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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">THE IMPACT OF GRAFT VERSUS HOST DISEASE ON RELAPSE RATE IN PATIENTS WITH LYMPHOMA DEPENDS ON THE HISTOLOGICAL SUB-TYPE AND THE INTENSITY OF THE CONDITIONING REGIMEN</title>
<author><name sortKey="Urbano Ispizua, Alvaro" sort="Urbano Ispizua, Alvaro" uniqKey="Urbano Ispizua A" first="Alvaro" last="Urbano-Ispizua">Alvaro Urbano-Ispizua</name>
<affiliation><nlm:aff id="A1">Department of Hematology, Hospital Clinic, University of Barcelona, IDIBAPS, and Institute of Research Josep Carreras, Barcelona, Spain</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pavletic, Steven Z" sort="Pavletic, Steven Z" uniqKey="Pavletic S" first="Steven Z." last="Pavletic">Steven Z. Pavletic</name>
<affiliation><nlm:aff id="A2">Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Flowers, Mary E" sort="Flowers, Mary E" uniqKey="Flowers M" first="Mary E." last="Flowers">Mary E. Flowers</name>
<affiliation><nlm:aff id="A3">Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Klein, John P" sort="Klein, John P" uniqKey="Klein J" first="John P." last="Klein">John P. Klein</name>
<affiliation><nlm:aff id="A4">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A5">Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zhang, Mei Jie" sort="Zhang, Mei Jie" uniqKey="Zhang M" first="Mei-Jie" last="Zhang">Mei-Jie Zhang</name>
<affiliation><nlm:aff id="A4">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A5">Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Carreras, Jeanette" sort="Carreras, Jeanette" uniqKey="Carreras J" first="Jeanette" last="Carreras">Jeanette Carreras</name>
<affiliation><nlm:aff id="A4">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Montoto, Silvia" sort="Montoto, Silvia" uniqKey="Montoto S" first="Silvia" last="Montoto">Silvia Montoto</name>
<affiliation><nlm:aff id="A6">Department of Haemato-oncology, St. Bartholomew's Hospital, Barts Health NHS Trust, London, United Kingdom</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Perales, Miguel Angel" sort="Perales, Miguel Angel" uniqKey="Perales M" first="Miguel-Angel" last="Perales">Miguel-Angel Perales</name>
<affiliation><nlm:aff id="A7">Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Aljurf, Mahmoud D" sort="Aljurf, Mahmoud D" uniqKey="Aljurf M" first="Mahmoud D." last="Aljurf">Mahmoud D. Aljurf</name>
<affiliation><nlm:aff id="A8"> Department of Oncology, King Faisal Specialist Hospital Center & Research, Riyadh, Saudi Arabia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Akpek, Gorgun" sort="Akpek, Gorgun" uniqKey="Akpek G" first="Görgün" last="Akpek">Görgün Akpek</name>
<affiliation><nlm:aff id="A9">Section of Hematology Oncology, Banner MD Anderson Cancer Center, Gilbert, AZ</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bredeson, Christopher N" sort="Bredeson, Christopher N" uniqKey="Bredeson C" first="Christopher N." last="Bredeson">Christopher N. Bredeson</name>
<affiliation><nlm:aff id="A10">The Ottawa Hospital Blood and Marrow Transplant Program and the Ottawa Hospital Research Institute, Ottawa, ON, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Costa, Luciano J" sort="Costa, Luciano J" uniqKey="Costa L" first="Luciano J." last="Costa">Luciano J. Costa</name>
<affiliation><nlm:aff id="A11">Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dandoy, Christopher" sort="Dandoy, Christopher" uniqKey="Dandoy C" first="Christopher" last="Dandoy">Christopher Dandoy</name>
<affiliation><nlm:aff id="A12">Cincinnati Children's Hospital Medical Center, Cincinnati, OH</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Freytes, Cesar O" sort="Freytes, Cesar O" uniqKey="Freytes C" first="César O." last="Freytes">César O. Freytes</name>
<affiliation><nlm:aff id="A13">South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio, TX</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fung, Henry C" sort="Fung, Henry C" uniqKey="Fung H" first="Henry C." last="Fung">Henry C. Fung</name>
<affiliation><nlm:aff id="A14"> Department of Medical Oncology, Fox Chase Cancer Center, Temple Health, Philadelphia, PA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gale, Robert Peter" sort="Gale, Robert Peter" uniqKey="Gale R" first="Robert Peter" last="Gale">Robert Peter Gale</name>
<affiliation><nlm:aff id="A15">Hematology Research Centre, Division of Experimental Medicine, Department of Medicine, Imperial College London, London, United Kingdom</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gibson, John" sort="Gibson, John" uniqKey="Gibson J" first="John" last="Gibson">John Gibson</name>
<affiliation><nlm:aff id="A16">Institute of Haematology, Royal Prince Alfred Hospital, Camperdown, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hamadani, Mehdi" sort="Hamadani, Mehdi" uniqKey="Hamadani M" first="Mehdi" last="Hamadani">Mehdi Hamadani</name>
<affiliation><nlm:aff id="A4">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hayashi, Robert J" sort="Hayashi, Robert J" uniqKey="Hayashi R" first="Robert J." last="Hayashi">Robert J. Hayashi</name>
<affiliation><nlm:aff id="A17">Division of Pediatric Hematology/Oncology, Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Inamoto, Yoshihiro" sort="Inamoto, Yoshihiro" uniqKey="Inamoto Y" first="Yoshihiro" last="Inamoto">Yoshihiro Inamoto</name>
<affiliation><nlm:aff id="A3">Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Inwards, David J" sort="Inwards, David J" uniqKey="Inwards D" first="David J." last="Inwards">David J. Inwards</name>
<affiliation><nlm:aff id="A18">Division of Hematology, Mayo Clinic, Rochester, MN</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lazarus, Hillard M" sort="Lazarus, Hillard M" uniqKey="Lazarus H" first="Hillard M." last="Lazarus">Hillard M. Lazarus</name>
<affiliation><nlm:aff id="A19">Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Maloney, David G" sort="Maloney, David G" uniqKey="Maloney D" first="David G." last="Maloney">David G. Maloney</name>
<affiliation><nlm:aff id="A3">Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Martino, Rodrigo" sort="Martino, Rodrigo" uniqKey="Martino R" first="Rodrigo" last="Martino">Rodrigo Martino</name>
<affiliation><nlm:aff id="A20">Divison of Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Munker, Reinhold" sort="Munker, Reinhold" uniqKey="Munker R" first="Reinhold" last="Munker">Reinhold Munker</name>
<affiliation><nlm:aff id="A21">Divison of Hematology/Oncology, Department of Internal Medicine, Louisiana State University Health Shreveport, LA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nishihori, Taiga" sort="Nishihori, Taiga" uniqKey="Nishihori T" first="Taiga" last="Nishihori">Taiga Nishihori</name>
<affiliation><nlm:aff id="A22"> Department of Medical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Olsson, Richard F" sort="Olsson, Richard F" uniqKey="Olsson R" first="Richard F." last="Olsson">Richard F. Olsson</name>
<affiliation><nlm:aff id="A23">Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A24">Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rizzieri, David A" sort="Rizzieri, David A" uniqKey="Rizzieri D" first="David A." last="Rizzieri">David A. Rizzieri</name>
<affiliation><nlm:aff id="A25">Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, NC</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Reshef, Ran" sort="Reshef, Ran" uniqKey="Reshef R" first="Ran" last="Reshef">Ran Reshef</name>
<affiliation><nlm:aff id="A26">Department of Medicine, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Saad, Ayman" sort="Saad, Ayman" uniqKey="Saad A" first="Ayman" last="Saad">Ayman Saad</name>
<affiliation><nlm:aff id="A8"> Department of Oncology, King Faisal Specialist Hospital Center & Research, Riyadh, Saudi Arabia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N." last="Savani">Bipin N. Savani</name>
<affiliation><nlm:aff id="A27">Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schouten, Harry C" sort="Schouten, Harry C" uniqKey="Schouten H" first="Harry C." last="Schouten">Harry C. Schouten</name>
<affiliation><nlm:aff id="A28">Department of Hematology, Academische Ziekenhuis, Maastricht, Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Smith, Sonali M" sort="Smith, Sonali M" uniqKey="Smith S" first="Sonali M." last="Smith">Sonali M. Smith</name>
<affiliation><nlm:aff id="A29">Section of Hematology/Oncology, The University of Chicago, IL</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Socie, Gerard" sort="Socie, Gerard" uniqKey="Socie G" first="Gérard" last="Socié">Gérard Socié</name>
<affiliation><nlm:aff id="A30">Department of Hematology, Hôpital Saint Louis, Paris, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wirk, Baldeep" sort="Wirk, Baldeep" uniqKey="Wirk B" first="Baldeep" last="Wirk">Baldeep Wirk</name>
<affiliation><nlm:aff id="A31">Department of Internal Medicine, Stony Brook University Medical Center, Stony Brook, NY</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yu, Lolie C" sort="Yu, Lolie C" uniqKey="Yu L" first="Lolie C." last="Yu">Lolie C. Yu</name>
<affiliation><nlm:aff id="A32">Division of Hematology/Oncology, Center for Cancer and Blood Disorders, Children's Hospital/Louisiana State University Medical Center, New Orleans, LA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name>
<affiliation><nlm:aff id="A4">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25981509</idno>
<idno type="pmc">4568162</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568162</idno>
<idno type="RBID">PMC:4568162</idno>
<idno type="doi">10.1016/j.bbmt.2015.05.010</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">002191</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002191</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">THE IMPACT OF GRAFT VERSUS HOST DISEASE ON RELAPSE RATE IN PATIENTS WITH LYMPHOMA DEPENDS ON THE HISTOLOGICAL SUB-TYPE AND THE INTENSITY OF THE CONDITIONING REGIMEN</title>
<author><name sortKey="Urbano Ispizua, Alvaro" sort="Urbano Ispizua, Alvaro" uniqKey="Urbano Ispizua A" first="Alvaro" last="Urbano-Ispizua">Alvaro Urbano-Ispizua</name>
<affiliation><nlm:aff id="A1">Department of Hematology, Hospital Clinic, University of Barcelona, IDIBAPS, and Institute of Research Josep Carreras, Barcelona, Spain</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pavletic, Steven Z" sort="Pavletic, Steven Z" uniqKey="Pavletic S" first="Steven Z." last="Pavletic">Steven Z. Pavletic</name>
<affiliation><nlm:aff id="A2">Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Flowers, Mary E" sort="Flowers, Mary E" uniqKey="Flowers M" first="Mary E." last="Flowers">Mary E. Flowers</name>
<affiliation><nlm:aff id="A3">Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Klein, John P" sort="Klein, John P" uniqKey="Klein J" first="John P." last="Klein">John P. Klein</name>
<affiliation><nlm:aff id="A4">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A5">Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zhang, Mei Jie" sort="Zhang, Mei Jie" uniqKey="Zhang M" first="Mei-Jie" last="Zhang">Mei-Jie Zhang</name>
<affiliation><nlm:aff id="A4">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A5">Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Carreras, Jeanette" sort="Carreras, Jeanette" uniqKey="Carreras J" first="Jeanette" last="Carreras">Jeanette Carreras</name>
<affiliation><nlm:aff id="A4">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Montoto, Silvia" sort="Montoto, Silvia" uniqKey="Montoto S" first="Silvia" last="Montoto">Silvia Montoto</name>
<affiliation><nlm:aff id="A6">Department of Haemato-oncology, St. Bartholomew's Hospital, Barts Health NHS Trust, London, United Kingdom</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Perales, Miguel Angel" sort="Perales, Miguel Angel" uniqKey="Perales M" first="Miguel-Angel" last="Perales">Miguel-Angel Perales</name>
<affiliation><nlm:aff id="A7">Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Aljurf, Mahmoud D" sort="Aljurf, Mahmoud D" uniqKey="Aljurf M" first="Mahmoud D." last="Aljurf">Mahmoud D. Aljurf</name>
<affiliation><nlm:aff id="A8"> Department of Oncology, King Faisal Specialist Hospital Center & Research, Riyadh, Saudi Arabia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Akpek, Gorgun" sort="Akpek, Gorgun" uniqKey="Akpek G" first="Görgün" last="Akpek">Görgün Akpek</name>
<affiliation><nlm:aff id="A9">Section of Hematology Oncology, Banner MD Anderson Cancer Center, Gilbert, AZ</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bredeson, Christopher N" sort="Bredeson, Christopher N" uniqKey="Bredeson C" first="Christopher N." last="Bredeson">Christopher N. Bredeson</name>
<affiliation><nlm:aff id="A10">The Ottawa Hospital Blood and Marrow Transplant Program and the Ottawa Hospital Research Institute, Ottawa, ON, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Costa, Luciano J" sort="Costa, Luciano J" uniqKey="Costa L" first="Luciano J." last="Costa">Luciano J. Costa</name>
<affiliation><nlm:aff id="A11">Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dandoy, Christopher" sort="Dandoy, Christopher" uniqKey="Dandoy C" first="Christopher" last="Dandoy">Christopher Dandoy</name>
<affiliation><nlm:aff id="A12">Cincinnati Children's Hospital Medical Center, Cincinnati, OH</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Freytes, Cesar O" sort="Freytes, Cesar O" uniqKey="Freytes C" first="César O." last="Freytes">César O. Freytes</name>
<affiliation><nlm:aff id="A13">South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio, TX</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fung, Henry C" sort="Fung, Henry C" uniqKey="Fung H" first="Henry C." last="Fung">Henry C. Fung</name>
<affiliation><nlm:aff id="A14"> Department of Medical Oncology, Fox Chase Cancer Center, Temple Health, Philadelphia, PA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gale, Robert Peter" sort="Gale, Robert Peter" uniqKey="Gale R" first="Robert Peter" last="Gale">Robert Peter Gale</name>
<affiliation><nlm:aff id="A15">Hematology Research Centre, Division of Experimental Medicine, Department of Medicine, Imperial College London, London, United Kingdom</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gibson, John" sort="Gibson, John" uniqKey="Gibson J" first="John" last="Gibson">John Gibson</name>
<affiliation><nlm:aff id="A16">Institute of Haematology, Royal Prince Alfred Hospital, Camperdown, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hamadani, Mehdi" sort="Hamadani, Mehdi" uniqKey="Hamadani M" first="Mehdi" last="Hamadani">Mehdi Hamadani</name>
<affiliation><nlm:aff id="A4">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hayashi, Robert J" sort="Hayashi, Robert J" uniqKey="Hayashi R" first="Robert J." last="Hayashi">Robert J. Hayashi</name>
<affiliation><nlm:aff id="A17">Division of Pediatric Hematology/Oncology, Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Inamoto, Yoshihiro" sort="Inamoto, Yoshihiro" uniqKey="Inamoto Y" first="Yoshihiro" last="Inamoto">Yoshihiro Inamoto</name>
<affiliation><nlm:aff id="A3">Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Inwards, David J" sort="Inwards, David J" uniqKey="Inwards D" first="David J." last="Inwards">David J. Inwards</name>
<affiliation><nlm:aff id="A18">Division of Hematology, Mayo Clinic, Rochester, MN</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lazarus, Hillard M" sort="Lazarus, Hillard M" uniqKey="Lazarus H" first="Hillard M." last="Lazarus">Hillard M. Lazarus</name>
<affiliation><nlm:aff id="A19">Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Maloney, David G" sort="Maloney, David G" uniqKey="Maloney D" first="David G." last="Maloney">David G. Maloney</name>
<affiliation><nlm:aff id="A3">Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Martino, Rodrigo" sort="Martino, Rodrigo" uniqKey="Martino R" first="Rodrigo" last="Martino">Rodrigo Martino</name>
<affiliation><nlm:aff id="A20">Divison of Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Munker, Reinhold" sort="Munker, Reinhold" uniqKey="Munker R" first="Reinhold" last="Munker">Reinhold Munker</name>
<affiliation><nlm:aff id="A21">Divison of Hematology/Oncology, Department of Internal Medicine, Louisiana State University Health Shreveport, LA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nishihori, Taiga" sort="Nishihori, Taiga" uniqKey="Nishihori T" first="Taiga" last="Nishihori">Taiga Nishihori</name>
<affiliation><nlm:aff id="A22"> Department of Medical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Olsson, Richard F" sort="Olsson, Richard F" uniqKey="Olsson R" first="Richard F." last="Olsson">Richard F. Olsson</name>
<affiliation><nlm:aff id="A23">Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A24">Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rizzieri, David A" sort="Rizzieri, David A" uniqKey="Rizzieri D" first="David A." last="Rizzieri">David A. Rizzieri</name>
<affiliation><nlm:aff id="A25">Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, NC</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Reshef, Ran" sort="Reshef, Ran" uniqKey="Reshef R" first="Ran" last="Reshef">Ran Reshef</name>
<affiliation><nlm:aff id="A26">Department of Medicine, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Saad, Ayman" sort="Saad, Ayman" uniqKey="Saad A" first="Ayman" last="Saad">Ayman Saad</name>
<affiliation><nlm:aff id="A8"> Department of Oncology, King Faisal Specialist Hospital Center & Research, Riyadh, Saudi Arabia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N." last="Savani">Bipin N. Savani</name>
<affiliation><nlm:aff id="A27">Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schouten, Harry C" sort="Schouten, Harry C" uniqKey="Schouten H" first="Harry C." last="Schouten">Harry C. Schouten</name>
<affiliation><nlm:aff id="A28">Department of Hematology, Academische Ziekenhuis, Maastricht, Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Smith, Sonali M" sort="Smith, Sonali M" uniqKey="Smith S" first="Sonali M." last="Smith">Sonali M. Smith</name>
<affiliation><nlm:aff id="A29">Section of Hematology/Oncology, The University of Chicago, IL</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Socie, Gerard" sort="Socie, Gerard" uniqKey="Socie G" first="Gérard" last="Socié">Gérard Socié</name>
<affiliation><nlm:aff id="A30">Department of Hematology, Hôpital Saint Louis, Paris, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wirk, Baldeep" sort="Wirk, Baldeep" uniqKey="Wirk B" first="Baldeep" last="Wirk">Baldeep Wirk</name>
<affiliation><nlm:aff id="A31">Department of Internal Medicine, Stony Brook University Medical Center, Stony Brook, NY</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yu, Lolie C" sort="Yu, Lolie C" uniqKey="Yu L" first="Lolie C." last="Yu">Lolie C. Yu</name>
<affiliation><nlm:aff id="A32">Division of Hematology/Oncology, Center for Cancer and Blood Disorders, Children's Hospital/Louisiana State University Medical Center, New Orleans, LA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name>
<affiliation><nlm:aff id="A4">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</title>
<idno type="ISSN">1083-8791</idno>
<idno type="eISSN">1523-6536</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title>
<p id="P1">To analyze the impact of graft versus host disease (GVHD) on the relapse rate of different lymphoma subtypes after allogeneic hematopoietic cell transplantation (allo-HCT).</p>
</sec>
<sec id="S2"><title>Patients and Methods</title>
<p id="P2">Adult patients with a diagnosis of Hodgkin lymphoma (HL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), peripheral T-cell lymphoma (PTCL), or mantle cell lymphoma (MCL) undergoing HLA-identical sibling or unrelated donor HCT between 1997 and 2009 were included.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Two thousand six hundred and eleven cases were included. Reduced-intensity conditioning (RIC) regimen was used in 62.8% of the transplants. In a multivariate analysis of myeloablative cases (n=970), neither acute (aGVHD) nor chronic GVHD (cGVHD) were significantly associated with a lower incidence of relapse/progression in any lymphoma subtype. In contrast, the analysis of RIC cases (n=1641) showed that cGVHD was associated with a lower incidence of relapse/progression in FL (RR 0.51, p=0.049) and in MCL (RR 0.41, p=0.019). Patients with FL or MCL developing both aGVHD and cGVHD had the lowest risk of relapse (RR 0.14, p=0.007; and RR 0.15, p=0.0019, respectively). Of interest, the effect of GVHD on decreasing relapse was similar in patients with sensitive disease and chemoresistant disease. Unfortunately, both aGVHD and cGVHD had a deleterious effect on treatment related mortality (TRM) and overall survival (OS) in FL cases, and did not impact TRM, OS or PFS in MCL.</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">This study reinforces the use of RIC allo-HCT as a platform for immunotherapy in follicular and mantle cell lymphoma patients.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9600628</journal-id>
<journal-id journal-id-type="pubmed-jr-id">20830</journal-id>
<journal-id journal-id-type="nlm-ta">Biol Blood Marrow Transplant</journal-id>
<journal-id journal-id-type="iso-abbrev">Biol. Blood Marrow Transplant.</journal-id>
<journal-title-group><journal-title>Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</journal-title>
</journal-title-group>
<issn pub-type="ppub">1083-8791</issn>
<issn pub-type="epub">1523-6536</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25981509</article-id>
<article-id pub-id-type="pmc">4568162</article-id>
<article-id pub-id-type="doi">10.1016/j.bbmt.2015.05.010</article-id>
<article-id pub-id-type="manuscript">NIHMS699346</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>THE IMPACT OF GRAFT VERSUS HOST DISEASE ON RELAPSE RATE IN PATIENTS WITH LYMPHOMA DEPENDS ON THE HISTOLOGICAL SUB-TYPE AND THE INTENSITY OF THE CONDITIONING REGIMEN</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Urbano-Ispizua</surname>
<given-names>Alvaro</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pavletic</surname>
<given-names>Steven Z.</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Flowers</surname>
<given-names>Mary E.</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Klein</surname>
<given-names>John P.</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zhang</surname>
<given-names>Mei-Jie</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Carreras</surname>
<given-names>Jeanette</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Montoto</surname>
<given-names>Silvia</given-names>
</name>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Perales</surname>
<given-names>Miguel-Angel</given-names>
</name>
<xref ref-type="aff" rid="A7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Aljurf</surname>
<given-names>Mahmoud D.</given-names>
</name>
<xref ref-type="aff" rid="A8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Akpek</surname>
<given-names>Görgün</given-names>
</name>
<xref ref-type="aff" rid="A9">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bredeson</surname>
<given-names>Christopher N.</given-names>
</name>
<xref ref-type="aff" rid="A10">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Costa</surname>
<given-names>Luciano J.</given-names>
</name>
<xref ref-type="aff" rid="A11">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dandoy</surname>
<given-names>Christopher</given-names>
</name>
<xref ref-type="aff" rid="A12">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Freytes</surname>
<given-names>César O.</given-names>
</name>
<xref ref-type="aff" rid="A13">13</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fung</surname>
<given-names>Henry C.</given-names>
</name>
<xref ref-type="aff" rid="A14">14</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gale</surname>
<given-names>Robert Peter</given-names>
</name>
<xref ref-type="aff" rid="A15">15</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gibson</surname>
<given-names>John</given-names>
</name>
<xref ref-type="aff" rid="A16">16</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hamadani</surname>
<given-names>Mehdi</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hayashi</surname>
<given-names>Robert J.</given-names>
</name>
<xref ref-type="aff" rid="A17">17</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Inamoto</surname>
<given-names>Yoshihiro</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Inwards</surname>
<given-names>David J.</given-names>
</name>
<xref ref-type="aff" rid="A18">18</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lazarus</surname>
<given-names>Hillard M.</given-names>
</name>
<xref ref-type="aff" rid="A19">19</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Maloney</surname>
<given-names>David G.</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Martino</surname>
<given-names>Rodrigo</given-names>
</name>
<xref ref-type="aff" rid="A20">20</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Munker</surname>
<given-names>Reinhold</given-names>
</name>
<xref ref-type="aff" rid="A21">21</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nishihori</surname>
<given-names>Taiga</given-names>
</name>
<xref ref-type="aff" rid="A22">22</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Olsson</surname>
<given-names>Richard F.</given-names>
</name>
<xref ref-type="aff" rid="A23">23</xref>
<xref ref-type="aff" rid="A24">24</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rizzieri</surname>
<given-names>David A.</given-names>
</name>
<xref ref-type="aff" rid="A25">25</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Reshef</surname>
<given-names>Ran</given-names>
</name>
<xref ref-type="aff" rid="A26">26</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Saad</surname>
<given-names>Ayman</given-names>
</name>
<xref ref-type="aff" rid="A8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Savani</surname>
<given-names>Bipin N.</given-names>
</name>
<xref ref-type="aff" rid="A27">27</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schouten</surname>
<given-names>Harry C.</given-names>
</name>
<xref ref-type="aff" rid="A28">28</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Smith</surname>
<given-names>Sonali M.</given-names>
</name>
<xref ref-type="aff" rid="A29">29</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Socié</surname>
<given-names>Gérard</given-names>
</name>
<xref ref-type="aff" rid="A30">30</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wirk</surname>
<given-names>Baldeep</given-names>
</name>
<xref ref-type="aff" rid="A31">31</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yu</surname>
<given-names>Lolie C.</given-names>
</name>
<xref ref-type="aff" rid="A32">32</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Saber</surname>
<given-names>Wael</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Department of Hematology, Hospital Clinic, University of Barcelona, IDIBAPS, and Institute of Research Josep Carreras, Barcelona, Spain</aff>
<aff id="A2"><label>2</label>
Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD</aff>
<aff id="A3"><label>3</label>
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA</aff>
<aff id="A4"><label>4</label>
Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</aff>
<aff id="A5"><label>5</label>
Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI</aff>
<aff id="A6"><label>6</label>
Department of Haemato-oncology, St. Bartholomew's Hospital, Barts Health NHS Trust, London, United Kingdom</aff>
<aff id="A7"><label>7</label>
Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY</aff>
<aff id="A8"><label>8</label>
Department of Oncology, King Faisal Specialist Hospital Center & Research, Riyadh, Saudi Arabia</aff>
<aff id="A9"><label>9</label>
Section of Hematology Oncology, Banner MD Anderson Cancer Center, Gilbert, AZ</aff>
<aff id="A10"><label>10</label>
The Ottawa Hospital Blood and Marrow Transplant Program and the Ottawa Hospital Research Institute, Ottawa, ON, Canada</aff>
<aff id="A11"><label>11</label>
Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL</aff>
<aff id="A12"><label>12</label>
Cincinnati Children's Hospital Medical Center, Cincinnati, OH</aff>
<aff id="A13"><label>13</label>
South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio, TX</aff>
<aff id="A14"><label>14</label>
Department of Medical Oncology, Fox Chase Cancer Center, Temple Health, Philadelphia, PA</aff>
<aff id="A15"><label>15</label>
Hematology Research Centre, Division of Experimental Medicine, Department of Medicine, Imperial College London, London, United Kingdom</aff>
<aff id="A16"><label>16</label>
Institute of Haematology, Royal Prince Alfred Hospital, Camperdown, Australia</aff>
<aff id="A17"><label>17</label>
Division of Pediatric Hematology/Oncology, Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO</aff>
<aff id="A18"><label>18</label>
Division of Hematology, Mayo Clinic, Rochester, MN</aff>
<aff id="A19"><label>19</label>
Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH</aff>
<aff id="A20"><label>20</label>
Divison of Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain</aff>
<aff id="A21"><label>21</label>
Divison of Hematology/Oncology, Department of Internal Medicine, Louisiana State University Health Shreveport, LA</aff>
<aff id="A22"><label>22</label>
Department of Medical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL</aff>
<aff id="A23"><label>23</label>
Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden</aff>
<aff id="A24"><label>24</label>
Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden</aff>
<aff id="A25"><label>25</label>
Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, NC</aff>
<aff id="A26"><label>26</label>
Department of Medicine, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA</aff>
<aff id="A27"><label>27</label>
Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN</aff>
<aff id="A28"><label>28</label>
Department of Hematology, Academische Ziekenhuis, Maastricht, Netherlands</aff>
<aff id="A29"><label>29</label>
Section of Hematology/Oncology, The University of Chicago, IL</aff>
<aff id="A30"><label>30</label>
Department of Hematology, Hôpital Saint Louis, Paris, France</aff>
<aff id="A31"><label>31</label>
Department of Internal Medicine, Stony Brook University Medical Center, Stony Brook, NY</aff>
<aff id="A32"><label>32</label>
Division of Hematology/Oncology, Center for Cancer and Blood Disorders, Children's Hospital/Louisiana State University Medical Center, New Orleans, LA</aff>
<author-notes><corresp id="CR1"><bold>Corresponding Author:</bold>
Alvaro Urbano-Ispizua, <email>aurbano@clinic.ub.es</email>
. Tel +34 93 454 9543. Fax +34 93 453 1263. Department of Hematology, Hospital Clinic, Villarroel 170, 08036, Barcelona, Spain</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>16</day>
<month>6</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub"><day>15</day>
<month>5</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="ppub"><month>10</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>10</month>
<year>2016</year>
</pub-date>
<volume>21</volume>
<issue>10</issue>
<fpage>1746</fpage>
<lpage>1753</lpage>
<pmc-comment>elocation-id from pubmed: 10.1016/j.bbmt.2015.05.010</pmc-comment>
<abstract><sec id="S1"><title>Purpose</title>
<p id="P1">To analyze the impact of graft versus host disease (GVHD) on the relapse rate of different lymphoma subtypes after allogeneic hematopoietic cell transplantation (allo-HCT).</p>
</sec>
<sec id="S2"><title>Patients and Methods</title>
<p id="P2">Adult patients with a diagnosis of Hodgkin lymphoma (HL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), peripheral T-cell lymphoma (PTCL), or mantle cell lymphoma (MCL) undergoing HLA-identical sibling or unrelated donor HCT between 1997 and 2009 were included.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Two thousand six hundred and eleven cases were included. Reduced-intensity conditioning (RIC) regimen was used in 62.8% of the transplants. In a multivariate analysis of myeloablative cases (n=970), neither acute (aGVHD) nor chronic GVHD (cGVHD) were significantly associated with a lower incidence of relapse/progression in any lymphoma subtype. In contrast, the analysis of RIC cases (n=1641) showed that cGVHD was associated with a lower incidence of relapse/progression in FL (RR 0.51, p=0.049) and in MCL (RR 0.41, p=0.019). Patients with FL or MCL developing both aGVHD and cGVHD had the lowest risk of relapse (RR 0.14, p=0.007; and RR 0.15, p=0.0019, respectively). Of interest, the effect of GVHD on decreasing relapse was similar in patients with sensitive disease and chemoresistant disease. Unfortunately, both aGVHD and cGVHD had a deleterious effect on treatment related mortality (TRM) and overall survival (OS) in FL cases, and did not impact TRM, OS or PFS in MCL.</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">This study reinforces the use of RIC allo-HCT as a platform for immunotherapy in follicular and mantle cell lymphoma patients.</p>
</sec>
</abstract>
</article-meta>
</front>
</pmc>
</record>
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