CR28">28</xref>, <xref ref-type="bibr" rid="CR29">29</xref>] and rs10941679 (5p12) [<xref ref-type="bibr" rid="CR23">23</xref>]. We have shown that analysis of DCIS by grade reveals other known loci that are grade specific. The loci with the strongest association with grade were SNPs on 11q13, which had a stronger association with low/intermediate grade DCIS and IDC than high grade lesions. The finding of a strong association with low and intermediate grade ductal carcinomas that is independent of ER status in both DCIS and IDC for these loci is novel. rs614367 was the first locus on 11q13 shown to be associated with invasive breast cancer [<xref ref-type="bibr" rid="CR30">30</xref>]. Fine mapping of the region subsequently identified two independent signals (rs554219 and rs78540526, <italic>r</italic><sup>2</sup> = 0.38), which are the loci reported in this analysis. Functional analyses demonstrated that the risk variants modify enhancer and silencer elements, with the likely target gene being <italic>CCND1</italic> [<xref ref-type="bibr" rid="CR31">31</xref>].</p><p>A study of 150 cases of subsequent breast cancer (invasive and in situ) after DCIS observed significant association for both grade and ER status between the index DCIS and the subsequent breast cancer (whether ipsilateral or contralateral), suggesting that women with DCIS are at risk of developing subsequent breast cancers of a similar phenotype [<xref ref-type="bibr" rid="CR32">32</xref>]. This finding supports the genetic predisposition data presented here, with ER and grade-specific loci in DCIS having similar specificity in IDC.</p><p>Although we did not identify any novel loci that reached genome wide significance, we did identify three potential novel DCIS predisposition loci, two of which were DCIS-specific (rs12631593, rs73179023), and therefore need further investigation in other cohorts of DCIS. As at least 45 % of patients with IDC have associated DCIS present at diagnosis consistent with direct precursor behavior, it may seem biologically implausible that an SNP predisposes to DCIS but is not associated with IDC. However, it is possible that there is a subset of patients with DCIS with very low probability of progression. If the finding of DCIS-specific predisposition loci were confirmed in other studies, identifying such a subset of patients with low-risk DCIS would be clinically valuable.</p></sec><sec id="Sec13" sec-type="conclusion"><title>Conclusion</title><p>In conclusion this is the largest study to assess genetic predisposition in DCIS and shows that the majority of invasive breast cancer predisposition loci also predispose to DCIS. It highlights that, as for invasive disease, different SNPs predispose to ER+ and ER– DCIS. In addition it shows the importance of grade in both DCIS and IDC.</p></sec></body><back><app-group><app id="App1"><sec id="Sec14"><title>Additional files</title><p><media position="anchor" xlink:href="13058_2016_675_MOESM1_ESM.docx" id="MOESM1"><label>Additional file 1:</label><caption><p><bold>Study information for the Breast Cancer Association Consortium (</bold><bold><italic>BCAC</italic></bold><bold>) participating studies.</bold> (DOCX 28 kb)</p></caption></media><media position="anchor" xlink:href="13058_2016_675_MOESM2_ESM.docx" id="MOESM2"><label>Additional file 2:</label><caption><p><bold>Sample information for the SEARCH, UKBGS, SBCS, and BBCS studies.</bold> (DOCX 15 kb)</p></caption></media><media position="anchor" xlink:href="13058_2016_675_MOESM3_ESM.xlsx" id="MOESM3"><label>Additional file 3:</label><caption><p><bold>Number of studies and individuals included in analyses of ductal carcinoma</bold><bold><italic>in situ</italic></bold><bold><italic>(DCIS)</italic></bold><bold>and invasive ductal carcinoma</bold><bold><italic>(IDC)</italic></bold><bold>.</bold> BCAC Breast Cancer Association Consortium. (XLSX 12 kb)</p></caption></media><media position="anchor" xlink:href="13058_2016_675_MOESM4_ESM.pptx" id="MOESM4"><label>Additional file 4:</label><caption><p><bold>Principal component analysis (PCA) results from the study to investigate the genetics of</bold><bold><italic>in situ</italic></bold><bold>carcinoma of the ductal subtype</bold><bold><italic>(ICICLE)</italic></bold><bold>.</bold> (PPTX 142 kb)</p></caption></media><media position="anchor" xlink:href="13058_2016_675_MOESM5_ESM.pptx" id="MOESM5"><label>Additional file 5:</label><caption><p><bold>Quantile-quantile plots from the study to investigate the genetics of in situ carcinoma of the ductal subtype (</bold><bold><italic>ICICLE</italic></bold><bold>).</bold><italic>SNP</italic> single nucleotide polymorphism. (PPTX 125 kb)</p></caption></media><media position="anchor" xlink:href="13058_2016_675_MOESM6_ESM.docx" id="MOESM6"><label>Additional file 6:</label><caption><p><bold>Grade, estrogen receptor </bold><bold><italic>(ER)</italic></bold><bold>status, and age groups in patients with ductal carcinoma</bold><bold><italic>in situ</italic></bold><bold><italic>(DCIS)</italic></bold><bold>.</bold><italic>BCAC</italic> Breast Cancer Association Consortium, <italic>ICICLE</italic> study to investigate the genetics of <bold><italic>in situ</italic></bold> carcinoma of the ductal subtype. (DOCX 16 kb)</p></caption></media><media position="anchor" xlink:href="13058_2016_675_MOESM7_ESM.xlsx" id="MOESM7"><label>Additional file 7:</label><caption><p><bold>Association between ductal carcinoma</bold><bold><italic>in situ</italic></bold><bold><italic>(DCIS)</italic></bold><bold>and known breast cancer predisposition loci.</bold><italic>IDC</italic> invasive ductal carcinoma, <italic>P-Het P</italic> value for heterogeneity, <italic>SNP</italic> single nucleotide polymorphism, <italic>OR</italic> odds ratio. (XLSX 19 kb)</p></caption></media><media position="anchor" xlink:href="13058_2016_675_MOESM8_ESM.xlsx" id="MOESM8"><label>Additional file 8:</label><caption><p><bold>Age-specific case-only analysis of patients with ductal carcinoma</bold><bold><italic>in situ</italic></bold><bold>(DCIS) diagnosed at age <50 vs ≥50 years.</bold><italic>P-Het P</italic> value for heterogeneity, <italic>SNP</italic> single nucleotide polymorphism, <italic>OR</italic> odds ratio. (XLSX 17 kb)</p></caption></media><media position="anchor" xlink:href="13058_2016_675_MOESM9_ESM.xlsx" id="MOESM9"><label>Additional file 9:</label><caption><p><bold>Associations between the known breast cancer predisposition loci and estrogen receptor-positive </bold><bold><italic>(ER+)</italic></bold><bold> or ER– ductal carcinoma</bold><bold><italic>in situ</italic></bold><bold><italic>(DCIS)</italic></bold><bold>.</bold><italic>P-Het P</italic> value for heterogeneity, <italic>SNP</italic> single nucleotide polymorphism, <italic>OR</italic> odds ratio. (XLSX 19 kb)</p></caption></media><media position="anchor" xlink:href="13058_2016_675_MOESM10_ESM.zip" id="MOESM10"><label>Additional file 10:</label><caption><p><bold>a, b Known breast cancer predisposition loci for low/intermediate grade</bold><bold><italic>(black)</italic></bold><bold> and high grade ductal carcinoma</bold><bold><italic>in situ</italic></bold><bold>(DCIS)</bold><bold><italic>(gray)</italic></bold><bold>.</bold> Due to the large number of single nucleotide polymorphisms (<italic>SNP</italic>s), the plot is split for better visual representation into two different sections (a and b) with a descending order of effect size for the low/intermediate group. <italic>OR</italic> odds ratio. (ZIP 20 kb)</p></caption></media><media position="anchor" xlink:href="13058_2016_675_MOESM11_ESM.xlsx" id="MOESM11"><label>Additional file 11:</label><caption><p><bold>Associations of the known breast cancer predisposition loci for high and low-intermediate grade ductal carcinoma</bold><bold><italic>in situ</italic></bold><bold><italic>(DCIS)</italic></bold><bold>.</bold><italic>P-Het P</italic> value for heterogeneity, <italic>OR</italic> odds ratio. (XLSX 18 kb)</p></caption></media><media position="anchor" xlink:href="13058_2016_675_MOESM12_ESM.xlsx" id="MOESM12"><label>Additional file 12:</label><caption><p><bold>Association of rs75915166 and rs554219 with grade in invasive ductal carcinoma (</bold><bold><italic>IDC</italic></bold><bold>).</bold><italic>P-Het P</italic> value for heterogeneity, <italic>OR</italic> odds ratio. (XLSX 9 kb)</p></caption></media><media position="anchor" xlink:href="13058_2016_675_MOESM13_ESM.xlsx" id="MOESM13"><label>Additional file 13:</label><caption><p><bold>Associations between the known and novel breast cancer predisposition loci and invasive ductal cancer, by estrogen receptor (</bold><bold><italic>ER</italic></bold><bold>) status and grade.</bold><italic>OR</italic> odds ratio. (XLSX 24 kb)</p></caption></media><media position="anchor" xlink:href="13058_2016_675_MOESM14_ESM.xlsx" id="MOESM14"><label>Additional file 14:</label><caption><p><bold>Association between the known breast cancer predisposition loci and estrogen receptor-positive</bold><bold><italic>(ER+)</italic></bold><bold> ductal carcinoma</bold><bold><italic>in situ</italic></bold><bold><italic>(DCIS)</italic></bold><bold> or lobular carcinoma</bold><bold><italic>in situ</italic></bold><bold><italic>(LCIS)</italic></bold><bold>.</bold><italic>P-Het P</italic> value for heterogeneity, <italic>SNP</italic> single nucleotide polymorphism, <italic>OR</italic> odds ratio. (XLSX 19 kb)</p></caption></media></p></sec></app></app-group><glossary><title>Abbreviations</title><def-list><def-item><term>ABCS</term><def><p>Amsterdam Breast Cancer Study</p></def></def-item><def-item><term>BBBC</term><def><p>Bavarian Breast Cancer Cases and Controls</p></def></def-item><def-item><term>BBCS</term><def><p>British Breast Cancer Study</p></def></def-item><def-item><term>BC</term><def><p>breast cancer</p></def></def-item><def-item><term>BCAC</term><def><p>Breast Cancer Association Consortium</p></def></def-item><def-item><term>BCIS</term><def><p>breast carcinoma in situ</p></def></def-item><def-item><term>CI</term><def><p>confidence interval</p></def></def-item><def-item><term>COGS</term><def><p>Collaborative Oncological Gene-Environment Study</p></def></def-item><def-item><term>DCIS</term><def><p>ductal carcinoma in situ</p></def></def-item><def-item><term>ER</term><def><p>Estrogen receptor</p></def></def-item><def-item><term>H&E</term><def><p>hematoxylin and eosin</p></def></def-item><def-item><term>HWE</term><def><p>Hardy Weinberg equilibrium</p></def></def-item><def-item><term>ICICLE</term><def><p>study to investigate the genetics of in situ carcinoma of the ductal subtype</p></def></def-item><def-item><term>IDC</term><def><p>invasive ductal carcinoma</p></def></def-item><def-item><term>LCIS</term><def><p>lobular carcinoma in situ</p></def></def-item><def-item><term>MAF</term><def><p>minor allele frequency</p></def></def-item><def-item><term>OR</term><def><p>odds ratio</p></def></def-item><def-item><term>PCA</term><def><p>principal component analysis</p></def></def-item><def-item><term><italic>P</italic>-<italic>Het</italic></term><def><p><italic>P</italic> value for heterogeneity</p></def></def-item><def-item><term>SNP</term><def><p>single nucleotide polymorphism</p></def></def-item></def-list></glossary><fn-group><fn><p>Rebecca Roylance, Montserrat García-Closas and Elinor J. Sawyer are senior co-authors</p></fn><fn><p><bold>Competing interests</bold></p><p>The authors declare that there are no conflicts of interest.</p></fn><fn><p><bold>Authors’ contributions</bold></p><p>The study was conceived by ES and RR. Analysis and genotyping in ICICLE was performed by ES. Meta-analyses were performed by MGC. The manuscript was prepared by ES. EJS, RR and IT conceived and designed the experiments. CP, VS, DLe, EP, AGN, DCT, DV, FB, JD, and AMD performed the experiments. CP, MNB, MKB, QW, KM, IT, MGC, and EJS analyzed the data. CP, MNB, VS, KK, PGo, MC, DLe, EP, NO, AC, SSC, IdSS, JP, AS, MJS, MKB, QW, JD, KM, JB, AGN, DCT, DV, JLi, JF, VK, ALBD, PS, JS, RLM, GGG, SM, AL, TB, HBra, MCS, JLH, TD, NVB, MK, UH, RKS, AMe, HBre, VA, RW, KP, PAF, MWB, JLu, AJ, AMM, ILA, RAEMT, PD, LLM, CAH, AMa, VMK, PR, PP, FM, BB, CHMvD, AH, NM, MJK, DLa, GF, JW, HF, SEB, SY, CBA, GCT, TT, PGu, AR, JCC, HN, CB, KC, JSB, JEO, FJC, AMD, PH, DFE, PDPP, SEP, MKS, IT, RR, MGC, and EJS contributed reagents/materials/analysis tools. CP, IT, MGC, and EJS wrote the paper. SEP performed the histopathology review. CP, VS, DLe, and SEP performed ER scoring. CP, MNB, VS, KK, PGo, MC, DLe, EP, NO, AC, SSC, IdSS, JP, AS, MJS, MKB, QW, JD, KM, JB, AGN, DCT, DV, JLi, JF, VK, ALBD, PS, JS, RLM, GGG, SM, AL, TB, HBra, MCS, JLH, TD, NVB, MK, UH, RKS, AMe, HBre, VA, RW, KP, PAF, MWB, JLu, AJ, AMM, ILA, RAEMT, PD, LLM, CAH, AMa, VMK, PR, PP, FM, BB, CHMvD, AH, NM, MJK, DLa, GF, JW, HF, SEB, SY, CBA, GCT, TT, PGu, AR, JCC, HN, CB, KC, JSB, JEO, FJC, AMD, PH, DFE, PDPP, SEP, MKS, IT, RR, MGC, and EJS provided critical review of the manuscript. CP, MNB, VS, KK, PGo, MC, DLe, EP, NO, AC, SSC, IdSS, JP, AS, MJS, MKB, QW, JD, KM, JB, AGN, DCT, DV, JLi, JF, VK, ALBD, PS, JS, RLM, GGG, SM, AL, TB, HBra, MCS, JLH, TD, NVB, MK, UH, RKS, AMe, HBre, VA, RW, KP, PAF, MWB, JLu, AJ, AMM, ILA, RAEMT, PD, LLM, CAH AMa VMK PR PP FM BB CHMvD AH NM MJK DLa GF JW HF SEB SY CBA GCT TT, PGu, AR, JCC, HN, CB, KC, JSB, JEO, FJC, AMD, PH, DFE, PDPP, SEP, MKS, IT, RR, MGC, and EJS approved the final version of the manuscript.</p></fn><fn><p><bold>Authors’ information</bold></p><p>Study was conceived by ES & RR, analysis & genotyping of ICICLE performed by ES, meta-analyses performed by MGC, manuscript prepared by ES.</p></fn></fn-group><ack><title>Acknowledgements</title><p>We thank all the individuals who took part in these studies and all the researchers, clinicians, technicians and administrative staff who have enabled this work to be carried out. This study would not have been possible without the contributions of the following: Andrew Berchuck (OCAC), Rosalind A. Eeles, Ali Amin Al Olama, Zsofia Kote-Jarai, Sara Benlloch (PRACTICAL), Antonis Antoniou, Lesley McGuffog, Ken Offit (CIMBA), Andrew Lee, and Ed Dicks, Craig Luccarini and the staff of the Centre for Genetic Epidemiology Laboratory, the staff of the CNIO genotyping unit, Francois Bacot, Sylvie LaBoissière and Frederic Robidoux and the staff of the McGill University and Génome Québec Innovation Centre, Sune F. Nielsen, Borge G. Nordestgaard, and the staff of the Copenhagen DNA Laboratory, and Julie M. Cunningham, Sharon A. Windebank, Christopher A. Hilker, Jeffrey Meyer and the staff of Mayo Clinic Genotyping Core Facility. In particular, we thank: Maria Troy (ICICLE); the Swedish Medical Research Council (pKARMA); Siranoush Manoukian, Bernard Peissel, Daniela Zaffaroni and Jacopo Azzollini of the Fondazione IRCCS Istituto Nazionale dei Tumori (INT); Bernado Bonanni, Monica Barile and Irene Feroce of the Istituto Europeo di Oncologia (IEO), and the personnel of the Cogentech Cancer Genetic Test Laboratory (MBCSG); Emily Hallberg for contributions to sample and phenotype management (MCBCS); the SEARCH and EPIC teams, Kirsimari Aaltonen, Karl von Smitten, Sofia Khan, Tuomas Heikkinen, Irja Erkkilä (HEBCS); Petra Seibold, Dieter Flesch-Janys, Judith Heinz, Nadia Obi, Alina Vrieling, Sabine Behrens, Ursula Eilber, Muhabbet Celik, Til Olchers and Stefan Nickels (MARIE); Eileen Williams, Elaine Ryder-Mills, Kara Sargus (BBCS); Heather Thorne, Eveline Niedermayr, all the kConFab research nurses and staff, the heads and staff of the Family Cancer Clinics, and the Clinical Follow Up Study (which has received funding from the NHMRC, the National Breast Cancer Foundation, Cancer Australia, and the National Institute of Health (USA)) for their contributions to this resource, and the many families who contribute to kConFab; members of the Data Bank and Biorepository (DBBR) at Roswell Park Cancer Institute (RPCI) for providing biospecimens; staff and participants of the Copenhagen General Population Study and for the excellent technical assistance of Dorthe Uldall Andersen, Maria Birna Arnadottir, Anne Bank, Dorthe Kjeldgård Hansen (CGPS); Sten Cornelissen, Richard van Hien, Linde Braaf, Frans Hogervorst, Senno Verhoef, Laura van ‘t Veer, Emiel Rutgers, C Ellen van der Schoot, Femke Atsma (ABCS); Sue Higham, Helen Cramp, Ian Brock, Sabapathy Balasubramanian, Malcolm W.R. Reed and Dan Connley (SBCS); Breakthrough Breast Cancer and the Institute of Cancer Research for support and funding of the Breakthrough Generations Study, and the study participants, study staff, and the doctors, nurses and other health care providers and health information sources who have contributed to the study and acknowledge NHS funding to the Royal Marsden/ICR NIHR Biomedical Research Centre; Gilian Peuteman, Dominiek Smeets, Thomas Van Brussel and Kathleen Corthouts (LMBC); Niall McInerney, Gabrielle Colleran, Andrew Rowan, Angela Jones (BIGGS); Petra Bos, Jannet Blom, Ellen Crepin, Elisabeth Huijskens, Annette Heemskerk, the Erasmus MC Family Cancer Clinic (RBCS); Peter Bugert, Medical Faculty Mannheim (BSUCH); Eija Myöhänen, Helena Kemiläinen (KBCP); E. Krol-Warmerdam, and J. Blom for patient accrual, administering questionnaires, and managing clinical information, the LUMC survival data were retrieved from the Leiden hospital-based cancer registry system (ONCDOC) with the help of Dr. J. Molenaar (ORIGO); Guillermo Pita, Charo Alonso, Daniel Herrero, Nuria Álvarez, Pilar Zamora, Primitiva Menendez, the Human Genotyping-CEGEN Unit (CNIO); Teresa Selander, Nayana Weerasooriya (OFBCR); Arja Jukkola-Vuorinen, Mervi Grip, Saila Kauppila; Kari Mononen and Meeri Otsukka (OBCS); Hartwig Ziegler, Sonja Wolf, Christa Stegmaier, Katja Butterbach, Stefanie Engert, Heide Hellebrand, Sandra Kröber, Peter Hillemanns, Hans Christiansen and Johann H. Karstens (HMBCS); Maggie Angelakos, Judi Maskiell, Gillian Dite (ABCFS); The GENICA Network: Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, and University of Tübingen, Germany [HB, Wing-Yee Lo, Christina Justenhoven], German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ) (HB), Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, Germany (Yon-Dschun Ko, Christian Baisch), Institute of Pathology, University of Bonn, Germany (Hans-Peter Fischer), Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany (Ute Hamann), Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany (TB, Beate Pesch, Sylvia Rabstein, Anne Lotz); and Institute of Occupational Medicine and Maritime Medicine, University Medical Center Hamburg-Eppendorf, Germany (Volker Harth); Martine Tranchant (CHU de Québec Research Center), Marie-France Valois, Annie Turgeon and Lea Heguy (McGill University Health Center, Royal Victoria Hospital; McGill University) for DNA extraction, sample management and skillful technical assistance. JS is Chairholder of the Canada Research Chair in Oncogenetics (MTLGEBCS); Dr. Kristine Kleivi, PhD (K.G. Jebsen Centre for Breast Cancer Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway and Department of Research, Vestre Viken, Drammen, Norway), Dr. Lars Ottestad, MD (Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway), Prof. Em. Rolf Kåresen, MD (Department of Oncology, Oslo University Hospital and Faculty of Medicine, University of Oslo, Oslo, Norway), Dr. Anita Langerød, PhD (Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway), Dr. Ellen Schlichting, MD (Department for Breast and Endocrine Surgery, Oslo University Hospital Ullevaal, Oslo, Norway), Dr. Marit Muri Holmen, MD (Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway), Prof. Toril Sauer, MD (Department of Pathology at Akershus University hospital, Lørenskog, Norway), Dr. Vilde Haakensen, MD (Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway), Dr. Olav Engebråten, MD (Institute for Clinical Medicine, Faculty of Medicine, University of Oslo and Department of Oncology, Oslo University Hospital, Oslo, Norway), Prof. Bjørn Naume, MD (Division of Cancer Medicine and Radiotherapy, Department of Oncology, Oslo University Hospital Radiumhospitalet, Oslo, Norway), Dr. Cecile E. Kiserud, MD (National Advisory Unit on Late Effects after Cancer Treatment, Department of Oncology, Oslo University Hospital, Oslo, Norway and Department of Oncology, Oslo University Hospital, Oslo, Norway), Dr. Kristin V. Reinertsen, MD (National Advisory Unit on Late Effects after Cancer Treatment, Department of Oncology, Oslo University Hospital, Oslo, Norway and Department of Oncology, Oslo University Hospital, Oslo, Norway), Assoc. Prof. Åslaug Helland, MD (Department of Genetics, Institute for Cancer Research and Department of Oncology, Oslo University Hospital Radiumhospitalet, Oslo, Norway), Dr. Margit Riis, MD (Dept of Breast- and Endocrine Surgery, Oslo University Hospital, Ullevål, Oslo, Norway), Dr. Ida Bukholm, MD (Department of Breast-Endocrine Surgery, Akershus University Hospital, Oslo, Norway and Department of Oncology, Division of Cancer Medicine, Surgery and Transplantation, Oslo University Hospital, Oslo, Norway), Prof. Per Eystein Lønning, MD (Section of Oncology, Institute of Medicine, University of Bergen and Department of Oncology, Haukeland University Hospital, Bergen, Norway), Dr Silje Nord, PhD (Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway) and Grethe I. Grenaker Alnæs, M.Sc. (Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway) (NBCS); Louise Brinton, Mark Sherman, Neonila Szeszenia-Dabrowska, Beata Peplonska, Witold Zatonski, Pei Chao, and Michael Stagner (PBCS). kConFab/AOCS Investigators (Georgia.Trench@qimrberghofer.edu.au) Peter MacCallum Cancer Center, The University of Melbourne, Melbourne, Australia.</p><p>Funding was as follows: ICICLE genotyping was funded by the Breast Cancer Now (<ext-link ext-link-type="uri" xlink:href="http://breastcancernow.org/">http://breastcancernow.org/</ext-link>), and sample and data collection by Cancer Research UK. Core funding came from the National Institute for Health Research (NIHR) Biomedical Research Centre at Guy’s and St. Thomas’ NHS Foundation Trust and King’s College London and the Wellcome Trust Centre for Human Genetics (provided by the Wellcome Trust, 090532/Z/09/Z). The views expressed are those of the author(s) and not necessarily those of the NHS, NIHR or the Department of Health. BCAC is funded by Cancer Research UK (C1287/A10118, C1287/A12014) and by the European Community’s Seventh Framework Programme under grant agreement number 223175 (grant number HEALTH-F2-2009-223175) (COGS). Funding for the iCOGS infrastructure came from: the European Community’s Seventh Framework Programme under grant agreement number 223175 (HEALTH-F2-2009-223175) (COGS), Cancer Research UK (C1287/A10118, C1287/A 10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, C8197/A16565), the National Institutes of Health (CA128978) and Post-Cancer GWAS initiative (1U19 CA148537, 1U19 CA148065 and 1U19 CA148112 - the GAME-ON initiative), the Department of Defense (W81XWH-10-1-0341), the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer, Komen Foundation for the Cure, the Breast Cancer Research Foundation, and the Ovarian Cancer Research Fund. pKARMA was supported by Märit and Hans Rausings Initiative Against Breast Cancer. MCBCS was supported by the NIH grants CA128978, CA116167, CA176785 an NIH Specialized Program of Research Excellence (SPORE) in Breast Cancer (CA116201), and the Breast Cancer Research Foundation and a generous gift from the David F. and Margaret T. Grohne Family Foundation. SEARCH is funded by a programme grant from Cancer Research UK (C490/A10124) and supported by the UK National Institute for Health Research Biomedical Research Centre at the University of Cambridge. HEBCS was financially supported by the Helsinki University Central Hospital Research Fund, Academy of Finland (266528), the Finnish Cancer Society, The Nordic Cancer Union and the Sigrid Juselius Foundation. The MARIE study was supported by the Deutsche Krebshilfe e.V. (70-2892-BR I, 106332, 108253, 108419), the Hamburg Cancer Society, the German Cancer Research Centre (DKFZ) and the Federal Ministry of Education and Research (BMBF) Germany (01KH0402). The CECILE study was funded by Fondation de France, Institut National du Cancer (INCa), Ligue Nationale contre le Cancer, Ligue contre le Cancer Grand Ouest, Agence Nationale de Sécurité Sanitaire (ANSES), Agence Nationale de la Recherche (ANR). BBCS is funded by Cancer Research UK and Breakthrough Breast Cancer and acknowledges NHS funding to the NIHR Biomedical Research Centre, and the National Cancer Research Network (NCRN). kConFab is supported by a grant from the National Breast Cancer Foundation, and previously by the National Health and Medical Research Council (NHMRC), the Queensland Cancer Fund, the Cancer Councils of New South Wales, Victoria, Tasmania and South Australia, and the Cancer Foundation of Western Australia. Financial support for the AOCS was provided by the United States Army Medical Research and Materiel Command (DAMD17-01-1-0729), Cancer Council Victoria, Queensland Cancer Fund, Cancer Council New South Wales, Cancer Council South Australia, The Cancer Foundation of Western Australia, Cancer Council Tasmania and the National Health and Medical Research Council of Australia (NHMRC; 400413, 400281, 199600). GCT and PW are supported by the NHMRC. RB was a Cancer Institute NSW Clinical Research Fellow. TNBCC (RPCI) was supported by a Specialized Program of Research Excellence (SPORE) in Breast Cancer (CA116201), a grant from the Breast Cancer Research Foundation, a generous gift from the David F. and Margaret T. Grohne Family Foundation, and a Cancer Center Support Grant Shared Resource (P30 CA016056-32) for RPCI. The CGPS was supported by the Chief Physician Johan Boserup and Lise Boserup Fund, the Danish Medical Research Council and Herlev Hospital. The ABCS study was supported by the Dutch Cancer Society (grants NKI 2007-3839; 2009 4363); BBMRI-NL, which is a Research Infrastructure financed by the Dutch government (NWO 184.021.007); and the Dutch National Genomics Initiative. The SBCS was supported by Yorkshire Cancer Research S295, S299, S305PA and Sheffield Experimental Cancer Medicine Centre. The UKBGS is funded by Breast Cancer Now and the Institute of Cancer Research (ICR), London. ICR acknowledges NHS funding to the NIHR Biomedical Research Centre. LMBC is supported by the Stichting tegen Kanker (232-2008 and 196-2010). Diether Lambrechts is supported by the FWO and the KULPFV/10/016-SymBioSysII. RBCS was funded by the Dutch Cancer Society (DDHK 2004-3124, DDHK 2009-4318). The BSUCH study was supported by the Dietmar-Hopp Foundation, the Helmholtz Society and the German Cancer Research Center (DKFZ). MBCSG is supported by grants from the Italian Association for Cancer Research (AIRC) and by funds from the Italian citizens who allocated the 5/1000 share of their tax payment in support of the Fondazione IRCCS Istituto Nazionale Tumori, according to Italian laws (INT-Institutional strategic projects “5x1000”). KBCP was financially supported by the special Government Funding (EVO) of Kuopio University Hospital grants, Cancer Fund of North Savo, the Finnish Cancer Organizations, and by the strategic funding of the University of Eastern Finland. MEC was support by NIH grants CA63464, CA54281, CA098758 and CA132839. The ORIGO study was supported by the Dutch Cancer Society (RUL 1997-1505) and the Biobanking and Biomolecular Resources Research Infrastructure (BBMRI-NL CP16) The CNIO-BCS was supported by the Instituto de Salud Carlos III, the Red Temática de Investigación Cooperativa en Cáncer and grants from the Asociación Española Contra el Cáncer and the Fondo de Investigación Sanitario (PI11/00923 and PI12/00070). The Ontario Familial Breast Cancer Registry (OFBCR) was supported by grant UM1 CA164920 from the National Cancer Institute (USA). The content of this manuscript does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centers in the Breast Cancer Family Registry (BCFR), nor does mention of trade names, commercial products, or organizations imply endorsement by the USA Government or the BCFR. The SZBCS was supported by Grant PBZ_KBN_122/P05/2004 The work of the BBCC was partly funded by ELAN-Fond of the University Hospital of Erlangen. OBCS was supported by the Academy of Finland (grant number 250083, 122715 and Center of Excellence grant number 284605), the Finnish Cancer Foundation, the Sigrid Juselius Foundation, the University of Oulu, the University of Oulu Support Foundation and the special Governmental EVO funds for Oulu University Hospital-based research activities. The ESTHER study was supported by a grant from the Baden Württemberg Ministry of Science, Research and Arts. Additional cases were recruited in the context of the VERDI study, which was supported by a grant from the German Cancer Aid (Deutsche Krebshilfe). The GC-HBOC (German Consortium of Hereditary Breast and Ovarian Cancer) is supported by the German Cancer Aid (grant no 110837, coordinator: Rita K. Schmutzler). SKKDKFZS is supported by the DKFZ. HMBCS was supported by a grant from the Friends of Hannover Medical School and by the Rudolf Bartling Foundation. The Australian Breast Cancer Family Study (ABCFS) was supported by grant UM1 CA164920 from the National Cancer Institute (USA). The content of this manuscript does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centers in the Breast Cancer Family Registry (BCFR), nor does mention of trade names, commercial products, or organizations imply endorsement by the USA Government or the BCFR. The ABCFS is also supported by the National Health and Medical Research Council of Australia, the New South Wales Cancer Council, the Victorian Health Promotion Foundation (Australia) and the Victorian Breast Cancer Research Consortium. JLH is a National Health and Medical Research Council (NHMRC) Australia Fellow and a Victorian Breast Cancer Research Consortium Group Leader. MCS is a NHMRC Senior Research Fellow and a Victorian Breast Cancer Research Consortium Group Leader. GENICA was funded by the Federal Ministry of Education and Research (BMBF) Germany grants 01KW9975/5, 01KW9976/8, 01KW9977/0 and 01KW0114, the Robert Bosch Foundation, Stuttgart, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, the Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, and the Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, Germany. Financial support for KARBAC was provided through the regional agreement on medical training and clinical research (ALF) between Stockholm County Council and Karolinska Institutet, the Swedish Cancer Society, The Gustav V Jubilee foundation and and Bert von Kantzows foundation. MCCS cohort recruitment was funded by VicHealth and Cancer Council Victoria. The MCCS was further supported by Australian NHMRC grants 209057, 251553 and 504711 and by infrastructure provided by Cancer Council Victoria. Cases and their vital status were ascertained through the Victorian Cancer Registry (VCR). The work of MTLGEBCS was supported by the Quebec Breast Cancer Foundation, the Canadian Institutes of Health Research for the CIHR Team in Familial Risks of Breast Cancer programme - grant number CRN-87521 and the Ministry of Economic Development, Innovation and Export Trade - grant number PSR-SIIRI-701. The NBCS has received funding from the K.G. Jebsen Centre for Breast Cancer Research; the Research Council of Norway grant 193387/V50 (to A-L Børresen-Dale and V.N. Kristensen) and grant 193387/H10 (to A-L Børresen-Dale and V.N. Kristensen), South Eastern Norway Health Authority (grant 39346 to A-L Børresen-Dale) and the Norwegian Cancer Society (to A-L Børresen-Dale and V.N. Kristensen). PBCS was funded by Intramural Research Funds of the National Cancer Institute, Department of Health and Human Services, USA. The SASBAC study was supported by funding from the Agency for Science, Technology and Research of Singapore (A*STAR), the US National Institute of Health (NIH) and the Susan G. Komen Breast Cancer Foundation. Ethical approval bodies for BCAC studies are listed below.<table-wrap id="Taba"><table frame="hsides" rules="groups"><tbody><tr><td>ABCS</td><td>Leiden University Medical Center (LUMC) Commissie Medische Ethiek and Protocol Toetsingscommissie van het Nederlands Kanker Instituut/Antoni van Leeuwenhoek Ziekenhuis</td></tr><tr><td>BBCC</td><td>Friedrich-Alexander-Universitat Erlangen-Nurnberg Medizinische Fakultat Ethik-Commission</td></tr><tr><td>BBCS</td><td>South East Multi-Centre Research Ethics Committee</td></tr><tr><td>BIGGS</td><td>Galway University College Hospital Clinical Research Ethical Committee</td></tr><tr><td>BSUCH</td><td>Medizinische Fakultat Heidelberg Ethikkommission</td></tr><tr><td>CECILE</td><td>Comite Consultatif de Protection des Personnes dans la Recherche Biomedicale de Bicetre</td></tr><tr><td>CGPS</td><td>Kobenhavns Amt den Videnskabsetiske Komite</td></tr><tr><td>CNIO-BCS</td><td>Hospital Universitario La Paz Comite Etico de Investigacion Clinica</td></tr><tr><td>ESTHER</td><td>Ruprecht-Karls-Universitat Medizinische Fakultat Heidelberg Ethikkommission</td></tr><tr><td>GC-HBOC</td><td>Ethik-Kommission der Medizinischen Fakultat der Universitat zu Koln</td></tr><tr><td>HEBCS</td><td>Helsingin ja uudenmaan sairaanhoitopiiri (Helsinki University Central Hospital Ethics Committee)</td></tr><tr><td>HMBCS</td><td>Medizinische Hochschule Hannover Ethik-Kommission</td></tr><tr><td>ICICLE</td><td>Southampton and South West Hampshire Research Ethics Committee A (MREC 08/H0502/4)</td></tr><tr><td>KBCP</td><td>Pohjois-Savon Sairraanhoitopiirin Kuntayhtyma Tutkimuseettinen Toimikunta</td></tr><tr><td rowspan="2">kConFab/AOCS</td><td>kConFab: The Queenland Institute of Medical Research Human Research Ethics Committee (QIMR-HREC)</td></tr><tr><td>AOCS: Peter MacCallum Cancer Centre Ethics Committee</td></tr><tr><td>MARIE</td><td>Ruprecht-Karls-Universitat Medizinische Fakultat Heidelberg Ethikkommission</td></tr><tr><td>MBCSG</td><td>Comitato Etico Indipendente della Fondazione IRCCS “Istituto Nazionale dei Tumori”</td></tr><tr><td>MCBCS</td><td>Mayo Clinic IRB</td></tr><tr><td>MEC</td><td>University of Southern California Health Sciences Campus IRB</td></tr><tr><td>OBCS</td><td>Ethical Committee of the Medical Faculty of University of Oulu and Northern Ostrobothnia Hospital District Ethical Committee</td></tr><tr><td>OFBCR</td><td>Mount Sinai Hospital Research Ethics Board</td></tr><tr><td>ORIGO</td><td>Medical Ethical Committee and Board of Directors of the Leiden University Medical Center (LUMC)</td></tr><tr><td>pKARMA</td><td>Regionala Etikprovningsnamnden i Stockholm (Regional Ethical Review Board in Stockholm)</td></tr><tr><td>RBCS</td><td>Medische Ethische Toetsings Commissie Erasmus Medisch Centrum</td></tr><tr><td>SBCS</td><td>South Sheffield Research Ethics Committee</td></tr><tr><td>SEARCH</td><td>Multi Centre Research Ethics Committee 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