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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Allotransplantation for patients age 40 years and greater with non-Hodgkin Lymphoma (NHL): encouraging progression-free survival</title><author><name sortKey="Mcclune, Brian L" sort="Mcclune, Brian L" uniqKey="Mcclune B" first="Brian L." last="Mcclune">Brian L. Mcclune</name><affiliation><nlm:aff id="A1">Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN</nlm:aff></affiliation></author><author><name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name><affiliation><nlm:aff id="A2">Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation></author><author><name sortKey="Wang, Hai Lin" sort="Wang, Hai Lin" uniqKey="Wang H" first="Hai-Lin" last="Wang">Hai-Lin Wang</name><affiliation><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation></author><author><name sortKey="Antin, Joseph H" sort="Antin, Joseph H" uniqKey="Antin J" first="Joseph H." last="Antin">Joseph H. Antin</name><affiliation><nlm:aff id="A4">Division of Hematologic Oncology, Dana Farber Cancer Institute, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Artz, Andrew S" sort="Artz, Andrew S" uniqKey="Artz A" first="Andrew S." last="Artz">Andrew S. Artz</name><affiliation><nlm:aff id="A5">University of Chicago School of Medicine, Chicago IL</nlm:aff></affiliation></author><author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name><affiliation><nlm:aff id="A6">Department of Hematology, University Hospital, Grenoble, France</nlm:aff></affiliation></author><author><name sortKey="Deol, Abhinav" sort="Deol, Abhinav" uniqKey="Deol A" first="Abhinav" last="Deol">Abhinav Deol</name><affiliation><nlm:aff id="A7">Karmanos Cancer Institute, Wayne State University, Detroit, MI</nlm:aff></affiliation></author><author><name sortKey="Freytes, Cesar O" sort="Freytes, Cesar O" uniqKey="Freytes C" first="César O." last="Freytes">César O. Freytes</name><affiliation><nlm:aff id="A8">South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio, TX</nlm:aff></affiliation></author><author><name sortKey="Hamadani, Mehdi" sort="Hamadani, Mehdi" uniqKey="Hamadani M" first="Mehdi" last="Hamadani">Mehdi Hamadani</name><affiliation><nlm:aff id="A9">West Virginia University Hospitals, Inc., Morgantown, WV</nlm:aff></affiliation></author><author><name sortKey="Holmberg, Leona A" sort="Holmberg, Leona A" uniqKey="Holmberg L" first="Leona A." last="Holmberg">Leona A. Holmberg</name><affiliation><nlm:aff id="A10">Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff></affiliation></author><author><name sortKey="Jagasia, Madan H" sort="Jagasia, Madan H" uniqKey="Jagasia M" first="Madan H." last="Jagasia">Madan H. Jagasia</name><affiliation><nlm:aff id="A11">Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN</nlm:aff></affiliation></author><author><name sortKey="Jakubowski, Ann A" sort="Jakubowski, Ann A" uniqKey="Jakubowski A" first="Ann A." last="Jakubowski">Ann A. Jakubowski</name><affiliation><nlm:aff id="A12">Memorial Sloan-Kettering Cancer Center, New York, NY</nlm:aff></affiliation></author><author><name sortKey="Kharfan Dabaja, Mohamed A" sort="Kharfan Dabaja, Mohamed A" uniqKey="Kharfan Dabaja M" first="Mohamed A." last="Kharfan-Dabaja">Mohamed A. Kharfan-Dabaja</name><affiliation><nlm:aff id="A13">Department of Blood and Marrow Transplantation, Moffitt Cancer Center, Tampa, FL</nlm:aff></affiliation></author><author><name sortKey="Lazarus, Hillard M" sort="Lazarus, Hillard M" uniqKey="Lazarus H" first="Hillard M." last="Lazarus">Hillard M. Lazarus</name><affiliation><nlm:aff id="A14">Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH</nlm:aff></affiliation></author><author><name sortKey="Miller, Alan M" sort="Miller, Alan M" uniqKey="Miller A" first="Alan M." last="Miller">Alan M. Miller</name><affiliation><nlm:aff id="A15">Baylor University Medical Center, Dallas, TX</nlm:aff></affiliation></author><author><name sortKey="Olsson, Richard" sort="Olsson, Richard" uniqKey="Olsson R" first="Richard" last="Olsson">Richard Olsson</name><affiliation><nlm:aff id="A16">Centre for Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Pedersen, Tanya L" sort="Pedersen, Tanya L" uniqKey="Pedersen T" first="Tanya L." last="Pedersen">Tanya L. Pedersen</name><affiliation><nlm:aff id="A17">Center for International Blood and Marrow Transplant Research, Minneapolis, MN</nlm:aff></affiliation></author><author><name sortKey="Pidala, Joseph" sort="Pidala, Joseph" uniqKey="Pidala J" first="Joseph" last="Pidala">Joseph Pidala</name><affiliation><nlm:aff id="A13">Department of Blood and Marrow Transplantation, Moffitt Cancer Center, Tampa, FL</nlm:aff></affiliation></author><author><name sortKey="Pulsipher, Michael A" sort="Pulsipher, Michael A" uniqKey="Pulsipher M" first="Michael A." last="Pulsipher">Michael A. Pulsipher</name><affiliation><nlm:aff id="A18">Primary Children’s Hospital, Division of Hematology/Hematological Malignancies, Huntsman Cancer Institute/University of Utah, Salt Lake City, UT</nlm:aff></affiliation></author><author><name sortKey="Rowe, Jacob M" sort="Rowe, Jacob M" uniqKey="Rowe J" first="Jacob M." last="Rowe">Jacob M. Rowe</name><affiliation><nlm:aff id="A19">Department of Hematology, Rambam Medical Center, Haifa, Israel</nlm:aff></affiliation></author><author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name><affiliation><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation></author><author><name sortKey="Van Besien, Koen W" sort="Van Besien, Koen W" uniqKey="Van Besien K" first="Koen W." last="Van Besien">Koen W. Van Besien</name><affiliation><nlm:aff id="A20">Weill Cornell Medical College, New York, NY</nlm:aff></affiliation></author><author><name sortKey="Waller, Edmund K" sort="Waller, Edmund K" uniqKey="Waller E" first="Edmund K." last="Waller">Edmund K. Waller</name><affiliation><nlm:aff id="A21">Bone Marrow and Stem Cell Transplant Center, Emory University Hospital, Atlanta, GA</nlm:aff></affiliation></author><author><name sortKey="Aljurf, Mahmoud D" sort="Aljurf, Mahmoud D" uniqKey="Aljurf M" first="Mahmoud D." last="Aljurf">Mahmoud D. Aljurf</name><affiliation><nlm:aff id="A22">Department of Oncology, King Faisal Specialist Hospital Center and Research, Riyadh, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Akpek, Gorgun" sort="Akpek, Gorgun" uniqKey="Akpek G" first="Görgun" last="Akpek">Görgun Akpek</name><affiliation><nlm:aff id="A23">Banner MD Anderson Cancer Center, Gilbert, AZ</nlm:aff></affiliation></author><author><name sortKey="Bacher, Ulrike" sort="Bacher, Ulrike" uniqKey="Bacher U" first="Ulrike" last="Bacher">Ulrike Bacher</name><affiliation><nlm:aff id="A24">Universitatsklinikum Hamburg, Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Chao, Nelson J" sort="Chao, Nelson J" uniqKey="Chao N" first="Nelson J." last="Chao">Nelson J. Chao</name><affiliation><nlm:aff id="A25">Division of Cell Therapy, Duke University Medical Center, Durham, NC</nlm:aff></affiliation></author><author><name sortKey="Chen, Yi Bin" sort="Chen, Yi Bin" uniqKey="Chen Y" first="Yi-Bin" last="Chen">Yi-Bin Chen</name><affiliation><nlm:aff id="A26">Division of Hematology/Oncology, Massachusetts General Hospital, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Cooper, Brenda W" sort="Cooper, Brenda W" uniqKey="Cooper B" first="Brenda W." last="Cooper">Brenda W. Cooper</name><affiliation><nlm:aff id="A27">Division of Hematology/Oncology, University Hospitals Case Medical Center, Cleveland, OH</nlm:aff></affiliation></author><author><name sortKey="Dehn, Jason" sort="Dehn, Jason" uniqKey="Dehn J" first="Jason" last="Dehn">Jason Dehn</name><affiliation><nlm:aff id="A28">National Marrow Donor Program, Minneapolis, MN</nlm:aff></affiliation></author><author><name sortKey="De Lima, Marcos J" sort="De Lima, Marcos J" uniqKey="De Lima M" first="Marcos J." last="De Lima">Marcos J. De Lima</name><affiliation><nlm:aff id="A27">Division of Hematology/Oncology, University Hospitals Case Medical Center, Cleveland, OH</nlm:aff></affiliation></author><author><name sortKey="Hsu, Jack W" sort="Hsu, Jack W" uniqKey="Hsu J" first="Jack W." last="Hsu">Jack W. Hsu</name><affiliation><nlm:aff id="A29">Division of Hematology/Oncology, Shands HealthCare, University of Florida, Gainesville, FL</nlm:aff></affiliation></author><author><name sortKey="Lewis, Ian D" sort="Lewis, Ian D" uniqKey="Lewis I" first="Ian D." last="Lewis">Ian D. Lewis</name><affiliation><nlm:aff id="A30">Haematology Clinical Trial Office, Royal Adelaide Hospital/SA Pathology, Adelaide, Australia</nlm:aff></affiliation></author><author><name sortKey="Marks, David I" sort="Marks, David I" uniqKey="Marks D" first="David I." last="Marks">David I. Marks</name><affiliation><nlm:aff id="A31">Avon Haematology Unit and BCH BMT Unit, Bristol Children’s Hospital, Bristol, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Mcguirk, Joseph" sort="Mcguirk, Joseph" uniqKey="Mcguirk J" first="Joseph" last="Mcguirk">Joseph Mcguirk</name><affiliation><nlm:aff id="A32">Division of Hematology & Oncology, University of Kansas, Westwood, KS</nlm:aff></affiliation></author><author><name sortKey="Cairo, Mitchell S" sort="Cairo, Mitchell S" uniqKey="Cairo M" first="Mitchell S." last="Cairo">Mitchell S. Cairo</name><affiliation><nlm:aff id="A33">Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, New York Medical College, Valhalla, NY</nlm:aff></affiliation></author><author><name sortKey="Schouten, Harry C" sort="Schouten, Harry C" uniqKey="Schouten H" first="Harry C." last="Schouten">Harry C. Schouten</name><affiliation><nlm:aff id="A34">Division of Hematology, Academische Ziekenhuis Maastricht, Maastricht, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Szer, Jeffrey" sort="Szer, Jeffrey" uniqKey="Szer J" first="Jeffrey" last="Szer">Jeffrey Szer</name><affiliation><nlm:aff id="A35">Department of Clinical Haematology and Bone Marrow Transplantation, Royal Melbourne Hospital City Campus, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Ramanathan, Muthalagu" sort="Ramanathan, Muthalagu" uniqKey="Ramanathan M" first="Muthalagu" last="Ramanathan">Muthalagu Ramanathan</name><affiliation><nlm:aff id="A36">Department of Hematologic Malignancies Bone Marrow Transplant, UMass Memorial Medical Center, Worcester, MA</nlm:aff></affiliation></author><author><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N." last="Savani">Bipin N. Savani</name><affiliation><nlm:aff id="A11">Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN</nlm:aff></affiliation></author><author><name sortKey="Seftel, Matthew" sort="Seftel, Matthew" uniqKey="Seftel M" first="Matthew" last="Seftel">Matthew Seftel</name><affiliation><nlm:aff id="A37">Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Socie, Gerard" sort="Socie, Gerard" uniqKey="Socie G" first="Gérard" last="Socie">Gérard Socie</name><affiliation><nlm:aff id="A38">Department of Hematology, Hopital Saint Louis, Paris</nlm:aff></affiliation></author><author><name sortKey="Vij, Ravi" sort="Vij, Ravi" uniqKey="Vij R" first="Ravi" last="Vij">Ravi Vij</name><affiliation><nlm:aff id="A39">Division of Medical Oncology, Barnes Jewish Hospital, St. Louis Children’s Hospital, Washington University, St. Louis, MO</nlm:aff></affiliation></author><author><name sortKey="Warlick, Erica D" sort="Warlick, Erica D" uniqKey="Warlick E" first="Erica D." last="Warlick">Erica D. Warlick</name><affiliation><nlm:aff id="A1">Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN</nlm:aff></affiliation></author><author><name sortKey="Weisdorf, Daniel J" sort="Weisdorf, Daniel J" uniqKey="Weisdorf D" first="Daniel J." last="Weisdorf">Daniel J. Weisdorf</name><affiliation><nlm:aff id="A1">Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24641829</idno><idno type="pmc">4057955</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057955</idno><idno type="RBID">PMC:4057955</idno><idno type="doi">10.1016/j.bbmt.2014.03.013</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002188</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002188</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Allotransplantation for patients age 40 years and greater with non-Hodgkin Lymphoma (NHL): encouraging progression-free survival</title><author><name sortKey="Mcclune, Brian L" sort="Mcclune, Brian L" uniqKey="Mcclune B" first="Brian L." last="Mcclune">Brian L. Mcclune</name><affiliation><nlm:aff id="A1">Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN</nlm:aff></affiliation></author><author><name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name><affiliation><nlm:aff id="A2">Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation></author><author><name sortKey="Wang, Hai Lin" sort="Wang, Hai Lin" uniqKey="Wang H" first="Hai-Lin" last="Wang">Hai-Lin Wang</name><affiliation><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation></author><author><name sortKey="Antin, Joseph H" sort="Antin, Joseph H" uniqKey="Antin J" first="Joseph H." last="Antin">Joseph H. Antin</name><affiliation><nlm:aff id="A4">Division of Hematologic Oncology, Dana Farber Cancer Institute, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Artz, Andrew S" sort="Artz, Andrew S" uniqKey="Artz A" first="Andrew S." last="Artz">Andrew S. Artz</name><affiliation><nlm:aff id="A5">University of Chicago School of Medicine, Chicago IL</nlm:aff></affiliation></author><author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name><affiliation><nlm:aff id="A6">Department of Hematology, University Hospital, Grenoble, France</nlm:aff></affiliation></author><author><name sortKey="Deol, Abhinav" sort="Deol, Abhinav" uniqKey="Deol A" first="Abhinav" last="Deol">Abhinav Deol</name><affiliation><nlm:aff id="A7">Karmanos Cancer Institute, Wayne State University, Detroit, MI</nlm:aff></affiliation></author><author><name sortKey="Freytes, Cesar O" sort="Freytes, Cesar O" uniqKey="Freytes C" first="César O." last="Freytes">César O. Freytes</name><affiliation><nlm:aff id="A8">South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio, TX</nlm:aff></affiliation></author><author><name sortKey="Hamadani, Mehdi" sort="Hamadani, Mehdi" uniqKey="Hamadani M" first="Mehdi" last="Hamadani">Mehdi Hamadani</name><affiliation><nlm:aff id="A9">West Virginia University Hospitals, Inc., Morgantown, WV</nlm:aff></affiliation></author><author><name sortKey="Holmberg, Leona A" sort="Holmberg, Leona A" uniqKey="Holmberg L" first="Leona A." last="Holmberg">Leona A. Holmberg</name><affiliation><nlm:aff id="A10">Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff></affiliation></author><author><name sortKey="Jagasia, Madan H" sort="Jagasia, Madan H" uniqKey="Jagasia M" first="Madan H." last="Jagasia">Madan H. Jagasia</name><affiliation><nlm:aff id="A11">Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN</nlm:aff></affiliation></author><author><name sortKey="Jakubowski, Ann A" sort="Jakubowski, Ann A" uniqKey="Jakubowski A" first="Ann A." last="Jakubowski">Ann A. Jakubowski</name><affiliation><nlm:aff id="A12">Memorial Sloan-Kettering Cancer Center, New York, NY</nlm:aff></affiliation></author><author><name sortKey="Kharfan Dabaja, Mohamed A" sort="Kharfan Dabaja, Mohamed A" uniqKey="Kharfan Dabaja M" first="Mohamed A." last="Kharfan-Dabaja">Mohamed A. Kharfan-Dabaja</name><affiliation><nlm:aff id="A13">Department of Blood and Marrow Transplantation, Moffitt Cancer Center, Tampa, FL</nlm:aff></affiliation></author><author><name sortKey="Lazarus, Hillard M" sort="Lazarus, Hillard M" uniqKey="Lazarus H" first="Hillard M." last="Lazarus">Hillard M. Lazarus</name><affiliation><nlm:aff id="A14">Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH</nlm:aff></affiliation></author><author><name sortKey="Miller, Alan M" sort="Miller, Alan M" uniqKey="Miller A" first="Alan M." last="Miller">Alan M. Miller</name><affiliation><nlm:aff id="A15">Baylor University Medical Center, Dallas, TX</nlm:aff></affiliation></author><author><name sortKey="Olsson, Richard" sort="Olsson, Richard" uniqKey="Olsson R" first="Richard" last="Olsson">Richard Olsson</name><affiliation><nlm:aff id="A16">Centre for Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Pedersen, Tanya L" sort="Pedersen, Tanya L" uniqKey="Pedersen T" first="Tanya L." last="Pedersen">Tanya L. Pedersen</name><affiliation><nlm:aff id="A17">Center for International Blood and Marrow Transplant Research, Minneapolis, MN</nlm:aff></affiliation></author><author><name sortKey="Pidala, Joseph" sort="Pidala, Joseph" uniqKey="Pidala J" first="Joseph" last="Pidala">Joseph Pidala</name><affiliation><nlm:aff id="A13">Department of Blood and Marrow Transplantation, Moffitt Cancer Center, Tampa, FL</nlm:aff></affiliation></author><author><name sortKey="Pulsipher, Michael A" sort="Pulsipher, Michael A" uniqKey="Pulsipher M" first="Michael A." last="Pulsipher">Michael A. Pulsipher</name><affiliation><nlm:aff id="A18">Primary Children’s Hospital, Division of Hematology/Hematological Malignancies, Huntsman Cancer Institute/University of Utah, Salt Lake City, UT</nlm:aff></affiliation></author><author><name sortKey="Rowe, Jacob M" sort="Rowe, Jacob M" uniqKey="Rowe J" first="Jacob M." last="Rowe">Jacob M. Rowe</name><affiliation><nlm:aff id="A19">Department of Hematology, Rambam Medical Center, Haifa, Israel</nlm:aff></affiliation></author><author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name><affiliation><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation></author><author><name sortKey="Van Besien, Koen W" sort="Van Besien, Koen W" uniqKey="Van Besien K" first="Koen W." last="Van Besien">Koen W. Van Besien</name><affiliation><nlm:aff id="A20">Weill Cornell Medical College, New York, NY</nlm:aff></affiliation></author><author><name sortKey="Waller, Edmund K" sort="Waller, Edmund K" uniqKey="Waller E" first="Edmund K." last="Waller">Edmund K. Waller</name><affiliation><nlm:aff id="A21">Bone Marrow and Stem Cell Transplant Center, Emory University Hospital, Atlanta, GA</nlm:aff></affiliation></author><author><name sortKey="Aljurf, Mahmoud D" sort="Aljurf, Mahmoud D" uniqKey="Aljurf M" first="Mahmoud D." last="Aljurf">Mahmoud D. Aljurf</name><affiliation><nlm:aff id="A22">Department of Oncology, King Faisal Specialist Hospital Center and Research, Riyadh, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Akpek, Gorgun" sort="Akpek, Gorgun" uniqKey="Akpek G" first="Görgun" last="Akpek">Görgun Akpek</name><affiliation><nlm:aff id="A23">Banner MD Anderson Cancer Center, Gilbert, AZ</nlm:aff></affiliation></author><author><name sortKey="Bacher, Ulrike" sort="Bacher, Ulrike" uniqKey="Bacher U" first="Ulrike" last="Bacher">Ulrike Bacher</name><affiliation><nlm:aff id="A24">Universitatsklinikum Hamburg, Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Chao, Nelson J" sort="Chao, Nelson J" uniqKey="Chao N" first="Nelson J." last="Chao">Nelson J. Chao</name><affiliation><nlm:aff id="A25">Division of Cell Therapy, Duke University Medical Center, Durham, NC</nlm:aff></affiliation></author><author><name sortKey="Chen, Yi Bin" sort="Chen, Yi Bin" uniqKey="Chen Y" first="Yi-Bin" last="Chen">Yi-Bin Chen</name><affiliation><nlm:aff id="A26">Division of Hematology/Oncology, Massachusetts General Hospital, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Cooper, Brenda W" sort="Cooper, Brenda W" uniqKey="Cooper B" first="Brenda W." last="Cooper">Brenda W. Cooper</name><affiliation><nlm:aff id="A27">Division of Hematology/Oncology, University Hospitals Case Medical Center, Cleveland, OH</nlm:aff></affiliation></author><author><name sortKey="Dehn, Jason" sort="Dehn, Jason" uniqKey="Dehn J" first="Jason" last="Dehn">Jason Dehn</name><affiliation><nlm:aff id="A28">National Marrow Donor Program, Minneapolis, MN</nlm:aff></affiliation></author><author><name sortKey="De Lima, Marcos J" sort="De Lima, Marcos J" uniqKey="De Lima M" first="Marcos J." last="De Lima">Marcos J. De Lima</name><affiliation><nlm:aff id="A27">Division of Hematology/Oncology, University Hospitals Case Medical Center, Cleveland, OH</nlm:aff></affiliation></author><author><name sortKey="Hsu, Jack W" sort="Hsu, Jack W" uniqKey="Hsu J" first="Jack W." last="Hsu">Jack W. Hsu</name><affiliation><nlm:aff id="A29">Division of Hematology/Oncology, Shands HealthCare, University of Florida, Gainesville, FL</nlm:aff></affiliation></author><author><name sortKey="Lewis, Ian D" sort="Lewis, Ian D" uniqKey="Lewis I" first="Ian D." last="Lewis">Ian D. Lewis</name><affiliation><nlm:aff id="A30">Haematology Clinical Trial Office, Royal Adelaide Hospital/SA Pathology, Adelaide, Australia</nlm:aff></affiliation></author><author><name sortKey="Marks, David I" sort="Marks, David I" uniqKey="Marks D" first="David I." last="Marks">David I. Marks</name><affiliation><nlm:aff id="A31">Avon Haematology Unit and BCH BMT Unit, Bristol Children’s Hospital, Bristol, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Mcguirk, Joseph" sort="Mcguirk, Joseph" uniqKey="Mcguirk J" first="Joseph" last="Mcguirk">Joseph Mcguirk</name><affiliation><nlm:aff id="A32">Division of Hematology & Oncology, University of Kansas, Westwood, KS</nlm:aff></affiliation></author><author><name sortKey="Cairo, Mitchell S" sort="Cairo, Mitchell S" uniqKey="Cairo M" first="Mitchell S." last="Cairo">Mitchell S. Cairo</name><affiliation><nlm:aff id="A33">Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, New York Medical College, Valhalla, NY</nlm:aff></affiliation></author><author><name sortKey="Schouten, Harry C" sort="Schouten, Harry C" uniqKey="Schouten H" first="Harry C." last="Schouten">Harry C. Schouten</name><affiliation><nlm:aff id="A34">Division of Hematology, Academische Ziekenhuis Maastricht, Maastricht, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Szer, Jeffrey" sort="Szer, Jeffrey" uniqKey="Szer J" first="Jeffrey" last="Szer">Jeffrey Szer</name><affiliation><nlm:aff id="A35">Department of Clinical Haematology and Bone Marrow Transplantation, Royal Melbourne Hospital City Campus, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Ramanathan, Muthalagu" sort="Ramanathan, Muthalagu" uniqKey="Ramanathan M" first="Muthalagu" last="Ramanathan">Muthalagu Ramanathan</name><affiliation><nlm:aff id="A36">Department of Hematologic Malignancies Bone Marrow Transplant, UMass Memorial Medical Center, Worcester, MA</nlm:aff></affiliation></author><author><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N." last="Savani">Bipin N. Savani</name><affiliation><nlm:aff id="A11">Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN</nlm:aff></affiliation></author><author><name sortKey="Seftel, Matthew" sort="Seftel, Matthew" uniqKey="Seftel M" first="Matthew" last="Seftel">Matthew Seftel</name><affiliation><nlm:aff id="A37">Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Socie, Gerard" sort="Socie, Gerard" uniqKey="Socie G" first="Gérard" last="Socie">Gérard Socie</name><affiliation><nlm:aff id="A38">Department of Hematology, Hopital Saint Louis, Paris</nlm:aff></affiliation></author><author><name sortKey="Vij, Ravi" sort="Vij, Ravi" uniqKey="Vij R" first="Ravi" last="Vij">Ravi Vij</name><affiliation><nlm:aff id="A39">Division of Medical Oncology, Barnes Jewish Hospital, St. Louis Children’s Hospital, Washington University, St. Louis, MO</nlm:aff></affiliation></author><author><name sortKey="Warlick, Erica D" sort="Warlick, Erica D" uniqKey="Warlick E" first="Erica D." last="Warlick">Erica D. Warlick</name><affiliation><nlm:aff id="A1">Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN</nlm:aff></affiliation></author><author><name sortKey="Weisdorf, Daniel J" sort="Weisdorf, Daniel J" uniqKey="Weisdorf D" first="Daniel J." last="Weisdorf">Daniel J. Weisdorf</name><affiliation><nlm:aff id="A1">Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN</nlm:aff></affiliation></author></analytic><series><title level="j">Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</title><idno type="ISSN">1083-8791</idno><idno type="eISSN">1523-6536</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Non-Hodgkin lymphomas (NHL) disproportionately affect older patients who uncommonly receive allogeneic hematopoietic cell transplantation (HCT). We analyzed CIBMTR data on 1248 patients ≥40 years receiving reduced-intensity conditioning (RIC) or non-myeloablative (NMA) HCT for aggressive (n=668) and indolent (n=580) NHL. Aggressive lymphoma was more frequent in the oldest cohort [(age 40–54) 49% vs. (55–64) 57% vs. (≥65) 67% p=0.0008]; fewer patients ≥65 had prior autografting [26% vs. 24% vs. 9%; p=0.002)]. Rates of relapse, acute and chronic GVHD and non-relapse mortality (NRM) at one year were similar [22%, 95% confidence interval (CI) 19–26%; 27%, 95% CI 23–31%; 34%, 95% CI 24–44%]. Progression-free (PFS) and overall (OS) survival at 3 years was slightly lower in older cohorts [OS:54%, 95% CI 50–58%; 40%, 95% CI 36–44%; 39%, 95% CI 28–50%; p<0.0001]. Multivariate analysis revealed no significant effect of age on acute or chronic GVHD or relapse. Age ≥55 years, Karnofsky performance status <80, and HLA-mismatch adversely impacted NRM, PFS, and OS. Disease status at HCT, but not histologic subtype, worsened NRM, relapse, PFS and OS. Even for patients ≥55 years, OS still approached 40% at 3 years suggesting HCT effects long-term remissions and remains underutilized in qualified older patients with NHL.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9600628</journal-id><journal-id journal-id-type="pubmed-jr-id">20830</journal-id><journal-id journal-id-type="nlm-ta">Biol Blood Marrow Transplant</journal-id><journal-id journal-id-type="iso-abbrev">Biol. Blood Marrow Transplant.</journal-id><journal-title-group><journal-title>Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</journal-title></journal-title-group><issn pub-type="ppub">1083-8791</issn><issn pub-type="epub">1523-6536</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24641829</article-id><article-id pub-id-type="pmc">4057955</article-id><article-id pub-id-type="doi">10.1016/j.bbmt.2014.03.013</article-id><article-id pub-id-type="manuscript">NIHMS577269</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Allotransplantation for patients age 40 years and greater with non-Hodgkin Lymphoma (NHL): encouraging progression-free survival</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>McClune</surname><given-names>Brian L.</given-names></name><degrees>DO</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Ahn</surname><given-names>Kwang Woo</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Hai-Lin</given-names></name><degrees>MPH</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Antin</surname><given-names>Joseph H.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Artz</surname><given-names>Andrew S.</given-names></name><degrees>MD, MS</degrees><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Cahn</surname><given-names>Jean-Yves</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Deol</surname><given-names>Abhinav</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Freytes</surname><given-names>César O.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Hamadani</surname><given-names>Mehdi</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Holmberg</surname><given-names>Leona A.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Jagasia</surname><given-names>Madan H.</given-names></name><degrees>MBBS, MS</degrees><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Jakubowski</surname><given-names>Ann A.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Kharfan-Dabaja</surname><given-names>Mohamed A.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Lazarus</surname><given-names>Hillard M.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Miller</surname><given-names>Alan M.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Olsson</surname><given-names>Richard</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Pedersen</surname><given-names>Tanya L.</given-names></name><degrees>MPH</degrees><xref ref-type="aff" rid="A17">17</xref></contrib><contrib contrib-type="author"><name><surname>Pidala</surname><given-names>Joseph</given-names></name><degrees>MD, MS</degrees><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Pulsipher</surname><given-names>Michael A.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Rowe</surname><given-names>Jacob M.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Saber</surname><given-names>Wael</given-names></name><degrees>MD, MS</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>van Besien</surname><given-names>Koen W.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Waller</surname><given-names>Edmund K.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Aljurf</surname><given-names>Mahmoud D.</given-names></name><degrees>MD, MPH</degrees><xref ref-type="aff" rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>Akpek</surname><given-names>Görgun</given-names></name><degrees>MD, MHS</degrees><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Bacher</surname><given-names>Ulrike</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A24">24</xref></contrib><contrib contrib-type="author"><name><surname>Chao</surname><given-names>Nelson J.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A25">25</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Yi-Bin</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A26">26</xref></contrib><contrib contrib-type="author"><name><surname>Cooper</surname><given-names>Brenda W.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A27">27</xref></contrib><contrib contrib-type="author"><name><surname>Dehn</surname><given-names>Jason</given-names></name><degrees>MPH; CHTC</degrees><xref ref-type="aff" rid="A28">28</xref></contrib><contrib contrib-type="author"><name><surname>de Lima</surname><given-names>Marcos J.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A27">27</xref></contrib><contrib contrib-type="author"><name><surname>Hsu</surname><given-names>Jack W.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A29">29</xref></contrib><contrib contrib-type="author"><name><surname>Lewis</surname><given-names>Ian D.</given-names></name><degrees>MBBS, PhD</degrees><xref ref-type="aff" rid="A30">30</xref></contrib><contrib contrib-type="author"><name><surname>Marks</surname><given-names>David I.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A31">31</xref></contrib><contrib contrib-type="author"><name><surname>McGuirk</surname><given-names>Joseph</given-names></name><degrees>DO</degrees><xref ref-type="aff" rid="A32">32</xref></contrib><contrib contrib-type="author"><name><surname>Cairo</surname><given-names>Mitchell S.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A33">33</xref></contrib><contrib contrib-type="author"><name><surname>Schouten</surname><given-names>Harry C.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A34">34</xref></contrib><contrib contrib-type="author"><name><surname>Szer</surname><given-names>Jeffrey</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A35">35</xref></contrib><contrib contrib-type="author"><name><surname>Ramanathan</surname><given-names>Muthalagu</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A36">36</xref></contrib><contrib contrib-type="author"><name><surname>Savani</surname><given-names>Bipin N.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Seftel</surname><given-names>Matthew</given-names></name><degrees>MBChB, MPH, MRCP, FRCPC</degrees><xref ref-type="aff" rid="A37">37</xref></contrib><contrib contrib-type="author"><name><surname>Socie</surname><given-names>Gérard</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A38">38</xref></contrib><contrib contrib-type="author"><name><surname>Vij</surname><given-names>Ravi</given-names></name><degrees>MBBS</degrees><xref ref-type="aff" rid="A39">39</xref></contrib><contrib contrib-type="author"><name><surname>Warlick</surname><given-names>Erica D.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Weisdorf</surname><given-names>Daniel J.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label>Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN</aff><aff id="A2"><label>2</label>Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI</aff><aff id="A3"><label>3</label>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</aff><aff id="A4"><label>4</label>Division of Hematologic Oncology, Dana Farber Cancer Institute, Boston, MA</aff><aff id="A5"><label>5</label>University of Chicago School of Medicine, Chicago IL</aff><aff id="A6"><label>6</label>Department of Hematology, University Hospital, Grenoble, France</aff><aff id="A7"><label>7</label>Karmanos Cancer Institute, Wayne State University, Detroit, MI</aff><aff id="A8"><label>8</label>South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio, TX</aff><aff id="A9"><label>9</label>West Virginia University Hospitals, Inc., Morgantown, WV</aff><aff id="A10"><label>10</label>Fred Hutchinson Cancer Research Center, Seattle, WA</aff><aff id="A11"><label>11</label>Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN</aff><aff id="A12"><label>12</label>Memorial Sloan-Kettering Cancer Center, New York, NY</aff><aff id="A13"><label>13</label>Department of Blood and Marrow Transplantation, Moffitt Cancer Center, Tampa, FL</aff><aff id="A14"><label>14</label>Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH</aff><aff id="A15"><label>15</label>Baylor University Medical Center, Dallas, TX</aff><aff id="A16"><label>16</label>Centre for Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Stockholm, Sweden</aff><aff id="A17"><label>17</label>Center for International Blood and Marrow Transplant Research, Minneapolis, MN</aff><aff id="A18"><label>18</label>Primary Children’s Hospital, Division of Hematology/Hematological Malignancies, Huntsman Cancer Institute/University of Utah, Salt Lake City, UT</aff><aff id="A19"><label>19</label>Department of Hematology, Rambam Medical Center, Haifa, Israel</aff><aff id="A20"><label>20</label>Weill Cornell Medical College, New York, NY</aff><aff id="A21"><label>21</label>Bone Marrow and Stem Cell Transplant Center, Emory University Hospital, Atlanta, GA</aff><aff id="A22"><label>22</label>Department of Oncology, King Faisal Specialist Hospital Center and Research, Riyadh, Saudi Arabia</aff><aff id="A23"><label>23</label>Banner MD Anderson Cancer Center, Gilbert, AZ</aff><aff id="A24"><label>24</label>Universitatsklinikum Hamburg, Hamburg, Germany</aff><aff id="A25"><label>25</label>Division of Cell Therapy, Duke University Medical Center, Durham, NC</aff><aff id="A26"><label>26</label>Division of Hematology/Oncology, Massachusetts General Hospital, Boston, MA</aff><aff id="A27"><label>27</label>Division of Hematology/Oncology, University Hospitals Case Medical Center, Cleveland, OH</aff><aff id="A28"><label>28</label>National Marrow Donor Program, Minneapolis, MN</aff><aff id="A29"><label>29</label>Division of Hematology/Oncology, Shands HealthCare, University of Florida, Gainesville, FL</aff><aff id="A30"><label>30</label>Haematology Clinical Trial Office, Royal Adelaide Hospital/SA Pathology, Adelaide, Australia</aff><aff id="A31"><label>31</label>Avon Haematology Unit and BCH BMT Unit, Bristol Children’s Hospital, Bristol, United Kingdom</aff><aff id="A32"><label>32</label>Division of Hematology & Oncology, University of Kansas, Westwood, KS</aff><aff id="A33"><label>33</label>Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, New York Medical College, Valhalla, NY</aff><aff id="A34"><label>34</label>Division of Hematology, Academische Ziekenhuis Maastricht, Maastricht, Netherlands</aff><aff id="A35"><label>35</label>Department of Clinical Haematology and Bone Marrow Transplantation, Royal Melbourne Hospital City Campus, Victoria, Australia</aff><aff id="A36"><label>36</label>Department of Hematologic Malignancies Bone Marrow Transplant, UMass Memorial Medical Center, Worcester, MA</aff><aff id="A37"><label>37</label>Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada</aff><aff id="A38"><label>38</label>Department of Hematology, Hopital Saint Louis, Paris</aff><aff id="A39"><label>39</label>Division of Medical Oncology, Barnes Jewish Hospital, St. Louis Children’s Hospital, Washington University, St. Louis, MO</aff><author-notes><corresp id="cor1"><bold>Corresponding author:</bold> Daniel J. Weisdorf, MD; Division of Hematology, Oncology and Transplantation, University of Minnesota, MMC 480, 420 Delaware St. SE, Minneapolis, MN 55455; Telephone: 612-624-3101; Fax: 612-625-6919; <email>weisd001@umn.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>2</day><month>5</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>15</day><month>3</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>7</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>7</month><year>2015</year></pub-date><volume>20</volume><issue>7</issue><fpage>960</fpage><lpage>968</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.bbmt.2014.03.013</pmc-comment>
<permissions><copyright-statement>© 2014 The American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.</copyright-statement><copyright-year>2014</copyright-year></permissions><abstract><p id="P1">Non-Hodgkin lymphomas (NHL) disproportionately affect older patients who uncommonly receive allogeneic hematopoietic cell transplantation (HCT). We analyzed CIBMTR data on 1248 patients ≥40 years receiving reduced-intensity conditioning (RIC) or non-myeloablative (NMA) HCT for aggressive (n=668) and indolent (n=580) NHL. Aggressive lymphoma was more frequent in the oldest cohort [(age 40–54) 49% vs. (55–64) 57% vs. (≥65) 67% p=0.0008]; fewer patients ≥65 had prior autografting [26% vs. 24% vs. 9%; p=0.002)]. Rates of relapse, acute and chronic GVHD and non-relapse mortality (NRM) at one year were similar [22%, 95% confidence interval (CI) 19–26%; 27%, 95% CI 23–31%; 34%, 95% CI 24–44%]. Progression-free (PFS) and overall (OS) survival at 3 years was slightly lower in older cohorts [OS:54%, 95% CI 50–58%; 40%, 95% CI 36–44%; 39%, 95% CI 28–50%; p<0.0001]. Multivariate analysis revealed no significant effect of age on acute or chronic GVHD or relapse. Age ≥55 years, Karnofsky performance status <80, and HLA-mismatch adversely impacted NRM, PFS, and OS. Disease status at HCT, but not histologic subtype, worsened NRM, relapse, PFS and OS. Even for patients ≥55 years, OS still approached 40% at 3 years suggesting HCT effects long-term remissions and remains underutilized in qualified older patients with NHL.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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