How important is gametocyte clearance after malaria therapy?
Identifieur interne : 000949 ( Pmc/Curation ); précédent : 000948; suivant : 000950How important is gametocyte clearance after malaria therapy?
Auteurs : Harin A. Karunajeewa [Australie] ; Ivo Mueller [France]Source :
- BMC Medicine [ 1741-7015 ] ; 2016.
Abstract
There has been increasing interest in the role of malaria drugs in preventing malaria transmission from humans to mosquitoes, which would help augment malaria control and elimination strategies. Nevertheless, only one stage in the malaria parasite life cycle, the gametocyte, is infectious to mosquitoes. The Worldwide Antimalarial Resistance Network (WWARN) have analyzed data from 48,840 patients from 141 clinical trials in order to define the nature and determinants of gametocyte clearance following artemisinin combination treatment (ACT) for symptomatic malaria infections. However, the presence of gametocytes does not always predict their infectivity, meaning that the microscopy-based methods used by the WWARN investigators represent an imperfect surrogate marker of transmissibility. Their findings, that some ACTs clear gametocytes faster than others, should be interpreted in light of these limitations and important gaps in our understanding of the biology and epidemiology of malaria transmission.
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DOI: 10.1186/s12916-016-0641-3
PubMed: 27317420
PubMed Central: 4912799
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Harin A. Karunajeewa<affiliation><nlm:aff id="Aff1">Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Vic 3052 Australia</nlm:aff><wicri:noCountry code="subfield">Vic 3052 Australia</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2">Western Centre for Health Research and Education, Western Health, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Western Centre for Health Research and Education, Western Health, Melbourne</wicri:regionArea></affiliation><affiliation><nlm:aff id="Aff1">Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Vic 3052 Australia</nlm:aff><wicri:noCountry code="subfield">Vic 3052 Australia</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3">Malaria: Parasites & Hosts Unit, Institut Pasteur, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Malaria: Parasites & Hosts Unit, Institut Pasteur, Paris</wicri:regionArea></affiliation>Le document en format XML
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Karunajeewa</name><affiliation><nlm:aff id="Aff1">Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Vic 3052 Australia</nlm:aff><wicri:noCountry code="subfield">Vic 3052 Australia</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2">Western Centre for Health Research and Education, Western Health, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Western Centre for Health Research and Education, Western Health, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Mueller, Ivo" sort="Mueller, Ivo" uniqKey="Mueller I" first="Ivo" last="Mueller">Ivo Mueller</name><affiliation><nlm:aff id="Aff1">Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Vic 3052 Australia</nlm:aff><wicri:noCountry code="subfield">Vic 3052 Australia</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3">Malaria: Parasites & Hosts Unit, Institut Pasteur, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Malaria: Parasites & Hosts Unit, Institut Pasteur, Paris</wicri:regionArea></affiliation></author></analytic><series><title level="j">BMC Medicine</title><idno type="eISSN">1741-7015</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>There has been increasing interest in the role of malaria drugs in preventing malaria transmission from humans to mosquitoes, which would help augment malaria control and elimination strategies. Nevertheless, only one stage in the malaria parasite life cycle, the gametocyte, is infectious to mosquitoes. The Worldwide Antimalarial Resistance Network (WWARN) have analyzed data from 48,840 patients from 141 clinical trials in order to define the nature and determinants of gametocyte clearance following artemisinin combination treatment (ACT) for symptomatic malaria infections. However, the presence of gametocytes does not always predict their infectivity, meaning that the microscopy-based methods used by the WWARN investigators represent an imperfect surrogate marker of transmissibility. Their findings, that some ACTs clear gametocytes faster than others, should be interpreted in light of these limitations and important gaps in our understanding of the biology and epidemiology of malaria transmission.</p><p>Please see related article: <ext-link ext-link-type="uri" xlink:href="https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-016-0621-7">https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-016-0621-7</ext-link></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Young, Ja" uniqKey="Young J">JA Young</name></author><author><name sortKey="Fivelman, Ql" uniqKey="Fivelman Q">QL Fivelman</name></author><author><name sortKey="Blair, Pl" uniqKey="Blair P">PL Blair</name></author><author><name sortKey="De La Vega, P" uniqKey="De La Vega P">P de la Vega</name></author><author><name sortKey="Le Roch, Kg" uniqKey="Le Roch K">KG Le 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<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Med</journal-id><journal-id journal-id-type="iso-abbrev">BMC Med</journal-id><journal-title-group><journal-title>BMC Medicine</journal-title></journal-title-group><issn pub-type="epub">1741-7015</issn><publisher><publisher-name>BioMed Central</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27317420</article-id><article-id pub-id-type="pmc">4912799</article-id><article-id pub-id-type="publisher-id">641</article-id><article-id pub-id-type="doi">10.1186/s12916-016-0641-3</article-id><article-categories><subj-group subj-group-type="heading"><subject>Commentary</subject></subj-group></article-categories><title-group><article-title>How important is gametocyte clearance after malaria therapy?</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Karunajeewa</surname><given-names>Harin A.</given-names></name><address><phone>+61 39345 2476</phone><phone>+61 40583 5317</phone><email>karunajeewa.h@wehi.edu.au</email></address><xref ref-type="aff" rid="Aff1"></xref><xref ref-type="aff" rid="Aff2"></xref></contrib><contrib contrib-type="author"><name><surname>Mueller</surname><given-names>Ivo</given-names></name><xref ref-type="aff" rid="Aff1"></xref><xref ref-type="aff" rid="Aff3"></xref></contrib><aff id="Aff1"><label></label>Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Vic 3052 Australia</aff><aff id="Aff2"><label></label>Western Centre for Health Research and Education, Western Health, Melbourne, Australia</aff><aff id="Aff3"><label></label>Malaria: Parasites & Hosts Unit, Institut Pasteur, Paris, France</aff></contrib-group><pub-date pub-type="epub"><day>18</day><month>6</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>18</day><month>6</month><year>2016</year></pub-date><pub-date pub-type="collection"><year>2016</year></pub-date><volume>14</volume><elocation-id>93</elocation-id><history><date date-type="received"><day>8</day><month>6</month><year>2016</year></date><date date-type="accepted"><day>9</day><month>6</month><year>2016</year></date></history><permissions><copyright-statement>© The Author(s). 2016</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold>This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>) applies to the data made available in this article, unless otherwise stated.</license-p></license></permissions><abstract id="Abs1"><p>There has been increasing interest in the role of malaria drugs in preventing malaria transmission from humans to mosquitoes, which would help augment malaria control and elimination strategies. Nevertheless, only one stage in the malaria parasite life cycle, the gametocyte, is infectious to mosquitoes. The Worldwide Antimalarial Resistance Network (WWARN) have analyzed data from 48,840 patients from 141 clinical trials in order to define the nature and determinants of gametocyte clearance following artemisinin combination treatment (ACT) for symptomatic malaria infections. However, the presence of gametocytes does not always predict their infectivity, meaning that the microscopy-based methods used by the WWARN investigators represent an imperfect surrogate marker of transmissibility. Their findings, that some ACTs clear gametocytes faster than others, should be interpreted in light of these limitations and important gaps in our understanding of the biology and epidemiology of malaria transmission.</p><p>Please see related article: <ext-link ext-link-type="uri" xlink:href="https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-016-0621-7">https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-016-0621-7</ext-link></p></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Malaria</kwd><kwd><italic>P. falciparum</italic></kwd><kwd>Antimalarial</kwd><kwd>Gametocytes</kwd><kwd>Gametocyte clearance</kwd><kwd>Artemisinin combination therapy</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2016</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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