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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">American Society of Blood and Marrow Transplantation, European Society of Blood and Marrow Transplantation, Blood and Marrow Transplant Clinical Trials Network, and International Myeloma Working Group Consensus Conference on Salvage Hematopoietic Cell Transplantation in Patients with Relapsed Multiple Myeloma</title><author><name sortKey="Giralt, Sergio" sort="Giralt, Sergio" uniqKey="Giralt S" first="Sergio" last="Giralt">Sergio Giralt</name><affiliation><nlm:aff id="A1">Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center, New York, New York</nlm:aff></affiliation></author><author><name sortKey="Garderet, Laurent" sort="Garderet, Laurent" uniqKey="Garderet L" first="Laurent" last="Garderet">Laurent Garderet</name><affiliation><nlm:aff id="A2">Hospital St Antoine, INSERM UMR_S 938, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Durie, Brian" sort="Durie, Brian" uniqKey="Durie B" first="Brian" last="Durie">Brian Durie</name><affiliation><nlm:aff id="A3">International Myeloma Foundation, Los Angeles, California</nlm:aff></affiliation></author><author><name sortKey="Cook, Gordon" sort="Cook, Gordon" uniqKey="Cook G" first="Gordon" last="Cook">Gordon Cook</name><affiliation><nlm:aff id="A4">St. James University Hospital, Leed, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Gahrton, Gosta" sort="Gahrton, Gosta" uniqKey="Gahrton G" first="Gosta" last="Gahrton">Gosta Gahrton</name><affiliation><nlm:aff id="A5">Karolinska Institute, Huddinge, Sweden</nlm:aff></affiliation></author><author><name sortKey="Bruno, Benedetto" sort="Bruno, Benedetto" uniqKey="Bruno B" first="Benedetto" last="Bruno">Benedetto Bruno</name><affiliation><nlm:aff id="A6">Universita Degli Studi di Torini, Torino, Italy</nlm:aff></affiliation></author><author><name sortKey="Hari, Paremesweran" sort="Hari, Paremesweran" uniqKey="Hari P" first="Paremesweran" last="Hari">Paremesweran Hari</name><affiliation><nlm:aff id="A7">Medical College of Wisconsin, Milwaukee, Wisconsin</nlm:aff></affiliation></author><author><name sortKey="Lokhorst, Henk" sort="Lokhorst, Henk" uniqKey="Lokhorst H" first="Henk" last="Lokhorst">Henk Lokhorst</name><affiliation><nlm:aff id="A8">University Medical Center Utrecht, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Mccarthy, Phillip" sort="Mccarthy, Phillip" uniqKey="Mccarthy P" first="Phillip" last="Mccarthy">Phillip Mccarthy</name><affiliation><nlm:aff id="A9">Roswell Park Cancer Institute, Buffalo, New York</nlm:aff></affiliation></author><author><name sortKey="Krishnan, Amrita" sort="Krishnan, Amrita" uniqKey="Krishnan A" first="Amrita" last="Krishnan">Amrita Krishnan</name><affiliation><nlm:aff id="A10">City of Hope Cancer Center Duarte, California</nlm:aff></affiliation></author><author><name sortKey="Sonneveld, Pieter" sort="Sonneveld, Pieter" uniqKey="Sonneveld P" first="Pieter" last="Sonneveld">Pieter Sonneveld</name><affiliation><nlm:aff id="A11">Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Goldschmidt, Harmut" sort="Goldschmidt, Harmut" uniqKey="Goldschmidt H" first="Harmut" last="Goldschmidt">Harmut Goldschmidt</name><affiliation><nlm:aff id="A12">University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Jagannath, Sundar" sort="Jagannath, Sundar" uniqKey="Jagannath S" first="Sundar" last="Jagannath">Sundar Jagannath</name><affiliation><nlm:aff id="A13">Mount Sinai School of Medicine, New York, New York</nlm:aff></affiliation></author><author><name sortKey="Barlogie, Bart" sort="Barlogie, Bart" uniqKey="Barlogie B" first="Bart" last="Barlogie">Bart Barlogie</name><affiliation><nlm:aff id="A13">Mount Sinai School of Medicine, New York, New York</nlm:aff></affiliation></author><author><name sortKey="Mateos, Maria" sort="Mateos, Maria" uniqKey="Mateos M" first="Maria" last="Mateos">Maria Mateos</name><affiliation><nlm:aff id="A14">Hospital Universitario de Salamanca, Salamanca, Spain</nlm:aff></affiliation></author><author><name sortKey="Gimsing, Peter" sort="Gimsing, Peter" uniqKey="Gimsing P" first="Peter" last="Gimsing">Peter Gimsing</name><affiliation><nlm:aff id="A15">Rigshospitalet, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Sezer, Orhan" sort="Sezer, Orhan" uniqKey="Sezer O" first="Orhan" last="Sezer">Orhan Sezer</name><affiliation><nlm:aff id="A16">Memorial Sisli Hastanesi, Istanbul, Turkey</nlm:aff></affiliation></author><author><name sortKey="Mikhael, Joseph" sort="Mikhael, Joseph" uniqKey="Mikhael J" first="Joseph" last="Mikhael">Joseph Mikhael</name><affiliation><nlm:aff id="A17">Mayo Clinic Scottsdale, Scottsdale, Arizona</nlm:aff></affiliation></author><author><name sortKey="Lu, Jin" sort="Lu, Jin" uniqKey="Lu J" first="Jin" last="Lu">Jin Lu</name><affiliation><nlm:aff id="A18">Peking University Institute of Hematology, People’s Hospital, Beijing, Peoples Republic of China</nlm:aff></affiliation></author><author><name sortKey="Dimopoulos, Meletios" sort="Dimopoulos, Meletios" uniqKey="Dimopoulos M" first="Meletios" last="Dimopoulos">Meletios Dimopoulos</name><affiliation><nlm:aff id="A19">National and Kapodistrian University of Athens Alexandra Hospital, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Mazumder, Amitabha" sort="Mazumder, Amitabha" uniqKey="Mazumder A" first="Amitabha" last="Mazumder">Amitabha Mazumder</name><affiliation><nlm:aff id="A20">New York University School of Medicine, New York, New York</nlm:aff></affiliation></author><author><name sortKey="Palumbo, Antonio" sort="Palumbo, Antonio" uniqKey="Palumbo A" first="Antonio" last="Palumbo">Antonio Palumbo</name><affiliation><nlm:aff id="A21">University of Torino, Torino, Italy</nlm:aff></affiliation></author><author><name sortKey="Abonour, Rafat" sort="Abonour, Rafat" uniqKey="Abonour R" first="Rafat" last="Abonour">Rafat Abonour</name><affiliation><nlm:aff id="A22">Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana</nlm:aff></affiliation></author><author><name sortKey="Anderson, Kenneth" sort="Anderson, Kenneth" uniqKey="Anderson K" first="Kenneth" last="Anderson">Kenneth Anderson</name><affiliation><nlm:aff id="A23">Dana Farber Cancer Institute, Harvard University, Boston, Massachusetts</nlm:aff></affiliation></author><author><name sortKey="Attal, Michel" sort="Attal, Michel" uniqKey="Attal M" first="Michel" last="Attal">Michel Attal</name><affiliation><nlm:aff id="A24">Institut Claudius Regaud, Toulouse, France</nlm:aff></affiliation></author><author><name sortKey="Blade, Joan" sort="Blade, Joan" uniqKey="Blade J" first="Joan" last="Blade">Joan Blade</name><affiliation><nlm:aff id="A25">Hospital Clinic, IDIBAPS, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Bird, Jenny" sort="Bird, Jenny" uniqKey="Bird J" first="Jenny" last="Bird">Jenny Bird</name><affiliation><nlm:aff id="A26">University Hospital Bristol, Bristol, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Cavo, Michele" sort="Cavo, Michele" uniqKey="Cavo M" first="Michele" last="Cavo">Michele Cavo</name><affiliation><nlm:aff id="A27">Seragnoli Institut of Hematology, Bologna University School of Medicine, Bologna, Italy</nlm:aff></affiliation></author><author><name sortKey="Comenzo, Raymond" sort="Comenzo, Raymond" uniqKey="Comenzo R" first="Raymond" last="Comenzo">Raymond Comenzo</name><affiliation><nlm:aff id="A28">Tufts University School of Medicine, Boston, Massachusetts</nlm:aff></affiliation></author><author><name sortKey="De La Rubia, Javier" sort="De La Rubia, Javier" uniqKey="De La Rubia J" first="Javier" last="De La Rubia">Javier De La Rubia</name><affiliation><nlm:aff id="A29">Hospital Dr. Pesset, Valencia, Spain</nlm:aff></affiliation></author><author><name sortKey="Einsele, Hermann" sort="Einsele, Hermann" uniqKey="Einsele H" first="Hermann" last="Einsele">Hermann Einsele</name><affiliation><nlm:aff id="A30">Klinik der Universität Würzburg, Würzburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Garcia Sanz, Ramon" sort="Garcia Sanz, Ramon" uniqKey="Garcia Sanz R" first="Ramon" last="Garcia-Sanz">Ramon Garcia-Sanz</name><affiliation><nlm:aff id="A14">Hospital Universitario de Salamanca, Salamanca, Spain</nlm:aff></affiliation></author><author><name sortKey="Hillengass, Jens" sort="Hillengass, Jens" uniqKey="Hillengass J" first="Jens" last="Hillengass">Jens Hillengass</name><affiliation><nlm:aff id="A12">University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Holstein, Sarah" sort="Holstein, Sarah" uniqKey="Holstein S" first="Sarah" last="Holstein">Sarah Holstein</name><affiliation><nlm:aff id="A9">Roswell Park Cancer Institute, Buffalo, New York</nlm:aff></affiliation></author><author><name sortKey="Johnsen, Hans Erik" sort="Johnsen, Hans Erik" uniqKey="Johnsen H" first="Hans Erik" last="Johnsen">Hans Erik Johnsen</name><affiliation><nlm:aff id="A31">Aalborg University Hospital, Aalborg, Denmark</nlm:aff></affiliation></author><author><name sortKey="Joshua, Douglas" sort="Joshua, Douglas" uniqKey="Joshua D" first="Douglas" last="Joshua">Douglas Joshua</name><affiliation><nlm:aff id="A32">Royal Prince Alfred Hospital, Sydney University Medical School, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Koehne, Guenther" sort="Koehne, Guenther" uniqKey="Koehne G" first="Guenther" last="Koehne">Guenther Koehne</name><affiliation><nlm:aff id="A1">Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center, New York, New York</nlm:aff></affiliation></author><author><name sortKey="Kumar, Shaji" sort="Kumar, Shaji" uniqKey="Kumar S" first="Shaji" last="Kumar">Shaji Kumar</name><affiliation><nlm:aff id="A33">Mayo Clinic Rochester, Rochester, Minnesota</nlm:aff></affiliation></author><author><name sortKey="Kyle, Robert" sort="Kyle, Robert" uniqKey="Kyle R" first="Robert" last="Kyle">Robert Kyle</name><affiliation><nlm:aff id="A33">Mayo Clinic Rochester, Rochester, Minnesota</nlm:aff></affiliation></author><author><name sortKey="Leleu, Xavier" sort="Leleu, Xavier" uniqKey="Leleu X" first="Xavier" last="Leleu">Xavier Leleu</name><affiliation><nlm:aff id="A34">Hospital Claude Huriez, Lille, France</nlm:aff></affiliation></author><author><name sortKey="Lonial, Sagar" sort="Lonial, Sagar" uniqKey="Lonial S" first="Sagar" last="Lonial">Sagar Lonial</name><affiliation><nlm:aff id="A35">Emory University School of Medicine, Winship Cancer Institute, Atlanta, Georgia</nlm:aff></affiliation></author><author><name sortKey="Ludwig, Heinz" sort="Ludwig, Heinz" uniqKey="Ludwig H" first="Heinz" last="Ludwig">Heinz Ludwig</name><affiliation><nlm:aff id="A36">Wilhelminenkrebsforschungsinstituts, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Nahi, Hareth" sort="Nahi, Hareth" uniqKey="Nahi H" first="Hareth" last="Nahi">Hareth Nahi</name><affiliation><nlm:aff id="A5">Karolinska Institute, Huddinge, Sweden</nlm:aff></affiliation></author><author><name sortKey="Nooka, Anil" sort="Nooka, Anil" uniqKey="Nooka A" first="Anil" last="Nooka">Anil Nooka</name><affiliation><nlm:aff id="A35">Emory University School of Medicine, Winship Cancer Institute, Atlanta, Georgia</nlm:aff></affiliation></author><author><name sortKey="Orlowski, Robert" sort="Orlowski, Robert" uniqKey="Orlowski R" first="Robert" last="Orlowski">Robert Orlowski</name><affiliation><nlm:aff id="A37">University of Texas MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Rajkumar, Vincent" sort="Rajkumar, Vincent" uniqKey="Rajkumar V" first="Vincent" last="Rajkumar">Vincent Rajkumar</name><affiliation><nlm:aff id="A33">Mayo Clinic Rochester, Rochester, Minnesota</nlm:aff></affiliation></author><author><name sortKey="Reiman, Anthony" sort="Reiman, Anthony" uniqKey="Reiman A" first="Anthony" last="Reiman">Anthony Reiman</name><affiliation><nlm:aff id="A38">Dalhousie University Medical School, Dalhousie, Nova Scotia, Canada</nlm:aff></affiliation></author><author><name sortKey="Richardson, Paul" sort="Richardson, Paul" uniqKey="Richardson P" first="Paul" last="Richardson">Paul Richardson</name><affiliation><nlm:aff id="A23">Dana Farber Cancer Institute, Harvard University, Boston, Massachusetts</nlm:aff></affiliation></author><author><name sortKey="Riva, Eloisa" sort="Riva, Eloisa" uniqKey="Riva E" first="Eloisa" last="Riva">Eloisa Riva</name><affiliation><nlm:aff id="A39">Hospital de Clinicas, Montevideo, Uruguay</nlm:aff></affiliation></author><author><name sortKey="Miguel, Jesus San" sort="Miguel, Jesus San" uniqKey="Miguel J" first="Jesus San" last="Miguel">Jesus San Miguel</name><affiliation><nlm:aff id="A40">Clinica Universidad de Navarra, Navarra, Spain</nlm:aff></affiliation></author><author><name sortKey="Turreson, Ingemar" sort="Turreson, Ingemar" uniqKey="Turreson I" first="Ingemar" last="Turreson">Ingemar Turreson</name><affiliation><nlm:aff id="A41">Skane University Hospital, Malmo, Sweden</nlm:aff></affiliation></author><author><name sortKey="Usmani, Saad" sort="Usmani, Saad" uniqKey="Usmani S" first="Saad" last="Usmani">Saad Usmani</name><affiliation><nlm:aff id="A42">Levine Cancer Institute, Charlotte, North Carolina</nlm:aff></affiliation></author><author><name sortKey="Vesole, David" sort="Vesole, David" uniqKey="Vesole D" first="David" last="Vesole">David Vesole</name><affiliation><nlm:aff id="A43">John Theurer Cancer Center, Hackensack, New Jersey</nlm:aff></affiliation></author><author><name sortKey="Bensinger, William" sort="Bensinger, William" uniqKey="Bensinger W" first="William" last="Bensinger">William Bensinger</name><affiliation><nlm:aff id="A44">Fred Hutchinson Cancer Research Center, Seattle, Washington</nlm:aff></affiliation></author><author><name sortKey="Qazilbash, Muzaffer" sort="Qazilbash, Muzaffer" uniqKey="Qazilbash M" first="Muzaffer" last="Qazilbash">Muzaffer Qazilbash</name><affiliation><nlm:aff id="A37">University of Texas MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Efebera, Yvonne" sort="Efebera, Yvonne" uniqKey="Efebera Y" first="Yvonne" last="Efebera">Yvonne Efebera</name><affiliation><nlm:aff id="A45">Ohio State University Medical Center, Columbus, Ohio</nlm:aff></affiliation></author><author><name sortKey="Mohty, Mohamed" sort="Mohty, Mohamed" uniqKey="Mohty M" first="Mohamed" last="Mohty">Mohamed Mohty</name><affiliation><nlm:aff id="A46">University Marie and Pierre Curie, Hospital St Antoine, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Gasparreto, Christina" sort="Gasparreto, Christina" uniqKey="Gasparreto C" first="Christina" last="Gasparreto">Christina Gasparreto</name><affiliation><nlm:aff id="A47">Duke University Hospital, Durham, North Carolina</nlm:aff></affiliation></author><author><name sortKey="Gajewski, James" sort="Gajewski, James" uniqKey="Gajewski J" first="James" last="Gajewski">James Gajewski</name><affiliation><nlm:aff id="A48">Oregon Health Sciences University, Portland, Oregon</nlm:aff></affiliation></author><author><name sortKey="Lemaistre, Charles F" sort="Lemaistre, Charles F" uniqKey="Lemaistre C" first="Charles F." last="Lemaistre">Charles F. Lemaistre</name><affiliation><nlm:aff id="A49">Sarah Cannon Research Institute, Nashville, Tennesee</nlm:aff></affiliation></author><author><name sortKey="Bredeson, Chris" sort="Bredeson, Chris" uniqKey="Bredeson C" first="Chris" last="Bredeson">Chris Bredeson</name><affiliation><nlm:aff id="A50">Ottawa Hospital Research Institute, Ottawa, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Moreau, Phillipe" sort="Moreau, Phillipe" uniqKey="Moreau P" first="Phillipe" last="Moreau">Phillipe Moreau</name><affiliation><nlm:aff id="A51">University Hospital Nantes, Nantes, France</nlm:aff></affiliation></author><author><name sortKey="Pasquini, Marcelo" sort="Pasquini, Marcelo" uniqKey="Pasquini M" first="Marcelo" last="Pasquini">Marcelo Pasquini</name><affiliation><nlm:aff id="A7">Medical College of Wisconsin, Milwaukee, Wisconsin</nlm:aff></affiliation></author><author><name sortKey="Kroeger, Nicolaus" sort="Kroeger, Nicolaus" uniqKey="Kroeger N" first="Nicolaus" last="Kroeger">Nicolaus Kroeger</name><affiliation><nlm:aff id="A52">University Hospital Hamburg, Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Stadtmauer, Edward" sort="Stadtmauer, Edward" uniqKey="Stadtmauer E" first="Edward" last="Stadtmauer">Edward Stadtmauer</name><affiliation><nlm:aff id="A53">University of Pennsylvania Abramson Cancer Center, Philadelphia, Pennsylvania</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26428082</idno><idno type="pmc">4757494</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757494</idno><idno type="RBID">PMC:4757494</idno><idno type="doi">10.1016/j.bbmt.2015.09.016</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">002192</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002192</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">American Society of Blood and Marrow Transplantation, European Society of Blood and Marrow Transplantation, Blood and Marrow Transplant Clinical Trials Network, and International Myeloma Working Group Consensus Conference on Salvage Hematopoietic Cell Transplantation in Patients with Relapsed Multiple Myeloma</title><author><name sortKey="Giralt, Sergio" sort="Giralt, Sergio" uniqKey="Giralt S" first="Sergio" last="Giralt">Sergio Giralt</name><affiliation><nlm:aff id="A1">Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center, New York, New York</nlm:aff></affiliation></author><author><name sortKey="Garderet, Laurent" sort="Garderet, Laurent" uniqKey="Garderet L" first="Laurent" last="Garderet">Laurent Garderet</name><affiliation><nlm:aff id="A2">Hospital St Antoine, INSERM UMR_S 938, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Durie, Brian" sort="Durie, Brian" uniqKey="Durie B" first="Brian" last="Durie">Brian Durie</name><affiliation><nlm:aff id="A3">International Myeloma Foundation, Los Angeles, California</nlm:aff></affiliation></author><author><name sortKey="Cook, Gordon" sort="Cook, Gordon" uniqKey="Cook G" first="Gordon" last="Cook">Gordon Cook</name><affiliation><nlm:aff id="A4">St. James University Hospital, Leed, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Gahrton, Gosta" sort="Gahrton, Gosta" uniqKey="Gahrton G" first="Gosta" last="Gahrton">Gosta Gahrton</name><affiliation><nlm:aff id="A5">Karolinska Institute, Huddinge, Sweden</nlm:aff></affiliation></author><author><name sortKey="Bruno, Benedetto" sort="Bruno, Benedetto" uniqKey="Bruno B" first="Benedetto" last="Bruno">Benedetto Bruno</name><affiliation><nlm:aff id="A6">Universita Degli Studi di Torini, Torino, Italy</nlm:aff></affiliation></author><author><name sortKey="Hari, Paremesweran" sort="Hari, Paremesweran" uniqKey="Hari P" first="Paremesweran" last="Hari">Paremesweran Hari</name><affiliation><nlm:aff id="A7">Medical College of Wisconsin, Milwaukee, Wisconsin</nlm:aff></affiliation></author><author><name sortKey="Lokhorst, Henk" sort="Lokhorst, Henk" uniqKey="Lokhorst H" first="Henk" last="Lokhorst">Henk Lokhorst</name><affiliation><nlm:aff id="A8">University Medical Center Utrecht, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Mccarthy, Phillip" sort="Mccarthy, Phillip" uniqKey="Mccarthy P" first="Phillip" last="Mccarthy">Phillip Mccarthy</name><affiliation><nlm:aff id="A9">Roswell Park Cancer Institute, Buffalo, New York</nlm:aff></affiliation></author><author><name sortKey="Krishnan, Amrita" sort="Krishnan, Amrita" uniqKey="Krishnan A" first="Amrita" last="Krishnan">Amrita Krishnan</name><affiliation><nlm:aff id="A10">City of Hope Cancer Center Duarte, California</nlm:aff></affiliation></author><author><name sortKey="Sonneveld, Pieter" sort="Sonneveld, Pieter" uniqKey="Sonneveld P" first="Pieter" last="Sonneveld">Pieter Sonneveld</name><affiliation><nlm:aff id="A11">Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Goldschmidt, Harmut" sort="Goldschmidt, Harmut" uniqKey="Goldschmidt H" first="Harmut" last="Goldschmidt">Harmut Goldschmidt</name><affiliation><nlm:aff id="A12">University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Jagannath, Sundar" sort="Jagannath, Sundar" uniqKey="Jagannath S" first="Sundar" last="Jagannath">Sundar Jagannath</name><affiliation><nlm:aff id="A13">Mount Sinai School of Medicine, New York, New York</nlm:aff></affiliation></author><author><name sortKey="Barlogie, Bart" sort="Barlogie, Bart" uniqKey="Barlogie B" first="Bart" last="Barlogie">Bart Barlogie</name><affiliation><nlm:aff id="A13">Mount Sinai School of Medicine, New York, New York</nlm:aff></affiliation></author><author><name sortKey="Mateos, Maria" sort="Mateos, Maria" uniqKey="Mateos M" first="Maria" last="Mateos">Maria Mateos</name><affiliation><nlm:aff id="A14">Hospital Universitario de Salamanca, Salamanca, Spain</nlm:aff></affiliation></author><author><name sortKey="Gimsing, Peter" sort="Gimsing, Peter" uniqKey="Gimsing P" first="Peter" last="Gimsing">Peter Gimsing</name><affiliation><nlm:aff id="A15">Rigshospitalet, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Sezer, Orhan" sort="Sezer, Orhan" uniqKey="Sezer O" first="Orhan" last="Sezer">Orhan Sezer</name><affiliation><nlm:aff id="A16">Memorial Sisli Hastanesi, Istanbul, Turkey</nlm:aff></affiliation></author><author><name sortKey="Mikhael, Joseph" sort="Mikhael, Joseph" uniqKey="Mikhael J" first="Joseph" last="Mikhael">Joseph Mikhael</name><affiliation><nlm:aff id="A17">Mayo Clinic Scottsdale, Scottsdale, Arizona</nlm:aff></affiliation></author><author><name sortKey="Lu, Jin" sort="Lu, Jin" uniqKey="Lu J" first="Jin" last="Lu">Jin Lu</name><affiliation><nlm:aff id="A18">Peking University Institute of Hematology, People’s Hospital, Beijing, Peoples Republic of China</nlm:aff></affiliation></author><author><name sortKey="Dimopoulos, Meletios" sort="Dimopoulos, Meletios" uniqKey="Dimopoulos M" first="Meletios" last="Dimopoulos">Meletios Dimopoulos</name><affiliation><nlm:aff id="A19">National and Kapodistrian University of Athens Alexandra Hospital, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Mazumder, Amitabha" sort="Mazumder, Amitabha" uniqKey="Mazumder A" first="Amitabha" last="Mazumder">Amitabha Mazumder</name><affiliation><nlm:aff id="A20">New York University School of Medicine, New York, New York</nlm:aff></affiliation></author><author><name sortKey="Palumbo, Antonio" sort="Palumbo, Antonio" uniqKey="Palumbo A" first="Antonio" last="Palumbo">Antonio Palumbo</name><affiliation><nlm:aff id="A21">University of Torino, Torino, Italy</nlm:aff></affiliation></author><author><name sortKey="Abonour, Rafat" sort="Abonour, Rafat" uniqKey="Abonour R" first="Rafat" last="Abonour">Rafat Abonour</name><affiliation><nlm:aff id="A22">Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana</nlm:aff></affiliation></author><author><name sortKey="Anderson, Kenneth" sort="Anderson, Kenneth" uniqKey="Anderson K" first="Kenneth" last="Anderson">Kenneth Anderson</name><affiliation><nlm:aff id="A23">Dana Farber Cancer Institute, Harvard University, Boston, Massachusetts</nlm:aff></affiliation></author><author><name sortKey="Attal, Michel" sort="Attal, Michel" uniqKey="Attal M" first="Michel" last="Attal">Michel Attal</name><affiliation><nlm:aff id="A24">Institut Claudius Regaud, Toulouse, France</nlm:aff></affiliation></author><author><name sortKey="Blade, Joan" sort="Blade, Joan" uniqKey="Blade J" first="Joan" last="Blade">Joan Blade</name><affiliation><nlm:aff id="A25">Hospital Clinic, IDIBAPS, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Bird, Jenny" sort="Bird, Jenny" uniqKey="Bird J" first="Jenny" last="Bird">Jenny Bird</name><affiliation><nlm:aff id="A26">University Hospital Bristol, Bristol, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Cavo, Michele" sort="Cavo, Michele" uniqKey="Cavo M" first="Michele" last="Cavo">Michele Cavo</name><affiliation><nlm:aff id="A27">Seragnoli Institut of Hematology, Bologna University School of Medicine, Bologna, Italy</nlm:aff></affiliation></author><author><name sortKey="Comenzo, Raymond" sort="Comenzo, Raymond" uniqKey="Comenzo R" first="Raymond" last="Comenzo">Raymond Comenzo</name><affiliation><nlm:aff id="A28">Tufts University School of Medicine, Boston, Massachusetts</nlm:aff></affiliation></author><author><name sortKey="De La Rubia, Javier" sort="De La Rubia, Javier" uniqKey="De La Rubia J" first="Javier" last="De La Rubia">Javier De La Rubia</name><affiliation><nlm:aff id="A29">Hospital Dr. Pesset, Valencia, Spain</nlm:aff></affiliation></author><author><name sortKey="Einsele, Hermann" sort="Einsele, Hermann" uniqKey="Einsele H" first="Hermann" last="Einsele">Hermann Einsele</name><affiliation><nlm:aff id="A30">Klinik der Universität Würzburg, Würzburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Garcia Sanz, Ramon" sort="Garcia Sanz, Ramon" uniqKey="Garcia Sanz R" first="Ramon" last="Garcia-Sanz">Ramon Garcia-Sanz</name><affiliation><nlm:aff id="A14">Hospital Universitario de Salamanca, Salamanca, Spain</nlm:aff></affiliation></author><author><name sortKey="Hillengass, Jens" sort="Hillengass, Jens" uniqKey="Hillengass J" first="Jens" last="Hillengass">Jens Hillengass</name><affiliation><nlm:aff id="A12">University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Holstein, Sarah" sort="Holstein, Sarah" uniqKey="Holstein S" first="Sarah" last="Holstein">Sarah Holstein</name><affiliation><nlm:aff id="A9">Roswell Park Cancer Institute, Buffalo, New York</nlm:aff></affiliation></author><author><name sortKey="Johnsen, Hans Erik" sort="Johnsen, Hans Erik" uniqKey="Johnsen H" first="Hans Erik" last="Johnsen">Hans Erik Johnsen</name><affiliation><nlm:aff id="A31">Aalborg University Hospital, Aalborg, Denmark</nlm:aff></affiliation></author><author><name sortKey="Joshua, Douglas" sort="Joshua, Douglas" uniqKey="Joshua D" first="Douglas" last="Joshua">Douglas Joshua</name><affiliation><nlm:aff id="A32">Royal Prince Alfred Hospital, Sydney University Medical School, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Koehne, Guenther" sort="Koehne, Guenther" uniqKey="Koehne G" first="Guenther" last="Koehne">Guenther Koehne</name><affiliation><nlm:aff id="A1">Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center, New York, New York</nlm:aff></affiliation></author><author><name sortKey="Kumar, Shaji" sort="Kumar, Shaji" uniqKey="Kumar S" first="Shaji" last="Kumar">Shaji Kumar</name><affiliation><nlm:aff id="A33">Mayo Clinic Rochester, Rochester, Minnesota</nlm:aff></affiliation></author><author><name sortKey="Kyle, Robert" sort="Kyle, Robert" uniqKey="Kyle R" first="Robert" last="Kyle">Robert Kyle</name><affiliation><nlm:aff id="A33">Mayo Clinic Rochester, Rochester, Minnesota</nlm:aff></affiliation></author><author><name sortKey="Leleu, Xavier" sort="Leleu, Xavier" uniqKey="Leleu X" first="Xavier" last="Leleu">Xavier Leleu</name><affiliation><nlm:aff id="A34">Hospital Claude Huriez, Lille, France</nlm:aff></affiliation></author><author><name sortKey="Lonial, Sagar" sort="Lonial, Sagar" uniqKey="Lonial S" first="Sagar" last="Lonial">Sagar Lonial</name><affiliation><nlm:aff id="A35">Emory University School of Medicine, Winship Cancer Institute, Atlanta, Georgia</nlm:aff></affiliation></author><author><name sortKey="Ludwig, Heinz" sort="Ludwig, Heinz" uniqKey="Ludwig H" first="Heinz" last="Ludwig">Heinz Ludwig</name><affiliation><nlm:aff id="A36">Wilhelminenkrebsforschungsinstituts, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Nahi, Hareth" sort="Nahi, Hareth" uniqKey="Nahi H" first="Hareth" last="Nahi">Hareth Nahi</name><affiliation><nlm:aff id="A5">Karolinska Institute, Huddinge, Sweden</nlm:aff></affiliation></author><author><name sortKey="Nooka, Anil" sort="Nooka, Anil" uniqKey="Nooka A" first="Anil" last="Nooka">Anil Nooka</name><affiliation><nlm:aff id="A35">Emory University School of Medicine, Winship Cancer Institute, Atlanta, Georgia</nlm:aff></affiliation></author><author><name sortKey="Orlowski, Robert" sort="Orlowski, Robert" uniqKey="Orlowski R" first="Robert" last="Orlowski">Robert Orlowski</name><affiliation><nlm:aff id="A37">University of Texas MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Rajkumar, Vincent" sort="Rajkumar, Vincent" uniqKey="Rajkumar V" first="Vincent" last="Rajkumar">Vincent Rajkumar</name><affiliation><nlm:aff id="A33">Mayo Clinic Rochester, Rochester, Minnesota</nlm:aff></affiliation></author><author><name sortKey="Reiman, Anthony" sort="Reiman, Anthony" uniqKey="Reiman A" first="Anthony" last="Reiman">Anthony Reiman</name><affiliation><nlm:aff id="A38">Dalhousie University Medical School, Dalhousie, Nova Scotia, Canada</nlm:aff></affiliation></author><author><name sortKey="Richardson, Paul" sort="Richardson, Paul" uniqKey="Richardson P" first="Paul" last="Richardson">Paul Richardson</name><affiliation><nlm:aff id="A23">Dana Farber Cancer Institute, Harvard University, Boston, Massachusetts</nlm:aff></affiliation></author><author><name sortKey="Riva, Eloisa" sort="Riva, Eloisa" uniqKey="Riva E" first="Eloisa" last="Riva">Eloisa Riva</name><affiliation><nlm:aff id="A39">Hospital de Clinicas, Montevideo, Uruguay</nlm:aff></affiliation></author><author><name sortKey="Miguel, Jesus San" sort="Miguel, Jesus San" uniqKey="Miguel J" first="Jesus San" last="Miguel">Jesus San Miguel</name><affiliation><nlm:aff id="A40">Clinica Universidad de Navarra, Navarra, Spain</nlm:aff></affiliation></author><author><name sortKey="Turreson, Ingemar" sort="Turreson, Ingemar" uniqKey="Turreson I" first="Ingemar" last="Turreson">Ingemar Turreson</name><affiliation><nlm:aff id="A41">Skane University Hospital, Malmo, Sweden</nlm:aff></affiliation></author><author><name sortKey="Usmani, Saad" sort="Usmani, Saad" uniqKey="Usmani S" first="Saad" last="Usmani">Saad Usmani</name><affiliation><nlm:aff id="A42">Levine Cancer Institute, Charlotte, North Carolina</nlm:aff></affiliation></author><author><name sortKey="Vesole, David" sort="Vesole, David" uniqKey="Vesole D" first="David" last="Vesole">David Vesole</name><affiliation><nlm:aff id="A43">John Theurer Cancer Center, Hackensack, New Jersey</nlm:aff></affiliation></author><author><name sortKey="Bensinger, William" sort="Bensinger, William" uniqKey="Bensinger W" first="William" last="Bensinger">William Bensinger</name><affiliation><nlm:aff id="A44">Fred Hutchinson Cancer Research Center, Seattle, Washington</nlm:aff></affiliation></author><author><name sortKey="Qazilbash, Muzaffer" sort="Qazilbash, Muzaffer" uniqKey="Qazilbash M" first="Muzaffer" last="Qazilbash">Muzaffer Qazilbash</name><affiliation><nlm:aff id="A37">University of Texas MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Efebera, Yvonne" sort="Efebera, Yvonne" uniqKey="Efebera Y" first="Yvonne" last="Efebera">Yvonne Efebera</name><affiliation><nlm:aff id="A45">Ohio State University Medical Center, Columbus, Ohio</nlm:aff></affiliation></author><author><name sortKey="Mohty, Mohamed" sort="Mohty, Mohamed" uniqKey="Mohty M" first="Mohamed" last="Mohty">Mohamed Mohty</name><affiliation><nlm:aff id="A46">University Marie and Pierre Curie, Hospital St Antoine, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Gasparreto, Christina" sort="Gasparreto, Christina" uniqKey="Gasparreto C" first="Christina" last="Gasparreto">Christina Gasparreto</name><affiliation><nlm:aff id="A47">Duke University Hospital, Durham, North Carolina</nlm:aff></affiliation></author><author><name sortKey="Gajewski, James" sort="Gajewski, James" uniqKey="Gajewski J" first="James" last="Gajewski">James Gajewski</name><affiliation><nlm:aff id="A48">Oregon Health Sciences University, Portland, Oregon</nlm:aff></affiliation></author><author><name sortKey="Lemaistre, Charles F" sort="Lemaistre, Charles F" uniqKey="Lemaistre C" first="Charles F." last="Lemaistre">Charles F. Lemaistre</name><affiliation><nlm:aff id="A49">Sarah Cannon Research Institute, Nashville, Tennesee</nlm:aff></affiliation></author><author><name sortKey="Bredeson, Chris" sort="Bredeson, Chris" uniqKey="Bredeson C" first="Chris" last="Bredeson">Chris Bredeson</name><affiliation><nlm:aff id="A50">Ottawa Hospital Research Institute, Ottawa, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Moreau, Phillipe" sort="Moreau, Phillipe" uniqKey="Moreau P" first="Phillipe" last="Moreau">Phillipe Moreau</name><affiliation><nlm:aff id="A51">University Hospital Nantes, Nantes, France</nlm:aff></affiliation></author><author><name sortKey="Pasquini, Marcelo" sort="Pasquini, Marcelo" uniqKey="Pasquini M" first="Marcelo" last="Pasquini">Marcelo Pasquini</name><affiliation><nlm:aff id="A7">Medical College of Wisconsin, Milwaukee, Wisconsin</nlm:aff></affiliation></author><author><name sortKey="Kroeger, Nicolaus" sort="Kroeger, Nicolaus" uniqKey="Kroeger N" first="Nicolaus" last="Kroeger">Nicolaus Kroeger</name><affiliation><nlm:aff id="A52">University Hospital Hamburg, Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Stadtmauer, Edward" sort="Stadtmauer, Edward" uniqKey="Stadtmauer E" first="Edward" last="Stadtmauer">Edward Stadtmauer</name><affiliation><nlm:aff id="A53">University of Pennsylvania Abramson Cancer Center, Philadelphia, Pennsylvania</nlm:aff></affiliation></author></analytic><series><title level="j">Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</title><idno type="ISSN">1083-8791</idno><idno type="eISSN">1523-6536</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">In contrast to the upfront setting in which the role of high-dose therapy with autologous hematopoietic cell transplantation (HCT) as consolidation of a first remission in patients with multiple myeloma (MM) is well established, the role of high-dose therapy with autologous or allogeneic HCT has not been extensively studied in MM patients relapsing after primary therapy. The International Myeloma Working Group together with the Blood and Marrow Transplant Clinical Trials Network, the American Society of Blood and Marrow Transplantation, and the European Society of Blood and Marrow Transplantation convened a meeting of MM experts to: (1) summarize current knowledge regarding the role of autologous or allogeneic HCT in MM patients progressing after primary therapy, (2) propose guidelines for the use of salvage HCT in MM, (3) identify knowledge gaps, (4) propose a research agenda, and (5) develop a collaborative initiative to move the research agenda forward. After reviewing the available data, the expert committee came to the following consensus statement for salvage autologous HCT: (1) In transplantation-eligible patients relapsing after primary therapy that did NOT include an autologous HCT, high-dose therapy with HCT as part of salvage therapy should be considered standard; (2) High-dose therapy and autologous HCT should be considered appropriate therapy for any patients relapsing after primary therapy that includes an autologous HCT with initial remission duration of more than 18 months; (3) High-dose therapy and autologous HCT can be used as a bridging strategy to allogeneic HCT; (4) The role of postsalvage HCT maintenance needs to be explored in the context of well-designed prospective trials that should include new agents, such as monoclonal antibodies, immune-modulating agents, and oral proteasome inhibitors; (5) Autologous HCT consolidation should be explored as a strategy to develop novel conditioning regimens or post-HCT strategies in patients with short (less than 18 months remissions) after primary therapy; and (6) Prospective randomized trials need to be performed to define the role of salvage autologous HCT in patients with MM relapsing after primary therapy comparing it to “best non-HCT” therapy. The expert committee also underscored the importance of collecting enough hematopoietic stem cells to perform 2 transplantations early in the course of the disease. Regarding allogeneic HCT, the expert committee agreed on the following consensus statements: (1) Allogeneic HCT should be considered appropriate therapy for any eligible patient with early relapse (less than 24 months) after primary therapy that included an autologous HCT and/or high-risk features (ie, cytogenetics, extramedullary disease, plasma cell leukemia, or high lactate dehydrogenase); (2) Allogeneic HCT should be performed in the context of a clinical trial if possible; (3) The role of postallogeneic HCT maintenance therapy needs to be explored in the context of well-designed prospective trials; and (4) Prospective randomized trials need to be performed to define the role salvage allogeneic HCT in patients with MM relapsing after primary therapy.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9600628</journal-id><journal-id journal-id-type="pubmed-jr-id">20830</journal-id><journal-id journal-id-type="nlm-ta">Biol Blood Marrow Transplant</journal-id><journal-id journal-id-type="iso-abbrev">Biol. Blood Marrow Transplant.</journal-id><journal-title-group><journal-title>Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</journal-title></journal-title-group><issn pub-type="ppub">1083-8791</issn><issn pub-type="epub">1523-6536</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26428082</article-id><article-id pub-id-type="pmc">4757494</article-id><article-id pub-id-type="doi">10.1016/j.bbmt.2015.09.016</article-id><article-id pub-id-type="manuscript">NIHMS753349</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>American Society of Blood and Marrow Transplantation, European Society of Blood and Marrow Transplantation, Blood and Marrow Transplant Clinical Trials Network, and International Myeloma Working Group Consensus Conference on Salvage Hematopoietic Cell Transplantation in Patients with Relapsed Multiple Myeloma</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Giralt</surname><given-names>Sergio</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Garderet</surname><given-names>Laurent</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Durie</surname><given-names>Brian</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Cook</surname><given-names>Gordon</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Gahrton</surname><given-names>Gosta</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Bruno</surname><given-names>Benedetto</given-names></name><xref ref-type="aff" 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contrib-type="author"><name><surname>Riva</surname><given-names>Eloisa</given-names></name><xref ref-type="aff" rid="A39">39</xref></contrib><contrib contrib-type="author"><name><surname>Miguel</surname><given-names>Jesus San</given-names></name><xref ref-type="aff" rid="A40">40</xref></contrib><contrib contrib-type="author"><name><surname>Turreson</surname><given-names>Ingemar</given-names></name><xref ref-type="aff" rid="A41">41</xref></contrib><contrib contrib-type="author"><name><surname>Usmani</surname><given-names>Saad</given-names></name><xref ref-type="aff" rid="A42">42</xref></contrib><contrib contrib-type="author"><name><surname>Vesole</surname><given-names>David</given-names></name><xref ref-type="aff" rid="A43">43</xref></contrib><contrib contrib-type="author"><name><surname>Bensinger</surname><given-names>William</given-names></name><xref ref-type="aff" rid="A44">44</xref></contrib><contrib contrib-type="author"><name><surname>Qazilbash</surname><given-names>Muzaffer</given-names></name><xref ref-type="aff" rid="A37">37</xref></contrib><contrib contrib-type="author"><name><surname>Efebera</surname><given-names>Yvonne</given-names></name><xref ref-type="aff" rid="A45">45</xref></contrib><contrib contrib-type="author"><name><surname>Mohty</surname><given-names>Mohamed</given-names></name><xref ref-type="aff" rid="A46">46</xref></contrib><contrib contrib-type="author"><name><surname>Gasparreto</surname><given-names>Christina</given-names></name><xref ref-type="aff" rid="A47">47</xref></contrib><contrib contrib-type="author"><name><surname>Gajewski</surname><given-names>James</given-names></name><xref ref-type="aff" rid="A48">48</xref></contrib><contrib contrib-type="author"><name><surname>LeMaistre</surname><given-names>Charles F.</given-names></name><xref ref-type="aff" rid="A49">49</xref></contrib><contrib contrib-type="author"><name><surname>Bredeson</surname><given-names>Chris</given-names></name><xref ref-type="aff" rid="A50">50</xref></contrib><contrib contrib-type="author"><name><surname>Moreau</surname><given-names>Phillipe</given-names></name><xref ref-type="aff" rid="A51">51</xref></contrib><contrib contrib-type="author"><name><surname>Pasquini</surname><given-names>Marcelo</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Kroeger</surname><given-names>Nicolaus</given-names></name><xref ref-type="aff" rid="A52">52</xref></contrib><contrib contrib-type="author"><name><surname>Stadtmauer</surname><given-names>Edward</given-names></name><xref ref-type="aff" rid="A53">53</xref></contrib></contrib-group><aff id="A1"><label>1</label>Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center, New York, New York</aff><aff id="A2"><label>2</label>Hospital St Antoine, INSERM UMR_S 938, Paris, France</aff><aff id="A3"><label>3</label>International Myeloma Foundation, Los Angeles, California</aff><aff id="A4"><label>4</label>St. James University Hospital, Leed, United Kingdom</aff><aff id="A5"><label>5</label>Karolinska Institute, Huddinge, Sweden</aff><aff id="A6"><label>6</label>Universita Degli Studi di Torini, Torino, Italy</aff><aff id="A7"><label>7</label>Medical College of Wisconsin, Milwaukee, Wisconsin</aff><aff id="A8"><label>8</label>University Medical Center Utrecht, Netherlands</aff><aff id="A9"><label>9</label>Roswell Park Cancer Institute, Buffalo, New York</aff><aff id="A10"><label>10</label>City of Hope Cancer Center Duarte, California</aff><aff id="A11"><label>11</label>Erasmus Medical Center, Rotterdam, Netherlands</aff><aff id="A12"><label>12</label>University of Heidelberg, Heidelberg, Germany</aff><aff id="A13"><label>13</label>Mount Sinai School of Medicine, New York, New York</aff><aff id="A14"><label>14</label>Hospital Universitario de Salamanca, Salamanca, Spain</aff><aff id="A15"><label>15</label>Rigshospitalet, Copenhagen, Denmark</aff><aff id="A16"><label>16</label>Memorial Sisli Hastanesi, Istanbul, Turkey</aff><aff id="A17"><label>17</label>Mayo Clinic Scottsdale, Scottsdale, Arizona</aff><aff id="A18"><label>18</label>Peking University Institute of Hematology, People’s Hospital, Beijing, Peoples Republic of China</aff><aff id="A19"><label>19</label>National and Kapodistrian University of Athens Alexandra Hospital, Athens, Greece</aff><aff id="A20"><label>20</label>New York University School of Medicine, New York, New York</aff><aff id="A21"><label>21</label>University of Torino, Torino, Italy</aff><aff id="A22"><label>22</label>Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana</aff><aff id="A23"><label>23</label>Dana Farber Cancer Institute, Harvard University, Boston, Massachusetts</aff><aff id="A24"><label>24</label>Institut Claudius Regaud, Toulouse, France</aff><aff id="A25"><label>25</label>Hospital Clinic, IDIBAPS, Barcelona, Spain</aff><aff id="A26"><label>26</label>University Hospital Bristol, Bristol, United Kingdom</aff><aff id="A27"><label>27</label>Seragnoli Institut of Hematology, Bologna University School of Medicine, Bologna, Italy</aff><aff id="A28"><label>28</label>Tufts University School of Medicine, Boston, Massachusetts</aff><aff id="A29"><label>29</label>Hospital Dr. Pesset, Valencia, Spain</aff><aff id="A30"><label>30</label>Klinik der Universität Würzburg, Würzburg, Germany</aff><aff id="A31"><label>31</label>Aalborg University Hospital, Aalborg, Denmark</aff><aff id="A32"><label>32</label>Royal Prince Alfred Hospital, Sydney University Medical School, Sydney, Australia</aff><aff id="A33"><label>33</label>Mayo Clinic Rochester, Rochester, Minnesota</aff><aff id="A34"><label>34</label>Hospital Claude Huriez, Lille, France</aff><aff id="A35"><label>35</label>Emory University School of Medicine, Winship Cancer Institute, Atlanta, Georgia</aff><aff id="A36"><label>36</label>Wilhelminenkrebsforschungsinstituts, Vienna, Austria</aff><aff id="A37"><label>37</label>University of Texas MD Anderson Cancer Center, Houston, Texas</aff><aff id="A38"><label>38</label>Dalhousie University Medical School, Dalhousie, Nova Scotia, Canada</aff><aff id="A39"><label>39</label>Hospital de Clinicas, Montevideo, Uruguay</aff><aff id="A40"><label>40</label>Clinica Universidad de Navarra, Navarra, Spain</aff><aff id="A41"><label>41</label>Skane University Hospital, Malmo, Sweden</aff><aff id="A42"><label>42</label>Levine Cancer Institute, Charlotte, North Carolina</aff><aff id="A43"><label>43</label>John Theurer Cancer Center, Hackensack, New Jersey</aff><aff id="A44"><label>44</label>Fred Hutchinson Cancer Research Center, Seattle, Washington</aff><aff id="A45"><label>45</label>Ohio State University Medical Center, Columbus, Ohio</aff><aff id="A46"><label>46</label>University Marie and Pierre Curie, Hospital St Antoine, Paris, France</aff><aff id="A47"><label>47</label>Duke University Hospital, Durham, North Carolina</aff><aff id="A48"><label>48</label>Oregon Health Sciences University, Portland, Oregon</aff><aff id="A49"><label>49</label>Sarah Cannon Research Institute, Nashville, Tennesee</aff><aff id="A50"><label>50</label>Ottawa Hospital Research Institute, Ottawa, Ontario, Canada</aff><aff id="A51"><label>51</label>University Hospital Nantes, Nantes, France</aff><aff id="A52"><label>52</label>University Hospital Hamburg, Hamburg, Germany</aff><aff id="A53"><label>53</label>University of Pennsylvania Abramson Cancer Center, Philadelphia, Pennsylvania</aff><author-notes><corresp id="FN1"><label>*</label>Correspondence and reprint requests: Sergio Giralt, MD, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 235, New York, NY 10065. <email>giralts@mskcc.org</email> (S. Giralt)</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>25</day><month>1</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>30</day><month>9</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>12</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>17</day><month>2</month><year>2016</year></pub-date><volume>21</volume><issue>12</issue><fpage>2039</fpage><lpage>2051</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.bbmt.2015.09.016</pmc-comment>
<abstract><p id="P1">In contrast to the upfront setting in which the role of high-dose therapy with autologous hematopoietic cell transplantation (HCT) as consolidation of a first remission in patients with multiple myeloma (MM) is well established, the role of high-dose therapy with autologous or allogeneic HCT has not been extensively studied in MM patients relapsing after primary therapy. The International Myeloma Working Group together with the Blood and Marrow Transplant Clinical Trials Network, the American Society of Blood and Marrow Transplantation, and the European Society of Blood and Marrow Transplantation convened a meeting of MM experts to: (1) summarize current knowledge regarding the role of autologous or allogeneic HCT in MM patients progressing after primary therapy, (2) propose guidelines for the use of salvage HCT in MM, (3) identify knowledge gaps, (4) propose a research agenda, and (5) develop a collaborative initiative to move the research agenda forward. After reviewing the available data, the expert committee came to the following consensus statement for salvage autologous HCT: (1) In transplantation-eligible patients relapsing after primary therapy that did NOT include an autologous HCT, high-dose therapy with HCT as part of salvage therapy should be considered standard; (2) High-dose therapy and autologous HCT should be considered appropriate therapy for any patients relapsing after primary therapy that includes an autologous HCT with initial remission duration of more than 18 months; (3) High-dose therapy and autologous HCT can be used as a bridging strategy to allogeneic HCT; (4) The role of postsalvage HCT maintenance needs to be explored in the context of well-designed prospective trials that should include new agents, such as monoclonal antibodies, immune-modulating agents, and oral proteasome inhibitors; (5) Autologous HCT consolidation should be explored as a strategy to develop novel conditioning regimens or post-HCT strategies in patients with short (less than 18 months remissions) after primary therapy; and (6) Prospective randomized trials need to be performed to define the role of salvage autologous HCT in patients with MM relapsing after primary therapy comparing it to “best non-HCT” therapy. The expert committee also underscored the importance of collecting enough hematopoietic stem cells to perform 2 transplantations early in the course of the disease. Regarding allogeneic HCT, the expert committee agreed on the following consensus statements: (1) Allogeneic HCT should be considered appropriate therapy for any eligible patient with early relapse (less than 24 months) after primary therapy that included an autologous HCT and/or high-risk features (ie, cytogenetics, extramedullary disease, plasma cell leukemia, or high lactate dehydrogenase); (2) Allogeneic HCT should be performed in the context of a clinical trial if possible; (3) The role of postallogeneic HCT maintenance therapy needs to be explored in the context of well-designed prospective trials; and (4) Prospective randomized trials need to be performed to define the role salvage allogeneic HCT in patients with MM relapsing after primary therapy.</p></abstract><kwd-group><kwd>Myeloma</kwd><kwd>Stem cell transplantation</kwd><kwd>Salvage therapy</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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