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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Autophagy in malignant transformation and cancer progression</title><author><name sortKey="Galluzzi, Lorenzo" sort="Galluzzi, Lorenzo" uniqKey="Galluzzi L" first="Lorenzo" last="Galluzzi">Lorenzo Galluzzi</name><affiliation><nlm:aff id="au1"><institution>Equipe 11 labellisée pas la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au2"><institution>INSERM, U1138</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au3"><institution>Gustave Roussy Cancer Campus</institution><addr-line>Villejuif, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au4"><institution>Université Paris Descartes, Sorbonne Paris Cité</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pietrocola, Federico" sort="Pietrocola, Federico" uniqKey="Pietrocola F" first="Federico" last="Pietrocola">Federico Pietrocola</name><affiliation><nlm:aff id="au1"><institution>Equipe 11 labellisée pas la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au2"><institution>INSERM, U1138</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au3"><institution>Gustave Roussy Cancer Campus</institution><addr-line>Villejuif, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bravo San Pedro, Jose Manuel" sort="Bravo San Pedro, Jose Manuel" uniqKey="Bravo San Pedro J" first="José Manuel" last="Bravo-San Pedro">José Manuel Bravo-San Pedro</name><affiliation><nlm:aff id="au1"><institution>Equipe 11 labellisée pas la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au2"><institution>INSERM, U1138</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au3"><institution>Gustave Roussy Cancer Campus</institution><addr-line>Villejuif, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Amaravadi, Ravi K" sort="Amaravadi, Ravi K" uniqKey="Amaravadi R" first="Ravi K" last="Amaravadi">Ravi K. Amaravadi</name><affiliation><nlm:aff id="au5"><institution>Abramson Cancer Center, University of Pennsylvania</institution><addr-line>Philadelphia, PA, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Baehrecke, Eric H" sort="Baehrecke, Eric H" uniqKey="Baehrecke E" first="Eric H" last="Baehrecke">Eric H. Baehrecke</name><affiliation><nlm:aff id="au6"><institution>Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School</institution><addr-line>Worcester, MA, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cecconi, Francesco" sort="Cecconi, Francesco" uniqKey="Cecconi F" first="Francesco" last="Cecconi">Francesco Cecconi</name><affiliation><nlm:aff id="au7"><institution>Cell Stress and Survival Unit, Danish Cancer Society Research Center</institution><addr-line>Copenhagen, Denmark</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au8"><institution>IRCCS Fondazione Santa Lucia and Department of Biology, University of Rome Tor Vergata</institution><addr-line>Rome, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Codogno, Patrice" sort="Codogno, Patrice" uniqKey="Codogno P" first="Patrice" last="Codogno">Patrice Codogno</name><affiliation><nlm:aff id="au4"><institution>Université Paris Descartes, Sorbonne Paris Cité</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au9"><institution>Institut Necker Enfants-Malades (INEM)</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au10"><institution>INSERM, U1151</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au11"><institution>CNRS, UMR8253</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Debnath, Jayanta" sort="Debnath, Jayanta" uniqKey="Debnath J" first="Jayanta" last="Debnath">Jayanta Debnath</name><affiliation><nlm:aff id="au12"><institution>Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco</institution><addr-line>San Francisco, CA, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gewirtz, David A" sort="Gewirtz, David A" uniqKey="Gewirtz D" first="David A" last="Gewirtz">David A. Gewirtz</name><affiliation><nlm:aff id="au13"><institution>Department of Pharmacology, Toxicology and Medicine, Virginia Commonwealth University</institution><addr-line>Richmond, Virginia, VA, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Karantza, Vassiliki" sort="Karantza, Vassiliki" uniqKey="Karantza V" first="Vassiliki" last="Karantza">Vassiliki Karantza</name><affiliation><nlm:aff id="au14"><institution>Merck Research Laboratories</institution><addr-line>Rahway, NJ, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kimmelman, Alec" sort="Kimmelman, Alec" uniqKey="Kimmelman A" first="Alec" last="Kimmelman">Alec Kimmelman</name><affiliation><nlm:aff id="au15"><institution>Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana-Farber Cancer Institute</institution><addr-line>Boston, MA, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kumar, Sharad" sort="Kumar, Sharad" uniqKey="Kumar S" first="Sharad" last="Kumar">Sharad Kumar</name><affiliation><nlm:aff id="au16"><institution>Centre for Cancer Biology, University of South Australia</institution><addr-line>Adelaide, SA, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Levine, Beth" sort="Levine, Beth" uniqKey="Levine B" first="Beth" last="Levine">Beth Levine</name><affiliation><nlm:aff id="au17"><institution>Center for Autophagy Research, Department of Internal Medicine, University of Texas Southwestern Medical Center</institution><addr-line>Dallas, TX, USA</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au18"><institution>Department of Microbiology, University of Texas Southwestern Medical Center</institution><addr-line>Dallas, TX, USA</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au19"><institution>Howard Hughes Medical Institute, University of Texas Southwestern Medical Center</institution><addr-line>Dallas, TX, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Maiuri, Maria Chiara" sort="Maiuri, Maria Chiara" uniqKey="Maiuri M" first="Maria Chiara" last="Maiuri">Maria Chiara Maiuri</name><affiliation><nlm:aff id="au1"><institution>Equipe 11 labellisée pas la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au2"><institution>INSERM, U1138</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au3"><institution>Gustave Roussy Cancer Campus</institution><addr-line>Villejuif, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Martin, Seamus J" sort="Martin, Seamus J" uniqKey="Martin S" first="Seamus J" last="Martin">Seamus J. Martin</name><affiliation><nlm:aff id="au20"><institution>Department of Genetics, Trinity College, The Smurfit Institute</institution><addr-line>Dublin, Ireland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Penninger, Josef" sort="Penninger, Josef" uniqKey="Penninger J" first="Josef" last="Penninger">Josef Penninger</name><affiliation><nlm:aff id="au21"><institution>Institute of Molecular Biotechnology of the Austrian Academy of Sciences</institution><addr-line>Vienna, Austria</addr-line></nlm:aff></affiliation></author><author><name sortKey="Piacentini, Mauro" sort="Piacentini, Mauro" uniqKey="Piacentini M" first="Mauro" last="Piacentini">Mauro Piacentini</name><affiliation><nlm:aff id="au22"><institution>Department of Biology, University of Rome Tor Vergata</institution><addr-line>Rome, Italy</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au23"><institution>National Institute for Infectious Diseases IRCCS ‘Lazzaro Spallanzani’</institution><addr-line>Rome, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rubinsztein, David C" sort="Rubinsztein, David C" uniqKey="Rubinsztein D" first="David C" last="Rubinsztein">David C. Rubinsztein</name><affiliation><nlm:aff id="au24"><institution>Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge</institution><addr-line>Cambridge, UK</addr-line></nlm:aff></affiliation></author><author><name sortKey="Simon, Hans Uwe" sort="Simon, Hans Uwe" uniqKey="Simon H" first="Hans-Uwe" last="Simon">Hans-Uwe Simon</name><affiliation><nlm:aff id="au25"><institution>Institute of Pharmacology, University of Bern</institution><addr-line>Bern, Switzerland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Simonsen, Anne" sort="Simonsen, Anne" uniqKey="Simonsen A" first="Anne" last="Simonsen">Anne Simonsen</name><affiliation><nlm:aff id="au26"><institution>Institute of Basic Medical Sciences, University of Oslo</institution><addr-line>Oslo, Norway</addr-line></nlm:aff></affiliation></author><author><name sortKey="Thorburn, Andrew M" sort="Thorburn, Andrew M" uniqKey="Thorburn A" first="Andrew M" last="Thorburn">Andrew M. Thorburn</name><affiliation><nlm:aff id="au27"><institution>Department of Pharmacology, University of Colorado School of Medicine</institution><addr-line>Aurora, CO, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Velasco, Guillermo" sort="Velasco, Guillermo" uniqKey="Velasco G" first="Guillermo" last="Velasco">Guillermo Velasco</name><affiliation><nlm:aff id="au28"><institution>Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University of Madrid</institution><addr-line>Madrid, Spain</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au29"><institution>Instituto de Investigaciones Sanitarias San Carlos (IdISSC)</institution><addr-line>Madrid, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ryan, Kevin M" sort="Ryan, Kevin M" uniqKey="Ryan K" first="Kevin M" last="Ryan">Kevin M. Ryan</name><affiliation><nlm:aff id="au30"><institution>Cancer Research UK Beatson Institute</institution><addr-line>Glasgow, UK</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name><affiliation><nlm:aff id="au1"><institution>Equipe 11 labellisée pas la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au2"><institution>INSERM, U1138</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au4"><institution>Université Paris Descartes, Sorbonne Paris Cité</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au31"><institution>Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au32"><institution>Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus</institution><addr-line>Villejuif, France</addr-line></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25712477</idno><idno type="pmc">4388596</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388596</idno><idno type="RBID">PMC:4388596</idno><idno type="doi">10.15252/embj.201490784</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">002E81</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E81</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Autophagy in malignant transformation and cancer progression</title><author><name sortKey="Galluzzi, Lorenzo" sort="Galluzzi, Lorenzo" uniqKey="Galluzzi L" first="Lorenzo" last="Galluzzi">Lorenzo Galluzzi</name><affiliation><nlm:aff id="au1"><institution>Equipe 11 labellisée pas la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au2"><institution>INSERM, U1138</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au3"><institution>Gustave Roussy Cancer Campus</institution><addr-line>Villejuif, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au4"><institution>Université Paris Descartes, Sorbonne Paris Cité</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pietrocola, Federico" sort="Pietrocola, Federico" uniqKey="Pietrocola F" first="Federico" last="Pietrocola">Federico Pietrocola</name><affiliation><nlm:aff id="au1"><institution>Equipe 11 labellisée pas la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au2"><institution>INSERM, U1138</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au3"><institution>Gustave Roussy Cancer Campus</institution><addr-line>Villejuif, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bravo San Pedro, Jose Manuel" sort="Bravo San Pedro, Jose Manuel" uniqKey="Bravo San Pedro J" first="José Manuel" last="Bravo-San Pedro">José Manuel Bravo-San Pedro</name><affiliation><nlm:aff id="au1"><institution>Equipe 11 labellisée pas la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au2"><institution>INSERM, U1138</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au3"><institution>Gustave Roussy Cancer Campus</institution><addr-line>Villejuif, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Amaravadi, Ravi K" sort="Amaravadi, Ravi K" uniqKey="Amaravadi R" first="Ravi K" last="Amaravadi">Ravi K. Amaravadi</name><affiliation><nlm:aff id="au5"><institution>Abramson Cancer Center, University of Pennsylvania</institution><addr-line>Philadelphia, PA, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Baehrecke, Eric H" sort="Baehrecke, Eric H" uniqKey="Baehrecke E" first="Eric H" last="Baehrecke">Eric H. Baehrecke</name><affiliation><nlm:aff id="au6"><institution>Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School</institution><addr-line>Worcester, MA, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cecconi, Francesco" sort="Cecconi, Francesco" uniqKey="Cecconi F" first="Francesco" last="Cecconi">Francesco Cecconi</name><affiliation><nlm:aff id="au7"><institution>Cell Stress and Survival Unit, Danish Cancer Society Research Center</institution><addr-line>Copenhagen, Denmark</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au8"><institution>IRCCS Fondazione Santa Lucia and Department of Biology, University of Rome Tor Vergata</institution><addr-line>Rome, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Codogno, Patrice" sort="Codogno, Patrice" uniqKey="Codogno P" first="Patrice" last="Codogno">Patrice Codogno</name><affiliation><nlm:aff id="au4"><institution>Université Paris Descartes, Sorbonne Paris Cité</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au9"><institution>Institut Necker Enfants-Malades (INEM)</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au10"><institution>INSERM, U1151</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au11"><institution>CNRS, UMR8253</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Debnath, Jayanta" sort="Debnath, Jayanta" uniqKey="Debnath J" first="Jayanta" last="Debnath">Jayanta Debnath</name><affiliation><nlm:aff id="au12"><institution>Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco</institution><addr-line>San Francisco, CA, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gewirtz, David A" sort="Gewirtz, David A" uniqKey="Gewirtz D" first="David A" last="Gewirtz">David A. Gewirtz</name><affiliation><nlm:aff id="au13"><institution>Department of Pharmacology, Toxicology and Medicine, Virginia Commonwealth University</institution><addr-line>Richmond, Virginia, VA, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Karantza, Vassiliki" sort="Karantza, Vassiliki" uniqKey="Karantza V" first="Vassiliki" last="Karantza">Vassiliki Karantza</name><affiliation><nlm:aff id="au14"><institution>Merck Research Laboratories</institution><addr-line>Rahway, NJ, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kimmelman, Alec" sort="Kimmelman, Alec" uniqKey="Kimmelman A" first="Alec" last="Kimmelman">Alec Kimmelman</name><affiliation><nlm:aff id="au15"><institution>Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana-Farber Cancer Institute</institution><addr-line>Boston, MA, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kumar, Sharad" sort="Kumar, Sharad" uniqKey="Kumar S" first="Sharad" last="Kumar">Sharad Kumar</name><affiliation><nlm:aff id="au16"><institution>Centre for Cancer Biology, University of South Australia</institution><addr-line>Adelaide, SA, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Levine, Beth" sort="Levine, Beth" uniqKey="Levine B" first="Beth" last="Levine">Beth Levine</name><affiliation><nlm:aff id="au17"><institution>Center for Autophagy Research, Department of Internal Medicine, University of Texas Southwestern Medical Center</institution><addr-line>Dallas, TX, USA</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au18"><institution>Department of Microbiology, University of Texas Southwestern Medical Center</institution><addr-line>Dallas, TX, USA</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au19"><institution>Howard Hughes Medical Institute, University of Texas Southwestern Medical Center</institution><addr-line>Dallas, TX, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Maiuri, Maria Chiara" sort="Maiuri, Maria Chiara" uniqKey="Maiuri M" first="Maria Chiara" last="Maiuri">Maria Chiara Maiuri</name><affiliation><nlm:aff id="au1"><institution>Equipe 11 labellisée pas la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au2"><institution>INSERM, U1138</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au3"><institution>Gustave Roussy Cancer Campus</institution><addr-line>Villejuif, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Martin, Seamus J" sort="Martin, Seamus J" uniqKey="Martin S" first="Seamus J" last="Martin">Seamus J. Martin</name><affiliation><nlm:aff id="au20"><institution>Department of Genetics, Trinity College, The Smurfit Institute</institution><addr-line>Dublin, Ireland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Penninger, Josef" sort="Penninger, Josef" uniqKey="Penninger J" first="Josef" last="Penninger">Josef Penninger</name><affiliation><nlm:aff id="au21"><institution>Institute of Molecular Biotechnology of the Austrian Academy of Sciences</institution><addr-line>Vienna, Austria</addr-line></nlm:aff></affiliation></author><author><name sortKey="Piacentini, Mauro" sort="Piacentini, Mauro" uniqKey="Piacentini M" first="Mauro" last="Piacentini">Mauro Piacentini</name><affiliation><nlm:aff id="au22"><institution>Department of Biology, University of Rome Tor Vergata</institution><addr-line>Rome, Italy</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au23"><institution>National Institute for Infectious Diseases IRCCS ‘Lazzaro Spallanzani’</institution><addr-line>Rome, Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rubinsztein, David C" sort="Rubinsztein, David C" uniqKey="Rubinsztein D" first="David C" last="Rubinsztein">David C. Rubinsztein</name><affiliation><nlm:aff id="au24"><institution>Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge</institution><addr-line>Cambridge, UK</addr-line></nlm:aff></affiliation></author><author><name sortKey="Simon, Hans Uwe" sort="Simon, Hans Uwe" uniqKey="Simon H" first="Hans-Uwe" last="Simon">Hans-Uwe Simon</name><affiliation><nlm:aff id="au25"><institution>Institute of Pharmacology, University of Bern</institution><addr-line>Bern, Switzerland</addr-line></nlm:aff></affiliation></author><author><name sortKey="Simonsen, Anne" sort="Simonsen, Anne" uniqKey="Simonsen A" first="Anne" last="Simonsen">Anne Simonsen</name><affiliation><nlm:aff id="au26"><institution>Institute of Basic Medical Sciences, University of Oslo</institution><addr-line>Oslo, Norway</addr-line></nlm:aff></affiliation></author><author><name sortKey="Thorburn, Andrew M" sort="Thorburn, Andrew M" uniqKey="Thorburn A" first="Andrew M" last="Thorburn">Andrew M. Thorburn</name><affiliation><nlm:aff id="au27"><institution>Department of Pharmacology, University of Colorado School of Medicine</institution><addr-line>Aurora, CO, USA</addr-line></nlm:aff></affiliation></author><author><name sortKey="Velasco, Guillermo" sort="Velasco, Guillermo" uniqKey="Velasco G" first="Guillermo" last="Velasco">Guillermo Velasco</name><affiliation><nlm:aff id="au28"><institution>Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University of Madrid</institution><addr-line>Madrid, Spain</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au29"><institution>Instituto de Investigaciones Sanitarias San Carlos (IdISSC)</institution><addr-line>Madrid, Spain</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ryan, Kevin M" sort="Ryan, Kevin M" uniqKey="Ryan K" first="Kevin M" last="Ryan">Kevin M. Ryan</name><affiliation><nlm:aff id="au30"><institution>Cancer Research UK Beatson Institute</institution><addr-line>Glasgow, UK</addr-line></nlm:aff></affiliation></author><author><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name><affiliation><nlm:aff id="au1"><institution>Equipe 11 labellisée pas la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au2"><institution>INSERM, U1138</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au4"><institution>Université Paris Descartes, Sorbonne Paris Cité</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au31"><institution>Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au32"><institution>Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus</institution><addr-line>Villejuif, France</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">The EMBO Journal</title><idno type="ISSN">0261-4189</idno><idno type="eISSN">1460-2075</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Autophagy plays a key role in the maintenance of cellular homeostasis. In healthy cells, such a homeostatic activity constitutes a robust barrier against malignant transformation. Accordingly, many oncoproteins inhibit, and several oncosuppressor proteins promote, autophagy. Moreover, autophagy is required for optimal anticancer immunosurveillance. In neoplastic cells, however, autophagic responses constitute a means to cope with intracellular and environmental stress, thus favoring tumor progression. This implies that at least in some cases, oncogenesis proceeds along with a temporary inhibition of autophagy or a gain of molecular functions that antagonize its oncosuppressive activity. Here, we discuss the differential impact of autophagy on distinct phases of tumorigenesis and the implications of this concept for the use of autophagy modulators in cancer therapy.</p></div></front></TEI><pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">EMBO J</journal-id><journal-id journal-id-type="iso-abbrev">EMBO J</journal-id><journal-id journal-id-type="publisher-id">embj</journal-id><journal-title-group><journal-title>The EMBO Journal</journal-title></journal-title-group><issn pub-type="ppub">0261-4189</issn><issn pub-type="epub">1460-2075</issn><publisher><publisher-name>BlackWell Publishing Ltd</publisher-name><publisher-loc>Oxford, UK</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25712477</article-id><article-id pub-id-type="pmc">4388596</article-id><article-id pub-id-type="doi">10.15252/embj.201490784</article-id><article-categories><subj-group subj-group-type="heading"><subject>Reviews</subject></subj-group></article-categories><title-group><article-title>Autophagy in malignant transformation and cancer progression</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Galluzzi</surname><given-names>Lorenzo</given-names></name><xref ref-type="aff" rid="au1">1</xref><xref ref-type="aff" rid="au2">2</xref><xref ref-type="aff" rid="au3">3</xref><xref ref-type="aff" rid="au4">4</xref><xref ref-type="corresp" rid="cor1">*</xref><xref ref-type="author-notes" rid="fn1">†</xref><xref ref-type="author-notes" rid="fn2">‡</xref></contrib><contrib contrib-type="author"><name><surname>Pietrocola</surname><given-names>Federico</given-names></name><xref ref-type="aff" rid="au1">1</xref><xref ref-type="aff" rid="au2">2</xref><xref ref-type="aff" rid="au3">3</xref><xref ref-type="author-notes" rid="fn1">†</xref></contrib><contrib contrib-type="author"><name><surname>Bravo-San Pedro</surname><given-names>José Manuel</given-names></name><xref ref-type="aff" rid="au1">1</xref><xref ref-type="aff" rid="au2">2</xref><xref ref-type="aff" rid="au3">3</xref><xref ref-type="author-notes" rid="fn1">†</xref></contrib><contrib contrib-type="author"><name><surname>Amaravadi</surname><given-names>Ravi K</given-names></name><xref ref-type="aff" rid="au5">5</xref></contrib><contrib contrib-type="author"><name><surname>Baehrecke</surname><given-names>Eric H</given-names></name><xref ref-type="aff" rid="au6">6</xref></contrib><contrib contrib-type="author"><name><surname>Cecconi</surname><given-names>Francesco</given-names></name><xref ref-type="aff" rid="au7">7</xref><xref ref-type="aff" rid="au8">8</xref></contrib><contrib contrib-type="author"><name><surname>Codogno</surname><given-names>Patrice</given-names></name><xref ref-type="aff" rid="au4">4</xref><xref ref-type="aff" rid="au9">9</xref><xref ref-type="aff" rid="au10">10</xref><xref ref-type="aff" rid="au11">11</xref></contrib><contrib contrib-type="author"><name><surname>Debnath</surname><given-names>Jayanta</given-names></name><xref ref-type="aff" rid="au12">12</xref></contrib><contrib contrib-type="author"><name><surname>Gewirtz</surname><given-names>David A</given-names></name><xref ref-type="aff" rid="au13">13</xref></contrib><contrib contrib-type="author"><name><surname>Karantza</surname><given-names>Vassiliki</given-names></name><xref ref-type="aff" rid="au14">14</xref></contrib><contrib contrib-type="author"><name><surname>Kimmelman</surname><given-names>Alec</given-names></name><xref ref-type="aff" rid="au15">15</xref></contrib><contrib contrib-type="author"><name><surname>Kumar</surname><given-names>Sharad</given-names></name><xref ref-type="aff" rid="au16">16</xref></contrib><contrib contrib-type="author"><name><surname>Levine</surname><given-names>Beth</given-names></name><xref ref-type="aff" rid="au17">17</xref><xref ref-type="aff" rid="au18">18</xref><xref ref-type="aff" rid="au19">19</xref></contrib><contrib contrib-type="author"><name><surname>Maiuri</surname><given-names>Maria Chiara</given-names></name><xref ref-type="aff" rid="au1">1</xref><xref ref-type="aff" rid="au2">2</xref><xref ref-type="aff" rid="au3">3</xref></contrib><contrib contrib-type="author"><name><surname>Martin</surname><given-names>Seamus J</given-names></name><xref ref-type="aff" rid="au20">20</xref></contrib><contrib contrib-type="author"><name><surname>Penninger</surname><given-names>Josef</given-names></name><xref ref-type="aff" rid="au21">21</xref></contrib><contrib contrib-type="author"><name><surname>Piacentini</surname><given-names>Mauro</given-names></name><xref ref-type="aff" rid="au22">22</xref><xref ref-type="aff" rid="au23">23</xref></contrib><contrib contrib-type="author"><name><surname>Rubinsztein</surname><given-names>David C</given-names></name><xref ref-type="aff" rid="au24">24</xref></contrib><contrib contrib-type="author"><name><surname>Simon</surname><given-names>Hans-Uwe</given-names></name><xref ref-type="aff" rid="au25">25</xref></contrib><contrib contrib-type="author"><name><surname>Simonsen</surname><given-names>Anne</given-names></name><xref ref-type="aff" rid="au26">26</xref></contrib><contrib contrib-type="author"><name><surname>Thorburn</surname><given-names>Andrew M</given-names></name><xref ref-type="aff" rid="au27">27</xref></contrib><contrib contrib-type="author"><name><surname>Velasco</surname><given-names>Guillermo</given-names></name><xref ref-type="aff" rid="au28">28</xref><xref ref-type="aff" rid="au29">29</xref></contrib><contrib contrib-type="author"><name><surname>Ryan</surname><given-names>Kevin M</given-names></name><xref ref-type="aff" rid="au30">30</xref><xref ref-type="author-notes" rid="fn2">‡</xref></contrib><contrib contrib-type="author"><name><surname>Kroemer</surname><given-names>Guido</given-names></name><xref ref-type="aff" rid="au1">1</xref><xref ref-type="aff" rid="au2">2</xref><xref ref-type="aff" rid="au4">4</xref><xref ref-type="aff" rid="au31">31</xref><xref ref-type="aff" rid="au32">32</xref><xref ref-type="author-notes" rid="fn2">‡</xref></contrib><aff id="au1"><label>1</label><institution>Equipe 11 labellisée pas la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers</institution><addr-line>Paris, France</addr-line></aff><aff id="au2"><label>2</label><institution>INSERM, U1138</institution><addr-line>Paris, France</addr-line></aff><aff id="au3"><label>3</label><institution>Gustave Roussy Cancer Campus</institution><addr-line>Villejuif, France</addr-line></aff><aff id="au4"><label>4</label><institution>Université Paris Descartes, Sorbonne Paris Cité</institution><addr-line>Paris, France</addr-line></aff><aff id="au5"><label>5</label><institution>Abramson Cancer Center, University of Pennsylvania</institution><addr-line>Philadelphia, PA, USA</addr-line></aff><aff id="au6"><label>6</label><institution>Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School</institution><addr-line>Worcester, MA, USA</addr-line></aff><aff id="au7"><label>7</label><institution>Cell Stress and Survival Unit, Danish Cancer Society Research Center</institution><addr-line>Copenhagen, Denmark</addr-line></aff><aff id="au8"><label>8</label><institution>IRCCS Fondazione Santa Lucia and Department of Biology, University of Rome Tor Vergata</institution><addr-line>Rome, Italy</addr-line></aff><aff id="au9"><label>9</label><institution>Institut Necker Enfants-Malades (INEM)</institution><addr-line>Paris, France</addr-line></aff><aff id="au10"><label>10</label><institution>INSERM, U1151</institution><addr-line>Paris, France</addr-line></aff><aff id="au11"><label>11</label><institution>CNRS, UMR8253</institution><addr-line>Paris, France</addr-line></aff><aff id="au12"><label>12</label><institution>Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco</institution><addr-line>San Francisco, CA, USA</addr-line></aff><aff id="au13"><label>13</label><institution>Department of Pharmacology, Toxicology and Medicine, Virginia Commonwealth University</institution><addr-line>Richmond, Virginia, VA, USA</addr-line></aff><aff id="au14"><label>14</label><institution>Merck Research Laboratories</institution><addr-line>Rahway, NJ, USA</addr-line></aff><aff id="au15"><label>15</label><institution>Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana-Farber Cancer Institute</institution><addr-line>Boston, MA, USA</addr-line></aff><aff id="au16"><label>16</label><institution>Centre for Cancer Biology, University of South Australia</institution><addr-line>Adelaide, SA, Australia</addr-line></aff><aff id="au17"><label>17</label><institution>Center for Autophagy Research, Department of Internal Medicine, University of Texas Southwestern Medical Center</institution><addr-line>Dallas, TX, USA</addr-line></aff><aff id="au18"><label>18</label><institution>Department of Microbiology, University of Texas Southwestern Medical Center</institution><addr-line>Dallas, TX, USA</addr-line></aff><aff id="au19"><label>19</label><institution>Howard Hughes Medical Institute, University of Texas Southwestern Medical Center</institution><addr-line>Dallas, TX, USA</addr-line></aff><aff id="au20"><label>20</label><institution>Department of Genetics, Trinity College, The Smurfit Institute</institution><addr-line>Dublin, Ireland</addr-line></aff><aff id="au21"><label>21</label><institution>Institute of Molecular Biotechnology of the Austrian Academy of Sciences</institution><addr-line>Vienna, Austria</addr-line></aff><aff id="au22"><label>22</label><institution>Department of Biology, University of Rome Tor Vergata</institution><addr-line>Rome, Italy</addr-line></aff><aff id="au23"><label>23</label><institution>National Institute for Infectious Diseases IRCCS ‘Lazzaro Spallanzani’</institution><addr-line>Rome, Italy</addr-line></aff><aff id="au24"><label>24</label><institution>Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge</institution><addr-line>Cambridge, UK</addr-line></aff><aff id="au25"><label>25</label><institution>Institute of Pharmacology, University of Bern</institution><addr-line>Bern, Switzerland</addr-line></aff><aff id="au26"><label>26</label><institution>Institute of Basic Medical Sciences, University of Oslo</institution><addr-line>Oslo, Norway</addr-line></aff><aff id="au27"><label>27</label><institution>Department of Pharmacology, University of Colorado School of Medicine</institution><addr-line>Aurora, CO, USA</addr-line></aff><aff id="au28"><label>28</label><institution>Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University of Madrid</institution><addr-line>Madrid, Spain</addr-line></aff><aff id="au29"><label>29</label><institution>Instituto de Investigaciones Sanitarias San Carlos (IdISSC)</institution><addr-line>Madrid, Spain</addr-line></aff><aff id="au30"><label>30</label><institution>Cancer Research UK Beatson Institute</institution><addr-line>Glasgow, UK</addr-line></aff><aff id="au31"><label>31</label><institution>Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP</institution><addr-line>Paris, France</addr-line></aff><aff id="au32"><label>32</label><institution>Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus</institution><addr-line>Villejuif, France</addr-line></aff></contrib-group><author-notes><corresp id="cor1">* Corresponding author. Tel: +33 1 44277661; E-mail: <email>deadoc@vodafone.it</email></corresp><fn id="fn1"><label>†</label><p>These authors contributed equally to this work</p></fn><fn id="fn2"><label>‡</label><p>These authors share senior co-authorship</p></fn></author-notes><pub-date pub-type="ppub"><day>01</day><month>4</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>23</day><month>2</month><year>2015</year></pub-date><volume>34</volume><issue>7</issue><fpage>856</fpage><lpage>880</lpage><history><date date-type="received"><day>12</day><month>12</month><year>2014</year></date><date date-type="rev-recd"><day>14</day><month>1</month><year>2015</year></date><date date-type="accepted"><day>16</day><month>1</month><year>2015</year></date></history><permissions><copyright-statement>© 2015 The Authors</copyright-statement><copyright-year>2015</copyright-year></permissions><abstract><p>Autophagy plays a key role in the maintenance of cellular homeostasis. In healthy cells, such a homeostatic activity constitutes a robust barrier against malignant transformation. Accordingly, many oncoproteins inhibit, and several oncosuppressor proteins promote, autophagy. Moreover, autophagy is required for optimal anticancer immunosurveillance. In neoplastic cells, however, autophagic responses constitute a means to cope with intracellular and environmental stress, thus favoring tumor progression. This implies that at least in some cases, oncogenesis proceeds along with a temporary inhibition of autophagy or a gain of molecular functions that antagonize its oncosuppressive activity. Here, we discuss the differential impact of autophagy on distinct phases of tumorigenesis and the implications of this concept for the use of autophagy modulators in cancer therapy.</p></abstract><kwd-group><kwd>adaptive stress responses</kwd><kwd>Beclin 1</kwd><kwd>inflammation</kwd><kwd>KRAS</kwd><kwd>mitophagy</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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