AustralieFrV1, Pmc, Corpus, bibRecord, 002194

Killer cell immunoglobulin-like receptor ligand matching and outcomes after unrelated cord blood transplantation acute myeloid leukemia

Identifieur interne : 002194 ( Pmc/Corpus ); précédent : 002193; suivant : 002195

Killer cell immunoglobulin-like receptor ligand matching and outcomes after unrelated cord blood transplantation acute myeloid leukemia

Auteurs : Vanderson Rocha ; Annalisa Ruggeri ; Stephen Spellman ; Tao Wang ; Ronald Sobecks ; Franco Locatelli ; Medhat Askar ; Gerard Michel ; William Arcese ; Anna Paola Iori ; Duncan Purtill ; Robert Danby ; Guillermo F. Sanz ; Eliane Gluckman ; Mary Eapen

Source :

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation [ 1083-8791 ] ; 2016.

RBID : PMC:4915071

Abstract

The effect of killer-cell immunoglobulin-like receptor (KIR)-ligand matching on outcomes after unrelated cord blood (CB) transplantation was studied in patients with acute myeloid leukemia (AML; n=461), categorizing KIR-ligand for HLA-C groups C1 and C2, and Bw4. Donor-recipient HLA-matching considered allele-level matching at HLA-A, -B, -C and –DRB1. Separate analyses were conducted for 6–7/8 HLA-matched and 3–5/8 HLA-matched transplants as HLA-matching confounded KIR-ligand matching (i.e., KIR-ligand mismatching was less likely with better HLA-matching). All patients received single CB unit and myeloablative conditioning. There were no significant differences in non-relapse mortality (NRM), relapse and overall mortality by KIR ligand match status. But, among recipients of 3–5/8 HLA-matched transplants, NRM (HR 2.26, p=0.008) and overall mortality (HR 1.78, p=0.008) but not relapse were higher with KIR-ligand mismatched (host vs. graft [HVG] direction) compared to KIR ligand-matched transplants. These data do not support selecting CB units based on KIR ligand match status for transplants mismatched at 1 or 2 HLA loci. Although transplants mismatched at 3 or more HLA-loci are not recommended avoiding KIR ligand mismatching in this setting lowers mortality risks.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915071

DOI: 10.1016/j.bbmt.2016.04.007
PubMed: 27090957
PubMed Central: 4915071

Links to Exploration step

PMC:4915071

Le document en format XML

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<author><name sortKey="Rocha, Vanderson" sort="Rocha, Vanderson" uniqKey="Rocha V" first="Vanderson" last="Rocha">Vanderson Rocha</name>
<affiliation><nlm:aff id="A1">Eurocord, Hôpital Saint Louis, Paris, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">Churchill Hospital and NHSBT, University of Oxford, Oxford, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ruggeri, Annalisa" sort="Ruggeri, Annalisa" uniqKey="Ruggeri A" first="Annalisa" last="Ruggeri">Annalisa Ruggeri</name>
<affiliation><nlm:aff id="A1">Eurocord, Hôpital Saint Louis, Paris, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3">Service d’Hematologie et therapie cellulaire, Hôpital Saint Antoine, Paris, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Spellman, Stephen" sort="Spellman, Stephen" uniqKey="Spellman S" first="Stephen" last="Spellman">Stephen Spellman</name>
<affiliation><nlm:aff id="A4">Center for International Blood and Marrow Transplant Research, National Marrow Donor Program, Minneapolis, MN, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wang, Tao" sort="Wang, Tao" uniqKey="Wang T" first="Tao" last="Wang">Tao Wang</name>
<affiliation><nlm:aff id="A5">Division of Biostatistics Medical College of Wisconsin, Milwaukee, WI, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sobecks, Ronald" sort="Sobecks, Ronald" uniqKey="Sobecks R" first="Ronald" last="Sobecks">Ronald Sobecks</name>
<affiliation><nlm:aff id="A6">Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Locatelli, Franco" sort="Locatelli, Franco" uniqKey="Locatelli F" first="Franco" last="Locatelli">Franco Locatelli</name>
<affiliation><nlm:aff id="A7">IRCCS Ospedale Pediatrico Bambino Gesù, Rome and University of Pavia, Pavia, Italy</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Askar, Medhat" sort="Askar, Medhat" uniqKey="Askar M" first="Medhat" last="Askar">Medhat Askar</name>
<affiliation><nlm:aff id="A8">Baylor University Medical Center, Dallas, TX, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Michel, Gerard" sort="Michel, Gerard" uniqKey="Michel G" first="Gerard" last="Michel">Gerard Michel</name>
<affiliation><nlm:aff id="A9">University Hospital of Marseille, Marseille, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Arcese, William" sort="Arcese, William" uniqKey="Arcese W" first="William" last="Arcese">William Arcese</name>
<affiliation><nlm:aff id="A10">Rome Transplant Network, University “Tor Vergata”, Rome, Italy</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Iori, Anna Paola" sort="Iori, Anna Paola" uniqKey="Iori A" first="Anna Paola" last="Iori">Anna Paola Iori</name>
<affiliation><nlm:aff id="A11">University of Rome, La Sapienza, Rome, Italy</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Purtill, Duncan" sort="Purtill, Duncan" uniqKey="Purtill D" first="Duncan" last="Purtill">Duncan Purtill</name>
<affiliation><nlm:aff id="A12">Royal Perth Hospital, Perth, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Danby, Robert" sort="Danby, Robert" uniqKey="Danby R" first="Robert" last="Danby">Robert Danby</name>
<affiliation><nlm:aff id="A2">Churchill Hospital and NHSBT, University of Oxford, Oxford, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sanz, Guillermo F" sort="Sanz, Guillermo F" uniqKey="Sanz G" first="Guillermo F." last="Sanz">Guillermo F. Sanz</name>
<affiliation><nlm:aff id="A13">Hospital Universitario La Fe, Valencia, Spain</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gluckman, Eliane" sort="Gluckman, Eliane" uniqKey="Gluckman E" first="Eliane" last="Gluckman">Eliane Gluckman</name>
<affiliation><nlm:aff id="A1">Eurocord, Hôpital Saint Louis, Paris, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A14">Monacord, Centre Scientifique de Monaco, Monaco</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Eapen, Mary" sort="Eapen, Mary" uniqKey="Eapen M" first="Mary" last="Eapen">Mary Eapen</name>
<affiliation><nlm:aff id="A15">Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA</nlm:aff>
</affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Killer cell immunoglobulin-like receptor ligand matching and outcomes after unrelated cord blood transplantation acute myeloid leukemia</title>
<author><name sortKey="Rocha, Vanderson" sort="Rocha, Vanderson" uniqKey="Rocha V" first="Vanderson" last="Rocha">Vanderson Rocha</name>
<affiliation><nlm:aff id="A1">Eurocord, Hôpital Saint Louis, Paris, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">Churchill Hospital and NHSBT, University of Oxford, Oxford, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ruggeri, Annalisa" sort="Ruggeri, Annalisa" uniqKey="Ruggeri A" first="Annalisa" last="Ruggeri">Annalisa Ruggeri</name>
<affiliation><nlm:aff id="A1">Eurocord, Hôpital Saint Louis, Paris, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3">Service d’Hematologie et therapie cellulaire, Hôpital Saint Antoine, Paris, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Spellman, Stephen" sort="Spellman, Stephen" uniqKey="Spellman S" first="Stephen" last="Spellman">Stephen Spellman</name>
<affiliation><nlm:aff id="A4">Center for International Blood and Marrow Transplant Research, National Marrow Donor Program, Minneapolis, MN, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wang, Tao" sort="Wang, Tao" uniqKey="Wang T" first="Tao" last="Wang">Tao Wang</name>
<affiliation><nlm:aff id="A5">Division of Biostatistics Medical College of Wisconsin, Milwaukee, WI, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sobecks, Ronald" sort="Sobecks, Ronald" uniqKey="Sobecks R" first="Ronald" last="Sobecks">Ronald Sobecks</name>
<affiliation><nlm:aff id="A6">Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Locatelli, Franco" sort="Locatelli, Franco" uniqKey="Locatelli F" first="Franco" last="Locatelli">Franco Locatelli</name>
<affiliation><nlm:aff id="A7">IRCCS Ospedale Pediatrico Bambino Gesù, Rome and University of Pavia, Pavia, Italy</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Askar, Medhat" sort="Askar, Medhat" uniqKey="Askar M" first="Medhat" last="Askar">Medhat Askar</name>
<affiliation><nlm:aff id="A8">Baylor University Medical Center, Dallas, TX, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Michel, Gerard" sort="Michel, Gerard" uniqKey="Michel G" first="Gerard" last="Michel">Gerard Michel</name>
<affiliation><nlm:aff id="A9">University Hospital of Marseille, Marseille, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Arcese, William" sort="Arcese, William" uniqKey="Arcese W" first="William" last="Arcese">William Arcese</name>
<affiliation><nlm:aff id="A10">Rome Transplant Network, University “Tor Vergata”, Rome, Italy</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Iori, Anna Paola" sort="Iori, Anna Paola" uniqKey="Iori A" first="Anna Paola" last="Iori">Anna Paola Iori</name>
<affiliation><nlm:aff id="A11">University of Rome, La Sapienza, Rome, Italy</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Purtill, Duncan" sort="Purtill, Duncan" uniqKey="Purtill D" first="Duncan" last="Purtill">Duncan Purtill</name>
<affiliation><nlm:aff id="A12">Royal Perth Hospital, Perth, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Danby, Robert" sort="Danby, Robert" uniqKey="Danby R" first="Robert" last="Danby">Robert Danby</name>
<affiliation><nlm:aff id="A2">Churchill Hospital and NHSBT, University of Oxford, Oxford, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sanz, Guillermo F" sort="Sanz, Guillermo F" uniqKey="Sanz G" first="Guillermo F." last="Sanz">Guillermo F. Sanz</name>
<affiliation><nlm:aff id="A13">Hospital Universitario La Fe, Valencia, Spain</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gluckman, Eliane" sort="Gluckman, Eliane" uniqKey="Gluckman E" first="Eliane" last="Gluckman">Eliane Gluckman</name>
<affiliation><nlm:aff id="A1">Eurocord, Hôpital Saint Louis, Paris, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A14">Monacord, Centre Scientifique de Monaco, Monaco</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Eapen, Mary" sort="Eapen, Mary" uniqKey="Eapen M" first="Mary" last="Eapen">Mary Eapen</name>
<affiliation><nlm:aff id="A15">Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</title>
<idno type="ISSN">1083-8791</idno>
<idno type="eISSN">1523-6536</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
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<profileDesc><textClass></textClass>
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<front><div type="abstract" xml:lang="en"><p id="P1">The effect of killer-cell immunoglobulin-like receptor (KIR)-ligand matching on outcomes after unrelated cord blood (CB) transplantation was studied in patients with acute myeloid leukemia (AML; n=461), categorizing KIR-ligand for HLA-C groups C1 and C2, and Bw4. Donor-recipient HLA-matching considered allele-level matching at HLA-A, -B, -C and –DRB1. Separate analyses were conducted for 6–7/8 HLA-matched and 3–5/8 HLA-matched transplants as HLA-matching confounded KIR-ligand matching (i.e., KIR-ligand mismatching was less likely with better HLA-matching). All patients received single CB unit and myeloablative conditioning. There were no significant differences in non-relapse mortality (NRM), relapse and overall mortality by KIR ligand match status. But, among recipients of 3–5/8 HLA-matched transplants, NRM (HR 2.26, p=0.008) and overall mortality (HR 1.78, p=0.008) but not relapse were higher with KIR-ligand mismatched (host vs. graft [HVG] direction) compared to KIR ligand-matched transplants. These data do not support selecting CB units based on KIR ligand match status for transplants mismatched at 1 or 2 HLA loci. Although transplants mismatched at 3 or more HLA-loci are not recommended avoiding KIR ligand mismatching in this setting lowers mortality risks.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">9600628</journal-id>
<journal-id journal-id-type="pubmed-jr-id">20830</journal-id>
<journal-id journal-id-type="nlm-ta">Biol Blood Marrow Transplant</journal-id>
<journal-id journal-id-type="iso-abbrev">Biol. Blood Marrow Transplant.</journal-id>
<journal-title-group><journal-title>Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</journal-title>
</journal-title-group>
<issn pub-type="ppub">1083-8791</issn>
<issn pub-type="epub">1523-6536</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">27090957</article-id>
<article-id pub-id-type="pmc">4915071</article-id>
<article-id pub-id-type="doi">10.1016/j.bbmt.2016.04.007</article-id>
<article-id pub-id-type="manuscript">NIHMS788548</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Killer cell immunoglobulin-like receptor ligand matching and outcomes after unrelated cord blood transplantation acute myeloid leukemia</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Rocha</surname>
<given-names>Vanderson</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ruggeri</surname>
<given-names>Annalisa</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Spellman</surname>
<given-names>Stephen</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Tao</given-names>
</name>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sobecks</surname>
<given-names>Ronald</given-names>
</name>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Locatelli</surname>
<given-names>Franco</given-names>
</name>
<xref ref-type="aff" rid="A7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Askar</surname>
<given-names>Medhat</given-names>
</name>
<xref ref-type="aff" rid="A8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Michel</surname>
<given-names>Gerard</given-names>
</name>
<xref ref-type="aff" rid="A9">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Arcese</surname>
<given-names>William</given-names>
</name>
<xref ref-type="aff" rid="A10">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Iori</surname>
<given-names>Anna Paola</given-names>
</name>
<xref ref-type="aff" rid="A11">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Purtill</surname>
<given-names>Duncan</given-names>
</name>
<xref ref-type="aff" rid="A12">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Danby</surname>
<given-names>Robert</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sanz</surname>
<given-names>Guillermo F.</given-names>
</name>
<xref ref-type="aff" rid="A13">13</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gluckman</surname>
<given-names>Eliane</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A14">14</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Eapen</surname>
<given-names>Mary</given-names>
</name>
<on-behalf-of>an analysis on behalf of Eurocord, Cord Blood Committee Cellular Therapy -Immunobiology Working Party of EBMT, Netcord and the Center for International Blood and Marrow Transplant Research</on-behalf-of>
<xref ref-type="aff" rid="A15">15</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Eurocord, Hôpital Saint Louis, Paris, France</aff>
<aff id="A2"><label>2</label>
Churchill Hospital and NHSBT, University of Oxford, Oxford, UK</aff>
<aff id="A3"><label>3</label>
Service d’Hematologie et therapie cellulaire, Hôpital Saint Antoine, Paris, France</aff>
<aff id="A4"><label>4</label>
Center for International Blood and Marrow Transplant Research, National Marrow Donor Program, Minneapolis, MN, USA</aff>
<aff id="A5"><label>5</label>
Division of Biostatistics Medical College of Wisconsin, Milwaukee, WI, USA</aff>
<aff id="A6"><label>6</label>
Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA</aff>
<aff id="A7"><label>7</label>
IRCCS Ospedale Pediatrico Bambino Gesù, Rome and University of Pavia, Pavia, Italy</aff>
<aff id="A8"><label>8</label>
Baylor University Medical Center, Dallas, TX, USA</aff>
<aff id="A9"><label>9</label>
University Hospital of Marseille, Marseille, France</aff>
<aff id="A10"><label>10</label>
Rome Transplant Network, University “Tor Vergata”, Rome, Italy</aff>
<aff id="A11"><label>11</label>
University of Rome, La Sapienza, Rome, Italy</aff>
<aff id="A12"><label>12</label>
Royal Perth Hospital, Perth, Australia</aff>
<aff id="A13"><label>13</label>
Hospital Universitario La Fe, Valencia, Spain</aff>
<aff id="A14"><label>14</label>
Monacord, Centre Scientifique de Monaco, Monaco</aff>
<aff id="A15"><label>15</label>
Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA</aff>
<author-notes><corresp id="cor1"><bold>Address correspondence to:</bold>
 Professor Vanderson Rocha, MD, PhD, Churchill Hospital, University of Oxford, Oxford, UK. <email>vanderson.rocha@ouh.nhs.uk</email>
; Phone: +44 1865 572326; Fax: +44 1865 235260</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>11</day>
<month>6</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub"><day>16</day>
<month>4</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="ppub"><month>7</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>7</month>
<year>2017</year>
</pub-date>
<volume>22</volume>
<issue>7</issue>
<fpage>1284</fpage>
<lpage>1289</lpage>
<pmc-comment>elocation-id from pubmed: 10.1016/j.bbmt.2016.04.007</pmc-comment>
      <abstract><p id="P1">The effect of killer-cell immunoglobulin-like receptor (KIR)-ligand matching on outcomes after unrelated cord blood (CB) transplantation was studied in patients with acute myeloid leukemia (AML; n=461), categorizing KIR-ligand for HLA-C groups C1 and C2, and Bw4. Donor-recipient HLA-matching considered allele-level matching at HLA-A, -B, -C and –DRB1. Separate analyses were conducted for 6–7/8 HLA-matched and 3–5/8 HLA-matched transplants as HLA-matching confounded KIR-ligand matching (i.e., KIR-ligand mismatching was less likely with better HLA-matching). All patients received single CB unit and myeloablative conditioning. There were no significant differences in non-relapse mortality (NRM), relapse and overall mortality by KIR ligand match status. But, among recipients of 3–5/8 HLA-matched transplants, NRM (HR 2.26, p=0.008) and overall mortality (HR 1.78, p=0.008) but not relapse were higher with KIR-ligand mismatched (host vs. graft [HVG] direction) compared to KIR ligand-matched transplants. These data do not support selecting CB units based on KIR ligand match status for transplants mismatched at 1 or 2 HLA loci. Although transplants mismatched at 3 or more HLA-loci are not recommended avoiding KIR ligand mismatching in this setting lowers mortality risks.</p>
</abstract>
<kwd-group><kwd>KIR ligand</kwd>
<kwd>unrelated transplant</kwd>
<kwd>cord blood</kwd>
<kwd>acute leukemia</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

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Killer cell immunoglobulin-like receptor ligand matching and outcomes after unrelated cord blood transplantation acute myeloid leukemia

Killer cell immunoglobulin-like receptor ligand matching and outcomes after unrelated cord blood transplantation acute myeloid leukemia

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