Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Association of Genetic Susceptibility Variants for Type 2 Diabetes with Breast Cancer Risk in Women of European Ancestry</title><author><name sortKey="Zhao, Zhiguo" sort="Zhao, Zhiguo" uniqKey="Zhao Z" first="Zhiguo" last="Zhao">Zhiguo Zhao</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Division of Cancer Biostatistics, Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Wen, Wanqing" sort="Wen, Wanqing" uniqKey="Wen W" first="Wanqing" last="Wen">Wanqing Wen</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Zhang, Ben" sort="Zhang, Ben" uniqKey="Zhang B" first="Ben" last="Zhang">Ben Zhang</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Long, Jirong" sort="Long, Jirong" uniqKey="Long J" first="Jirong" last="Long">Jirong Long</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name><affiliation><nlm:aff id="A4">Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation><nlm:aff id="A5">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Centre for Epidemiology and Biostatistics, School of Population and Global health, The University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name><affiliation><nlm:aff id="A7">Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="A9">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindstrom">Sara Lindstrom</name><affiliation><nlm:aff id="A11">Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="A13">Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A15">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Ahsan, Habibul" sort="Ahsan, Habibul" uniqKey="Ahsan H" first="Habibul" last="Ahsan">Habibul Ahsan</name><affiliation><nlm:aff id="A16">Department of Health Studies, The University of Chicago, Chicago, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff id="A17">Department of Clinical Genetics, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="A18">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A19">Department of Molecular Genetics, University of Toronto, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation><nlm:aff id="A20">Department of Epidemiology, University of California Irvine, Irvine, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="A21">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="A22">Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Beeghly Fadiel, Alicia" sort="Beeghly Fadiel, Alicia" uniqKey="Beeghly Fadiel A" first="Alicia" last="Beeghly-Fadiel">Alicia Beeghly-Fadiel</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation><nlm:aff id="A23">Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Centro de Investigación en Red de Enfermedades Raras, Valencia, Spain</nlm:aff></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation><nlm:aff id="A25">Department of Oncology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V." last="Bogdanova">Natalia V. Bogdanova</name><affiliation><nlm:aff id="A26">Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="B Rresen Dale, Anne Lise" sort="B Rresen Dale, Anne Lise" uniqKey="B Rresen Dale A" first="Anne-Lise" last="B Rresen-Dale">Anne-Lise B Rresen-Dale</name><affiliation><nlm:aff id="A27">Department of Genetics, Institute for Cancer Research, Radium hospitalet, Oslo University Hospital, Oslo University Hospital, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A28">K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Brand, Judith" sort="Brand, Judith" uniqKey="Brand J" first="Judith" last="Brand">Judith Brand</name><affiliation><nlm:aff id="A29">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation><nlm:aff id="A30">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A31">University of Tübingen, Tübingen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A32">German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="A21">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A32">German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Division of Preventive Oncology, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation><nlm:aff id="A34">Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A35">Molecular Epidemiology Group, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Cai, Qiuyin" sort="Cai, Qiuyin" uniqKey="Cai Q" first="Qiuyin" last="Cai">Qiuyin Cai</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name><affiliation><nlm:aff id="A36">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="A37">Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="A38">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="A39">Sheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name><affiliation><nlm:aff id="A40">Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="A29">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation><nlm:aff id="A41">Gynaecology Research Unit, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name><affiliation><nlm:aff id="A42">Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Canada</nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="A22">Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A43">David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name><affiliation><nlm:aff id="A44">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff id="A45">Institute for Medical Biometrics and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A46">Department of Cancer Epidemiology, Clinical Cancer Registry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:aff id="A8">Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation><nlm:aff id="A47">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Fostira, Florentia" sort="Fostira, Florentia" uniqKey="Fostira F" first="Florentia" last="Fostira">Florentia Fostira</name><affiliation><nlm:aff id="A48">Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research "Demokritos", Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Gammon, Marilie" sort="Gammon, Marilie" uniqKey="Gammon M" first="Marilie" last="Gammon">Marilie Gammon</name><affiliation><nlm:aff id="A49">Departments of Epidemiology, University of North Carolina Chapel-Hill, Chapel Hill, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="A5">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Centre for Epidemiology and Biostatistics, School of Population and Global health, The University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation><nlm:aff id="A50">Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 94807, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A51">University Paris-Sud, UMRS 1018, 94807, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff id="A52">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="A53">Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Harrington, Patricia" sort="Harrington, Patricia" uniqKey="Harrington P" first="Patricia" last="Harrington">Patricia Harrington</name><affiliation><nlm:aff id="A54">Department of Oncology, University of Cambridge, Strange ways Research Laboratory, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Hartman, Mikael" sort="Hartman, Mikael" uniqKey="Hartman M" first="Mikael" last="Hartman">Mikael Hartman</name><affiliation><nlm:aff id="A55">Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name><affiliation><nlm:aff id="A56">Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="A6">Centre for Epidemiology and Biostatistics, School of Population and Global health, The University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="A57">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Jasmine, Farzana" sort="Jasmine, Farzana" uniqKey="Jasmine F" first="Farzana" last="Jasmine">Farzana Jasmine</name><affiliation><nlm:aff id="A16">Department of Health Studies, The University of Chicago, Chicago, IL, USA</nlm:aff></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name><affiliation><nlm:aff id="A58">Cancer Prevention Institute of California, Fremont, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A59">Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation><nlm:aff id="A8">Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kabisch, Maria" sort="Kabisch, Maria" uniqKey="Kabisch M" first="Maria" last="Kabisch">Maria Kabisch</name><affiliation><nlm:aff id="A53">Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Khan, Sofia" sort="Khan, Sofia" uniqKey="Khan S" first="Sofia" last="Khan">Sofia Khan</name><affiliation><nlm:aff id="A60">Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Kibriya, Muhammad" sort="Kibriya, Muhammad" uniqKey="Kibriya M" first="Muhammad" last="Kibriya">Muhammad Kibriya</name><affiliation><nlm:aff id="A16">Department of Health Studies, The University of Chicago, Chicago, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name><affiliation><nlm:aff id="A61">Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A62">Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation><nlm:aff id="A63">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A64">Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A65">Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kriege, Mieke" sort="Kriege, Mieke" uniqKey="Kriege M" first="Mieke" last="Kriege">Mieke Kriege</name><affiliation><nlm:aff id="A56">Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name><affiliation><nlm:aff id="A27">Department of Genetics, Institute for Cancer Research, Radium hospitalet, Oslo University Hospital, Oslo University Hospital, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A28">K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A66">Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="A67">University of Hawaii Cancer Center, Honolulu, HI, USA</nlm:aff></affiliation></author><author><name sortKey="Lee, Eunjung" sort="Lee, Eunjung" uniqKey="Lee E" first="Eunjung" last="Lee">Eunjung Lee</name><affiliation><nlm:aff id="A36">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name><affiliation><nlm:aff id="A29">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation><nlm:aff id="A68">Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lophatananon, Artitaya" sort="Lophatananon, Artitaya" uniqKey="Lophatananon A" first="Artitaya" last="Lophatananon">Artitaya Lophatananon</name><affiliation><nlm:aff id="A69">Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK</nlm:aff></affiliation></author><author><name sortKey="Luben, Robert" sort="Luben, Robert" uniqKey="Luben R" first="Robert" last="Luben">Robert Luben</name><affiliation><nlm:aff id="A70">Clinical Gerontology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="A57">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Malone, Kathleen E" sort="Malone, Kathleen E" uniqKey="Malone K" first="Kathleen E." last="Malone">Kathleen E. Malone</name><affiliation><nlm:aff id="A71">Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation><nlm:aff id="A63">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A64">Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A65">Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation><nlm:aff id="A72">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation><nlm:aff id="A73">Department of Oncology - Pathology, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name><affiliation><nlm:aff id="A74">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A75">National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Mclean, Catriona" sort="Mclean, Catriona" uniqKey="Mclean C" first="Catriona" last="Mclean">Catriona Mclean</name><affiliation><nlm:aff id="A76">Anatomical Pathology, The Alfred Hospital, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Meijers Heijboer, Hanne" sort="Meijers Heijboer, Hanne" uniqKey="Meijers Heijboer H" first="Hanne" last="Meijers-Heijboer">Hanne Meijers-Heijboer</name><affiliation><nlm:aff id="A77">Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="A78">Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Miao, Hui" sort="Miao, Hui" uniqKey="Miao H" first="Hui" last="Miao">Hui Miao</name><affiliation><nlm:aff id="A55">Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><affiliation><nlm:aff id="A69">Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A79">Institute of Population Health, University of Manchester, Manchester, UK</nlm:aff></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name><affiliation><nlm:aff id="A80">Beckman Research Institute of City of Hope, Duarte, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="A60">Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Neven, Patrick" sort="Neven, Patrick" uniqKey="Neven P" first="Patrick" last="Neven">Patrick Neven</name><affiliation><nlm:aff id="A81">Multidisciplinary Breast Centre and Gynaecological Oncology, KU Leuven - University of Leuven, University Hospitals Leuven, Department of Oncology, B-3000 Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name><affiliation><nlm:aff id="A82">Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Perkins, Barbara" sort="Perkins, Barbara" uniqKey="Perkins B" first="Barbara" last="Perkins">Barbara Perkins</name><affiliation><nlm:aff id="A83">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="A84">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Phillips, Kelly Anne" sort="Phillips, Kelly Anne" uniqKey="Phillips K" first="Kelly-Anne" last="Phillips">Kelly-Anne Phillips</name><affiliation><nlm:aff id="A85">Peter MacCallum Cancer Center, The University of Melbourne, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A86">Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A87">Department of Medicine, St Vincent’s Hospital, The University of Melbourne, Fitzroy, Australia</nlm:aff></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation><nlm:aff id="A88">Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="A9">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Santella, Regina" sort="Santella, Regina" uniqKey="Santella R" first="Regina" last="Santella">Regina Santella</name><affiliation><nlm:aff id="A89">Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A90">Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J." last="Sawyer">Elinor J. Sawyer</name><affiliation><nlm:aff id="A91">Research Oncology, Guy’s Hospital, King's College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="A92">Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A93">Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A94">Center for Molecular Medicine, University Hospital of Cologne, Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A95">Center of Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Schoemaker, Minouk" sort="Schoemaker, Minouk" uniqKey="Schoemaker M" first="Minouk" last="Schoemaker">Minouk Schoemaker</name><affiliation><nlm:aff id="A7">Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Shah, Mitul" sort="Shah, Mitul" uniqKey="Shah M" first="Mitul" last="Shah">Mitul Shah</name><affiliation><nlm:aff id="A83">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Shrubsole, Martha" sort="Shrubsole, Martha" uniqKey="Shrubsole M" first="Martha" last="Shrubsole">Martha Shrubsole</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="A96">Department of Pathology, The University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Swerdlow, Anthony J" sort="Swerdlow, Anthony J" uniqKey="Swerdlow A" first="Anthony J" last="Swerdlow">Anthony J. Swerdlow</name><affiliation><nlm:aff id="A7">Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A97">Division of Breast Cancer Research, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E." last="Toland">Amanda E. Toland</name><affiliation><nlm:aff id="A98">Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA</nlm:aff></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation><nlm:aff id="A99">Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name><affiliation><nlm:aff id="A53">Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation><nlm:aff id="A50">Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 94807, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A51">University Paris-Sud, UMRS 1018, 94807, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Ursin, Giske" sort="Ursin, Giske" uniqKey="Ursin G" first="Giske" last="Ursin">Giske Ursin</name><affiliation><nlm:aff id="A100">Cancer Registry of Norway, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A106">Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Van Der Luijt, Rob B" sort="Van Der Luijt, Rob B" uniqKey="Van Der Luijt R" first="Rob B." last="Van Der Luijt">Rob B. Van Der Luijt</name><affiliation><nlm:aff id="A101">Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Verhoef, Senno" sort="Verhoef, Senno" uniqKey="Verhoef S" first="Senno" last="Verhoef">Senno Verhoef</name><affiliation><nlm:aff id="A4">Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wang Gohrke, Shan" sort="Wang Gohrke, Shan" uniqKey="Wang Gohrke S" first="Shan" last="Wang-Gohrke">Shan Wang-Gohrke</name><affiliation><nlm:aff id="A10">Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S." last="Whittemore">Alice S. Whittemore</name><affiliation><nlm:aff id="A59">Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation><nlm:aff id="A88">Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A102">Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Zamora, M Pilar" sort="Zamora, M Pilar" uniqKey="Zamora M" first="M. Pilar" last="Zamora">M. Pilar Zamora</name><affiliation><nlm:aff id="A103">Servicio de Oncología Médica, Hospital Universitario La Paz, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Zhao, Hui" sort="Zhao, Hui" uniqKey="Zhao H" first="Hui" last="Zhao">Hui Zhao</name><affiliation><nlm:aff id="A104">Vesalius Research Center, Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A105">Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="A83">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="A42">Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Canada</nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="A29">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:aff id="A11">Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul" sort="Pharoah, Paul" uniqKey="Pharoah P" first="Paul" last="Pharoah">Paul Pharoah</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A83">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Hunter, David" sort="Hunter, David" uniqKey="Hunter D" first="David" last="Hunter">David Hunter</name><affiliation><nlm:aff id="A11">Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A83">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27053251</idno><idno type="pmc">5029371</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029371</idno><idno type="RBID">PMC:5029371</idno><idno type="doi">10.1007/s10552-016-0741-6</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">002073</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002073</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Association of Genetic Susceptibility Variants for Type 2 Diabetes with Breast Cancer Risk in Women of European Ancestry</title><author><name sortKey="Zhao, Zhiguo" sort="Zhao, Zhiguo" uniqKey="Zhao Z" first="Zhiguo" last="Zhao">Zhiguo Zhao</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Division of Cancer Biostatistics, Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Wen, Wanqing" sort="Wen, Wanqing" uniqKey="Wen W" first="Wanqing" last="Wen">Wanqing Wen</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Zhang, Ben" sort="Zhang, Ben" uniqKey="Zhang B" first="Ben" last="Zhang">Ben Zhang</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Long, Jirong" sort="Long, Jirong" uniqKey="Long J" first="Jirong" last="Long">Jirong Long</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name><affiliation><nlm:aff id="A4">Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><affiliation><nlm:aff id="A5">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Centre for Epidemiology and Biostatistics, School of Population and Global health, The University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name><affiliation><nlm:aff id="A7">Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="A9">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindstrom">Sara Lindstrom</name><affiliation><nlm:aff id="A11">Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><affiliation><nlm:aff id="A13">Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation><affiliation><nlm:aff id="A15">Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Ahsan, Habibul" sort="Ahsan, Habibul" uniqKey="Ahsan H" first="Habibul" last="Ahsan">Habibul Ahsan</name><affiliation><nlm:aff id="A16">Department of Health Studies, The University of Chicago, Chicago, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff id="A17">Department of Clinical Genetics, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:aff id="A18">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A19">Department of Molecular Genetics, University of Toronto, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation><nlm:aff id="A20">Department of Epidemiology, University of California Irvine, Irvine, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><affiliation><nlm:aff id="A21">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><affiliation><nlm:aff id="A22">Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany</nlm:aff></affiliation></author><author><name sortKey="Beeghly Fadiel, Alicia" sort="Beeghly Fadiel, Alicia" uniqKey="Beeghly Fadiel A" first="Alicia" last="Beeghly-Fadiel">Alicia Beeghly-Fadiel</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><affiliation><nlm:aff id="A23">Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Centro de Investigación en Red de Enfermedades Raras, Valencia, Spain</nlm:aff></affiliation></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><affiliation><nlm:aff id="A25">Department of Oncology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V." last="Bogdanova">Natalia V. Bogdanova</name><affiliation><nlm:aff id="A26">Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="B Rresen Dale, Anne Lise" sort="B Rresen Dale, Anne Lise" uniqKey="B Rresen Dale A" first="Anne-Lise" last="B Rresen-Dale">Anne-Lise B Rresen-Dale</name><affiliation><nlm:aff id="A27">Department of Genetics, Institute for Cancer Research, Radium hospitalet, Oslo University Hospital, Oslo University Hospital, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A28">K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Brand, Judith" sort="Brand, Judith" uniqKey="Brand J" first="Judith" last="Brand">Judith Brand</name><affiliation><nlm:aff id="A29">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><affiliation><nlm:aff id="A30">Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A31">University of Tübingen, Tübingen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A32">German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="A21">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A32">German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Division of Preventive Oncology, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><affiliation><nlm:aff id="A34">Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A35">Molecular Epidemiology Group, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Cai, Qiuyin" sort="Cai, Qiuyin" uniqKey="Cai Q" first="Qiuyin" last="Cai">Qiuyin Cai</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name><affiliation><nlm:aff id="A36">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><nlm:aff id="A37">Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia</nlm:aff></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><nlm:aff id="A38">Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:aff id="A39">Sheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name><affiliation><nlm:aff id="A40">Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK</nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="A29">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><affiliation><nlm:aff id="A41">Gynaecology Research Unit, Hannover Medical School, Hannover, Germany</nlm:aff></affiliation></author><author><name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name><affiliation><nlm:aff id="A42">Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Canada</nlm:aff></affiliation></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><affiliation><nlm:aff id="A22">Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A43">David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name><affiliation><nlm:aff id="A44">Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff id="A45">Institute for Medical Biometrics and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A46">Department of Cancer Epidemiology, Clinical Cancer Registry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:aff id="A8">Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><affiliation><nlm:aff id="A47">Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</nlm:aff></affiliation></author><author><name sortKey="Fostira, Florentia" sort="Fostira, Florentia" uniqKey="Fostira F" first="Florentia" last="Fostira">Florentia Fostira</name><affiliation><nlm:aff id="A48">Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research "Demokritos", Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Gammon, Marilie" sort="Gammon, Marilie" uniqKey="Gammon M" first="Marilie" last="Gammon">Marilie Gammon</name><affiliation><nlm:aff id="A49">Departments of Epidemiology, University of North Carolina Chapel-Hill, Chapel Hill, NC, USA</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="A5">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Centre for Epidemiology and Biostatistics, School of Population and Global health, The University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><affiliation><nlm:aff id="A50">Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 94807, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A51">University Paris-Sud, UMRS 1018, 94807, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff id="A52">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><nlm:aff id="A53">Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Harrington, Patricia" sort="Harrington, Patricia" uniqKey="Harrington P" first="Patricia" last="Harrington">Patricia Harrington</name><affiliation><nlm:aff id="A54">Department of Oncology, University of Cambridge, Strange ways Research Laboratory, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Hartman, Mikael" sort="Hartman, Mikael" uniqKey="Hartman M" first="Mikael" last="Hartman">Mikael Hartman</name><affiliation><nlm:aff id="A55">Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name><affiliation><nlm:aff id="A56">Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="A6">Centre for Epidemiology and Biostatistics, School of Population and Global health, The University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><affiliation><nlm:aff id="A57">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Jasmine, Farzana" sort="Jasmine, Farzana" uniqKey="Jasmine F" first="Farzana" last="Jasmine">Farzana Jasmine</name><affiliation><nlm:aff id="A16">Department of Health Studies, The University of Chicago, Chicago, IL, USA</nlm:aff></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name><affiliation><nlm:aff id="A58">Cancer Prevention Institute of California, Fremont, CA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A59">Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation><nlm:aff id="A8">Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Kabisch, Maria" sort="Kabisch, Maria" uniqKey="Kabisch M" first="Maria" last="Kabisch">Maria Kabisch</name><affiliation><nlm:aff id="A53">Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Khan, Sofia" sort="Khan, Sofia" uniqKey="Khan S" first="Sofia" last="Khan">Sofia Khan</name><affiliation><nlm:aff id="A60">Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Kibriya, Muhammad" sort="Kibriya, Muhammad" uniqKey="Kibriya M" first="Muhammad" last="Kibriya">Muhammad Kibriya</name><affiliation><nlm:aff id="A16">Department of Health Studies, The University of Chicago, Chicago, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name><affiliation><nlm:aff id="A61">Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A62">Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><affiliation><nlm:aff id="A63">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A64">Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A65">Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Kriege, Mieke" sort="Kriege, Mieke" uniqKey="Kriege M" first="Mieke" last="Kriege">Mieke Kriege</name><affiliation><nlm:aff id="A56">Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name><affiliation><nlm:aff id="A27">Department of Genetics, Institute for Cancer Research, Radium hospitalet, Oslo University Hospital, Oslo University Hospital, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A28">K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A66">Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="A67">University of Hawaii Cancer Center, Honolulu, HI, USA</nlm:aff></affiliation></author><author><name sortKey="Lee, Eunjung" sort="Lee, Eunjung" uniqKey="Lee E" first="Eunjung" last="Lee">Eunjung Lee</name><affiliation><nlm:aff id="A36">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name><affiliation><nlm:aff id="A29">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><affiliation><nlm:aff id="A68">Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lophatananon, Artitaya" sort="Lophatananon, Artitaya" uniqKey="Lophatananon A" first="Artitaya" last="Lophatananon">Artitaya Lophatananon</name><affiliation><nlm:aff id="A69">Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK</nlm:aff></affiliation></author><author><name sortKey="Luben, Robert" sort="Luben, Robert" uniqKey="Luben R" first="Robert" last="Luben">Robert Luben</name><affiliation><nlm:aff id="A70">Clinical Gerontology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><affiliation><nlm:aff id="A57">Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</nlm:aff></affiliation></author><author><name sortKey="Malone, Kathleen E" sort="Malone, Kathleen E" uniqKey="Malone K" first="Kathleen E." last="Malone">Kathleen E. Malone</name><affiliation><nlm:aff id="A71">Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><affiliation><nlm:aff id="A63">Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A64">Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A65">Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland</nlm:aff></affiliation></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><affiliation><nlm:aff id="A72">Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><affiliation><nlm:aff id="A73">Department of Oncology - Pathology, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name><affiliation><nlm:aff id="A74">Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A75">National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Mclean, Catriona" sort="Mclean, Catriona" uniqKey="Mclean C" first="Catriona" last="Mclean">Catriona Mclean</name><affiliation><nlm:aff id="A76">Anatomical Pathology, The Alfred Hospital, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Meijers Heijboer, Hanne" sort="Meijers Heijboer, Hanne" uniqKey="Meijers Heijboer H" first="Hanne" last="Meijers-Heijboer">Hanne Meijers-Heijboer</name><affiliation><nlm:aff id="A77">Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="A78">Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Miao, Hui" sort="Miao, Hui" uniqKey="Miao H" first="Hui" last="Miao">Hui Miao</name><affiliation><nlm:aff id="A55">Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><affiliation><nlm:aff id="A69">Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A79">Institute of Population Health, University of Manchester, Manchester, UK</nlm:aff></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name><affiliation><nlm:aff id="A80">Beckman Research Institute of City of Hope, Duarte, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="A60">Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Neven, Patrick" sort="Neven, Patrick" uniqKey="Neven P" first="Patrick" last="Neven">Patrick Neven</name><affiliation><nlm:aff id="A81">Multidisciplinary Breast Centre and Gynaecological Oncology, KU Leuven - University of Leuven, University Hospitals Leuven, Department of Oncology, B-3000 Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name><affiliation><nlm:aff id="A82">Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</nlm:aff></affiliation></author><author><name sortKey="Perkins, Barbara" sort="Perkins, Barbara" uniqKey="Perkins B" first="Barbara" last="Perkins">Barbara Perkins</name><affiliation><nlm:aff id="A83">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><nlm:aff id="A84">IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Phillips, Kelly Anne" sort="Phillips, Kelly Anne" uniqKey="Phillips K" first="Kelly-Anne" last="Phillips">Kelly-Anne Phillips</name><affiliation><nlm:aff id="A85">Peter MacCallum Cancer Center, The University of Melbourne, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A86">Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A87">Department of Medicine, St Vincent’s Hospital, The University of Melbourne, Fitzroy, Australia</nlm:aff></affiliation></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><affiliation><nlm:aff id="A88">Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="A9">Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Santella, Regina" sort="Santella, Regina" uniqKey="Santella R" first="Regina" last="Santella">Regina Santella</name><affiliation><nlm:aff id="A89">Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A90">Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J." last="Sawyer">Elinor J. Sawyer</name><affiliation><nlm:aff id="A91">Research Oncology, Guy’s Hospital, King's College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="A92">Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A93">Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A94">Center for Molecular Medicine, University Hospital of Cologne, Cologne, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A95">Center of Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Schoemaker, Minouk" sort="Schoemaker, Minouk" uniqKey="Schoemaker M" first="Minouk" last="Schoemaker">Minouk Schoemaker</name><affiliation><nlm:aff id="A7">Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Shah, Mitul" sort="Shah, Mitul" uniqKey="Shah M" first="Mitul" last="Shah">Mitul Shah</name><affiliation><nlm:aff id="A83">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Shrubsole, Martha" sort="Shrubsole, Martha" uniqKey="Shrubsole M" first="Martha" last="Shrubsole">Martha Shrubsole</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="A96">Department of Pathology, The University of Melbourne, Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Swerdlow, Anthony J" sort="Swerdlow, Anthony J" uniqKey="Swerdlow A" first="Anthony J" last="Swerdlow">Anthony J. Swerdlow</name><affiliation><nlm:aff id="A7">Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A97">Division of Breast Cancer Research, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E." last="Toland">Amanda E. Toland</name><affiliation><nlm:aff id="A98">Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA</nlm:aff></affiliation></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><affiliation><nlm:aff id="A99">Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name><affiliation><nlm:aff id="A53">Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><affiliation><nlm:aff id="A50">Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 94807, Villejuif, France</nlm:aff></affiliation><affiliation><nlm:aff id="A51">University Paris-Sud, UMRS 1018, 94807, Villejuif, France</nlm:aff></affiliation></author><author><name sortKey="Ursin, Giske" sort="Ursin, Giske" uniqKey="Ursin G" first="Giske" last="Ursin">Giske Ursin</name><affiliation><nlm:aff id="A100">Cancer Registry of Norway, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A106">Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway</nlm:aff></affiliation></author><author><name sortKey="Van Der Luijt, Rob B" sort="Van Der Luijt, Rob B" uniqKey="Van Der Luijt R" first="Rob B." last="Van Der Luijt">Rob B. Van Der Luijt</name><affiliation><nlm:aff id="A101">Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Verhoef, Senno" sort="Verhoef, Senno" uniqKey="Verhoef S" first="Senno" last="Verhoef">Senno Verhoef</name><affiliation><nlm:aff id="A4">Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wang Gohrke, Shan" sort="Wang Gohrke, Shan" uniqKey="Wang Gohrke S" first="Shan" last="Wang-Gohrke">Shan Wang-Gohrke</name><affiliation><nlm:aff id="A10">Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany</nlm:aff></affiliation></author><author><name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S." last="Whittemore">Alice S. Whittemore</name><affiliation><nlm:aff id="A59">Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><affiliation><nlm:aff id="A88">Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu, Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A102">Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland</nlm:aff></affiliation></author><author><name sortKey="Zamora, M Pilar" sort="Zamora, M Pilar" uniqKey="Zamora M" first="M. Pilar" last="Zamora">M. Pilar Zamora</name><affiliation><nlm:aff id="A103">Servicio de Oncología Médica, Hospital Universitario La Paz, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Zhao, Hui" sort="Zhao, Hui" uniqKey="Zhao H" first="Hui" last="Zhao">Hui Zhao</name><affiliation><nlm:aff id="A104">Vesalius Research Center, Leuven, Belgium</nlm:aff></affiliation><affiliation><nlm:aff id="A105">Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation><nlm:aff id="A83">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:aff id="A42">Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Canada</nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="A29">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:aff id="A11">Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul" sort="Pharoah, Paul" uniqKey="Pharoah P" first="Paul" last="Pharoah">Paul Pharoah</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A83">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Hunter, David" sort="Hunter, David" uniqKey="Hunter D" first="David" last="Hunter">David Hunter</name><affiliation><nlm:aff id="A11">Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="A3">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A83">Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation><nlm:aff id="A1">Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Cancer causes & control : CCC</title><idno type="ISSN">0957-5243</idno><idno type="eISSN">1573-7225</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title><p id="P1">Type 2 diabetes (T2D) has been reported to be associated with an elevated risk of breast cancer. It is unclear, however, whether this association is due to shared genetic factors.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We constructed a genetic risk score (GRS) using risk variants from 33 known independent T2D susceptibility loci and evaluated its relation to breast cancer risk using the data from two consortia, including 62,328 breast cancer patients and 83,817 controls of European ancestry. Unconditional logistic regression models were used to derive adjusted odds ratios (OR) and 95% confidence intervals (CI) to measure the association of breast cancer risk with T2D GRS or T2D-associated genetic risk variants. Meta-analyses were conducted to obtain summary ORs across all studies.</p></sec><sec id="S3"><title>Results</title><p id="P3">The T2D GRS was not found to be associated with breast cancer risk, overall, by menopausal status, or for estrogen receptor positive or negative breast cancer. Three T2D associated risk variants were individually associated with breast cancer risk after adjustment for multiple comparisons using the Bonferroni method (at <italic>P</italic> < 0.001), rs9939609 (<italic>FTO</italic>) (OR = 0.94, 95% CI = 0.92 – 0.95, <italic>P</italic> = 4.13E-13), rs7903146 (<italic>TCF7L2</italic>) (OR = 1.04, 95% CI = 1.02 – 1.06, <italic>P</italic> = 1.26E-05), and rs8042680 (<italic>PRC1</italic>) (OR = 0.97, 95% CI = 0.95 – 0.99, <italic>P</italic> = 8.05E-04).</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">We have shown that several genetic risk variants were associated with the risk of both T2D and breast cancer. However, overall genetic susceptibility to T2D may not be related to breast cancer risk.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9100846</journal-id><journal-id journal-id-type="pubmed-jr-id">1173</journal-id><journal-id journal-id-type="nlm-ta">Cancer Causes Control</journal-id><journal-id journal-id-type="iso-abbrev">Cancer Causes Control</journal-id><journal-title-group><journal-title>Cancer causes & control : CCC</journal-title></journal-title-group><issn pub-type="ppub">0957-5243</issn><issn pub-type="epub">1573-7225</issn></journal-meta><article-meta><article-id pub-id-type="pmid">27053251</article-id><article-id pub-id-type="pmc">5029371</article-id><article-id pub-id-type="doi">10.1007/s10552-016-0741-6</article-id><article-id pub-id-type="manuscript">NIHMS816843</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Association of Genetic Susceptibility Variants for Type 2 Diabetes with Breast Cancer Risk in Women of European Ancestry</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>Zhiguo</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Wen</surname><given-names>Wanqing</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Michailidou</surname><given-names>Kyriaki</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Bolla</surname><given-names>Manjeet K.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Qin</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Ben</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Long</surname><given-names>Jirong</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Shu</surname><given-names>Xiao-Ou</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Schmidt</surname><given-names>Marjanka K.</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Milne</surname><given-names>Roger L.</given-names></name><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>García-Closas</surname><given-names>Montserrat</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Chang-Claude</surname><given-names>Jenny</given-names></name><xref ref-type="aff" rid="A9">9</xref><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Lindstrom</surname><given-names>Sara</given-names></name><xref ref-type="aff" rid="A11">11</xref><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Bojesen</surname><given-names>Stig E.</given-names></name><xref ref-type="aff" rid="A13">13</xref><xref ref-type="aff" rid="A14">14</xref><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Ahsan</surname><given-names>Habibul</given-names></name><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Aittomäki</surname><given-names>Kristiina</given-names></name><xref ref-type="aff" rid="A17">17</xref></contrib><contrib contrib-type="author"><name><surname>Andrulis</surname><given-names>Irene L.</given-names></name><xref ref-type="aff" rid="A18">18</xref><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Anton-Culver</surname><given-names>Hoda</given-names></name><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Arndt</surname><given-names>Volker</given-names></name><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Beckmann</surname><given-names>Matthias W.</given-names></name><xref ref-type="aff" rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>Beeghly-Fadiel</surname><given-names>Alicia</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Benitez</surname><given-names>Javier</given-names></name><xref ref-type="aff" rid="A23">23</xref><xref ref-type="aff" rid="A24">24</xref></contrib><contrib contrib-type="author"><name><surname>Blomqvist</surname><given-names>Carl</given-names></name><xref ref-type="aff" rid="A25">25</xref></contrib><contrib contrib-type="author"><name><surname>Bogdanova</surname><given-names>Natalia V.</given-names></name><xref ref-type="aff" rid="A26">26</xref></contrib><contrib contrib-type="author"><name><surname>Børresen-Dale</surname><given-names>Anne-Lise</given-names></name><xref ref-type="aff" rid="A27">27</xref><xref ref-type="aff" rid="A28">28</xref></contrib><contrib contrib-type="author"><name><surname>Brand</surname><given-names>Judith</given-names></name><xref ref-type="aff" rid="A29">29</xref></contrib><contrib contrib-type="author"><name><surname>Brauch</surname><given-names>Hiltrud</given-names></name><xref ref-type="aff" rid="A30">30</xref><xref ref-type="aff" rid="A31">31</xref><xref ref-type="aff" rid="A32">32</xref></contrib><contrib contrib-type="author"><name><surname>Brenner</surname><given-names>Hermann</given-names></name><xref ref-type="aff" rid="A21">21</xref><xref ref-type="aff" rid="A32">32</xref><xref ref-type="aff" rid="A33">33</xref></contrib><contrib contrib-type="author"><name><surname>Burwinkel</surname><given-names>Barbara</given-names></name><xref ref-type="aff" rid="A34">34</xref><xref ref-type="aff" rid="A35">35</xref></contrib><contrib contrib-type="author"><name><surname>Cai</surname><given-names>Qiuyin</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Casey</surname><given-names>Graham</given-names></name><xref ref-type="aff" rid="A36">36</xref></contrib><contrib contrib-type="author"><name><surname>Chenevix-Trench</surname><given-names>Georgia</given-names></name><xref ref-type="aff" rid="A37">37</xref></contrib><contrib contrib-type="author"><name><surname>Couch</surname><given-names>Fergus J.</given-names></name><xref ref-type="aff" rid="A38">38</xref></contrib><contrib contrib-type="author"><name><surname>Cox</surname><given-names>Angela</given-names></name><xref ref-type="aff" rid="A39">39</xref></contrib><contrib contrib-type="author"><name><surname>Cross</surname><given-names>Simon S.</given-names></name><xref ref-type="aff" rid="A40">40</xref></contrib><contrib contrib-type="author"><name><surname>Czene</surname><given-names>Kamila</given-names></name><xref ref-type="aff" rid="A29">29</xref></contrib><contrib contrib-type="author"><name><surname>Dörk</surname><given-names>Thilo</given-names></name><xref ref-type="aff" rid="A41">41</xref></contrib><contrib contrib-type="author"><name><surname>Dumont</surname><given-names>Martine</given-names></name><xref ref-type="aff" rid="A42">42</xref></contrib><contrib contrib-type="author"><name><surname>Fasching</surname><given-names>Peter A.</given-names></name><xref ref-type="aff" rid="A22">22</xref><xref ref-type="aff" rid="A43">43</xref></contrib><contrib contrib-type="author"><name><surname>Figueroa</surname><given-names>Jonine</given-names></name><xref ref-type="aff" rid="A44">44</xref></contrib><contrib contrib-type="author"><name><surname>Flesch-Janys</surname><given-names>Dieter</given-names></name><xref ref-type="aff" rid="A45">45</xref><xref ref-type="aff" rid="A46">46</xref></contrib><contrib contrib-type="author"><name><surname>Fletcher</surname><given-names>Olivia</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Flyger</surname><given-names>Henrik</given-names></name><xref ref-type="aff" rid="A47">47</xref></contrib><contrib contrib-type="author"><name><surname>Fostira</surname><given-names>Florentia</given-names></name><xref ref-type="aff" rid="A48">48</xref></contrib><contrib contrib-type="author"><name><surname>Gammon</surname><given-names>Marilie</given-names></name><xref ref-type="aff" rid="A49">49</xref></contrib><contrib contrib-type="author"><name><surname>Giles</surname><given-names>Graham G.</given-names></name><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Guénel</surname><given-names>Pascal</given-names></name><xref ref-type="aff" rid="A50">50</xref><xref ref-type="aff" rid="A51">51</xref></contrib><contrib contrib-type="author"><name><surname>Haiman</surname><given-names>Christopher A.</given-names></name><xref ref-type="aff" rid="A52">52</xref></contrib><contrib contrib-type="author"><name><surname>Hamann</surname><given-names>Ute</given-names></name><xref ref-type="aff" rid="A53">53</xref></contrib><contrib contrib-type="author"><name><surname>Harrington</surname><given-names>Patricia</given-names></name><xref ref-type="aff" rid="A54">54</xref></contrib><contrib contrib-type="author"><name><surname>Hartman</surname><given-names>Mikael</given-names></name><xref ref-type="aff" rid="A55">55</xref></contrib><contrib contrib-type="author"><name><surname>Hooning</surname><given-names>Maartje J.</given-names></name><xref ref-type="aff" rid="A56">56</xref></contrib><contrib contrib-type="author"><name><surname>Hopper</surname><given-names>John L.</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Jakubowska</surname><given-names>Anna</given-names></name><xref ref-type="aff" rid="A57">57</xref></contrib><contrib contrib-type="author"><name><surname>Jasmine</surname><given-names>Farzana</given-names></name><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>John</surname><given-names>Esther M.</given-names></name><xref ref-type="aff" rid="A58">58</xref><xref ref-type="aff" rid="A59">59</xref></contrib><contrib contrib-type="author"><name><surname>Johnson</surname><given-names>Nichola</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Kabisch</surname><given-names>Maria</given-names></name><xref ref-type="aff" rid="A53">53</xref></contrib><contrib contrib-type="author"><name><surname>Khan</surname><given-names>Sofia</given-names></name><xref ref-type="aff" rid="A60">60</xref></contrib><contrib contrib-type="author"><name><surname>Kibriya</surname><given-names>Muhammad</given-names></name><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Knight</surname><given-names>Julia A.</given-names></name><xref ref-type="aff" rid="A61">61</xref><xref ref-type="aff" rid="A62">62</xref></contrib><contrib contrib-type="author"><name><surname>Kosma</surname><given-names>Veli-Matti</given-names></name><xref ref-type="aff" rid="A63">63</xref><xref ref-type="aff" rid="A64">64</xref><xref ref-type="aff" rid="A65">65</xref></contrib><contrib contrib-type="author"><name><surname>Kriege</surname><given-names>Mieke</given-names></name><xref ref-type="aff" rid="A56">56</xref></contrib><contrib contrib-type="author"><name><surname>Kristensen</surname><given-names>Vessela</given-names></name><xref ref-type="aff" rid="A27">27</xref><xref ref-type="aff" rid="A28">28</xref><xref ref-type="aff" rid="A66">66</xref></contrib><contrib contrib-type="author"><name><surname>Le Marchand</surname><given-names>Loic</given-names></name><xref ref-type="aff" rid="A67">67</xref></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Eunjung</given-names></name><xref ref-type="aff" rid="A36">36</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Jingmei</given-names></name><xref ref-type="aff" rid="A29">29</xref></contrib><contrib contrib-type="author"><name><surname>Lindblom</surname><given-names>Annika</given-names></name><xref ref-type="aff" rid="A68">68</xref></contrib><contrib contrib-type="author"><name><surname>Lophatananon</surname><given-names>Artitaya</given-names></name><xref ref-type="aff" rid="A69">69</xref></contrib><contrib contrib-type="author"><name><surname>Luben</surname><given-names>Robert</given-names></name><xref ref-type="aff" rid="A70">70</xref></contrib><contrib contrib-type="author"><name><surname>Lubinski</surname><given-names>Jan</given-names></name><xref ref-type="aff" rid="A57">57</xref></contrib><contrib contrib-type="author"><name><surname>Malone</surname><given-names>Kathleen E.</given-names></name><xref ref-type="aff" rid="A71">71</xref></contrib><contrib contrib-type="author"><name><surname>Mannermaa</surname><given-names>Arto</given-names></name><xref ref-type="aff" rid="A63">63</xref><xref ref-type="aff" rid="A64">64</xref><xref ref-type="aff" rid="A65">65</xref></contrib><contrib contrib-type="author"><name><surname>Manoukian</surname><given-names>Siranoush</given-names></name><xref ref-type="aff" rid="A72">72</xref></contrib><contrib contrib-type="author"><name><surname>Margolin</surname><given-names>Sara</given-names></name><xref ref-type="aff" rid="A73">73</xref></contrib><contrib contrib-type="author"><name><surname>Marme</surname><given-names>Frederik</given-names></name><xref ref-type="aff" rid="A74">74</xref><xref ref-type="aff" rid="A75">75</xref></contrib><contrib contrib-type="author"><name><surname>McLean</surname><given-names>Catriona</given-names></name><xref ref-type="aff" rid="A76">76</xref></contrib><contrib contrib-type="author"><name><surname>Meijers-Heijboer</surname><given-names>Hanne</given-names></name><xref ref-type="aff" rid="A77">77</xref></contrib><contrib contrib-type="author"><name><surname>Meindl</surname><given-names>Alfons</given-names></name><xref ref-type="aff" rid="A78">78</xref></contrib><contrib contrib-type="author"><name><surname>Miao</surname><given-names>Hui</given-names></name><xref ref-type="aff" rid="A55">55</xref></contrib><contrib contrib-type="author"><name><surname>Muir</surname><given-names>Kenneth</given-names></name><xref ref-type="aff" rid="A69">69</xref><xref ref-type="aff" rid="A79">79</xref></contrib><contrib contrib-type="author"><name><surname>Neuhausen</surname><given-names>Susan L.</given-names></name><xref ref-type="aff" rid="A80">80</xref></contrib><contrib contrib-type="author"><name><surname>Nevanlinna</surname><given-names>Heli</given-names></name><xref ref-type="aff" rid="A60">60</xref></contrib><contrib contrib-type="author"><name><surname>Neven</surname><given-names>Patrick</given-names></name><xref ref-type="aff" rid="A81">81</xref></contrib><contrib contrib-type="author"><name><surname>Olson</surname><given-names>Janet E.</given-names></name><xref ref-type="aff" rid="A82">82</xref></contrib><contrib contrib-type="author"><name><surname>Perkins</surname><given-names>Barbara</given-names></name><xref ref-type="aff" rid="A83">83</xref></contrib><contrib contrib-type="author"><name><surname>Peterlongo</surname><given-names>Paolo</given-names></name><xref ref-type="aff" rid="A84">84</xref></contrib><contrib contrib-type="author"><name><surname>Phillips</surname><given-names>Kelly-Anne</given-names></name><xref ref-type="aff" rid="A85">85</xref><xref ref-type="aff" rid="A86">86</xref><xref ref-type="aff" rid="A87">87</xref></contrib><contrib contrib-type="author"><name><surname>Pylkäs</surname><given-names>Katri</given-names></name><xref ref-type="aff" rid="A88">88</xref></contrib><contrib contrib-type="author"><name><surname>Rudolph</surname><given-names>Anja</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Santella</surname><given-names>Regina</given-names></name><xref ref-type="aff" rid="A89">89</xref><xref ref-type="aff" rid="A90">90</xref></contrib><contrib contrib-type="author"><name><surname>Sawyer</surname><given-names>Elinor J.</given-names></name><xref ref-type="aff" rid="A91">91</xref></contrib><contrib contrib-type="author"><name><surname>Schmutzler</surname><given-names>Rita K.</given-names></name><xref ref-type="aff" rid="A92">92</xref><xref ref-type="aff" rid="A93">93</xref><xref ref-type="aff" rid="A94">94</xref><xref ref-type="aff" rid="A95">95</xref></contrib><contrib contrib-type="author"><name><surname>Schoemaker</surname><given-names>Minouk</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Shah</surname><given-names>Mitul</given-names></name><xref ref-type="aff" rid="A83">83</xref></contrib><contrib contrib-type="author"><name><surname>Shrubsole</surname><given-names>Martha</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Southey</surname><given-names>Melissa C.</given-names></name><xref ref-type="aff" rid="A96">96</xref></contrib><contrib contrib-type="author"><name><surname>Swerdlow</surname><given-names>Anthony J</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A97">97</xref></contrib><contrib contrib-type="author"><name><surname>Toland</surname><given-names>Amanda E.</given-names></name><xref ref-type="aff" rid="A98">98</xref></contrib><contrib contrib-type="author"><name><surname>Tomlinson</surname><given-names>Ian</given-names></name><xref ref-type="aff" rid="A99">99</xref></contrib><contrib contrib-type="author"><name><surname>Torres</surname><given-names>Diana</given-names></name><xref ref-type="aff" rid="A53">53</xref></contrib><contrib contrib-type="author"><name><surname>Truong</surname><given-names>Thérèse</given-names></name><xref ref-type="aff" rid="A50">50</xref><xref ref-type="aff" rid="A51">51</xref></contrib><contrib contrib-type="author"><name><surname>Ursin</surname><given-names>Giske</given-names></name><xref ref-type="aff" rid="A100">100</xref><xref ref-type="aff" rid="A106">106</xref></contrib><contrib contrib-type="author"><name><surname>Van Der Luijt</surname><given-names>Rob B.</given-names></name><xref ref-type="aff" rid="A101">101</xref></contrib><contrib contrib-type="author"><name><surname>Verhoef</surname><given-names>Senno</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Wang-Gohrke</surname><given-names>Shan</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Whittemore</surname><given-names>Alice S.</given-names></name><xref ref-type="aff" rid="A59">59</xref></contrib><contrib contrib-type="author"><name><surname>Winqvist</surname><given-names>Robert</given-names></name><xref ref-type="aff" rid="A88">88</xref><xref ref-type="aff" rid="A102">102</xref></contrib><contrib contrib-type="author"><name><surname>Zamora</surname><given-names>M. Pilar</given-names></name><xref ref-type="aff" rid="A103">103</xref></contrib><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>Hui</given-names></name><xref ref-type="aff" rid="A104">104</xref><xref ref-type="aff" rid="A105">105</xref></contrib><contrib contrib-type="author"><name><surname>Dunning</surname><given-names>Alison M.</given-names></name><xref ref-type="aff" rid="A83">83</xref></contrib><contrib contrib-type="author"><name><surname>Simard</surname><given-names>Jacques</given-names></name><xref ref-type="aff" rid="A42">42</xref></contrib><contrib contrib-type="author"><name><surname>Hall</surname><given-names>Per</given-names></name><xref ref-type="aff" rid="A29">29</xref></contrib><contrib contrib-type="author"><name><surname>Kraft</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="A11">11</xref><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Pharoah</surname><given-names>Paul</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A83">83</xref></contrib><contrib contrib-type="author"><name><surname>Hunter</surname><given-names>David</given-names></name><xref ref-type="aff" rid="A11">11</xref><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Easton</surname><given-names>Douglas F.</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A83">83</xref></contrib><contrib contrib-type="author"><name><surname>Zheng</surname><given-names>Wei</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</aff><aff id="A2"><label>2</label>Division of Cancer Biostatistics, Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA</aff><aff id="A3"><label>3</label>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</aff><aff id="A4"><label>4</label>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</aff><aff id="A5"><label>5</label>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</aff><aff id="A6"><label>6</label>Centre for Epidemiology and Biostatistics, School of Population and Global health, The University of Melbourne, Melbourne, Australia</aff><aff id="A7"><label>7</label>Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK</aff><aff id="A8"><label>8</label>Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK</aff><aff id="A9"><label>9</label>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany</aff><aff id="A10"><label>10</label>Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany</aff><aff id="A11"><label>11</label>Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, MA, USA</aff><aff id="A12"><label>12</label>Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</aff><aff id="A13"><label>13</label>Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</aff><aff id="A14"><label>14</label>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</aff><aff id="A15"><label>15</label>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</aff><aff id="A16"><label>16</label>Department of Health Studies, The University of Chicago, Chicago, IL, USA</aff><aff id="A17"><label>17</label>Department of Clinical Genetics, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland</aff><aff id="A18"><label>18</label>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</aff><aff id="A19"><label>19</label>Department of Molecular Genetics, University of Toronto, Toronto, Canada</aff><aff id="A20"><label>20</label>Department of Epidemiology, University of California Irvine, Irvine, CA, USA</aff><aff id="A21"><label>21</label>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</aff><aff id="A22"><label>22</label>Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany</aff><aff id="A23"><label>23</label>Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain</aff><aff id="A24"><label>24</label>Centro de Investigación en Red de Enfermedades Raras, Valencia, Spain</aff><aff id="A25"><label>25</label>Department of Oncology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland</aff><aff id="A26"><label>26</label>Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</aff><aff id="A27"><label>27</label>Department of Genetics, Institute for Cancer Research, Radium hospitalet, Oslo University Hospital, Oslo University Hospital, Oslo, Norway</aff><aff id="A28"><label>28</label>K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway</aff><aff id="A29"><label>29</label>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A30"><label>30</label>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany</aff><aff id="A31"><label>31</label>University of Tübingen, Tübingen, Germany</aff><aff id="A32"><label>32</label>German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany</aff><aff id="A33"><label>33</label>Division of Preventive Oncology, German Cancer Research Center, Heidelberg, Germany</aff><aff id="A34"><label>34</label>Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany</aff><aff id="A35"><label>35</label>Molecular Epidemiology Group, German Cancer Research Center, Heidelberg, Germany</aff><aff id="A36"><label>36</label>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</aff><aff id="A37"><label>37</label>Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia</aff><aff id="A38"><label>38</label>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA</aff><aff id="A39"><label>39</label>Sheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield, UK</aff><aff id="A40"><label>40</label>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK</aff><aff id="A41"><label>41</label>Gynaecology Research Unit, Hannover Medical School, Hannover, Germany</aff><aff id="A42"><label>42</label>Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Canada</aff><aff id="A43"><label>43</label>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA, USA</aff><aff id="A44"><label>44</label>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA</aff><aff id="A45"><label>45</label>Institute for Medical Biometrics and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany</aff><aff id="A46"><label>46</label>Department of Cancer Epidemiology, Clinical Cancer Registry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany</aff><aff id="A47"><label>47</label>Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</aff><aff id="A48"><label>48</label>Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research "Demokritos", Athens, Greece</aff><aff id="A49"><label>49</label>Departments of Epidemiology, University of North Carolina Chapel-Hill, Chapel Hill, NC, USA</aff><aff id="A50"><label>50</label>Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 94807, Villejuif, France</aff><aff id="A51"><label>51</label>University Paris-Sud, UMRS 1018, 94807, Villejuif, France</aff><aff id="A52"><label>52</label>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</aff><aff id="A53"><label>53</label>Molecular Genetics of Breast Cancer, German Cancer Research Center, Heidelberg, Germany</aff><aff id="A54"><label>54</label>Department of Oncology, University of Cambridge, Strange ways Research Laboratory, Cambridge, UK</aff><aff id="A55"><label>55</label>Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore</aff><aff id="A56"><label>56</label>Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands</aff><aff id="A57"><label>57</label>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</aff><aff id="A58"><label>58</label>Cancer Prevention Institute of California, Fremont, CA, USA</aff><aff id="A59"><label>59</label>Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA</aff><aff id="A60"><label>60</label>Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland</aff><aff id="A61"><label>61</label>Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</aff><aff id="A62"><label>62</label>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada</aff><aff id="A63"><label>63</label>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</aff><aff id="A64"><label>64</label>Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</aff><aff id="A65"><label>65</label>Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland</aff><aff id="A66"><label>66</label>Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo, Norway</aff><aff id="A67"><label>67</label>University of Hawaii Cancer Center, Honolulu, HI, USA</aff><aff id="A68"><label>68</label>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A69"><label>69</label>Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK</aff><aff id="A70"><label>70</label>Clinical Gerontology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</aff><aff id="A71"><label>71</label>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA</aff><aff id="A72"><label>72</label>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy</aff><aff id="A73"><label>73</label>Department of Oncology - Pathology, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A74"><label>74</label>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</aff><aff id="A75"><label>75</label>National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</aff><aff id="A76"><label>76</label>Anatomical Pathology, The Alfred Hospital, Melbourne, Australia</aff><aff id="A77"><label>77</label>Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands</aff><aff id="A78"><label>78</label>Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany</aff><aff id="A79"><label>79</label>Institute of Population Health, University of Manchester, Manchester, UK</aff><aff id="A80"><label>80</label>Beckman Research Institute of City of Hope, Duarte, CA, USA</aff><aff id="A81"><label>81</label>Multidisciplinary Breast Centre and Gynaecological Oncology, KU Leuven - University of Leuven, University Hospitals Leuven, Department of Oncology, B-3000 Leuven, Belgium</aff><aff id="A82"><label>82</label>Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</aff><aff id="A83"><label>83</label>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</aff><aff id="A84"><label>84</label>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</aff><aff id="A85"><label>85</label>Peter MacCallum Cancer Center, The University of Melbourne, Melbourne, Australia</aff><aff id="A86"><label>86</label>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Australia</aff><aff id="A87"><label>87</label>Department of Medicine, St Vincent’s Hospital, The University of Melbourne, Fitzroy, Australia</aff><aff id="A88"><label>88</label>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu, Finland</aff><aff id="A89"><label>89</label>Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, USA</aff><aff id="A90"><label>90</label>Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, New York, NY, USA</aff><aff id="A91"><label>91</label>Research Oncology, Guy’s Hospital, King's College London, London, UK</aff><aff id="A92"><label>92</label>Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, Germany</aff><aff id="A93"><label>93</label>Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany</aff><aff id="A94"><label>94</label>Center for Molecular Medicine, University Hospital of Cologne, Cologne, Germany</aff><aff id="A95"><label>95</label>Center of Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany</aff><aff id="A96"><label>96</label>Department of Pathology, The University of Melbourne, Melbourne, Australia</aff><aff id="A97"><label>97</label>Division of Breast Cancer Research, Institute of Cancer Research, London, UK</aff><aff id="A98"><label>98</label>Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA</aff><aff id="A99"><label>99</label>Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford, UK</aff><aff id="A100"><label>100</label>Cancer Registry of Norway, Oslo, Norway</aff><aff id="A101"><label>101</label>Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</aff><aff id="A102"><label>102</label>Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland</aff><aff id="A103"><label>103</label>Servicio de Oncología Médica, Hospital Universitario La Paz, Madrid, Spain</aff><aff id="A104"><label>104</label>Vesalius Research Center, Leuven, Belgium</aff><aff id="A105"><label>105</label>Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium</aff><aff id="A106"><label>106</label>Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway</aff><author-notes><corresp id="cor1"><bold>Correspondence:</bold> Wei Zheng, MD, PhD, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, 2525 West End Avenue, 8th Floor, Nashville, TN 37203-1738, USA, Phone: (615) 936-0682; Fax: (615) 936-8241, <email>wei.zheng@vanderbilt.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>16</day><month>9</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>06</day><month>4</month><year>2016</year></pub-date><pub-date pub-type="ppub"><month>5</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>5</month><year>2017</year></pub-date><volume>27</volume><issue>5</issue><fpage>679</fpage><lpage>693</lpage><pmc-comment>elocation-id from pubmed: 10.1007/s10552-016-0741-6</pmc-comment>
<abstract><sec id="S1"><title>Purpose</title><p id="P1">Type 2 diabetes (T2D) has been reported to be associated with an elevated risk of breast cancer. It is unclear, however, whether this association is due to shared genetic factors.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We constructed a genetic risk score (GRS) using risk variants from 33 known independent T2D susceptibility loci and evaluated its relation to breast cancer risk using the data from two consortia, including 62,328 breast cancer patients and 83,817 controls of European ancestry. Unconditional logistic regression models were used to derive adjusted odds ratios (OR) and 95% confidence intervals (CI) to measure the association of breast cancer risk with T2D GRS or T2D-associated genetic risk variants. Meta-analyses were conducted to obtain summary ORs across all studies.</p></sec><sec id="S3"><title>Results</title><p id="P3">The T2D GRS was not found to be associated with breast cancer risk, overall, by menopausal status, or for estrogen receptor positive or negative breast cancer. Three T2D associated risk variants were individually associated with breast cancer risk after adjustment for multiple comparisons using the Bonferroni method (at <italic>P</italic> < 0.001), rs9939609 (<italic>FTO</italic>) (OR = 0.94, 95% CI = 0.92 – 0.95, <italic>P</italic> = 4.13E-13), rs7903146 (<italic>TCF7L2</italic>) (OR = 1.04, 95% CI = 1.02 – 1.06, <italic>P</italic> = 1.26E-05), and rs8042680 (<italic>PRC1</italic>) (OR = 0.97, 95% CI = 0.95 – 0.99, <italic>P</italic> = 8.05E-04).</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">We have shown that several genetic risk variants were associated with the risk of both T2D and breast cancer. However, overall genetic susceptibility to T2D may not be related to breast cancer risk.</p></sec></abstract><kwd-group><kwd>type 2 diabetes</kwd><kwd>genetic susceptibility</kwd><kwd>GWAS</kwd><kwd>breast cancer</kwd><kwd>epidemiology</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002073 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 002073 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.33. |  |