Exercise during Short-Term and Long-Term Continuous Exposure to Hypoxia Exacerbates Sleep-Related Periodic Breathing
Identifieur interne : 000499 ( Pmc/Curation ); précédent : 000498; suivant : 000500Exercise during Short-Term and Long-Term Continuous Exposure to Hypoxia Exacerbates Sleep-Related Periodic Breathing
Auteurs : Helio Fernandez Tellez [Belgique] ; Shawnda A. Morrison [Slovénie] ; Xavier Neyt [Belgique] ; Olivier Mairesse [Belgique] ; Maria Francesca Piacentini [Belgique, Italie] ; Eoin Macdonald-Nethercott [Royaume-Uni, France] ; Andrej Pangerc [Slovénie] ; Leja Dolenc-Groselj [Slovénie] ; Ola Eiken [Suède] ; Nathalie Pattyn [Belgique] ; Igor B. Mekjavic [Slovénie] ; Romain Meeusen [Belgique, Australie]Source :
- Sleep [ 0161-8105 ] ; 2016.
Abstract
Exposure to hypoxia elevates chemosensitivity, which can lead to periodic breathing. Exercise impacts gas exchange, altering chemosensitivity; however, interactions between sleep, exercise and chronic hypoxic exposure have not been examined. This study investigated whether exercise exacerbates sleep-related periodic breathing in hypoxia.
Two experimental phases. Short-Term Phase: a laboratory controlled, group-design study in which 16 active, healthy men (age: 25 ± 3 y, height: 1.79 ± 0.06 m, mass: 74 ± 8 kg) were confined to a normobaric hypoxic environment (FIO2 = 0.139 ± 0.003, 4,000 m) for 10 days, after random assignment to a sedentary (control, CON) or cycle-exercise group (EX). Long-Term Phase: conducted at the Concordia Antarctic Research Station (3,800 m equivalent at the Equator) where 14 men (age: 36 ± 9 y, height: 1.77 ± 0.09 m, mass: 75 ± 10 kg) lived for 12–14 months, continuously confined. Participants were stratified post hoc based on self-reported physical activity levels. We quantified apnea-hypopnea index (AHI) and physical activity variables.
Short-Term Phase: mean AHI scores were significantly elevated in the EX group compared to CON (Night1 = CON: 39 ± 51, EX: 91 ± 59; Night10 = CON: 32 ± 32, EX: 92 ± 48; P = 0.046). Long-Term Phase: AHI was correlated to mean exercise time (R2 = 0.4857; P = 0.008) and the coefficient of variation in night oxyhemoglobin saturation (SpO2; R2 = 0.3062; P = 0.049).
Data indicate that exercise (physical activity)
Tellez HF, Morrison SA, Neyt X, Mairesse O, Piacentini MF, Macdonald-Nethercott E, Pangerc A, Dolenc-Groselj L, Eiken O, Pattyn N, Mekjavic IB, Meeusen R. Exercise during short-term and long-term continuous exposure to hypoxia exacerbates sleep-related periodic breathing.
Url:
DOI: 10.5665/sleep.5626
PubMed: 26951389
PubMed Central: 4791611
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Health Sciences, University of Rome Foro Italico, Rome</wicri:regionArea></affiliation></author><author><name sortKey="Macdonald Nethercott, Eoin" sort="Macdonald Nethercott, Eoin" uniqKey="Macdonald Nethercott E" first="Eoin" last="Macdonald-Nethercott">Eoin Macdonald-Nethercott</name><affiliation wicri:level="1"><nlm:aff id="aff7">JF Intensive Care Unit, Addenbrooke's Hospital, Cambridge, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>JF Intensive Care Unit, Addenbrooke's Hospital, Cambridge</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff8">Institut polaire français Paul-Emile Victor, Technopôle Brest-Iroise, Plouzané, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut polaire français Paul-Emile Victor, Technopôle Brest-Iroise, Plouzané</wicri:regionArea></affiliation></author><author><name sortKey="Pangerc, Andrej" sort="Pangerc, Andrej" uniqKey="Pangerc A" first="Andrej" last="Pangerc">Andrej Pangerc</name><affiliation wicri:level="1"><nlm:aff id="aff9">Institute of Clinical Neurophysiology, University Clinical Centre, Ljubljana, Slovenia</nlm:aff><country xml:lang="fr">Slovénie</country><wicri:regionArea>Institute of Clinical Neurophysiology, University Clinical Centre, Ljubljana</wicri:regionArea></affiliation></author><author><name sortKey="Dolenc Groselj, Leja" sort="Dolenc Groselj, Leja" uniqKey="Dolenc Groselj L" first="Leja" last="Dolenc-Groselj">Leja Dolenc-Groselj</name><affiliation wicri:level="1"><nlm:aff id="aff9">Institute of Clinical Neurophysiology, University Clinical Centre, Ljubljana, Slovenia</nlm:aff><country xml:lang="fr">Slovénie</country><wicri:regionArea>Institute of Clinical Neurophysiology, University Clinical Centre, Ljubljana</wicri:regionArea></affiliation></author><author><name sortKey="Eiken, Ola" sort="Eiken, Ola" uniqKey="Eiken O" first="Ola" last="Eiken">Ola Eiken</name><affiliation wicri:level="1"><nlm:aff id="aff10">Department of Environmental Physiology, Swedish Aerospace Physiology Centre, Royal Institute of Technology, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Environmental Physiology, Swedish Aerospace Physiology Centre, Royal Institute of Technology, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Pattyn, Nathalie" sort="Pattyn, Nathalie" uniqKey="Pattyn N" first="Nathalie" last="Pattyn">Nathalie Pattyn</name><affiliation wicri:level="1"><nlm:aff id="aff1">Vrije Universiteit Brussels, Human Physiology & Sports Medicine Department, Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Vrije Universiteit Brussels, Human Physiology & Sports Medicine Department, Brussels</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Royal Military Academy of Brussels, VIPER Research Unit, Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Royal Military Academy of Brussels, VIPER Research Unit, Brussels</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff11">Experimental and Applied Psychology Department, Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Experimental and Applied Psychology Department, Brussels</wicri:regionArea></affiliation></author><author><name sortKey="Mekjavic, Igor B" sort="Mekjavic, Igor B" uniqKey="Mekjavic I" first="Igor B." last="Mekjavic">Igor B. Mekjavic</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Automation, Biocybernetics, and Robotics, Jozef Stefan Institute, Ljubljana, Slovenia</nlm:aff><country xml:lang="fr">Slovénie</country><wicri:regionArea>Department of Automation, Biocybernetics, and Robotics, Jozef Stefan Institute, Ljubljana</wicri:regionArea></affiliation></author><author><name sortKey="Meeusen, Romain" sort="Meeusen, Romain" uniqKey="Meeusen R" first="Romain" last="Meeusen">Romain Meeusen</name><affiliation wicri:level="1"><nlm:aff id="aff1">Vrije Universiteit Brussels, Human Physiology & Sports Medicine Department, Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Vrije Universiteit Brussels, Human Physiology & Sports Medicine Department, Brussels</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff12">School of Public Health, Tropical Medicine and Health Sciences, James Cook University, Townsville City, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Public Health, Tropical Medicine and Health Sciences, James Cook University, Townsville City, Queensland</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26951389</idno><idno type="pmc">4791611</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791611</idno><idno type="RBID">PMC:4791611</idno><idno type="doi">10.5665/sleep.5626</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000499</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000499</idno><idno type="wicri:Area/Pmc/Curation">000499</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000499</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Exercise during Short-Term and Long-Term Continuous Exposure to Hypoxia Exacerbates Sleep-Related Periodic Breathing</title><author><name sortKey="Tellez, Helio Fernandez" sort="Tellez, Helio Fernandez" uniqKey="Tellez H" first="Helio Fernandez" last="Tellez">Helio Fernandez Tellez</name><affiliation wicri:level="1"><nlm:aff id="aff1">Vrije Universiteit Brussels, Human Physiology & Sports Medicine Department, Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Vrije Universiteit Brussels, Human Physiology & Sports Medicine Department, Brussels</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Royal Military Academy of Brussels, VIPER Research Unit, Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Royal Military Academy of Brussels, VIPER Research Unit, Brussels</wicri:regionArea></affiliation></author><author><name sortKey="Morrison, Shawnda A" sort="Morrison, Shawnda A" uniqKey="Morrison S" first="Shawnda A." last="Morrison">Shawnda A. Morrison</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Automation, Biocybernetics, and Robotics, Jozef Stefan Institute, Ljubljana, Slovenia</nlm:aff><country xml:lang="fr">Slovénie</country><wicri:regionArea>Department of Automation, Biocybernetics, and Robotics, Jozef Stefan Institute, Ljubljana</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff9">Institute of Clinical Neurophysiology, University Clinical Centre, Ljubljana, Slovenia</nlm:aff><country xml:lang="fr">Slovénie</country><wicri:regionArea>Institute of Clinical Neurophysiology, University Clinical Centre, Ljubljana</wicri:regionArea></affiliation></author><author><name sortKey="Neyt, Xavier" sort="Neyt, Xavier" uniqKey="Neyt X" first="Xavier" last="Neyt">Xavier Neyt</name><affiliation wicri:level="1"><nlm:aff id="aff2">Royal Military Academy of Brussels, VIPER Research Unit, Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Royal Military Academy of Brussels, VIPER Research Unit, Brussels</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4">Royal Military Academy Brussels, CISS, Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Royal Military Academy Brussels, CISS, Brussels</wicri:regionArea></affiliation></author><author><name sortKey="Mairesse, Olivier" sort="Mairesse, Olivier" uniqKey="Mairesse O" first="Olivier" last="Mairesse">Olivier Mairesse</name><affiliation wicri:level="1"><nlm:aff id="aff1">Vrije Universiteit Brussels, Human Physiology & Sports Medicine Department, Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Vrije Universiteit Brussels, Human Physiology & Sports Medicine Department, Brussels</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5">Sleep Laboratory & Unit for Chronobiology-Brugmann University Hospital Free University of Brussels (U.L.B./V.U.B), Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Sleep Laboratory & Unit for Chronobiology-Brugmann University Hospital Free University of Brussels (U.L.B./V.U.B), Brussels</wicri:regionArea></affiliation></author><author><name sortKey="Piacentini, Maria Francesca" sort="Piacentini, Maria Francesca" uniqKey="Piacentini M" first="Maria Francesca" last="Piacentini">Maria Francesca Piacentini</name><affiliation wicri:level="1"><nlm:aff id="aff1">Vrije Universiteit Brussels, Human Physiology & Sports Medicine Department, Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Vrije Universiteit Brussels, Human Physiology & Sports Medicine Department, Brussels</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6">Department of Movement, Human and Health Sciences, University of Rome Foro Italico, Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Movement, Human and Health Sciences, University of Rome Foro Italico, Rome</wicri:regionArea></affiliation></author><author><name sortKey="Macdonald Nethercott, Eoin" sort="Macdonald Nethercott, Eoin" uniqKey="Macdonald Nethercott E" first="Eoin" last="Macdonald-Nethercott">Eoin Macdonald-Nethercott</name><affiliation wicri:level="1"><nlm:aff id="aff7">JF Intensive Care Unit, Addenbrooke's Hospital, Cambridge, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>JF Intensive Care Unit, Addenbrooke's Hospital, Cambridge</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff8">Institut polaire français Paul-Emile Victor, Technopôle Brest-Iroise, Plouzané, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut polaire français Paul-Emile Victor, Technopôle Brest-Iroise, Plouzané</wicri:regionArea></affiliation></author><author><name sortKey="Pangerc, Andrej" sort="Pangerc, Andrej" uniqKey="Pangerc A" first="Andrej" last="Pangerc">Andrej Pangerc</name><affiliation wicri:level="1"><nlm:aff id="aff9">Institute of Clinical Neurophysiology, University Clinical Centre, Ljubljana, Slovenia</nlm:aff><country xml:lang="fr">Slovénie</country><wicri:regionArea>Institute of Clinical Neurophysiology, University Clinical Centre, Ljubljana</wicri:regionArea></affiliation></author><author><name sortKey="Dolenc Groselj, Leja" sort="Dolenc Groselj, Leja" uniqKey="Dolenc Groselj L" first="Leja" last="Dolenc-Groselj">Leja Dolenc-Groselj</name><affiliation wicri:level="1"><nlm:aff id="aff9">Institute of Clinical Neurophysiology, University Clinical Centre, Ljubljana, Slovenia</nlm:aff><country xml:lang="fr">Slovénie</country><wicri:regionArea>Institute of Clinical Neurophysiology, University Clinical Centre, Ljubljana</wicri:regionArea></affiliation></author><author><name sortKey="Eiken, Ola" sort="Eiken, Ola" uniqKey="Eiken O" first="Ola" last="Eiken">Ola Eiken</name><affiliation wicri:level="1"><nlm:aff id="aff10">Department of Environmental Physiology, Swedish Aerospace Physiology Centre, Royal Institute of Technology, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Environmental Physiology, Swedish Aerospace Physiology Centre, Royal Institute of Technology, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Pattyn, Nathalie" sort="Pattyn, Nathalie" uniqKey="Pattyn N" first="Nathalie" last="Pattyn">Nathalie Pattyn</name><affiliation wicri:level="1"><nlm:aff id="aff1">Vrije Universiteit Brussels, Human Physiology & Sports Medicine Department, Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Vrije Universiteit Brussels, Human Physiology & Sports Medicine Department, Brussels</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Royal Military Academy of Brussels, VIPER Research Unit, Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Royal Military Academy of Brussels, VIPER Research Unit, Brussels</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff11">Experimental and Applied Psychology Department, Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Experimental and Applied Psychology Department, Brussels</wicri:regionArea></affiliation></author><author><name sortKey="Mekjavic, Igor B" sort="Mekjavic, Igor B" uniqKey="Mekjavic I" first="Igor B." last="Mekjavic">Igor B. Mekjavic</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Automation, Biocybernetics, and Robotics, Jozef Stefan Institute, Ljubljana, Slovenia</nlm:aff><country xml:lang="fr">Slovénie</country><wicri:regionArea>Department of Automation, Biocybernetics, and Robotics, Jozef Stefan Institute, Ljubljana</wicri:regionArea></affiliation></author><author><name sortKey="Meeusen, Romain" sort="Meeusen, Romain" uniqKey="Meeusen R" first="Romain" last="Meeusen">Romain Meeusen</name><affiliation wicri:level="1"><nlm:aff id="aff1">Vrije Universiteit Brussels, Human Physiology & Sports Medicine Department, Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Vrije Universiteit Brussels, Human Physiology & Sports Medicine Department, Brussels</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff12">School of Public Health, Tropical Medicine and Health Sciences, James Cook University, Townsville City, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Public Health, Tropical Medicine and Health Sciences, James Cook University, Townsville City, Queensland</wicri:regionArea></affiliation></author></analytic><series><title level="j">Sleep</title><idno type="ISSN">0161-8105</idno><idno type="eISSN">1550-9109</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Study Objectives:</title><p>Exposure to hypoxia elevates chemosensitivity, which can lead to periodic breathing. Exercise impacts gas exchange, altering chemosensitivity; however, interactions between sleep, exercise and chronic hypoxic exposure have not been examined. This study investigated whether exercise exacerbates sleep-related periodic breathing in hypoxia.</p></sec><sec><title>Methods:</title><p>Two experimental phases. Short-Term Phase: a laboratory controlled, group-design study in which 16 active, healthy men (age: 25 ± 3 y, height: 1.79 ± 0.06 m, mass: 74 ± 8 kg) were confined to a normobaric hypoxic environment (FIO2 = 0.139 ± 0.003, 4,000 m) for 10 days, after random assignment to a sedentary (control, CON) or cycle-exercise group (EX). Long-Term Phase: conducted at the Concordia Antarctic Research Station (3,800 m equivalent at the Equator) where 14 men (age: 36 ± 9 y, height: 1.77 ± 0.09 m, mass: 75 ± 10 kg) lived for 12–14 months, continuously confined. Participants were stratified post hoc based on self-reported physical activity levels. We quantified apnea-hypopnea index (AHI) and physical activity variables.</p></sec><sec><title>Results:</title><p>Short-Term Phase: mean AHI scores were significantly elevated in the EX group compared to CON (Night1 = CON: 39 ± 51, EX: 91 ± 59; Night10 = CON: 32 ± 32, EX: 92 ± 48; P = 0.046). Long-Term Phase: AHI was correlated to mean exercise time (R<sup>2</sup> = 0.4857; P = 0.008) and the coefficient of variation in night oxyhemoglobin saturation (SpO2; R<sup>2</sup> = 0.3062; P = 0.049).</p></sec><sec><title>Conclusions:</title><p>Data indicate that exercise (physical activity) <italic>per se</italic> affects night SpO2 concentrations and AHI after a minimum of two bouts of moderate-intensity hypoxic exercise, while habitual physical activity in hypobaric hypoxic confinement affects breathing during sleep, up to 13+ months' duration</p></sec><sec><title>Citation:</title><p>Tellez HF, Morrison SA, Neyt X, Mairesse O, Piacentini MF, Macdonald-Nethercott E, Pangerc A, Dolenc-Groselj L, Eiken O, Pattyn N, Mekjavic IB, Meeusen R. Exercise during short-term and long-term continuous exposure to hypoxia exacerbates sleep-related periodic breathing. <italic>SLEEP</italic> 2016;39(4):773–783.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Sleep</journal-id><journal-id journal-id-type="iso-abbrev">Sleep</journal-id><journal-id journal-id-type="publisher-id">Sleep</journal-id><journal-title-group><journal-title>Sleep</journal-title></journal-title-group><issn pub-type="ppub">0161-8105</issn><issn pub-type="epub">1550-9109</issn><publisher><publisher-name>Associated Professional Sleep Societies, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26951389</article-id><article-id pub-id-type="pmc">4791611</article-id><article-id pub-id-type="publisher-id">sp-00279-15</article-id><article-id pub-id-type="doi">10.5665/sleep.5626</article-id><article-categories><subj-group subj-group-type="heading"><subject>Sleep Disordered Breathing</subject></subj-group></article-categories><title-group><article-title>Exercise during Short-Term and Long-Term Continuous Exposure to Hypoxia Exacerbates Sleep-Related Periodic Breathing</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Tellez</surname><given-names>Helio Fernandez</given-names></name><degrees>MEng</degrees><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="author-notes" rid="FN1">*</xref><xref ref-type="corresp" rid="cor1"></xref></contrib><contrib contrib-type="author"><name><surname>Morrison</surname><given-names>Shawnda A.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><xref ref-type="aff" rid="aff9"><sup>9</sup></xref><xref ref-type="author-notes" rid="FN1">*</xref></contrib><contrib contrib-type="author"><name><surname>Neyt</surname><given-names>Xavier</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mairesse</surname><given-names>Olivier</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Piacentini</surname><given-names>Maria Francesca</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff6"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Macdonald-Nethercott</surname><given-names>Eoin</given-names></name><degrees>MBBChir</degrees><xref ref-type="aff" rid="aff7"><sup>7</sup></xref><xref ref-type="aff" rid="aff8"><sup>8</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pangerc</surname><given-names>Andrej</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff9"><sup>9</sup></xref></contrib><contrib contrib-type="author"><name><surname>Dolenc-Groselj</surname><given-names>Leja</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="aff9"><sup>9</sup></xref></contrib><contrib contrib-type="author"><name><surname>Eiken</surname><given-names>Ola</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="aff10"><sup>10</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pattyn</surname><given-names>Nathalie</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff11"><sup>11</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mekjavic</surname><given-names>Igor B.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Meeusen</surname><given-names>Romain</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff12"><sup>12</sup></xref></contrib><aff id="aff1"><label>1</label>Vrije Universiteit Brussels, Human Physiology & Sports Medicine Department, Brussels, Belgium</aff><aff id="aff2"><label>2</label>Royal Military Academy of Brussels, VIPER Research Unit, Brussels, Belgium</aff><aff id="aff3"><label>3</label>Department of Automation, Biocybernetics, and Robotics, Jozef Stefan Institute, Ljubljana, Slovenia</aff><aff id="aff4"><label>4</label>Royal Military Academy Brussels, CISS, Brussels, Belgium</aff><aff id="aff5"><label>5</label>Sleep Laboratory & Unit for Chronobiology-Brugmann University Hospital Free University of Brussels (U.L.B./V.U.B), Brussels, Belgium</aff><aff id="aff6"><label>6</label>Department of Movement, Human and Health Sciences, University of Rome Foro Italico, Rome, Italy</aff><aff id="aff7"><label>7</label>JF Intensive Care Unit, Addenbrooke's Hospital, Cambridge, United Kingdom</aff><aff id="aff8"><label>8</label>Institut polaire français Paul-Emile Victor, Technopôle Brest-Iroise, Plouzané, France</aff><aff id="aff9"><label>9</label>Institute of Clinical Neurophysiology, University Clinical Centre, Ljubljana, Slovenia</aff><aff id="aff10"><label>10</label>Department of Environmental Physiology, Swedish Aerospace Physiology Centre, Royal Institute of Technology, Stockholm, Sweden</aff><aff id="aff11"><label>11</label>Experimental and Applied Psychology Department, Brussels, Belgium</aff><aff id="aff12"><label>12</label>School of Public Health, Tropical Medicine and Health Sciences, James Cook University, Townsville City, Queensland, Australia</aff></contrib-group><author-notes><fn fn-type="other" id="FN1"><label>*</label><p>co-first authors</p></fn><corresp id="cor1">Address correspondence to: Helio Fernandez Tellez, <addr-line>Vrije Universiteit Brussels, Human Physiology & Sports Medicine Department, Building L, Pleinlaan, 2, B-1050 Brussels, Belgium</addr-line><phone>+32 2 629 27 32</phone><fax>+32 2 629</fax><email>hefernan@vub.ac.be</email></corresp></author-notes><pub-date pub-type="epub"><day>1</day><month>4</month><year>2016</year></pub-date><volume>39</volume><issue>4</issue><fpage>773</fpage><lpage>783</lpage><history><date date-type="received"><month>5</month><year>2015</year></date><date date-type="rev-recd"><month>11</month><year>2015</year></date><date date-type="accepted"><month>11</month><year>2015</year></date></history><permissions><copyright-statement>© 2016 Associated Professional Sleep Societies, LLC.</copyright-statement><copyright-year>2016</copyright-year></permissions><abstract><sec><title>Study Objectives:</title><p>Exposure to hypoxia elevates chemosensitivity, which can lead to periodic breathing. Exercise impacts gas exchange, altering chemosensitivity; however, interactions between sleep, exercise and chronic hypoxic exposure have not been examined. This study investigated whether exercise exacerbates sleep-related periodic breathing in hypoxia.</p></sec><sec><title>Methods:</title><p>Two experimental phases. Short-Term Phase: a laboratory controlled, group-design study in which 16 active, healthy men (age: 25 ± 3 y, height: 1.79 ± 0.06 m, mass: 74 ± 8 kg) were confined to a normobaric hypoxic environment (FIO2 = 0.139 ± 0.003, 4,000 m) for 10 days, after random assignment to a sedentary (control, CON) or cycle-exercise group (EX). Long-Term Phase: conducted at the Concordia Antarctic Research Station (3,800 m equivalent at the Equator) where 14 men (age: 36 ± 9 y, height: 1.77 ± 0.09 m, mass: 75 ± 10 kg) lived for 12–14 months, continuously confined. Participants were stratified post hoc based on self-reported physical activity levels. We quantified apnea-hypopnea index (AHI) and physical activity variables.</p></sec><sec><title>Results:</title><p>Short-Term Phase: mean AHI scores were significantly elevated in the EX group compared to CON (Night1 = CON: 39 ± 51, EX: 91 ± 59; Night10 = CON: 32 ± 32, EX: 92 ± 48; P = 0.046). Long-Term Phase: AHI was correlated to mean exercise time (R<sup>2</sup> = 0.4857; P = 0.008) and the coefficient of variation in night oxyhemoglobin saturation (SpO2; R<sup>2</sup> = 0.3062; P = 0.049).</p></sec><sec><title>Conclusions:</title><p>Data indicate that exercise (physical activity) <italic>per se</italic> affects night SpO2 concentrations and AHI after a minimum of two bouts of moderate-intensity hypoxic exercise, while habitual physical activity in hypobaric hypoxic confinement affects breathing during sleep, up to 13+ months' duration</p></sec><sec><title>Citation:</title><p>Tellez HF, Morrison SA, Neyt X, Mairesse O, Piacentini MF, Macdonald-Nethercott E, Pangerc A, Dolenc-Groselj L, Eiken O, Pattyn N, Mekjavic IB, Meeusen R. Exercise during short-term and long-term continuous exposure to hypoxia exacerbates sleep-related periodic breathing. <italic>SLEEP</italic> 2016;39(4):773–783.</p></sec></abstract><kwd-group><kwd>Antarctica</kwd><kwd>sleep apnea</kwd><kwd>confinement</kwd><kwd>cycling</kwd><kwd>high altitude</kwd><kwd>oxygen saturation</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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