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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Candidate genetic modifiers for breast and ovarian cancer risk in <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers</title><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="A1">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="A3">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Moysich, Kirsten B" sort="Moysich, Kirsten B" uniqKey="Moysich K" first="Kirsten B." last="Moysich">Kirsten B. Moysich</name><affiliation><nlm:aff id="A4">Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="A3">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="A5">Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Center for Molecular Medicine Cologne (CMMC), University of Cologne, Germany, on behalf of the German Consortium of Hereditary Breast and Ovarian Cancer (GC-HBOC)</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="A8">Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City, Canada</nlm:aff></affiliation></author><author><name sortKey="Soucy, Penny" sort="Soucy, Penny" uniqKey="Soucy P" first="Penny" last="Soucy">Penny Soucy</name><affiliation><nlm:aff id="A8">Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City, Canada</nlm:aff></affiliation></author><author><name sortKey="Eeles, Rosalind A" sort="Eeles, Rosalind A" uniqKey="Eeles R" first="Rosalind A." last="Eeles">Rosalind A. Eeles</name><affiliation><nlm:aff id="A9">Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, UK</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="A10">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="A11">Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Wilkening, Stefan" sort="Wilkening, Stefan" uniqKey="Wilkening S" first="Stefan" last="Wilkening">Stefan Wilkening</name><affiliation><nlm:aff id="A12">Genomic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Chen, Bowang" sort="Chen, Bowang" uniqKey="Chen B" first="Bowang" last="Chen">Bowang Chen</name><affiliation><nlm:aff id="A13">Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Rookus, Matti A" sort="Rookus, Matti A" uniqKey="Rookus M" first="Matti A." last="Rookus">Matti A. Rookus</name><affiliation><nlm:aff id="A14">Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K" last="Schmidt">Marjanka K. Schmidt</name><affiliation><nlm:aff id="A15">Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Der Baan, Frederieke H" sort="Van Der Baan, Frederieke H" uniqKey="Van Der Baan F" first="Frederieke H." last="Van Der Baan">Frederieke H. Van Der Baan</name><affiliation><nlm:aff id="A14">Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B." last="Spurdle">Amanda B. Spurdle</name><affiliation><nlm:aff id="A16">Department of Genetics and Computational Biology, QIMR Berghofer, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Walker, Logan C" sort="Walker, Logan C" uniqKey="Walker L" first="Logan C." last="Walker">Logan C. Walker</name><affiliation><nlm:aff id="A17">Department of Pathology, University of Otago, Christchurch, New Zealand</nlm:aff></affiliation></author><author><name sortKey="Lose, Felicity" sort="Lose, Felicity" uniqKey="Lose F" first="Felicity" last="Lose">Felicity Lose</name><affiliation><nlm:aff id="A16">Department of Genetics and Computational Biology, QIMR Berghofer, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Maia, Ana Teresa" sort="Maia, Ana Teresa" uniqKey="Maia A" first="Ana-Teresa" last="Maia">Ana-Teresa Maia</name><affiliation><nlm:aff id="A18">Department of Biomedical Sciences and Medicine, Gambelas Campus, University of Algarve, Portugal</nlm:aff></affiliation></author><author><name sortKey="Montagna, Marco" sort="Montagna, Marco" uniqKey="Montagna M" first="Marco" last="Montagna">Marco Montagna</name><affiliation><nlm:aff id="A19">Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS, Padua, Italy</nlm:aff></affiliation></author><author><name sortKey="Matricardi, Laura" sort="Matricardi, Laura" uniqKey="Matricardi L" first="Laura" last="Matricardi">Laura Matricardi</name><affiliation><nlm:aff id="A19">Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS, Padua, Italy</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="A20">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="A20">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="G Mez Garcia, Encarna B" sort="G Mez Garcia, Encarna B" uniqKey="G Mez Garcia E" first="Encarna B." last="G Mez Garcia">Encarna B. G Mez Garcia</name><affiliation><nlm:aff id="A21">Department of Clinical Genetics, MUMC, Maastricht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Olopade, Olufunmilayo I" sort="Olopade, Olufunmilayo I" uniqKey="Olopade O" first="Olufunmilayo I." last="Olopade">Olufunmilayo I. Olopade</name><affiliation><nlm:aff id="A22">Center for Clinical Cancer Genetic, Department of Medicine and Human Genetics, University of Chicago Medical Center, Chicago, USA</nlm:aff></affiliation></author><author><name sortKey="Nussbaum, Robert L" sort="Nussbaum, Robert L" uniqKey="Nussbaum R" first="Robert L." last="Nussbaum">Robert L. Nussbaum</name><affiliation><nlm:aff id="A23">Department of Medicine and Institute for Human Genetics, University of California, San Francisco, USA</nlm:aff></affiliation></author><author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L." last="Nathanson">Katherine L. Nathanson</name><affiliation><nlm:aff id="A24">Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Domchek, Susan M" sort="Domchek, Susan M" uniqKey="Domchek S" first="Susan M." last="Domchek">Susan M. Domchek</name><affiliation><nlm:aff id="A24">Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Rebbeck, Timothy R" sort="Rebbeck, Timothy R" uniqKey="Rebbeck T" first="Timothy R." last="Rebbeck">Timothy R. Rebbeck</name><affiliation><nlm:aff id="A25">Department of Epidemiology and Biostatistics, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Arun, Banu K" sort="Arun, Banu K" uniqKey="Arun B" first="Banu K." last="Arun">Banu K. Arun</name><affiliation><nlm:aff id="A26">University of Texas MD Anderson Cancer Center, Houston, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Karlan, Beth Y" sort="Karlan, Beth Y" uniqKey="Karlan B" first="Beth Y." last="Karlan">Beth Y. Karlan</name><affiliation><nlm:aff id="A27">Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, USA</nlm:aff></affiliation></author><author><name sortKey="Orsulic, Sandra" sort="Orsulic, Sandra" uniqKey="Orsulic S" first="Sandra" last="Orsulic">Sandra Orsulic</name><affiliation><nlm:aff id="A27">Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, USA</nlm:aff></affiliation></author><author><name sortKey="Lester, Jenny" sort="Lester, Jenny" uniqKey="Lester J" first="Jenny" last="Lester">Jenny Lester</name><affiliation><nlm:aff id="A27">Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, USA</nlm:aff></affiliation></author><author><name sortKey="Chung, Wendy K" sort="Chung, Wendy K" uniqKey="Chung W" first="Wendy K." last="Chung">Wendy K. Chung</name><affiliation><nlm:aff id="A28">Departments of Pediatrics and Medicine, Columbia University, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Miron, Alex" sort="Miron, Alex" uniqKey="Miron A" first="Alex" last="Miron">Alex Miron</name><affiliation><nlm:aff id="A29">Department of Genetics and Genomics at Case Western Reserve Medical School, Cleveland, Ohio, USA</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="A30">Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Australia</nlm:aff></affiliation></author><author><name sortKey="Goldgar, David E" sort="Goldgar, David E" uniqKey="Goldgar D" first="David E." last="Goldgar">David E. Goldgar</name><affiliation><nlm:aff id="A31">Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, USA</nlm:aff></affiliation></author><author><name sortKey="Buys, Saundra S" sort="Buys, Saundra S" uniqKey="Buys S" first="Saundra S." last="Buys">Saundra S. Buys</name><affiliation><nlm:aff id="A32">Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, USA</nlm:aff></affiliation></author><author><name sortKey="Janavicius, Ramunas" sort="Janavicius, Ramunas" uniqKey="Janavicius R" first="Ramunas" last="Janavicius">Ramunas Janavicius</name><affiliation><nlm:aff id="A33">Vilnius University Hospital Santariskiu Clinics, Hematology, Oncology and Transfusion Medicine Center, Dept. of Molecular and Regenerative Medicine; State Research Institute Centre for Innovative medicine, Vilnius, Lithuania</nlm:aff></affiliation></author><author><name sortKey="Dorfling, Cecilia M" sort="Dorfling, Cecilia M" uniqKey="Dorfling C" first="Cecilia M." last="Dorfling">Cecilia M. Dorfling</name><affiliation><nlm:aff id="A34">Department of Genetics, University of Pretoria, Pretoria, South Africa</nlm:aff></affiliation></author><author><name sortKey="Van Rensburg, Elizabeth J" sort="Van Rensburg, Elizabeth J" uniqKey="Van Rensburg E" first="Elizabeth J." last="Van Rensburg">Elizabeth J. Van Rensburg</name><affiliation><nlm:aff id="A34">Department of Genetics, University of Pretoria, Pretoria, South Africa</nlm:aff></affiliation></author><author><name sortKey="Ding, Yuan Chun" sort="Ding, Yuan Chun" uniqKey="Ding Y" first="Yuan Chun" last="Ding">Yuan Chun Ding</name><affiliation><nlm:aff id="A35">Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name><affiliation><nlm:aff id="A35">Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Hansen, Thomas V O" sort="Hansen, Thomas V O" uniqKey="Hansen T" first="Thomas V. O." last="Hansen">Thomas V. O. Hansen</name><affiliation><nlm:aff id="A36">Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Gerdes, Anne Marie" sort="Gerdes, Anne Marie" uniqKey="Gerdes A" first="Anne-Marie" last="Gerdes">Anne-Marie Gerdes</name><affiliation><nlm:aff id="A37">Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Ejlertsen, Bent" sort="Ejlertsen, Bent" uniqKey="Ejlertsen B" first="Bent" last="Ejlertsen">Bent Ejlertsen</name><affiliation><nlm:aff id="A38">Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="J Nson, Lars" sort="J Nson, Lars" uniqKey="J Nson L" first="Lars" last="J Nson">Lars J Nson</name><affiliation><nlm:aff id="A36">Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Osorio, Ana" sort="Osorio, Ana" uniqKey="Osorio A" first="Ana" last="Osorio">Ana Osorio</name><affiliation><nlm:aff id="A39">Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Martinez Bouzas, Cristina" sort="Martinez Bouzas, Cristina" uniqKey="Martinez Bouzas C" first="Cristina" last="Martínez-Bouzas">Cristina Martínez-Bouzas</name><affiliation><nlm:aff id="A41">Molecular Genetics Laboratory, Department of Biochemistry, Cruces Hospital Barakaldo, 48903-Barakaldo-Bizkaia, Spain</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation><nlm:aff id="A39">Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A42">Human Genetics Group and Genotyping Unit, Spanish National Cancer Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Conway, Edye E" sort="Conway, Edye E" uniqKey="Conway E" first="Edye E." last="Conway">Edye E. Conway</name><affiliation><nlm:aff id="A43">Saint Alphonsus Regional Medical Center, care of City of Hope Clinical Cancer Genetics Community Research Network, Duarte, California 91010, USA</nlm:aff></affiliation></author><author><name sortKey="Blazer, Kathleen R" sort="Blazer, Kathleen R" uniqKey="Blazer K" first="Kathleen R." last="Blazer">Kathleen R. Blazer</name><affiliation><nlm:aff id="A44">Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, California 91010 USA</nlm:aff></affiliation></author><author><name sortKey="Weitzel, Jeffrey N" sort="Weitzel, Jeffrey N" uniqKey="Weitzel J" first="Jeffrey N." last="Weitzel">Jeffrey N. Weitzel</name><affiliation><nlm:aff id="A45">Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, California 91010 USA (for the City of Hope Clinical Cancer Genetics Community Research Network)</nlm:aff></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation><nlm:aff id="A46">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Peissel, Bernard" sort="Peissel, Bernard" uniqKey="Peissel B" first="Bernard" last="Peissel">Bernard Peissel</name><affiliation><nlm:aff id="A46">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Zaffaroni, Daniela" sort="Zaffaroni, Daniela" uniqKey="Zaffaroni D" first="Daniela" last="Zaffaroni">Daniela Zaffaroni</name><affiliation><nlm:aff id="A46">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Scuvera, Giulietta" sort="Scuvera, Giulietta" uniqKey="Scuvera G" first="Giulietta" last="Scuvera">Giulietta Scuvera</name><affiliation><nlm:aff id="A46">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Barile, Monica" sort="Barile, Monica" uniqKey="Barile M" first="Monica" last="Barile">Monica Barile</name><affiliation><nlm:aff id="A47">Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Ficarazzi, Filomena" sort="Ficarazzi, Filomena" uniqKey="Ficarazzi F" first="Filomena" last="Ficarazzi">Filomena Ficarazzi</name><affiliation><nlm:aff id="A1">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Cogentech Cancer Genetic Test Laboratory, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Mariette, Frederique" sort="Mariette, Frederique" uniqKey="Mariette F" first="Frederique" last="Mariette">Frederique Mariette</name><affiliation><nlm:aff id="A1">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Cogentech Cancer Genetic Test Laboratory, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Fortuzzi, Stefano" sort="Fortuzzi, Stefano" uniqKey="Fortuzzi S" first="Stefano" last="Fortuzzi">Stefano Fortuzzi</name><affiliation><nlm:aff id="A1">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Cogentech Cancer Genetic Test Laboratory, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Viel, Alessandra" sort="Viel, Alessandra" uniqKey="Viel A" first="Alessandra" last="Viel">Alessandra Viel</name><affiliation><nlm:aff id="A49">Division of Experimental Oncology 1, CRO Aviano National Cancer Institute, Aviano (PN), Italy</nlm:aff></affiliation></author><author><name sortKey="Giannini, Giuseppe" sort="Giannini, Giuseppe" uniqKey="Giannini G" first="Giuseppe" last="Giannini">Giuseppe Giannini</name><affiliation><nlm:aff id="A50">Department of Molecular Medicine, Sapienza University, Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Papi, Laura" sort="Papi, Laura" uniqKey="Papi L" first="Laura" last="Papi">Laura Papi</name><affiliation><nlm:aff id="A51">Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Martayan, Aline" sort="Martayan, Aline" uniqKey="Martayan A" first="Aline" last="Martayan">Aline Martayan</name><affiliation><nlm:aff id="A52">Unit of Genetic Counseling, Medical Oncology Department, Istituto Nazionale Tumori Regina Elena, Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Tibiletti, Maria Grazia" sort="Tibiletti, Maria Grazia" uniqKey="Tibiletti M" first="Maria Grazia" last="Tibiletti">Maria Grazia Tibiletti</name><affiliation><nlm:aff id="A53">UO Anatomia Patologica, Ospedale di Circolo e Fondazione Macchi, Polo Universitario, Varese, Italy</nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff id="A46">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Vratimos, Athanassios" sort="Vratimos, Athanassios" uniqKey="Vratimos A" first="Athanassios" last="Vratimos">Athanassios Vratimos</name><affiliation><nlm:aff id="A54">Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research “Demokritos”, Aghia Paraskevi Attikis, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Fostira, Florentia" sort="Fostira, Florentia" uniqKey="Fostira F" first="Florentia" last="Fostira">Florentia Fostira</name><affiliation><nlm:aff id="A54">Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research “Demokritos”, Aghia Paraskevi Attikis, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Garber, Judy E" sort="Garber, Judy E" uniqKey="Garber J" first="Judy E." last="Garber">Judy E. Garber</name><affiliation><nlm:aff id="A55">Dana-Farber Cancer Institute, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Donaldson, Alan" sort="Donaldson, Alan" uniqKey="Donaldson A" first="Alan" last="Donaldson">Alan Donaldson</name><affiliation><nlm:aff id="A56">Clinical Genetics Department, St Michael’s Hospital, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Brewer, Carole" sort="Brewer, Carole" uniqKey="Brewer C" first="Carole" last="Brewer">Carole Brewer</name><affiliation><nlm:aff id="A57">Department of Clinical Genetics, Royal Devon & Exeter Hospital, Exeter, UK</nlm:aff></affiliation></author><author><name sortKey="Foo, Claire" sort="Foo, Claire" uniqKey="Foo C" first="Claire" last="Foo">Claire Foo</name><affiliation><nlm:aff id="A58">Cheshire & Merseyside Clinical Genetics Service, Liverpool Women’s NHS Foundation Trust, Liverpool, UK</nlm:aff></affiliation></author><author><name sortKey="Evans, D Gareth R" sort="Evans, D Gareth R" uniqKey="Evans D" first="D. Gareth R." last="Evans">D. Gareth R. Evans</name><affiliation><nlm:aff id="A59">Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK</nlm:aff></affiliation></author><author><name sortKey="Frost, Debra" sort="Frost, Debra" uniqKey="Frost D" first="Debra" last="Frost">Debra Frost</name><affiliation><nlm:aff id="A10">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Eccles, Diana" sort="Eccles, Diana" uniqKey="Eccles D" first="Diana" last="Eccles">Diana Eccles</name><affiliation><nlm:aff id="A60">University of Southampton, Faculty of Medicine, Southampton University Hospitals NHS Trust, Southampton, UK</nlm:aff></affiliation></author><author><name sortKey="Brady, Angela" sort="Brady, Angela" uniqKey="Brady A" first="Angela" last="Brady">Angela Brady</name><affiliation><nlm:aff id="A61">North West Thames Regional Genetics Service, Kennedy-Galton Centre, Harrow, UK</nlm:aff></affiliation></author><author><name sortKey="Cook, Jackie" sort="Cook, Jackie" uniqKey="Cook J" first="Jackie" last="Cook">Jackie Cook</name><affiliation><nlm:aff id="A62">Sheffield Clinical Genetics Service, Sheffield Children’s Hospital, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Tischkowitz, Marc" sort="Tischkowitz, Marc" uniqKey="Tischkowitz M" first="Marc" last="Tischkowitz">Marc Tischkowitz</name><affiliation><nlm:aff id="A63">Department of Clinical Genetics, East Anglian Regional Genetics Service, Addenbrookes Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Adlard, Julian" sort="Adlard, Julian" uniqKey="Adlard J" first="Julian" last="Adlard">Julian Adlard</name><affiliation><nlm:aff id="A64">Yorkshire Regional Genetics Service, Leeds, UK</nlm:aff></affiliation></author><author><name sortKey="Barwell, Julian" sort="Barwell, Julian" uniqKey="Barwell J" first="Julian" last="Barwell">Julian Barwell</name><affiliation><nlm:aff id="A65">Leicestershire Clinical Genetics Service, University Hospitals of Leicester NHS Trust, UK</nlm:aff></affiliation></author><author><name sortKey="Walker, Lisa" sort="Walker, Lisa" uniqKey="Walker L" first="Lisa" last="Walker">Lisa Walker</name><affiliation><nlm:aff id="A66">Oxford Regional Genetics Service, Churchill Hospital, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Izatt, Louise" sort="Izatt, Louise" uniqKey="Izatt L" first="Louise" last="Izatt">Louise Izatt</name><affiliation><nlm:aff id="A67">Clinical Genetics, Guy’s and St. Thomas’ NHS Foundation Trust, London, UK</nlm:aff></affiliation></author><author><name sortKey="Side, Lucy E" sort="Side, Lucy E" uniqKey="Side L" first="Lucy E." last="Side">Lucy E. Side</name><affiliation><nlm:aff id="A68">North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kennedy, M John" sort="Kennedy, M John" uniqKey="Kennedy M" first="M. John" last="Kennedy">M. John Kennedy</name><affiliation><nlm:aff id="A69">Academic Unit of Clinical and Molecular Oncology, Trinity College Dublin, Eire</nlm:aff></affiliation><affiliation><nlm:aff id="A70">St James’s Hospital, Dublin, Ireland</nlm:aff></affiliation></author><author><name sortKey="Rogers, Mark T" sort="Rogers, Mark T" uniqKey="Rogers M" first="Mark T." last="Rogers">Mark T. Rogers</name><affiliation><nlm:aff id="A71">All Wales Medical Genetics Services, University Hospital of Wales, Cardiff, UK</nlm:aff></affiliation></author><author><name sortKey="Porteous, Mary E" sort="Porteous, Mary E" uniqKey="Porteous M" first="Mary E." last="Porteous">Mary E. Porteous</name><affiliation><nlm:aff id="A72">South East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Morrison, Patrick J" sort="Morrison, Patrick J" uniqKey="Morrison P" first="Patrick J." last="Morrison">Patrick J. Morrison</name><affiliation><nlm:aff id="A73">Centre for Cancer Research and Cell Biology, Queens University of Belfast, Department of Medical Genetics, Belfast HSC Trust, Belfast, UK</nlm:aff></affiliation></author><author><name sortKey="Platte, Radka" sort="Platte, Radka" uniqKey="Platte R" first="Radka" last="Platte">Radka Platte</name><affiliation><nlm:aff id="A10">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Davidson, Rosemarie" sort="Davidson, Rosemarie" uniqKey="Davidson R" first="Rosemarie" last="Davidson">Rosemarie Davidson</name><affiliation><nlm:aff id="A74">West of Scotland Regional Genetics Service, Southern General Hospital, Glasgow</nlm:aff></affiliation></author><author><name sortKey="Hodgson, Shirley V" sort="Hodgson, Shirley V" uniqKey="Hodgson S" first="Shirley V." last="Hodgson">Shirley V. Hodgson</name><affiliation><nlm:aff id="A75">Medical Genetics Unit, St George’s, University of London, UK</nlm:aff></affiliation></author><author><name sortKey="Ellis, Steve" sort="Ellis, Steve" uniqKey="Ellis S" first="Steve" last="Ellis">Steve Ellis</name><affiliation><nlm:aff id="A10">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Cole, Trevor" sort="Cole, Trevor" uniqKey="Cole T" first="Trevor" last="Cole">Trevor Cole</name><affiliation><nlm:aff id="A76">West Midlands Regional Genetics Service, Birmingham Women’s Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK</nlm:aff></affiliation></author><author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K." last="Godwin">Andrew K. Godwin</name><affiliation><nlm:aff id="A77">Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA</nlm:aff></affiliation></author><author><name sortKey="Claes, Kathleen" sort="Claes, Kathleen" uniqKey="Claes K" first="Kathleen" last="Claes">Kathleen Claes</name><affiliation><nlm:aff id="A78">Center for Medical Genetics, Ghent University, Ghent, Belgium</nlm:aff></affiliation></author><author><name sortKey="Van Maerken, Tom" sort="Van Maerken, Tom" uniqKey="Van Maerken T" first="Tom" last="Van Maerken">Tom Van Maerken</name><affiliation><nlm:aff id="A78">Center for Medical Genetics, Ghent University, Ghent, Belgium</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="A79">Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Gehrig, Andrea" sort="Gehrig, Andrea" uniqKey="Gehrig A" first="Andrea" last="Gehrig">Andrea Gehrig</name><affiliation><nlm:aff id="A80">Institute of Human Genetics, University Würzburg, Wurzburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Sutter, Christian" sort="Sutter, Christian" uniqKey="Sutter C" first="Christian" last="Sutter">Christian Sutter</name><affiliation><nlm:aff id="A81">University Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Engel, Christoph" sort="Engel, Christoph" uniqKey="Engel C" first="Christoph" last="Engel">Christoph Engel</name><affiliation><nlm:aff id="A82">Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Niederacher, Dieter" sort="Niederacher, Dieter" uniqKey="Niederacher D" first="Dieter" last="Niederacher">Dieter Niederacher</name><affiliation><nlm:aff id="A83">University Düsseldorf, Dusseldorf, Germany</nlm:aff></affiliation></author><author><name sortKey="Steinemann, Doris" sort="Steinemann, Doris" uniqKey="Steinemann D" first="Doris" last="Steinemann">Doris Steinemann</name><affiliation><nlm:aff id="A84">Hannover Medical School, Hanover, Germany</nlm:aff></affiliation></author><author><name sortKey="Plendl, Hansjoerg" sort="Plendl, Hansjoerg" uniqKey="Plendl H" first="Hansjoerg" last="Plendl">Hansjoerg Plendl</name><affiliation><nlm:aff id="A85">Institute of Human Genetics, University Hospital of Schleswig-Holstein/University Kiel, Kiel, Germany</nlm:aff></affiliation></author><author><name sortKey="Kast, Karin" sort="Kast, Karin" uniqKey="Kast K" first="Karin" last="Kast">Karin Kast</name><affiliation><nlm:aff id="A86">Department of Gynecology and Obstetrics, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Rhiem, Kerstin" sort="Rhiem, Kerstin" uniqKey="Rhiem K" first="Kerstin" last="Rhiem">Kerstin Rhiem</name><affiliation><nlm:aff id="A5">Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A87">Center for Molecular Medicine Cologne (CMMC), University of Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Ditsch, Nina" sort="Ditsch, Nina" uniqKey="Ditsch N" first="Nina" last="Ditsch">Nina Ditsch</name><affiliation><nlm:aff id="A88">Department of Gynaecology and Obstetrics, University Munich, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Arnold, Norbert" sort="Arnold, Norbert" uniqKey="Arnold N" first="Norbert" last="Arnold">Norbert Arnold</name><affiliation><nlm:aff id="A89">Department of Gynecology and Obstetrics, University Hospital of Schleswig-Holstein/University Kiel, Kiel, Germany</nlm:aff></affiliation></author><author><name sortKey="Varon Mateeva, Raymonda" sort="Varon Mateeva, Raymonda" uniqKey="Varon Mateeva R" first="Raymonda" last="Varon-Mateeva">Raymonda Varon-Mateeva</name><affiliation><nlm:aff id="A90">Institute of Human Genetics, Charite Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Wappenschmidt, Barbara" sort="Wappenschmidt, Barbara" uniqKey="Wappenschmidt B" first="Barbara" last="Wappenschmidt">Barbara Wappenschmidt</name><affiliation><nlm:aff id="A5">Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A87">Center for Molecular Medicine Cologne (CMMC), University of Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Wang Gohrke, Shan" sort="Wang Gohrke, Shan" uniqKey="Wang Gohrke S" first="Shan" last="Wang-Gohrke">Shan Wang-Gohrke</name><affiliation><nlm:aff id="A91">Department of Gynaecology and Obstetrics, University Hospital Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Bressac De Paillerets, Brigitte" sort="Bressac De Paillerets, Brigitte" uniqKey="Bressac De Paillerets B" first="Brigitte" last="Bressac-De Paillerets">Brigitte Bressac-De Paillerets</name><affiliation><nlm:aff id="A92">INSERM U946, Fondation Jean Dausset, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A93">Service de Génétique, Institut de Cancérologie Gustave Roussy, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Buecher, Bruno" sort="Buecher, Bruno" uniqKey="Buecher B" first="Bruno" last="Buecher">Bruno Buecher</name><affiliation><nlm:aff id="A94">Institut Curie, Department of Tumour Biology, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Delnatte, Capucine" sort="Delnatte, Capucine" uniqKey="Delnatte C" first="Capucine" last="Delnatte">Capucine Delnatte</name><affiliation><nlm:aff id="A95">Centre René Gauducheau, Nantes, France</nlm:aff></affiliation></author><author><name sortKey="Houdayer, Claude" sort="Houdayer, Claude" uniqKey="Houdayer C" first="Claude" last="Houdayer">Claude Houdayer</name><affiliation><nlm:aff id="A94">Institut Curie, Department of Tumour Biology, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A96">Université Paris Descartes, Sorbonne Paris Cité, France</nlm:aff></affiliation></author><author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name><affiliation><nlm:aff id="A94">Institut Curie, Department of Tumour Biology, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A96">Université Paris Descartes, Sorbonne Paris Cité, France</nlm:aff></affiliation><affiliation><nlm:aff id="A97">Institut Curie, INSERM U830, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Damiola, Francesca" sort="Damiola, Francesca" uniqKey="Damiola F" first="Francesca" last="Damiola">Francesca Damiola</name><affiliation><nlm:aff id="A98">INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Coupier, Isabelle" sort="Coupier, Isabelle" uniqKey="Coupier I" first="Isabelle" last="Coupier">Isabelle Coupier</name><affiliation><nlm:aff id="A99">Unité d’Oncogénétique, CHU Arnaud de Villeneuve, Montpellier, France</nlm:aff></affiliation><affiliation><nlm:aff id="A100">Unité d’Oncogénétique, CRLCC Val d’Aurelle, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Barjhoux, Laure" sort="Barjhoux, Laure" uniqKey="Barjhoux L" first="Laure" last="Barjhoux">Laure Barjhoux</name><affiliation><nlm:aff id="A100">Unité d’Oncogénétique, CRLCC Val d’Aurelle, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Venat Bouvet, Laurence" sort="Venat Bouvet, Laurence" uniqKey="Venat Bouvet L" first="Laurence" last="Venat-Bouvet">Laurence Venat-Bouvet</name><affiliation><nlm:aff id="A101">Department of Medical Oncology, Centre Hospitalier Universitaire Dupuytren, Limoges, France</nlm:aff></affiliation></author><author><name sortKey="Golmard, Lisa" sort="Golmard, Lisa" uniqKey="Golmard L" first="Lisa" last="Golmard">Lisa Golmard</name><affiliation><nlm:aff id="A94">Institut Curie, Department of Tumour Biology, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Boutry Kryza, Nadia" sort="Boutry Kryza, Nadia" uniqKey="Boutry Kryza N" first="Nadia" last="Boutry-Kryza">Nadia Boutry-Kryza</name><affiliation><nlm:aff id="A102">Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon – Centre Léon Bérard, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Sinilnikova, Olga M" sort="Sinilnikova, Olga M" uniqKey="Sinilnikova O" first="Olga M." last="Sinilnikova">Olga M. Sinilnikova</name><affiliation><nlm:aff id="A98">INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="A102">Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon – Centre Léon Bérard, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Caron, Olivier" sort="Caron, Olivier" uniqKey="Caron O" first="Olivier" last="Caron">Olivier Caron</name><affiliation><nlm:aff id="A103">Consultation de Génétique, Département de Médecine, Institut de Cancérologie Gustave Roussy, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Pujol, Pascal" sort="Pujol, Pascal" uniqKey="Pujol P" first="Pascal" last="Pujol">Pascal Pujol</name><affiliation><nlm:aff id="A99">Unité d’Oncogénétique, CHU Arnaud de Villeneuve, Montpellier, France</nlm:aff></affiliation><affiliation><nlm:aff id="A104">INSERM 896, CRCM Val d’Aurelle, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Mazoyer, Sylvie" sort="Mazoyer, Sylvie" uniqKey="Mazoyer S" first="Sylvie" last="Mazoyer">Sylvie Mazoyer</name><affiliation><nlm:aff id="A98">INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Belotti, Muriel" sort="Belotti, Muriel" uniqKey="Belotti M" first="Muriel" last="Belotti">Muriel Belotti</name><affiliation><nlm:aff id="A94">Institut Curie, Department of Tumour Biology, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Piedmonte, Marion" sort="Piedmonte, Marion" uniqKey="Piedmonte M" first="Marion" last="Piedmonte">Marion Piedmonte</name><affiliation><nlm:aff id="A106">Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Friedlander, Michael L" sort="Friedlander, Michael L" uniqKey="Friedlander M" first="Michael L." last="Friedlander">Michael L. Friedlander</name><affiliation><nlm:aff id="A107">Australia New Zealand Gynaecological Oncology Group (ANZGOG), Coordinating Centre, Camperdown, Australia</nlm:aff></affiliation></author><author><name sortKey="Rodriguez, Gustavo C" sort="Rodriguez, Gustavo C" uniqKey="Rodriguez G" first="Gustavo C." last="Rodriguez">Gustavo C. Rodriguez</name><affiliation><nlm:aff id="A108">Division of Gynecologic Oncology, NorthShore University HealthSystem, Evanston, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Copeland, Larry J" sort="Copeland, Larry J" uniqKey="Copeland L" first="Larry J" last="Copeland">Larry J. Copeland</name><affiliation><nlm:aff id="A109">Ohio State University, Department of Obstetrics and Gynecology, Hilliard, OH, USA</nlm:aff></affiliation></author><author><name sortKey="De La Hoya, Miguel" sort="De La Hoya, Miguel" uniqKey="De La Hoya M" first="Miguel" last="De La Hoya">Miguel De La Hoya</name><affiliation><nlm:aff id="A110">Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Segura, Pedro Perez" sort="Segura, Pedro Perez" uniqKey="Segura P" first="Pedro Perez" last="Segura">Pedro Perez Segura</name><affiliation><nlm:aff id="A111">Department of Oncology, Hospital Clinico San Carlos, IdISSC, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="A112">Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A113">University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff id="A114">Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Van Os, Theo A M" sort="Van Os, Theo A M" uniqKey="Van Os T" first="Theo A. M." last="Van Os">Theo A. M. Van Os</name><affiliation><nlm:aff id="A115">Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Meijers Heijboer, Hanne E J" sort="Meijers Heijboer, Hanne E J" uniqKey="Meijers Heijboer H" first="Hanne E. J." last="Meijers-Heijboer">Hanne E. J. Meijers-Heijboer</name><affiliation><nlm:aff id="A116">Department of Clinical Genetics, VU University Medical Centre, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Der Hout, Annemarie H" sort="Van Der Hout, Annemarie H" uniqKey="Van Der Hout A" first="Annemarie H." last="Van Der Hout">Annemarie H. Van Der Hout</name><affiliation><nlm:aff id="A117">Department of Genetics, University Medical Center, Groningen University, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Vreeswijk, Maaike P G" sort="Vreeswijk, Maaike P G" uniqKey="Vreeswijk M" first="Maaike P. G." last="Vreeswijk">Maaike P. G. Vreeswijk</name><affiliation><nlm:aff id="A118">Department of Human Genetics, Leiden University Medical Center (LUMC), Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hoogerbrugge, Nicoline" sort="Hoogerbrugge, Nicoline" uniqKey="Hoogerbrugge N" first="Nicoline" last="Hoogerbrugge">Nicoline Hoogerbrugge</name><affiliation><nlm:aff id="A119">Department of Human Genetics, Radboud University Medical Centre, Nijmegen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Ausems, Margreet G E M" sort="Ausems, Margreet G E M" uniqKey="Ausems M" first="Margreet G. E. M." last="Ausems">Margreet G. E. M. Ausems</name><affiliation><nlm:aff id="A120">Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Doorn, Helena C" sort="Van Doorn, Helena C" uniqKey="Van Doorn H" first="Helena C." last="Van Doorn">Helena C. Van Doorn</name><affiliation><nlm:aff id="A121">Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Erasmus University MC Cancer Institute, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Collee, J Margriet" sort="Collee, J Margriet" uniqKey="Collee J" first="J. Margriet" last="Collée">J. Margriet Collée</name><affiliation><nlm:aff id="A122">Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Olah, Edith" sort="Olah, Edith" uniqKey="Olah E" first="Edith" last="Olah">Edith Olah</name><affiliation><nlm:aff id="A123">Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary</nlm:aff></affiliation></author><author><name sortKey="Diez, Orland" sort="Diez, Orland" uniqKey="Diez O" first="Orland" last="Diez">Orland Diez</name><affiliation><nlm:aff id="A124">Oncogenetics Group, University Hospital Vall d’Hebron, Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A125">Universitat Autònoma de Barcelona, Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A126">Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A127">Vall d’Hebron Research Institute (VHIR), Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Blanco, Ignacio" sort="Blanco, Ignacio" uniqKey="Blanco I" first="Ignacio" last="Blanco">Ignacio Blanco</name><affiliation><nlm:aff id="A128">Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Lazaro, Conxi" sort="Lazaro, Conxi" uniqKey="Lazaro C" first="Conxi" last="Lazaro">Conxi Lazaro</name><affiliation><nlm:aff id="A129">Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Brunet, Joan" sort="Brunet, Joan" uniqKey="Brunet J" first="Joan" last="Brunet">Joan Brunet</name><affiliation><nlm:aff id="A130">Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI-Catalan Institute of Oncology, Girona, Spain</nlm:aff></affiliation></author><author><name sortKey="Feliubadalo, Lidia" sort="Feliubadalo, Lidia" uniqKey="Feliubadalo L" first="Lidia" last="Feliubadalo">Lidia Feliubadalo</name><affiliation><nlm:aff id="A131">BMC, Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Cybulski, Cezary" sort="Cybulski, Cezary" uniqKey="Cybulski C" first="Cezary" last="Cybulski">Cezary Cybulski</name><affiliation><nlm:aff id="A20">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Gronwald, Jacek" sort="Gronwald, Jacek" uniqKey="Gronwald J" first="Jacek" last="Gronwald">Jacek Gronwald</name><affiliation><nlm:aff id="A20">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name><affiliation><nlm:aff id="A20">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Jaworska Bieniek, Katarzyna" sort="Jaworska Bieniek, Katarzyna" uniqKey="Jaworska Bieniek K" first="Katarzyna" last="Jaworska-Bieniek">Katarzyna Jaworska-Bieniek</name><affiliation><nlm:aff id="A20">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Sukiennicki, Grzegorz" sort="Sukiennicki, Grzegorz" uniqKey="Sukiennicki G" first="Grzegorz" last="Sukiennicki">Grzegorz Sukiennicki</name><affiliation><nlm:aff id="A20">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Arason, Adalgeir" sort="Arason, Adalgeir" uniqKey="Arason A" first="Adalgeir" last="Arason">Adalgeir Arason</name><affiliation><nlm:aff id="A131">BMC, Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A132">Department of Pathology, Landspitali University Hospital, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Chiquette, Jocelyne" sort="Chiquette, Jocelyne" uniqKey="Chiquette J" first="Jocelyne" last="Chiquette">Jocelyne Chiquette</name><affiliation><nlm:aff id="A133">Unité de Recherche en Santé des Populations, Centre des Maladies du Sein Deschênes-Fabia, Centre de Recherche FRSQ du Centre Hospitalier Affilié Universitaire de Québec, Québec, QC, Canada</nlm:aff></affiliation></author><author><name sortKey="Teixeira, Manuel R" sort="Teixeira, Manuel R" uniqKey="Teixeira M" first="Manuel R." last="Teixeira">Manuel R. Teixeira</name><affiliation><nlm:aff id="A134">Biomedical Sciences Institute (ICBAS), Porto University, Porto, Portugal</nlm:aff></affiliation><affiliation><nlm:aff id="A135">Department of Genetics, Portuguese Oncology Institute, Porto, Portugal</nlm:aff></affiliation></author><author><name sortKey="Olswold, Curtis" sort="Olswold, Curtis" uniqKey="Olswold C" first="Curtis" last="Olswold">Curtis Olswold</name><affiliation><nlm:aff id="A136">Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="A137">Department of Laboratory Medicine and Pathology, and Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Lindor, Noralane M" sort="Lindor, Noralane M" uniqKey="Lindor N" first="Noralane M." last="Lindor">Noralane M. Lindor</name><affiliation><nlm:aff id="A138">Health Sciences Research, Mayo Clinic, Scottsdale, AZ, USA</nlm:aff></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation><nlm:aff id="A139">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Szabo, Csilla I" sort="Szabo, Csilla I" uniqKey="Szabo C" first="Csilla I." last="Szabo">Csilla I. Szabo</name><affiliation><nlm:aff id="A140">National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name><affiliation><nlm:aff id="A141">Clinical Genetics Research Laboratory, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Corines, Marina" sort="Corines, Marina" uniqKey="Corines M" first="Marina" last="Corines">Marina Corines</name><affiliation><nlm:aff id="A142">Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Jacobs, Lauren" sort="Jacobs, Lauren" uniqKey="Jacobs L" first="Lauren" last="Jacobs">Lauren Jacobs</name><affiliation><nlm:aff id="A142">Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Robson, Mark E" sort="Robson, Mark E" uniqKey="Robson M" first="Mark E." last="Robson">Mark E. Robson</name><affiliation><nlm:aff id="A141">Clinical Genetics Research Laboratory, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Zhang, Liying" sort="Zhang, Liying" uniqKey="Zhang L" first="Liying" last="Zhang">Liying Zhang</name><affiliation><nlm:aff id="A143">Diagnostic Molecular Genetics Laboratory, Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Joseph, Vijai" sort="Joseph, Vijai" uniqKey="Joseph V" first="Vijai" last="Joseph">Vijai Joseph</name><affiliation><nlm:aff id="A141">Clinical Genetics Research Laboratory, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Berger, Andreas" sort="Berger, Andreas" uniqKey="Berger A" first="Andreas" last="Berger">Andreas Berger</name><affiliation><nlm:aff id="A144">Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Singer, Christian F" sort="Singer, Christian F" uniqKey="Singer C" first="Christian F." last="Singer">Christian F. Singer</name><affiliation><nlm:aff id="A144">Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Rappaport, Christine" sort="Rappaport, Christine" uniqKey="Rappaport C" first="Christine" last="Rappaport">Christine Rappaport</name><affiliation><nlm:aff id="A144">Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Kaulich, Daphne Geschwantler" sort="Kaulich, Daphne Geschwantler" uniqKey="Kaulich D" first="Daphne Geschwantler" last="Kaulich">Daphne Geschwantler Kaulich</name><affiliation><nlm:aff id="A144">Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Pfeiler, Georg" sort="Pfeiler, Georg" uniqKey="Pfeiler G" first="Georg" last="Pfeiler">Georg Pfeiler</name><affiliation><nlm:aff id="A144">Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Tea, Muy Kheng M" sort="Tea, Muy Kheng M" uniqKey="Tea M" first="Muy-Kheng M." last="Tea">Muy-Kheng M. Tea</name><affiliation><nlm:aff id="A144">Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Phelan, Catherine M" sort="Phelan, Catherine M" uniqKey="Phelan C" first="Catherine M." last="Phelan">Catherine M. Phelan</name><affiliation><nlm:aff id="A145">Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA</nlm:aff></affiliation></author><author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H." last="Greene">Mark H. Greene</name><affiliation><nlm:aff id="A146">Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Mai, Phuong L" sort="Mai, Phuong L" uniqKey="Mai P" first="Phuong L." last="Mai">Phuong L. Mai</name><affiliation><nlm:aff id="A146">Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name><affiliation><nlm:aff id="A147">Clalit National Cancer Control Center, Haifa, Israel</nlm:aff></affiliation></author><author><name sortKey="Mulligan, Anna Marie" sort="Mulligan, Anna Marie" uniqKey="Mulligan A" first="Anna Marie" last="Mulligan">Anna Marie Mulligan</name><affiliation><nlm:aff id="A148">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A149">Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation><nlm:aff id="A150">Ontario Cancer Genetics Network: Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Tchatchou, Sandrine" sort="Tchatchou, Sandrine" uniqKey="Tchatchou S" first="Sandrine" last="Tchatchou">Sandrine Tchatchou</name><affiliation><nlm:aff id="A151">Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="A151">Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A152">Departments of Molecular Genetics and Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Toland, Amanda Ewart" sort="Toland, Amanda Ewart" uniqKey="Toland A" first="Amanda Ewart" last="Toland">Amanda Ewart Toland</name><affiliation><nlm:aff id="A153">Division of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Anders" sort="Bojesen, Anders" uniqKey="Bojesen A" first="Anders" last="Bojesen">Anders Bojesen</name><affiliation><nlm:aff id="A154">Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark</nlm:aff></affiliation></author><author><name sortKey="Pedersen, Inge Sokilde" sort="Pedersen, Inge Sokilde" uniqKey="Pedersen I" first="Inge Sokilde" last="Pedersen">Inge Sokilde Pedersen</name><affiliation><nlm:aff id="A155">Section of Molecular Diagnostics, Department of Biochemistry, Aalborg University Hospital, Aalborg, Denmark</nlm:aff></affiliation></author><author><name sortKey="Thomassen, Mads" sort="Thomassen, Mads" uniqKey="Thomassen M" first="Mads" last="Thomassen">Mads Thomassen</name><affiliation><nlm:aff id="A156">Department of Clinical Genetics, Odense University Hospital, Odense C, Denmark</nlm:aff></affiliation></author><author><name sortKey="Jensen, Uffe Birk" sort="Jensen, Uffe Birk" uniqKey="Jensen U" first="Uffe Birk" last="Jensen">Uffe Birk Jensen</name><affiliation><nlm:aff id="A157">Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark</nlm:aff></affiliation></author><author><name sortKey="Laitman, Yael" sort="Laitman, Yael" uniqKey="Laitman Y" first="Yael" last="Laitman">Yael Laitman</name><affiliation><nlm:aff id="A158">Sheba Medical Center, Tel Aviv, Israel</nlm:aff></affiliation></author><author><name sortKey="Rantala, Johanna" sort="Rantala, Johanna" uniqKey="Rantala J" first="Johanna" last="Rantala">Johanna Rantala</name><affiliation><nlm:aff id="A159">Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Von Wachenfeldt, Anna" sort="Von Wachenfeldt, Anna" uniqKey="Von Wachenfeldt A" first="Anna" last="Von Wachenfeldt">Anna Von Wachenfeldt</name><affiliation><nlm:aff id="A160">Department of Oncology, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Ehrencrona, Hans" sort="Ehrencrona, Hans" uniqKey="Ehrencrona H" first="Hans" last="Ehrencrona">Hans Ehrencrona</name><affiliation><nlm:aff id="A161">Department of Clinical Genetics, Lund University Hospital, Lund, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A162">Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Askmalm, Marie Stenmark" sort="Askmalm, Marie Stenmark" uniqKey="Askmalm M" first="Marie Stenmark" last="Askmalm">Marie Stenmark Askmalm</name><affiliation><nlm:aff id="A163">Division of Clinical Genetics, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden</nlm:aff></affiliation></author><author><name sortKey="Borg, Ke" sort="Borg, Ke" uniqKey="Borg " first=" Ke" last="Borg"> Ke Borg</name><affiliation><nlm:aff id="A164">Department of Oncology, Lund University, Lund, Sweden</nlm:aff></affiliation></author><author><name sortKey="Kuchenbaecker, Karoline B" sort="Kuchenbaecker, Karoline B" uniqKey="Kuchenbaecker K" first="Karoline B." last="Kuchenbaecker">Karoline B. Kuchenbaecker</name><affiliation><nlm:aff id="A10">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name><affiliation><nlm:aff id="A10">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Barrowdale, Daniel" sort="Barrowdale, Daniel" uniqKey="Barrowdale D" first="Daniel" last="Barrowdale">Daniel Barrowdale</name><affiliation><nlm:aff id="A10">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Healey, Sue" sort="Healey, Sue" uniqKey="Healey S" first="Sue" last="Healey">Sue Healey</name><affiliation><nlm:aff id="A16">Department of Genetics and Computational Biology, QIMR Berghofer, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Lee, Andrew" sort="Lee, Andrew" uniqKey="Lee A" first="Andrew" last="Lee">Andrew Lee</name><affiliation><nlm:aff id="A10">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name><affiliation><nlm:aff id="A165">Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="A16">Department of Genetics and Computational Biology, QIMR Berghofer, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C." last="Antoniou">Antonis C. Antoniou</name><affiliation><nlm:aff id="A10">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name><affiliation><nlm:aff id="A158">Sheba Medical Center, Tel Aviv, Israel</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25336561</idno><idno type="pmc">4294951</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294951</idno><idno type="RBID">PMC:4294951</idno><idno type="doi">10.1158/1055-9965.EPI-14-0532</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002095</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002095</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Candidate genetic modifiers for breast and ovarian cancer risk in <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers</title><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="A1">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="A3">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Moysich, Kirsten B" sort="Moysich, Kirsten B" uniqKey="Moysich K" first="Kirsten B." last="Moysich">Kirsten B. Moysich</name><affiliation><nlm:aff id="A4">Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="A3">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="A5">Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Center for Molecular Medicine Cologne (CMMC), University of Cologne, Germany, on behalf of the German Consortium of Hereditary Breast and Ovarian Cancer (GC-HBOC)</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="A8">Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City, Canada</nlm:aff></affiliation></author><author><name sortKey="Soucy, Penny" sort="Soucy, Penny" uniqKey="Soucy P" first="Penny" last="Soucy">Penny Soucy</name><affiliation><nlm:aff id="A8">Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City, Canada</nlm:aff></affiliation></author><author><name sortKey="Eeles, Rosalind A" sort="Eeles, Rosalind A" uniqKey="Eeles R" first="Rosalind A." last="Eeles">Rosalind A. Eeles</name><affiliation><nlm:aff id="A9">Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, UK</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="A10">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="A11">Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Wilkening, Stefan" sort="Wilkening, Stefan" uniqKey="Wilkening S" first="Stefan" last="Wilkening">Stefan Wilkening</name><affiliation><nlm:aff id="A12">Genomic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Chen, Bowang" sort="Chen, Bowang" uniqKey="Chen B" first="Bowang" last="Chen">Bowang Chen</name><affiliation><nlm:aff id="A13">Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Rookus, Matti A" sort="Rookus, Matti A" uniqKey="Rookus M" first="Matti A." last="Rookus">Matti A. Rookus</name><affiliation><nlm:aff id="A14">Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K" last="Schmidt">Marjanka K. Schmidt</name><affiliation><nlm:aff id="A15">Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Der Baan, Frederieke H" sort="Van Der Baan, Frederieke H" uniqKey="Van Der Baan F" first="Frederieke H." last="Van Der Baan">Frederieke H. Van Der Baan</name><affiliation><nlm:aff id="A14">Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B." last="Spurdle">Amanda B. Spurdle</name><affiliation><nlm:aff id="A16">Department of Genetics and Computational Biology, QIMR Berghofer, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Walker, Logan C" sort="Walker, Logan C" uniqKey="Walker L" first="Logan C." last="Walker">Logan C. Walker</name><affiliation><nlm:aff id="A17">Department of Pathology, University of Otago, Christchurch, New Zealand</nlm:aff></affiliation></author><author><name sortKey="Lose, Felicity" sort="Lose, Felicity" uniqKey="Lose F" first="Felicity" last="Lose">Felicity Lose</name><affiliation><nlm:aff id="A16">Department of Genetics and Computational Biology, QIMR Berghofer, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Maia, Ana Teresa" sort="Maia, Ana Teresa" uniqKey="Maia A" first="Ana-Teresa" last="Maia">Ana-Teresa Maia</name><affiliation><nlm:aff id="A18">Department of Biomedical Sciences and Medicine, Gambelas Campus, University of Algarve, Portugal</nlm:aff></affiliation></author><author><name sortKey="Montagna, Marco" sort="Montagna, Marco" uniqKey="Montagna M" first="Marco" last="Montagna">Marco Montagna</name><affiliation><nlm:aff id="A19">Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS, Padua, Italy</nlm:aff></affiliation></author><author><name sortKey="Matricardi, Laura" sort="Matricardi, Laura" uniqKey="Matricardi L" first="Laura" last="Matricardi">Laura Matricardi</name><affiliation><nlm:aff id="A19">Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS, Padua, Italy</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="A20">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="A20">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="G Mez Garcia, Encarna B" sort="G Mez Garcia, Encarna B" uniqKey="G Mez Garcia E" first="Encarna B." last="G Mez Garcia">Encarna B. G Mez Garcia</name><affiliation><nlm:aff id="A21">Department of Clinical Genetics, MUMC, Maastricht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Olopade, Olufunmilayo I" sort="Olopade, Olufunmilayo I" uniqKey="Olopade O" first="Olufunmilayo I." last="Olopade">Olufunmilayo I. Olopade</name><affiliation><nlm:aff id="A22">Center for Clinical Cancer Genetic, Department of Medicine and Human Genetics, University of Chicago Medical Center, Chicago, USA</nlm:aff></affiliation></author><author><name sortKey="Nussbaum, Robert L" sort="Nussbaum, Robert L" uniqKey="Nussbaum R" first="Robert L." last="Nussbaum">Robert L. Nussbaum</name><affiliation><nlm:aff id="A23">Department of Medicine and Institute for Human Genetics, University of California, San Francisco, USA</nlm:aff></affiliation></author><author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L." last="Nathanson">Katherine L. Nathanson</name><affiliation><nlm:aff id="A24">Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Domchek, Susan M" sort="Domchek, Susan M" uniqKey="Domchek S" first="Susan M." last="Domchek">Susan M. Domchek</name><affiliation><nlm:aff id="A24">Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Rebbeck, Timothy R" sort="Rebbeck, Timothy R" uniqKey="Rebbeck T" first="Timothy R." last="Rebbeck">Timothy R. Rebbeck</name><affiliation><nlm:aff id="A25">Department of Epidemiology and Biostatistics, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Arun, Banu K" sort="Arun, Banu K" uniqKey="Arun B" first="Banu K." last="Arun">Banu K. Arun</name><affiliation><nlm:aff id="A26">University of Texas MD Anderson Cancer Center, Houston, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Karlan, Beth Y" sort="Karlan, Beth Y" uniqKey="Karlan B" first="Beth Y." last="Karlan">Beth Y. Karlan</name><affiliation><nlm:aff id="A27">Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, USA</nlm:aff></affiliation></author><author><name sortKey="Orsulic, Sandra" sort="Orsulic, Sandra" uniqKey="Orsulic S" first="Sandra" last="Orsulic">Sandra Orsulic</name><affiliation><nlm:aff id="A27">Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, USA</nlm:aff></affiliation></author><author><name sortKey="Lester, Jenny" sort="Lester, Jenny" uniqKey="Lester J" first="Jenny" last="Lester">Jenny Lester</name><affiliation><nlm:aff id="A27">Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, USA</nlm:aff></affiliation></author><author><name sortKey="Chung, Wendy K" sort="Chung, Wendy K" uniqKey="Chung W" first="Wendy K." last="Chung">Wendy K. Chung</name><affiliation><nlm:aff id="A28">Departments of Pediatrics and Medicine, Columbia University, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Miron, Alex" sort="Miron, Alex" uniqKey="Miron A" first="Alex" last="Miron">Alex Miron</name><affiliation><nlm:aff id="A29">Department of Genetics and Genomics at Case Western Reserve Medical School, Cleveland, Ohio, USA</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="A30">Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Australia</nlm:aff></affiliation></author><author><name sortKey="Goldgar, David E" sort="Goldgar, David E" uniqKey="Goldgar D" first="David E." last="Goldgar">David E. Goldgar</name><affiliation><nlm:aff id="A31">Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, USA</nlm:aff></affiliation></author><author><name sortKey="Buys, Saundra S" sort="Buys, Saundra S" uniqKey="Buys S" first="Saundra S." last="Buys">Saundra S. Buys</name><affiliation><nlm:aff id="A32">Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, USA</nlm:aff></affiliation></author><author><name sortKey="Janavicius, Ramunas" sort="Janavicius, Ramunas" uniqKey="Janavicius R" first="Ramunas" last="Janavicius">Ramunas Janavicius</name><affiliation><nlm:aff id="A33">Vilnius University Hospital Santariskiu Clinics, Hematology, Oncology and Transfusion Medicine Center, Dept. of Molecular and Regenerative Medicine; State Research Institute Centre for Innovative medicine, Vilnius, Lithuania</nlm:aff></affiliation></author><author><name sortKey="Dorfling, Cecilia M" sort="Dorfling, Cecilia M" uniqKey="Dorfling C" first="Cecilia M." last="Dorfling">Cecilia M. Dorfling</name><affiliation><nlm:aff id="A34">Department of Genetics, University of Pretoria, Pretoria, South Africa</nlm:aff></affiliation></author><author><name sortKey="Van Rensburg, Elizabeth J" sort="Van Rensburg, Elizabeth J" uniqKey="Van Rensburg E" first="Elizabeth J." last="Van Rensburg">Elizabeth J. Van Rensburg</name><affiliation><nlm:aff id="A34">Department of Genetics, University of Pretoria, Pretoria, South Africa</nlm:aff></affiliation></author><author><name sortKey="Ding, Yuan Chun" sort="Ding, Yuan Chun" uniqKey="Ding Y" first="Yuan Chun" last="Ding">Yuan Chun Ding</name><affiliation><nlm:aff id="A35">Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name><affiliation><nlm:aff id="A35">Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Hansen, Thomas V O" sort="Hansen, Thomas V O" uniqKey="Hansen T" first="Thomas V. O." last="Hansen">Thomas V. O. Hansen</name><affiliation><nlm:aff id="A36">Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Gerdes, Anne Marie" sort="Gerdes, Anne Marie" uniqKey="Gerdes A" first="Anne-Marie" last="Gerdes">Anne-Marie Gerdes</name><affiliation><nlm:aff id="A37">Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Ejlertsen, Bent" sort="Ejlertsen, Bent" uniqKey="Ejlertsen B" first="Bent" last="Ejlertsen">Bent Ejlertsen</name><affiliation><nlm:aff id="A38">Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="J Nson, Lars" sort="J Nson, Lars" uniqKey="J Nson L" first="Lars" last="J Nson">Lars J Nson</name><affiliation><nlm:aff id="A36">Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Osorio, Ana" sort="Osorio, Ana" uniqKey="Osorio A" first="Ana" last="Osorio">Ana Osorio</name><affiliation><nlm:aff id="A39">Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Martinez Bouzas, Cristina" sort="Martinez Bouzas, Cristina" uniqKey="Martinez Bouzas C" first="Cristina" last="Martínez-Bouzas">Cristina Martínez-Bouzas</name><affiliation><nlm:aff id="A41">Molecular Genetics Laboratory, Department of Biochemistry, Cruces Hospital Barakaldo, 48903-Barakaldo-Bizkaia, Spain</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation><nlm:aff id="A39">Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A42">Human Genetics Group and Genotyping Unit, Spanish National Cancer Centre (CNIO), Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Conway, Edye E" sort="Conway, Edye E" uniqKey="Conway E" first="Edye E." last="Conway">Edye E. Conway</name><affiliation><nlm:aff id="A43">Saint Alphonsus Regional Medical Center, care of City of Hope Clinical Cancer Genetics Community Research Network, Duarte, California 91010, USA</nlm:aff></affiliation></author><author><name sortKey="Blazer, Kathleen R" sort="Blazer, Kathleen R" uniqKey="Blazer K" first="Kathleen R." last="Blazer">Kathleen R. Blazer</name><affiliation><nlm:aff id="A44">Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, California 91010 USA</nlm:aff></affiliation></author><author><name sortKey="Weitzel, Jeffrey N" sort="Weitzel, Jeffrey N" uniqKey="Weitzel J" first="Jeffrey N." last="Weitzel">Jeffrey N. Weitzel</name><affiliation><nlm:aff id="A45">Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, California 91010 USA (for the City of Hope Clinical Cancer Genetics Community Research Network)</nlm:aff></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation><nlm:aff id="A46">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Peissel, Bernard" sort="Peissel, Bernard" uniqKey="Peissel B" first="Bernard" last="Peissel">Bernard Peissel</name><affiliation><nlm:aff id="A46">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Zaffaroni, Daniela" sort="Zaffaroni, Daniela" uniqKey="Zaffaroni D" first="Daniela" last="Zaffaroni">Daniela Zaffaroni</name><affiliation><nlm:aff id="A46">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Scuvera, Giulietta" sort="Scuvera, Giulietta" uniqKey="Scuvera G" first="Giulietta" last="Scuvera">Giulietta Scuvera</name><affiliation><nlm:aff id="A46">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Barile, Monica" sort="Barile, Monica" uniqKey="Barile M" first="Monica" last="Barile">Monica Barile</name><affiliation><nlm:aff id="A47">Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Ficarazzi, Filomena" sort="Ficarazzi, Filomena" uniqKey="Ficarazzi F" first="Filomena" last="Ficarazzi">Filomena Ficarazzi</name><affiliation><nlm:aff id="A1">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Cogentech Cancer Genetic Test Laboratory, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Mariette, Frederique" sort="Mariette, Frederique" uniqKey="Mariette F" first="Frederique" last="Mariette">Frederique Mariette</name><affiliation><nlm:aff id="A1">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Cogentech Cancer Genetic Test Laboratory, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Fortuzzi, Stefano" sort="Fortuzzi, Stefano" uniqKey="Fortuzzi S" first="Stefano" last="Fortuzzi">Stefano Fortuzzi</name><affiliation><nlm:aff id="A1">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Cogentech Cancer Genetic Test Laboratory, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Viel, Alessandra" sort="Viel, Alessandra" uniqKey="Viel A" first="Alessandra" last="Viel">Alessandra Viel</name><affiliation><nlm:aff id="A49">Division of Experimental Oncology 1, CRO Aviano National Cancer Institute, Aviano (PN), Italy</nlm:aff></affiliation></author><author><name sortKey="Giannini, Giuseppe" sort="Giannini, Giuseppe" uniqKey="Giannini G" first="Giuseppe" last="Giannini">Giuseppe Giannini</name><affiliation><nlm:aff id="A50">Department of Molecular Medicine, Sapienza University, Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Papi, Laura" sort="Papi, Laura" uniqKey="Papi L" first="Laura" last="Papi">Laura Papi</name><affiliation><nlm:aff id="A51">Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Martayan, Aline" sort="Martayan, Aline" uniqKey="Martayan A" first="Aline" last="Martayan">Aline Martayan</name><affiliation><nlm:aff id="A52">Unit of Genetic Counseling, Medical Oncology Department, Istituto Nazionale Tumori Regina Elena, Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Tibiletti, Maria Grazia" sort="Tibiletti, Maria Grazia" uniqKey="Tibiletti M" first="Maria Grazia" last="Tibiletti">Maria Grazia Tibiletti</name><affiliation><nlm:aff id="A53">UO Anatomia Patologica, Ospedale di Circolo e Fondazione Macchi, Polo Universitario, Varese, Italy</nlm:aff></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><nlm:aff id="A46">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Vratimos, Athanassios" sort="Vratimos, Athanassios" uniqKey="Vratimos A" first="Athanassios" last="Vratimos">Athanassios Vratimos</name><affiliation><nlm:aff id="A54">Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research “Demokritos”, Aghia Paraskevi Attikis, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Fostira, Florentia" sort="Fostira, Florentia" uniqKey="Fostira F" first="Florentia" last="Fostira">Florentia Fostira</name><affiliation><nlm:aff id="A54">Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research “Demokritos”, Aghia Paraskevi Attikis, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Garber, Judy E" sort="Garber, Judy E" uniqKey="Garber J" first="Judy E." last="Garber">Judy E. Garber</name><affiliation><nlm:aff id="A55">Dana-Farber Cancer Institute, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Donaldson, Alan" sort="Donaldson, Alan" uniqKey="Donaldson A" first="Alan" last="Donaldson">Alan Donaldson</name><affiliation><nlm:aff id="A56">Clinical Genetics Department, St Michael’s Hospital, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Brewer, Carole" sort="Brewer, Carole" uniqKey="Brewer C" first="Carole" last="Brewer">Carole Brewer</name><affiliation><nlm:aff id="A57">Department of Clinical Genetics, Royal Devon & Exeter Hospital, Exeter, UK</nlm:aff></affiliation></author><author><name sortKey="Foo, Claire" sort="Foo, Claire" uniqKey="Foo C" first="Claire" last="Foo">Claire Foo</name><affiliation><nlm:aff id="A58">Cheshire & Merseyside Clinical Genetics Service, Liverpool Women’s NHS Foundation Trust, Liverpool, UK</nlm:aff></affiliation></author><author><name sortKey="Evans, D Gareth R" sort="Evans, D Gareth R" uniqKey="Evans D" first="D. Gareth R." last="Evans">D. Gareth R. Evans</name><affiliation><nlm:aff id="A59">Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK</nlm:aff></affiliation></author><author><name sortKey="Frost, Debra" sort="Frost, Debra" uniqKey="Frost D" first="Debra" last="Frost">Debra Frost</name><affiliation><nlm:aff id="A10">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Eccles, Diana" sort="Eccles, Diana" uniqKey="Eccles D" first="Diana" last="Eccles">Diana Eccles</name><affiliation><nlm:aff id="A60">University of Southampton, Faculty of Medicine, Southampton University Hospitals NHS Trust, Southampton, UK</nlm:aff></affiliation></author><author><name sortKey="Brady, Angela" sort="Brady, Angela" uniqKey="Brady A" first="Angela" last="Brady">Angela Brady</name><affiliation><nlm:aff id="A61">North West Thames Regional Genetics Service, Kennedy-Galton Centre, Harrow, UK</nlm:aff></affiliation></author><author><name sortKey="Cook, Jackie" sort="Cook, Jackie" uniqKey="Cook J" first="Jackie" last="Cook">Jackie Cook</name><affiliation><nlm:aff id="A62">Sheffield Clinical Genetics Service, Sheffield Children’s Hospital, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Tischkowitz, Marc" sort="Tischkowitz, Marc" uniqKey="Tischkowitz M" first="Marc" last="Tischkowitz">Marc Tischkowitz</name><affiliation><nlm:aff id="A63">Department of Clinical Genetics, East Anglian Regional Genetics Service, Addenbrookes Hospital, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Adlard, Julian" sort="Adlard, Julian" uniqKey="Adlard J" first="Julian" last="Adlard">Julian Adlard</name><affiliation><nlm:aff id="A64">Yorkshire Regional Genetics Service, Leeds, UK</nlm:aff></affiliation></author><author><name sortKey="Barwell, Julian" sort="Barwell, Julian" uniqKey="Barwell J" first="Julian" last="Barwell">Julian Barwell</name><affiliation><nlm:aff id="A65">Leicestershire Clinical Genetics Service, University Hospitals of Leicester NHS Trust, UK</nlm:aff></affiliation></author><author><name sortKey="Walker, Lisa" sort="Walker, Lisa" uniqKey="Walker L" first="Lisa" last="Walker">Lisa Walker</name><affiliation><nlm:aff id="A66">Oxford Regional Genetics Service, Churchill Hospital, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Izatt, Louise" sort="Izatt, Louise" uniqKey="Izatt L" first="Louise" last="Izatt">Louise Izatt</name><affiliation><nlm:aff id="A67">Clinical Genetics, Guy’s and St. Thomas’ NHS Foundation Trust, London, UK</nlm:aff></affiliation></author><author><name sortKey="Side, Lucy E" sort="Side, Lucy E" uniqKey="Side L" first="Lucy E." last="Side">Lucy E. Side</name><affiliation><nlm:aff id="A68">North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kennedy, M John" sort="Kennedy, M John" uniqKey="Kennedy M" first="M. John" last="Kennedy">M. John Kennedy</name><affiliation><nlm:aff id="A69">Academic Unit of Clinical and Molecular Oncology, Trinity College Dublin, Eire</nlm:aff></affiliation><affiliation><nlm:aff id="A70">St James’s Hospital, Dublin, Ireland</nlm:aff></affiliation></author><author><name sortKey="Rogers, Mark T" sort="Rogers, Mark T" uniqKey="Rogers M" first="Mark T." last="Rogers">Mark T. Rogers</name><affiliation><nlm:aff id="A71">All Wales Medical Genetics Services, University Hospital of Wales, Cardiff, UK</nlm:aff></affiliation></author><author><name sortKey="Porteous, Mary E" sort="Porteous, Mary E" uniqKey="Porteous M" first="Mary E." last="Porteous">Mary E. Porteous</name><affiliation><nlm:aff id="A72">South East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, UK</nlm:aff></affiliation></author><author><name sortKey="Morrison, Patrick J" sort="Morrison, Patrick J" uniqKey="Morrison P" first="Patrick J." last="Morrison">Patrick J. Morrison</name><affiliation><nlm:aff id="A73">Centre for Cancer Research and Cell Biology, Queens University of Belfast, Department of Medical Genetics, Belfast HSC Trust, Belfast, UK</nlm:aff></affiliation></author><author><name sortKey="Platte, Radka" sort="Platte, Radka" uniqKey="Platte R" first="Radka" last="Platte">Radka Platte</name><affiliation><nlm:aff id="A10">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Davidson, Rosemarie" sort="Davidson, Rosemarie" uniqKey="Davidson R" first="Rosemarie" last="Davidson">Rosemarie Davidson</name><affiliation><nlm:aff id="A74">West of Scotland Regional Genetics Service, Southern General Hospital, Glasgow</nlm:aff></affiliation></author><author><name sortKey="Hodgson, Shirley V" sort="Hodgson, Shirley V" uniqKey="Hodgson S" first="Shirley V." last="Hodgson">Shirley V. Hodgson</name><affiliation><nlm:aff id="A75">Medical Genetics Unit, St George’s, University of London, UK</nlm:aff></affiliation></author><author><name sortKey="Ellis, Steve" sort="Ellis, Steve" uniqKey="Ellis S" first="Steve" last="Ellis">Steve Ellis</name><affiliation><nlm:aff id="A10">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Cole, Trevor" sort="Cole, Trevor" uniqKey="Cole T" first="Trevor" last="Cole">Trevor Cole</name><affiliation><nlm:aff id="A76">West Midlands Regional Genetics Service, Birmingham Women’s Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK</nlm:aff></affiliation></author><author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K." last="Godwin">Andrew K. Godwin</name><affiliation><nlm:aff id="A77">Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA</nlm:aff></affiliation></author><author><name sortKey="Claes, Kathleen" sort="Claes, Kathleen" uniqKey="Claes K" first="Kathleen" last="Claes">Kathleen Claes</name><affiliation><nlm:aff id="A78">Center for Medical Genetics, Ghent University, Ghent, Belgium</nlm:aff></affiliation></author><author><name sortKey="Van Maerken, Tom" sort="Van Maerken, Tom" uniqKey="Van Maerken T" first="Tom" last="Van Maerken">Tom Van Maerken</name><affiliation><nlm:aff id="A78">Center for Medical Genetics, Ghent University, Ghent, Belgium</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="A79">Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Gehrig, Andrea" sort="Gehrig, Andrea" uniqKey="Gehrig A" first="Andrea" last="Gehrig">Andrea Gehrig</name><affiliation><nlm:aff id="A80">Institute of Human Genetics, University Würzburg, Wurzburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Sutter, Christian" sort="Sutter, Christian" uniqKey="Sutter C" first="Christian" last="Sutter">Christian Sutter</name><affiliation><nlm:aff id="A81">University Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Engel, Christoph" sort="Engel, Christoph" uniqKey="Engel C" first="Christoph" last="Engel">Christoph Engel</name><affiliation><nlm:aff id="A82">Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Niederacher, Dieter" sort="Niederacher, Dieter" uniqKey="Niederacher D" first="Dieter" last="Niederacher">Dieter Niederacher</name><affiliation><nlm:aff id="A83">University Düsseldorf, Dusseldorf, Germany</nlm:aff></affiliation></author><author><name sortKey="Steinemann, Doris" sort="Steinemann, Doris" uniqKey="Steinemann D" first="Doris" last="Steinemann">Doris Steinemann</name><affiliation><nlm:aff id="A84">Hannover Medical School, Hanover, Germany</nlm:aff></affiliation></author><author><name sortKey="Plendl, Hansjoerg" sort="Plendl, Hansjoerg" uniqKey="Plendl H" first="Hansjoerg" last="Plendl">Hansjoerg Plendl</name><affiliation><nlm:aff id="A85">Institute of Human Genetics, University Hospital of Schleswig-Holstein/University Kiel, Kiel, Germany</nlm:aff></affiliation></author><author><name sortKey="Kast, Karin" sort="Kast, Karin" uniqKey="Kast K" first="Karin" last="Kast">Karin Kast</name><affiliation><nlm:aff id="A86">Department of Gynecology and Obstetrics, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany</nlm:aff></affiliation></author><author><name sortKey="Rhiem, Kerstin" sort="Rhiem, Kerstin" uniqKey="Rhiem K" first="Kerstin" last="Rhiem">Kerstin Rhiem</name><affiliation><nlm:aff id="A5">Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A87">Center for Molecular Medicine Cologne (CMMC), University of Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Ditsch, Nina" sort="Ditsch, Nina" uniqKey="Ditsch N" first="Nina" last="Ditsch">Nina Ditsch</name><affiliation><nlm:aff id="A88">Department of Gynaecology and Obstetrics, University Munich, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Arnold, Norbert" sort="Arnold, Norbert" uniqKey="Arnold N" first="Norbert" last="Arnold">Norbert Arnold</name><affiliation><nlm:aff id="A89">Department of Gynecology and Obstetrics, University Hospital of Schleswig-Holstein/University Kiel, Kiel, Germany</nlm:aff></affiliation></author><author><name sortKey="Varon Mateeva, Raymonda" sort="Varon Mateeva, Raymonda" uniqKey="Varon Mateeva R" first="Raymonda" last="Varon-Mateeva">Raymonda Varon-Mateeva</name><affiliation><nlm:aff id="A90">Institute of Human Genetics, Charite Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Wappenschmidt, Barbara" sort="Wappenschmidt, Barbara" uniqKey="Wappenschmidt B" first="Barbara" last="Wappenschmidt">Barbara Wappenschmidt</name><affiliation><nlm:aff id="A5">Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A87">Center for Molecular Medicine Cologne (CMMC), University of Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Wang Gohrke, Shan" sort="Wang Gohrke, Shan" uniqKey="Wang Gohrke S" first="Shan" last="Wang-Gohrke">Shan Wang-Gohrke</name><affiliation><nlm:aff id="A91">Department of Gynaecology and Obstetrics, University Hospital Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Bressac De Paillerets, Brigitte" sort="Bressac De Paillerets, Brigitte" uniqKey="Bressac De Paillerets B" first="Brigitte" last="Bressac-De Paillerets">Brigitte Bressac-De Paillerets</name><affiliation><nlm:aff id="A92">INSERM U946, Fondation Jean Dausset, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A93">Service de Génétique, Institut de Cancérologie Gustave Roussy, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Buecher, Bruno" sort="Buecher, Bruno" uniqKey="Buecher B" first="Bruno" last="Buecher">Bruno Buecher</name><affiliation><nlm:aff id="A94">Institut Curie, Department of Tumour Biology, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Delnatte, Capucine" sort="Delnatte, Capucine" uniqKey="Delnatte C" first="Capucine" last="Delnatte">Capucine Delnatte</name><affiliation><nlm:aff id="A95">Centre René Gauducheau, Nantes, France</nlm:aff></affiliation></author><author><name sortKey="Houdayer, Claude" sort="Houdayer, Claude" uniqKey="Houdayer C" first="Claude" last="Houdayer">Claude Houdayer</name><affiliation><nlm:aff id="A94">Institut Curie, Department of Tumour Biology, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A96">Université Paris Descartes, Sorbonne Paris Cité, France</nlm:aff></affiliation></author><author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name><affiliation><nlm:aff id="A94">Institut Curie, Department of Tumour Biology, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A96">Université Paris Descartes, Sorbonne Paris Cité, France</nlm:aff></affiliation><affiliation><nlm:aff id="A97">Institut Curie, INSERM U830, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Damiola, Francesca" sort="Damiola, Francesca" uniqKey="Damiola F" first="Francesca" last="Damiola">Francesca Damiola</name><affiliation><nlm:aff id="A98">INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Coupier, Isabelle" sort="Coupier, Isabelle" uniqKey="Coupier I" first="Isabelle" last="Coupier">Isabelle Coupier</name><affiliation><nlm:aff id="A99">Unité d’Oncogénétique, CHU Arnaud de Villeneuve, Montpellier, France</nlm:aff></affiliation><affiliation><nlm:aff id="A100">Unité d’Oncogénétique, CRLCC Val d’Aurelle, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Barjhoux, Laure" sort="Barjhoux, Laure" uniqKey="Barjhoux L" first="Laure" last="Barjhoux">Laure Barjhoux</name><affiliation><nlm:aff id="A100">Unité d’Oncogénétique, CRLCC Val d’Aurelle, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Venat Bouvet, Laurence" sort="Venat Bouvet, Laurence" uniqKey="Venat Bouvet L" first="Laurence" last="Venat-Bouvet">Laurence Venat-Bouvet</name><affiliation><nlm:aff id="A101">Department of Medical Oncology, Centre Hospitalier Universitaire Dupuytren, Limoges, France</nlm:aff></affiliation></author><author><name sortKey="Golmard, Lisa" sort="Golmard, Lisa" uniqKey="Golmard L" first="Lisa" last="Golmard">Lisa Golmard</name><affiliation><nlm:aff id="A94">Institut Curie, Department of Tumour Biology, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Boutry Kryza, Nadia" sort="Boutry Kryza, Nadia" uniqKey="Boutry Kryza N" first="Nadia" last="Boutry-Kryza">Nadia Boutry-Kryza</name><affiliation><nlm:aff id="A102">Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon – Centre Léon Bérard, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Sinilnikova, Olga M" sort="Sinilnikova, Olga M" uniqKey="Sinilnikova O" first="Olga M." last="Sinilnikova">Olga M. Sinilnikova</name><affiliation><nlm:aff id="A98">INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="A102">Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon – Centre Léon Bérard, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Caron, Olivier" sort="Caron, Olivier" uniqKey="Caron O" first="Olivier" last="Caron">Olivier Caron</name><affiliation><nlm:aff id="A103">Consultation de Génétique, Département de Médecine, Institut de Cancérologie Gustave Roussy, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Pujol, Pascal" sort="Pujol, Pascal" uniqKey="Pujol P" first="Pascal" last="Pujol">Pascal Pujol</name><affiliation><nlm:aff id="A99">Unité d’Oncogénétique, CHU Arnaud de Villeneuve, Montpellier, France</nlm:aff></affiliation><affiliation><nlm:aff id="A104">INSERM 896, CRCM Val d’Aurelle, Montpellier, France</nlm:aff></affiliation></author><author><name sortKey="Mazoyer, Sylvie" sort="Mazoyer, Sylvie" uniqKey="Mazoyer S" first="Sylvie" last="Mazoyer">Sylvie Mazoyer</name><affiliation><nlm:aff id="A98">INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Belotti, Muriel" sort="Belotti, Muriel" uniqKey="Belotti M" first="Muriel" last="Belotti">Muriel Belotti</name><affiliation><nlm:aff id="A94">Institut Curie, Department of Tumour Biology, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Piedmonte, Marion" sort="Piedmonte, Marion" uniqKey="Piedmonte M" first="Marion" last="Piedmonte">Marion Piedmonte</name><affiliation><nlm:aff id="A106">Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Friedlander, Michael L" sort="Friedlander, Michael L" uniqKey="Friedlander M" first="Michael L." last="Friedlander">Michael L. Friedlander</name><affiliation><nlm:aff id="A107">Australia New Zealand Gynaecological Oncology Group (ANZGOG), Coordinating Centre, Camperdown, Australia</nlm:aff></affiliation></author><author><name sortKey="Rodriguez, Gustavo C" sort="Rodriguez, Gustavo C" uniqKey="Rodriguez G" first="Gustavo C." last="Rodriguez">Gustavo C. Rodriguez</name><affiliation><nlm:aff id="A108">Division of Gynecologic Oncology, NorthShore University HealthSystem, Evanston, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Copeland, Larry J" sort="Copeland, Larry J" uniqKey="Copeland L" first="Larry J" last="Copeland">Larry J. Copeland</name><affiliation><nlm:aff id="A109">Ohio State University, Department of Obstetrics and Gynecology, Hilliard, OH, USA</nlm:aff></affiliation></author><author><name sortKey="De La Hoya, Miguel" sort="De La Hoya, Miguel" uniqKey="De La Hoya M" first="Miguel" last="De La Hoya">Miguel De La Hoya</name><affiliation><nlm:aff id="A110">Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Segura, Pedro Perez" sort="Segura, Pedro Perez" uniqKey="Segura P" first="Pedro Perez" last="Segura">Pedro Perez Segura</name><affiliation><nlm:aff id="A111">Department of Oncology, Hospital Clinico San Carlos, IdISSC, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="A112">Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A113">University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff id="A114">Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Van Os, Theo A M" sort="Van Os, Theo A M" uniqKey="Van Os T" first="Theo A. M." last="Van Os">Theo A. M. Van Os</name><affiliation><nlm:aff id="A115">Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Meijers Heijboer, Hanne E J" sort="Meijers Heijboer, Hanne E J" uniqKey="Meijers Heijboer H" first="Hanne E. J." last="Meijers-Heijboer">Hanne E. J. Meijers-Heijboer</name><affiliation><nlm:aff id="A116">Department of Clinical Genetics, VU University Medical Centre, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Der Hout, Annemarie H" sort="Van Der Hout, Annemarie H" uniqKey="Van Der Hout A" first="Annemarie H." last="Van Der Hout">Annemarie H. Van Der Hout</name><affiliation><nlm:aff id="A117">Department of Genetics, University Medical Center, Groningen University, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Vreeswijk, Maaike P G" sort="Vreeswijk, Maaike P G" uniqKey="Vreeswijk M" first="Maaike P. G." last="Vreeswijk">Maaike P. G. Vreeswijk</name><affiliation><nlm:aff id="A118">Department of Human Genetics, Leiden University Medical Center (LUMC), Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hoogerbrugge, Nicoline" sort="Hoogerbrugge, Nicoline" uniqKey="Hoogerbrugge N" first="Nicoline" last="Hoogerbrugge">Nicoline Hoogerbrugge</name><affiliation><nlm:aff id="A119">Department of Human Genetics, Radboud University Medical Centre, Nijmegen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Ausems, Margreet G E M" sort="Ausems, Margreet G E M" uniqKey="Ausems M" first="Margreet G. E. M." last="Ausems">Margreet G. E. M. Ausems</name><affiliation><nlm:aff id="A120">Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Doorn, Helena C" sort="Van Doorn, Helena C" uniqKey="Van Doorn H" first="Helena C." last="Van Doorn">Helena C. Van Doorn</name><affiliation><nlm:aff id="A121">Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Erasmus University MC Cancer Institute, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Collee, J Margriet" sort="Collee, J Margriet" uniqKey="Collee J" first="J. Margriet" last="Collée">J. Margriet Collée</name><affiliation><nlm:aff id="A122">Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Olah, Edith" sort="Olah, Edith" uniqKey="Olah E" first="Edith" last="Olah">Edith Olah</name><affiliation><nlm:aff id="A123">Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary</nlm:aff></affiliation></author><author><name sortKey="Diez, Orland" sort="Diez, Orland" uniqKey="Diez O" first="Orland" last="Diez">Orland Diez</name><affiliation><nlm:aff id="A124">Oncogenetics Group, University Hospital Vall d’Hebron, Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A125">Universitat Autònoma de Barcelona, Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A126">Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A127">Vall d’Hebron Research Institute (VHIR), Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Blanco, Ignacio" sort="Blanco, Ignacio" uniqKey="Blanco I" first="Ignacio" last="Blanco">Ignacio Blanco</name><affiliation><nlm:aff id="A128">Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Lazaro, Conxi" sort="Lazaro, Conxi" uniqKey="Lazaro C" first="Conxi" last="Lazaro">Conxi Lazaro</name><affiliation><nlm:aff id="A129">Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Brunet, Joan" sort="Brunet, Joan" uniqKey="Brunet J" first="Joan" last="Brunet">Joan Brunet</name><affiliation><nlm:aff id="A130">Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI-Catalan Institute of Oncology, Girona, Spain</nlm:aff></affiliation></author><author><name sortKey="Feliubadalo, Lidia" sort="Feliubadalo, Lidia" uniqKey="Feliubadalo L" first="Lidia" last="Feliubadalo">Lidia Feliubadalo</name><affiliation><nlm:aff id="A131">BMC, Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Cybulski, Cezary" sort="Cybulski, Cezary" uniqKey="Cybulski C" first="Cezary" last="Cybulski">Cezary Cybulski</name><affiliation><nlm:aff id="A20">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Gronwald, Jacek" sort="Gronwald, Jacek" uniqKey="Gronwald J" first="Jacek" last="Gronwald">Jacek Gronwald</name><affiliation><nlm:aff id="A20">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name><affiliation><nlm:aff id="A20">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Jaworska Bieniek, Katarzyna" sort="Jaworska Bieniek, Katarzyna" uniqKey="Jaworska Bieniek K" first="Katarzyna" last="Jaworska-Bieniek">Katarzyna Jaworska-Bieniek</name><affiliation><nlm:aff id="A20">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Sukiennicki, Grzegorz" sort="Sukiennicki, Grzegorz" uniqKey="Sukiennicki G" first="Grzegorz" last="Sukiennicki">Grzegorz Sukiennicki</name><affiliation><nlm:aff id="A20">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Arason, Adalgeir" sort="Arason, Adalgeir" uniqKey="Arason A" first="Adalgeir" last="Arason">Adalgeir Arason</name><affiliation><nlm:aff id="A131">BMC, Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff></affiliation><affiliation><nlm:aff id="A132">Department of Pathology, Landspitali University Hospital, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Chiquette, Jocelyne" sort="Chiquette, Jocelyne" uniqKey="Chiquette J" first="Jocelyne" last="Chiquette">Jocelyne Chiquette</name><affiliation><nlm:aff id="A133">Unité de Recherche en Santé des Populations, Centre des Maladies du Sein Deschênes-Fabia, Centre de Recherche FRSQ du Centre Hospitalier Affilié Universitaire de Québec, Québec, QC, Canada</nlm:aff></affiliation></author><author><name sortKey="Teixeira, Manuel R" sort="Teixeira, Manuel R" uniqKey="Teixeira M" first="Manuel R." last="Teixeira">Manuel R. Teixeira</name><affiliation><nlm:aff id="A134">Biomedical Sciences Institute (ICBAS), Porto University, Porto, Portugal</nlm:aff></affiliation><affiliation><nlm:aff id="A135">Department of Genetics, Portuguese Oncology Institute, Porto, Portugal</nlm:aff></affiliation></author><author><name sortKey="Olswold, Curtis" sort="Olswold, Curtis" uniqKey="Olswold C" first="Curtis" last="Olswold">Curtis Olswold</name><affiliation><nlm:aff id="A136">Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="A137">Department of Laboratory Medicine and Pathology, and Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Lindor, Noralane M" sort="Lindor, Noralane M" uniqKey="Lindor N" first="Noralane M." last="Lindor">Noralane M. Lindor</name><affiliation><nlm:aff id="A138">Health Sciences Research, Mayo Clinic, Scottsdale, AZ, USA</nlm:aff></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation><nlm:aff id="A139">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Szabo, Csilla I" sort="Szabo, Csilla I" uniqKey="Szabo C" first="Csilla I." last="Szabo">Csilla I. Szabo</name><affiliation><nlm:aff id="A140">National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name><affiliation><nlm:aff id="A141">Clinical Genetics Research Laboratory, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Corines, Marina" sort="Corines, Marina" uniqKey="Corines M" first="Marina" last="Corines">Marina Corines</name><affiliation><nlm:aff id="A142">Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Jacobs, Lauren" sort="Jacobs, Lauren" uniqKey="Jacobs L" first="Lauren" last="Jacobs">Lauren Jacobs</name><affiliation><nlm:aff id="A142">Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Robson, Mark E" sort="Robson, Mark E" uniqKey="Robson M" first="Mark E." last="Robson">Mark E. Robson</name><affiliation><nlm:aff id="A141">Clinical Genetics Research Laboratory, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Zhang, Liying" sort="Zhang, Liying" uniqKey="Zhang L" first="Liying" last="Zhang">Liying Zhang</name><affiliation><nlm:aff id="A143">Diagnostic Molecular Genetics Laboratory, Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Joseph, Vijai" sort="Joseph, Vijai" uniqKey="Joseph V" first="Vijai" last="Joseph">Vijai Joseph</name><affiliation><nlm:aff id="A141">Clinical Genetics Research Laboratory, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Berger, Andreas" sort="Berger, Andreas" uniqKey="Berger A" first="Andreas" last="Berger">Andreas Berger</name><affiliation><nlm:aff id="A144">Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Singer, Christian F" sort="Singer, Christian F" uniqKey="Singer C" first="Christian F." last="Singer">Christian F. Singer</name><affiliation><nlm:aff id="A144">Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Rappaport, Christine" sort="Rappaport, Christine" uniqKey="Rappaport C" first="Christine" last="Rappaport">Christine Rappaport</name><affiliation><nlm:aff id="A144">Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Kaulich, Daphne Geschwantler" sort="Kaulich, Daphne Geschwantler" uniqKey="Kaulich D" first="Daphne Geschwantler" last="Kaulich">Daphne Geschwantler Kaulich</name><affiliation><nlm:aff id="A144">Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Pfeiler, Georg" sort="Pfeiler, Georg" uniqKey="Pfeiler G" first="Georg" last="Pfeiler">Georg Pfeiler</name><affiliation><nlm:aff id="A144">Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Tea, Muy Kheng M" sort="Tea, Muy Kheng M" uniqKey="Tea M" first="Muy-Kheng M." last="Tea">Muy-Kheng M. Tea</name><affiliation><nlm:aff id="A144">Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Phelan, Catherine M" sort="Phelan, Catherine M" uniqKey="Phelan C" first="Catherine M." last="Phelan">Catherine M. Phelan</name><affiliation><nlm:aff id="A145">Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA</nlm:aff></affiliation></author><author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H." last="Greene">Mark H. Greene</name><affiliation><nlm:aff id="A146">Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Mai, Phuong L" sort="Mai, Phuong L" uniqKey="Mai P" first="Phuong L." last="Mai">Phuong L. Mai</name><affiliation><nlm:aff id="A146">Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name><affiliation><nlm:aff id="A147">Clalit National Cancer Control Center, Haifa, Israel</nlm:aff></affiliation></author><author><name sortKey="Mulligan, Anna Marie" sort="Mulligan, Anna Marie" uniqKey="Mulligan A" first="Anna Marie" last="Mulligan">Anna Marie Mulligan</name><affiliation><nlm:aff id="A148">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A149">Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation><nlm:aff id="A150">Ontario Cancer Genetics Network: Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Tchatchou, Sandrine" sort="Tchatchou, Sandrine" uniqKey="Tchatchou S" first="Sandrine" last="Tchatchou">Sandrine Tchatchou</name><affiliation><nlm:aff id="A151">Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="A151">Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A152">Departments of Molecular Genetics and Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Toland, Amanda Ewart" sort="Toland, Amanda Ewart" uniqKey="Toland A" first="Amanda Ewart" last="Toland">Amanda Ewart Toland</name><affiliation><nlm:aff id="A153">Division of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Anders" sort="Bojesen, Anders" uniqKey="Bojesen A" first="Anders" last="Bojesen">Anders Bojesen</name><affiliation><nlm:aff id="A154">Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark</nlm:aff></affiliation></author><author><name sortKey="Pedersen, Inge Sokilde" sort="Pedersen, Inge Sokilde" uniqKey="Pedersen I" first="Inge Sokilde" last="Pedersen">Inge Sokilde Pedersen</name><affiliation><nlm:aff id="A155">Section of Molecular Diagnostics, Department of Biochemistry, Aalborg University Hospital, Aalborg, Denmark</nlm:aff></affiliation></author><author><name sortKey="Thomassen, Mads" sort="Thomassen, Mads" uniqKey="Thomassen M" first="Mads" last="Thomassen">Mads Thomassen</name><affiliation><nlm:aff id="A156">Department of Clinical Genetics, Odense University Hospital, Odense C, Denmark</nlm:aff></affiliation></author><author><name sortKey="Jensen, Uffe Birk" sort="Jensen, Uffe Birk" uniqKey="Jensen U" first="Uffe Birk" last="Jensen">Uffe Birk Jensen</name><affiliation><nlm:aff id="A157">Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark</nlm:aff></affiliation></author><author><name sortKey="Laitman, Yael" sort="Laitman, Yael" uniqKey="Laitman Y" first="Yael" last="Laitman">Yael Laitman</name><affiliation><nlm:aff id="A158">Sheba Medical Center, Tel Aviv, Israel</nlm:aff></affiliation></author><author><name sortKey="Rantala, Johanna" sort="Rantala, Johanna" uniqKey="Rantala J" first="Johanna" last="Rantala">Johanna Rantala</name><affiliation><nlm:aff id="A159">Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Von Wachenfeldt, Anna" sort="Von Wachenfeldt, Anna" uniqKey="Von Wachenfeldt A" first="Anna" last="Von Wachenfeldt">Anna Von Wachenfeldt</name><affiliation><nlm:aff id="A160">Department of Oncology, Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Ehrencrona, Hans" sort="Ehrencrona, Hans" uniqKey="Ehrencrona H" first="Hans" last="Ehrencrona">Hans Ehrencrona</name><affiliation><nlm:aff id="A161">Department of Clinical Genetics, Lund University Hospital, Lund, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A162">Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Askmalm, Marie Stenmark" sort="Askmalm, Marie Stenmark" uniqKey="Askmalm M" first="Marie Stenmark" last="Askmalm">Marie Stenmark Askmalm</name><affiliation><nlm:aff id="A163">Division of Clinical Genetics, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden</nlm:aff></affiliation></author><author><name sortKey="Borg, Ke" sort="Borg, Ke" uniqKey="Borg " first=" Ke" last="Borg"> Ke Borg</name><affiliation><nlm:aff id="A164">Department of Oncology, Lund University, Lund, Sweden</nlm:aff></affiliation></author><author><name sortKey="Kuchenbaecker, Karoline B" sort="Kuchenbaecker, Karoline B" uniqKey="Kuchenbaecker K" first="Karoline B." last="Kuchenbaecker">Karoline B. Kuchenbaecker</name><affiliation><nlm:aff id="A10">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name><affiliation><nlm:aff id="A10">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Barrowdale, Daniel" sort="Barrowdale, Daniel" uniqKey="Barrowdale D" first="Daniel" last="Barrowdale">Daniel Barrowdale</name><affiliation><nlm:aff id="A10">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Healey, Sue" sort="Healey, Sue" uniqKey="Healey S" first="Sue" last="Healey">Sue Healey</name><affiliation><nlm:aff id="A16">Department of Genetics and Computational Biology, QIMR Berghofer, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Lee, Andrew" sort="Lee, Andrew" uniqKey="Lee A" first="Andrew" last="Lee">Andrew Lee</name><affiliation><nlm:aff id="A10">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name><affiliation><nlm:aff id="A165">Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="A16">Department of Genetics and Computational Biology, QIMR Berghofer, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C." last="Antoniou">Antonis C. Antoniou</name><affiliation><nlm:aff id="A10">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name><affiliation><nlm:aff id="A158">Sheba Medical Center, Tel Aviv, Israel</nlm:aff></affiliation></author></analytic><series><title level="j">Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</title><idno type="ISSN">1055-9965</idno><idno type="eISSN">1538-7755</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1"><italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers are at substantially increased risk for developing breast and ovarian cancer. The incomplete penetrance coupled with the variable age at diagnosis in carriers of the same mutation suggests the existence of genetic and non-genetic modifying factors. In this study we evaluated the putative role of variants in many candidate modifier genes.</p></sec><sec id="S2"><title>Methods</title><p id="P2">Genotyping data from 15,252 <italic>BRCA1</italic> and 8,211 <italic>BRCA2</italic> mutation carriers, for known variants (n=3,248) located within or around 445 candidate genes, were available through the iCOGS custom-designed array. Breast and ovarian cancer association analysis was performed within a retrospective cohort approach.</p></sec><sec id="S3"><title>Results</title><p id="P3">The observed p-values of association ranged between 0.005-1.000. None of the variants was significantly associated with breast or ovarian cancer risk in either <italic>BRCA1</italic> or <italic>BRCA2</italic> mutation carriers, after multiple testing adjustments.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">There is little evidence that any of the evaluated candidate variants act as modifiers of breast and/or ovarian cancer risk in <italic>BRCA1</italic> or <italic>BRCA2</italic> mutation carriers.</p></sec><sec id="S5"><title>Impact</title><p id="P5">Genome-wide association studies have been more successful at identifying genetic modifiers of <italic>BRCA1/2</italic> penetrance than candidate gene studies.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9200608</journal-id><journal-id journal-id-type="pubmed-jr-id">2299</journal-id><journal-id journal-id-type="nlm-ta">Cancer Epidemiol Biomarkers Prev</journal-id><journal-id journal-id-type="iso-abbrev">Cancer Epidemiol. Biomarkers Prev.</journal-id><journal-title-group><journal-title>Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</journal-title></journal-title-group><issn pub-type="ppub">1055-9965</issn><issn pub-type="epub">1538-7755</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25336561</article-id><article-id pub-id-type="pmc">4294951</article-id><article-id pub-id-type="doi">10.1158/1055-9965.EPI-14-0532</article-id><article-id pub-id-type="manuscript">EMS60680</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Candidate genetic modifiers for breast and ovarian cancer risk in <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers</article-title></title-group><contrib-group><contrib 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contrib-type="author"><name><surname>Zhang</surname><given-names>Liying</given-names></name><xref ref-type="aff" rid="A143">143</xref></contrib><contrib contrib-type="author"><name><surname>Joseph</surname><given-names>Vijai</given-names></name><xref ref-type="aff" rid="A141">141</xref></contrib><contrib contrib-type="author"><name><surname>Berger</surname><given-names>Andreas</given-names></name><xref ref-type="aff" rid="A144">144</xref></contrib><contrib contrib-type="author"><name><surname>Singer</surname><given-names>Christian F.</given-names></name><xref ref-type="aff" rid="A144">144</xref></contrib><contrib contrib-type="author"><name><surname>Rappaport</surname><given-names>Christine</given-names></name><xref ref-type="aff" rid="A144">144</xref></contrib><contrib contrib-type="author"><name><surname>Kaulich</surname><given-names>Daphne Geschwantler</given-names></name><xref ref-type="aff" rid="A144">144</xref></contrib><contrib contrib-type="author"><name><surname>Pfeiler</surname><given-names>Georg</given-names></name><xref ref-type="aff" rid="A144">144</xref></contrib><contrib contrib-type="author"><name><surname>Tea</surname><given-names>Muy-Kheng M.</given-names></name><xref ref-type="aff" rid="A144">144</xref></contrib><contrib contrib-type="author"><name><surname>Phelan</surname><given-names>Catherine M.</given-names></name><xref ref-type="aff" rid="A145">145</xref></contrib><contrib contrib-type="author"><name><surname>Greene</surname><given-names>Mark H.</given-names></name><xref ref-type="aff" rid="A146">146</xref></contrib><contrib contrib-type="author"><name><surname>Mai</surname><given-names>Phuong L.</given-names></name><xref ref-type="aff" rid="A146">146</xref></contrib><contrib contrib-type="author"><name><surname>Rennert</surname><given-names>Gad</given-names></name><xref ref-type="aff" rid="A147">147</xref></contrib><contrib contrib-type="author"><name><surname>Mulligan</surname><given-names>Anna Marie</given-names></name><xref ref-type="aff" rid="A148">148</xref><xref ref-type="aff" rid="A149">149</xref></contrib><contrib contrib-type="author"><name><surname>Glendon</surname><given-names>Gord</given-names></name><xref ref-type="aff" rid="A150">150</xref></contrib><contrib contrib-type="author"><name><surname>Tchatchou</surname><given-names>Sandrine</given-names></name><xref ref-type="aff" rid="A151">151</xref></contrib><contrib contrib-type="author"><name><surname>Andrulis</surname><given-names>Irene L.</given-names></name><xref ref-type="aff" rid="A151">151</xref><xref ref-type="aff" rid="A152">152</xref></contrib><contrib contrib-type="author"><name><surname>Toland</surname><given-names>Amanda Ewart</given-names></name><xref ref-type="aff" rid="A153">153</xref></contrib><contrib contrib-type="author"><name><surname>Bojesen</surname><given-names>Anders</given-names></name><xref ref-type="aff" rid="A154">154</xref></contrib><contrib contrib-type="author"><name><surname>Pedersen</surname><given-names>Inge Sokilde</given-names></name><xref ref-type="aff" rid="A155">155</xref></contrib><contrib contrib-type="author"><name><surname>Thomassen</surname><given-names>Mads</given-names></name><xref ref-type="aff" rid="A156">156</xref></contrib><contrib contrib-type="author"><name><surname>Jensen</surname><given-names>Uffe Birk</given-names></name><xref ref-type="aff" rid="A157">157</xref></contrib><contrib contrib-type="author"><name><surname>Laitman</surname><given-names>Yael</given-names></name><xref ref-type="aff" rid="A158">158</xref></contrib><contrib contrib-type="author"><name><surname>Rantala</surname><given-names>Johanna</given-names></name><xref ref-type="aff" rid="A159">159</xref></contrib><contrib contrib-type="author"><name><surname>von Wachenfeldt</surname><given-names>Anna</given-names></name><xref ref-type="aff" rid="A160">160</xref></contrib><contrib contrib-type="author"><name><surname>Ehrencrona</surname><given-names>Hans</given-names></name><xref ref-type="aff" rid="A161">161</xref><xref ref-type="aff" rid="A162">162</xref></contrib><contrib contrib-type="author"><name><surname>Askmalm</surname><given-names>Marie Stenmark</given-names></name><xref ref-type="aff" rid="A163">163</xref></contrib><contrib contrib-type="author"><name><surname>Borg</surname><given-names>Åke</given-names></name><xref ref-type="aff" rid="A164">164</xref></contrib><contrib contrib-type="author"><name><surname>Kuchenbaecker</surname><given-names>Karoline B.</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>McGuffog</surname><given-names>Lesley</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Barrowdale</surname><given-names>Daniel</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Healey</surname><given-names>Sue</given-names></name><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Andrew</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Pharoah</surname><given-names>Paul D.P.</given-names></name><xref ref-type="aff" rid="A165">165</xref></contrib><contrib contrib-type="author"><name><surname>Chenevix-Trench</surname><given-names>Georgia</given-names></name><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><collab>on behalf of KConFab Investigators</collab><xref ref-type="aff" rid="A166">166</xref></contrib><contrib contrib-type="author"><name><surname>Antoniou</surname><given-names>Antonis C.</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Friedman</surname><given-names>Eitan</given-names></name><xref ref-type="aff" rid="A158">158</xref></contrib></contrib-group><aff id="A1"><label>1</label>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</aff><aff id="A2"><label>2</label>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</aff><aff id="A3"><label>3</label>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="A4"><label>4</label>Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA</aff><aff id="A5"><label>5</label>Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne, Germany</aff><aff id="A6"><label>6</label>Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Germany</aff><aff id="A7"><label>7</label>Center for Molecular Medicine Cologne (CMMC), University of Cologne, Germany, on behalf of the German Consortium of Hereditary Breast and Ovarian Cancer (GC-HBOC)</aff><aff id="A8"><label>8</label>Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City, Canada</aff><aff id="A9"><label>9</label>Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, UK</aff><aff id="A10"><label>10</label>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK</aff><aff id="A11"><label>11</label>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="A12"><label>12</label>Genomic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="A13"><label>13</label>Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="A14"><label>14</label>Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</aff><aff id="A15"><label>15</label>Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands</aff><aff id="A16"><label>16</label>Department of Genetics and Computational Biology, QIMR Berghofer, Brisbane, Australia</aff><aff id="A17"><label>17</label>Department of Pathology, University of Otago, Christchurch, New Zealand</aff><aff id="A18"><label>18</label>Department of Biomedical Sciences and Medicine, Gambelas Campus, University of Algarve, Portugal</aff><aff id="A19"><label>19</label>Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS, Padua, Italy</aff><aff id="A20"><label>20</label>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</aff><aff id="A21"><label>21</label>Department of Clinical Genetics, MUMC, Maastricht, The Netherlands</aff><aff id="A22"><label>22</label>Center for Clinical Cancer Genetic, Department of Medicine and Human Genetics, University of Chicago Medical Center, Chicago, USA</aff><aff id="A23"><label>23</label>Department of Medicine and Institute for Human Genetics, University of California, San Francisco, USA</aff><aff id="A24"><label>24</label>Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, USA</aff><aff id="A25"><label>25</label>Department of Epidemiology and Biostatistics, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, USA</aff><aff id="A26"><label>26</label>University of Texas MD Anderson Cancer Center, Houston, TX, USA</aff><aff id="A27"><label>27</label>Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, USA</aff><aff id="A28"><label>28</label>Departments of Pediatrics and Medicine, Columbia University, New York, NY, USA</aff><aff id="A29"><label>29</label>Department of Genetics and Genomics at Case Western Reserve Medical School, Cleveland, Ohio, USA</aff><aff id="A30"><label>30</label>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Australia</aff><aff id="A31"><label>31</label>Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, USA</aff><aff id="A32"><label>32</label>Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, USA</aff><aff id="A33"><label>33</label>Vilnius University Hospital Santariskiu Clinics, Hematology, Oncology and Transfusion Medicine Center, Dept. of Molecular and Regenerative Medicine; State Research Institute Centre for Innovative medicine, Vilnius, Lithuania</aff><aff id="A34"><label>34</label>Department of Genetics, University of Pretoria, Pretoria, South Africa</aff><aff id="A35"><label>35</label>Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA</aff><aff id="A36"><label>36</label>Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</aff><aff id="A37"><label>37</label>Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</aff><aff id="A38"><label>38</label>Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</aff><aff id="A39"><label>39</label>Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain</aff><aff id="A40"><label>40</label>Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain</aff><aff id="A41"><label>41</label>Molecular Genetics Laboratory, Department of Biochemistry, Cruces Hospital Barakaldo, 48903-Barakaldo-Bizkaia, Spain</aff><aff id="A42"><label>42</label>Human Genetics Group and Genotyping Unit, Spanish National Cancer Centre (CNIO), Madrid, Spain</aff><aff id="A43"><label>43</label>Saint Alphonsus Regional Medical Center, care of City of Hope Clinical Cancer Genetics Community Research Network, Duarte, California 91010, USA</aff><aff id="A44"><label>44</label>Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, California 91010 USA</aff><aff id="A45"><label>45</label>Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, California 91010 USA (for the City of Hope Clinical Cancer Genetics Community Research Network)</aff><aff id="A46"><label>46</label>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</aff><aff id="A47"><label>47</label>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy</aff><aff id="A48"><label>48</label>Cogentech Cancer Genetic Test Laboratory, Milan, Italy</aff><aff id="A49"><label>49</label>Division of Experimental Oncology 1, CRO Aviano National Cancer Institute, Aviano (PN), Italy</aff><aff id="A50"><label>50</label>Department of Molecular Medicine, Sapienza University, Rome, Italy</aff><aff id="A51"><label>51</label>Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy</aff><aff id="A52"><label>52</label>Unit of Genetic Counseling, Medical Oncology Department, Istituto Nazionale Tumori Regina Elena, Rome, Italy</aff><aff id="A53"><label>53</label>UO Anatomia Patologica, Ospedale di Circolo e Fondazione Macchi, Polo Universitario, Varese, Italy</aff><aff id="A54"><label>54</label>Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research “Demokritos”, Aghia Paraskevi Attikis, Athens, Greece</aff><aff id="A55"><label>55</label>Dana-Farber Cancer Institute, Boston, MA, USA</aff><aff id="A56"><label>56</label>Clinical Genetics Department, St Michael’s Hospital, Bristol, UK</aff><aff id="A57"><label>57</label>Department of Clinical Genetics, Royal Devon & Exeter Hospital, Exeter, UK</aff><aff id="A58"><label>58</label>Cheshire & Merseyside Clinical Genetics Service, Liverpool Women’s NHS Foundation Trust, Liverpool, UK</aff><aff id="A59"><label>59</label>Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK</aff><aff id="A60"><label>60</label>University of Southampton, Faculty of Medicine, Southampton University Hospitals NHS Trust, Southampton, UK</aff><aff id="A61"><label>61</label>North West Thames Regional Genetics Service, Kennedy-Galton Centre, Harrow, UK</aff><aff id="A62"><label>62</label>Sheffield Clinical Genetics Service, Sheffield Children’s Hospital, Sheffield, UK</aff><aff id="A63"><label>63</label>Department of Clinical Genetics, East Anglian Regional Genetics Service, Addenbrookes Hospital, Cambridge, UK</aff><aff id="A64"><label>64</label>Yorkshire Regional Genetics Service, Leeds, UK</aff><aff id="A65"><label>65</label>Leicestershire Clinical Genetics Service, University Hospitals of Leicester NHS Trust, UK</aff><aff id="A66"><label>66</label>Oxford Regional Genetics Service, Churchill Hospital, Oxford, UK</aff><aff id="A67"><label>67</label>Clinical Genetics, Guy’s and St. Thomas’ NHS Foundation Trust, London, UK</aff><aff id="A68"><label>68</label>North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, London, UK</aff><aff id="A69"><label>69</label>Academic Unit of Clinical and Molecular Oncology, Trinity College Dublin, Eire</aff><aff id="A70"><label>70</label>St James’s Hospital, Dublin, Ireland</aff><aff id="A71"><label>71</label>All Wales Medical Genetics Services, University Hospital of Wales, Cardiff, UK</aff><aff id="A72"><label>72</label>South East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, UK</aff><aff id="A73"><label>73</label>Centre for Cancer Research and Cell Biology, Queens University of Belfast, Department of Medical Genetics, Belfast HSC Trust, Belfast, UK</aff><aff id="A74"><label>74</label>West of Scotland Regional Genetics Service, Southern General Hospital, Glasgow</aff><aff id="A75"><label>75</label>Medical Genetics Unit, St George’s, University of London, UK</aff><aff id="A76"><label>76</label>West Midlands Regional Genetics Service, Birmingham Women’s Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK</aff><aff id="A77"><label>77</label>Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA</aff><aff id="A78"><label>78</label>Center for Medical Genetics, Ghent University, Ghent, Belgium</aff><aff id="A79"><label>79</label>Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Germany</aff><aff id="A80"><label>80</label>Institute of Human Genetics, University Würzburg, Wurzburg, Germany</aff><aff id="A81"><label>81</label>University Heidelberg, Heidelberg, Germany</aff><aff id="A82"><label>82</label>Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany</aff><aff id="A83"><label>83</label>University Düsseldorf, Dusseldorf, Germany</aff><aff id="A84"><label>84</label>Hannover Medical School, Hanover, Germany</aff><aff id="A85"><label>85</label>Institute of Human Genetics, University Hospital of Schleswig-Holstein/University Kiel, Kiel, Germany</aff><aff id="A86"><label>86</label>Department of Gynecology and Obstetrics, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany</aff><aff id="A87"><label>87</label>Center for Molecular Medicine Cologne (CMMC), University of Cologne, Germany</aff><aff id="A88"><label>88</label>Department of Gynaecology and Obstetrics, University Munich, Munich, Germany</aff><aff id="A89"><label>89</label>Department of Gynecology and Obstetrics, University Hospital of Schleswig-Holstein/University Kiel, Kiel, Germany</aff><aff id="A90"><label>90</label>Institute of Human Genetics, Charite Berlin, Germany</aff><aff id="A91"><label>91</label>Department of Gynaecology and Obstetrics, University Hospital Ulm, Germany</aff><aff id="A92"><label>92</label>INSERM U946, Fondation Jean Dausset, Paris, France</aff><aff id="A93"><label>93</label>Service de Génétique, Institut de Cancérologie Gustave Roussy, Villejuif, France</aff><aff id="A94"><label>94</label>Institut Curie, Department of Tumour Biology, Paris, France</aff><aff id="A95"><label>95</label>Centre René Gauducheau, Nantes, France</aff><aff id="A96"><label>96</label>Université Paris Descartes, Sorbonne Paris Cité, France</aff><aff id="A97"><label>97</label>Institut Curie, INSERM U830, Paris, France</aff><aff id="A98"><label>98</label>INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France</aff><aff id="A99"><label>99</label>Unité d’Oncogénétique, CHU Arnaud de Villeneuve, Montpellier, France</aff><aff id="A100"><label>100</label>Unité d’Oncogénétique, CRLCC Val d’Aurelle, Montpellier, France</aff><aff id="A101"><label>101</label>Department of Medical Oncology, Centre Hospitalier Universitaire Dupuytren, Limoges, France</aff><aff id="A102"><label>102</label>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon – Centre Léon Bérard, Lyon, France</aff><aff id="A103"><label>103</label>Consultation de Génétique, Département de Médecine, Institut de Cancérologie Gustave Roussy, Villejuif, France</aff><aff id="A104"><label>104</label>INSERM 896, CRCM Val d’Aurelle, Montpellier, France</aff><aff id="A105"><label>105</label>GEMO study: National Cancer Genetics Network «UNICANCER Genetic Grou», France</aff><aff id="A106"><label>106</label>Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, NY, USA</aff><aff id="A107"><label>107</label>Australia New Zealand Gynaecological Oncology Group (ANZGOG), Coordinating Centre, Camperdown, Australia</aff><aff id="A108"><label>108</label>Division of Gynecologic Oncology, NorthShore University HealthSystem, Evanston, IL, USA</aff><aff id="A109"><label>109</label>Ohio State University, Department of Obstetrics and Gynecology, Hilliard, OH, USA</aff><aff id="A110"><label>110</label>Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC, Madrid, Spain</aff><aff id="A111"><label>111</label>Department of Oncology, Hospital Clinico San Carlos, IdISSC, Madrid, Spain</aff><aff id="A112"><label>112</label>Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland</aff><aff id="A113"><label>113</label>University of Helsinki, Helsinki, Finland</aff><aff id="A114"><label>114</label>Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland</aff><aff id="A115"><label>115</label>Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands</aff><aff id="A116"><label>116</label>Department of Clinical Genetics, VU University Medical Centre, Amsterdam, The Netherlands</aff><aff id="A117"><label>117</label>Department of Genetics, University Medical Center, Groningen University, Groningen, The Netherlands</aff><aff id="A118"><label>118</label>Department of Human Genetics, Leiden University Medical Center (LUMC), Leiden, The Netherlands</aff><aff id="A119"><label>119</label>Department of Human Genetics, Radboud University Medical Centre, Nijmegen, The Netherlands</aff><aff id="A120"><label>120</label>Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</aff><aff id="A121"><label>121</label>Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Erasmus University MC Cancer Institute, Rotterdam, The Netherlands</aff><aff id="A122"><label>122</label>Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</aff><aff id="A123"><label>123</label>Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary</aff><aff id="A124"><label>124</label>Oncogenetics Group, University Hospital Vall d’Hebron, Barcelona, Spain</aff><aff id="A125"><label>125</label>Universitat Autònoma de Barcelona, Barcelona, Spain</aff><aff id="A126"><label>126</label>Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain</aff><aff id="A127"><label>127</label>Vall d’Hebron Research Institute (VHIR), Barcelona, Spain</aff><aff id="A128"><label>128</label>Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain</aff><aff id="A129"><label>129</label>Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain</aff><aff id="A130"><label>130</label>Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI-Catalan Institute of Oncology, Girona, Spain</aff><aff id="A131"><label>131</label>BMC, Faculty of Medicine, University of Iceland, Reykjavik, Iceland</aff><aff id="A132"><label>132</label>Department of Pathology, Landspitali University Hospital, Reykjavik, Iceland</aff><aff id="A133"><label>133</label>Unité de Recherche en Santé des Populations, Centre des Maladies du Sein Deschênes-Fabia, Centre de Recherche FRSQ du Centre Hospitalier Affilié Universitaire de Québec, Québec, QC, Canada</aff><aff id="A134"><label>134</label>Biomedical Sciences Institute (ICBAS), Porto University, Porto, Portugal</aff><aff id="A135"><label>135</label>Department of Genetics, Portuguese Oncology Institute, Porto, Portugal</aff><aff id="A136"><label>136</label>Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</aff><aff id="A137"><label>137</label>Department of Laboratory Medicine and Pathology, and Health Sciences Research, Mayo Clinic, Rochester, MN, USA</aff><aff id="A138"><label>138</label>Health Sciences Research, Mayo Clinic, Scottsdale, AZ, USA</aff><aff id="A139"><label>139</label>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA</aff><aff id="A140"><label>140</label>National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA</aff><aff id="A141"><label>141</label>Clinical Genetics Research Laboratory, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</aff><aff id="A142"><label>142</label>Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</aff><aff id="A143"><label>143</label>Diagnostic Molecular Genetics Laboratory, Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</aff><aff id="A144"><label>144</label>Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</aff><aff id="A145"><label>145</label>Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA</aff><aff id="A146"><label>146</label>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA</aff><aff id="A147"><label>147</label>Clalit National Cancer Control Center, Haifa, Israel</aff><aff id="A148"><label>148</label>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada</aff><aff id="A149"><label>149</label>Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada</aff><aff id="A150"><label>150</label>Ontario Cancer Genetics Network: Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</aff><aff id="A151"><label>151</label>Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</aff><aff id="A152"><label>152</label>Departments of Molecular Genetics and Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada</aff><aff id="A153"><label>153</label>Division of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA</aff><aff id="A154"><label>154</label>Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark</aff><aff id="A155"><label>155</label>Section of Molecular Diagnostics, Department of Biochemistry, Aalborg University Hospital, Aalborg, Denmark</aff><aff id="A156"><label>156</label>Department of Clinical Genetics, Odense University Hospital, Odense C, Denmark</aff><aff id="A157"><label>157</label>Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark</aff><aff id="A158"><label>158</label>Sheba Medical Center, Tel Aviv, Israel</aff><aff id="A159"><label>159</label>Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden</aff><aff id="A160"><label>160</label>Department of Oncology, Karolinska University Hospital, Stockholm, Sweden</aff><aff id="A161"><label>161</label>Department of Clinical Genetics, Lund University Hospital, Lund, Sweden</aff><aff id="A162"><label>162</label>Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden</aff><aff id="A163"><label>163</label>Division of Clinical Genetics, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden</aff><aff id="A164"><label>164</label>Department of Oncology, Lund University, Lund, Sweden</aff><aff id="A165"><label>165</label>Department of Oncology, University of Cambridge, Cambridge, UK</aff><aff id="A166"><label>166</label>kConFab: Kathleen Cuningham Consortium for Research into Familial Breast Cancer – Peter MacCallum Cancer Center, Melbourne, Australia</aff><author-notes><corresp id="CR1"><bold>Corresponding authors</bold>: Paolo Peterlongo, PhD, IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139, Milan, Italy, Tel +39.02.57430.3812; fax: +39.02.57430.3231; <email>paolo.peterlongo@ifom.eu</email>; Eitan Friedman, MD PhD, The Susanne-Levy Gertner Oncogenetics Unit, The Danek Gertner Institute of Genetics, Chaim Sheba Medical Center, Tel-Hashomer, 52621, Israel, Tel: 972-3-530-3173; fax: 972-3-535-7308; <email>eitan.friedman@sheba.health.gov.il</email> or, <email>feitan@post.tau.ac.il</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>24</day><month>10</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>21</day><month>10</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>1</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>7</month><year>2015</year></pub-date><volume>24</volume><issue>1</issue><fpage>308</fpage><lpage>316</lpage><pmc-comment>elocation-id from pubmed: 10.1158/1055-9965.EPI-14-0532</pmc-comment>
<abstract><sec id="S1"><title>Background</title><p id="P1"><italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers are at substantially increased risk for developing breast and ovarian cancer. The incomplete penetrance coupled with the variable age at diagnosis in carriers of the same mutation suggests the existence of genetic and non-genetic modifying factors. In this study we evaluated the putative role of variants in many candidate modifier genes.</p></sec><sec id="S2"><title>Methods</title><p id="P2">Genotyping data from 15,252 <italic>BRCA1</italic> and 8,211 <italic>BRCA2</italic> mutation carriers, for known variants (n=3,248) located within or around 445 candidate genes, were available through the iCOGS custom-designed array. Breast and ovarian cancer association analysis was performed within a retrospective cohort approach.</p></sec><sec id="S3"><title>Results</title><p id="P3">The observed p-values of association ranged between 0.005-1.000. None of the variants was significantly associated with breast or ovarian cancer risk in either <italic>BRCA1</italic> or <italic>BRCA2</italic> mutation carriers, after multiple testing adjustments.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">There is little evidence that any of the evaluated candidate variants act as modifiers of breast and/or ovarian cancer risk in <italic>BRCA1</italic> or <italic>BRCA2</italic> mutation carriers.</p></sec><sec id="S5"><title>Impact</title><p id="P5">Genome-wide association studies have been more successful at identifying genetic modifiers of <italic>BRCA1/2</italic> penetrance than candidate gene studies.</p></sec></abstract><kwd-group><kwd><italic>BRCA1 BRCA2</italic> mutations</kwd><kwd><italic>BRCA</italic>-mutation carriers, Breast cancer risk</kwd><kwd>Ovarian cancer risk</kwd><kwd>Candidate genetic risk modifiers</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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