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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma</title><author><name sortKey="Chambers, John C" sort="Chambers, John C" uniqKey="Chambers J" first="John C" last="Chambers">John C. Chambers</name><affiliation><nlm:aff id="A1">Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Imperial College Healthcare National Health Service (NHS) Trust, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Ealing Hospital NHS Trust, Middlesex, UK</nlm:aff></affiliation></author><author><name sortKey="Zhang, Weihua" sort="Zhang, Weihua" uniqKey="Zhang W" first="Weihua" last="Zhang">Weihua Zhang</name><affiliation><nlm:aff id="A1">Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Ealing Hospital NHS Trust, Middlesex, UK</nlm:aff></affiliation></author><author><name sortKey="Sehmi, Joban" sort="Sehmi, Joban" uniqKey="Sehmi J" first="Joban" last="Sehmi">Joban Sehmi</name><affiliation><nlm:aff id="A3">Ealing Hospital NHS Trust, Middlesex, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A4">National Heart and Lung Institute, Imperial College London, Hammersmith Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Li, Xinzhong" sort="Li, Xinzhong" uniqKey="Li X" first="Xinzhong" last="Li">Xinzhong Li</name><affiliation><nlm:aff id="A5">Institute of Clinical Science, Imperial College London, Royal Brompton Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Wass, Mark N" sort="Wass, Mark N" uniqKey="Wass M" first="Mark N" last="Wass">Mark N. Wass</name><affiliation><nlm:aff id="A6">Structural Bioinformatics Group, Division of Molecular Biosciences, Imperial College London, South Kensington, London, UK</nlm:aff></affiliation></author><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation><nlm:aff id="A7">Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Holm, Hilma" sort="Holm, Hilma" uniqKey="Holm H" first="Hilma" last="Holm">Hilma Holm</name><affiliation><nlm:aff id="A8">deCODE genetics, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Sanna, Serena" sort="Sanna, Serena" uniqKey="Sanna S" first="Serena" last="Sanna">Serena Sanna</name><affiliation><nlm:aff id="A9">Istituto di Ricerca Genetica e Biomedica del Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy</nlm:aff></affiliation></author><author><name sortKey="Kavousi, Maryam" sort="Kavousi, Maryam" uniqKey="Kavousi M" first="Maryam" last="Kavousi">Maryam Kavousi</name><affiliation><nlm:aff id="A10">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Netherlands Genomics Initiative-Sponsored Netherlands Consortium for Health Aging, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Baumeister, Sebastian E" sort="Baumeister, Sebastian E" uniqKey="Baumeister S" first="Sebastian E" last="Baumeister">Sebastian E. Baumeister</name><affiliation><nlm:aff id="A12">Institute for Community Medicine, University of Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Coin, Lachlan J" sort="Coin, Lachlan J" uniqKey="Coin L" first="Lachlan J" last="Coin">Lachlan J. Coin</name><affiliation><nlm:aff id="A1">Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK</nlm:aff></affiliation></author><author><name sortKey="Deng, Guohong" sort="Deng, Guohong" uniqKey="Deng G" first="Guohong" last="Deng">Guohong Deng</name><affiliation><nlm:aff id="A13">Institute of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing, China</nlm:aff></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation><nlm:aff id="A14">Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Heard Costa, Nancy L" sort="Heard Costa, Nancy L" uniqKey="Heard Costa N" first="Nancy L" last="Heard-Costa">Nancy L. Heard-Costa</name><affiliation><nlm:aff id="A15">Department of Neurology, Boston University School of Medicine, Boston Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name><affiliation><nlm:aff id="A16">Department of Biological Psychology, VU University Amsterdam (VUA), Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kuhnel, Brigitte" sort="Kuhnel, Brigitte" uniqKey="Kuhnel B" first="Brigitte" last="Kühnel">Brigitte Kühnel</name><affiliation><nlm:aff id="A14">Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Kumar, Vinod" sort="Kumar, Vinod" uniqKey="Kumar V" first="Vinod" last="Kumar">Vinod Kumar</name><affiliation><nlm:aff id="A17">Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Lagou, Vasiliki" sort="Lagou, Vasiliki" uniqKey="Lagou V" first="Vasiliki" last="Lagou">Vasiliki Lagou</name><affiliation><nlm:aff id="A18">Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A19">Wellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Liang, Liming" sort="Liang, Liming" uniqKey="Liang L" first="Liming" last="Liang">Liming Liang</name><affiliation><nlm:aff id="A21">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Luan, Jian N" sort="Luan, Jian N" uniqKey="Luan J" first="Jian N" last="Luan">Jian N Luan</name><affiliation><nlm:aff id="A23">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge UK</nlm:aff></affiliation></author><author><name sortKey="Vidal, Pedro Marques" sort="Vidal, Pedro Marques" uniqKey="Vidal P" first="Pedro Marques" last="Vidal">Pedro Marques Vidal</name><affiliation><nlm:aff id="A24">Institute of Social and Preventive Medicine (IUMSP), University Hospital and University of Lausanne, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Leach, Irene Mateo" sort="Leach, Irene Mateo" uniqKey="Leach I" first="Irene Mateo" last="Leach">Irene Mateo Leach</name><affiliation><nlm:aff id="A7">Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="O Eilly, Paul F" sort="O Eilly, Paul F" uniqKey="O Eilly P" first="Paul F" last="O Eilly">Paul F. O Eilly</name><affiliation><nlm:aff id="A1">Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK</nlm:aff></affiliation></author><author><name sortKey="Peden, John F" sort="Peden, John F" uniqKey="Peden J" first="John F" last="Peden">John F. Peden</name><affiliation><nlm:aff id="A25">Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Rahmioglu, Nilufer" sort="Rahmioglu, Nilufer" uniqKey="Rahmioglu N" first="Nilufer" last="Rahmioglu">Nilufer Rahmioglu</name><affiliation><nlm:aff id="A19">Wellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Soininen, Pasi" sort="Soininen, Pasi" uniqKey="Soininen P" first="Pasi" last="Soininen">Pasi Soininen</name><affiliation><nlm:aff id="A26">Computational Medicine Research Group, Institute of Clinical Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Nuclear Magnetic Resonance (NMR) Metabonomics Laboratory, Department of Biosciences, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Speliotes, Elizabeth K" sort="Speliotes, Elizabeth K" uniqKey="Speliotes E" first="Elizabeth K" last="Speliotes">Elizabeth K. Speliotes</name><affiliation><nlm:aff id="A28">Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A29">Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff></affiliation></author><author><name sortKey="Yuan, Xin" sort="Yuan, Xin" uniqKey="Yuan X" first="Xin" last="Yuan">Xin Yuan</name><affiliation><nlm:aff id="A30">Genetics, GlaxoSmithKline, King of Prussia, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Thorleifsson, Gudmar" sort="Thorleifsson, Gudmar" uniqKey="Thorleifsson G" first="Gudmar" last="Thorleifsson">Gudmar Thorleifsson</name><affiliation><nlm:aff id="A8">deCODE genetics, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Alizadeh, Behrooz Z" sort="Alizadeh, Behrooz Z" uniqKey="Alizadeh B" first="Behrooz Z" last="Alizadeh">Behrooz Z. Alizadeh</name><affiliation><nlm:aff id="A18">Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Atwood, Larry D" sort="Atwood, Larry D" uniqKey="Atwood L" first="Larry D" last="Atwood">Larry D. Atwood</name><affiliation><nlm:aff id="A31">Boston University School of Medicine, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Borecki, Ingrid B" sort="Borecki, Ingrid B" uniqKey="Borecki I" first="Ingrid B" last="Borecki">Ingrid B. Borecki</name><affiliation><nlm:aff id="A32">Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, Saint Louis, Missouri, USA</nlm:aff></affiliation></author><author><name sortKey="Brown, Morris J" sort="Brown, Morris J" uniqKey="Brown M" first="Morris J" last="Brown">Morris J. Brown</name><affiliation><nlm:aff id="A33">The Diabetes Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Charoen, Pimphen" sort="Charoen, Pimphen" uniqKey="Charoen P" first="Pimphen" last="Charoen">Pimphen Charoen</name><affiliation><nlm:aff id="A1">Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A34">Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand</nlm:aff></affiliation></author><author><name sortKey="Cucca, Francesco" sort="Cucca, Francesco" uniqKey="Cucca F" first="Francesco" last="Cucca">Francesco Cucca</name><affiliation><nlm:aff id="A9">Istituto di Ricerca Genetica e Biomedica del Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy</nlm:aff></affiliation></author><author><name sortKey="Das, Debashish" sort="Das, Debashish" uniqKey="Das D" first="Debashish" last="Das">Debashish Das</name><affiliation><nlm:aff id="A3">Ealing Hospital NHS Trust, Middlesex, UK</nlm:aff></affiliation></author><author><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J C" last="De Geus">Eco J C. De Geus</name><affiliation><nlm:aff id="A16">Department of Biological Psychology, VU University Amsterdam (VUA), Amsterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A35">Neuroscience Campus Amsterdam, VUA and VUA Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Dixon, Anna L" sort="Dixon, Anna L" uniqKey="Dixon A" first="Anna L" last="Dixon">Anna L. Dixon</name><affiliation><nlm:aff id="A36">National Heart and Lung Institute, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Doring, Angela" sort="Doring, Angela" uniqKey="Doring A" first="Angela" last="Döring">Angela Döring</name><affiliation><nlm:aff id="A37">Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Ehret, Georg" sort="Ehret, Georg" uniqKey="Ehret G" first="Georg" last="Ehret">Georg Ehret</name><affiliation><nlm:aff id="A38">Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A39">IUMSP, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Cardiology, Department of Medicine, Geneva University Hospital, Geneva, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Eyjolfsson, Gudmundur I" sort="Eyjolfsson, Gudmundur I" uniqKey="Eyjolfsson G" first="Gudmundur I" last="Eyjolfsson">Gudmundur I. Eyjolfsson</name><affiliation><nlm:aff id="A41">The Laboratory in Mjodd, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Farrall, Martin" sort="Farrall, Martin" uniqKey="Farrall M" first="Martin" last="Farrall">Martin Farrall</name><affiliation><nlm:aff id="A25">Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A42">Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Forouhi, Nita G" sort="Forouhi, Nita G" uniqKey="Forouhi N" first="Nita G" last="Forouhi">Nita G. Forouhi</name><affiliation><nlm:aff id="A23">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge UK</nlm:aff></affiliation></author><author><name sortKey="Friedrich, Nele" sort="Friedrich, Nele" uniqKey="Friedrich N" first="Nele" last="Friedrich">Nele Friedrich</name><affiliation><nlm:aff id="A43">Institute of Clinical Chemistry and Laboratory Medicine, University of Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Goessling, Wolfram" sort="Goessling, Wolfram" uniqKey="Goessling W" first="Wolfram" last="Goessling">Wolfram Goessling</name><affiliation><nlm:aff id="A44">Genetics and Gastroenterology Divisions, Brigham and Women’s Hospital, Gastrointestinal Cancer Center, Dana-Farber Cancer Institute, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A45">Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A46">Harvard Stem Cell Institute, Cambridge, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Gudbjartsson, Daniel F" sort="Gudbjartsson, Daniel F" uniqKey="Gudbjartsson D" first="Daniel F" last="Gudbjartsson">Daniel F. Gudbjartsson</name><affiliation><nlm:aff id="A8">deCODE genetics, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B" last="Harris">Tamara B. Harris</name><affiliation><nlm:aff id="A47">Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, US National Institutes of Health (NIH), Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation><nlm:aff id="A48">Institute of Clinical Medicine, University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Heath, Simon" sort="Heath, Simon" uniqKey="Heath S" first="Simon" last="Heath">Simon Heath</name><affiliation><nlm:aff id="A49">CEA-IG Centre National de Genotypage, Evry Cedex, France</nlm:aff></affiliation></author><author><name sortKey="Hirschfield, Gideon M" sort="Hirschfield, Gideon M" uniqKey="Hirschfield G" first="Gideon M" last="Hirschfield">Gideon M. Hirschfield</name><affiliation><nlm:aff id="A50">Department of Medicine, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A51">Liver Center, Toronto Western Hospital, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A52">Centre for Liver Research, University of Birmingham, Birmingham, UK</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="A10">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Netherlands Genomics Initiative-Sponsored Netherlands Consortium for Health Aging, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Homuth, Georg" sort="Homuth, Georg" uniqKey="Homuth G" first="Georg" last="Homuth">Georg Homuth</name><affiliation><nlm:aff id="A53">Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Hypponen, Elina" sort="Hypponen, Elina" uniqKey="Hypponen E" first="Elina" last="Hyppönen">Elina Hyppönen</name><affiliation><nlm:aff id="A54">Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, UK</nlm:aff></affiliation></author><author><name sortKey="Janssen, Harry L A" sort="Janssen, Harry L A" uniqKey="Janssen H" first="Harry L A" last="Janssen">Harry L A. Janssen</name><affiliation><nlm:aff id="A10">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A55">Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Johnson, Toby" sort="Johnson, Toby" uniqKey="Johnson T" first="Toby" last="Johnson">Toby Johnson</name><affiliation><nlm:aff id="A56">Clinical Pharmacology and The Genome Center, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kangas, Antti J" sort="Kangas, Antti J" uniqKey="Kangas A" first="Antti J" last="Kangas">Antti J. Kangas</name><affiliation><nlm:aff id="A26">Computational Medicine Research Group, Institute of Clinical Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Kema, Ido P" sort="Kema, Ido P" uniqKey="Kema I" first="Ido P" last="Kema">Ido P. Kema</name><affiliation><nlm:aff id="A57">Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kuhn, Jens P" sort="Kuhn, Jens P" uniqKey="Kuhn J" first="Jens P" last="Kühn">Jens P. Kühn</name><affiliation><nlm:aff id="A58">Institute of Diagnostic Radiology and Neuroradiology, University of Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Lai, Sandra" sort="Lai, Sandra" uniqKey="Lai S" first="Sandra" last="Lai">Sandra Lai</name><affiliation><nlm:aff id="A9">Istituto di Ricerca Genetica e Biomedica del Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy</nlm:aff></affiliation></author><author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><affiliation><nlm:aff id="A49">CEA-IG Centre National de Genotypage, Evry Cedex, France</nlm:aff></affiliation><affiliation><nlm:aff id="A59">Fondation Jean Dausset Ceph, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Lerch, Markus M" sort="Lerch, Markus M" uniqKey="Lerch M" first="Markus M" last="Lerch">Markus M. Lerch</name><affiliation><nlm:aff id="A60">Department of Medicine A, University Medicine Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Li, Yun" sort="Li, Yun" uniqKey="Li Y" first="Yun" last="Li">Yun Li</name><affiliation><nlm:aff id="A61">Department of Genetics, Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina, USA</nlm:aff></affiliation></author><author><name sortKey="Liang, T Jake" sort="Liang, T Jake" uniqKey="Liang T" first="T Jake" last="Liang">T Jake Liang</name><affiliation><nlm:aff id="A62">Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Lin, Jing Ping" sort="Lin, Jing Ping" uniqKey="Lin J" first="Jing-Ping" last="Lin">Jing-Ping Lin</name><affiliation><nlm:aff id="A63">Office of Biostatistics Research, Division of Cardiovascular Sciences, National Heart, Lung and Blood Institute (NHLBI), NIH, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Loos, Ruth J F" sort="Loos, Ruth J F" uniqKey="Loos R" first="Ruth J F" last="Loos">Ruth J F. Loos</name><affiliation><nlm:aff id="A23">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge UK</nlm:aff></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name><affiliation><nlm:aff id="A64">Queensland Institute of Medical Research, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Moffatt, Miriam F" sort="Moffatt, Miriam F" uniqKey="Moffatt M" first="Miriam F" last="Moffatt">Miriam F. Moffatt</name><affiliation><nlm:aff id="A36">National Heart and Lung Institute, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W" last="Montgomery">Grant W. Montgomery</name><affiliation><nlm:aff id="A64">Queensland Institute of Medical Research, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Munroe, Patricia B" sort="Munroe, Patricia B" uniqKey="Munroe P" first="Patricia B" last="Munroe">Patricia B. Munroe</name><affiliation><nlm:aff id="A56">Clinical Pharmacology and The Genome Center, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Musunuru, Kiran" sort="Musunuru, Kiran" uniqKey="Musunuru K" first="Kiran" last="Musunuru">Kiran Musunuru</name><affiliation><nlm:aff id="A31">Boston University School of Medicine, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A65">Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A68">Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Nakamura, Yusuke" sort="Nakamura, Yusuke" uniqKey="Nakamura Y" first="Yusuke" last="Nakamura">Yusuke Nakamura</name><affiliation><nlm:aff id="A17">Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="O Onnell, Christopher J" sort="O Onnell, Christopher J" uniqKey="O Onnell C" first="Christopher J" last="O Onnell">Christopher J. O Onnell</name><affiliation><nlm:aff id="A69">NHLBI Framingham Heart Study, Framingham, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Olafsson, Isleifur" sort="Olafsson, Isleifur" uniqKey="Olafsson I" first="Isleifur" last="Olafsson">Isleifur Olafsson</name><affiliation><nlm:aff id="A70">Department of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Penninx, Brenda W" sort="Penninx, Brenda W" uniqKey="Penninx B" first="Brenda W" last="Penninx">Brenda W. Penninx</name><affiliation><nlm:aff id="A71">Department of Psychiatry and EMGO Institute for Health and Care Research, VUA Medical Centre, Amsterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Department of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A73">Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name><affiliation><nlm:aff id="A48">Institute of Clinical Medicine, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A74">Department of Lifecourse and Services, National Institute for Health and Welfare, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Prins, Bram P" sort="Prins, Bram P" uniqKey="Prins B" first="Bram P" last="Prins">Bram P. Prins</name><affiliation><nlm:aff id="A18">Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation><nlm:aff id="A19">Wellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Puls, Ralf" sort="Puls, Ralf" uniqKey="Puls R" first="Ralf" last="Puls">Ralf Puls</name><affiliation><nlm:aff id="A58">Institute of Diagnostic Radiology and Neuroradiology, University of Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Ruokonen, Aimo" sort="Ruokonen, Aimo" uniqKey="Ruokonen A" first="Aimo" last="Ruokonen">Aimo Ruokonen</name><affiliation><nlm:aff id="A75">Institute of Diagnostics, Clinical Chemistry, University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Savolainen, Markku J" sort="Savolainen, Markku J" uniqKey="Savolainen M" first="Markku J" last="Savolainen">Markku J. Savolainen</name><affiliation><nlm:aff id="A26">Computational Medicine Research Group, Institute of Clinical Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A76">Department of Internal Medicine and Biocenter Oulu, Clinical Research Center, University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Schlessinger, David" sort="Schlessinger, David" uniqKey="Schlessinger D" first="David" last="Schlessinger">David Schlessinger</name><affiliation><nlm:aff id="A77">Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Schouten, Jeoffrey N L" sort="Schouten, Jeoffrey N L" uniqKey="Schouten J" first="Jeoffrey N L" last="Schouten">Jeoffrey N L. Schouten</name><affiliation><nlm:aff id="A55">Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Seedorf, Udo" sort="Seedorf, Udo" uniqKey="Seedorf U" first="Udo" last="Seedorf">Udo Seedorf</name><affiliation><nlm:aff id="A78">Gesellschaft für Arterioskleroseforschung, Leibniz-Institut für Arterioskleroseforschung an der Universität Münster, Münster, Germany</nlm:aff></affiliation></author><author><name sortKey="Sen Chowdhry, Srijita" sort="Sen Chowdhry, Srijita" uniqKey="Sen Chowdhry S" first="Srijita" last="Sen-Chowdhry">Srijita Sen-Chowdhry</name><affiliation><nlm:aff id="A1">Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK</nlm:aff></affiliation></author><author><name sortKey="Siminovitch, Katherine A" sort="Siminovitch, Katherine A" uniqKey="Siminovitch K" first="Katherine A" last="Siminovitch">Katherine A. Siminovitch</name><affiliation><nlm:aff id="A50">Department of Medicine, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A79">Department of Immunology, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A80">Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A81">Mount Sinai Hospital Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A82">Toronto General Research Institute, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Smit, Johannes H" sort="Smit, Johannes H" uniqKey="Smit J" first="Johannes H" last="Smit">Johannes H. Smit</name><affiliation><nlm:aff id="A71">Department of Psychiatry and EMGO Institute for Health and Care Research, VUA Medical Centre, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Spector, Timothy D" sort="Spector, Timothy D" uniqKey="Spector T" first="Timothy D" last="Spector">Timothy D. Spector</name><affiliation><nlm:aff id="A83">Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Tan, Wenting" sort="Tan, Wenting" uniqKey="Tan W" first="Wenting" last="Tan">Wenting Tan</name><affiliation><nlm:aff id="A13">Institute of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing, China</nlm:aff></affiliation></author><author><name sortKey="Teslovich, Tanya M" sort="Teslovich, Tanya M" uniqKey="Teslovich T" first="Tanya M" last="Teslovich">Tanya M. Teslovich</name><affiliation><nlm:aff id="A84">Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA</nlm:aff></affiliation></author><author><name sortKey="Tukiainen, Taru" sort="Tukiainen, Taru" uniqKey="Tukiainen T" first="Taru" last="Tukiainen">Taru Tukiainen</name><affiliation><nlm:aff id="A1">Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A26">Computational Medicine Research Group, Institute of Clinical Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G" last="Uitterlinden">Andre G. Uitterlinden</name><affiliation><nlm:aff id="A10">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Netherlands Genomics Initiative-Sponsored Netherlands Consortium for Health Aging, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A85">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Der Klauw, Melanie M" sort="Van Der Klauw, Melanie M" uniqKey="Van Der Klauw M" first="Melanie M" last="Van Der Klauw">Melanie M. Van Der Klauw</name><affiliation><nlm:aff id="A86">Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A87">LifeLines Cohort Study and Biobank, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Vasan, Ramachandran S" sort="Vasan, Ramachandran S" uniqKey="Vasan R" first="Ramachandran S" last="Vasan">Ramachandran S. Vasan</name><affiliation><nlm:aff id="A88">Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A89">Cardiology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Wallace, Chris" sort="Wallace, Chris" uniqKey="Wallace C" first="Chris" last="Wallace">Chris Wallace</name><affiliation><nlm:aff id="A33">The Diabetes Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Wallaschofski, Henri" sort="Wallaschofski, Henri" uniqKey="Wallaschofski H" first="Henri" last="Wallaschofski">Henri Wallaschofski</name><affiliation><nlm:aff id="A43">Institute of Clinical Chemistry and Laboratory Medicine, University of Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H-Erich" last="Wichmann">H-Erich Wichmann</name><affiliation><nlm:aff id="A37">Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A90">Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A91">Klinikum Grosshadern, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name><affiliation><nlm:aff id="A16">Department of Biological Psychology, VU University Amsterdam (VUA), Amsterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A92">EMGO<sup>+</sup>Institute, VUA Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wurtz, Peter" sort="Wurtz, Peter" uniqKey="Wurtz P" first="Peter" last="Würtz">Peter Würtz</name><affiliation><nlm:aff id="A1">Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A26">Computational Medicine Research Group, Institute of Clinical Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Xu, Chun" sort="Xu, Chun" uniqKey="Xu C" first="Chun" last="Xu">Chun Xu</name><affiliation><nlm:aff id="A93">Samuel Lunenfeld and Toronto General Research Institutes, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Yerges Armstrong, Laura M" sort="Yerges Armstrong, Laura M" uniqKey="Yerges Armstrong L" first="Laura M" last="Yerges-Armstrong">Laura M. Yerges-Armstrong</name><affiliation><nlm:aff id="A94">Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Abecasis, Goncalo R" sort="Abecasis, Goncalo R" uniqKey="Abecasis G" first="Goncalo R" last="Abecasis">Goncalo R. Abecasis</name><affiliation><nlm:aff id="A84">Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA</nlm:aff></affiliation></author><author><name sortKey="Ahmadi, Kourosh R" sort="Ahmadi, Kourosh R" uniqKey="Ahmadi K" first="Kourosh R" last="Ahmadi">Kourosh R. Ahmadi</name><affiliation><nlm:aff id="A83">Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I" last="Boomsma">Dorret I. Boomsma</name><affiliation><nlm:aff id="A16">Department of Biological Psychology, VU University Amsterdam (VUA), Amsterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A92">EMGO<sup>+</sup>Institute, VUA Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Caulfield, Mark" sort="Caulfield, Mark" uniqKey="Caulfield M" first="Mark" last="Caulfield">Mark Caulfield</name><affiliation><nlm:aff id="A56">Clinical Pharmacology and The Genome Center, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Cookson, William O" sort="Cookson, William O" uniqKey="Cookson W" first="William O" last="Cookson">William O. Cookson</name><affiliation><nlm:aff id="A36">National Heart and Lung Institute, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><affiliation><nlm:aff id="A10">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Netherlands Genomics Initiative-Sponsored Netherlands Consortium for Health Aging, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A95">Center for Medical Systems Biology, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation><nlm:aff id="A96">Genomics of Common Diseases, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Matsuda, Koichi" sort="Matsuda, Koichi" uniqKey="Matsuda K" first="Koichi" last="Matsuda">Koichi Matsuda</name><affiliation><nlm:aff id="A17">Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I" last="Mccarthy">Mark I. Mccarthy</name><affiliation><nlm:aff id="A19">Wellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A97">Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Meisinger, Christa" sort="Meisinger, Christa" uniqKey="Meisinger C" first="Christa" last="Meisinger">Christa Meisinger</name><affiliation><nlm:aff id="A98">Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Mooser, Vincent" sort="Mooser, Vincent" uniqKey="Mooser V" first="Vincent" last="Mooser">Vincent Mooser</name><affiliation><nlm:aff id="A30">Genetics, GlaxoSmithKline, King of Prussia, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Pietil Inen, Kirsi H" sort="Pietil Inen, Kirsi H" uniqKey="Pietil Inen K" first="Kirsi H" last="Pietil Inen">Kirsi H. Pietil Inen</name><affiliation><nlm:aff id="A99">Obesity Research Unit, Department of Medicine, Division of Internal Medicine, Helsinki University Hospital, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A100">The Institute for Molecular Medicine FIMM, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A101">Hjelt Institute, Department of Public Health, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Schumann, Gunter" sort="Schumann, Gunter" uniqKey="Schumann G" first="Gunter" last="Schumann">Gunter Schumann</name><affiliation><nlm:aff id="A102">MRC-Social Genetic Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, King’s College, London, UK</nlm:aff></affiliation></author><author><name sortKey="Snieder, Harold" sort="Snieder, Harold" uniqKey="Snieder H" first="Harold" last="Snieder">Harold Snieder</name><affiliation><nlm:aff id="A18">Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Sternberg, Michael J E" sort="Sternberg, Michael J E" uniqKey="Sternberg M" first="Michael J E" last="Sternberg">Michael J E. Sternberg</name><affiliation><nlm:aff id="A6">Structural Bioinformatics Group, Division of Molecular Biosciences, Imperial College London, South Kensington, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A87">LifeLines Cohort Study and Biobank, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Stolk, Ronald P" sort="Stolk, Ronald P" uniqKey="Stolk R" first="Ronald P" last="Stolk">Ronald P. Stolk</name><affiliation><nlm:aff id="A103">Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Thomas, Howard C" sort="Thomas, Howard C" uniqKey="Thomas H" first="Howard C" last="Thomas">Howard C. Thomas</name><affiliation><nlm:aff id="A2">Imperial College Healthcare National Health Service (NHS) Trust, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A104">Faculty of Medicine, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation><nlm:aff id="A8">deCODE genetics, Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A105">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Uda, Manuela" sort="Uda, Manuela" uniqKey="Uda M" first="Manuela" last="Uda">Manuela Uda</name><affiliation><nlm:aff id="A9">Istituto di Ricerca Genetica e Biomedica del Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy</nlm:aff></affiliation></author><author><name sortKey="Waeber, Gerard" sort="Waeber, Gerard" uniqKey="Waeber G" first="Gérard" last="Waeber">Gérard Waeber</name><affiliation><nlm:aff id="A106">Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J" last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:aff id="A23">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge UK</nlm:aff></affiliation></author><author><name sortKey="Waterworth, Dawn M" sort="Waterworth, Dawn M" uniqKey="Waterworth D" first="Dawn M" last="Waterworth">Dawn M. Waterworth</name><affiliation><nlm:aff id="A30">Genetics, GlaxoSmithKline, King of Prussia, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Watkins, Hugh" sort="Watkins, Hugh" uniqKey="Watkins H" first="Hugh" last="Watkins">Hugh Watkins</name><affiliation><nlm:aff id="A25">Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A42">Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Whitfield, John B" sort="Whitfield, John B" uniqKey="Whitfield J" first="John B" last="Whitfield">John B. Whitfield</name><affiliation><nlm:aff id="A64">Queensland Institute of Medical Research, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Witteman, Jacqueline C M" sort="Witteman, Jacqueline C M" uniqKey="Witteman J" first="Jacqueline C M" last="Witteman">Jacqueline C M. Witteman</name><affiliation><nlm:aff id="A10">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Netherlands Genomics Initiative-Sponsored Netherlands Consortium for Health Aging, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wolffenbuttel, Bruce H R" sort="Wolffenbuttel, Bruce H R" uniqKey="Wolffenbuttel B" first="Bruce H R" last="Wolffenbuttel">Bruce H R. Wolffenbuttel</name><affiliation><nlm:aff id="A86">Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A87">LifeLines Cohort Study and Biobank, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Fox, Caroline S" sort="Fox, Caroline S" uniqKey="Fox C" first="Caroline S" last="Fox">Caroline S. Fox</name><affiliation><nlm:aff id="A69">NHLBI Framingham Heart Study, Framingham, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A107">Division of Endocrinology, Hypertension, and Metabolism, Brigham and Women’s Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Ala Korpela, Mika" sort="Ala Korpela, Mika" uniqKey="Ala Korpela M" first="Mika" last="Ala-Korpela">Mika Ala-Korpela</name><affiliation><nlm:aff id="A26">Computational Medicine Research Group, Institute of Clinical Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Nuclear Magnetic Resonance (NMR) Metabonomics Laboratory, Department of Biosciences, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A76">Department of Internal Medicine and Biocenter Oulu, Clinical Research Center, University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation><nlm:aff id="A8">deCODE genetics, Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A105">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation><nlm:aff id="A106">Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name><affiliation><nlm:aff id="A12">Institute for Community Medicine, University of Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Schadt, Eric E" sort="Schadt, Eric E" uniqKey="Schadt E" first="Eric E" last="Schadt">Eric E. Schadt</name><affiliation><nlm:aff id="A108">Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Scott, James" sort="Scott, James" uniqKey="Scott J" first="James" last="Scott">James Scott</name><affiliation><nlm:aff id="A4">National Heart and Lung Institute, Imperial College London, Hammersmith Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="J Rvelin, Marjo Riitta" sort="J Rvelin, Marjo Riitta" uniqKey="J Rvelin M" first="Marjo-Riitta" last="J Rvelin">Marjo-Riitta J Rvelin</name><affiliation><nlm:aff id="A1">Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A74">Department of Lifecourse and Services, National Institute for Health and Welfare, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A109">Institute of Health Sciences, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A110">Biocenter Oulu, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A111">MRC–Health Protection Agency (HPA) Centre for Environment and Health, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation><nlm:aff id="A1">Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A111">MRC–Health Protection Agency (HPA) Centre for Environment and Health, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kooner, Jaspal S" sort="Kooner, Jaspal S" uniqKey="Kooner J" first="Jaspal S" last="Kooner">Jaspal S. Kooner</name><affiliation><nlm:aff id="A2">Imperial College Healthcare National Health Service (NHS) Trust, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Ealing Hospital NHS Trust, Middlesex, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A4">National Heart and Lung Institute, Imperial College London, Hammersmith Hospital, London, UK</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22001757</idno><idno type="pmc">3482372</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482372</idno><idno type="RBID">PMC:3482372</idno><idno type="doi">10.1038/ng.970</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">002129</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002129</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma</title><author><name sortKey="Chambers, John C" sort="Chambers, John C" uniqKey="Chambers J" first="John C" last="Chambers">John C. Chambers</name><affiliation><nlm:aff id="A1">Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Imperial College Healthcare National Health Service (NHS) Trust, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Ealing Hospital NHS Trust, Middlesex, UK</nlm:aff></affiliation></author><author><name sortKey="Zhang, Weihua" sort="Zhang, Weihua" uniqKey="Zhang W" first="Weihua" last="Zhang">Weihua Zhang</name><affiliation><nlm:aff id="A1">Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Ealing Hospital NHS Trust, Middlesex, UK</nlm:aff></affiliation></author><author><name sortKey="Sehmi, Joban" sort="Sehmi, Joban" uniqKey="Sehmi J" first="Joban" last="Sehmi">Joban Sehmi</name><affiliation><nlm:aff id="A3">Ealing Hospital NHS Trust, Middlesex, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A4">National Heart and Lung Institute, Imperial College London, Hammersmith Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Li, Xinzhong" sort="Li, Xinzhong" uniqKey="Li X" first="Xinzhong" last="Li">Xinzhong Li</name><affiliation><nlm:aff id="A5">Institute of Clinical Science, Imperial College London, Royal Brompton Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Wass, Mark N" sort="Wass, Mark N" uniqKey="Wass M" first="Mark N" last="Wass">Mark N. Wass</name><affiliation><nlm:aff id="A6">Structural Bioinformatics Group, Division of Molecular Biosciences, Imperial College London, South Kensington, London, UK</nlm:aff></affiliation></author><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation><nlm:aff id="A7">Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Holm, Hilma" sort="Holm, Hilma" uniqKey="Holm H" first="Hilma" last="Holm">Hilma Holm</name><affiliation><nlm:aff id="A8">deCODE genetics, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Sanna, Serena" sort="Sanna, Serena" uniqKey="Sanna S" first="Serena" last="Sanna">Serena Sanna</name><affiliation><nlm:aff id="A9">Istituto di Ricerca Genetica e Biomedica del Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy</nlm:aff></affiliation></author><author><name sortKey="Kavousi, Maryam" sort="Kavousi, Maryam" uniqKey="Kavousi M" first="Maryam" last="Kavousi">Maryam Kavousi</name><affiliation><nlm:aff id="A10">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Netherlands Genomics Initiative-Sponsored Netherlands Consortium for Health Aging, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Baumeister, Sebastian E" sort="Baumeister, Sebastian E" uniqKey="Baumeister S" first="Sebastian E" last="Baumeister">Sebastian E. Baumeister</name><affiliation><nlm:aff id="A12">Institute for Community Medicine, University of Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Coin, Lachlan J" sort="Coin, Lachlan J" uniqKey="Coin L" first="Lachlan J" last="Coin">Lachlan J. Coin</name><affiliation><nlm:aff id="A1">Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK</nlm:aff></affiliation></author><author><name sortKey="Deng, Guohong" sort="Deng, Guohong" uniqKey="Deng G" first="Guohong" last="Deng">Guohong Deng</name><affiliation><nlm:aff id="A13">Institute of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing, China</nlm:aff></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation><nlm:aff id="A14">Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Heard Costa, Nancy L" sort="Heard Costa, Nancy L" uniqKey="Heard Costa N" first="Nancy L" last="Heard-Costa">Nancy L. Heard-Costa</name><affiliation><nlm:aff id="A15">Department of Neurology, Boston University School of Medicine, Boston Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name><affiliation><nlm:aff id="A16">Department of Biological Psychology, VU University Amsterdam (VUA), Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kuhnel, Brigitte" sort="Kuhnel, Brigitte" uniqKey="Kuhnel B" first="Brigitte" last="Kühnel">Brigitte Kühnel</name><affiliation><nlm:aff id="A14">Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Kumar, Vinod" sort="Kumar, Vinod" uniqKey="Kumar V" first="Vinod" last="Kumar">Vinod Kumar</name><affiliation><nlm:aff id="A17">Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Lagou, Vasiliki" sort="Lagou, Vasiliki" uniqKey="Lagou V" first="Vasiliki" last="Lagou">Vasiliki Lagou</name><affiliation><nlm:aff id="A18">Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A19">Wellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Liang, Liming" sort="Liang, Liming" uniqKey="Liang L" first="Liming" last="Liang">Liming Liang</name><affiliation><nlm:aff id="A21">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A22">Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Luan, Jian N" sort="Luan, Jian N" uniqKey="Luan J" first="Jian N" last="Luan">Jian N Luan</name><affiliation><nlm:aff id="A23">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge UK</nlm:aff></affiliation></author><author><name sortKey="Vidal, Pedro Marques" sort="Vidal, Pedro Marques" uniqKey="Vidal P" first="Pedro Marques" last="Vidal">Pedro Marques Vidal</name><affiliation><nlm:aff id="A24">Institute of Social and Preventive Medicine (IUMSP), University Hospital and University of Lausanne, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Leach, Irene Mateo" sort="Leach, Irene Mateo" uniqKey="Leach I" first="Irene Mateo" last="Leach">Irene Mateo Leach</name><affiliation><nlm:aff id="A7">Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="O Eilly, Paul F" sort="O Eilly, Paul F" uniqKey="O Eilly P" first="Paul F" last="O Eilly">Paul F. O Eilly</name><affiliation><nlm:aff id="A1">Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK</nlm:aff></affiliation></author><author><name sortKey="Peden, John F" sort="Peden, John F" uniqKey="Peden J" first="John F" last="Peden">John F. Peden</name><affiliation><nlm:aff id="A25">Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Rahmioglu, Nilufer" sort="Rahmioglu, Nilufer" uniqKey="Rahmioglu N" first="Nilufer" last="Rahmioglu">Nilufer Rahmioglu</name><affiliation><nlm:aff id="A19">Wellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Soininen, Pasi" sort="Soininen, Pasi" uniqKey="Soininen P" first="Pasi" last="Soininen">Pasi Soininen</name><affiliation><nlm:aff id="A26">Computational Medicine Research Group, Institute of Clinical Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Nuclear Magnetic Resonance (NMR) Metabonomics Laboratory, Department of Biosciences, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Speliotes, Elizabeth K" sort="Speliotes, Elizabeth K" uniqKey="Speliotes E" first="Elizabeth K" last="Speliotes">Elizabeth K. Speliotes</name><affiliation><nlm:aff id="A28">Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A29">Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff></affiliation></author><author><name sortKey="Yuan, Xin" sort="Yuan, Xin" uniqKey="Yuan X" first="Xin" last="Yuan">Xin Yuan</name><affiliation><nlm:aff id="A30">Genetics, GlaxoSmithKline, King of Prussia, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Thorleifsson, Gudmar" sort="Thorleifsson, Gudmar" uniqKey="Thorleifsson G" first="Gudmar" last="Thorleifsson">Gudmar Thorleifsson</name><affiliation><nlm:aff id="A8">deCODE genetics, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Alizadeh, Behrooz Z" sort="Alizadeh, Behrooz Z" uniqKey="Alizadeh B" first="Behrooz Z" last="Alizadeh">Behrooz Z. Alizadeh</name><affiliation><nlm:aff id="A18">Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Atwood, Larry D" sort="Atwood, Larry D" uniqKey="Atwood L" first="Larry D" last="Atwood">Larry D. Atwood</name><affiliation><nlm:aff id="A31">Boston University School of Medicine, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Borecki, Ingrid B" sort="Borecki, Ingrid B" uniqKey="Borecki I" first="Ingrid B" last="Borecki">Ingrid B. Borecki</name><affiliation><nlm:aff id="A32">Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, Saint Louis, Missouri, USA</nlm:aff></affiliation></author><author><name sortKey="Brown, Morris J" sort="Brown, Morris J" uniqKey="Brown M" first="Morris J" last="Brown">Morris J. Brown</name><affiliation><nlm:aff id="A33">The Diabetes Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Charoen, Pimphen" sort="Charoen, Pimphen" uniqKey="Charoen P" first="Pimphen" last="Charoen">Pimphen Charoen</name><affiliation><nlm:aff id="A1">Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A34">Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand</nlm:aff></affiliation></author><author><name sortKey="Cucca, Francesco" sort="Cucca, Francesco" uniqKey="Cucca F" first="Francesco" last="Cucca">Francesco Cucca</name><affiliation><nlm:aff id="A9">Istituto di Ricerca Genetica e Biomedica del Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy</nlm:aff></affiliation></author><author><name sortKey="Das, Debashish" sort="Das, Debashish" uniqKey="Das D" first="Debashish" last="Das">Debashish Das</name><affiliation><nlm:aff id="A3">Ealing Hospital NHS Trust, Middlesex, UK</nlm:aff></affiliation></author><author><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J C" last="De Geus">Eco J C. De Geus</name><affiliation><nlm:aff id="A16">Department of Biological Psychology, VU University Amsterdam (VUA), Amsterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A35">Neuroscience Campus Amsterdam, VUA and VUA Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Dixon, Anna L" sort="Dixon, Anna L" uniqKey="Dixon A" first="Anna L" last="Dixon">Anna L. Dixon</name><affiliation><nlm:aff id="A36">National Heart and Lung Institute, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Doring, Angela" sort="Doring, Angela" uniqKey="Doring A" first="Angela" last="Döring">Angela Döring</name><affiliation><nlm:aff id="A37">Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Ehret, Georg" sort="Ehret, Georg" uniqKey="Ehret G" first="Georg" last="Ehret">Georg Ehret</name><affiliation><nlm:aff id="A38">Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A39">IUMSP, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Cardiology, Department of Medicine, Geneva University Hospital, Geneva, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Eyjolfsson, Gudmundur I" sort="Eyjolfsson, Gudmundur I" uniqKey="Eyjolfsson G" first="Gudmundur I" last="Eyjolfsson">Gudmundur I. Eyjolfsson</name><affiliation><nlm:aff id="A41">The Laboratory in Mjodd, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Farrall, Martin" sort="Farrall, Martin" uniqKey="Farrall M" first="Martin" last="Farrall">Martin Farrall</name><affiliation><nlm:aff id="A25">Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A42">Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Forouhi, Nita G" sort="Forouhi, Nita G" uniqKey="Forouhi N" first="Nita G" last="Forouhi">Nita G. Forouhi</name><affiliation><nlm:aff id="A23">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge UK</nlm:aff></affiliation></author><author><name sortKey="Friedrich, Nele" sort="Friedrich, Nele" uniqKey="Friedrich N" first="Nele" last="Friedrich">Nele Friedrich</name><affiliation><nlm:aff id="A43">Institute of Clinical Chemistry and Laboratory Medicine, University of Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Goessling, Wolfram" sort="Goessling, Wolfram" uniqKey="Goessling W" first="Wolfram" last="Goessling">Wolfram Goessling</name><affiliation><nlm:aff id="A44">Genetics and Gastroenterology Divisions, Brigham and Women’s Hospital, Gastrointestinal Cancer Center, Dana-Farber Cancer Institute, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A45">Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A46">Harvard Stem Cell Institute, Cambridge, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Gudbjartsson, Daniel F" sort="Gudbjartsson, Daniel F" uniqKey="Gudbjartsson D" first="Daniel F" last="Gudbjartsson">Daniel F. Gudbjartsson</name><affiliation><nlm:aff id="A8">deCODE genetics, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B" last="Harris">Tamara B. Harris</name><affiliation><nlm:aff id="A47">Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, US National Institutes of Health (NIH), Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation><nlm:aff id="A48">Institute of Clinical Medicine, University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Heath, Simon" sort="Heath, Simon" uniqKey="Heath S" first="Simon" last="Heath">Simon Heath</name><affiliation><nlm:aff id="A49">CEA-IG Centre National de Genotypage, Evry Cedex, France</nlm:aff></affiliation></author><author><name sortKey="Hirschfield, Gideon M" sort="Hirschfield, Gideon M" uniqKey="Hirschfield G" first="Gideon M" last="Hirschfield">Gideon M. Hirschfield</name><affiliation><nlm:aff id="A50">Department of Medicine, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A51">Liver Center, Toronto Western Hospital, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A52">Centre for Liver Research, University of Birmingham, Birmingham, UK</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="A10">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Netherlands Genomics Initiative-Sponsored Netherlands Consortium for Health Aging, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Homuth, Georg" sort="Homuth, Georg" uniqKey="Homuth G" first="Georg" last="Homuth">Georg Homuth</name><affiliation><nlm:aff id="A53">Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Hypponen, Elina" sort="Hypponen, Elina" uniqKey="Hypponen E" first="Elina" last="Hyppönen">Elina Hyppönen</name><affiliation><nlm:aff id="A54">Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, UK</nlm:aff></affiliation></author><author><name sortKey="Janssen, Harry L A" sort="Janssen, Harry L A" uniqKey="Janssen H" first="Harry L A" last="Janssen">Harry L A. Janssen</name><affiliation><nlm:aff id="A10">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A55">Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Johnson, Toby" sort="Johnson, Toby" uniqKey="Johnson T" first="Toby" last="Johnson">Toby Johnson</name><affiliation><nlm:aff id="A56">Clinical Pharmacology and The Genome Center, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kangas, Antti J" sort="Kangas, Antti J" uniqKey="Kangas A" first="Antti J" last="Kangas">Antti J. Kangas</name><affiliation><nlm:aff id="A26">Computational Medicine Research Group, Institute of Clinical Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Kema, Ido P" sort="Kema, Ido P" uniqKey="Kema I" first="Ido P" last="Kema">Ido P. Kema</name><affiliation><nlm:aff id="A57">Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kuhn, Jens P" sort="Kuhn, Jens P" uniqKey="Kuhn J" first="Jens P" last="Kühn">Jens P. Kühn</name><affiliation><nlm:aff id="A58">Institute of Diagnostic Radiology and Neuroradiology, University of Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Lai, Sandra" sort="Lai, Sandra" uniqKey="Lai S" first="Sandra" last="Lai">Sandra Lai</name><affiliation><nlm:aff id="A9">Istituto di Ricerca Genetica e Biomedica del Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy</nlm:aff></affiliation></author><author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><affiliation><nlm:aff id="A49">CEA-IG Centre National de Genotypage, Evry Cedex, France</nlm:aff></affiliation><affiliation><nlm:aff id="A59">Fondation Jean Dausset Ceph, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Lerch, Markus M" sort="Lerch, Markus M" uniqKey="Lerch M" first="Markus M" last="Lerch">Markus M. Lerch</name><affiliation><nlm:aff id="A60">Department of Medicine A, University Medicine Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Li, Yun" sort="Li, Yun" uniqKey="Li Y" first="Yun" last="Li">Yun Li</name><affiliation><nlm:aff id="A61">Department of Genetics, Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina, USA</nlm:aff></affiliation></author><author><name sortKey="Liang, T Jake" sort="Liang, T Jake" uniqKey="Liang T" first="T Jake" last="Liang">T Jake Liang</name><affiliation><nlm:aff id="A62">Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Lin, Jing Ping" sort="Lin, Jing Ping" uniqKey="Lin J" first="Jing-Ping" last="Lin">Jing-Ping Lin</name><affiliation><nlm:aff id="A63">Office of Biostatistics Research, Division of Cardiovascular Sciences, National Heart, Lung and Blood Institute (NHLBI), NIH, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Loos, Ruth J F" sort="Loos, Ruth J F" uniqKey="Loos R" first="Ruth J F" last="Loos">Ruth J F. Loos</name><affiliation><nlm:aff id="A23">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge UK</nlm:aff></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name><affiliation><nlm:aff id="A64">Queensland Institute of Medical Research, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Moffatt, Miriam F" sort="Moffatt, Miriam F" uniqKey="Moffatt M" first="Miriam F" last="Moffatt">Miriam F. Moffatt</name><affiliation><nlm:aff id="A36">National Heart and Lung Institute, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W" last="Montgomery">Grant W. Montgomery</name><affiliation><nlm:aff id="A64">Queensland Institute of Medical Research, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Munroe, Patricia B" sort="Munroe, Patricia B" uniqKey="Munroe P" first="Patricia B" last="Munroe">Patricia B. Munroe</name><affiliation><nlm:aff id="A56">Clinical Pharmacology and The Genome Center, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Musunuru, Kiran" sort="Musunuru, Kiran" uniqKey="Musunuru K" first="Kiran" last="Musunuru">Kiran Musunuru</name><affiliation><nlm:aff id="A31">Boston University School of Medicine, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A65">Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A68">Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Nakamura, Yusuke" sort="Nakamura, Yusuke" uniqKey="Nakamura Y" first="Yusuke" last="Nakamura">Yusuke Nakamura</name><affiliation><nlm:aff id="A17">Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="O Onnell, Christopher J" sort="O Onnell, Christopher J" uniqKey="O Onnell C" first="Christopher J" last="O Onnell">Christopher J. O Onnell</name><affiliation><nlm:aff id="A69">NHLBI Framingham Heart Study, Framingham, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Olafsson, Isleifur" sort="Olafsson, Isleifur" uniqKey="Olafsson I" first="Isleifur" last="Olafsson">Isleifur Olafsson</name><affiliation><nlm:aff id="A70">Department of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Penninx, Brenda W" sort="Penninx, Brenda W" uniqKey="Penninx B" first="Brenda W" last="Penninx">Brenda W. Penninx</name><affiliation><nlm:aff id="A71">Department of Psychiatry and EMGO Institute for Health and Care Research, VUA Medical Centre, Amsterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A72">Department of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A73">Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name><affiliation><nlm:aff id="A48">Institute of Clinical Medicine, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A74">Department of Lifecourse and Services, National Institute for Health and Welfare, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Prins, Bram P" sort="Prins, Bram P" uniqKey="Prins B" first="Bram P" last="Prins">Bram P. Prins</name><affiliation><nlm:aff id="A18">Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation><nlm:aff id="A19">Wellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Puls, Ralf" sort="Puls, Ralf" uniqKey="Puls R" first="Ralf" last="Puls">Ralf Puls</name><affiliation><nlm:aff id="A58">Institute of Diagnostic Radiology and Neuroradiology, University of Greifswald, Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Ruokonen, Aimo" sort="Ruokonen, Aimo" uniqKey="Ruokonen A" first="Aimo" last="Ruokonen">Aimo Ruokonen</name><affiliation><nlm:aff id="A75">Institute of Diagnostics, Clinical Chemistry, University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Savolainen, Markku J" sort="Savolainen, Markku J" uniqKey="Savolainen M" first="Markku J" last="Savolainen">Markku J. Savolainen</name><affiliation><nlm:aff id="A26">Computational Medicine Research Group, Institute of Clinical Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A76">Department of Internal Medicine and Biocenter Oulu, Clinical Research Center, University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Schlessinger, David" sort="Schlessinger, David" uniqKey="Schlessinger D" first="David" last="Schlessinger">David Schlessinger</name><affiliation><nlm:aff id="A77">Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Schouten, Jeoffrey N L" sort="Schouten, Jeoffrey N L" uniqKey="Schouten J" first="Jeoffrey N L" last="Schouten">Jeoffrey N L. Schouten</name><affiliation><nlm:aff id="A55">Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Seedorf, Udo" sort="Seedorf, Udo" uniqKey="Seedorf U" first="Udo" last="Seedorf">Udo Seedorf</name><affiliation><nlm:aff id="A78">Gesellschaft für Arterioskleroseforschung, Leibniz-Institut für Arterioskleroseforschung an der Universität Münster, Münster, Germany</nlm:aff></affiliation></author><author><name sortKey="Sen Chowdhry, Srijita" sort="Sen Chowdhry, Srijita" uniqKey="Sen Chowdhry S" first="Srijita" last="Sen-Chowdhry">Srijita Sen-Chowdhry</name><affiliation><nlm:aff id="A1">Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK</nlm:aff></affiliation></author><author><name sortKey="Siminovitch, Katherine A" sort="Siminovitch, Katherine A" uniqKey="Siminovitch K" first="Katherine A" last="Siminovitch">Katherine A. Siminovitch</name><affiliation><nlm:aff id="A50">Department of Medicine, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A79">Department of Immunology, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A80">Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A81">Mount Sinai Hospital Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A82">Toronto General Research Institute, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Smit, Johannes H" sort="Smit, Johannes H" uniqKey="Smit J" first="Johannes H" last="Smit">Johannes H. Smit</name><affiliation><nlm:aff id="A71">Department of Psychiatry and EMGO Institute for Health and Care Research, VUA Medical Centre, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Spector, Timothy D" sort="Spector, Timothy D" uniqKey="Spector T" first="Timothy D" last="Spector">Timothy D. Spector</name><affiliation><nlm:aff id="A83">Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Tan, Wenting" sort="Tan, Wenting" uniqKey="Tan W" first="Wenting" last="Tan">Wenting Tan</name><affiliation><nlm:aff id="A13">Institute of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing, China</nlm:aff></affiliation></author><author><name sortKey="Teslovich, Tanya M" sort="Teslovich, Tanya M" uniqKey="Teslovich T" first="Tanya M" last="Teslovich">Tanya M. Teslovich</name><affiliation><nlm:aff id="A84">Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA</nlm:aff></affiliation></author><author><name sortKey="Tukiainen, Taru" sort="Tukiainen, Taru" uniqKey="Tukiainen T" first="Taru" last="Tukiainen">Taru Tukiainen</name><affiliation><nlm:aff id="A1">Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A26">Computational Medicine Research Group, Institute of Clinical Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G" last="Uitterlinden">Andre G. Uitterlinden</name><affiliation><nlm:aff id="A10">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Netherlands Genomics Initiative-Sponsored Netherlands Consortium for Health Aging, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A85">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Der Klauw, Melanie M" sort="Van Der Klauw, Melanie M" uniqKey="Van Der Klauw M" first="Melanie M" last="Van Der Klauw">Melanie M. Van Der Klauw</name><affiliation><nlm:aff id="A86">Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A87">LifeLines Cohort Study and Biobank, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Vasan, Ramachandran S" sort="Vasan, Ramachandran S" uniqKey="Vasan R" first="Ramachandran S" last="Vasan">Ramachandran S. Vasan</name><affiliation><nlm:aff id="A88">Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A89">Cardiology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Wallace, Chris" sort="Wallace, Chris" uniqKey="Wallace C" first="Chris" last="Wallace">Chris Wallace</name><affiliation><nlm:aff id="A33">The Diabetes Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Wallaschofski, Henri" sort="Wallaschofski, Henri" uniqKey="Wallaschofski H" first="Henri" last="Wallaschofski">Henri Wallaschofski</name><affiliation><nlm:aff id="A43">Institute of Clinical Chemistry and Laboratory Medicine, University of Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H-Erich" last="Wichmann">H-Erich Wichmann</name><affiliation><nlm:aff id="A37">Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A90">Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A91">Klinikum Grosshadern, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name><affiliation><nlm:aff id="A16">Department of Biological Psychology, VU University Amsterdam (VUA), Amsterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A92">EMGO<sup>+</sup>Institute, VUA Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wurtz, Peter" sort="Wurtz, Peter" uniqKey="Wurtz P" first="Peter" last="Würtz">Peter Würtz</name><affiliation><nlm:aff id="A1">Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A26">Computational Medicine Research Group, Institute of Clinical Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Xu, Chun" sort="Xu, Chun" uniqKey="Xu C" first="Chun" last="Xu">Chun Xu</name><affiliation><nlm:aff id="A93">Samuel Lunenfeld and Toronto General Research Institutes, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Yerges Armstrong, Laura M" sort="Yerges Armstrong, Laura M" uniqKey="Yerges Armstrong L" first="Laura M" last="Yerges-Armstrong">Laura M. Yerges-Armstrong</name><affiliation><nlm:aff id="A94">Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Abecasis, Goncalo R" sort="Abecasis, Goncalo R" uniqKey="Abecasis G" first="Goncalo R" last="Abecasis">Goncalo R. Abecasis</name><affiliation><nlm:aff id="A84">Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA</nlm:aff></affiliation></author><author><name sortKey="Ahmadi, Kourosh R" sort="Ahmadi, Kourosh R" uniqKey="Ahmadi K" first="Kourosh R" last="Ahmadi">Kourosh R. Ahmadi</name><affiliation><nlm:aff id="A83">Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I" last="Boomsma">Dorret I. Boomsma</name><affiliation><nlm:aff id="A16">Department of Biological Psychology, VU University Amsterdam (VUA), Amsterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A92">EMGO<sup>+</sup>Institute, VUA Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Caulfield, Mark" sort="Caulfield, Mark" uniqKey="Caulfield M" first="Mark" last="Caulfield">Mark Caulfield</name><affiliation><nlm:aff id="A56">Clinical Pharmacology and The Genome Center, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Cookson, William O" sort="Cookson, William O" uniqKey="Cookson W" first="William O" last="Cookson">William O. Cookson</name><affiliation><nlm:aff id="A36">National Heart and Lung Institute, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name><affiliation><nlm:aff id="A10">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Netherlands Genomics Initiative-Sponsored Netherlands Consortium for Health Aging, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A95">Center for Medical Systems Biology, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation><nlm:aff id="A96">Genomics of Common Diseases, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="Matsuda, Koichi" sort="Matsuda, Koichi" uniqKey="Matsuda K" first="Koichi" last="Matsuda">Koichi Matsuda</name><affiliation><nlm:aff id="A17">Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I" last="Mccarthy">Mark I. Mccarthy</name><affiliation><nlm:aff id="A19">Wellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A97">Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Meisinger, Christa" sort="Meisinger, Christa" uniqKey="Meisinger C" first="Christa" last="Meisinger">Christa Meisinger</name><affiliation><nlm:aff id="A98">Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Mooser, Vincent" sort="Mooser, Vincent" uniqKey="Mooser V" first="Vincent" last="Mooser">Vincent Mooser</name><affiliation><nlm:aff id="A30">Genetics, GlaxoSmithKline, King of Prussia, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Pietil Inen, Kirsi H" sort="Pietil Inen, Kirsi H" uniqKey="Pietil Inen K" first="Kirsi H" last="Pietil Inen">Kirsi H. Pietil Inen</name><affiliation><nlm:aff id="A99">Obesity Research Unit, Department of Medicine, Division of Internal Medicine, Helsinki University Hospital, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A100">The Institute for Molecular Medicine FIMM, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A101">Hjelt Institute, Department of Public Health, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Schumann, Gunter" sort="Schumann, Gunter" uniqKey="Schumann G" first="Gunter" last="Schumann">Gunter Schumann</name><affiliation><nlm:aff id="A102">MRC-Social Genetic Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, King’s College, London, UK</nlm:aff></affiliation></author><author><name sortKey="Snieder, Harold" sort="Snieder, Harold" uniqKey="Snieder H" first="Harold" last="Snieder">Harold Snieder</name><affiliation><nlm:aff id="A18">Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Sternberg, Michael J E" sort="Sternberg, Michael J E" uniqKey="Sternberg M" first="Michael J E" last="Sternberg">Michael J E. Sternberg</name><affiliation><nlm:aff id="A6">Structural Bioinformatics Group, Division of Molecular Biosciences, Imperial College London, South Kensington, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A87">LifeLines Cohort Study and Biobank, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Stolk, Ronald P" sort="Stolk, Ronald P" uniqKey="Stolk R" first="Ronald P" last="Stolk">Ronald P. Stolk</name><affiliation><nlm:aff id="A103">Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Thomas, Howard C" sort="Thomas, Howard C" uniqKey="Thomas H" first="Howard C" last="Thomas">Howard C. Thomas</name><affiliation><nlm:aff id="A2">Imperial College Healthcare National Health Service (NHS) Trust, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A104">Faculty of Medicine, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation><nlm:aff id="A8">deCODE genetics, Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A105">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Uda, Manuela" sort="Uda, Manuela" uniqKey="Uda M" first="Manuela" last="Uda">Manuela Uda</name><affiliation><nlm:aff id="A9">Istituto di Ricerca Genetica e Biomedica del Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy</nlm:aff></affiliation></author><author><name sortKey="Waeber, Gerard" sort="Waeber, Gerard" uniqKey="Waeber G" first="Gérard" last="Waeber">Gérard Waeber</name><affiliation><nlm:aff id="A106">Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J" last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:aff id="A23">Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge UK</nlm:aff></affiliation></author><author><name sortKey="Waterworth, Dawn M" sort="Waterworth, Dawn M" uniqKey="Waterworth D" first="Dawn M" last="Waterworth">Dawn M. Waterworth</name><affiliation><nlm:aff id="A30">Genetics, GlaxoSmithKline, King of Prussia, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Watkins, Hugh" sort="Watkins, Hugh" uniqKey="Watkins H" first="Hugh" last="Watkins">Hugh Watkins</name><affiliation><nlm:aff id="A25">Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A42">Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Whitfield, John B" sort="Whitfield, John B" uniqKey="Whitfield J" first="John B" last="Whitfield">John B. Whitfield</name><affiliation><nlm:aff id="A64">Queensland Institute of Medical Research, Brisbane, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Witteman, Jacqueline C M" sort="Witteman, Jacqueline C M" uniqKey="Witteman J" first="Jacqueline C M" last="Witteman">Jacqueline C M. Witteman</name><affiliation><nlm:aff id="A10">Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Netherlands Genomics Initiative-Sponsored Netherlands Consortium for Health Aging, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wolffenbuttel, Bruce H R" sort="Wolffenbuttel, Bruce H R" uniqKey="Wolffenbuttel B" first="Bruce H R" last="Wolffenbuttel">Bruce H R. Wolffenbuttel</name><affiliation><nlm:aff id="A86">Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A87">LifeLines Cohort Study and Biobank, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Fox, Caroline S" sort="Fox, Caroline S" uniqKey="Fox C" first="Caroline S" last="Fox">Caroline S. Fox</name><affiliation><nlm:aff id="A69">NHLBI Framingham Heart Study, Framingham, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A107">Division of Endocrinology, Hypertension, and Metabolism, Brigham and Women’s Hospital, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Ala Korpela, Mika" sort="Ala Korpela, Mika" uniqKey="Ala Korpela M" first="Mika" last="Ala-Korpela">Mika Ala-Korpela</name><affiliation><nlm:aff id="A26">Computational Medicine Research Group, Institute of Clinical Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Nuclear Magnetic Resonance (NMR) Metabonomics Laboratory, Department of Biosciences, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A76">Department of Internal Medicine and Biocenter Oulu, Clinical Research Center, University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation><nlm:aff id="A8">deCODE genetics, Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A105">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation><nlm:aff id="A106">Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name><affiliation><nlm:aff id="A12">Institute for Community Medicine, University of Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Schadt, Eric E" sort="Schadt, Eric E" uniqKey="Schadt E" first="Eric E" last="Schadt">Eric E. Schadt</name><affiliation><nlm:aff id="A108">Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Scott, James" sort="Scott, James" uniqKey="Scott J" first="James" last="Scott">James Scott</name><affiliation><nlm:aff id="A4">National Heart and Lung Institute, Imperial College London, Hammersmith Hospital, London, UK</nlm:aff></affiliation></author><author><name sortKey="J Rvelin, Marjo Riitta" sort="J Rvelin, Marjo Riitta" uniqKey="J Rvelin M" first="Marjo-Riitta" last="J Rvelin">Marjo-Riitta J Rvelin</name><affiliation><nlm:aff id="A1">Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A74">Department of Lifecourse and Services, National Institute for Health and Welfare, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A109">Institute of Health Sciences, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A110">Biocenter Oulu, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A111">MRC–Health Protection Agency (HPA) Centre for Environment and Health, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation><nlm:aff id="A1">Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A111">MRC–Health Protection Agency (HPA) Centre for Environment and Health, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kooner, Jaspal S" sort="Kooner, Jaspal S" uniqKey="Kooner J" first="Jaspal S" last="Kooner">Jaspal S. Kooner</name><affiliation><nlm:aff id="A2">Imperial College Healthcare National Health Service (NHS) Trust, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Ealing Hospital NHS Trust, Middlesex, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A4">National Heart and Lung Institute, Imperial College London, Hammersmith Hospital, London, UK</nlm:aff></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="ISSN">1061-4036</idno><idno type="eISSN">1546-1718</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci associated with concentrations of liver enzymes in plasma, of which 32 are new associations (<italic>P</italic> = 10<sup>−8</sup> to <italic>P</italic> = 10<sup>−190</sup>). We used functional genomic approaches including metabonomic profiling and gene expression analyses to identify probable candidate genes at these regions. We identified 69 candidate genes, including genes involved in biliary transport (<italic>ATP8B1</italic> and <italic>ABCB11</italic>), glucose, carbohydrate and lipid metabolism (<italic>FADS1</italic>, <italic>FADS2</italic>, <italic>GCKR</italic>, JMJD1C, HNF1A, MLXIPL, PNPLA3, PPP1R3B, SLC2A2 and <italic>TRIB1</italic>), glycoprotein biosynthesis and cell surface glycobiology (<italic>ABO</italic>, <italic>ASGR1</italic>, <italic>FUT2</italic>, <italic>GPLD1</italic> and <italic>ST3GAL4</italic>), inflammation and immunity (<italic>CD276</italic>, <italic>CDH6</italic>, <italic>GCKR</italic>, <italic>HNF1A</italic>, <italic>HPR</italic>, <italic>ITGA1</italic>, <italic>RORA</italic> and <italic>STAT4</italic>) and glutathione metabolism (<italic>GSTT1</italic>, <italic>GSTT2</italic> and <italic>GGT</italic>), as well as several genes of uncertain or unknown function (including <italic>ABHD12</italic>, <italic>EFHD1</italic>, <italic>EFNA1</italic>, <italic>EPHA2</italic>, <italic>MICAL3</italic> and <italic>ZNF827</italic>). Our results provide new insight into genetic mechanisms and pathways influencing markers of liver function.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9216904</journal-id><journal-id journal-id-type="pubmed-jr-id">2419</journal-id><journal-id journal-id-type="nlm-ta">Nat Genet</journal-id><journal-id journal-id-type="iso-abbrev">Nat. Genet.</journal-id><journal-title-group><journal-title>Nature genetics</journal-title></journal-title-group><issn pub-type="ppub">1061-4036</issn><issn pub-type="epub">1546-1718</issn></journal-meta><article-meta><article-id pub-id-type="pmid">22001757</article-id><article-id pub-id-type="pmc">3482372</article-id><article-id pub-id-type="doi">10.1038/ng.970</article-id><article-id pub-id-type="manuscript">NIHMS411128</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Chambers</surname><given-names>John C</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref><xref rid="FN3" ref-type="author-notes">113</xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Weihua</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A3">3</xref><xref rid="FN3" ref-type="author-notes">113</xref></contrib><contrib contrib-type="author"><name><surname>Sehmi</surname><given-names>Joban</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref><xref rid="FN3" ref-type="author-notes">113</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Xinzhong</given-names></name><xref ref-type="aff" rid="A5">5</xref><xref rid="FN3" ref-type="author-notes">113</xref></contrib><contrib contrib-type="author"><name><surname>Wass</surname><given-names>Mark N</given-names></name><xref ref-type="aff" rid="A6">6</xref><xref rid="FN3" ref-type="author-notes">113</xref></contrib><contrib contrib-type="author"><name><surname>Van der Harst</surname><given-names>Pim</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref rid="FN3" ref-type="author-notes">113</xref></contrib><contrib contrib-type="author"><name><surname>Holm</surname><given-names>Hilma</given-names></name><xref ref-type="aff" rid="A8">8</xref><xref rid="FN3" ref-type="author-notes">113</xref></contrib><contrib contrib-type="author"><name><surname>Sanna</surname><given-names>Serena</given-names></name><xref ref-type="aff" rid="A9">9</xref><xref rid="FN3" ref-type="author-notes">113</xref></contrib><contrib contrib-type="author"><name><surname>Kavousi</surname><given-names>Maryam</given-names></name><xref ref-type="aff" rid="A10">10</xref><xref ref-type="aff" rid="A11">11</xref><xref rid="FN3" ref-type="author-notes">113</xref></contrib><contrib contrib-type="author"><name><surname>Baumeister</surname><given-names>Sebastian E</given-names></name><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Coin</surname><given-names>Lachlan J</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Deng</surname><given-names>Guohong</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Gieger</surname><given-names>Christian</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Heard-Costa</surname><given-names>Nancy L</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Hottenga</surname><given-names>Jouke-Jan</given-names></name><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Kühnel</surname><given-names>Brigitte</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Kumar</surname><given-names>Vinod</given-names></name><xref ref-type="aff" rid="A17">17</xref></contrib><contrib contrib-type="author"><name><surname>Lagou</surname><given-names>Vasiliki</given-names></name><xref ref-type="aff" rid="A18">18</xref><xref ref-type="aff" rid="A19">19</xref><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Liang</surname><given-names>Liming</given-names></name><xref ref-type="aff" rid="A21">21</xref><xref ref-type="aff" rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>Luan</surname><given-names>Jian’an</given-names></name><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Vidal</surname><given-names>Pedro Marques</given-names></name><xref ref-type="aff" rid="A24">24</xref></contrib><contrib contrib-type="author"><name><surname>Leach</surname><given-names>Irene Mateo</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>O’Reilly</surname><given-names>Paul F</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Peden</surname><given-names>John F</given-names></name><xref ref-type="aff" rid="A25">25</xref></contrib><contrib contrib-type="author"><name><surname>Rahmioglu</surname><given-names>Nilufer</given-names></name><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Soininen</surname><given-names>Pasi</given-names></name><xref ref-type="aff" rid="A26">26</xref><xref ref-type="aff" rid="A27">27</xref></contrib><contrib contrib-type="author"><name><surname>Speliotes</surname><given-names>Elizabeth K</given-names></name><xref ref-type="aff" rid="A28">28</xref><xref ref-type="aff" rid="A29">29</xref></contrib><contrib contrib-type="author"><name><surname>Yuan</surname><given-names>Xin</given-names></name><xref ref-type="aff" rid="A30">30</xref></contrib><contrib contrib-type="author"><name><surname>Thorleifsson</surname><given-names>Gudmar</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Alizadeh</surname><given-names>Behrooz Z</given-names></name><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Atwood</surname><given-names>Larry D</given-names></name><xref ref-type="aff" rid="A31">31</xref></contrib><contrib contrib-type="author"><name><surname>Borecki</surname><given-names>Ingrid B</given-names></name><xref ref-type="aff" rid="A32">32</xref></contrib><contrib contrib-type="author"><name><surname>Brown</surname><given-names>Morris J</given-names></name><xref ref-type="aff" rid="A33">33</xref></contrib><contrib contrib-type="author"><name><surname>Charoen</surname><given-names>Pimphen</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A34">34</xref></contrib><contrib contrib-type="author"><name><surname>Cucca</surname><given-names>Francesco</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Das</surname><given-names>Debashish</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>de Geus</surname><given-names>Eco J C</given-names></name><xref ref-type="aff" rid="A16">16</xref><xref ref-type="aff" rid="A35">35</xref></contrib><contrib contrib-type="author"><name><surname>Dixon</surname><given-names>Anna L</given-names></name><xref ref-type="aff" rid="A36">36</xref></contrib><contrib contrib-type="author"><name><surname>Döring</surname><given-names>Angela</given-names></name><xref ref-type="aff" rid="A37">37</xref></contrib><contrib contrib-type="author"><name><surname>Ehret</surname><given-names>Georg</given-names></name><xref ref-type="aff" rid="A38">38</xref><xref ref-type="aff" rid="A39">39</xref><xref ref-type="aff" rid="A40">40</xref></contrib><contrib contrib-type="author"><name><surname>Eyjolfsson</surname><given-names>Gudmundur I</given-names></name><xref ref-type="aff" rid="A41">41</xref></contrib><contrib contrib-type="author"><name><surname>Farrall</surname><given-names>Martin</given-names></name><xref ref-type="aff" rid="A25">25</xref><xref ref-type="aff" rid="A42">42</xref></contrib><contrib contrib-type="author"><name><surname>Forouhi</surname><given-names>Nita G</given-names></name><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Friedrich</surname><given-names>Nele</given-names></name><xref ref-type="aff" rid="A43">43</xref></contrib><contrib contrib-type="author"><name><surname>Goessling</surname><given-names>Wolfram</given-names></name><xref ref-type="aff" rid="A44">44</xref><xref ref-type="aff" rid="A45">45</xref><xref ref-type="aff" rid="A46">46</xref></contrib><contrib contrib-type="author"><name><surname>Gudbjartsson</surname><given-names>Daniel F</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Harris</surname><given-names>Tamara B</given-names></name><xref ref-type="aff" rid="A47">47</xref></contrib><contrib contrib-type="author"><name><surname>Hartikainen</surname><given-names>Anna-Liisa</given-names></name><xref ref-type="aff" rid="A48">48</xref></contrib><contrib contrib-type="author"><name><surname>Heath</surname><given-names>Simon</given-names></name><xref ref-type="aff" rid="A49">49</xref></contrib><contrib contrib-type="author"><name><surname>Hirschfield</surname><given-names>Gideon M</given-names></name><xref ref-type="aff" rid="A50">50</xref><xref ref-type="aff" rid="A51">51</xref><xref ref-type="aff" rid="A52">52</xref></contrib><contrib contrib-type="author"><name><surname>Hofman</surname><given-names>Albert</given-names></name><xref ref-type="aff" rid="A10">10</xref><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Homuth</surname><given-names>Georg</given-names></name><xref ref-type="aff" rid="A53">53</xref></contrib><contrib contrib-type="author"><name><surname>Hyppönen</surname><given-names>Elina</given-names></name><xref ref-type="aff" rid="A54">54</xref></contrib><contrib contrib-type="author"><name><surname>Janssen</surname><given-names>Harry L A</given-names></name><xref ref-type="aff" rid="A10">10</xref><xref ref-type="aff" rid="A55">55</xref></contrib><contrib contrib-type="author"><name><surname>Johnson</surname><given-names>Toby</given-names></name><xref ref-type="aff" rid="A56">56</xref></contrib><contrib contrib-type="author"><name><surname>Kangas</surname><given-names>Antti J</given-names></name><xref ref-type="aff" rid="A26">26</xref></contrib><contrib contrib-type="author"><name><surname>Kema</surname><given-names>Ido P</given-names></name><xref ref-type="aff" rid="A57">57</xref></contrib><contrib contrib-type="author"><name><surname>Kühn</surname><given-names>Jens P</given-names></name><xref ref-type="aff" rid="A58">58</xref></contrib><contrib contrib-type="author"><name><surname>Lai</surname><given-names>Sandra</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Lathrop</surname><given-names>Mark</given-names></name><xref ref-type="aff" rid="A49">49</xref><xref ref-type="aff" rid="A59">59</xref></contrib><contrib contrib-type="author"><name><surname>Lerch</surname><given-names>Markus M</given-names></name><xref ref-type="aff" rid="A60">60</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Yun</given-names></name><xref ref-type="aff" rid="A61">61</xref></contrib><contrib contrib-type="author"><name><surname>Liang</surname><given-names>T Jake</given-names></name><xref ref-type="aff" rid="A62">62</xref></contrib><contrib contrib-type="author"><name><surname>Lin</surname><given-names>Jing-Ping</given-names></name><xref ref-type="aff" rid="A63">63</xref></contrib><contrib contrib-type="author"><name><surname>Loos</surname><given-names>Ruth J F</given-names></name><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Martin</surname><given-names>Nicholas G</given-names></name><xref ref-type="aff" rid="A64">64</xref></contrib><contrib contrib-type="author"><name><surname>Moffatt</surname><given-names>Miriam F</given-names></name><xref ref-type="aff" rid="A36">36</xref></contrib><contrib contrib-type="author"><name><surname>Montgomery</surname><given-names>Grant W</given-names></name><xref ref-type="aff" rid="A64">64</xref></contrib><contrib contrib-type="author"><name><surname>Munroe</surname><given-names>Patricia B</given-names></name><xref ref-type="aff" rid="A56">56</xref></contrib><contrib contrib-type="author"><name><surname>Musunuru</surname><given-names>Kiran</given-names></name><xref ref-type="aff" rid="A31">31</xref><xref ref-type="aff" rid="A65">65</xref><xref ref-type="aff" rid="A68">68</xref></contrib><contrib contrib-type="author"><name><surname>Nakamura</surname><given-names>Yusuke</given-names></name><xref ref-type="aff" rid="A17">17</xref></contrib><contrib contrib-type="author"><name><surname>O’Donnell</surname><given-names>Christopher J</given-names></name><xref ref-type="aff" rid="A69">69</xref></contrib><contrib contrib-type="author"><name><surname>Olafsson</surname><given-names>Isleifur</given-names></name><xref ref-type="aff" rid="A70">70</xref></contrib><contrib contrib-type="author"><name><surname>Penninx</surname><given-names>Brenda W</given-names></name><xref ref-type="aff" rid="A71">71</xref><xref ref-type="aff" rid="A72">72</xref><xref ref-type="aff" rid="A73">73</xref></contrib><contrib contrib-type="author"><name><surname>Pouta</surname><given-names>Anneli</given-names></name><xref ref-type="aff" rid="A48">48</xref><xref ref-type="aff" rid="A74">74</xref></contrib><contrib contrib-type="author"><name><surname>Prins</surname><given-names>Bram P</given-names></name><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Prokopenko</surname><given-names>Inga</given-names></name><xref ref-type="aff" rid="A19">19</xref><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Puls</surname><given-names>Ralf</given-names></name><xref ref-type="aff" rid="A58">58</xref></contrib><contrib contrib-type="author"><name><surname>Ruokonen</surname><given-names>Aimo</given-names></name><xref ref-type="aff" rid="A75">75</xref></contrib><contrib contrib-type="author"><name><surname>Savolainen</surname><given-names>Markku J</given-names></name><xref ref-type="aff" rid="A26">26</xref><xref ref-type="aff" rid="A76">76</xref></contrib><contrib contrib-type="author"><name><surname>Schlessinger</surname><given-names>David</given-names></name><xref ref-type="aff" rid="A77">77</xref></contrib><contrib contrib-type="author"><name><surname>Schouten</surname><given-names>Jeoffrey N L</given-names></name><xref ref-type="aff" rid="A55">55</xref></contrib><contrib contrib-type="author"><name><surname>Seedorf</surname><given-names>Udo</given-names></name><xref ref-type="aff" rid="A78">78</xref></contrib><contrib contrib-type="author"><name><surname>Sen-Chowdhry</surname><given-names>Srijita</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Siminovitch</surname><given-names>Katherine A</given-names></name><xref ref-type="aff" rid="A50">50</xref><xref ref-type="aff" rid="A79">79</xref><xref ref-type="aff" rid="A80">80</xref><xref ref-type="aff" rid="A81">81</xref><xref ref-type="aff" rid="A82">82</xref></contrib><contrib contrib-type="author"><name><surname>Smit</surname><given-names>Johannes H</given-names></name><xref ref-type="aff" rid="A71">71</xref></contrib><contrib contrib-type="author"><name><surname>Spector</surname><given-names>Timothy D</given-names></name><xref ref-type="aff" rid="A83">83</xref></contrib><contrib contrib-type="author"><name><surname>Tan</surname><given-names>Wenting</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Teslovich</surname><given-names>Tanya M</given-names></name><xref ref-type="aff" rid="A84">84</xref></contrib><contrib contrib-type="author"><name><surname>Tukiainen</surname><given-names>Taru</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A26">26</xref></contrib><contrib contrib-type="author"><name><surname>Uitterlinden</surname><given-names>Andre G</given-names></name><xref ref-type="aff" rid="A10">10</xref><xref ref-type="aff" rid="A11">11</xref><xref ref-type="aff" rid="A85">85</xref></contrib><contrib contrib-type="author"><name><surname>Van der Klauw</surname><given-names>Melanie M</given-names></name><xref ref-type="aff" rid="A86">86</xref><xref ref-type="aff" rid="A87">87</xref></contrib><contrib contrib-type="author"><name><surname>Vasan</surname><given-names>Ramachandran S</given-names></name><xref ref-type="aff" rid="A88">88</xref><xref ref-type="aff" rid="A89">89</xref></contrib><contrib contrib-type="author"><name><surname>Wallace</surname><given-names>Chris</given-names></name><xref ref-type="aff" rid="A33">33</xref></contrib><contrib contrib-type="author"><name><surname>Wallaschofski</surname><given-names>Henri</given-names></name><xref ref-type="aff" rid="A43">43</xref></contrib><contrib contrib-type="author"><name><surname>Wichmann</surname><given-names>H-Erich</given-names></name><xref ref-type="aff" rid="A37">37</xref><xref ref-type="aff" rid="A90">90</xref><xref ref-type="aff" rid="A91">91</xref></contrib><contrib contrib-type="author"><name><surname>Willemsen</surname><given-names>Gonneke</given-names></name><xref ref-type="aff" rid="A16">16</xref><xref ref-type="aff" rid="A92">92</xref></contrib><contrib contrib-type="author"><name><surname>Würtz</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A26">26</xref></contrib><contrib contrib-type="author"><name><surname>Xu</surname><given-names>Chun</given-names></name><xref ref-type="aff" rid="A93">93</xref></contrib><contrib contrib-type="author"><name><surname>Yerges-Armstrong</surname><given-names>Laura M</given-names></name><xref ref-type="aff" rid="A94">94</xref></contrib><contrib contrib-type="author"><collab>Alcohol Genome-wide Association (AlcGen) Consortium</collab><xref rid="FN2" ref-type="author-notes">95</xref></contrib><contrib contrib-type="author"><collab>Diabetes Genetics Replication and Meta-analyses (DIAGRAM+) Study</collab><xref rid="FN2" ref-type="author-notes">95</xref></contrib><contrib contrib-type="author"><collab>Genetic Investigation of Anthropometric Traits (GIANT) Consortium</collab><xref rid="FN2" ref-type="author-notes">95</xref></contrib><contrib contrib-type="author"><collab>Global Lipids Genetics Consortium</collab><xref rid="FN2" ref-type="author-notes">95</xref></contrib><contrib contrib-type="author"><collab>Genetics of Liver Disease (GOLD) Consortium</collab><xref rid="FN2" ref-type="author-notes">95</xref></contrib><contrib contrib-type="author"><collab>International Consortium for Blood Pressure (ICBP-GWAS)</collab><xref rid="FN2" ref-type="author-notes">95</xref></contrib><contrib contrib-type="author"><collab>Meta-analyses of Glucose and Insulin-Related Traits Consortium (MAGIC)</collab><xref rid="FN2" ref-type="author-notes">95</xref></contrib><contrib contrib-type="author"><name><surname>Abecasis</surname><given-names>Goncalo R</given-names></name><xref ref-type="aff" rid="A84">84</xref></contrib><contrib contrib-type="author"><name><surname>Ahmadi</surname><given-names>Kourosh R</given-names></name><xref ref-type="aff" rid="A83">83</xref></contrib><contrib contrib-type="author"><name><surname>Boomsma</surname><given-names>Dorret I</given-names></name><xref ref-type="aff" rid="A16">16</xref><xref ref-type="aff" rid="A92">92</xref></contrib><contrib contrib-type="author"><name><surname>Caulfield</surname><given-names>Mark</given-names></name><xref ref-type="aff" rid="A56">56</xref></contrib><contrib contrib-type="author"><name><surname>Cookson</surname><given-names>William O</given-names></name><xref ref-type="aff" rid="A36">36</xref></contrib><contrib contrib-type="author"><name><surname>van Duijn</surname><given-names>Cornelia M</given-names></name><xref ref-type="aff" rid="A10">10</xref><xref ref-type="aff" rid="A11">11</xref><xref ref-type="aff" rid="A95">96</xref></contrib><contrib contrib-type="author"><name><surname>Froguel</surname><given-names>Philippe</given-names></name><xref ref-type="aff" rid="A96">97</xref></contrib><contrib contrib-type="author"><name><surname>Matsuda</surname><given-names>Koichi</given-names></name><xref ref-type="aff" rid="A17">17</xref></contrib><contrib contrib-type="author"><name><surname>McCarthy</surname><given-names>Mark I</given-names></name><xref ref-type="aff" rid="A19">19</xref><xref ref-type="aff" rid="A20">20</xref><xref ref-type="aff" rid="A97">98</xref></contrib><contrib contrib-type="author"><name><surname>Meisinger</surname><given-names>Christa</given-names></name><xref ref-type="aff" rid="A98">99</xref></contrib><contrib contrib-type="author"><name><surname>Mooser</surname><given-names>Vincent</given-names></name><xref ref-type="aff" rid="A30">30</xref></contrib><contrib contrib-type="author"><name><surname>Pietiläinen</surname><given-names>Kirsi H</given-names></name><xref ref-type="aff" rid="A99">100</xref><xref ref-type="aff" rid="A100">101</xref><xref ref-type="aff" rid="A101">102</xref></contrib><contrib contrib-type="author"><name><surname>Schumann</surname><given-names>Gunter</given-names></name><xref ref-type="aff" rid="A102">103</xref></contrib><contrib contrib-type="author"><name><surname>Snieder</surname><given-names>Harold</given-names></name><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Sternberg</surname><given-names>Michael J E</given-names></name><xref ref-type="aff" rid="A6">6</xref><xref ref-type="aff" rid="A87">87</xref></contrib><contrib contrib-type="author"><name><surname>Stolk</surname><given-names>Ronald P</given-names></name><xref ref-type="aff" rid="A103">104</xref></contrib><contrib contrib-type="author"><name><surname>Thomas</surname><given-names>Howard C</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A104">105</xref></contrib><contrib contrib-type="author"><name><surname>Thorsteinsdottir</surname><given-names>Unnur</given-names></name><xref ref-type="aff" rid="A8">8</xref><xref ref-type="aff" rid="A105">106</xref></contrib><contrib contrib-type="author"><name><surname>Uda</surname><given-names>Manuela</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Waeber</surname><given-names>Gérard</given-names></name><xref ref-type="aff" rid="A106">107</xref></contrib><contrib contrib-type="author"><name><surname>Wareham</surname><given-names>Nicholas J</given-names></name><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Waterworth</surname><given-names>Dawn M</given-names></name><xref ref-type="aff" rid="A30">30</xref></contrib><contrib contrib-type="author"><name><surname>Watkins</surname><given-names>Hugh</given-names></name><xref ref-type="aff" rid="A25">25</xref><xref ref-type="aff" rid="A42">42</xref></contrib><contrib contrib-type="author"><name><surname>Whitfield</surname><given-names>John B</given-names></name><xref ref-type="aff" rid="A64">64</xref></contrib><contrib contrib-type="author"><name><surname>Witteman</surname><given-names>Jacqueline C M</given-names></name><xref ref-type="aff" rid="A10">10</xref><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Wolffenbuttel</surname><given-names>Bruce H R</given-names></name><xref ref-type="aff" rid="A86">86</xref><xref ref-type="aff" rid="A87">87</xref></contrib><contrib contrib-type="author"><name><surname>Fox</surname><given-names>Caroline S</given-names></name><xref ref-type="aff" rid="A69">69</xref><xref ref-type="aff" rid="A107">108</xref></contrib><contrib contrib-type="author"><name><surname>Ala-Korpela</surname><given-names>Mika</given-names></name><xref ref-type="aff" rid="A26">26</xref><xref ref-type="aff" rid="A27">27</xref><xref ref-type="aff" rid="A76">76</xref><xref rid="FN3" ref-type="author-notes">113</xref></contrib><contrib contrib-type="author"><name><surname>Stefansson</surname><given-names>Kari</given-names></name><xref ref-type="aff" rid="A8">8</xref><xref ref-type="aff" rid="A105">106</xref><xref rid="FN3" ref-type="author-notes">113</xref></contrib><contrib contrib-type="author"><name><surname>Vollenweider</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="A106">107</xref><xref rid="FN3" ref-type="author-notes">113</xref></contrib><contrib contrib-type="author"><name><surname>Völzke</surname><given-names>Henry</given-names></name><xref ref-type="aff" rid="A12">12</xref><xref rid="FN3" ref-type="author-notes">113</xref></contrib><contrib contrib-type="author"><name><surname>Schadt</surname><given-names>Eric E</given-names></name><xref ref-type="aff" rid="A108">109</xref><xref rid="FN3" ref-type="author-notes">113</xref></contrib><contrib contrib-type="author"><name><surname>Scott</surname><given-names>James</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref rid="FN3" ref-type="author-notes">113</xref></contrib><contrib contrib-type="author"><name><surname>Järvelin</surname><given-names>Marjo-Riitta</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A74">74</xref><xref ref-type="aff" rid="A109">110</xref><xref ref-type="aff" rid="A110">111</xref><xref ref-type="aff" rid="A111">112</xref><xref rid="FN3" ref-type="author-notes">113</xref></contrib><contrib contrib-type="author"><name><surname>Elliott</surname><given-names>Paul</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A111">112</xref><xref rid="FN3" ref-type="author-notes">113</xref></contrib><contrib contrib-type="author"><name><surname>Kooner</surname><given-names>Jaspal S</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref><xref rid="FN3" ref-type="author-notes">113</xref></contrib></contrib-group><aff id="A1"><label>1</label>Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK</aff><aff id="A2"><label>2</label>Imperial College Healthcare National Health Service (NHS) Trust, London, UK</aff><aff id="A3"><label>3</label>Ealing Hospital NHS Trust, Middlesex, UK</aff><aff id="A4"><label>4</label>National Heart and Lung Institute, Imperial College London, Hammersmith Hospital, London, UK</aff><aff id="A5"><label>5</label>Institute of Clinical Science, Imperial College London, Royal Brompton Hospital, London, UK</aff><aff id="A6"><label>6</label>Structural Bioinformatics Group, Division of Molecular Biosciences, Imperial College London, South Kensington, London, UK</aff><aff id="A7"><label>7</label>Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands</aff><aff id="A8"><label>8</label>deCODE genetics, Reykjavik, Iceland</aff><aff id="A9"><label>9</label>Istituto di Ricerca Genetica e Biomedica del Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy</aff><aff id="A10"><label>10</label>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands</aff><aff id="A11"><label>11</label>Netherlands Genomics Initiative-Sponsored Netherlands Consortium for Health Aging, Rotterdam, The Netherlands</aff><aff id="A12"><label>12</label>Institute for Community Medicine, University of Greifswald, Germany</aff><aff id="A13"><label>13</label>Institute of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing, China</aff><aff id="A14"><label>14</label>Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</aff><aff id="A15"><label>15</label>Department of Neurology, Boston University School of Medicine, Boston Massachusetts, USA</aff><aff id="A16"><label>16</label>Department of Biological Psychology, VU University Amsterdam (VUA), Amsterdam, The Netherlands</aff><aff id="A17"><label>17</label>Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan</aff><aff id="A18"><label>18</label>Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</aff><aff id="A19"><label>19</label>Wellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK</aff><aff id="A20"><label>20</label>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK</aff><aff id="A21"><label>21</label>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</aff><aff id="A22"><label>22</label>Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA</aff><aff id="A23"><label>23</label>Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge UK</aff><aff id="A24"><label>24</label>Institute of Social and Preventive Medicine (IUMSP), University Hospital and University of Lausanne, Lausanne, Switzerland</aff><aff id="A25"><label>25</label>Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK</aff><aff id="A26"><label>26</label>Computational Medicine Research Group, Institute of Clinical Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland</aff><aff id="A27"><label>27</label>Nuclear Magnetic Resonance (NMR) Metabonomics Laboratory, Department of Biosciences, University of Eastern Finland, Kuopio, Finland</aff><aff id="A28"><label>28</label>Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA</aff><aff id="A29"><label>29</label>Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA</aff><aff id="A30"><label>30</label>Genetics, GlaxoSmithKline, King of Prussia, Pennsylvania, USA</aff><aff id="A31"><label>31</label>Boston University School of Medicine, Boston, Massachusetts, USA</aff><aff id="A32"><label>32</label>Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, Saint Louis, Missouri, USA</aff><aff id="A33"><label>33</label>The Diabetes Inflammation Laboratory, Cambridge Institute of Medical Research, University of Cambridge, Cambridge, UK</aff><aff id="A34"><label>34</label>Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand</aff><aff id="A35"><label>35</label>Neuroscience Campus Amsterdam, VUA and VUA Medical Center, Amsterdam, The Netherlands</aff><aff id="A36"><label>36</label>National Heart and Lung Institute, Imperial College London, London, UK</aff><aff id="A37"><label>37</label>Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</aff><aff id="A38"><label>38</label>Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</aff><aff id="A39"><label>39</label>IUMSP, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland</aff><aff id="A40"><label>40</label>Cardiology, Department of Medicine, Geneva University Hospital, Geneva, Switzerland</aff><aff id="A41"><label>41</label>The Laboratory in Mjodd, Reykjavik, Iceland</aff><aff id="A42"><label>42</label>Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK</aff><aff id="A43"><label>43</label>Institute of Clinical Chemistry and Laboratory Medicine, University of Greifswald, Germany</aff><aff id="A44"><label>44</label>Genetics and Gastroenterology Divisions, Brigham and Women’s Hospital, Gastrointestinal Cancer Center, Dana-Farber Cancer Institute, Boston, Massachusetts, USA</aff><aff id="A45"><label>45</label>Harvard Medical School, Boston, Massachusetts, USA</aff><aff id="A46"><label>46</label>Harvard Stem Cell Institute, Cambridge, Massachusetts, USA</aff><aff id="A47"><label>47</label>Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, US National Institutes of Health (NIH), Bethesda, Maryland, USA</aff><aff id="A48"><label>48</label>Institute of Clinical Medicine, University of Oulu, Oulu, Finland</aff><aff id="A49"><label>49</label>CEA-IG Centre National de Genotypage, Evry Cedex, France</aff><aff id="A50"><label>50</label>Department of Medicine, University of Toronto, Toronto, Ontario, Canada</aff><aff id="A51"><label>51</label>Liver Center, Toronto Western Hospital, Toronto, Ontario, Canada</aff><aff id="A52"><label>52</label>Centre for Liver Research, University of Birmingham, Birmingham, UK</aff><aff id="A53"><label>53</label>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany</aff><aff id="A54"><label>54</label>Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, UK</aff><aff id="A55"><label>55</label>Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, The Netherlands</aff><aff id="A56"><label>56</label>Clinical Pharmacology and The Genome Center, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK</aff><aff id="A57"><label>57</label>Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</aff><aff id="A58"><label>58</label>Institute of Diagnostic Radiology and Neuroradiology, University of Greifswald, Greifswald, Germany</aff><aff id="A59"><label>59</label>Fondation Jean Dausset Ceph, Paris, France</aff><aff id="A60"><label>60</label>Department of Medicine A, University Medicine Greifswald, Greifswald, Germany</aff><aff id="A61"><label>61</label>Department of Genetics, Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina, USA</aff><aff id="A62"><label>62</label>Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, Maryland, USA</aff><aff id="A63"><label>63</label>Office of Biostatistics Research, Division of Cardiovascular Sciences, National Heart, Lung and Blood Institute (NHLBI), NIH, Bethesda, Maryland, USA</aff><aff id="A64"><label>64</label>Queensland Institute of Medical Research, Brisbane, Queensland, Australia</aff><aff id="A65"><label>65</label>Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA</aff><aff id="A66"><label>66</label>Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA</aff><aff id="A67"><label>67</label>Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA</aff><aff id="A68"><label>68</label>Johns Hopkins University School of Medicine, Baltimore, Maryland, USA</aff><aff id="A69"><label>69</label>NHLBI Framingham Heart Study, Framingham, Massachusetts, USA</aff><aff id="A70"><label>70</label>Department of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Iceland</aff><aff id="A71"><label>71</label>Department of Psychiatry and EMGO Institute for Health and Care Research, VUA Medical Centre, Amsterdam, The Netherlands</aff><aff id="A72"><label>72</label>Department of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands</aff><aff id="A73"><label>73</label>Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</aff><aff id="A74"><label>74</label>Department of Lifecourse and Services, National Institute for Health and Welfare, Oulu, Finland</aff><aff id="A75"><label>75</label>Institute of Diagnostics, Clinical Chemistry, University of Oulu, Oulu, Finland</aff><aff id="A76"><label>76</label>Department of Internal Medicine and Biocenter Oulu, Clinical Research Center, University of Oulu, Oulu, Finland</aff><aff id="A77"><label>77</label>Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, USA</aff><aff id="A78"><label>78</label>Gesellschaft für Arterioskleroseforschung, Leibniz-Institut für Arterioskleroseforschung an der Universität Münster, Münster, Germany</aff><aff id="A79"><label>79</label>Department of Immunology, University of Toronto, Toronto, Ontario, Canada</aff><aff id="A80"><label>80</label>Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada</aff><aff id="A81"><label>81</label>Mount Sinai Hospital Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada</aff><aff id="A82"><label>82</label>Toronto General Research Institute, Toronto, Ontario, Canada</aff><aff id="A83"><label>83</label>Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK</aff><aff id="A84"><label>84</label>Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA</aff><aff id="A85"><label>85</label>Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</aff><aff id="A86"><label>86</label>Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</aff><aff id="A87"><label>87</label>LifeLines Cohort Study and Biobank, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</aff><aff id="A88"><label>88</label>Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, Massachusetts, USA</aff><aff id="A89"><label>89</label>Cardiology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA</aff><aff id="A90"><label>90</label>Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</aff><aff id="A91"><label>91</label>Klinikum Grosshadern, Munich, Germany</aff><aff id="A92"><label>92</label>EMGO<sup>+</sup>Institute, VUA Medical Center, Amsterdam, The Netherlands</aff><aff id="A93"><label>93</label>Samuel Lunenfeld and Toronto General Research Institutes, Toronto, Ontario, Canada</aff><aff id="A94"><label>94</label>Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA</aff><aff id="A95"><label>96</label>Center for Medical Systems Biology, Rotterdam, The Netherlands</aff><aff id="A96"><label>97</label>Genomics of Common Diseases, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK</aff><aff id="A97"><label>98</label>Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Oxford, UK</aff><aff id="A98"><label>99</label>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</aff><aff id="A99"><label>100</label>Obesity Research Unit, Department of Medicine, Division of Internal Medicine, Helsinki University Hospital, Helsinki, Finland</aff><aff id="A100"><label>101</label>The Institute for Molecular Medicine FIMM, Helsinki, Finland</aff><aff id="A101"><label>102</label>Hjelt Institute, Department of Public Health, University of Helsinki, Helsinki, Finland</aff><aff id="A102"><label>103</label>MRC-Social Genetic Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, King’s College, London, UK</aff><aff id="A103"><label>104</label>Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</aff><aff id="A104"><label>105</label>Faculty of Medicine, Imperial College London, London, UK</aff><aff id="A105"><label>106</label>Faculty of Medicine, University of Iceland, Reykjavik, Iceland</aff><aff id="A106"><label>107</label>Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland</aff><aff id="A107"><label>108</label>Division of Endocrinology, Hypertension, and Metabolism, Brigham and Women’s Hospital, Boston, Massachusetts, USA</aff><aff id="A108"><label>109</label>Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, USA</aff><aff id="A109"><label>110</label>Institute of Health Sciences, University of Oulu, Oulu, Finland</aff><aff id="A110"><label>111</label>Biocenter Oulu, University of Oulu, Oulu, Finland</aff><aff id="A111"><label>112</label>MRC–Health Protection Agency (HPA) Centre for Environment and Health, Imperial College London, London, UK</aff><author-notes><corresp id="FN1">Correspondence should be addressed to J.C.C. (<email>john.chambers@ic.ac.uk</email>), P.E. (<email>p.elliott@ic.ac.uk</email>) or J.S.K. (<email>j.kooner@ic.ac.uk</email>)</corresp><fn id="FN2"><label>95</label><p>A full list of members is given in <xref rid="SD1" ref-type="supplementary-material">Supplementary Note</xref>.</p></fn><fn id="FN3" fn-type="equal"><label>113</label><p>These authors contributed equally to this work.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>4</day><month>10</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>16</day><month>10</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>27</day><month>10</month><year>2012</year></pub-date><volume>43</volume><issue>11</issue><fpage>1131</fpage><lpage>1138</lpage><permissions><copyright-statement>© 2011 Nature America, Inc. All rights reserved.</copyright-statement><copyright-year>2011</copyright-year></permissions><abstract><p id="P1">Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci associated with concentrations of liver enzymes in plasma, of which 32 are new associations (<italic>P</italic> = 10<sup>−8</sup> to <italic>P</italic> = 10<sup>−190</sup>). We used functional genomic approaches including metabonomic profiling and gene expression analyses to identify probable candidate genes at these regions. We identified 69 candidate genes, including genes involved in biliary transport (<italic>ATP8B1</italic> and <italic>ABCB11</italic>), glucose, carbohydrate and lipid metabolism (<italic>FADS1</italic>, <italic>FADS2</italic>, <italic>GCKR</italic>, JMJD1C, HNF1A, MLXIPL, PNPLA3, PPP1R3B, SLC2A2 and <italic>TRIB1</italic>), glycoprotein biosynthesis and cell surface glycobiology (<italic>ABO</italic>, <italic>ASGR1</italic>, <italic>FUT2</italic>, <italic>GPLD1</italic> and <italic>ST3GAL4</italic>), inflammation and immunity (<italic>CD276</italic>, <italic>CDH6</italic>, <italic>GCKR</italic>, <italic>HNF1A</italic>, <italic>HPR</italic>, <italic>ITGA1</italic>, <italic>RORA</italic> and <italic>STAT4</italic>) and glutathione metabolism (<italic>GSTT1</italic>, <italic>GSTT2</italic> and <italic>GGT</italic>), as well as several genes of uncertain or unknown function (including <italic>ABHD12</italic>, <italic>EFHD1</italic>, <italic>EFNA1</italic>, <italic>EPHA2</italic>, <italic>MICAL3</italic> and <italic>ZNF827</italic>). Our results provide new insight into genetic mechanisms and pathways influencing markers of liver function.</p></abstract><funding-group><award-group><funding-source country="United States">National Institute of Diabetes and Digestive and Kidney Diseases : NIDDK</funding-source><award-id>ZIA DK075013-05 || DK</award-id></award-group><award-group><funding-source country="United States">National Institute of Diabetes and Digestive and Kidney Diseases : NIDDK</funding-source><award-id>Z99 DK999999 || DK</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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