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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Increasing Incidence of Chronic Graft-versus-Host Disease in Allogeneic Transplantation – A Report from CIBMTR</title><author><name sortKey="Arai, Sally" sort="Arai, Sally" uniqKey="Arai S" first="Sally" last="Arai">Sally Arai</name><affiliation><nlm:aff id="A1">Division of Bone Marrow Transplant, Stanford University Medical Center, Stanford, CA</nlm:aff></affiliation></author><author><name sortKey="Arora, Mukta" sort="Arora, Mukta" uniqKey="Arora M" first="Mukta" last="Arora">Mukta Arora</name><affiliation><nlm:aff id="A2">Division of Hematology, Oncology and Transplant, University of Minnesota Medical Center, Minneapolis, MN</nlm:aff></affiliation></author><author><name sortKey="Wang, Tao" sort="Wang, Tao" uniqKey="Wang T" first="Tao" last="Wang">Tao Wang</name><affiliation><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation></author><author><name sortKey="Spellman, Stephen R" sort="Spellman, Stephen R" uniqKey="Spellman S" first="Stephen R." last="Spellman">Stephen R. Spellman</name><affiliation><nlm:aff id="A5">Center for International Blood and Marrow Transplant Research, National Marrow Donor Program, Minneapolis, MN</nlm:aff></affiliation></author><author><name sortKey="He, Wensheng" sort="He, Wensheng" uniqKey="He W" first="Wensheng" last="He">Wensheng He</name><affiliation><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation></author><author><name sortKey="Couriel, Daniel R" sort="Couriel, Daniel R" uniqKey="Couriel D" first="Daniel R." last="Couriel">Daniel R. Couriel</name><affiliation><nlm:aff id="A6">Division of Hematology/Oncology, The University of Michigan, Ann Arbor, MI</nlm:aff></affiliation></author><author><name sortKey="Urbano Ispizua, Alvaro" sort="Urbano Ispizua, Alvaro" uniqKey="Urbano Ispizua A" first="Alvaro" last="Urbano-Ispizua">Alvaro Urbano-Ispizua</name><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital Clinic of Barcelona, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Cutler, Corey S" sort="Cutler, Corey S" uniqKey="Cutler C" first="Corey S." last="Cutler">Corey S. Cutler</name><affiliation><nlm:aff id="A8">Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Bacigalupo, Andrea A" sort="Bacigalupo, Andrea A" uniqKey="Bacigalupo A" first="Andrea A." last="Bacigalupo">Andrea A. Bacigalupo</name><affiliation><nlm:aff id="A9">Department of Hematology, IRCCS AOU San Martino-IST, Genoa, Italy</nlm:aff></affiliation></author><author><name sortKey="Battiwalla, Minoo" sort="Battiwalla, Minoo" uniqKey="Battiwalla M" first="Minoo" last="Battiwalla">Minoo Battiwalla</name><affiliation><nlm:aff id="A10">Branch of Hematology, National Heart Lung and Blood Institute, Bethesda, MD</nlm:aff></affiliation></author><author><name sortKey="Flowers, Mary E" sort="Flowers, Mary E" uniqKey="Flowers M" first="Mary E." last="Flowers">Mary E. Flowers</name><affiliation><nlm:aff id="A11">Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA</nlm:aff></affiliation></author><author><name sortKey="Juckett, Mark B" sort="Juckett, Mark B" uniqKey="Juckett M" first="Mark B." last="Juckett">Mark B. Juckett</name><affiliation><nlm:aff id="A12">Division of Hematology/Oncology/Bone Marrow Transplantation, Department of Medicine, University of Wisconsin Hospital and Clinics, Madison, WI</nlm:aff></affiliation></author><author><name sortKey="Lee, Stephanie J" sort="Lee, Stephanie J" uniqKey="Lee S" first="Stephanie J." last="Lee">Stephanie J. Lee</name><affiliation><nlm:aff id="A13">Divison of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff></affiliation></author><author><name sortKey="Loren, Alison W" sort="Loren, Alison W" uniqKey="Loren A" first="Alison W." last="Loren">Alison W. Loren</name><affiliation><nlm:aff id="A14">Division of Hematology/Oncology, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA</nlm:aff></affiliation></author><author><name sortKey="Klumpp, Thomas R" sort="Klumpp, Thomas R" uniqKey="Klumpp T" first="Thomas R." last="Klumpp">Thomas R. Klumpp</name><affiliation><nlm:aff id="A15">Divison of Bone Marrow Transplantation, Temple Bone Marrow Transplant Program, Philadelphia, PA</nlm:aff></affiliation></author><author><name sortKey="Prockup, Susan E" sort="Prockup, Susan E" uniqKey="Prockup S" first="Susan E." last="Prockup">Susan E. Prockup</name><affiliation><nlm:aff id="A16">Divison of Bone Marrow Transplant, Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY</nlm:aff></affiliation></author><author><name sortKey="Ringden, Olle T H" sort="Ringden, Olle T H" uniqKey="Ringden O" first="Olle T. H." last="Ringdén">Olle T. H. Ringdén</name><affiliation><nlm:aff id="A17">Division of Clinical Immunology and Center for Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N." last="Savani">Bipin N. Savani</name><affiliation><nlm:aff id="A18">Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN</nlm:aff></affiliation></author><author><name sortKey="Socie, Gerard" sort="Socie, Gerard" uniqKey="Socie G" first="Gérard" last="Socié">Gérard Socié</name><affiliation><nlm:aff id="A19">Division of Hematology, Hopital Saint Louis, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Schultz, Kirk R" sort="Schultz, Kirk R" uniqKey="Schultz K" first="Kirk R." last="Schultz">Kirk R. Schultz</name><affiliation><nlm:aff id="A20">Department of Pediatric Hematology/Oncology/BMT, British Columbia’s Children’s Hospital, University of British Columbia, Vancouver, British Columbia, Canada</nlm:aff></affiliation></author><author><name sortKey="Spitzer, Thomas" sort="Spitzer, Thomas" uniqKey="Spitzer T" first="Thomas" last="Spitzer">Thomas Spitzer</name><affiliation><nlm:aff id="A21">Department of Bone Marrow Transplant-Oncology, Massachusetts General Hospital, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Teshima, Takanori" sort="Teshima, Takanori" uniqKey="Teshima T" first="Takanori" last="Teshima">Takanori Teshima</name><affiliation><nlm:aff id="A22">Kyushu University Hospital, Fukuoka, Japan</nlm:aff></affiliation></author><author><name sortKey="Bredeson, Christopher N" sort="Bredeson, Christopher N" uniqKey="Bredeson C" first="Christopher N." last="Bredeson">Christopher N. Bredeson</name><affiliation><nlm:aff id="A23">Department of Medicine, The Ottawa Hospital, Ottawa, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Jacobsohn, David A" sort="Jacobsohn, David A" uniqKey="Jacobsohn D" first="David A." last="Jacobsohn">David A. Jacobsohn</name><affiliation><nlm:aff id="A24">Division of Blood and Marrow Transplantation Center for Cancer and Blood Disorders, Children’s National Health Systems, Washington, DC</nlm:aff></affiliation></author><author><name sortKey="Hayashi, Robert J" sort="Hayashi, Robert J" uniqKey="Hayashi R" first="Robert J." last="Hayashi">Robert J. Hayashi</name><affiliation><nlm:aff id="A25">Division of Pediatric Hematology/Oncology, Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO</nlm:aff></affiliation></author><author><name sortKey="Drobyski, William R" sort="Drobyski, William R" uniqKey="Drobyski W" first="William R." last="Drobyski">William R. Drobyski</name><affiliation><nlm:aff id="A26">Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation></author><author><name sortKey="Frangoul, Haydar A" sort="Frangoul, Haydar A" uniqKey="Frangoul H" first="Haydar A." last="Frangoul">Haydar A. Frangoul</name><affiliation><nlm:aff id="A27">Division of Hematology-Oncology, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN</nlm:aff></affiliation></author><author><name sortKey="Akpek, Gorgun" sort="Akpek, Gorgun" uniqKey="Akpek G" first="Görgün" last="Akpek">Görgün Akpek</name><affiliation><nlm:aff id="A28">Section of Hematology Oncology, Banner MD Anderson Cancer Center, Gilbert, AZ</nlm:aff></affiliation></author><author><name sortKey="Ho, Vincent T" sort="Ho, Vincent T" uniqKey="Ho V" first="Vincent T." last="Ho">Vincent T. Ho</name><affiliation><nlm:aff id="A8">Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Lewis, Victor A" sort="Lewis, Victor A" uniqKey="Lewis V" first="Victor A." last="Lewis">Victor A. Lewis</name><affiliation><nlm:aff id="A29">Departments of Oncology, Paediatrics, Alberta Children’s Hospital, Calgary, AB, Canada</nlm:aff></affiliation></author><author><name sortKey="Gale, Robert Peter" sort="Gale, Robert Peter" uniqKey="Gale R" first="Robert Peter" last="Gale">Robert Peter Gale</name></author><author><name sortKey="Koreth, John" sort="Koreth, John" uniqKey="Koreth J" first="John" last="Koreth">John Koreth</name><affiliation><nlm:aff id="A8">Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Chao, Nelson J" sort="Chao, Nelson J" uniqKey="Chao N" first="Nelson J." last="Chao">Nelson J. Chao</name><affiliation><nlm:aff id="A31">Division of Cell Therapy and Hematologica, Department of Medicine, Duke University Medical Center, Durham, NC</nlm:aff></affiliation></author><author><name sortKey="Aljurf, Mahmoud D" sort="Aljurf, Mahmoud D" uniqKey="Aljurf M" first="Mahmoud D." last="Aljurf">Mahmoud D. Aljurf</name><affiliation><nlm:aff id="A32">Department of Oncology, King Faisal Specialist Hospital Center & Research, Riyadh, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Cooper, Brenda W" sort="Cooper, Brenda W" uniqKey="Cooper B" first="Brenda W." last="Cooper">Brenda W. Cooper</name><affiliation><nlm:aff id="A33">Department of Medicine-Hematology and Oncology, University Hospitals Case Medical Center, Cleveland, OH</nlm:aff></affiliation></author><author><name sortKey="Laughlin, Mary J" sort="Laughlin, Mary J" uniqKey="Laughlin M" first="Mary J." last="Laughlin">Mary J. Laughlin</name><affiliation><nlm:aff id="A34">Medical Director, Cleveland Cord Blood Center, Cleveland, OH</nlm:aff></affiliation></author><author><name sortKey="Hsu, Jack W" sort="Hsu, Jack W" uniqKey="Hsu J" first="Jack W." last="Hsu">Jack W. Hsu</name><affiliation><nlm:aff id="A35">Division of Hematology & Oncology, Department of Medicine, Shands HealthCare & University of Florida, Gainesville, FL</nlm:aff></affiliation></author><author><name sortKey="Hematti, Peiman" sort="Hematti, Peiman" uniqKey="Hematti P" first="Peiman" last="Hematti">Peiman Hematti</name><affiliation><nlm:aff id="A12">Division of Hematology/Oncology/Bone Marrow Transplantation, Department of Medicine, University of Wisconsin Hospital and Clinics, Madison, WI</nlm:aff></affiliation></author><author><name sortKey="Verdonck, Leo F" sort="Verdonck, Leo F" uniqKey="Verdonck L" first="Leo F." last="Verdonck">Leo F. Verdonck</name><affiliation><nlm:aff id="A36">Department of Internal Medicine, Isala Clinics, Zwolle, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Solh, Melhelm M" sort="Solh, Melhelm M" uniqKey="Solh M" first="Melhelm M." last="Solh">Melhelm M. Solh</name><affiliation><nlm:aff id="A37">Flordia Center for Cellular Therapy, Florida Hospital, Orlando, FL</nlm:aff></affiliation></author><author><name sortKey="Norkin, Maxim" sort="Norkin, Maxim" uniqKey="Norkin M" first="Maxim" last="Norkin">Maxim Norkin</name><affiliation><nlm:aff id="A35">Division of Hematology & Oncology, Department of Medicine, Shands HealthCare & University of Florida, Gainesville, FL</nlm:aff></affiliation></author><author><name sortKey="Reddy, Vijay" sort="Reddy, Vijay" uniqKey="Reddy V" first="Vijay" last="Reddy">Vijay Reddy</name><affiliation><nlm:aff id="A38">University of Florida, Gainesville, FL</nlm:aff></affiliation></author><author><name sortKey="Martino, Rodrigo" sort="Martino, Rodrigo" uniqKey="Martino R" first="Rodrigo" last="Martino">Rodrigo Martino</name><affiliation><nlm:aff id="A39">Department of Hematology, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Gadalla, Shahinaz" sort="Gadalla, Shahinaz" uniqKey="Gadalla S" first="Shahinaz" last="Gadalla">Shahinaz Gadalla</name><affiliation><nlm:aff id="A40">Division of Cancer Epidemiology & Genetics, NIH-NCI Clinical Genetics Branch, Rockville, MD</nlm:aff></affiliation></author><author><name sortKey="Goldberg, Jenna D" sort="Goldberg, Jenna D" uniqKey="Goldberg J" first="Jenna D." last="Goldberg">Jenna D. Goldberg</name><affiliation><nlm:aff id="A41">Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY</nlm:aff></affiliation></author><author><name sortKey="Mccarthy, Philip L" sort="Mccarthy, Philip L" uniqKey="Mccarthy P" first="Philip L." last="Mccarthy">Philip L. Mccarthy</name><affiliation><nlm:aff id="A42">Blood & Marrow Transplant Program, Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY</nlm:aff></affiliation></author><author><name sortKey="Perez Sim N, Jose A" sort="Perez Sim N, Jose A" uniqKey="Perez Sim N J" first="José A." last="Pérez-Sim N">José A. Pérez-Sim N</name><affiliation><nlm:aff id="A43">Department of Hematology, Instituto de Biomedicina de Sevilla, Seville, Spain</nlm:aff></affiliation></author><author><name sortKey="Khera, Nandita" sort="Khera, Nandita" uniqKey="Khera N" first="Nandita" last="Khera">Nandita Khera</name><affiliation><nlm:aff id="A44">Department of Hematology/Oncology, Mayo Clinic, Phoenix, AZ</nlm:aff></affiliation></author><author><name sortKey="Lewis, Ian D" sort="Lewis, Ian D" uniqKey="Lewis I" first="Ian D." last="Lewis">Ian D. Lewis</name><affiliation><nlm:aff id="A45">Haematology and Bone Marrow Transplant Unit, Royal Adelaide Hospital, Adelaide, SA, Australia</nlm:aff></affiliation></author><author><name sortKey="Atsuta, Yoshiko" sort="Atsuta, Yoshiko" uniqKey="Atsuta Y" first="Yoshiko" last="Atsuta">Yoshiko Atsuta</name><affiliation><nlm:aff id="A46">Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan</nlm:aff></affiliation><affiliation><nlm:aff id="A47">Nagoya University Graduate School of Medicine, Nagoya, Japan</nlm:aff></affiliation></author><author><name sortKey="Olsson, Richard F" sort="Olsson, Richard F" uniqKey="Olsson R" first="Richard F." last="Olsson">Richard F. Olsson</name><affiliation><nlm:aff id="A48">Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A49">Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name><affiliation><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation></author><author><name sortKey="Waller, Edmund K" sort="Waller, Edmund K" uniqKey="Waller E" first="Edmund K." last="Waller">Edmund K. Waller</name><affiliation><nlm:aff id="A50">Winship Cancer Institute, Emory University, Atlanta, GA</nlm:aff></affiliation></author><author><name sortKey="Blaise, Didier" sort="Blaise, Didier" uniqKey="Blaise D" first="Didier" last="Blaise">Didier Blaise</name><affiliation><nlm:aff id="A51">Deparment of Hematology, Institut Paoli Calmettes, Marseille, France</nlm:aff></affiliation></author><author><name sortKey="Pidala, Joseph A" sort="Pidala, Joseph A" uniqKey="Pidala J" first="Joseph A." last="Pidala">Joseph A. Pidala</name><affiliation><nlm:aff id="A52">H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL</nlm:aff></affiliation></author><author><name sortKey="Martin, Paul J" sort="Martin, Paul J" uniqKey="Martin P" first="Paul J." last="Martin">Paul J. Martin</name><affiliation><nlm:aff id="A13">Divison of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff></affiliation></author><author><name sortKey="Satwani, Prakash" sort="Satwani, Prakash" uniqKey="Satwani P" first="Prakash" last="Satwani">Prakash Satwani</name><affiliation><nlm:aff id="A53">Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Department of Pediatrics, Columbia University Medical Center, New York, NY</nlm:aff></affiliation></author><author><name sortKey="Bornh User, Martin" sort="Bornh User, Martin" uniqKey="Bornh User M" first="Martin" last="Bornh User">Martin Bornh User</name><affiliation><nlm:aff id="A54">Department of Internal Medicine, University Hospital Dresden, Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Inamoto, Yoshihiro" sort="Inamoto, Yoshihiro" uniqKey="Inamoto Y" first="Yoshihiro" last="Inamoto">Yoshihiro Inamoto</name><affiliation><nlm:aff id="A13">Divison of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff></affiliation></author><author><name sortKey="Weisdorf, Daniel J" sort="Weisdorf, Daniel J" uniqKey="Weisdorf D" first="Daniel J." last="Weisdorf">Daniel J. Weisdorf</name><affiliation><nlm:aff id="A2">Division of Hematology, Oncology and Transplant, University of Minnesota Medical Center, Minneapolis, MN</nlm:aff></affiliation></author><author><name sortKey="Horowitz, Mary M" sort="Horowitz, Mary M" uniqKey="Horowitz M" first="Mary M." last="Horowitz">Mary M. Horowitz</name><affiliation><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation></author><author><name sortKey="Pavletic, Steven Z" sort="Pavletic, Steven Z" uniqKey="Pavletic S" first="Steven Z." last="Pavletic">Steven Z. Pavletic</name><affiliation><nlm:aff id="A55">NIH-NCI Experimental Transplantation and Immunology Branch, Bethesda, MD</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25445023</idno><idno type="pmc">4326247</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326247</idno><idno type="RBID">PMC:4326247</idno><idno type="doi">10.1016/j.bbmt.2014.10.021</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002189</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002189</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Increasing Incidence of Chronic Graft-versus-Host Disease in Allogeneic Transplantation – A Report from CIBMTR</title><author><name sortKey="Arai, Sally" sort="Arai, Sally" uniqKey="Arai S" first="Sally" last="Arai">Sally Arai</name><affiliation><nlm:aff id="A1">Division of Bone Marrow Transplant, Stanford University Medical Center, Stanford, CA</nlm:aff></affiliation></author><author><name sortKey="Arora, Mukta" sort="Arora, Mukta" uniqKey="Arora M" first="Mukta" last="Arora">Mukta Arora</name><affiliation><nlm:aff id="A2">Division of Hematology, Oncology and Transplant, University of Minnesota Medical Center, Minneapolis, MN</nlm:aff></affiliation></author><author><name sortKey="Wang, Tao" sort="Wang, Tao" uniqKey="Wang T" first="Tao" last="Wang">Tao Wang</name><affiliation><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation></author><author><name sortKey="Spellman, Stephen R" sort="Spellman, Stephen R" uniqKey="Spellman S" first="Stephen R." last="Spellman">Stephen R. Spellman</name><affiliation><nlm:aff id="A5">Center for International Blood and Marrow Transplant Research, National Marrow Donor Program, Minneapolis, MN</nlm:aff></affiliation></author><author><name sortKey="He, Wensheng" sort="He, Wensheng" uniqKey="He W" first="Wensheng" last="He">Wensheng He</name><affiliation><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation></author><author><name sortKey="Couriel, Daniel R" sort="Couriel, Daniel R" uniqKey="Couriel D" first="Daniel R." last="Couriel">Daniel R. Couriel</name><affiliation><nlm:aff id="A6">Division of Hematology/Oncology, The University of Michigan, Ann Arbor, MI</nlm:aff></affiliation></author><author><name sortKey="Urbano Ispizua, Alvaro" sort="Urbano Ispizua, Alvaro" uniqKey="Urbano Ispizua A" first="Alvaro" last="Urbano-Ispizua">Alvaro Urbano-Ispizua</name><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital Clinic of Barcelona, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Cutler, Corey S" sort="Cutler, Corey S" uniqKey="Cutler C" first="Corey S." last="Cutler">Corey S. Cutler</name><affiliation><nlm:aff id="A8">Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Bacigalupo, Andrea A" sort="Bacigalupo, Andrea A" uniqKey="Bacigalupo A" first="Andrea A." last="Bacigalupo">Andrea A. Bacigalupo</name><affiliation><nlm:aff id="A9">Department of Hematology, IRCCS AOU San Martino-IST, Genoa, Italy</nlm:aff></affiliation></author><author><name sortKey="Battiwalla, Minoo" sort="Battiwalla, Minoo" uniqKey="Battiwalla M" first="Minoo" last="Battiwalla">Minoo Battiwalla</name><affiliation><nlm:aff id="A10">Branch of Hematology, National Heart Lung and Blood Institute, Bethesda, MD</nlm:aff></affiliation></author><author><name sortKey="Flowers, Mary E" sort="Flowers, Mary E" uniqKey="Flowers M" first="Mary E." last="Flowers">Mary E. Flowers</name><affiliation><nlm:aff id="A11">Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA</nlm:aff></affiliation></author><author><name sortKey="Juckett, Mark B" sort="Juckett, Mark B" uniqKey="Juckett M" first="Mark B." last="Juckett">Mark B. Juckett</name><affiliation><nlm:aff id="A12">Division of Hematology/Oncology/Bone Marrow Transplantation, Department of Medicine, University of Wisconsin Hospital and Clinics, Madison, WI</nlm:aff></affiliation></author><author><name sortKey="Lee, Stephanie J" sort="Lee, Stephanie J" uniqKey="Lee S" first="Stephanie J." last="Lee">Stephanie J. Lee</name><affiliation><nlm:aff id="A13">Divison of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff></affiliation></author><author><name sortKey="Loren, Alison W" sort="Loren, Alison W" uniqKey="Loren A" first="Alison W." last="Loren">Alison W. Loren</name><affiliation><nlm:aff id="A14">Division of Hematology/Oncology, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA</nlm:aff></affiliation></author><author><name sortKey="Klumpp, Thomas R" sort="Klumpp, Thomas R" uniqKey="Klumpp T" first="Thomas R." last="Klumpp">Thomas R. Klumpp</name><affiliation><nlm:aff id="A15">Divison of Bone Marrow Transplantation, Temple Bone Marrow Transplant Program, Philadelphia, PA</nlm:aff></affiliation></author><author><name sortKey="Prockup, Susan E" sort="Prockup, Susan E" uniqKey="Prockup S" first="Susan E." last="Prockup">Susan E. Prockup</name><affiliation><nlm:aff id="A16">Divison of Bone Marrow Transplant, Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY</nlm:aff></affiliation></author><author><name sortKey="Ringden, Olle T H" sort="Ringden, Olle T H" uniqKey="Ringden O" first="Olle T. H." last="Ringdén">Olle T. H. Ringdén</name><affiliation><nlm:aff id="A17">Division of Clinical Immunology and Center for Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N." last="Savani">Bipin N. Savani</name><affiliation><nlm:aff id="A18">Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN</nlm:aff></affiliation></author><author><name sortKey="Socie, Gerard" sort="Socie, Gerard" uniqKey="Socie G" first="Gérard" last="Socié">Gérard Socié</name><affiliation><nlm:aff id="A19">Division of Hematology, Hopital Saint Louis, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Schultz, Kirk R" sort="Schultz, Kirk R" uniqKey="Schultz K" first="Kirk R." last="Schultz">Kirk R. Schultz</name><affiliation><nlm:aff id="A20">Department of Pediatric Hematology/Oncology/BMT, British Columbia’s Children’s Hospital, University of British Columbia, Vancouver, British Columbia, Canada</nlm:aff></affiliation></author><author><name sortKey="Spitzer, Thomas" sort="Spitzer, Thomas" uniqKey="Spitzer T" first="Thomas" last="Spitzer">Thomas Spitzer</name><affiliation><nlm:aff id="A21">Department of Bone Marrow Transplant-Oncology, Massachusetts General Hospital, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Teshima, Takanori" sort="Teshima, Takanori" uniqKey="Teshima T" first="Takanori" last="Teshima">Takanori Teshima</name><affiliation><nlm:aff id="A22">Kyushu University Hospital, Fukuoka, Japan</nlm:aff></affiliation></author><author><name sortKey="Bredeson, Christopher N" sort="Bredeson, Christopher N" uniqKey="Bredeson C" first="Christopher N." last="Bredeson">Christopher N. Bredeson</name><affiliation><nlm:aff id="A23">Department of Medicine, The Ottawa Hospital, Ottawa, ON, Canada</nlm:aff></affiliation></author><author><name sortKey="Jacobsohn, David A" sort="Jacobsohn, David A" uniqKey="Jacobsohn D" first="David A." last="Jacobsohn">David A. Jacobsohn</name><affiliation><nlm:aff id="A24">Division of Blood and Marrow Transplantation Center for Cancer and Blood Disorders, Children’s National Health Systems, Washington, DC</nlm:aff></affiliation></author><author><name sortKey="Hayashi, Robert J" sort="Hayashi, Robert J" uniqKey="Hayashi R" first="Robert J." last="Hayashi">Robert J. Hayashi</name><affiliation><nlm:aff id="A25">Division of Pediatric Hematology/Oncology, Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO</nlm:aff></affiliation></author><author><name sortKey="Drobyski, William R" sort="Drobyski, William R" uniqKey="Drobyski W" first="William R." last="Drobyski">William R. Drobyski</name><affiliation><nlm:aff id="A26">Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation></author><author><name sortKey="Frangoul, Haydar A" sort="Frangoul, Haydar A" uniqKey="Frangoul H" first="Haydar A." last="Frangoul">Haydar A. Frangoul</name><affiliation><nlm:aff id="A27">Division of Hematology-Oncology, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN</nlm:aff></affiliation></author><author><name sortKey="Akpek, Gorgun" sort="Akpek, Gorgun" uniqKey="Akpek G" first="Görgün" last="Akpek">Görgün Akpek</name><affiliation><nlm:aff id="A28">Section of Hematology Oncology, Banner MD Anderson Cancer Center, Gilbert, AZ</nlm:aff></affiliation></author><author><name sortKey="Ho, Vincent T" sort="Ho, Vincent T" uniqKey="Ho V" first="Vincent T." last="Ho">Vincent T. Ho</name><affiliation><nlm:aff id="A8">Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Lewis, Victor A" sort="Lewis, Victor A" uniqKey="Lewis V" first="Victor A." last="Lewis">Victor A. Lewis</name><affiliation><nlm:aff id="A29">Departments of Oncology, Paediatrics, Alberta Children’s Hospital, Calgary, AB, Canada</nlm:aff></affiliation></author><author><name sortKey="Gale, Robert Peter" sort="Gale, Robert Peter" uniqKey="Gale R" first="Robert Peter" last="Gale">Robert Peter Gale</name></author><author><name sortKey="Koreth, John" sort="Koreth, John" uniqKey="Koreth J" first="John" last="Koreth">John Koreth</name><affiliation><nlm:aff id="A8">Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Chao, Nelson J" sort="Chao, Nelson J" uniqKey="Chao N" first="Nelson J." last="Chao">Nelson J. Chao</name><affiliation><nlm:aff id="A31">Division of Cell Therapy and Hematologica, Department of Medicine, Duke University Medical Center, Durham, NC</nlm:aff></affiliation></author><author><name sortKey="Aljurf, Mahmoud D" sort="Aljurf, Mahmoud D" uniqKey="Aljurf M" first="Mahmoud D." last="Aljurf">Mahmoud D. Aljurf</name><affiliation><nlm:aff id="A32">Department of Oncology, King Faisal Specialist Hospital Center & Research, Riyadh, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Cooper, Brenda W" sort="Cooper, Brenda W" uniqKey="Cooper B" first="Brenda W." last="Cooper">Brenda W. Cooper</name><affiliation><nlm:aff id="A33">Department of Medicine-Hematology and Oncology, University Hospitals Case Medical Center, Cleveland, OH</nlm:aff></affiliation></author><author><name sortKey="Laughlin, Mary J" sort="Laughlin, Mary J" uniqKey="Laughlin M" first="Mary J." last="Laughlin">Mary J. Laughlin</name><affiliation><nlm:aff id="A34">Medical Director, Cleveland Cord Blood Center, Cleveland, OH</nlm:aff></affiliation></author><author><name sortKey="Hsu, Jack W" sort="Hsu, Jack W" uniqKey="Hsu J" first="Jack W." last="Hsu">Jack W. Hsu</name><affiliation><nlm:aff id="A35">Division of Hematology & Oncology, Department of Medicine, Shands HealthCare & University of Florida, Gainesville, FL</nlm:aff></affiliation></author><author><name sortKey="Hematti, Peiman" sort="Hematti, Peiman" uniqKey="Hematti P" first="Peiman" last="Hematti">Peiman Hematti</name><affiliation><nlm:aff id="A12">Division of Hematology/Oncology/Bone Marrow Transplantation, Department of Medicine, University of Wisconsin Hospital and Clinics, Madison, WI</nlm:aff></affiliation></author><author><name sortKey="Verdonck, Leo F" sort="Verdonck, Leo F" uniqKey="Verdonck L" first="Leo F." last="Verdonck">Leo F. Verdonck</name><affiliation><nlm:aff id="A36">Department of Internal Medicine, Isala Clinics, Zwolle, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Solh, Melhelm M" sort="Solh, Melhelm M" uniqKey="Solh M" first="Melhelm M." last="Solh">Melhelm M. Solh</name><affiliation><nlm:aff id="A37">Flordia Center for Cellular Therapy, Florida Hospital, Orlando, FL</nlm:aff></affiliation></author><author><name sortKey="Norkin, Maxim" sort="Norkin, Maxim" uniqKey="Norkin M" first="Maxim" last="Norkin">Maxim Norkin</name><affiliation><nlm:aff id="A35">Division of Hematology & Oncology, Department of Medicine, Shands HealthCare & University of Florida, Gainesville, FL</nlm:aff></affiliation></author><author><name sortKey="Reddy, Vijay" sort="Reddy, Vijay" uniqKey="Reddy V" first="Vijay" last="Reddy">Vijay Reddy</name><affiliation><nlm:aff id="A38">University of Florida, Gainesville, FL</nlm:aff></affiliation></author><author><name sortKey="Martino, Rodrigo" sort="Martino, Rodrigo" uniqKey="Martino R" first="Rodrigo" last="Martino">Rodrigo Martino</name><affiliation><nlm:aff id="A39">Department of Hematology, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Gadalla, Shahinaz" sort="Gadalla, Shahinaz" uniqKey="Gadalla S" first="Shahinaz" last="Gadalla">Shahinaz Gadalla</name><affiliation><nlm:aff id="A40">Division of Cancer Epidemiology & Genetics, NIH-NCI Clinical Genetics Branch, Rockville, MD</nlm:aff></affiliation></author><author><name sortKey="Goldberg, Jenna D" sort="Goldberg, Jenna D" uniqKey="Goldberg J" first="Jenna D." last="Goldberg">Jenna D. Goldberg</name><affiliation><nlm:aff id="A41">Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY</nlm:aff></affiliation></author><author><name sortKey="Mccarthy, Philip L" sort="Mccarthy, Philip L" uniqKey="Mccarthy P" first="Philip L." last="Mccarthy">Philip L. Mccarthy</name><affiliation><nlm:aff id="A42">Blood & Marrow Transplant Program, Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY</nlm:aff></affiliation></author><author><name sortKey="Perez Sim N, Jose A" sort="Perez Sim N, Jose A" uniqKey="Perez Sim N J" first="José A." last="Pérez-Sim N">José A. Pérez-Sim N</name><affiliation><nlm:aff id="A43">Department of Hematology, Instituto de Biomedicina de Sevilla, Seville, Spain</nlm:aff></affiliation></author><author><name sortKey="Khera, Nandita" sort="Khera, Nandita" uniqKey="Khera N" first="Nandita" last="Khera">Nandita Khera</name><affiliation><nlm:aff id="A44">Department of Hematology/Oncology, Mayo Clinic, Phoenix, AZ</nlm:aff></affiliation></author><author><name sortKey="Lewis, Ian D" sort="Lewis, Ian D" uniqKey="Lewis I" first="Ian D." last="Lewis">Ian D. Lewis</name><affiliation><nlm:aff id="A45">Haematology and Bone Marrow Transplant Unit, Royal Adelaide Hospital, Adelaide, SA, Australia</nlm:aff></affiliation></author><author><name sortKey="Atsuta, Yoshiko" sort="Atsuta, Yoshiko" uniqKey="Atsuta Y" first="Yoshiko" last="Atsuta">Yoshiko Atsuta</name><affiliation><nlm:aff id="A46">Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan</nlm:aff></affiliation><affiliation><nlm:aff id="A47">Nagoya University Graduate School of Medicine, Nagoya, Japan</nlm:aff></affiliation></author><author><name sortKey="Olsson, Richard F" sort="Olsson, Richard F" uniqKey="Olsson R" first="Richard F." last="Olsson">Richard F. Olsson</name><affiliation><nlm:aff id="A48">Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A49">Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name><affiliation><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation></author><author><name sortKey="Waller, Edmund K" sort="Waller, Edmund K" uniqKey="Waller E" first="Edmund K." last="Waller">Edmund K. Waller</name><affiliation><nlm:aff id="A50">Winship Cancer Institute, Emory University, Atlanta, GA</nlm:aff></affiliation></author><author><name sortKey="Blaise, Didier" sort="Blaise, Didier" uniqKey="Blaise D" first="Didier" last="Blaise">Didier Blaise</name><affiliation><nlm:aff id="A51">Deparment of Hematology, Institut Paoli Calmettes, Marseille, France</nlm:aff></affiliation></author><author><name sortKey="Pidala, Joseph A" sort="Pidala, Joseph A" uniqKey="Pidala J" first="Joseph A." last="Pidala">Joseph A. Pidala</name><affiliation><nlm:aff id="A52">H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL</nlm:aff></affiliation></author><author><name sortKey="Martin, Paul J" sort="Martin, Paul J" uniqKey="Martin P" first="Paul J." last="Martin">Paul J. Martin</name><affiliation><nlm:aff id="A13">Divison of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff></affiliation></author><author><name sortKey="Satwani, Prakash" sort="Satwani, Prakash" uniqKey="Satwani P" first="Prakash" last="Satwani">Prakash Satwani</name><affiliation><nlm:aff id="A53">Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Department of Pediatrics, Columbia University Medical Center, New York, NY</nlm:aff></affiliation></author><author><name sortKey="Bornh User, Martin" sort="Bornh User, Martin" uniqKey="Bornh User M" first="Martin" last="Bornh User">Martin Bornh User</name><affiliation><nlm:aff id="A54">Department of Internal Medicine, University Hospital Dresden, Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Inamoto, Yoshihiro" sort="Inamoto, Yoshihiro" uniqKey="Inamoto Y" first="Yoshihiro" last="Inamoto">Yoshihiro Inamoto</name><affiliation><nlm:aff id="A13">Divison of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff></affiliation></author><author><name sortKey="Weisdorf, Daniel J" sort="Weisdorf, Daniel J" uniqKey="Weisdorf D" first="Daniel J." last="Weisdorf">Daniel J. Weisdorf</name><affiliation><nlm:aff id="A2">Division of Hematology, Oncology and Transplant, University of Minnesota Medical Center, Minneapolis, MN</nlm:aff></affiliation></author><author><name sortKey="Horowitz, Mary M" sort="Horowitz, Mary M" uniqKey="Horowitz M" first="Mary M." last="Horowitz">Mary M. Horowitz</name><affiliation><nlm:aff id="A3">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff></affiliation></author><author><name sortKey="Pavletic, Steven Z" sort="Pavletic, Steven Z" uniqKey="Pavletic S" first="Steven Z." last="Pavletic">Steven Z. Pavletic</name><affiliation><nlm:aff id="A55">NIH-NCI Experimental Transplantation and Immunology Branch, Bethesda, MD</nlm:aff></affiliation></author></analytic><series><title level="j">Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</title><idno type="ISSN">1083-8791</idno><idno type="eISSN">1523-6536</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P3">Although transplant practices have changed over the last decades there is no information on trends in incidence and outcome of cGVHD over time. This study utilized the central database of the Center for International Blood and Marrow Transplant Research (CIBMTR) to describe the time trends for cGVHD incidence, non-relapse mortality, and the risk factors for cGVHD. The 12-year period was divided into three intervals: 1995-1999, 2000-2003, 2004-2007, and included 26,563 patients with acute leukemia, chronic myeloid leukemia and myelodysplastic syndrome. In the multivariate analysis, the incidence of cGVHD was shown to be increased in more recent years (odds ratio= 1.19, p<0.0001) and this trend was still seen when adjusting for donor type, graft type, or conditioning intensity. In patients with cGVHD, non-relapse mortality has decreased over time, but at 5-years there were no significant differences among different time periods. Risk factors for cGVHD were in line with previous studies. This is the first comprehensive characterization of the trends in cGVHD incidence and underscores the mounting need for addressing this major late complication of transplantation in future research.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9600628</journal-id><journal-id journal-id-type="pubmed-jr-id">20830</journal-id><journal-id journal-id-type="nlm-ta">Biol Blood Marrow Transplant</journal-id><journal-id journal-id-type="iso-abbrev">Biol. Blood Marrow Transplant.</journal-id><journal-title-group><journal-title>Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</journal-title></journal-title-group><issn pub-type="ppub">1083-8791</issn><issn pub-type="epub">1523-6536</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25445023</article-id><article-id pub-id-type="pmc">4326247</article-id><article-id pub-id-type="doi">10.1016/j.bbmt.2014.10.021</article-id><article-id pub-id-type="manuscript">NIHMS650777</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Increasing Incidence of Chronic Graft-versus-Host Disease in Allogeneic Transplantation – A Report from CIBMTR</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Arai</surname><given-names>Sally</given-names></name><degrees>MD</degrees><xref 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contrib-type="author"><name><surname>Goldberg</surname><given-names>Jenna D.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A41">41</xref></contrib><contrib contrib-type="author"><name><surname>McCarthy</surname><given-names>Philip L.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A42">42</xref></contrib><contrib contrib-type="author"><name><surname>Pérez-Simón</surname><given-names>José A.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A43">43</xref></contrib><contrib contrib-type="author"><name><surname>Khera</surname><given-names>Nandita</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A44">44</xref></contrib><contrib contrib-type="author"><name><surname>Lewis</surname><given-names>Ian D.</given-names></name><degrees>MBBS, PhD</degrees><xref ref-type="aff" rid="A45">45</xref></contrib><contrib contrib-type="author"><name><surname>Atsuta</surname><given-names>Yoshiko</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A46">46</xref><xref ref-type="aff" rid="A47">47</xref></contrib><contrib contrib-type="author"><name><surname>Olsson</surname><given-names>Richard F.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A48">48</xref><xref ref-type="aff" rid="A49">49</xref></contrib><contrib contrib-type="author"><name><surname>Saber</surname><given-names>Wael</given-names></name><degrees>MD, MS</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Waller</surname><given-names>Edmund K.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A50">50</xref></contrib><contrib contrib-type="author"><name><surname>Blaise</surname><given-names>Didier</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A51">51</xref></contrib><contrib contrib-type="author"><name><surname>Pidala</surname><given-names>Joseph A.</given-names></name><degrees>MD, MS</degrees><xref ref-type="aff" rid="A52">52</xref></contrib><contrib contrib-type="author"><name><surname>Martin</surname><given-names>Paul J.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Satwani</surname><given-names>Prakash</given-names></name><degrees>MBBS, MD</degrees><xref ref-type="aff" rid="A53">53</xref></contrib><contrib contrib-type="author"><name><surname>Bornhäuser</surname><given-names>Martin</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A54">54</xref></contrib><contrib contrib-type="author"><name><surname>Inamoto</surname><given-names>Yoshihiro</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Weisdorf</surname><given-names>Daniel J.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Horowitz</surname><given-names>Mary M.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Pavletic</surname><given-names>Steven Z.</given-names></name><xref ref-type="aff" rid="A55">55</xref></contrib><on-behalf-of>for the Graft-vs-Host Disease Working Committee of the CIBMTR</on-behalf-of></contrib-group><aff id="A1"><label>1</label>Division of Bone Marrow Transplant, Stanford University Medical Center, Stanford, CA</aff><aff id="A2"><label>2</label>Division of Hematology, Oncology and Transplant, University of Minnesota Medical Center, Minneapolis, MN</aff><aff id="A3"><label>3</label>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</aff><aff id="A4"><label>4</label>Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI</aff><aff id="A5"><label>5</label>Center for International Blood and Marrow Transplant Research, National Marrow Donor Program, Minneapolis, MN</aff><aff id="A6"><label>6</label>Division of Hematology/Oncology, The University of Michigan, Ann Arbor, MI</aff><aff id="A7"><label>7</label>Division of Hematology/Oncology, Hospital Clinic of Barcelona, Barcelona, Spain</aff><aff id="A8"><label>8</label>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA</aff><aff id="A9"><label>9</label>Department of Hematology, IRCCS AOU San Martino-IST, Genoa, Italy</aff><aff id="A10"><label>10</label>Branch of Hematology, National Heart Lung and Blood Institute, Bethesda, MD</aff><aff id="A11"><label>11</label>Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA</aff><aff id="A12"><label>12</label>Division of Hematology/Oncology/Bone Marrow Transplantation, Department of Medicine, University of Wisconsin Hospital and Clinics, Madison, WI</aff><aff id="A13"><label>13</label>Divison of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA</aff><aff id="A14"><label>14</label>Division of Hematology/Oncology, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA</aff><aff id="A15"><label>15</label>Divison of Bone Marrow Transplantation, Temple Bone Marrow Transplant Program, Philadelphia, PA</aff><aff id="A16"><label>16</label>Divison of Bone Marrow Transplant, Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY</aff><aff id="A17"><label>17</label>Division of Clinical Immunology and Center for Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Stockholm, Sweden</aff><aff id="A18"><label>18</label>Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN</aff><aff id="A19"><label>19</label>Division of Hematology, Hopital Saint Louis, Paris, France</aff><aff id="A20"><label>20</label>Department of Pediatric Hematology/Oncology/BMT, British Columbia’s Children’s Hospital, University of British Columbia, Vancouver, British Columbia, Canada</aff><aff id="A21"><label>21</label>Department of Bone Marrow Transplant-Oncology, Massachusetts General Hospital, Boston, MA</aff><aff id="A22"><label>22</label>Kyushu University Hospital, Fukuoka, Japan</aff><aff id="A23"><label>23</label>Department of Medicine, The Ottawa Hospital, Ottawa, ON, Canada</aff><aff id="A24"><label>24</label>Division of Blood and Marrow Transplantation Center for Cancer and Blood Disorders, Children’s National Health Systems, Washington, DC</aff><aff id="A25"><label>25</label>Division of Pediatric Hematology/Oncology, Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO</aff><aff id="A26"><label>26</label>Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI</aff><aff id="A27"><label>27</label>Division of Hematology-Oncology, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN</aff><aff id="A28"><label>28</label>Section of Hematology Oncology, Banner MD Anderson Cancer Center, Gilbert, AZ</aff><aff id="A29"><label>29</label>Departments of Oncology, Paediatrics, Alberta Children’s Hospital, Calgary, AB, Canada</aff><aff id="A30"><label>30</label>Hematology Research Centre, Division of Experimental Medicine, Department of Medicine, Imperial College London, London, United Kingdom</aff><aff id="A31"><label>31</label>Division of Cell Therapy and Hematologica, Department of Medicine, Duke University Medical Center, Durham, NC</aff><aff id="A32"><label>32</label>Department of Oncology, King Faisal Specialist Hospital Center & Research, Riyadh, Saudi Arabia</aff><aff id="A33"><label>33</label>Department of Medicine-Hematology and Oncology, University Hospitals Case Medical Center, Cleveland, OH</aff><aff id="A34"><label>34</label>Medical Director, Cleveland Cord Blood Center, Cleveland, OH</aff><aff id="A35"><label>35</label>Division of Hematology & Oncology, Department of Medicine, Shands HealthCare & University of Florida, Gainesville, FL</aff><aff id="A36"><label>36</label>Department of Internal Medicine, Isala Clinics, Zwolle, Netherlands</aff><aff id="A37"><label>37</label>Flordia Center for Cellular Therapy, Florida Hospital, Orlando, FL</aff><aff id="A38"><label>38</label>University of Florida, Gainesville, FL</aff><aff id="A39"><label>39</label>Department of Hematology, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain</aff><aff id="A40"><label>40</label>Division of Cancer Epidemiology & Genetics, NIH-NCI Clinical Genetics Branch, Rockville, MD</aff><aff id="A41"><label>41</label>Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY</aff><aff id="A42"><label>42</label>Blood & Marrow Transplant Program, Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY</aff><aff id="A43"><label>43</label>Department of Hematology, Instituto de Biomedicina de Sevilla, Seville, Spain</aff><aff id="A44"><label>44</label>Department of Hematology/Oncology, Mayo Clinic, Phoenix, AZ</aff><aff id="A45"><label>45</label>Haematology and Bone Marrow Transplant Unit, Royal Adelaide Hospital, Adelaide, SA, Australia</aff><aff id="A46"><label>46</label>Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan</aff><aff id="A47"><label>47</label>Nagoya University Graduate School of Medicine, Nagoya, Japan</aff><aff id="A48"><label>48</label>Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A49"><label>49</label>Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden</aff><aff id="A50"><label>50</label>Winship Cancer Institute, Emory University, Atlanta, GA</aff><aff id="A51"><label>51</label>Deparment of Hematology, Institut Paoli Calmettes, Marseille, France</aff><aff id="A52"><label>52</label>H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL</aff><aff id="A53"><label>53</label>Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Department of Pediatrics, Columbia University Medical Center, New York, NY</aff><aff id="A54"><label>54</label>Department of Internal Medicine, University Hospital Dresden, Dresden, Germany</aff><aff id="A55"><label>55</label>NIH-NCI Experimental Transplantation and Immunology Branch, Bethesda, MD</aff><author-notes><corresp id="CR1"><bold>Corresponding Author:</bold> Steven Pavletic, MD, MS; NIH-NCI Experimental Transplantation and Immunology Branch, 9000 Rockville Pike, Building 10 CRC Room 3E-3330, MSC-1203, Bethesda, MD 20892; Telephone: 301-402-4899; Fax: 301-480-3444; <email>pavletis@mail.nih.gov</email></corresp><fn id="FN3"><p id="P1"><bold>Authorship</bold></p><p id="P2"><italic>Contribution:</italic> SA, MA, SP designed the study. TW, WH and MA analyzed and interpreted the data. SA and SP drafted the manuscript. MA, TW, SS, WH and other co-authors critically reviewed the manuscript. All authors approved the manuscript.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>31</day><month>1</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>30</day><month>10</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>2</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>2</month><year>2016</year></pub-date><volume>21</volume><issue>2</issue><fpage>266</fpage><lpage>274</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.bbmt.2014.10.021</pmc-comment>
<abstract><p id="P3">Although transplant practices have changed over the last decades there is no information on trends in incidence and outcome of cGVHD over time. This study utilized the central database of the Center for International Blood and Marrow Transplant Research (CIBMTR) to describe the time trends for cGVHD incidence, non-relapse mortality, and the risk factors for cGVHD. The 12-year period was divided into three intervals: 1995-1999, 2000-2003, 2004-2007, and included 26,563 patients with acute leukemia, chronic myeloid leukemia and myelodysplastic syndrome. In the multivariate analysis, the incidence of cGVHD was shown to be increased in more recent years (odds ratio= 1.19, p<0.0001) and this trend was still seen when adjusting for donor type, graft type, or conditioning intensity. In patients with cGVHD, non-relapse mortality has decreased over time, but at 5-years there were no significant differences among different time periods. Risk factors for cGVHD were in line with previous studies. This is the first comprehensive characterization of the trends in cGVHD incidence and underscores the mounting need for addressing this major late complication of transplantation in future research.</p></abstract><kwd-group><kwd>incidence</kwd><kwd>cGVHD</kwd><kwd>allogeneic transplant</kwd><kwd>non-relapse mortality</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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