CA-125 can be part of the tumour evaluation criteria in ovarian cancer trials: experience of the GCIG CALYPSO trial
Identifieur interne : 000077 ( Pmc/Curation ); précédent : 000076; suivant : 000078CA-125 can be part of the tumour evaluation criteria in ovarian cancer trials: experience of the GCIG CALYPSO trial
Auteurs : J. Alexandre [France] ; C. Brown [Australie] ; D. Coeffic [France] ; N. Raban [France] ; J. Pfisterer [Allemagne] ; J. M Enp [Finlande] ; H. Chalchal ; B. Fitzharris [Nouvelle-Zélande] ; B. Volgger [Autriche] ; I. Vergote [Belgique] ; C. Pisano [Italie] ; A. Ferrero [Italie] ; E. Pujade-Lauraine [France]Source :
- British Journal of Cancer [ 0007-0920 ] ; 2012.
Abstract
CA-125 as a tumour progression criterion in relapsing ovarian cancer (ROC) trials remains controversial. CALYPSO is a large randomised trial incorporating CA-125 (GCIG criteria) and symptomatic deterioration in addition to Response Evaluation Criteria in Solid Tumours (RECIST) criteria (radiological) to determine progression.
In all, 976 patients with platinum-sensitive ROC were randomised to carboplatin–paclitaxel (C-P) or carboplatin-pegylated liposomal doxorubicin (C-PLD). CT-scan and CA-125 were performed every 3 months until progression.
In all, 832 patients (85%) progressed, with 60% experiencing a first radiological progression, 10% symptomatic progression, and 28% CA-125 progression without evidence of radiological or symptomatic progression. The benefit of C-PLD
CA-125 and radiological tests performed similarly in determining progression with C-PLD or C-P. Additional follow-up with CA-125 measurements was not associated with overtreatment.
Url:
DOI: 10.1038/bjc.2011.593
PubMed: 22240800
PubMed Central: 3322951
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H. Chalchal<affiliation><nlm:aff id="aff7"><institution>Department of Medicine, University of Saskatchewan. Allan Blair Cancer Centre</institution>
, Regina,<country>Saskatchewan</country>
</nlm:aff>
<wicri:noCountry code="nlm country">Saskatchewan</wicri:noCountry>
</affiliation>
Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">CA-125 can be part of the tumour evaluation criteria in ovarian cancer trials: experience of the GCIG CALYPSO trial</title>
<author><name sortKey="Alexandre, J" sort="Alexandre, J" uniqKey="Alexandre J" first="J" last="Alexandre">J. Alexandre</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Département d'Oncologie Médicale, Université Paris Descartes, AP-HP, Hôpitaux Universitaires Paris Centre</institution>
, site Hôtel-Dieu, Paris,<country>France</country>
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<author><name sortKey="Brown, C" sort="Brown, C" uniqKey="Brown C" first="C" last="Brown">C. Brown</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>NHMRC Clinical Trials Centre</institution>
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</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Coeffic, D" sort="Coeffic, D" uniqKey="Coeffic D" first="D" last="Coeffic">D. Coeffic</name>
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, Paris,<country>France</country>
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<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Raban, N" sort="Raban, N" uniqKey="Raban N" first="N" last="Raban">N. Raban</name>
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, Poitiers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Pfisterer, J" sort="Pfisterer, J" uniqKey="Pfisterer J" first="J" last="Pfisterer">J. Pfisterer</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Department of Gynecology, Staedtisches Klinikum Solingen</institution>
, Solingen,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="M Enp, J" sort="M Enp, J" uniqKey="M Enp J" first="J" last="M Enp">J. M Enp</name>
<affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Department of Obstetrics and Gynecology, University of Tampere and Tampere University Hospital</institution>
, Tampere,<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Chalchal, H" sort="Chalchal, H" uniqKey="Chalchal H" first="H" last="Chalchal">H. Chalchal</name>
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, Regina,<country>Saskatchewan</country>
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<wicri:noCountry code="nlm country">Saskatchewan</wicri:noCountry>
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<affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Christchurch Hospital</institution>
, Christchurch,<country>New Zealand</country>
</nlm:aff>
<country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author><name sortKey="Volgger, B" sort="Volgger, B" uniqKey="Volgger B" first="B" last="Volgger">B. Volgger</name>
<affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Department of Obstetrics and Gynecology, University Hospital Innsbruck</institution>
, Innsbruck,<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Vergote, I" sort="Vergote, I" uniqKey="Vergote I" first="I" last="Vergote">I. Vergote</name>
<affiliation wicri:level="1"><nlm:aff id="aff10"><institution>University Hospital Leuven, Leuven Cancer Institute and Department of Gynaecological Oncology</institution>
, Leuven,<country>Belgium</country>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author><name sortKey="Pisano, C" sort="Pisano, C" uniqKey="Pisano C" first="C" last="Pisano">C. Pisano</name>
<affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Division of Medical Oncology, Uro-Gynecological Department, National Cancer Institute</institution>
, Naples,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author><name sortKey="Ferrero, A" sort="Ferrero, A" uniqKey="Ferrero A" first="A" last="Ferrero">A. Ferrero</name>
<affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Academic Division of Gynecologic Oncology, Mauriziano Hospital</institution>
, Torino,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pujade Lauraine, E" sort="Pujade Lauraine, E" uniqKey="Pujade Lauraine E" first="E" last="Pujade-Lauraine">E. Pujade-Lauraine</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Département d'Oncologie Médicale, Université Paris Descartes, AP-HP, Hôpitaux Universitaires Paris Centre</institution>
, site Hôtel-Dieu, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<series><title level="j">British Journal of Cancer</title>
<idno type="ISSN">0007-0920</idno>
<idno type="eISSN">1532-1827</idno>
<imprint><date when="2012">2012</date>
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<front><div type="abstract" xml:lang="en"><sec><title>Background:</title>
<p>CA-125 as a tumour progression criterion in relapsing ovarian cancer (ROC) trials remains controversial. CALYPSO is a large randomised trial incorporating CA-125 (GCIG criteria) and symptomatic deterioration in addition to Response Evaluation Criteria in Solid Tumours (RECIST) criteria (radiological) to determine progression.</p>
</sec>
<sec><title>Methods:</title>
<p>In all, 976 patients with platinum-sensitive ROC were randomised to carboplatin–paclitaxel (C-P) or carboplatin-pegylated liposomal doxorubicin (C-PLD). CT-scan and CA-125 were performed every 3 months until progression.</p>
</sec>
<sec><title>Results:</title>
<p>In all, 832 patients (85%) progressed, with 60% experiencing a first radiological progression, 10% symptomatic progression, and 28% CA-125 progression without evidence of radiological or symptomatic progression. The benefit of C-PLD <italic>vs</italic>
C-P in progression-free survival was not influenced by type of first progression (hazard ratio 0.85 (95% confidence interval (CI): 0.66–1.10) and 0.84 (95% CI: 0.72–0.98) for CA-125 and RECIST, respectively). In patients with CA-125 first progression who subsequently progressed radiologically, a delay of 2.3 months was observed between the two progression types. After CA-125 first progression, median time to new treatment was 2.0 months. In all, 81%of the patients with CA-125 or radiological first progression and 60% with symptomatic first progression received subsequent treatment.</p>
</sec>
<sec><title>Conclusion:</title>
<p>CA-125 and radiological tests performed similarly in determining progression with C-PLD or C-P. Additional follow-up with CA-125 measurements was not associated with overtreatment.</p>
</sec>
</div>
</front>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Br J Cancer</journal-id>
<journal-id journal-id-type="iso-abbrev">Br. J. Cancer</journal-id>
<journal-title-group><journal-title>British Journal of Cancer</journal-title>
</journal-title-group>
<issn pub-type="ppub">0007-0920</issn>
<issn pub-type="epub">1532-1827</issn>
<publisher><publisher-name>Nature Publishing Group</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">22240800</article-id>
<article-id pub-id-type="pmc">3322951</article-id>
<article-id pub-id-type="pii">bjc2011593</article-id>
<article-id pub-id-type="doi">10.1038/bjc.2011.593</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Clinical Studies</subject>
</subj-group>
</article-categories>
<title-group><article-title>CA-125 can be part of the tumour evaluation criteria in ovarian cancer trials: experience of the GCIG CALYPSO trial</article-title>
<alt-title alt-title-type="running">CALYPSO experience with CA-125</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Alexandre</surname>
<given-names>J</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="corresp" rid="caf1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Brown</surname>
<given-names>C</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Coeffic</surname>
<given-names>D</given-names>
</name>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Raban</surname>
<given-names>N</given-names>
</name>
<xref ref-type="aff" rid="aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pfisterer</surname>
<given-names>J</given-names>
</name>
<xref ref-type="aff" rid="aff5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mäenpää</surname>
<given-names>J</given-names>
</name>
<xref ref-type="aff" rid="aff6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chalchal</surname>
<given-names>H</given-names>
</name>
<xref ref-type="aff" rid="aff7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fitzharris</surname>
<given-names>B</given-names>
</name>
<xref ref-type="aff" rid="aff8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Volgger</surname>
<given-names>B</given-names>
</name>
<xref ref-type="aff" rid="aff9">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vergote</surname>
<given-names>I</given-names>
</name>
<xref ref-type="aff" rid="aff10">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pisano</surname>
<given-names>C</given-names>
</name>
<xref ref-type="aff" rid="aff11">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ferrero</surname>
<given-names>A</given-names>
</name>
<xref ref-type="aff" rid="aff12">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pujade-Lauraine</surname>
<given-names>E</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<aff id="aff1"><label>1</label>
<institution>Département d'Oncologie Médicale, Université Paris Descartes, AP-HP, Hôpitaux Universitaires Paris Centre</institution>
, site Hôtel-Dieu, Paris,<country>France</country>
</aff>
<aff id="aff2"><label>2</label>
<institution>NHMRC Clinical Trials Centre</institution>
, Sydney,<country>Australia</country>
</aff>
<aff id="aff3"><label>3</label>
<institution>Medical Oncology Department, Hôpital des Diaconesses</institution>
, Paris,<country>France</country>
</aff>
<aff id="aff4"><label>4</label>
<institution>Department of Medical Oncology, University Hospital of Milétrie</institution>
, Poitiers,<country>France</country>
</aff>
<aff id="aff5"><label>5</label>
<institution>Department of Gynecology, Staedtisches Klinikum Solingen</institution>
, Solingen,<country>Germany</country>
</aff>
<aff id="aff6"><label>6</label>
<institution>Department of Obstetrics and Gynecology, University of Tampere and Tampere University Hospital</institution>
, Tampere,<country>Finland</country>
</aff>
<aff id="aff7"><label>7</label>
<institution>Department of Medicine, University of Saskatchewan. Allan Blair Cancer Centre</institution>
, Regina,<country>Saskatchewan</country>
</aff>
<aff id="aff8"><label>8</label>
<institution>Christchurch Hospital</institution>
, Christchurch,<country>New Zealand</country>
</aff>
<aff id="aff9"><label>9</label>
<institution>Department of Obstetrics and Gynecology, University Hospital Innsbruck</institution>
, Innsbruck,<country>Austria</country>
</aff>
<aff id="aff10"><label>10</label>
<institution>University Hospital Leuven, Leuven Cancer Institute and Department of Gynaecological Oncology</institution>
, Leuven,<country>Belgium</country>
</aff>
<aff id="aff11"><label>11</label>
<institution>Division of Medical Oncology, Uro-Gynecological Department, National Cancer Institute</institution>
, Naples,<country>Italy</country>
</aff>
<aff id="aff12"><label>12</label>
<institution>Academic Division of Gynecologic Oncology, Mauriziano Hospital</institution>
, Torino,<country>Italy</country>
</aff>
</contrib-group>
<author-notes><corresp id="caf1"><label>*</label>
E-mail: <email>jerome.alexandre@htd.aphp.fr</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><day>14</day>
<month>02</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="epub"><day>12</day>
<month>01</month>
<year>2012</year>
</pub-date>
<volume>106</volume>
<issue>4</issue>
<fpage>633</fpage>
<lpage>637</lpage>
<history><date date-type="received"><day>05</day>
<month>09</month>
<year>2011</year>
</date>
<date date-type="rev-recd"><day>22</day>
<month>11</month>
<year>2011</year>
</date>
<date date-type="accepted"><day>16</day>
<month>12</month>
<year>2011</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2012 Cancer Research UK</copyright-statement>
<copyright-year>2012</copyright-year>
<copyright-holder>Cancer Research UK</copyright-holder>
</permissions>
<abstract><sec><title>Background:</title>
<p>CA-125 as a tumour progression criterion in relapsing ovarian cancer (ROC) trials remains controversial. CALYPSO is a large randomised trial incorporating CA-125 (GCIG criteria) and symptomatic deterioration in addition to Response Evaluation Criteria in Solid Tumours (RECIST) criteria (radiological) to determine progression.</p>
</sec>
<sec><title>Methods:</title>
<p>In all, 976 patients with platinum-sensitive ROC were randomised to carboplatin–paclitaxel (C-P) or carboplatin-pegylated liposomal doxorubicin (C-PLD). CT-scan and CA-125 were performed every 3 months until progression.</p>
</sec>
<sec><title>Results:</title>
<p>In all, 832 patients (85%) progressed, with 60% experiencing a first radiological progression, 10% symptomatic progression, and 28% CA-125 progression without evidence of radiological or symptomatic progression. The benefit of C-PLD <italic>vs</italic>
C-P in progression-free survival was not influenced by type of first progression (hazard ratio 0.85 (95% confidence interval (CI): 0.66–1.10) and 0.84 (95% CI: 0.72–0.98) for CA-125 and RECIST, respectively). In patients with CA-125 first progression who subsequently progressed radiologically, a delay of 2.3 months was observed between the two progression types. After CA-125 first progression, median time to new treatment was 2.0 months. In all, 81%of the patients with CA-125 or radiological first progression and 60% with symptomatic first progression received subsequent treatment.</p>
</sec>
<sec><title>Conclusion:</title>
<p>CA-125 and radiological tests performed similarly in determining progression with C-PLD or C-P. Additional follow-up with CA-125 measurements was not associated with overtreatment.</p>
</sec>
</abstract>
<kwd-group><kwd>ovarian cancer</kwd>
<kwd>CA-125</kwd>
<kwd>pegylated liposomal doxorubicin</kwd>
<kwd>carboplatin</kwd>
<kwd>paclitaxel</kwd>
<kwd>radiological</kwd>
</kwd-group>
</article-meta>
</front>
<floats-group><fig id="fig1"><label>Figure 1</label>
<caption><p>Cumulative incidence of type of progression.</p>
</caption>
<graphic xlink:href="bjc2011593f1"></graphic>
</fig>
<fig id="fig2"><label>Figure 2</label>
<caption><p>Differences between C-PLD and C-P arms according to type of first progression. <sup>*</sup>
Indicates time to radiological progression post-CA-125 elevation including time to RECIST failure for those patients without prior CA-125 elevation. Abbreviations: C-P=carboplatin–paclitaxel; C-PLD=carboplatin-pegylated liposomal doxorubicin; RECIST=response evaluation criteria in solid tumours.</p>
</caption>
<graphic xlink:href="bjc2011593f2"></graphic>
</fig>
<table-wrap id="tbl1"><label>Table 1</label>
<caption><title>Type of first progression</title>
</caption>
<table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col>
<col align="char" char="("></col>
<col align="char" char="("></col>
<col align="char" char="("></col>
</colgroup>
<thead valign="bottom"><tr><th align="left" valign="top" charoff="50"> </th>
<th colspan="3" align="center" valign="top" char="(" charoff="50"><bold>Number of patients (%)</bold>
<hr></hr>
</th>
</tr>
<tr><th align="left" valign="top" charoff="50"><bold>Type of first progression</bold>
</th>
<th align="center" valign="top" char="(" charoff="50"><bold>Early progression (<italic>n</italic>
=146)</bold>
</th>
<th align="center" valign="top" char="(" charoff="50"><bold>Other progressions (<italic>n</italic>
=686)</bold>
</th>
<th align="center" valign="top" char="(" charoff="50"><bold>All progressions (<italic>n</italic>
=832)</bold>
</th>
</tr>
</thead>
<tbody valign="top"><tr><td align="left" valign="top" charoff="50">RECIST<xref ref-type="fn" rid="t1-fn2">a</xref>
</td>
<td align="char" valign="top" char="(" charoff="50">88 (61)</td>
<td align="char" valign="top" char="(" charoff="50">414 (60)</td>
<td align="char" valign="top" char="(" charoff="50">502 (60)</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Isolated CA-125 doubling (GCIG)</td>
<td align="char" valign="top" char="(" charoff="50">28 (19)</td>
<td align="char" valign="top" char="(" charoff="50">204 (30)</td>
<td align="char" valign="top" char="(" charoff="50">232 (28)</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Symptomatic<xref ref-type="fn" rid="t1-fn3">b</xref>
</td>
<td align="char" valign="top" char="(" charoff="50">29 (19)</td>
<td align="char" valign="top" char="(" charoff="50">54 (8)</td>
<td align="char" valign="top" char="(" charoff="50">83 (10)</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Unspecified/other<xref ref-type="fn" rid="t1-fn4">c</xref>
</td>
<td align="char" valign="top" char="(" charoff="50">1 (1)</td>
<td align="char" valign="top" char="(" charoff="50">14 (2)</td>
<td align="char" valign="top" char="(" charoff="50">15 (2)</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn id="t1-fn1"><p>Abbreviations: GCIG=Gynaecologic Cancer Intergroup; RECIST=Response Evaluation Criteria in Solid Tumours.</p>
</fn>
<fn id="t1-fn2"><label>a</label>
<p>Including patients who experienced CA-125 or clinical progression within 7 days before or after RECIST progression.</p>
</fn>
<fn id="t1-fn3"><label>b</label>
<p>Including patients who experienced biological CA-125 within 3 days before or after clinical progression.</p>
</fn>
<fn id="t1-fn4"><label>c</label>
<p>Including tumour progression observed during surgical procedure.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="tbl2"><label>Table 2</label>
<caption><title>Baseline parameters associated with RECIST, CA125, or symptomatic progression (PD)</title>
</caption>
<table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col>
<col align="char" char="."></col>
<col align="char" char="."></col>
<col align="char" char="."></col>
</colgroup>
<thead valign="bottom"><tr><th align="left" valign="top" charoff="50"> </th>
<th colspan="3" align="center" valign="top" char="." charoff="50"><bold>Type of first PD</bold>
<hr></hr>
</th>
</tr>
<tr><th align="left" valign="top" charoff="50"> </th>
<th align="center" valign="top" char="." charoff="50"><bold>RECIST (%)</bold>
</th>
<th align="center" valign="top" char="." charoff="50"><bold>CA-125 (%)</bold>
</th>
<th align="center" valign="top" char="." charoff="50"><bold>Symptomatic (%)</bold>
</th>
</tr>
</thead>
<tbody valign="top"><tr><td align="left" valign="top" charoff="50">Proportion of progressions<xref ref-type="fn" rid="t2-fn2">a</xref>
</td>
<td align="char" valign="top" char="." charoff="50">60</td>
<td align="char" valign="top" char="." charoff="50">28</td>
<td align="char" valign="top" char="." charoff="50">10</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td colspan="4" align="left" valign="top" charoff="50"><italic>Histological subtype</italic>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Mucinous (<italic>n</italic>
=14)</td>
<td align="char" valign="top" char="." charoff="50">50</td>
<td align="char" valign="top" char="." charoff="50">21</td>
<td align="char" valign="top" char="." charoff="50">14</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Other (<italic>n</italic>
=818)</td>
<td align="char" valign="top" char="." charoff="50">61</td>
<td align="char" valign="top" char="." charoff="50">29</td>
<td align="char" valign="top" char="." charoff="50">12</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td colspan="4" align="left" valign="top" charoff="50"><italic>Measurable disease (TL)</italic>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Yes (<italic>n</italic>
=551)</td>
<td align="char" valign="top" char="." charoff="50">68</td>
<td align="char" valign="top" char="." charoff="50">22</td>
<td align="char" valign="top" char="." charoff="50">9</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> No (<italic>n</italic>
=281)</td>
<td align="char" valign="top" char="." charoff="50">46</td>
<td align="char" valign="top" char="." charoff="50">39</td>
<td align="char" valign="top" char="." charoff="50">12</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td colspan="4" align="left" valign="top" charoff="50"><italic>Assessable by CA-125</italic>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> Yes (<italic>n</italic>
=587)</td>
<td align="char" valign="top" char="." charoff="50">58</td>
<td align="char" valign="top" char="." charoff="50">32</td>
<td align="char" valign="top" char="." charoff="50">13</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> No (<italic>n</italic>
=243)</td>
<td align="char" valign="top" char="." charoff="50">65</td>
<td align="char" valign="top" char="." charoff="50">18</td>
<td align="char" valign="top" char="." charoff="50">9</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
<tr><td colspan="4" align="left" valign="top" charoff="50"><italic>Treatment arm</italic>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> C-P (<italic>n</italic>
=443)</td>
<td align="char" valign="top" char="." charoff="50">58</td>
<td align="char" valign="top" char="." charoff="50">28</td>
<td align="char" valign="top" char="." charoff="50">10</td>
</tr>
<tr><td align="left" valign="top" charoff="50"> C-PLD (<italic>n</italic>
=389)</td>
<td align="char" valign="top" char="." charoff="50">63</td>
<td align="char" valign="top" char="." charoff="50">27</td>
<td align="char" valign="top" char="." charoff="50">9</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn id="t2-fn1"><p>Abbreviations: C-P=carboplatin–paclitaxel; C-PLD=carboplatin-pegylated liposomal doxorubicin; PD=progressive disease; RECIST=Response Evaluation Criteria in Solid Tumours.</p>
</fn>
<fn id="t2-fn2"><label>a</label>
<p>The totals of the values do not equal 100% because progression of unspecified type and other progressions (<italic>n</italic>
=15) were not shown, patients not progressed excluded.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="tbl3"><label>Table 3</label>
<caption><title>Type of first progression and post-study therapy</title>
</caption>
<table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col>
<col align="char" char="."></col>
<col align="char" char="."></col>
<col align="char" char="."></col>
</colgroup>
<thead valign="bottom"><tr><th align="left" valign="top" charoff="50"> </th>
<th colspan="3" align="center" valign="top" char="." charoff="50"><bold>Type of first progression</bold>
<hr></hr>
</th>
</tr>
<tr><th align="left" valign="top" charoff="50"> </th>
<th align="center" valign="top" char="." charoff="50"><bold>RECIST</bold>
</th>
<th align="center" valign="top" char="." charoff="50"><bold>CA-125</bold>
</th>
<th align="center" valign="top" char="." charoff="50"><bold>Symptomatic</bold>
</th>
</tr>
</thead>
<tbody valign="top"><tr><td align="left" valign="top" charoff="50">Total number of progressions</td>
<td align="char" valign="top" char="." charoff="50">502</td>
<td align="char" valign="top" char="." charoff="50">232</td>
<td align="char" valign="top" char="." charoff="50">83</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Number of patients receiving new treatment after progression <italic>n</italic>
, (%)</td>
<td align="char" valign="top" char="." charoff="50">406 (81)</td>
<td align="char" valign="top" char="." charoff="50">189 (81)</td>
<td align="char" valign="top" char="." charoff="50">50 (60)</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Median time from first progression to new treatment (days)</td>
<td align="char" valign="top" char="." charoff="50">28</td>
<td align="char" valign="top" char="." charoff="50">60</td>
<td align="char" valign="top" char="." charoff="50">32</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn id="t3-fn1"><p>Abbreviation: RECIST=Response Evaluation Criteria in Solid Tumours.</p>
</fn>
</table-wrap-foot>
</table-wrap>
</floats-group>
</pmc>
</record>
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