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<title xml:lang="en">Child Health, Developmental Plasticity, and Epigenetic Programming</title>
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<name sortKey="Feil, R" sort="Feil, R" uniqKey="Feil R" first="R." last="Feil">R. Feil</name>
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<name sortKey="Junien, C" sort="Junien, C" uniqKey="Junien C" first="C." last="Junien">C. Junien</name>
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<name sortKey="Carel, J C" sort="Carel, J C" uniqKey="Carel J" first="J.-C." last="Carel">J.-C. Carel</name>
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<name sortKey="Waterland, R A" sort="Waterland, R A" uniqKey="Waterland R" first="R. A." last="Waterland">R. A. Waterland</name>
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<name sortKey="Waxman, D J" sort="Waxman, D J" uniqKey="Waxman D" first="D. J." last="Waxman">D. J. Waxman</name>
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<name sortKey="Whitelaw, E" sort="Whitelaw, E" uniqKey="Whitelaw E" first="E." last="Whitelaw">E. Whitelaw</name>
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<name sortKey="Ong, K" sort="Ong, K" uniqKey="Ong K" first="K." last="Ong">K. Ong</name>
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<name sortKey="Albertsson Wikland, K" sort="Albertsson Wikland, K" uniqKey="Albertsson Wikland K" first="K." last="Albertsson-Wikland">K. Albertsson-Wikland</name>
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<title xml:lang="en" level="a" type="main">Child Health, Developmental Plasticity, and Epigenetic Programming</title>
<author>
<name sortKey="Hochberg, Z" sort="Hochberg, Z" uniqKey="Hochberg Z" first="Z." last="Hochberg">Z. Hochberg</name>
</author>
<author>
<name sortKey="Feil, R" sort="Feil, R" uniqKey="Feil R" first="R." last="Feil">R. Feil</name>
</author>
<author>
<name sortKey="Constancia, M" sort="Constancia, M" uniqKey="Constancia M" first="M." last="Constancia">M. Constancia</name>
</author>
<author>
<name sortKey="Fraga, M" sort="Fraga, M" uniqKey="Fraga M" first="M." last="Fraga">M. Fraga</name>
</author>
<author>
<name sortKey="Junien, C" sort="Junien, C" uniqKey="Junien C" first="C." last="Junien">C. Junien</name>
</author>
<author>
<name sortKey="Carel, J C" sort="Carel, J C" uniqKey="Carel J" first="J.-C." last="Carel">J.-C. Carel</name>
</author>
<author>
<name sortKey="Boileau, P" sort="Boileau, P" uniqKey="Boileau P" first="P." last="Boileau">P. Boileau</name>
</author>
<author>
<name sortKey="Le Bouc, Y" sort="Le Bouc, Y" uniqKey="Le Bouc Y" first="Y." last="Le Bouc">Y. Le Bouc</name>
</author>
<author>
<name sortKey="Deal, C L" sort="Deal, C L" uniqKey="Deal C" first="C. L." last="Deal">C. L. Deal</name>
</author>
<author>
<name sortKey="Lillycrop, K" sort="Lillycrop, K" uniqKey="Lillycrop K" first="K." last="Lillycrop">K. Lillycrop</name>
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<name sortKey="Scharfmann, R" sort="Scharfmann, R" uniqKey="Scharfmann R" first="R." last="Scharfmann">R. Scharfmann</name>
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<name sortKey="Sheppard, A" sort="Sheppard, A" uniqKey="Sheppard A" first="A." last="Sheppard">A. Sheppard</name>
</author>
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<name sortKey="Skinner, M" sort="Skinner, M" uniqKey="Skinner M" first="M." last="Skinner">M. Skinner</name>
</author>
<author>
<name sortKey="Szyf, M" sort="Szyf, M" uniqKey="Szyf M" first="M." last="Szyf">M. Szyf</name>
</author>
<author>
<name sortKey="Waterland, R A" sort="Waterland, R A" uniqKey="Waterland R" first="R. A." last="Waterland">R. A. Waterland</name>
</author>
<author>
<name sortKey="Waxman, D J" sort="Waxman, D J" uniqKey="Waxman D" first="D. J." last="Waxman">D. J. Waxman</name>
</author>
<author>
<name sortKey="Whitelaw, E" sort="Whitelaw, E" uniqKey="Whitelaw E" first="E." last="Whitelaw">E. Whitelaw</name>
</author>
<author>
<name sortKey="Ong, K" sort="Ong, K" uniqKey="Ong K" first="K." last="Ong">K. Ong</name>
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<name sortKey="Albertsson Wikland, K" sort="Albertsson Wikland, K" uniqKey="Albertsson Wikland K" first="K." last="Albertsson-Wikland">K. Albertsson-Wikland</name>
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<series>
<title level="j">Endocrine Reviews</title>
<idno type="ISSN">0163-769X</idno>
<idno type="eISSN">1945-7189</idno>
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<date when="2010">2010</date>
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<div type="abstract" xml:lang="en">
<p>Plasticity in developmental programming has evolved to provide the best chances of survival and reproductive success to the organism under changing environments. The window of developmental plasticity extends from preconception to early childhood, and involves epigenetic responses to environmental changes, which exert their effects during life history phase-transitions. This review provides a comprehensive presentation of translational epigenetics as it pertains to child health, growth, and maturation. Identifying the epigenetic consequences of fetal programming creates potential applications in clinical practice: the development of epigenetic biomarkers for early diagnosis of disease, the ability to identify susceptible individuals at risk for adult diseases, and the development of novel preventive and curative measures that are based on diet and/or novel epigenetic drugs.</p>
</div>
</front>
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<pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-ta">Endocr Rev</journal-id>
<journal-id journal-id-type="iso-abbrev">Endocr. Rev</journal-id>
<journal-id journal-id-type="hwp">edrv</journal-id>
<journal-id journal-id-type="publisher-id">endre</journal-id>
<journal-id journal-id-type="pmc">edrv</journal-id>
<journal-id journal-id-type="publisher-id">edrv</journal-id>
<journal-title-group>
<journal-title>Endocrine Reviews</journal-title>
</journal-title-group>
<issn pub-type="ppub">0163-769X</issn>
<issn pub-type="epub">1945-7189</issn>
<publisher>
<publisher-name>Endocrine Society</publisher-name>
<publisher-loc>Chevy Chase, MD</publisher-loc>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">20971919</article-id>
<article-id pub-id-type="pmc">3365792</article-id>
<article-id pub-id-type="publisher-id">ER-09-0039</article-id>
<article-id pub-id-type="doi">10.1210/er.2009-0039</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Reviews</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Child Health, Developmental Plasticity, and Epigenetic Programming</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes">
<name>
<surname>Hochberg</surname>
<given-names>Z.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Feil</surname>
<given-names>R.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Constancia</surname>
<given-names>M.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Fraga</surname>
<given-names>M.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Junien</surname>
<given-names>C.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Carel</surname>
<given-names>J.-C.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Boileau</surname>
<given-names>P.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Le Bouc</surname>
<given-names>Y.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Deal</surname>
<given-names>C. L.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Lillycrop</surname>
<given-names>K.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Scharfmann</surname>
<given-names>R.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Sheppard</surname>
<given-names>A.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Skinner</surname>
<given-names>M.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Szyf</surname>
<given-names>M.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Waterland</surname>
<given-names>R. A.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Waxman</surname>
<given-names>D. J.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Whitelaw</surname>
<given-names>E.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Ong</surname>
<given-names>K.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Albertsson-Wikland</surname>
<given-names>K.</given-names>
</name>
</contrib>
<aff>Rambam Medical Center and Rappaport Faculty of Medicine and Research Institute (Z.H.), Technion–Israel Institute of Technology, Haifa 31096, Israel; Institute of Molecular Genetics (R.F.), Centre National de la Recherche Scientifique and University of Montpellier, 34293 Montpellier, France; Metabolic Research Laboratories (M.C.), Department of Obstetrics and Gynecology, University of Cambridge, Cambridge CB3 9EF, United Kingdom; Centro Nacional de Biotechnologia (M.F.), University of Oviedo, 33003 Oviedo, Spain; Biologie du Développement et Reproduction (C.J.), Hospital Ambroise Paré, F-78352 Jouy en Josas, France; Endocrinologie Diabétologie Pédiatrique and Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 690 (J.-C.C.), Hôpital Robert Debré, Paris 75019, France; Université Paris-Sud (P.B.), Neonatal Intensive Care Unit, Hôpital Antoine-Béclère, 92140 Clamart, France; Pediatric Endocrine Investigation Department (Y.L.B.), Trousseau Hospital, 75012 Paris, France; Université de Montréal Endocrine Service (C.L.D.), Hôpital Sainte-Justine, Montreal, Quebec, Canada H3G 1A4; Development and Cell Biology (K.L.), University of Southampton, Southampton SO17 1BJ, United Kingdom; INSERM Unité 845 (R.S.), Research Center Growth and Signaling, University Paris Descartes, 75005 Paris, France; Liggins Institute (A.S.), University of Auckland and National Research Centre for Growth and Development, Auckland 1010, New Zealand; School of Molecular Biosciences (M.Sk.), Washington State University, Pullman, Washington 99164; Department of Pharmacology and Therapeutics (M.Sz.), McGill University, Montreal, Quebec, Canada H2X 3P8; U.S. Department of Agriculture Children's Nutrition Research Center (R.A.W.), Departments of Pediatrics and Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030; Department of Biology (D.J.W.), Boston University, Boston, Massachusetts 02215; Queensland Institute of Medical Research (E.W.), Brisbane, Queensland 4006, Australia; Medical Research Council Epidemiology Unit (K.O.), Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom; and Göteborg Pediatric Research Centre (K.A.-W.), Sahlgrenska Academy at Göteborg University, 413 45 Göteborg, Sweden</aff>
</contrib-group>
<author-notes>
<corresp>Address all correspondence and requests for reprints to: Prof. Ze'ev Hochberg,
<addr-line>Rambam Medical Center, POB 9602, Haifa 31096, Israel.</addr-line>
E-mail:
<email>z_hochberg@rambam.health.gov.il</email>
.</corresp>
</author-notes>
<pub-date pub-type="ppub">
<month>4</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="epub">
<day>22</day>
<month>10</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="pmc-release">
<day>1</day>
<month>4</month>
<year>2012</year>
</pub-date>
<pmc-comment> PMC Release delay is 12 months and 0 days and was based on the . </pmc-comment>
<volume>32</volume>
<issue>2</issue>
<fpage>159</fpage>
<lpage>224</lpage>
<history>
<date date-type="received">
<day>23</day>
<month>9</month>
<year>2009</year>
</date>
<date date-type="accepted">
<day>27</day>
<month>8</month>
<year>2010</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright © 2011 by The Endocrine Society</copyright-statement>
<copyright-year>2011</copyright-year>
</permissions>
<self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zef00211000159.pdf"></self-uri>
<abstract abstract-type="precis">
<p>Plasticity in developmental programming has evolved to provide the best chances of survival and reproductive success to the organism under changing environments. The window of developmental plasticity extends from preconception to early childhood, and involves epigenetic responses to environmental changes, which exert their effects during life history phase-transitions. This review provides a comprehensive presentation of translational epigenetics as it pertains to child health, growth, and maturation. Identifying the epigenetic consequences of fetal programming creates potential applications in clinical practice: the development of epigenetic biomarkers for early diagnosis of disease, the ability to identify susceptible individuals at risk for adult diseases, and the development of novel preventive and curative measures that are based on diet and/or novel epigenetic drugs.</p>
</abstract>
<abstract>
<p>Plasticity in developmental programming has evolved in order to provide the best chances of survival and reproductive success to the organism under changing environments. Environmental conditions that are experienced in early life can profoundly influence human biology and long-term health. Developmental origins of health and disease and life-history transitions are purported to use placental, nutritional, and endocrine cues for setting long-term biological, mental, and behavioral strategies in response to local ecological and/or social conditions. The window of developmental plasticity extends from preconception to early childhood and involves epigenetic responses to environmental changes, which exert their effects during life-history phase transitions. These epigenetic responses influence development, cell- and tissue-specific gene expression, and sexual dimorphism, and, in exceptional cases, could be transmitted transgenerationally. Translational epigenetic research in child health is a reiterative process that ranges from research in the basic sciences, preclinical research, and pediatric clinical research. Identifying the epigenetic consequences of fetal programming creates potential applications in clinical practice: the development of epigenetic biomarkers for early diagnosis of disease, the ability to identify susceptible individuals at risk for adult diseases, and the development of novel preventive and curative measures that are based on diet and/or novel epigenetic drugs.</p>
</abstract>
</article-meta>
</front>
</pmc>
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