Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study
Identifieur interne : 000078 ( Pmc/Curation ); précédent : 000077; suivant : 000079Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study
Auteurs : A. Jakubowska [Pologne] ; D. Rozkrut [Pologne] ; A. Antoniou [Royaume-Uni] ; U. Hamann [Allemagne] ; R J Scott [Australie] ; L. Mcguffog [Royaume-Uni] ; S. Healy [Australie] ; O M Sinilnikova [France] ; G. Rennert [Israël] ; F. Lejbkowicz [Israël] ; A. Flugelman [Israël] ; I L Andrulis ; G. Glendon ; H. Ozcelik ; M. Thomassen [Danemark] ; M. Paligo [Italie] ; P. Aretini [Italie] ; J. Kantala [Suède] ; B. Aroer [Suède] ; A. Von Wachenfeldt [Suède] ; A. Liljegren [Suède] ; N. Loman [Suède] ; K. Herbst [Suède] ; U. Kristoffersson [Suède] ; R. Rosenquist [Suède] ; P. Karlsson [Suède] ; M. Stenmark-Askmalm [Suède] ; B. Melin [Suède] ; K L Nathanson [États-Unis] ; S M Domchek [États-Unis] ; T. Byrski [Pologne] ; T. Huzarski [Pologne] ; J. Gronwald [Pologne] ; J. Menkiszak [Pologne] ; C. Cybulski [Pologne] ; P. Serrano [Pologne] ; A. Osorio [Espagne] ; T R Cajal [Espagne] ; M. Tsitlaidou [Grèce] ; J. Benítez [Espagne] ; M. Gilbert [Allemagne] ; M. Rookus [Pays-Bas] ; C M Aalfs [Pays-Bas] ; I. Kluijt [Pays-Bas] ; J L Boessenkool-Pape [Pays-Bas] ; H E J. Meijers-Heijboer [Pays-Bas] ; J C Oosterwijk [Pays-Bas] ; C J Van Asperen [Pays-Bas] ; M J Blok [Pays-Bas] ; M R Nelen [Pays-Bas] ; A M W. Van Den Ouweland [Pays-Bas] ; C. Seynaeve [Pays-Bas] ; R B Van Der Luijt [Pays-Bas] ; P. Devilee [Pays-Bas] ; D F Easton [Royaume-Uni] ; S. Peock [Royaume-Uni] ; D. Frost [Royaume-Uni] ; R. Platte [Royaume-Uni] ; S D Ellis [Royaume-Uni] ; E. Fineberg [Royaume-Uni] ; D G Evans [Royaume-Uni] ; F. Lalloo [Royaume-Uni] ; R. Eeles [Royaume-Uni] ; C. Jacobs [Royaume-Uni] ; J. Adlard [Royaume-Uni] ; R. Davidson [Royaume-Uni] ; D. Eccles [Royaume-Uni] ; T. Cole [Royaume-Uni] ; J. Cook [Royaume-Uni] ; A. Godwin [États-Unis] ; B. Bove [États-Unis] ; D. Stoppa-Lyonnet [France] ; V. Caux-Moncoutier [France] ; M. Belotti [France] ; C. Tirapo [France] ; S. Mazoyer [France] ; L. Barjhoux [France] ; N. Boutry-Kryza [France] ; P. Pujol [France] ; I. Coupier [France] ; J-P Peyrat [France] ; P. Vennin [France] ; D. Muller [France] ; J-P Fricker [France] ; L. Venat-Bouvet [France] ; O Th Johannsson [Islande] ; C. Isaacs [États-Unis] ; R. Schmutzler [Allemagne] ; B. Wappenschmidt [Allemagne] ; A. Meindl [Allemagne] ; N. Arnold [Allemagne] ; R. Varon-Mateeva [Allemagne] ; D. Niederacher [Allemagne] ; C. Sutter [Allemagne] ; H. Deissler [Allemagne] ; S. Preisler-Adams [Allemagne] ; J. Simard [Canada] ; P. Soucy [Canada] ; F. Durocher [Canada] ; G. Chenevix-Trench [Australie] ; J. Beesley [Australie] ; X. Chen [Australie] ; T. Rebbeck [États-Unis] ; F. Couch [États-Unis] ; X. Wang [États-Unis] ; N. Lindor [États-Unis] ; Z. Fredericksen [États-Unis] ; V S Pankratz [États-Unis] ; P. Peterlongo [Italie] ; B. Bonanni [Italie] ; S. Fortuzzi [Italie] ; B. Peissel [Italie] ; C. Szabo [États-Unis] ; P L Mai [États-Unis] ; J T Loud [États-Unis] ; J. Lubinski [Pologne]Source :
- British Journal of Cancer [ 0007-0920 ] ; 2012.
Abstract
The variable penetrance of breast cancer in
To evaluate the potential role of genetic variants within
There was no evidence of association between the
The
Url:
DOI: 10.1038/bjc.2012.160
PubMed: 22669161
PubMed Central: 3388557
Links toward previous steps (curation, corpus...)
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I L Andrulis<affiliation><nlm:aff id="aff11"><institution>Department of Molecular Genetics, Ontario Cancer Genetics Network, Cancer Care Ontario and Samuel Lunenfeld Research Institute, Mount Sinai Hospital</institution>
, Toronto,<country>Ontario</country>
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<wicri:noCountry code="nlm country">Ontario</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="aff12"><institution>Samuel Lunenfeld Research Institute, Mount Sinai Hospital</institution>
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<affiliation><nlm:aff id="aff12"><institution>Samuel Lunenfeld Research Institute, Mount Sinai Hospital</institution>
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<affiliation><nlm:aff id="aff11"><institution>Department of Molecular Genetics, Ontario Cancer Genetics Network, Cancer Care Ontario and Samuel Lunenfeld Research Institute, Mount Sinai Hospital</institution>
, Toronto,<country>Ontario</country>
</nlm:aff>
<wicri:noCountry code="nlm country">Ontario</wicri:noCountry>
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<affiliation><nlm:aff id="aff12"><institution>Samuel Lunenfeld Research Institute, Mount Sinai Hospital</institution>
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Le document en format XML
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<country xml:lang="fr">Royaume-Uni</country>
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</nlm:aff>
<country xml:lang="fr">Allemagne</country>
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<author><name sortKey="Scott, R J" sort="Scott, R J" uniqKey="Scott R" first="R J" last="Scott">R J Scott</name>
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</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Mcguffog, L" sort="Mcguffog, L" uniqKey="Mcguffog L" first="L" last="Mcguffog">L. Mcguffog</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Healy, S" sort="Healy, S" uniqKey="Healy S" first="S" last="Healy">S. Healy</name>
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<country xml:lang="fr">Australie</country>
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<author><name sortKey="Sinilnikova, O M" sort="Sinilnikova, O M" uniqKey="Sinilnikova O" first="O M" last="Sinilnikova">O M Sinilnikova</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:aff id="aff9"><institution>INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon</institution>
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</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Rennert, G" sort="Rennert, G" uniqKey="Rennert G" first="G" last="Rennert">G. Rennert</name>
<affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Department of Community Medicine and Epidemiology and Clalit National Cancer Control Center, Carmel Medical Center and B Rappaport Faculty of Medicine, Technion</institution>
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</nlm:aff>
<country xml:lang="fr">Israël</country>
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<author><name sortKey="Lejbkowicz, F" sort="Lejbkowicz, F" uniqKey="Lejbkowicz F" first="F" last="Lejbkowicz">F. Lejbkowicz</name>
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</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Flugelman, A" sort="Flugelman, A" uniqKey="Flugelman A" first="A" last="Flugelman">A. Flugelman</name>
<affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Department of Community Medicine and Epidemiology and Clalit National Cancer Control Center, Carmel Medical Center and B Rappaport Faculty of Medicine, Technion</institution>
, Haifa,<country>Israel</country>
</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Andrulis, I L" sort="Andrulis, I L" uniqKey="Andrulis I" first="I L" last="Andrulis">I L Andrulis</name>
<affiliation><nlm:aff id="aff11"><institution>Department of Molecular Genetics, Ontario Cancer Genetics Network, Cancer Care Ontario and Samuel Lunenfeld Research Institute, Mount Sinai Hospital</institution>
, Toronto,<country>Ontario</country>
</nlm:aff>
<wicri:noCountry code="nlm country">Ontario</wicri:noCountry>
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<affiliation><nlm:aff id="aff12"><institution>Samuel Lunenfeld Research Institute, Mount Sinai Hospital</institution>
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</nlm:aff>
<wicri:noCountry code="nlm country">Ontario</wicri:noCountry>
</affiliation>
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<author><name sortKey="Glendon, G" sort="Glendon, G" uniqKey="Glendon G" first="G" last="Glendon">G. Glendon</name>
<affiliation><nlm:aff id="aff11"><institution>Department of Molecular Genetics, Ontario Cancer Genetics Network, Cancer Care Ontario and Samuel Lunenfeld Research Institute, Mount Sinai Hospital</institution>
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<wicri:noCountry code="nlm country">Ontario</wicri:noCountry>
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<affiliation><nlm:aff id="aff12"><institution>Samuel Lunenfeld Research Institute, Mount Sinai Hospital</institution>
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<wicri:noCountry code="nlm country">Ontario</wicri:noCountry>
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<author><name sortKey="Thomassen, M" sort="Thomassen, M" uniqKey="Thomassen M" first="M" last="Thomassen">M. Thomassen</name>
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</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Paligo, M" sort="Paligo, M" uniqKey="Paligo M" first="M" last="Paligo">M. Paligo</name>
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</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Aretini, P" sort="Aretini, P" uniqKey="Aretini P" first="P" last="Aretini">P. Aretini</name>
<affiliation wicri:level="1"><nlm:aff id="aff15"><institution>Section of Genetic Oncology, University Hospital of Pisa</institution>
, Pisa,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Kantala, J" sort="Kantala, J" uniqKey="Kantala J" first="J" last="Kantala">J. Kantala</name>
<affiliation wicri:level="1"><nlm:aff id="aff16"><institution>Department of Clinical Genetics, Karolinska University Hospital</institution>
, Stockholm,<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Aroer, B" sort="Aroer, B" uniqKey="Aroer B" first="B" last="Aroer">B. Aroer</name>
<affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Department of Oncology, Karolinska University Hospital</institution>
, Stockholm,<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author><name sortKey="Von Wachenfeldt, A" sort="Von Wachenfeldt, A" uniqKey="Von Wachenfeldt A" first="A" last="Von Wachenfeldt">A. Von Wachenfeldt</name>
<affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Department of Oncology, Karolinska University Hospital</institution>
, Stockholm,<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author><name sortKey="Liljegren, A" sort="Liljegren, A" uniqKey="Liljegren A" first="A" last="Liljegren">A. Liljegren</name>
<affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Department of Oncology, Karolinska University Hospital</institution>
, Stockholm,<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author><name sortKey="Loman, N" sort="Loman, N" uniqKey="Loman N" first="N" last="Loman">N. Loman</name>
<affiliation wicri:level="1"><nlm:aff id="aff18"><institution>Department of Oncology, Lund University Hospital</institution>
, Lund,<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author><name sortKey="Herbst, K" sort="Herbst, K" uniqKey="Herbst K" first="K" last="Herbst">K. Herbst</name>
<affiliation wicri:level="1"><nlm:aff id="aff18"><institution>Department of Oncology, Lund University Hospital</institution>
, Lund,<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author><name sortKey="Kristoffersson, U" sort="Kristoffersson, U" uniqKey="Kristoffersson U" first="U" last="Kristoffersson">U. Kristoffersson</name>
<affiliation wicri:level="1"><nlm:aff id="aff19"><institution>Department of Clinical Genetics, Lund University Hospital</institution>
, Lund,<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author><name sortKey="Rosenquist, R" sort="Rosenquist, R" uniqKey="Rosenquist R" first="R" last="Rosenquist">R. Rosenquist</name>
<affiliation wicri:level="1"><nlm:aff id="aff20"><institution>Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University</institution>
, Uppsala,<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Karlsson, P" sort="Karlsson, P" uniqKey="Karlsson P" first="P" last="Karlsson">P. Karlsson</name>
<affiliation wicri:level="1"><nlm:aff id="aff21"><institution>Department of Oncology, Sahlgrenska University Hospital</institution>
, Gothenburg,<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stenmark Askmalm, M" sort="Stenmark Askmalm, M" uniqKey="Stenmark Askmalm M" first="M" last="Stenmark-Askmalm">M. Stenmark-Askmalm</name>
<affiliation wicri:level="1"><nlm:aff id="aff22"><institution>Department of Oncology, University Hospital</institution>
, Linköping<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Melin, B" sort="Melin, B" uniqKey="Melin B" first="B" last="Melin">B. Melin</name>
<affiliation wicri:level="1"><nlm:aff id="aff23"><institution>Department of Radiation Sciences, Oncology, Umeå University</institution>
, Umeå,<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nathanson, K L" sort="Nathanson, K L" uniqKey="Nathanson K" first="K L" last="Nathanson">K L Nathanson</name>
<affiliation wicri:level="1"><nlm:aff id="aff24"><institution>Department of Medicine and Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania</institution>
, Philadelphia, PN,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author><name sortKey="Domchek, S M" sort="Domchek, S M" uniqKey="Domchek S" first="S M" last="Domchek">S M Domchek</name>
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</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Byrski, T" sort="Byrski, T" uniqKey="Byrski T" first="T" last="Byrski">T. Byrski</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>
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</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Huzarski, T" sort="Huzarski, T" uniqKey="Huzarski T" first="T" last="Huzarski">T. Huzarski</name>
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</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author><name sortKey="Gronwald, J" sort="Gronwald, J" uniqKey="Gronwald J" first="J" last="Gronwald">J. Gronwald</name>
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, Szczecin,<country>Poland</country>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Menkiszak, J" sort="Menkiszak, J" uniqKey="Menkiszak J" first="J" last="Menkiszak">J. Menkiszak</name>
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</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Cybulski, C" sort="Cybulski, C" uniqKey="Cybulski C" first="C" last="Cybulski">C. Cybulski</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>
, Szczecin,<country>Poland</country>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Serrano, P" sort="Serrano, P" uniqKey="Serrano P" first="P" last="Serrano">P. Serrano</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>
, Szczecin,<country>Poland</country>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Osorio, A" sort="Osorio, A" uniqKey="Osorio A" first="A" last="Osorio">A. Osorio</name>
<affiliation wicri:level="1"><nlm:aff id="aff26"><institution>Human Genetics Group and Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre</institution>
, Madrid,<country>Spain</country>
(and Spanish Network on Rare Diseases (CIBERER))</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cajal, T R" sort="Cajal, T R" uniqKey="Cajal T" first="T R" last="Cajal">T R Cajal</name>
<affiliation wicri:level="1"><nlm:aff id="aff27"><institution>Oncology Service, Hospital de la Santa Creu i Sant Pau</institution>
, Barcelona,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tsitlaidou, M" sort="Tsitlaidou, M" uniqKey="Tsitlaidou M" first="M" last="Tsitlaidou">M. Tsitlaidou</name>
<affiliation wicri:level="1"><nlm:aff id="aff28"><institution>Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research ‘Demokritos', Aghia Paraskevi Attikis</institution>
, Athens 15310,<country>Greece</country>
</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Benitez, J" sort="Benitez, J" uniqKey="Benitez J" first="J" last="Benítez">J. Benítez</name>
<affiliation wicri:level="1"><nlm:aff id="aff26"><institution>Human Genetics Group and Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre</institution>
, Madrid,<country>Spain</country>
(and Spanish Network on Rare Diseases (CIBERER))</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gilbert, M" sort="Gilbert, M" uniqKey="Gilbert M" first="M" last="Gilbert">M. Gilbert</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Functional Genome Analysis, Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ)</institution>
, Heidelberg,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rookus, M" sort="Rookus, M" uniqKey="Rookus M" first="M" last="Rookus">M. Rookus</name>
<affiliation wicri:level="1"><nlm:aff id="aff29"><institution>Department of Epidemiology, Netherlands Cancer Institute</institution>
, Amsterdam,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Aalfs, C M" sort="Aalfs, C M" uniqKey="Aalfs C" first="C M" last="Aalfs">C M Aalfs</name>
<affiliation wicri:level="1"><nlm:aff id="aff30"><institution>Department of Clinical Genetics, Academic Medical Center</institution>
, Amsterdam,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kluijt, I" sort="Kluijt, I" uniqKey="Kluijt I" first="I" last="Kluijt">I. Kluijt</name>
<affiliation wicri:level="1"><nlm:aff id="aff31"><institution>Department of Family Cancer Clinic, Netherlands Cancer Institute</institution>
, Amsterdam,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Boessenkool Pape, J L" sort="Boessenkool Pape, J L" uniqKey="Boessenkool Pape J" first="J L" last="Boessenkool-Pape">J L Boessenkool-Pape</name>
<affiliation wicri:level="1"><nlm:aff id="aff29"><institution>Department of Epidemiology, Netherlands Cancer Institute</institution>
, Amsterdam,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Meijers Heijboer, H E J" sort="Meijers Heijboer, H E J" uniqKey="Meijers Heijboer H" first="H E J" last="Meijers-Heijboer">H E J. Meijers-Heijboer</name>
<affiliation wicri:level="1"><nlm:aff id="aff32"><institution>Department of Clinical Genetics, VU Medical Center</institution>
, Amsterdam,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Oosterwijk, J C" sort="Oosterwijk, J C" uniqKey="Oosterwijk J" first="J C" last="Oosterwijk">J C Oosterwijk</name>
<affiliation wicri:level="1"><nlm:aff id="aff33"><institution>Department of Genetics, University Medical Center, Groningen University</institution>
, Groningen,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Asperen, C J" sort="Van Asperen, C J" uniqKey="Van Asperen C" first="C J" last="Van Asperen">C J Van Asperen</name>
<affiliation wicri:level="1"><nlm:aff id="aff34"><institution>Department of Clinical Genetics Leiden University Medical Center Leiden</institution>
, Leiden,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Blok, M J" sort="Blok, M J" uniqKey="Blok M" first="M J" last="Blok">M J Blok</name>
<affiliation wicri:level="1"><nlm:aff id="aff35"><institution>Department of Clinical Genetics, University Hospital Maastricht</institution>
, Maastricht,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nelen, M R" sort="Nelen, M R" uniqKey="Nelen M" first="M R" last="Nelen">M R Nelen</name>
<affiliation wicri:level="1"><nlm:aff id="aff36"><institution>Department of Human Genetics 849, Radboud University Nijmegen Medical Centre</institution>
, P.O. BOX 9101, HB Nijmegen, Nijmegen 6500,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Den Ouweland, A M W" sort="Van Den Ouweland, A M W" uniqKey="Van Den Ouweland A" first="A M W" last="Van Den Ouweland">A M W. Van Den Ouweland</name>
<affiliation wicri:level="1"><nlm:aff id="aff37"><institution>Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center</institution>
, Rotterdam,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Seynaeve, C" sort="Seynaeve, C" uniqKey="Seynaeve C" first="C" last="Seynaeve">C. Seynaeve</name>
<affiliation wicri:level="1"><nlm:aff id="aff38"><institution>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center</institution>
, Rotterdam,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Der Luijt, R B" sort="Van Der Luijt, R B" uniqKey="Van Der Luijt R" first="R B" last="Van Der Luijt">R B Van Der Luijt</name>
<affiliation wicri:level="1"><nlm:aff id="aff39"><institution>Department of Medical Genetics, University Medical Center Utrecht</institution>
, Utrecht,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Devilee, P" sort="Devilee, P" uniqKey="Devilee P" first="P" last="Devilee">P. Devilee</name>
<affiliation wicri:level="1"><nlm:aff id="aff40"><institution>Department of Human Genetics & Department of Pathology, Leiden University Medical Center</institution>
, Leiden,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Easton, D F" sort="Easton, D F" uniqKey="Easton D" first="D F" last="Easton">D F Easton</name>
<affiliation wicri:level="1"><nlm:aff id="aff41"><institution>Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>
, Cambridge,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peock, S" sort="Peock, S" uniqKey="Peock S" first="S" last="Peock">S. Peock</name>
<affiliation wicri:level="1"><nlm:aff id="aff41"><institution>Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>
, Cambridge,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Frost, D" sort="Frost, D" uniqKey="Frost D" first="D" last="Frost">D. Frost</name>
<affiliation wicri:level="1"><nlm:aff id="aff41"><institution>Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>
, Cambridge,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Platte, R" sort="Platte, R" uniqKey="Platte R" first="R" last="Platte">R. Platte</name>
<affiliation wicri:level="1"><nlm:aff id="aff41"><institution>Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>
, Cambridge,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ellis, S D" sort="Ellis, S D" uniqKey="Ellis S" first="S D" last="Ellis">S D Ellis</name>
<affiliation wicri:level="1"><nlm:aff id="aff41"><institution>Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>
, Cambridge,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fineberg, E" sort="Fineberg, E" uniqKey="Fineberg E" first="E" last="Fineberg">E. Fineberg</name>
<affiliation wicri:level="1"><nlm:aff id="aff41"><institution>Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>
, Cambridge,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Evans, D G" sort="Evans, D G" uniqKey="Evans D" first="D G" last="Evans">D G Evans</name>
<affiliation wicri:level="1"><nlm:aff id="aff42"><institution>Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust</institution>
, Manchester,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lalloo, F" sort="Lalloo, F" uniqKey="Lalloo F" first="F" last="Lalloo">F. Lalloo</name>
<affiliation wicri:level="1"><nlm:aff id="aff42"><institution>Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust</institution>
, Manchester,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eeles, R" sort="Eeles, R" uniqKey="Eeles R" first="R" last="Eeles">R. Eeles</name>
<affiliation wicri:level="1"><nlm:aff id="aff43"><institution>Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust</institution>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jacobs, C" sort="Jacobs, C" uniqKey="Jacobs C" first="C" last="Jacobs">C. Jacobs</name>
<affiliation wicri:level="1"><nlm:aff id="aff44"><institution>Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust</institution>
, London,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Adlard, J" sort="Adlard, J" uniqKey="Adlard J" first="J" last="Adlard">J. Adlard</name>
<affiliation wicri:level="1"><nlm:aff id="aff45"><institution>Yorkshire Regional Genetics Service</institution>
, Leeds,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Davidson, R" sort="Davidson, R" uniqKey="Davidson R" first="R" last="Davidson">R. Davidson</name>
<affiliation wicri:level="1"><nlm:aff id="aff46"><institution>Ferguson-Smith Centre for Clinical Genetics, Yorkhill Hospitals</institution>
, Glasgow,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eccles, D" sort="Eccles, D" uniqKey="Eccles D" first="D" last="Eccles">D. Eccles</name>
<affiliation wicri:level="1"><nlm:aff id="aff47"><institution>University of Southampton Faculty of Medicine, Southampton University Hospitals NHS Trust</institution>
, Southampton,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cole, T" sort="Cole, T" uniqKey="Cole T" first="T" last="Cole">T. Cole</name>
<affiliation wicri:level="1"><nlm:aff id="aff48"><institution>West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust</institution>
, Edgbaston, Birmingham,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cook, J" sort="Cook, J" uniqKey="Cook J" first="J" last="Cook">J. Cook</name>
<affiliation wicri:level="1"><nlm:aff id="aff49"><institution>Sheffield Clinical Genetics Service, Sheffield Children's Hospital</institution>
, Sheffield,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Godwin, A" sort="Godwin, A" uniqKey="Godwin A" first="A" last="Godwin">A. Godwin</name>
<affiliation wicri:level="1"><nlm:aff id="aff50"><institution>Department of Pathology and Laboratory Medicine, the University of Kansas Medical Center</institution>
, Kansas City, KS,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bove, B" sort="Bove, B" uniqKey="Bove B" first="B" last="Bove">B. Bove</name>
<affiliation wicri:level="1"><nlm:aff id="aff51"><institution>Clinical Molecular Genetics Laboratory, Fox Chase Cancer Center</institution>
, Philadelphia, PA,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stoppa Lyonnet, D" sort="Stoppa Lyonnet, D" uniqKey="Stoppa Lyonnet D" first="D" last="Stoppa-Lyonnet">D. Stoppa-Lyonnet</name>
<affiliation wicri:level="1"><nlm:aff id="aff53"><institution>Service de Génétique Oncologique, Département de Biologie des Tumeurs, Institut Curie</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff54"><institution>Unité INSERM U830, Institut Curie</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff55"><institution>Université Paris Descartes, Faculté de Médecine</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Caux Moncoutier, V" sort="Caux Moncoutier, V" uniqKey="Caux Moncoutier V" first="V" last="Caux-Moncoutier">V. Caux-Moncoutier</name>
<affiliation wicri:level="1"><nlm:aff id="aff53"><institution>Service de Génétique Oncologique, Département de Biologie des Tumeurs, Institut Curie</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Belotti, M" sort="Belotti, M" uniqKey="Belotti M" first="M" last="Belotti">M. Belotti</name>
<affiliation wicri:level="1"><nlm:aff id="aff53"><institution>Service de Génétique Oncologique, Département de Biologie des Tumeurs, Institut Curie</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tirapo, C" sort="Tirapo, C" uniqKey="Tirapo C" first="C" last="Tirapo">C. Tirapo</name>
<affiliation wicri:level="1"><nlm:aff id="aff53"><institution>Service de Génétique Oncologique, Département de Biologie des Tumeurs, Institut Curie</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mazoyer, S" sort="Mazoyer, S" uniqKey="Mazoyer S" first="S" last="Mazoyer">S. Mazoyer</name>
<affiliation wicri:level="1"><nlm:aff id="aff9"><institution>INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon</institution>
, Lyon,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Barjhoux, L" sort="Barjhoux, L" uniqKey="Barjhoux L" first="L" last="Barjhoux">L. Barjhoux</name>
<affiliation wicri:level="1"><nlm:aff id="aff9"><institution>INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon</institution>
, Lyon,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Boutry Kryza, N" sort="Boutry Kryza, N" uniqKey="Boutry Kryza N" first="N" last="Boutry-Kryza">N. Boutry-Kryza</name>
<affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon, Centre Hospitalier Universitaire de Lyon/Centre Léon Bérard</institution>
, Lyon,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pujol, P" sort="Pujol, P" uniqKey="Pujol P" first="P" last="Pujol">P. Pujol</name>
<affiliation wicri:level="1"><nlm:aff id="aff56"><institution>Unité d'Oncogénétique, CHU Arnaud de Villeneuve</institution>
, Montpellier,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff57"><institution>INSERM 896, CRCM Val d'Aurelle</institution>
, Montpellier,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Coupier, I" sort="Coupier, I" uniqKey="Coupier I" first="I" last="Coupier">I. Coupier</name>
<affiliation wicri:level="1"><nlm:aff id="aff56"><institution>Unité d'Oncogénétique, CHU Arnaud de Villeneuve</institution>
, Montpellier,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff58"><institution>Unité d'Oncogénétique, CRLCC Val d'Aurelle</institution>
, Montpellier,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peyrat, J P" sort="Peyrat, J P" uniqKey="Peyrat J" first="J-P" last="Peyrat">J-P Peyrat</name>
<affiliation wicri:level="1"><nlm:aff id="aff59"><institution>Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret</institution>
, Lille,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vennin, P" sort="Vennin, P" uniqKey="Vennin P" first="P" last="Vennin">P. Vennin</name>
<affiliation wicri:level="1"><nlm:aff id="aff60"><institution>Consultation d'Oncogénétique, Centre Oscar Lambret</institution>
, Lille,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Muller, D" sort="Muller, D" uniqKey="Muller D" first="D" last="Muller">D. Muller</name>
<affiliation wicri:level="1"><nlm:aff id="aff61"><institution>Unité d'Oncogénétique, CLCC Paul Strauss</institution>
, Strasbourg,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fricker, J P" sort="Fricker, J P" uniqKey="Fricker J" first="J-P" last="Fricker">J-P Fricker</name>
<affiliation wicri:level="1"><nlm:aff id="aff61"><institution>Unité d'Oncogénétique, CLCC Paul Strauss</institution>
, Strasbourg,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Venat Bouvet, L" sort="Venat Bouvet, L" uniqKey="Venat Bouvet L" first="L" last="Venat-Bouvet">L. Venat-Bouvet</name>
<affiliation wicri:level="1"><nlm:aff id="aff62"><institution>Department of Medical Oncology, Centre Hospitalier Universitaire Dupuytren</institution>
, Limoges,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Johannsson, O Th" sort="Johannsson, O Th" uniqKey="Johannsson O" first="O Th" last="Johannsson">O Th Johannsson</name>
<affiliation wicri:level="1"><nlm:aff id="aff63"><institution>Department of Oncology, Landspitali University Hospital</institution>
, Reykjavik,<country>Iceland</country>
</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff64"><institution>Faculity of Medicine, University of Iceland</institution>
, Reykjavik,<country>Iceland</country>
</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Isaacs, C" sort="Isaacs, C" uniqKey="Isaacs C" first="C" last="Isaacs">C. Isaacs</name>
<affiliation wicri:level="1"><nlm:aff id="aff65"><institution>Department of Medicine and Oncology, Georgetown University</institution>
, Washington, DC,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schmutzler, R" sort="Schmutzler, R" uniqKey="Schmutzler R" first="R" last="Schmutzler">R. Schmutzler</name>
<affiliation wicri:level="1"><nlm:aff id="aff66"><institution>Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), University hospital of Cologne</institution>
, Cologne,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wappenschmidt, B" sort="Wappenschmidt, B" uniqKey="Wappenschmidt B" first="B" last="Wappenschmidt">B. Wappenschmidt</name>
<affiliation wicri:level="1"><nlm:aff id="aff66"><institution>Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), University hospital of Cologne</institution>
, Cologne,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Meindl, A" sort="Meindl, A" uniqKey="Meindl A" first="A" last="Meindl">A. Meindl</name>
<affiliation wicri:level="1"><nlm:aff id="aff67"><institution>Department of Gynaecology and Obstetrics, Ludwig-Maximillians University Munich</institution>
, Munich,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Arnold, N" sort="Arnold, N" uniqKey="Arnold N" first="N" last="Arnold">N. Arnold</name>
<affiliation wicri:level="1"><nlm:aff id="aff68"><institution>Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University</institution>
, Kiel,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Varon Mateeva, R" sort="Varon Mateeva, R" uniqKey="Varon Mateeva R" first="R" last="Varon-Mateeva">R. Varon-Mateeva</name>
<affiliation wicri:level="1"><nlm:aff id="aff69"><institution>Institute of Human Genetics, Campus Virchov Klinikum</institution>
, Charite Berlin,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Niederacher, D" sort="Niederacher, D" uniqKey="Niederacher D" first="D" last="Niederacher">D. Niederacher</name>
<affiliation wicri:level="1"><nlm:aff id="aff70"><institution>Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University</institution>
, Düsseldorf,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sutter, C" sort="Sutter, C" uniqKey="Sutter C" first="C" last="Sutter">C. Sutter</name>
<affiliation wicri:level="1"><nlm:aff id="aff71"><institution>Institute of Human Genetics, Department of Human Genetics, University Hospital Heidelberg</institution>
, Heidelberg,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Deissler, H" sort="Deissler, H" uniqKey="Deissler H" first="H" last="Deissler">H. Deissler</name>
<affiliation wicri:level="1"><nlm:aff id="aff72"><institution>Department of Gynaecology and Obstetrics, University Hospital</institution>
, Ulm,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Preisler Adams, S" sort="Preisler Adams, S" uniqKey="Preisler Adams S" first="S" last="Preisler-Adams">S. Preisler-Adams</name>
<affiliation wicri:level="1"><nlm:aff id="aff73"><institution>Institute of Human Genetics, University of Münster</institution>
, Münster,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Simard, J" sort="Simard, J" uniqKey="Simard J" first="J" last="Simard">J. Simard</name>
<affiliation wicri:level="1"><nlm:aff id="aff74"><institution>Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University</institution>
, Quebec,<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Soucy, P" sort="Soucy, P" uniqKey="Soucy P" first="P" last="Soucy">P. Soucy</name>
<affiliation wicri:level="1"><nlm:aff id="aff74"><institution>Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University</institution>
, Quebec,<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Durocher, F" sort="Durocher, F" uniqKey="Durocher F" first="F" last="Durocher">F. Durocher</name>
<affiliation wicri:level="1"><nlm:aff id="aff74"><institution>Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University</institution>
, Quebec,<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chenevix Trench, G" sort="Chenevix Trench, G" uniqKey="Chenevix Trench G" first="G" last="Chenevix-Trench">G. Chenevix-Trench</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Genetics and Population Health Division, Queensland Institute of Medical Research</institution>
, Brisbane,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Beesley, J" sort="Beesley, J" uniqKey="Beesley J" first="J" last="Beesley">J. Beesley</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Genetics and Population Health Division, Queensland Institute of Medical Research</institution>
, Brisbane,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chen, X" sort="Chen, X" uniqKey="Chen X" first="X" last="Chen">X. Chen</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Genetics and Population Health Division, Queensland Institute of Medical Research</institution>
, Brisbane,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rebbeck, T" sort="Rebbeck, T" uniqKey="Rebbeck T" first="T" last="Rebbeck">T. Rebbeck</name>
<affiliation wicri:level="1"><nlm:aff id="aff76"><institution>Department of Biostatistics and Epidemiology, Perelman School of Medicine and Abramson Cancer Center, University of Pennsylvania</institution>
, Philadelphia, PA,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Couch, F" sort="Couch, F" uniqKey="Couch F" first="F" last="Couch">F. Couch</name>
<affiliation wicri:level="1"><nlm:aff id="aff77"><institution>Department of Laboratory Medicine and Pathology, Mayo Clinic</institution>
, Rochester, MN,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff78"><institution>Department of Health Sciences Research, Mayo Clinic</institution>
, Rochester, MN,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wang, X" sort="Wang, X" uniqKey="Wang X" first="X" last="Wang">X. Wang</name>
<affiliation wicri:level="1"><nlm:aff id="aff77"><institution>Department of Laboratory Medicine and Pathology, Mayo Clinic</institution>
, Rochester, MN,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lindor, N" sort="Lindor, N" uniqKey="Lindor N" first="N" last="Lindor">N. Lindor</name>
<affiliation wicri:level="1"><nlm:aff id="aff79"><institution>Department of Medical Genetics, Mayo Clinic</institution>
, Rochester, MN,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fredericksen, Z" sort="Fredericksen, Z" uniqKey="Fredericksen Z" first="Z" last="Fredericksen">Z. Fredericksen</name>
<affiliation wicri:level="1"><nlm:aff id="aff78"><institution>Department of Health Sciences Research, Mayo Clinic</institution>
, Rochester, MN,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pankratz, V S" sort="Pankratz, V S" uniqKey="Pankratz V" first="V S" last="Pankratz">V S Pankratz</name>
<affiliation wicri:level="1"><nlm:aff id="aff78"><institution>Department of Health Sciences Research, Mayo Clinic</institution>
, Rochester, MN,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peterlongo, P" sort="Peterlongo, P" uniqKey="Peterlongo P" first="P" last="Peterlongo">P. Peterlongo</name>
<affiliation wicri:level="1"><nlm:aff id="aff80"><institution>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predicted Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT)</institution>
, Milan,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff81"><institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare</institution>
, Milan,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bonanni, B" sort="Bonanni, B" uniqKey="Bonanni B" first="B" last="Bonanni">B. Bonanni</name>
<affiliation wicri:level="1"><nlm:aff id="aff82"><institution>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia</institution>
, Milan,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fortuzzi, S" sort="Fortuzzi, S" uniqKey="Fortuzzi S" first="S" last="Fortuzzi">S. Fortuzzi</name>
<affiliation wicri:level="1"><nlm:aff id="aff83"><institution>82-IFOM, Fondazione Istituto FIRC di Oncologia Molecolare and 84-Cogentech Cancer Genetic Test Laboratory</institution>
, Milan,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peissel, B" sort="Peissel, B" uniqKey="Peissel B" first="B" last="Peissel">B. Peissel</name>
<affiliation wicri:level="1"><nlm:aff id="aff84"><institution>Unit of Medical Genetics, Department of Preventive and Preventive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT)</institution>
, Milan,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Szabo, C" sort="Szabo, C" uniqKey="Szabo C" first="C" last="Szabo">C. Szabo</name>
<affiliation wicri:level="1"><nlm:aff id="aff85"><institution>Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine</institution>
, Rochester, MN,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mai, P L" sort="Mai, P L" uniqKey="Mai P" first="P L" last="Mai">P L Mai</name>
<affiliation wicri:level="1"><nlm:aff id="aff86"><institution>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services</institution>
, 6120 Executive Boulelvard, Rockville, MD 20852,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Loud, J T" sort="Loud, J T" uniqKey="Loud J" first="J T" last="Loud">J T Loud</name>
<affiliation wicri:level="1"><nlm:aff id="aff86"><institution>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services</institution>
, 6120 Executive Boulelvard, Rockville, MD 20852,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lubinski, J" sort="Lubinski, J" uniqKey="Lubinski J" first="J" last="Lubinski">J. Lubinski</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>
, Szczecin,<country>Poland</country>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">22669161</idno>
<idno type="pmc">3388557</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388557</idno>
<idno type="RBID">PMC:3388557</idno>
<idno type="doi">10.1038/bjc.2012.160</idno>
<date when="2012">2012</date>
<idno type="wicri:Area/Pmc/Corpus">000078</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000078</idno>
<idno type="wicri:Area/Pmc/Curation">000078</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000078</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study</title>
<author><name sortKey="Jakubowska, A" sort="Jakubowska, A" uniqKey="Jakubowska A" first="A" last="Jakubowska">A. Jakubowska</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>
, Szczecin,<country>Poland</country>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rozkrut, D" sort="Rozkrut, D" uniqKey="Rozkrut D" first="D" last="Rozkrut">D. Rozkrut</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Statistics and Econometrics, School of Economics and Management, University of Szczecin</institution>
, Szczecin,<country>Poland</country>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Antoniou, A" sort="Antoniou, A" uniqKey="Antoniou A" first="A" last="Antoniou">A. Antoniou</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory</institution>
, Cambridge,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hamann, U" sort="Hamann, U" uniqKey="Hamann U" first="U" last="Hamann">U. Hamann</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Functional Genome Analysis, Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ)</institution>
, Heidelberg,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Scott, R J" sort="Scott, R J" uniqKey="Scott R" first="R J" last="Scott">R J Scott</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Department of Medical Genetics, Faculty of Health, University of Newcastle, and the Hunter Medical Research Institute</institution>
, NSW,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mcguffog, L" sort="Mcguffog, L" uniqKey="Mcguffog L" first="L" last="Mcguffog">L. Mcguffog</name>
<affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge</institution>
, Cambridge,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Healy, S" sort="Healy, S" uniqKey="Healy S" first="S" last="Healy">S. Healy</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Genetics and Population Health Division, Queensland Institute of Medical Research</institution>
, Brisbane,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sinilnikova, O M" sort="Sinilnikova, O M" uniqKey="Sinilnikova O" first="O M" last="Sinilnikova">O M Sinilnikova</name>
<affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon, Centre Hospitalier Universitaire de Lyon/Centre Léon Bérard</institution>
, Lyon,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff9"><institution>INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon</institution>
, Lyon,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rennert, G" sort="Rennert, G" uniqKey="Rennert G" first="G" last="Rennert">G. Rennert</name>
<affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Department of Community Medicine and Epidemiology and Clalit National Cancer Control Center, Carmel Medical Center and B Rappaport Faculty of Medicine, Technion</institution>
, Haifa,<country>Israel</country>
</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lejbkowicz, F" sort="Lejbkowicz, F" uniqKey="Lejbkowicz F" first="F" last="Lejbkowicz">F. Lejbkowicz</name>
<affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Department of Community Medicine and Epidemiology and Clalit National Cancer Control Center, Carmel Medical Center and B Rappaport Faculty of Medicine, Technion</institution>
, Haifa,<country>Israel</country>
</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Flugelman, A" sort="Flugelman, A" uniqKey="Flugelman A" first="A" last="Flugelman">A. Flugelman</name>
<affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Department of Community Medicine and Epidemiology and Clalit National Cancer Control Center, Carmel Medical Center and B Rappaport Faculty of Medicine, Technion</institution>
, Haifa,<country>Israel</country>
</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Andrulis, I L" sort="Andrulis, I L" uniqKey="Andrulis I" first="I L" last="Andrulis">I L Andrulis</name>
<affiliation><nlm:aff id="aff11"><institution>Department of Molecular Genetics, Ontario Cancer Genetics Network, Cancer Care Ontario and Samuel Lunenfeld Research Institute, Mount Sinai Hospital</institution>
, Toronto,<country>Ontario</country>
</nlm:aff>
<wicri:noCountry code="nlm country">Ontario</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="aff12"><institution>Samuel Lunenfeld Research Institute, Mount Sinai Hospital</institution>
, Toronto,<country>Ontario</country>
</nlm:aff>
<wicri:noCountry code="nlm country">Ontario</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Glendon, G" sort="Glendon, G" uniqKey="Glendon G" first="G" last="Glendon">G. Glendon</name>
<affiliation><nlm:aff id="aff11"><institution>Department of Molecular Genetics, Ontario Cancer Genetics Network, Cancer Care Ontario and Samuel Lunenfeld Research Institute, Mount Sinai Hospital</institution>
, Toronto,<country>Ontario</country>
</nlm:aff>
<wicri:noCountry code="nlm country">Ontario</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ozcelik, H" sort="Ozcelik, H" uniqKey="Ozcelik H" first="H" last="Ozcelik">H. Ozcelik</name>
<affiliation><nlm:aff id="aff12"><institution>Samuel Lunenfeld Research Institute, Mount Sinai Hospital</institution>
, Toronto,<country>Ontario</country>
</nlm:aff>
<wicri:noCountry code="nlm country">Ontario</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Thomassen, M" sort="Thomassen, M" uniqKey="Thomassen M" first="M" last="Thomassen">M. Thomassen</name>
<affiliation wicri:level="1"><nlm:aff id="aff14"><institution>Department of Clinical Genetics, Odense University Hospital</institution>
, Odense,<country>Denmark</country>
</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Paligo, M" sort="Paligo, M" uniqKey="Paligo M" first="M" last="Paligo">M. Paligo</name>
<affiliation wicri:level="1"><nlm:aff id="aff15"><institution>Section of Genetic Oncology, University Hospital of Pisa</institution>
, Pisa,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Aretini, P" sort="Aretini, P" uniqKey="Aretini P" first="P" last="Aretini">P. Aretini</name>
<affiliation wicri:level="1"><nlm:aff id="aff15"><institution>Section of Genetic Oncology, University Hospital of Pisa</institution>
, Pisa,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kantala, J" sort="Kantala, J" uniqKey="Kantala J" first="J" last="Kantala">J. Kantala</name>
<affiliation wicri:level="1"><nlm:aff id="aff16"><institution>Department of Clinical Genetics, Karolinska University Hospital</institution>
, Stockholm,<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Aroer, B" sort="Aroer, B" uniqKey="Aroer B" first="B" last="Aroer">B. Aroer</name>
<affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Department of Oncology, Karolinska University Hospital</institution>
, Stockholm,<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Von Wachenfeldt, A" sort="Von Wachenfeldt, A" uniqKey="Von Wachenfeldt A" first="A" last="Von Wachenfeldt">A. Von Wachenfeldt</name>
<affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Department of Oncology, Karolinska University Hospital</institution>
, Stockholm,<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Liljegren, A" sort="Liljegren, A" uniqKey="Liljegren A" first="A" last="Liljegren">A. Liljegren</name>
<affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Department of Oncology, Karolinska University Hospital</institution>
, Stockholm,<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Loman, N" sort="Loman, N" uniqKey="Loman N" first="N" last="Loman">N. Loman</name>
<affiliation wicri:level="1"><nlm:aff id="aff18"><institution>Department of Oncology, Lund University Hospital</institution>
, Lund,<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Herbst, K" sort="Herbst, K" uniqKey="Herbst K" first="K" last="Herbst">K. Herbst</name>
<affiliation wicri:level="1"><nlm:aff id="aff18"><institution>Department of Oncology, Lund University Hospital</institution>
, Lund,<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kristoffersson, U" sort="Kristoffersson, U" uniqKey="Kristoffersson U" first="U" last="Kristoffersson">U. Kristoffersson</name>
<affiliation wicri:level="1"><nlm:aff id="aff19"><institution>Department of Clinical Genetics, Lund University Hospital</institution>
, Lund,<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rosenquist, R" sort="Rosenquist, R" uniqKey="Rosenquist R" first="R" last="Rosenquist">R. Rosenquist</name>
<affiliation wicri:level="1"><nlm:aff id="aff20"><institution>Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University</institution>
, Uppsala,<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Karlsson, P" sort="Karlsson, P" uniqKey="Karlsson P" first="P" last="Karlsson">P. Karlsson</name>
<affiliation wicri:level="1"><nlm:aff id="aff21"><institution>Department of Oncology, Sahlgrenska University Hospital</institution>
, Gothenburg,<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stenmark Askmalm, M" sort="Stenmark Askmalm, M" uniqKey="Stenmark Askmalm M" first="M" last="Stenmark-Askmalm">M. Stenmark-Askmalm</name>
<affiliation wicri:level="1"><nlm:aff id="aff22"><institution>Department of Oncology, University Hospital</institution>
, Linköping<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Melin, B" sort="Melin, B" uniqKey="Melin B" first="B" last="Melin">B. Melin</name>
<affiliation wicri:level="1"><nlm:aff id="aff23"><institution>Department of Radiation Sciences, Oncology, Umeå University</institution>
, Umeå,<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nathanson, K L" sort="Nathanson, K L" uniqKey="Nathanson K" first="K L" last="Nathanson">K L Nathanson</name>
<affiliation wicri:level="1"><nlm:aff id="aff24"><institution>Department of Medicine and Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania</institution>
, Philadelphia, PN,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Domchek, S M" sort="Domchek, S M" uniqKey="Domchek S" first="S M" last="Domchek">S M Domchek</name>
<affiliation wicri:level="1"><nlm:aff id="aff24"><institution>Department of Medicine and Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania</institution>
, Philadelphia, PN,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Byrski, T" sort="Byrski, T" uniqKey="Byrski T" first="T" last="Byrski">T. Byrski</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>
, Szczecin,<country>Poland</country>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Huzarski, T" sort="Huzarski, T" uniqKey="Huzarski T" first="T" last="Huzarski">T. Huzarski</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>
, Szczecin,<country>Poland</country>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gronwald, J" sort="Gronwald, J" uniqKey="Gronwald J" first="J" last="Gronwald">J. Gronwald</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>
, Szczecin,<country>Poland</country>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Menkiszak, J" sort="Menkiszak, J" uniqKey="Menkiszak J" first="J" last="Menkiszak">J. Menkiszak</name>
<affiliation wicri:level="1"><nlm:aff id="aff25"><institution>Chair and Department of Surgical Gynecology and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University</institution>
, Szczecin,<country>Poland</country>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cybulski, C" sort="Cybulski, C" uniqKey="Cybulski C" first="C" last="Cybulski">C. Cybulski</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>
, Szczecin,<country>Poland</country>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Serrano, P" sort="Serrano, P" uniqKey="Serrano P" first="P" last="Serrano">P. Serrano</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>
, Szczecin,<country>Poland</country>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Osorio, A" sort="Osorio, A" uniqKey="Osorio A" first="A" last="Osorio">A. Osorio</name>
<affiliation wicri:level="1"><nlm:aff id="aff26"><institution>Human Genetics Group and Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre</institution>
, Madrid,<country>Spain</country>
(and Spanish Network on Rare Diseases (CIBERER))</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cajal, T R" sort="Cajal, T R" uniqKey="Cajal T" first="T R" last="Cajal">T R Cajal</name>
<affiliation wicri:level="1"><nlm:aff id="aff27"><institution>Oncology Service, Hospital de la Santa Creu i Sant Pau</institution>
, Barcelona,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tsitlaidou, M" sort="Tsitlaidou, M" uniqKey="Tsitlaidou M" first="M" last="Tsitlaidou">M. Tsitlaidou</name>
<affiliation wicri:level="1"><nlm:aff id="aff28"><institution>Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research ‘Demokritos', Aghia Paraskevi Attikis</institution>
, Athens 15310,<country>Greece</country>
</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Benitez, J" sort="Benitez, J" uniqKey="Benitez J" first="J" last="Benítez">J. Benítez</name>
<affiliation wicri:level="1"><nlm:aff id="aff26"><institution>Human Genetics Group and Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre</institution>
, Madrid,<country>Spain</country>
(and Spanish Network on Rare Diseases (CIBERER))</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gilbert, M" sort="Gilbert, M" uniqKey="Gilbert M" first="M" last="Gilbert">M. Gilbert</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Functional Genome Analysis, Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ)</institution>
, Heidelberg,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rookus, M" sort="Rookus, M" uniqKey="Rookus M" first="M" last="Rookus">M. Rookus</name>
<affiliation wicri:level="1"><nlm:aff id="aff29"><institution>Department of Epidemiology, Netherlands Cancer Institute</institution>
, Amsterdam,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Aalfs, C M" sort="Aalfs, C M" uniqKey="Aalfs C" first="C M" last="Aalfs">C M Aalfs</name>
<affiliation wicri:level="1"><nlm:aff id="aff30"><institution>Department of Clinical Genetics, Academic Medical Center</institution>
, Amsterdam,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kluijt, I" sort="Kluijt, I" uniqKey="Kluijt I" first="I" last="Kluijt">I. Kluijt</name>
<affiliation wicri:level="1"><nlm:aff id="aff31"><institution>Department of Family Cancer Clinic, Netherlands Cancer Institute</institution>
, Amsterdam,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Boessenkool Pape, J L" sort="Boessenkool Pape, J L" uniqKey="Boessenkool Pape J" first="J L" last="Boessenkool-Pape">J L Boessenkool-Pape</name>
<affiliation wicri:level="1"><nlm:aff id="aff29"><institution>Department of Epidemiology, Netherlands Cancer Institute</institution>
, Amsterdam,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Meijers Heijboer, H E J" sort="Meijers Heijboer, H E J" uniqKey="Meijers Heijboer H" first="H E J" last="Meijers-Heijboer">H E J. Meijers-Heijboer</name>
<affiliation wicri:level="1"><nlm:aff id="aff32"><institution>Department of Clinical Genetics, VU Medical Center</institution>
, Amsterdam,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Oosterwijk, J C" sort="Oosterwijk, J C" uniqKey="Oosterwijk J" first="J C" last="Oosterwijk">J C Oosterwijk</name>
<affiliation wicri:level="1"><nlm:aff id="aff33"><institution>Department of Genetics, University Medical Center, Groningen University</institution>
, Groningen,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Asperen, C J" sort="Van Asperen, C J" uniqKey="Van Asperen C" first="C J" last="Van Asperen">C J Van Asperen</name>
<affiliation wicri:level="1"><nlm:aff id="aff34"><institution>Department of Clinical Genetics Leiden University Medical Center Leiden</institution>
, Leiden,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Blok, M J" sort="Blok, M J" uniqKey="Blok M" first="M J" last="Blok">M J Blok</name>
<affiliation wicri:level="1"><nlm:aff id="aff35"><institution>Department of Clinical Genetics, University Hospital Maastricht</institution>
, Maastricht,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nelen, M R" sort="Nelen, M R" uniqKey="Nelen M" first="M R" last="Nelen">M R Nelen</name>
<affiliation wicri:level="1"><nlm:aff id="aff36"><institution>Department of Human Genetics 849, Radboud University Nijmegen Medical Centre</institution>
, P.O. BOX 9101, HB Nijmegen, Nijmegen 6500,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Den Ouweland, A M W" sort="Van Den Ouweland, A M W" uniqKey="Van Den Ouweland A" first="A M W" last="Van Den Ouweland">A M W. Van Den Ouweland</name>
<affiliation wicri:level="1"><nlm:aff id="aff37"><institution>Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center</institution>
, Rotterdam,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Seynaeve, C" sort="Seynaeve, C" uniqKey="Seynaeve C" first="C" last="Seynaeve">C. Seynaeve</name>
<affiliation wicri:level="1"><nlm:aff id="aff38"><institution>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center</institution>
, Rotterdam,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Der Luijt, R B" sort="Van Der Luijt, R B" uniqKey="Van Der Luijt R" first="R B" last="Van Der Luijt">R B Van Der Luijt</name>
<affiliation wicri:level="1"><nlm:aff id="aff39"><institution>Department of Medical Genetics, University Medical Center Utrecht</institution>
, Utrecht,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Devilee, P" sort="Devilee, P" uniqKey="Devilee P" first="P" last="Devilee">P. Devilee</name>
<affiliation wicri:level="1"><nlm:aff id="aff40"><institution>Department of Human Genetics & Department of Pathology, Leiden University Medical Center</institution>
, Leiden,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Easton, D F" sort="Easton, D F" uniqKey="Easton D" first="D F" last="Easton">D F Easton</name>
<affiliation wicri:level="1"><nlm:aff id="aff41"><institution>Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>
, Cambridge,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peock, S" sort="Peock, S" uniqKey="Peock S" first="S" last="Peock">S. Peock</name>
<affiliation wicri:level="1"><nlm:aff id="aff41"><institution>Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>
, Cambridge,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Frost, D" sort="Frost, D" uniqKey="Frost D" first="D" last="Frost">D. Frost</name>
<affiliation wicri:level="1"><nlm:aff id="aff41"><institution>Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>
, Cambridge,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Platte, R" sort="Platte, R" uniqKey="Platte R" first="R" last="Platte">R. Platte</name>
<affiliation wicri:level="1"><nlm:aff id="aff41"><institution>Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>
, Cambridge,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ellis, S D" sort="Ellis, S D" uniqKey="Ellis S" first="S D" last="Ellis">S D Ellis</name>
<affiliation wicri:level="1"><nlm:aff id="aff41"><institution>Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>
, Cambridge,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fineberg, E" sort="Fineberg, E" uniqKey="Fineberg E" first="E" last="Fineberg">E. Fineberg</name>
<affiliation wicri:level="1"><nlm:aff id="aff41"><institution>Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>
, Cambridge,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Evans, D G" sort="Evans, D G" uniqKey="Evans D" first="D G" last="Evans">D G Evans</name>
<affiliation wicri:level="1"><nlm:aff id="aff42"><institution>Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust</institution>
, Manchester,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lalloo, F" sort="Lalloo, F" uniqKey="Lalloo F" first="F" last="Lalloo">F. Lalloo</name>
<affiliation wicri:level="1"><nlm:aff id="aff42"><institution>Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust</institution>
, Manchester,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eeles, R" sort="Eeles, R" uniqKey="Eeles R" first="R" last="Eeles">R. Eeles</name>
<affiliation wicri:level="1"><nlm:aff id="aff43"><institution>Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust</institution>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jacobs, C" sort="Jacobs, C" uniqKey="Jacobs C" first="C" last="Jacobs">C. Jacobs</name>
<affiliation wicri:level="1"><nlm:aff id="aff44"><institution>Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust</institution>
, London,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Adlard, J" sort="Adlard, J" uniqKey="Adlard J" first="J" last="Adlard">J. Adlard</name>
<affiliation wicri:level="1"><nlm:aff id="aff45"><institution>Yorkshire Regional Genetics Service</institution>
, Leeds,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Davidson, R" sort="Davidson, R" uniqKey="Davidson R" first="R" last="Davidson">R. Davidson</name>
<affiliation wicri:level="1"><nlm:aff id="aff46"><institution>Ferguson-Smith Centre for Clinical Genetics, Yorkhill Hospitals</institution>
, Glasgow,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eccles, D" sort="Eccles, D" uniqKey="Eccles D" first="D" last="Eccles">D. Eccles</name>
<affiliation wicri:level="1"><nlm:aff id="aff47"><institution>University of Southampton Faculty of Medicine, Southampton University Hospitals NHS Trust</institution>
, Southampton,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cole, T" sort="Cole, T" uniqKey="Cole T" first="T" last="Cole">T. Cole</name>
<affiliation wicri:level="1"><nlm:aff id="aff48"><institution>West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust</institution>
, Edgbaston, Birmingham,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cook, J" sort="Cook, J" uniqKey="Cook J" first="J" last="Cook">J. Cook</name>
<affiliation wicri:level="1"><nlm:aff id="aff49"><institution>Sheffield Clinical Genetics Service, Sheffield Children's Hospital</institution>
, Sheffield,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Godwin, A" sort="Godwin, A" uniqKey="Godwin A" first="A" last="Godwin">A. Godwin</name>
<affiliation wicri:level="1"><nlm:aff id="aff50"><institution>Department of Pathology and Laboratory Medicine, the University of Kansas Medical Center</institution>
, Kansas City, KS,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bove, B" sort="Bove, B" uniqKey="Bove B" first="B" last="Bove">B. Bove</name>
<affiliation wicri:level="1"><nlm:aff id="aff51"><institution>Clinical Molecular Genetics Laboratory, Fox Chase Cancer Center</institution>
, Philadelphia, PA,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stoppa Lyonnet, D" sort="Stoppa Lyonnet, D" uniqKey="Stoppa Lyonnet D" first="D" last="Stoppa-Lyonnet">D. Stoppa-Lyonnet</name>
<affiliation wicri:level="1"><nlm:aff id="aff53"><institution>Service de Génétique Oncologique, Département de Biologie des Tumeurs, Institut Curie</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff54"><institution>Unité INSERM U830, Institut Curie</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff55"><institution>Université Paris Descartes, Faculté de Médecine</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Caux Moncoutier, V" sort="Caux Moncoutier, V" uniqKey="Caux Moncoutier V" first="V" last="Caux-Moncoutier">V. Caux-Moncoutier</name>
<affiliation wicri:level="1"><nlm:aff id="aff53"><institution>Service de Génétique Oncologique, Département de Biologie des Tumeurs, Institut Curie</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Belotti, M" sort="Belotti, M" uniqKey="Belotti M" first="M" last="Belotti">M. Belotti</name>
<affiliation wicri:level="1"><nlm:aff id="aff53"><institution>Service de Génétique Oncologique, Département de Biologie des Tumeurs, Institut Curie</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tirapo, C" sort="Tirapo, C" uniqKey="Tirapo C" first="C" last="Tirapo">C. Tirapo</name>
<affiliation wicri:level="1"><nlm:aff id="aff53"><institution>Service de Génétique Oncologique, Département de Biologie des Tumeurs, Institut Curie</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mazoyer, S" sort="Mazoyer, S" uniqKey="Mazoyer S" first="S" last="Mazoyer">S. Mazoyer</name>
<affiliation wicri:level="1"><nlm:aff id="aff9"><institution>INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon</institution>
, Lyon,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Barjhoux, L" sort="Barjhoux, L" uniqKey="Barjhoux L" first="L" last="Barjhoux">L. Barjhoux</name>
<affiliation wicri:level="1"><nlm:aff id="aff9"><institution>INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon</institution>
, Lyon,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Boutry Kryza, N" sort="Boutry Kryza, N" uniqKey="Boutry Kryza N" first="N" last="Boutry-Kryza">N. Boutry-Kryza</name>
<affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon, Centre Hospitalier Universitaire de Lyon/Centre Léon Bérard</institution>
, Lyon,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pujol, P" sort="Pujol, P" uniqKey="Pujol P" first="P" last="Pujol">P. Pujol</name>
<affiliation wicri:level="1"><nlm:aff id="aff56"><institution>Unité d'Oncogénétique, CHU Arnaud de Villeneuve</institution>
, Montpellier,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff57"><institution>INSERM 896, CRCM Val d'Aurelle</institution>
, Montpellier,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Coupier, I" sort="Coupier, I" uniqKey="Coupier I" first="I" last="Coupier">I. Coupier</name>
<affiliation wicri:level="1"><nlm:aff id="aff56"><institution>Unité d'Oncogénétique, CHU Arnaud de Villeneuve</institution>
, Montpellier,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff58"><institution>Unité d'Oncogénétique, CRLCC Val d'Aurelle</institution>
, Montpellier,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peyrat, J P" sort="Peyrat, J P" uniqKey="Peyrat J" first="J-P" last="Peyrat">J-P Peyrat</name>
<affiliation wicri:level="1"><nlm:aff id="aff59"><institution>Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret</institution>
, Lille,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vennin, P" sort="Vennin, P" uniqKey="Vennin P" first="P" last="Vennin">P. Vennin</name>
<affiliation wicri:level="1"><nlm:aff id="aff60"><institution>Consultation d'Oncogénétique, Centre Oscar Lambret</institution>
, Lille,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Muller, D" sort="Muller, D" uniqKey="Muller D" first="D" last="Muller">D. Muller</name>
<affiliation wicri:level="1"><nlm:aff id="aff61"><institution>Unité d'Oncogénétique, CLCC Paul Strauss</institution>
, Strasbourg,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fricker, J P" sort="Fricker, J P" uniqKey="Fricker J" first="J-P" last="Fricker">J-P Fricker</name>
<affiliation wicri:level="1"><nlm:aff id="aff61"><institution>Unité d'Oncogénétique, CLCC Paul Strauss</institution>
, Strasbourg,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Venat Bouvet, L" sort="Venat Bouvet, L" uniqKey="Venat Bouvet L" first="L" last="Venat-Bouvet">L. Venat-Bouvet</name>
<affiliation wicri:level="1"><nlm:aff id="aff62"><institution>Department of Medical Oncology, Centre Hospitalier Universitaire Dupuytren</institution>
, Limoges,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Johannsson, O Th" sort="Johannsson, O Th" uniqKey="Johannsson O" first="O Th" last="Johannsson">O Th Johannsson</name>
<affiliation wicri:level="1"><nlm:aff id="aff63"><institution>Department of Oncology, Landspitali University Hospital</institution>
, Reykjavik,<country>Iceland</country>
</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff64"><institution>Faculity of Medicine, University of Iceland</institution>
, Reykjavik,<country>Iceland</country>
</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Isaacs, C" sort="Isaacs, C" uniqKey="Isaacs C" first="C" last="Isaacs">C. Isaacs</name>
<affiliation wicri:level="1"><nlm:aff id="aff65"><institution>Department of Medicine and Oncology, Georgetown University</institution>
, Washington, DC,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schmutzler, R" sort="Schmutzler, R" uniqKey="Schmutzler R" first="R" last="Schmutzler">R. Schmutzler</name>
<affiliation wicri:level="1"><nlm:aff id="aff66"><institution>Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), University hospital of Cologne</institution>
, Cologne,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wappenschmidt, B" sort="Wappenschmidt, B" uniqKey="Wappenschmidt B" first="B" last="Wappenschmidt">B. Wappenschmidt</name>
<affiliation wicri:level="1"><nlm:aff id="aff66"><institution>Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), University hospital of Cologne</institution>
, Cologne,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Meindl, A" sort="Meindl, A" uniqKey="Meindl A" first="A" last="Meindl">A. Meindl</name>
<affiliation wicri:level="1"><nlm:aff id="aff67"><institution>Department of Gynaecology and Obstetrics, Ludwig-Maximillians University Munich</institution>
, Munich,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Arnold, N" sort="Arnold, N" uniqKey="Arnold N" first="N" last="Arnold">N. Arnold</name>
<affiliation wicri:level="1"><nlm:aff id="aff68"><institution>Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University</institution>
, Kiel,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Varon Mateeva, R" sort="Varon Mateeva, R" uniqKey="Varon Mateeva R" first="R" last="Varon-Mateeva">R. Varon-Mateeva</name>
<affiliation wicri:level="1"><nlm:aff id="aff69"><institution>Institute of Human Genetics, Campus Virchov Klinikum</institution>
, Charite Berlin,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Niederacher, D" sort="Niederacher, D" uniqKey="Niederacher D" first="D" last="Niederacher">D. Niederacher</name>
<affiliation wicri:level="1"><nlm:aff id="aff70"><institution>Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University</institution>
, Düsseldorf,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sutter, C" sort="Sutter, C" uniqKey="Sutter C" first="C" last="Sutter">C. Sutter</name>
<affiliation wicri:level="1"><nlm:aff id="aff71"><institution>Institute of Human Genetics, Department of Human Genetics, University Hospital Heidelberg</institution>
, Heidelberg,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Deissler, H" sort="Deissler, H" uniqKey="Deissler H" first="H" last="Deissler">H. Deissler</name>
<affiliation wicri:level="1"><nlm:aff id="aff72"><institution>Department of Gynaecology and Obstetrics, University Hospital</institution>
, Ulm,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Preisler Adams, S" sort="Preisler Adams, S" uniqKey="Preisler Adams S" first="S" last="Preisler-Adams">S. Preisler-Adams</name>
<affiliation wicri:level="1"><nlm:aff id="aff73"><institution>Institute of Human Genetics, University of Münster</institution>
, Münster,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Simard, J" sort="Simard, J" uniqKey="Simard J" first="J" last="Simard">J. Simard</name>
<affiliation wicri:level="1"><nlm:aff id="aff74"><institution>Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University</institution>
, Quebec,<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Soucy, P" sort="Soucy, P" uniqKey="Soucy P" first="P" last="Soucy">P. Soucy</name>
<affiliation wicri:level="1"><nlm:aff id="aff74"><institution>Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University</institution>
, Quebec,<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Durocher, F" sort="Durocher, F" uniqKey="Durocher F" first="F" last="Durocher">F. Durocher</name>
<affiliation wicri:level="1"><nlm:aff id="aff74"><institution>Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University</institution>
, Quebec,<country>Canada</country>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chenevix Trench, G" sort="Chenevix Trench, G" uniqKey="Chenevix Trench G" first="G" last="Chenevix-Trench">G. Chenevix-Trench</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Genetics and Population Health Division, Queensland Institute of Medical Research</institution>
, Brisbane,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Beesley, J" sort="Beesley, J" uniqKey="Beesley J" first="J" last="Beesley">J. Beesley</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Genetics and Population Health Division, Queensland Institute of Medical Research</institution>
, Brisbane,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chen, X" sort="Chen, X" uniqKey="Chen X" first="X" last="Chen">X. Chen</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Genetics and Population Health Division, Queensland Institute of Medical Research</institution>
, Brisbane,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rebbeck, T" sort="Rebbeck, T" uniqKey="Rebbeck T" first="T" last="Rebbeck">T. Rebbeck</name>
<affiliation wicri:level="1"><nlm:aff id="aff76"><institution>Department of Biostatistics and Epidemiology, Perelman School of Medicine and Abramson Cancer Center, University of Pennsylvania</institution>
, Philadelphia, PA,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Couch, F" sort="Couch, F" uniqKey="Couch F" first="F" last="Couch">F. Couch</name>
<affiliation wicri:level="1"><nlm:aff id="aff77"><institution>Department of Laboratory Medicine and Pathology, Mayo Clinic</institution>
, Rochester, MN,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff78"><institution>Department of Health Sciences Research, Mayo Clinic</institution>
, Rochester, MN,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wang, X" sort="Wang, X" uniqKey="Wang X" first="X" last="Wang">X. Wang</name>
<affiliation wicri:level="1"><nlm:aff id="aff77"><institution>Department of Laboratory Medicine and Pathology, Mayo Clinic</institution>
, Rochester, MN,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lindor, N" sort="Lindor, N" uniqKey="Lindor N" first="N" last="Lindor">N. Lindor</name>
<affiliation wicri:level="1"><nlm:aff id="aff79"><institution>Department of Medical Genetics, Mayo Clinic</institution>
, Rochester, MN,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fredericksen, Z" sort="Fredericksen, Z" uniqKey="Fredericksen Z" first="Z" last="Fredericksen">Z. Fredericksen</name>
<affiliation wicri:level="1"><nlm:aff id="aff78"><institution>Department of Health Sciences Research, Mayo Clinic</institution>
, Rochester, MN,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pankratz, V S" sort="Pankratz, V S" uniqKey="Pankratz V" first="V S" last="Pankratz">V S Pankratz</name>
<affiliation wicri:level="1"><nlm:aff id="aff78"><institution>Department of Health Sciences Research, Mayo Clinic</institution>
, Rochester, MN,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peterlongo, P" sort="Peterlongo, P" uniqKey="Peterlongo P" first="P" last="Peterlongo">P. Peterlongo</name>
<affiliation wicri:level="1"><nlm:aff id="aff80"><institution>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predicted Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT)</institution>
, Milan,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff81"><institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare</institution>
, Milan,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bonanni, B" sort="Bonanni, B" uniqKey="Bonanni B" first="B" last="Bonanni">B. Bonanni</name>
<affiliation wicri:level="1"><nlm:aff id="aff82"><institution>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia</institution>
, Milan,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fortuzzi, S" sort="Fortuzzi, S" uniqKey="Fortuzzi S" first="S" last="Fortuzzi">S. Fortuzzi</name>
<affiliation wicri:level="1"><nlm:aff id="aff83"><institution>82-IFOM, Fondazione Istituto FIRC di Oncologia Molecolare and 84-Cogentech Cancer Genetic Test Laboratory</institution>
, Milan,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peissel, B" sort="Peissel, B" uniqKey="Peissel B" first="B" last="Peissel">B. Peissel</name>
<affiliation wicri:level="1"><nlm:aff id="aff84"><institution>Unit of Medical Genetics, Department of Preventive and Preventive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT)</institution>
, Milan,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Szabo, C" sort="Szabo, C" uniqKey="Szabo C" first="C" last="Szabo">C. Szabo</name>
<affiliation wicri:level="1"><nlm:aff id="aff85"><institution>Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine</institution>
, Rochester, MN,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mai, P L" sort="Mai, P L" uniqKey="Mai P" first="P L" last="Mai">P L Mai</name>
<affiliation wicri:level="1"><nlm:aff id="aff86"><institution>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services</institution>
, 6120 Executive Boulelvard, Rockville, MD 20852,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Loud, J T" sort="Loud, J T" uniqKey="Loud J" first="J T" last="Loud">J T Loud</name>
<affiliation wicri:level="1"><nlm:aff id="aff86"><institution>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services</institution>
, 6120 Executive Boulelvard, Rockville, MD 20852,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lubinski, J" sort="Lubinski, J" uniqKey="Lubinski J" first="J" last="Lubinski">J. Lubinski</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>
, Szczecin,<country>Poland</country>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">British Journal of Cancer</title>
<idno type="ISSN">0007-0920</idno>
<idno type="eISSN">1532-1827</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background:</title>
<p>The variable penetrance of breast cancer in <italic>BRCA1/2</italic>
mutation carriers suggests that other genetic or environmental factors modify breast cancer risk. Two genes of special interest are prohibitin (<italic>PHB</italic>
) and methylene-tetrahydrofolate reductase (<italic>MTHFR</italic>
), both of which are important either directly or indirectly in maintaining genomic integrity.</p>
</sec>
<sec><title>Methods:</title>
<p>To evaluate the potential role of genetic variants within <italic>PHB</italic>
and <italic>MTHFR</italic>
in breast and ovarian cancer risk, 4102 <italic>BRCA1</italic>
and 2093 <italic>BRCA2</italic>
mutation carriers, and 6211 <italic>BRCA1</italic>
and 2902 <italic>BRCA2</italic>
carriers from the Consortium of Investigators of Modifiers of <italic>BRCA1</italic>
and <italic>BRCA2</italic>
(CIMBA) were genotyped for the <italic>PHB</italic>
1630 C>T (rs6917) polymorphism and the <italic>MTHFR</italic>
677 C>T (rs1801133) polymorphism, respectively.</p>
</sec>
<sec><title>Results:</title>
<p>There was no evidence of association between the <italic>PHB</italic>
1630 C>T and <italic>MTHFR</italic>
677 C>T polymorphisms with either disease for <italic>BRCA1</italic>
or <italic>BRCA2</italic>
mutation carriers when breast and ovarian cancer associations were evaluated separately. Analysis that evaluated associations for breast and ovarian cancer simultaneously showed some evidence that <italic>BRCA1</italic>
mutation carriers who had the rare homozygote genotype (TT) of the <italic>PHB</italic>
1630 C>T polymorphism were at increased risk of both breast and ovarian cancer (HR 1.50, 95%CI 1.10–2.04 and HR 2.16, 95%CI 1.24–3.76, respectively). However, there was no evidence of association under a multiplicative model for the effect of each minor allele.</p>
</sec>
<sec><title>Conclusion:</title>
<p>The <italic>PHB</italic>
1630TT genotype may modify breast and ovarian cancer risks in <italic>BRCA1</italic>
mutation carriers. This association need to be evaluated in larger series of <italic>BRCA1</italic>
mutation carriers.</p>
</sec>
</div>
</front>
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<article-id pub-id-type="doi">10.1038/bjc.2012.160</article-id>
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<xref ref-type="aff" rid="aff42">42</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Eeles</surname>
<given-names>R</given-names>
</name>
<xref ref-type="aff" rid="aff43">43</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jacobs</surname>
<given-names>C</given-names>
</name>
<xref ref-type="aff" rid="aff44">44</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Adlard</surname>
<given-names>J</given-names>
</name>
<xref ref-type="aff" rid="aff45">45</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Davidson</surname>
<given-names>R</given-names>
</name>
<xref ref-type="aff" rid="aff46">46</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Eccles</surname>
<given-names>D</given-names>
</name>
<xref ref-type="aff" rid="aff47">47</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cole</surname>
<given-names>T</given-names>
</name>
<xref ref-type="aff" rid="aff48">48</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cook</surname>
<given-names>J</given-names>
</name>
<xref ref-type="aff" rid="aff49">49</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Godwin</surname>
<given-names>A</given-names>
</name>
<xref ref-type="aff" rid="aff50">50</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bove</surname>
<given-names>B</given-names>
</name>
<xref ref-type="aff" rid="aff51">51</xref>
</contrib>
<contrib contrib-type="author"><collab>GEMO Study Collaborators<xref ref-type="aff" rid="aff52">52</xref>
</collab>
</contrib>
<contrib contrib-type="author"><name><surname>Stoppa-Lyonnet</surname>
<given-names>D</given-names>
</name>
<xref ref-type="aff" rid="aff53">53</xref>
<xref ref-type="aff" rid="aff54">54</xref>
<xref ref-type="aff" rid="aff55">55</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Caux-Moncoutier</surname>
<given-names>V</given-names>
</name>
<xref ref-type="aff" rid="aff53">53</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Belotti</surname>
<given-names>M</given-names>
</name>
<xref ref-type="aff" rid="aff53">53</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tirapo</surname>
<given-names>C</given-names>
</name>
<xref ref-type="aff" rid="aff53">53</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mazoyer</surname>
<given-names>S</given-names>
</name>
<xref ref-type="aff" rid="aff9">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Barjhoux</surname>
<given-names>L</given-names>
</name>
<xref ref-type="aff" rid="aff9">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Boutry-Kryza</surname>
<given-names>N</given-names>
</name>
<xref ref-type="aff" rid="aff8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pujol</surname>
<given-names>P</given-names>
</name>
<xref ref-type="aff" rid="aff56">56</xref>
<xref ref-type="aff" rid="aff57">57</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Coupier</surname>
<given-names>I</given-names>
</name>
<xref ref-type="aff" rid="aff56">56</xref>
<xref ref-type="aff" rid="aff58">58</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Peyrat</surname>
<given-names>J-P</given-names>
</name>
<xref ref-type="aff" rid="aff59">59</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vennin</surname>
<given-names>P</given-names>
</name>
<xref ref-type="aff" rid="aff60">60</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Muller</surname>
<given-names>D</given-names>
</name>
<xref ref-type="aff" rid="aff61">61</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fricker</surname>
<given-names>J-P</given-names>
</name>
<xref ref-type="aff" rid="aff61">61</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Venat-Bouvet</surname>
<given-names>L</given-names>
</name>
<xref ref-type="aff" rid="aff62">62</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Johannsson</surname>
<given-names>O Th</given-names>
</name>
<xref ref-type="aff" rid="aff63">63</xref>
<xref ref-type="aff" rid="aff64">64</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Isaacs</surname>
<given-names>C</given-names>
</name>
<xref ref-type="aff" rid="aff65">65</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schmutzler</surname>
<given-names>R</given-names>
</name>
<xref ref-type="aff" rid="aff66">66</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wappenschmidt</surname>
<given-names>B</given-names>
</name>
<xref ref-type="aff" rid="aff66">66</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Meindl</surname>
<given-names>A</given-names>
</name>
<xref ref-type="aff" rid="aff67">67</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Arnold</surname>
<given-names>N</given-names>
</name>
<xref ref-type="aff" rid="aff68">68</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Varon-Mateeva</surname>
<given-names>R</given-names>
</name>
<xref ref-type="aff" rid="aff69">69</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Niederacher</surname>
<given-names>D</given-names>
</name>
<xref ref-type="aff" rid="aff70">70</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sutter</surname>
<given-names>C</given-names>
</name>
<xref ref-type="aff" rid="aff71">71</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Deissler</surname>
<given-names>H</given-names>
</name>
<xref ref-type="aff" rid="aff72">72</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Preisler-Adams</surname>
<given-names>S</given-names>
</name>
<xref ref-type="aff" rid="aff73">73</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Simard</surname>
<given-names>J</given-names>
</name>
<xref ref-type="aff" rid="aff74">74</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Soucy</surname>
<given-names>P</given-names>
</name>
<xref ref-type="aff" rid="aff74">74</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Durocher</surname>
<given-names>F</given-names>
</name>
<xref ref-type="aff" rid="aff74">74</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chenevix-Trench</surname>
<given-names>G</given-names>
</name>
<xref ref-type="aff" rid="aff7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Beesley</surname>
<given-names>J</given-names>
</name>
<xref ref-type="aff" rid="aff7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chen</surname>
<given-names>X</given-names>
</name>
<xref ref-type="aff" rid="aff7">7</xref>
</contrib>
<contrib contrib-type="author"><collab>KConFab<xref ref-type="aff" rid="aff75">75</xref>
</collab>
</contrib>
<contrib contrib-type="author"><name><surname>Rebbeck</surname>
<given-names>T</given-names>
</name>
<xref ref-type="aff" rid="aff76">76</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Couch</surname>
<given-names>F</given-names>
</name>
<xref ref-type="aff" rid="aff77">77</xref>
<xref ref-type="aff" rid="aff78">78</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>X</given-names>
</name>
<xref ref-type="aff" rid="aff77">77</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lindor</surname>
<given-names>N</given-names>
</name>
<xref ref-type="aff" rid="aff79">79</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fredericksen</surname>
<given-names>Z</given-names>
</name>
<xref ref-type="aff" rid="aff78">78</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pankratz</surname>
<given-names>V S</given-names>
</name>
<xref ref-type="aff" rid="aff78">78</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Peterlongo</surname>
<given-names>P</given-names>
</name>
<xref ref-type="aff" rid="aff80">80</xref>
<xref ref-type="aff" rid="aff81">81</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bonanni</surname>
<given-names>B</given-names>
</name>
<xref ref-type="aff" rid="aff82">82</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fortuzzi</surname>
<given-names>S</given-names>
</name>
<xref ref-type="aff" rid="aff83">83</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Peissel</surname>
<given-names>B</given-names>
</name>
<xref ref-type="aff" rid="aff84">84</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Szabo</surname>
<given-names>C</given-names>
</name>
<xref ref-type="aff" rid="aff85">85</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mai</surname>
<given-names>P L</given-names>
</name>
<xref ref-type="aff" rid="aff86">86</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Loud</surname>
<given-names>J T</given-names>
</name>
<xref ref-type="aff" rid="aff86">86</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lubinski</surname>
<given-names>J</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<on-behalf-of>on behalf of CIMBA, the Consortium of Investigators of Modifiers of BRCA1/2-Related Cancer</on-behalf-of>
<aff id="aff1"><label>1</label>
<institution>Department of Genetics and Pathology, Pomeranian Medical University</institution>
, Szczecin,<country>Poland</country>
</aff>
<aff id="aff2"><label>2</label>
<institution>Department of Statistics and Econometrics, School of Economics and Management, University of Szczecin</institution>
, Szczecin,<country>Poland</country>
</aff>
<aff id="aff3"><label>3</label>
<institution>Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory</institution>
, Cambridge,<country>UK</country>
</aff>
<aff id="aff4"><label>4</label>
<institution>Department of Functional Genome Analysis, Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ)</institution>
, Heidelberg,<country>Germany</country>
</aff>
<aff id="aff5"><label>5</label>
<institution>Department of Medical Genetics, Faculty of Health, University of Newcastle, and the Hunter Medical Research Institute</institution>
, NSW,<country>Australia</country>
</aff>
<aff id="aff6"><label>6</label>
<institution>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge</institution>
, Cambridge,<country>UK</country>
</aff>
<aff id="aff7"><label>7</label>
<institution>Genetics and Population Health Division, Queensland Institute of Medical Research</institution>
, Brisbane,<country>Australia</country>
</aff>
<aff id="aff8"><label>8</label>
<institution>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon, Centre Hospitalier Universitaire de Lyon/Centre Léon Bérard</institution>
, Lyon,<country>France</country>
</aff>
<aff id="aff9"><label>9</label>
<institution>INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon</institution>
, Lyon,<country>France</country>
</aff>
<aff id="aff10"><label>10</label>
<institution>Department of Community Medicine and Epidemiology and Clalit National Cancer Control Center, Carmel Medical Center and B Rappaport Faculty of Medicine, Technion</institution>
, Haifa,<country>Israel</country>
</aff>
<aff id="aff11"><label>11</label>
<institution>Department of Molecular Genetics, Ontario Cancer Genetics Network, Cancer Care Ontario and Samuel Lunenfeld Research Institute, Mount Sinai Hospital</institution>
, Toronto,<country>Ontario</country>
</aff>
<aff id="aff12"><label>12</label>
<institution>Samuel Lunenfeld Research Institute, Mount Sinai Hospital</institution>
, Toronto,<country>Ontario</country>
</aff>
<aff id="aff13"><label>13</label>
<institution>Ontario Cancer Genetics Network (OCGN), Cancer Care Ontario</institution>
, Toronto, ON,<country>Canada</country>
</aff>
<aff id="aff14"><label>14</label>
<institution>Department of Clinical Genetics, Odense University Hospital</institution>
, Odense,<country>Denmark</country>
</aff>
<aff id="aff15"><label>15</label>
<institution>Section of Genetic Oncology, University Hospital of Pisa</institution>
, Pisa,<country>Italy</country>
</aff>
<aff id="aff16"><label>16</label>
<institution>Department of Clinical Genetics, Karolinska University Hospital</institution>
, Stockholm,<country>Sweden</country>
</aff>
<aff id="aff17"><label>17</label>
<institution>Department of Oncology, Karolinska University Hospital</institution>
, Stockholm,<country>Sweden</country>
</aff>
<aff id="aff18"><label>18</label>
<institution>Department of Oncology, Lund University Hospital</institution>
, Lund,<country>Sweden</country>
</aff>
<aff id="aff19"><label>19</label>
<institution>Department of Clinical Genetics, Lund University Hospital</institution>
, Lund,<country>Sweden</country>
</aff>
<aff id="aff20"><label>20</label>
<institution>Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University</institution>
, Uppsala,<country>Sweden</country>
</aff>
<aff id="aff21"><label>21</label>
<institution>Department of Oncology, Sahlgrenska University Hospital</institution>
, Gothenburg,<country>Sweden</country>
</aff>
<aff id="aff22"><label>22</label>
<institution>Department of Oncology, University Hospital</institution>
, Linköping<country>Sweden</country>
</aff>
<aff id="aff23"><label>23</label>
<institution>Department of Radiation Sciences, Oncology, Umeå University</institution>
, Umeå,<country>Sweden</country>
</aff>
<aff id="aff24"><label>24</label>
<institution>Department of Medicine and Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania</institution>
, Philadelphia, PN,<country>USA</country>
</aff>
<aff id="aff25"><label>25</label>
<institution>Chair and Department of Surgical Gynecology and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University</institution>
, Szczecin,<country>Poland</country>
</aff>
<aff id="aff26"><label>26</label>
<institution>Human Genetics Group and Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre</institution>
, Madrid,<country>Spain</country>
(and Spanish Network on Rare Diseases (CIBERER))</aff>
<aff id="aff27"><label>27</label>
<institution>Oncology Service, Hospital de la Santa Creu i Sant Pau</institution>
, Barcelona,<country>Spain</country>
</aff>
<aff id="aff28"><label>28</label>
<institution>Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research ‘Demokritos', Aghia Paraskevi Attikis</institution>
, Athens 15310,<country>Greece</country>
</aff>
<aff id="aff29"><label>29</label>
<institution>Department of Epidemiology, Netherlands Cancer Institute</institution>
, Amsterdam,<country>The Netherlands</country>
</aff>
<aff id="aff30"><label>30</label>
<institution>Department of Clinical Genetics, Academic Medical Center</institution>
, Amsterdam,<country>The Netherlands</country>
</aff>
<aff id="aff31"><label>31</label>
<institution>Department of Family Cancer Clinic, Netherlands Cancer Institute</institution>
, Amsterdam,<country>The Netherlands</country>
</aff>
<aff id="aff32"><label>32</label>
<institution>Department of Clinical Genetics, VU Medical Center</institution>
, Amsterdam,<country>The Netherlands</country>
</aff>
<aff id="aff33"><label>33</label>
<institution>Department of Genetics, University Medical Center, Groningen University</institution>
, Groningen,<country>The Netherlands</country>
</aff>
<aff id="aff34"><label>34</label>
<institution>Department of Clinical Genetics Leiden University Medical Center Leiden</institution>
, Leiden,<country>The Netherlands</country>
</aff>
<aff id="aff35"><label>35</label>
<institution>Department of Clinical Genetics, University Hospital Maastricht</institution>
, Maastricht,<country>The Netherlands</country>
</aff>
<aff id="aff36"><label>36</label>
<institution>Department of Human Genetics 849, Radboud University Nijmegen Medical Centre</institution>
, P.O. BOX 9101, HB Nijmegen, Nijmegen 6500,<country>The Netherlands</country>
</aff>
<aff id="aff37"><label>37</label>
<institution>Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center</institution>
, Rotterdam,<country>The Netherlands</country>
</aff>
<aff id="aff38"><label>38</label>
<institution>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center</institution>
, Rotterdam,<country>The Netherlands</country>
</aff>
<aff id="aff39"><label>39</label>
<institution>Department of Medical Genetics, University Medical Center Utrecht</institution>
, Utrecht,<country>The Netherlands</country>
</aff>
<aff id="aff40"><label>40</label>
<institution>Department of Human Genetics & Department of Pathology, Leiden University Medical Center</institution>
, Leiden,<country>The Netherlands</country>
</aff>
<aff id="aff41"><label>41</label>
<institution>Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge</institution>
, Cambridge,<country>UK</country>
</aff>
<aff id="aff42"><label>42</label>
<institution>Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust</institution>
, Manchester,<country>UK</country>
</aff>
<aff id="aff43"><label>43</label>
<institution>Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust</institution>
,<country>UK</country>
</aff>
<aff id="aff44"><label>44</label>
<institution>Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust</institution>
, London,<country>UK</country>
</aff>
<aff id="aff45"><label>45</label>
<institution>Yorkshire Regional Genetics Service</institution>
, Leeds,<country>UK</country>
</aff>
<aff id="aff46"><label>46</label>
<institution>Ferguson-Smith Centre for Clinical Genetics, Yorkhill Hospitals</institution>
, Glasgow,<country>UK</country>
</aff>
<aff id="aff47"><label>47</label>
<institution>University of Southampton Faculty of Medicine, Southampton University Hospitals NHS Trust</institution>
, Southampton,<country>UK</country>
</aff>
<aff id="aff48"><label>48</label>
<institution>West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust</institution>
, Edgbaston, Birmingham,<country>UK</country>
</aff>
<aff id="aff49"><label>49</label>
<institution>Sheffield Clinical Genetics Service, Sheffield Children's Hospital</institution>
, Sheffield,<country>UK</country>
</aff>
<aff id="aff50"><label>50</label>
<institution>Department of Pathology and Laboratory Medicine, the University of Kansas Medical Center</institution>
, Kansas City, KS,<country>USA</country>
</aff>
<aff id="aff51"><label>51</label>
<institution>Clinical Molecular Genetics Laboratory, Fox Chase Cancer Center</institution>
, Philadelphia, PA,<country>USA</country>
</aff>
<aff id="aff52"><label>52</label>
<institution>Cancer Genetics Network ‘Groupe Génétique et Cancer', Fédération Nationale des Centres de Lutte Contre le Cancer</institution>
,<country>France</country>
</aff>
<aff id="aff53"><label>53</label>
<institution>Service de Génétique Oncologique, Département de Biologie des Tumeurs, Institut Curie</institution>
, Paris,<country>France</country>
</aff>
<aff id="aff54"><label>54</label>
<institution>Unité INSERM U830, Institut Curie</institution>
, Paris,<country>France</country>
</aff>
<aff id="aff55"><label>55</label>
<institution>Université Paris Descartes, Faculté de Médecine</institution>
, Paris,<country>France</country>
</aff>
<aff id="aff56"><label>56</label>
<institution>Unité d'Oncogénétique, CHU Arnaud de Villeneuve</institution>
, Montpellier,<country>France</country>
</aff>
<aff id="aff57"><label>57</label>
<institution>INSERM 896, CRCM Val d'Aurelle</institution>
, Montpellier,<country>France</country>
</aff>
<aff id="aff58"><label>58</label>
<institution>Unité d'Oncogénétique, CRLCC Val d'Aurelle</institution>
, Montpellier,<country>France</country>
</aff>
<aff id="aff59"><label>59</label>
<institution>Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret</institution>
, Lille,<country>France</country>
</aff>
<aff id="aff60"><label>60</label>
<institution>Consultation d'Oncogénétique, Centre Oscar Lambret</institution>
, Lille,<country>France</country>
</aff>
<aff id="aff61"><label>61</label>
<institution>Unité d'Oncogénétique, CLCC Paul Strauss</institution>
, Strasbourg,<country>France</country>
</aff>
<aff id="aff62"><label>62</label>
<institution>Department of Medical Oncology, Centre Hospitalier Universitaire Dupuytren</institution>
, Limoges,<country>France</country>
</aff>
<aff id="aff63"><label>63</label>
<institution>Department of Oncology, Landspitali University Hospital</institution>
, Reykjavik,<country>Iceland</country>
</aff>
<aff id="aff64"><label>64</label>
<institution>Faculity of Medicine, University of Iceland</institution>
, Reykjavik,<country>Iceland</country>
</aff>
<aff id="aff65"><label>65</label>
<institution>Department of Medicine and Oncology, Georgetown University</institution>
, Washington, DC,<country>USA</country>
</aff>
<aff id="aff66"><label>66</label>
<institution>Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), University hospital of Cologne</institution>
, Cologne,<country>Germany</country>
</aff>
<aff id="aff67"><label>67</label>
<institution>Department of Gynaecology and Obstetrics, Ludwig-Maximillians University Munich</institution>
, Munich,<country>Germany</country>
</aff>
<aff id="aff68"><label>68</label>
<institution>Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University</institution>
, Kiel,<country>Germany</country>
</aff>
<aff id="aff69"><label>69</label>
<institution>Institute of Human Genetics, Campus Virchov Klinikum</institution>
, Charite Berlin,<country>Germany</country>
</aff>
<aff id="aff70"><label>70</label>
<institution>Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University</institution>
, Düsseldorf,<country>Germany</country>
</aff>
<aff id="aff71"><label>71</label>
<institution>Institute of Human Genetics, Department of Human Genetics, University Hospital Heidelberg</institution>
, Heidelberg,<country>Germany</country>
</aff>
<aff id="aff72"><label>72</label>
<institution>Department of Gynaecology and Obstetrics, University Hospital</institution>
, Ulm,<country>Germany</country>
</aff>
<aff id="aff73"><label>73</label>
<institution>Institute of Human Genetics, University of Münster</institution>
, Münster,<country>Germany</country>
</aff>
<aff id="aff74"><label>74</label>
<institution>Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University</institution>
, Quebec,<country>Canada</country>
</aff>
<aff id="aff75"><label>75</label>
<institution>kConFab Investigators–Peter MacCallum Cancer Center, East Melbourne</institution>
, VIC,<country>Australia</country>
</aff>
<aff id="aff76"><label>76</label>
<institution>Department of Biostatistics and Epidemiology, Perelman School of Medicine and Abramson Cancer Center, University of Pennsylvania</institution>
, Philadelphia, PA,<country>USA</country>
</aff>
<aff id="aff77"><label>77</label>
<institution>Department of Laboratory Medicine and Pathology, Mayo Clinic</institution>
, Rochester, MN,<country>USA</country>
</aff>
<aff id="aff78"><label>78</label>
<institution>Department of Health Sciences Research, Mayo Clinic</institution>
, Rochester, MN,<country>USA</country>
</aff>
<aff id="aff79"><label>79</label>
<institution>Department of Medical Genetics, Mayo Clinic</institution>
, Rochester, MN,<country>USA</country>
</aff>
<aff id="aff80"><label>80</label>
<institution>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predicted Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT)</institution>
, Milan,<country>Italy</country>
</aff>
<aff id="aff81"><label>81</label>
<institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare</institution>
, Milan,<country>Italy</country>
</aff>
<aff id="aff82"><label>82</label>
<institution>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia</institution>
, Milan,<country>Italy</country>
</aff>
<aff id="aff83"><label>83</label>
<institution>82-IFOM, Fondazione Istituto FIRC di Oncologia Molecolare and 84-Cogentech Cancer Genetic Test Laboratory</institution>
, Milan,<country>Italy</country>
</aff>
<aff id="aff84"><label>84</label>
<institution>Unit of Medical Genetics, Department of Preventive and Preventive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT)</institution>
, Milan,<country>Italy</country>
</aff>
<aff id="aff85"><label>85</label>
<institution>Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine</institution>
, Rochester, MN,<country>USA</country>
</aff>
<aff id="aff86"><label>86</label>
<institution>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services</institution>
, 6120 Executive Boulelvard, Rockville, MD 20852,<country>USA</country>
</aff>
</contrib-group>
<author-notes><corresp id="caf1"><label>*</label>
E-mail: <email>aniaj@sci.pam.szczecin.pl</email>
</corresp>
<fn fn-type="present-address" id="note1"><label>87</label>
<p>See Acknowledgements</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><day>05</day>
<month>06</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="epub"><day>15</day>
<month>05</month>
<year>2012</year>
</pub-date>
<volume>106</volume>
<issue>12</issue>
<fpage>2016</fpage>
<lpage>2024</lpage>
<history><date date-type="received"><day>14</day>
<month>11</month>
<year>2011</year>
</date>
<date date-type="rev-recd"><day>18</day>
<month>03</month>
<year>2012</year>
</date>
<date date-type="accepted"><day>25</day>
<month>03</month>
<year>2012</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2012 Cancer Research UK</copyright-statement>
<copyright-year>2012</copyright-year>
<copyright-holder>Cancer Research UK</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0/"><license-p>From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/</license-p>
</license>
</permissions>
<abstract><sec><title>Background:</title>
<p>The variable penetrance of breast cancer in <italic>BRCA1/2</italic>
mutation carriers suggests that other genetic or environmental factors modify breast cancer risk. Two genes of special interest are prohibitin (<italic>PHB</italic>
) and methylene-tetrahydrofolate reductase (<italic>MTHFR</italic>
), both of which are important either directly or indirectly in maintaining genomic integrity.</p>
</sec>
<sec><title>Methods:</title>
<p>To evaluate the potential role of genetic variants within <italic>PHB</italic>
and <italic>MTHFR</italic>
in breast and ovarian cancer risk, 4102 <italic>BRCA1</italic>
and 2093 <italic>BRCA2</italic>
mutation carriers, and 6211 <italic>BRCA1</italic>
and 2902 <italic>BRCA2</italic>
carriers from the Consortium of Investigators of Modifiers of <italic>BRCA1</italic>
and <italic>BRCA2</italic>
(CIMBA) were genotyped for the <italic>PHB</italic>
1630 C>T (rs6917) polymorphism and the <italic>MTHFR</italic>
677 C>T (rs1801133) polymorphism, respectively.</p>
</sec>
<sec><title>Results:</title>
<p>There was no evidence of association between the <italic>PHB</italic>
1630 C>T and <italic>MTHFR</italic>
677 C>T polymorphisms with either disease for <italic>BRCA1</italic>
or <italic>BRCA2</italic>
mutation carriers when breast and ovarian cancer associations were evaluated separately. Analysis that evaluated associations for breast and ovarian cancer simultaneously showed some evidence that <italic>BRCA1</italic>
mutation carriers who had the rare homozygote genotype (TT) of the <italic>PHB</italic>
1630 C>T polymorphism were at increased risk of both breast and ovarian cancer (HR 1.50, 95%CI 1.10–2.04 and HR 2.16, 95%CI 1.24–3.76, respectively). However, there was no evidence of association under a multiplicative model for the effect of each minor allele.</p>
</sec>
<sec><title>Conclusion:</title>
<p>The <italic>PHB</italic>
1630TT genotype may modify breast and ovarian cancer risks in <italic>BRCA1</italic>
mutation carriers. This association need to be evaluated in larger series of <italic>BRCA1</italic>
mutation carriers.</p>
</sec>
</abstract>
<kwd-group><kwd><italic>BRCA1/2</italic>
mutation carriers</kwd>
<kwd><italic>PHB</italic>
1630 C>T polymorphism</kwd>
<kwd>MTHFR 677 C>T polymorphism</kwd>
<kwd>breast/ovarian cancer risk</kwd>
</kwd-group>
</article-meta>
</front>
<floats-group><table-wrap id="tbl1"><label>Table 1</label>
<caption><title>Number of <italic>BRCA1</italic>
and <italic>BRCA2</italic>
carriers by study group and genotyping platforms</title>
</caption>
<table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col>
<col align="left"></col>
<col align="char" char="."></col>
<col align="char" char="."></col>
<col align="left"></col>
</colgroup>
<thead valign="bottom"><tr><th align="left" valign="top" charoff="50"><bold>Study</bold>
</th>
<th align="left" valign="top" charoff="50"><bold>Country<xref ref-type="fn" rid="t1-fn2">a</xref>
</bold>
</th>
<th align="center" valign="top" char="." charoff="50"><italic><bold>BRCA1, N</bold>
</italic>
</th>
<th align="center" valign="top" char="." charoff="50"><italic><bold>BRCA2, N</bold>
</italic>
</th>
<th align="left" valign="top" charoff="50"><bold>Genotyping Platform</bold>
</th>
</tr>
</thead>
<tbody valign="top"><tr><td colspan="5" align="left" valign="top" charoff="50"><italic><bold>PHB</bold>
</italic>
<bold>1630 C>T</bold>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Epidemiological study of BRCA1 & BRCA2 mutation carriers (EMBRACE)</td>
<td align="left" valign="top" charoff="50">UK and Eire</td>
<td align="char" valign="top" char="." charoff="50">823</td>
<td align="char" valign="top" char="." charoff="50">651</td>
<td align="left" valign="top" charoff="50">iPLEX</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Fox Chase Cancer Centre (FCCC)</td>
<td align="left" valign="top" charoff="50">USA</td>
<td align="char" valign="top" char="." charoff="50">78</td>
<td align="char" valign="top" char="." charoff="50">51</td>
<td align="left" valign="top" charoff="50">iPLEX</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Georgetown University</td>
<td align="left" valign="top" charoff="50">USA</td>
<td align="char" valign="top" char="." charoff="50">32</td>
<td align="char" valign="top" char="." charoff="50">15</td>
<td align="left" valign="top" charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Hereditary Breast and Ovarian study Netherlands (HEBON)</td>
<td align="left" valign="top" charoff="50">The Netherlands</td>
<td align="char" valign="top" char="." charoff="50">760</td>
<td align="char" valign="top" char="." charoff="50">285</td>
<td align="left" valign="top" charoff="50">iPLEX</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Helsinki Breast Cancer Study (HEBCS)</td>
<td align="left" valign="top" charoff="50">Finland</td>
<td align="char" valign="top" char="." charoff="50">103</td>
<td align="char" valign="top" char="." charoff="50">104</td>
<td align="left" valign="top" charoff="50">iPLEX</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> International Hereditary Cancer Centre (IHCC)</td>
<td align="left" valign="top" charoff="50">Poland</td>
<td align="char" valign="top" char="." charoff="50">696</td>
<td align="char" valign="top" char="." charoff="50">0</td>
<td align="left" valign="top" charoff="50">PCR-RFLP</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Iceland Landspitali - University Hospital (ILUH)</td>
<td align="left" valign="top" charoff="50">Iceland</td>
<td align="char" valign="top" char="." charoff="50">0</td>
<td align="char" valign="top" char="." charoff="50">86</td>
<td align="left" valign="top" charoff="50">iPLEX</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Interdisciplinary Health Research International Team Breast Cancer Susceptibility (INHERIT BRCAs)</td>
<td align="left" valign="top" charoff="50">Quebec -Canada</td>
<td align="char" valign="top" char="." charoff="50">73</td>
<td align="char" valign="top" char="." charoff="50">82</td>
<td align="left" valign="top" charoff="50">Taqman</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> kConFab</td>
<td align="left" valign="top" charoff="50">Australia</td>
<td align="char" valign="top" char="." charoff="50">519</td>
<td align="char" valign="top" char="." charoff="50">415</td>
<td align="left" valign="top" charoff="50">iPLEX</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Mayo Clinic (MAYO)</td>
<td align="left" valign="top" charoff="50">USA</td>
<td align="char" valign="top" char="." charoff="50">214</td>
<td align="char" valign="top" char="." charoff="50">115</td>
<td align="left" valign="top" charoff="50">iPLEX</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Pisa Breast Cancer Study (PBCS)</td>
<td align="left" valign="top" charoff="50">Italy</td>
<td align="char" valign="top" char="." charoff="50">76</td>
<td align="char" valign="top" char="." charoff="50">41</td>
<td align="left" valign="top" charoff="50">iPLEX</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Swedish Breast Cancer Study (SWE-BRCA)</td>
<td align="left" valign="top" charoff="50">Sweden</td>
<td align="char" valign="top" char="." charoff="50">468</td>
<td align="char" valign="top" char="." charoff="50">127</td>
<td align="left" valign="top" charoff="50">iPLEX</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> University of Pennsylvania (UPENN)</td>
<td align="left" valign="top" charoff="50">USA</td>
<td align="char" valign="top" char="." charoff="50">260</td>
<td align="char" valign="top" char="." charoff="50">121</td>
<td align="left" valign="top" charoff="50">iPLEX</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Total</td>
<td align="left" valign="top" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50">4102</td>
<td align="char" valign="top" char="." charoff="50">2093</td>
<td align="left" valign="top" charoff="50"> </td>
</tr>
<tr><td colspan="5" align="left" valign="top" charoff="50"> </td>
</tr>
<tr><td colspan="5" align="left" valign="top" charoff="50"><italic><bold>MTHFR</bold>
</italic>
<bold>677 C>T</bold>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Spanish National Cancer Centre (CNIO)</td>
<td align="left" valign="top" charoff="50">Spain, Greece</td>
<td align="char" valign="top" char="." charoff="50">168</td>
<td align="char" valign="top" char="." charoff="50">202</td>
<td align="left" valign="top" charoff="50">Taqman</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Deutsches Krebsforschungszentrum (DKFZ)</td>
<td align="left" valign="top" charoff="50">Germany</td>
<td align="char" valign="top" char="." charoff="50">68</td>
<td align="char" valign="top" char="." charoff="50">29</td>
<td align="left" valign="top" charoff="50">Taqman</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Epidemiological study of BRCA1 & BRCA2 mutation carriers (EMBRACE)</td>
<td align="left" valign="top" charoff="50">UK and Eire</td>
<td align="char" valign="top" char="." charoff="50">642</td>
<td align="char" valign="top" char="." charoff="50">469</td>
<td align="left" valign="top" charoff="50">iPlex</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Fox Chase Cancer Centre (FCCC)</td>
<td align="left" valign="top" charoff="50">USA</td>
<td align="char" valign="top" char="." charoff="50">80</td>
<td align="char" valign="top" char="." charoff="50">54</td>
<td align="left" valign="top" charoff="50">iPlex</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> German Consortium of Hereditary Breast and Ovarian Cancer (GC-HBOC)</td>
<td align="left" valign="top" charoff="50">Germany</td>
<td align="char" valign="top" char="." charoff="50">559</td>
<td align="char" valign="top" char="." charoff="50">283</td>
<td align="left" valign="top" charoff="50">Taqman</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Genetic modifiers of cancer risk in <italic>BRCA1</italic>
/2 mutation carriers (GEMO)</td>
<td align="left" valign="top" charoff="50">France, USA</td>
<td align="char" valign="top" char="." charoff="50">1075</td>
<td align="char" valign="top" char="." charoff="50">536</td>
<td align="left" valign="top" charoff="50">iPlex</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Hereditary Breast and Ovarian study Netherlands (HEBON)</td>
<td align="left" valign="top" charoff="50">The Netherlands</td>
<td align="char" valign="top" char="." charoff="50">480</td>
<td align="char" valign="top" char="." charoff="50">0</td>
<td align="left" valign="top" charoff="50">iPlex</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Helsinki Breast Cancer Study (HEBCS)</td>
<td align="left" valign="top" charoff="50">Finland</td>
<td align="char" valign="top" char="." charoff="50">101</td>
<td align="char" valign="top" char="." charoff="50">103</td>
<td align="left" valign="top" charoff="50">iPlex</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> International Hereditary Cancer Centre (IHCC)</td>
<td align="left" valign="top" charoff="50">Poland</td>
<td align="char" valign="top" char="." charoff="50">686</td>
<td align="char" valign="top" char="." charoff="50">0</td>
<td align="left" valign="top" charoff="50">PCR-RFLP</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Interdisciplinary Health Research International Team Breast Cancer Susceptibility (INHERIT BRCAs)</td>
<td align="left" valign="top" charoff="50">Quebec -Canada</td>
<td align="char" valign="top" char="." charoff="50">72</td>
<td align="char" valign="top" char="." charoff="50">82</td>
<td align="left" valign="top" charoff="50">Taqman</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> kConFab</td>
<td align="left" valign="top" charoff="50">Australia</td>
<td align="char" valign="top" char="." charoff="50">409</td>
<td align="char" valign="top" char="." charoff="50">322</td>
<td align="left" valign="top" charoff="50">iPlex</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Mayo Clinic (MAYO)</td>
<td align="left" valign="top" charoff="50">USA</td>
<td align="char" valign="top" char="." charoff="50">106</td>
<td align="char" valign="top" char="." charoff="50">56</td>
<td align="left" valign="top" charoff="50">iPlex</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Milan Breast Cancer Study Group (MBCSG)</td>
<td align="left" valign="top" charoff="50">Italy</td>
<td align="char" valign="top" char="." charoff="50">246</td>
<td align="char" valign="top" char="." charoff="50">132</td>
<td align="left" valign="top" charoff="50">Taqman</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Modifier Study of Quantitative Effects on Disease (ModSQuaD)</td>
<td align="left" valign="top" charoff="50">Czech Republic, Belgium</td>
<td align="char" valign="top" char="." charoff="50">132</td>
<td align="char" valign="top" char="." charoff="50">35</td>
<td align="left" valign="top" charoff="50">Taqman</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> National Cancer Institute (NCI)</td>
<td align="left" valign="top" charoff="50">USA</td>
<td align="char" valign="top" char="." charoff="50">139</td>
<td align="char" valign="top" char="." charoff="50">57</td>
<td align="left" valign="top" charoff="50">Taqman</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> National Israeli Cancer Control Center (NICCC)</td>
<td align="left" valign="top" charoff="50">Israel</td>
<td align="char" valign="top" char="." charoff="50">221</td>
<td align="char" valign="top" char="." charoff="50">129</td>
<td align="left" valign="top" charoff="50">Taqman</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Ontario Cancer Genetics Network (OCGN)</td>
<td align="left" valign="top" charoff="50">Canada</td>
<td align="char" valign="top" char="." charoff="50">180</td>
<td align="char" valign="top" char="." charoff="50">130</td>
<td align="left" valign="top" charoff="50">Taqman</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Odense University Hospital (OUH)</td>
<td align="left" valign="top" charoff="50">Denmark</td>
<td align="char" valign="top" char="." charoff="50">109</td>
<td align="char" valign="top" char="." charoff="50">0</td>
<td align="left" valign="top" charoff="50">Taqman</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Pisa Breast Cancer Study (PBCS)</td>
<td align="left" valign="top" charoff="50">Italy</td>
<td align="char" valign="top" char="." charoff="50">56</td>
<td align="char" valign="top" char="." charoff="50">32</td>
<td align="left" valign="top" charoff="50">Taqman</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Swedish Breast Cancer Study (SWE-BRCA)</td>
<td align="left" valign="top" charoff="50">Sweden</td>
<td align="char" valign="top" char="." charoff="50">427</td>
<td align="char" valign="top" char="." charoff="50">130</td>
<td align="left" valign="top" charoff="50">Taqman</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> University of Pennsylvania (UPENN)</td>
<td align="left" valign="top" charoff="50">USA</td>
<td align="char" valign="top" char="." charoff="50">255</td>
<td align="char" valign="top" char="." charoff="50">121</td>
<td align="left" valign="top" charoff="50">Taqman</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Total</td>
<td align="left" valign="top" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50">6211</td>
<td align="char" valign="top" char="." charoff="50">2902</td>
<td align="left" valign="top" charoff="50"> </td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn id="t1-fn1"><p>Abbreviations: MTHFR, methylene-tetrahydrofolate reductase; PHB, prohibitin; RFLP, restriction fragment length polymorphism.</p>
</fn>
<fn id="t1-fn2"><label>a</label>
<p>Country of the clinic at which carriers are recruited</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="tbl2"><label>Table 2</label>
<caption><title><italic>PHB</italic>
1630 C>T genotype frequencies by (a) disease status and breast cancer hazard ratio estimates; (b) disease status and ovarian cancer hazard ratio estimates</title>
</caption>
<table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col>
<col align="left"></col>
<col align="char" char="("></col>
<col align="char" char="("></col>
<col align="char" char="."></col>
<col align="char" char="."></col>
<col align="char" char="."></col>
</colgroup>
<thead valign="bottom"><tr><th align="left" valign="top" charoff="50"><bold>Gene</bold>
</th>
<th align="left" valign="top" charoff="50"><bold>Genotype</bold>
</th>
<th align="char" valign="top" char="(" charoff="50"><bold>Unaffected</bold>
<italic><bold>n</bold>
</italic>
<bold>(%)</bold>
</th>
<th align="char" valign="top" char="(" charoff="50"><bold>Affected</bold>
<italic><bold>n</bold>
</italic>
<bold>(%)</bold>
</th>
<th align="char" valign="top" char="." charoff="50"><bold>HR</bold>
</th>
<th align="char" valign="top" char="." charoff="50"><bold>95% CI</bold>
</th>
<th align="char" valign="top" char="." charoff="50"><italic><bold>P</bold>
</italic>
<bold>-value</bold>
</th>
</tr>
</thead>
<tbody valign="top"><tr><td colspan="7" align="left" valign="top" charoff="50"><italic>(a)</italic>
<xref ref-type="fn" rid="t2-fn2">a</xref>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>BRCA1</italic>
</td>
<td align="left" valign="top" charoff="50">CC</td>
<td align="char" valign="top" char="(" charoff="50">1443 (69.7)</td>
<td align="char" valign="top" char="(" charoff="50">1388 (68.3)</td>
<td align="char" valign="top" char="." charoff="50">1.00</td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50">CT</td>
<td align="char" valign="top" char="(" charoff="50">575 (27.8)</td>
<td align="char" valign="top" char="(" charoff="50">574 (28.3)</td>
<td align="char" valign="top" char="." charoff="50">1.04</td>
<td align="char" valign="top" char="." charoff="50">0.92–1.18</td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50">TT</td>
<td align="char" valign="top" char="(" charoff="50">52 (2.5)</td>
<td align="char" valign="top" char="(" charoff="50">70 (3.4)</td>
<td align="char" valign="top" char="." charoff="50">1.35</td>
<td align="char" valign="top" char="." charoff="50">0.99–1.84</td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50">2df test</td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50">0.17</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50">Per-Allele</td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50">1.08</td>
<td align="char" valign="top" char="." charoff="50">0.97–1.21</td>
<td align="char" valign="top" char="." charoff="50">0.15</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>BRCA2</italic>
</td>
<td align="left" valign="top" charoff="50">CC</td>
<td align="char" valign="top" char="(" charoff="50">672 (67.9)</td>
<td align="char" valign="top" char="(" charoff="50">714 (64.7)</td>
<td align="char" valign="top" char="." charoff="50">1.00</td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50">CT</td>
<td align="char" valign="top" char="(" charoff="50">293 (29.9)</td>
<td align="char" valign="top" char="(" charoff="50">354 (32.1)</td>
<td align="char" valign="top" char="." charoff="50">1.15</td>
<td align="char" valign="top" char="." charoff="50">0.96–1.37</td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50">TT</td>
<td align="char" valign="top" char="(" charoff="50">25 (2.5)</td>
<td align="char" valign="top" char="(" charoff="50">35 (3.2)</td>
<td align="char" valign="top" char="." charoff="50">1.13</td>
<td align="char" valign="top" char="." charoff="50">0.70–1.82</td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50">2df test</td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50">0.29</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50">Per-Allele</td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50">1.12</td>
<td align="char" valign="top" char="." charoff="50">0.96–1.30</td>
<td align="char" valign="top" char="." charoff="50">0.14</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td colspan="7" align="char" valign="top" char="." charoff="50"><italic>(b)</italic>
<xref ref-type="fn" rid="t2-fn2">b</xref>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>BRCA1</italic>
</td>
<td align="left" valign="top" charoff="50">CC</td>
<td align="char" valign="top" char="(" charoff="50">2368 (68.9)</td>
<td align="char" valign="top" char="(" charoff="50">463 (69.6)</td>
<td align="char" valign="top" char="." charoff="50">1.00</td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50">CT</td>
<td align="char" valign="top" char="(" charoff="50">972 (28.3)</td>
<td align="char" valign="top" char="(" charoff="50">177 (26.6)</td>
<td align="char" valign="top" char="." charoff="50">0.93</td>
<td align="char" valign="top" char="." charoff="50">0.83–1.06</td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50">TT</td>
<td align="char" valign="top" char="(" charoff="50">97 (2.8)</td>
<td align="char" valign="top" char="(" charoff="50">25 (3.8)</td>
<td align="char" valign="top" char="." charoff="50">1.49</td>
<td align="char" valign="top" char="." charoff="50">0.91–2.45</td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50">2df test</td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50">0.18</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50">Per-Allele</td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50">1.03</td>
<td align="char" valign="top" char="." charoff="50">0.87–1.23</td>
<td align="char" valign="top" char="." charoff="50">0.73</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>BRCA2</italic>
</td>
<td align="left" valign="top" charoff="50">CC</td>
<td align="char" valign="top" char="(" charoff="50">1274 (66.0)</td>
<td align="char" valign="top" char="(" charoff="50">112 (68.3)</td>
<td align="char" valign="top" char="." charoff="50">1.00</td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50">CT</td>
<td align="char" valign="top" char="(" charoff="50">603 (31.3)</td>
<td align="char" valign="top" char="(" charoff="50">44 (26.8)</td>
<td align="char" valign="top" char="." charoff="50">0.80</td>
<td align="char" valign="top" char="." charoff="50">0.55–1.15</td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50">TT</td>
<td align="char" valign="top" char="(" charoff="50">52 (2.7)</td>
<td align="char" valign="top" char="(" charoff="50">8 (4.9)</td>
<td align="char" valign="top" char="." charoff="50">1.63</td>
<td align="char" valign="top" char="." charoff="50">0.67–3.99</td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50">2df test</td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50">0.21</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50">Per-Allele</td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50">0.96</td>
<td align="char" valign="top" char="." charoff="50">0.67–1.38</td>
<td align="char" valign="top" char="." charoff="50">0.84</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn id="t2-fn1"><p>Abbreviation: PHB, prohibitin.</p>
</fn>
<fn id="t2-fn2"><label>a</label>
<p>Diagnosed with breast cancer.</p>
</fn>
<fn id="t2-fn3"><label>b</label>
<p>Diagnosed with ovarian cancer.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="tbl3"><label>Table 3</label>
<caption><title><italic>PHB</italic>
1630 C>T and <italic>MTHFR</italic>
677 C>T genotype frequencies by disease status, <italic>BRCA1/2</italic>
mutation and, breast and ovarian cancer hazard ratio estimates in competing risk analysis</title>
</caption>
<table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col>
<col align="char" char="("></col>
<col align="char" char="("></col>
<col align="char" char="."></col>
<col align="char" char="."></col>
<col align="char" char="."></col>
<col align="char" char="("></col>
<col align="char" char="."></col>
<col align="char" char="."></col>
<col align="char" char="."></col>
</colgroup>
<thead valign="bottom"><tr><th align="left" valign="top" charoff="50"> </th>
<th align="center" valign="top" char="(" charoff="50"><bold>Unaffected</bold>
<italic><bold>n</bold>
</italic>
<bold>(%)</bold>
</th>
<th align="center" valign="top" char="(" charoff="50"><bold>Ovarian cancer</bold>
<italic><bold>n</bold>
</italic>
<bold>(%)</bold>
</th>
<th align="center" valign="top" char="." charoff="50"><bold>HR</bold>
</th>
<th align="center" valign="top" char="." charoff="50"><bold>95% CI</bold>
</th>
<th align="center" valign="top" char="." charoff="50"><italic><bold>P</bold>
</italic>
<bold>-value</bold>
</th>
<th align="center" valign="top" char="(" charoff="50"><bold>Breast cancer</bold>
<italic><bold>n</bold>
</italic>
<bold>(%)</bold>
</th>
<th align="center" valign="top" char="." charoff="50"><bold>HR</bold>
</th>
<th align="center" valign="top" char="." charoff="50"><bold>95% CI</bold>
</th>
<th align="center" valign="top" char="." charoff="50"><italic><bold>P</bold>
</italic>
<bold>-value</bold>
</th>
</tr>
</thead>
<tbody valign="top"><tr><td colspan="10" align="left" valign="top" charoff="50"><italic>PHB</italic>
1630 C>T</td>
</tr>
<tr><td align="left" valign="top" charoff="50">BRCA1</td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> CC</td>
<td align="char" valign="top" char="(" charoff="50">1155 (69.8)</td>
<td align="char" valign="top" char="(" charoff="50">334 (69.2)</td>
<td align="char" valign="top" char="." charoff="50">1.00</td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50">1342 (68.3)</td>
<td align="char" valign="top" char="." charoff="50">1.00</td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> CT</td>
<td align="char" valign="top" char="(" charoff="50">465 (28.1)</td>
<td align="char" valign="top" char="(" charoff="50">130 (26.9)</td>
<td align="char" valign="top" char="." charoff="50">0.99</td>
<td align="char" valign="top" char="." charoff="50">0.78-1.25</td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50">554 (28.2)</td>
<td align="char" valign="top" char="." charoff="50">1.04</td>
<td align="char" valign="top" char="." charoff="50">0.92-1.19</td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> TT</td>
<td align="char" valign="top" char="(" charoff="50">34 (2.1)</td>
<td align="char" valign="top" char="(" charoff="50">19 (3.9)</td>
<td align="char" valign="top" char="." charoff="50"><bold>2.16</bold>
</td>
<td align="char" valign="top" char="." charoff="50"><bold>1.24–3.76</bold>
</td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50">69 (3.5)</td>
<td align="char" valign="top" char="." charoff="50"><bold>1.50</bold>
</td>
<td align="char" valign="top" char="." charoff="50"><bold>1.10–2.04</bold>
</td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Per-allele</td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50">1.16</td>
<td align="char" valign="top" char="." charoff="50">0.93–1.41</td>
<td align="char" valign="top" char="." charoff="50">0.19</td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50">1.11</td>
<td align="char" valign="top" char="." charoff="50">0.99–1.23</td>
<td align="char" valign="top" char="." charoff="50">0.06</td>
</tr>
<tr><td colspan="10" align="left" valign="top" charoff="50">BRCA1 excluding IHCC</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> CC</td>
<td align="char" valign="top" char="(" charoff="50">933 (67.9)</td>
<td align="char" valign="top" char="(" charoff="50">233 (65.8)</td>
<td align="char" valign="top" char="." charoff="50">1.00</td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50">1136 (67.7)</td>
<td align="char" valign="top" char="." charoff="50">1.00</td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> CT</td>
<td align="char" valign="top" char="(" charoff="50">412 (30.0)</td>
<td align="char" valign="top" char="(" charoff="50">103 (29.1)</td>
<td align="char" valign="top" char="." charoff="50">0.98</td>
<td align="char" valign="top" char="." charoff="50">0.75–1.29</td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50">478 (28.5)</td>
<td align="char" valign="top" char="." charoff="50">0.99</td>
<td align="char" valign="top" char="." charoff="50">0.86–1.14</td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> TT</td>
<td align="char" valign="top" char="(" charoff="50">29 (2.1)</td>
<td align="char" valign="top" char="(" charoff="50">18 (5.1)</td>
<td align="char" valign="top" char="." charoff="50"><bold>2.32</bold>
</td>
<td align="char" valign="top" char="." charoff="50"><bold>1.34–4.05</bold>
</td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50">64 (3.8)</td>
<td align="char" valign="top" char="." charoff="50"><bold>1.43</bold>
</td>
<td align="char" valign="top" char="." charoff="50"><bold>1.05–1.98</bold>
</td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Per-allele</td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50">1.18</td>
<td align="char" valign="top" char="." charoff="50">0.94–1.48</td>
<td align="char" valign="top" char="." charoff="50">0.15</td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50">1.07</td>
<td align="char" valign="top" char="." charoff="50">0.95–1.20</td>
<td align="char" valign="top" char="." charoff="50">0.27</td>
</tr>
<tr><td align="left" valign="top" charoff="50">BRCA2</td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> CC</td>
<td align="char" valign="top" char="(" charoff="50">616 (67.1)</td>
<td align="char" valign="top" char="(" charoff="50">83 (71.6)</td>
<td align="char" valign="top" char="." charoff="50">1.00</td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50">687 (64.9)</td>
<td align="char" valign="top" char="." charoff="50">1.00</td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> CT</td>
<td align="char" valign="top" char="(" charoff="50">282 (30.7)</td>
<td align="char" valign="top" char="(" charoff="50">28 (24.1)</td>
<td align="char" valign="top" char="." charoff="50">0.69</td>
<td align="char" valign="top" char="." charoff="50">0.45–1.07</td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50">337 (31.8)</td>
<td align="char" valign="top" char="." charoff="50">1.08</td>
<td align="char" valign="top" char="." charoff="50">0.90–1.30</td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> TT</td>
<td align="char" valign="top" char="(" charoff="50">20 (2.2)</td>
<td align="char" valign="top" char="(" charoff="50">5 (4.3)</td>
<td align="char" valign="top" char="." charoff="50">1.46</td>
<td align="char" valign="top" char="." charoff="50">0.44–4.81</td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50">35 (3.3)</td>
<td align="char" valign="top" char="." charoff="50">1.24</td>
<td align="char" valign="top" char="." charoff="50">0.81–1.89</td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Per-Allele</td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50">0.86</td>
<td align="char" valign="top" char="." charoff="50">0.53–1.39</td>
<td align="char" valign="top" char="." charoff="50">0.54</td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50">1.09</td>
<td align="char" valign="top" char="." charoff="50">0.94–1.27</td>
<td align="char" valign="top" char="." charoff="50">0.23</td>
</tr>
<tr><td colspan="10" align="left" valign="top" charoff="50"> </td>
</tr>
<tr><td colspan="10" align="left" valign="top" charoff="50"><italic>MTHFR</italic>
677 C>T</td>
</tr>
<tr><td colspan="10" align="left" valign="top" charoff="50">BRCA1</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> CC</td>
<td align="char" valign="top" char="(" charoff="50">976 (43.3)</td>
<td align="char" valign="top" char="(" charoff="50">349 (43.1)</td>
<td align="char" valign="top" char="." charoff="50">1.00</td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50">1344 (42.7)</td>
<td align="char" valign="top" char="." charoff="50">1.00</td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> CT</td>
<td align="char" valign="top" char="(" charoff="50">1000 (44.4)</td>
<td align="char" valign="top" char="(" charoff="50">361 (44.6)</td>
<td align="char" valign="top" char="." charoff="50">0.95</td>
<td align="char" valign="top" char="." charoff="50">0.79–1.13</td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50">1425 (45.3)</td>
<td align="char" valign="top" char="." charoff="50">0.99</td>
<td align="char" valign="top" char="." charoff="50">0.89–1.09</td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> TT</td>
<td align="char" valign="top" char="(" charoff="50">279 (12.4)</td>
<td align="char" valign="top" char="(" charoff="50">99 (12.2)</td>
<td align="char" valign="top" char="." charoff="50">0.93</td>
<td align="char" valign="top" char="." charoff="50">0.72–1.21</td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50">378 (12.0)</td>
<td align="char" valign="top" char="." charoff="50">0.96</td>
<td align="char" valign="top" char="." charoff="50">0.82–1.13</td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Per-allele</td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50">0.96</td>
<td align="char" valign="top" char="." charoff="50">0.85–1.08</td>
<td align="char" valign="top" char="." charoff="50">0.51</td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50">0.98</td>
<td align="char" valign="top" char="." charoff="50">0.99–1.06</td>
<td align="char" valign="top" char="." charoff="50">0.63</td>
</tr>
<tr><td align="left" valign="top" charoff="50">BRCA2</td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> CC</td>
<td align="char" valign="top" char="(" charoff="50">471 (43.0)</td>
<td align="char" valign="top" char="(" charoff="50">74 (42.1)</td>
<td align="char" valign="top" char="." charoff="50">1.00</td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50">688 (42.2)</td>
<td align="char" valign="top" char="." charoff="50">1.00</td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> CT</td>
<td align="char" valign="top" char="(" charoff="50">481 (43.9)</td>
<td align="char" valign="top" char="(" charoff="50">85 (48.3)</td>
<td align="char" valign="top" char="." charoff="50">1.09</td>
<td align="char" valign="top" char="." charoff="50">0.76–1.57</td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50">741 (45.4)</td>
<td align="char" valign="top" char="." charoff="50">1.05</td>
<td align="char" valign="top" char="." charoff="50">0.90–1.23</td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> TT</td>
<td align="char" valign="top" char="(" charoff="50">143 (13.1)</td>
<td align="char" valign="top" char="(" charoff="50">17 (9.7)</td>
<td align="char" valign="top" char="." charoff="50">0.74</td>
<td align="char" valign="top" char="." charoff="50">0.41–1.34</td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50">202 (12.4)</td>
<td align="char" valign="top" char="." charoff="50">0.95</td>
<td align="char" valign="top" char="." charoff="50">0.76–1.20</td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Per-allele</td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50">0.93</td>
<td align="char" valign="top" char="." charoff="50">0.72–1.20</td>
<td align="char" valign="top" char="." charoff="50">0.57</td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50">1.00</td>
<td align="char" valign="top" char="." charoff="50">0.90–1.11</td>
<td align="char" valign="top" char="." charoff="50">0.98</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn id="t3-fn1"><p>Abbreviations: MTHFR, methylene-tetrahydrofolate reductase; PHB, prohibitin. Significant results are marked in bold.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="tbl4"><label>Table 4</label>
<caption><title><italic>MTHF</italic>
R 677 C>T genotype frequencies by (a) disease status and breast cancer hazard ratio estimates; (b) disease status and ovarian cancer hazard ratio estimates</title>
</caption>
<table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col>
<col align="left"></col>
<col align="char" char="("></col>
<col align="char" char="("></col>
<col align="char" char="."></col>
<col align="char" char="."></col>
<col align="char" char="."></col>
</colgroup>
<thead valign="bottom"><tr><th align="left" valign="top" charoff="50"><bold>Gene</bold>
</th>
<th align="center" valign="top" charoff="50"><bold>Genotype</bold>
</th>
<th align="center" valign="top" char="(" charoff="50"><bold>Unaffected</bold>
<italic><bold>n</bold>
</italic>
<bold>(%)</bold>
</th>
<th align="center" valign="top" char="(" charoff="50"><bold>Affected</bold>
<italic><bold>n</bold>
</italic>
<bold>(%)</bold>
</th>
<th align="center" valign="top" char="." charoff="50"><bold>HR</bold>
</th>
<th align="center" valign="top" char="." charoff="50"><bold>95% CI</bold>
</th>
<th align="center" valign="top" char="." charoff="50"><italic><bold>P</bold>
</italic>
<bold>-value</bold>
</th>
</tr>
</thead>
<tbody valign="top"><tr><td colspan="7" align="left" valign="top" charoff="50"><italic>(a)</italic>
<xref ref-type="fn" rid="t4-fn2">a</xref>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>BRCA1</italic>
</td>
<td align="left" valign="top" charoff="50">CC</td>
<td align="char" valign="top" char="(" charoff="50">1281 (43.3)</td>
<td align="char" valign="top" char="(" charoff="50">1388 (42.7)</td>
<td align="char" valign="top" char="." charoff="50">1.00</td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50">CT</td>
<td align="char" valign="top" char="(" charoff="50">1313 (44.3)</td>
<td align="char" valign="top" char="(" charoff="50">1473 (45.3)</td>
<td align="char" valign="top" char="." charoff="50">1.00</td>
<td align="char" valign="top" char="." charoff="50">0.90–1.10</td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50">TT</td>
<td align="char" valign="top" char="(" charoff="50">367 (12.4)</td>
<td align="char" valign="top" char="(" charoff="50">389 (12.0)</td>
<td align="char" valign="top" char="." charoff="50">0.96</td>
<td align="char" valign="top" char="." charoff="50">0.82–1.12</td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50">2 df test</td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50">0.84</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50">Per-Allele</td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50">0.98</td>
<td align="char" valign="top" char="." charoff="50">0.92–1.05</td>
<td align="char" valign="top" char="." charoff="50">0.64</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>BRCA2</italic>
</td>
<td align="left" valign="top" charoff="50">CC</td>
<td align="char" valign="top" char="(" charoff="50">530 (43.3)</td>
<td align="char" valign="top" char="(" charoff="50">703 (41.9)</td>
<td align="char" valign="top" char="." charoff="50">1.00</td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50">CT</td>
<td align="char" valign="top" char="(" charoff="50">542 (44.3)</td>
<td align="char" valign="top" char="(" charoff="50">765 (45.6)</td>
<td align="char" valign="top" char="." charoff="50">1.05</td>
<td align="char" valign="top" char="." charoff="50">0.91–1.22</td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50">TT</td>
<td align="char" valign="top" char="(" charoff="50">152 (12.4)</td>
<td align="char" valign="top" char="(" charoff="50">210 (12.5)</td>
<td align="char" valign="top" char="." charoff="50">1.02</td>
<td align="char" valign="top" char="." charoff="50">0.82–1.27</td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50">2 df test</td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50">0.78</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50">Per-Allele</td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50">1.02</td>
<td align="char" valign="top" char="." charoff="50">0.93–1.13</td>
<td align="char" valign="top" char="." charoff="50">0.66</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td colspan="7" align="left" valign="top" charoff="50"><italic>(b)</italic>
<xref ref-type="fn" rid="t4-fn3">b</xref>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>BRCA1</italic>
</td>
<td align="left" valign="top" charoff="50">CC</td>
<td align="char" valign="top" char="(" charoff="50">2190 (43.3)</td>
<td align="char" valign="top" char="(" charoff="50">479 (42.6)</td>
<td align="char" valign="top" char="." charoff="50">1.00</td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50">CT</td>
<td align="char" valign="top" char="(" charoff="50">2259 (44.7)</td>
<td align="char" valign="top" char="(" charoff="50">527 (45.8)</td>
<td align="char" valign="top" char="." charoff="50">1.01</td>
<td align="char" valign="top" char="." charoff="50">0.88–1.16</td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50">TT</td>
<td align="char" valign="top" char="(" charoff="50">610 (12.1)</td>
<td align="char" valign="top" char="(" charoff="50">146 (12.7)</td>
<td align="char" valign="top" char="." charoff="50">1.04</td>
<td align="char" valign="top" char="." charoff="50">0.84–1.28</td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50">2 df test</td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50">0.88</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50">Per-Allele</td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50">1.02</td>
<td align="char" valign="top" char="." charoff="50">0.92–1.12</td>
<td align="char" valign="top" char="." charoff="50">0.73</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>BRCA2</italic>
</td>
<td align="left" valign="top" charoff="50">CC</td>
<td align="char" valign="top" char="(" charoff="50">1132 (42.7)</td>
<td align="char" valign="top" char="(" charoff="50">101 (40.7)</td>
<td align="char" valign="top" char="." charoff="50">1.00</td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50">CT</td>
<td align="char" valign="top" char="(" charoff="50">1193 (44.9)</td>
<td align="char" valign="top" char="(" charoff="50">114 (46.0)</td>
<td align="char" valign="top" char="." charoff="50">1.05</td>
<td align="char" valign="top" char="." charoff="50">0.75–1.41</td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50">TT</td>
<td align="char" valign="top" char="(" charoff="50">329 (12.4)</td>
<td align="char" valign="top" char="(" charoff="50">33 (13.3)</td>
<td align="char" valign="top" char="." charoff="50">1.14</td>
<td align="char" valign="top" char="." charoff="50">0.74–1.76</td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50">2 df test</td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50">0.84</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="left" valign="top" charoff="50">Per-Allele</td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50">1.06</td>
<td align="char" valign="top" char="." charoff="50">0.87–1.30</td>
<td align="char" valign="top" char="." charoff="50">0.57</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn id="t4-fn1"><p>Abbreviation: MTHFR, methylene-tetrahydrofolate reductase.</p>
</fn>
<fn id="t4-fn2"><label>a</label>
<p>Diagnosed with breast cancer.</p>
</fn>
<fn id="t4-fn3"><label>b</label>
<p>Diagnosed with ovarian cancer.</p>
</fn>
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