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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Feasibility and Domain Validation of RA Flare Core Domain Set: A Report of the OMERACT 2014 RA Flare Group Plenary</title><author><name sortKey="Bartlett, Susan J" sort="Bartlett, Susan J" uniqKey="Bartlett S" first="Susan J." last="Bartlett">Susan J. Bartlett</name><affiliation><nlm:aff id="A1">McGill University, Montreal, CA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Johns Hopkins University, Baltimore USA</nlm:aff></affiliation></author><author><name sortKey="Bykerk, Vivian P" sort="Bykerk, Vivian P" uniqKey="Bykerk V" first="Vivian P." last="Bykerk">Vivian P. Bykerk</name><affiliation><nlm:aff id="A3">Hospital for Special Surgery, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Cooksey, Roxanne" sort="Cooksey, Roxanne" uniqKey="Cooksey R" first="Roxanne" last="Cooksey">Roxanne Cooksey</name><affiliation><nlm:aff id="A4">Swansea University, Swansea, UK</nlm:aff></affiliation></author><author><name sortKey="Choy, Ernest H" sort="Choy, Ernest H" uniqKey="Choy E" first="Ernest H." last="Choy">Ernest H. Choy</name><affiliation><nlm:aff id="A5">Cardiff University, Cardiff, UK</nlm:aff></affiliation></author><author><name sortKey="Alten, Rieke" sort="Alten, Rieke" uniqKey="Alten R" first="Rieke" last="Alten">Rieke Alten</name><affiliation><nlm:aff id="A6">Schlosspark-Klinik, University Medicine Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Christensen, Robin" sort="Christensen, Robin" uniqKey="Christensen R" first="Robin" last="Christensen">Robin Christensen</name><affiliation><nlm:aff id="A7">The Parker Institute, Copenhagen University Hospital at Frederiksberg, Copenhagen F, Denmark</nlm:aff></affiliation></author><author><name sortKey="Furst, Daniel E" sort="Furst, Daniel E" uniqKey="Furst D" first="Daniel E." last="Furst">Daniel E. Furst</name><affiliation><nlm:aff id="A8">University of California, Los Angeles, USA</nlm:aff></affiliation></author><author><name sortKey="Guillemin, Francis" sort="Guillemin, Francis" uniqKey="Guillemin F" first="Francis" last="Guillemin">Francis Guillemin</name><affiliation><nlm:aff id="A9">University of Lorraine, Nancy, France</nlm:aff></affiliation></author><author><name sortKey="Halls, Serena" sort="Halls, Serena" uniqKey="Halls S" first="Serena" last="Halls">Serena Halls</name><affiliation><nlm:aff id="A10">University of the West of England, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Hewlett, Sarah" sort="Hewlett, Sarah" uniqKey="Hewlett S" first="Sarah" last="Hewlett">Sarah Hewlett</name><affiliation><nlm:aff id="A10">University of the West of England, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Leong, Amye L" sort="Leong, Amye L" uniqKey="Leong A" first="Amye L." last="Leong">Amye L. Leong</name><affiliation><nlm:aff id="A11">Healthy Motivation, Santa Barbara, USA</nlm:aff></affiliation></author><author><name sortKey="Lyddiatt, Anne" sort="Lyddiatt, Anne" uniqKey="Lyddiatt A" first="Anne" last="Lyddiatt">Anne Lyddiatt</name></author><author><name sortKey="March, Lyn" sort="March, Lyn" uniqKey="March L" first="Lyn" last="March">Lyn March</name><affiliation><nlm:aff id="A12">University of Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Montie, Pamela" sort="Montie, Pamela" uniqKey="Montie P" first="Pamela" last="Montie">Pamela Montie</name></author><author><name sortKey="Orbai, Ana Maria" sort="Orbai, Ana Maria" uniqKey="Orbai A" first="Ana Maria" last="Orbai">Ana Maria Orbai</name><affiliation><nlm:aff id="A2">Johns Hopkins University, Baltimore USA</nlm:aff></affiliation></author><author><name sortKey="Pohl, Christoph" sort="Pohl, Christoph" uniqKey="Pohl C" first="Christoph" last="Pohl">Christoph Pohl</name><affiliation><nlm:aff id="A6">Schlosspark-Klinik, University Medicine Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Voshaar, Marieke Scholte" sort="Voshaar, Marieke Scholte" uniqKey="Voshaar M" first="Marieke Scholte" last="Voshaar">Marieke Scholte Voshaar</name><affiliation><nlm:aff id="A13">University of Twente, Enschede, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Woodworth, Thasia G" sort="Woodworth, Thasia G" uniqKey="Woodworth T" first="Thasia G." last="Woodworth">Thasia G. Woodworth</name><affiliation><nlm:aff id="A8">University of California, Los Angeles, USA</nlm:aff></affiliation></author><author><name sortKey="Bingham, Clifton O" sort="Bingham, Clifton O" uniqKey="Bingham C" first="Clifton O." last="Bingham">Clifton O. Bingham</name><affiliation><nlm:aff id="A2">Johns Hopkins University, Baltimore USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25684764</idno><idno type="pmc">4747421</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747421</idno><idno type="RBID">PMC:4747421</idno><idno type="doi">10.3899/jrheum.141169</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">001F46</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001F46</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Feasibility and Domain Validation of RA Flare Core Domain Set: A Report of the OMERACT 2014 RA Flare Group Plenary</title><author><name sortKey="Bartlett, Susan J" sort="Bartlett, Susan J" uniqKey="Bartlett S" first="Susan J." last="Bartlett">Susan J. Bartlett</name><affiliation><nlm:aff id="A1">McGill University, Montreal, CA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Johns Hopkins University, Baltimore USA</nlm:aff></affiliation></author><author><name sortKey="Bykerk, Vivian P" sort="Bykerk, Vivian P" uniqKey="Bykerk V" first="Vivian P." last="Bykerk">Vivian P. Bykerk</name><affiliation><nlm:aff id="A3">Hospital for Special Surgery, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Cooksey, Roxanne" sort="Cooksey, Roxanne" uniqKey="Cooksey R" first="Roxanne" last="Cooksey">Roxanne Cooksey</name><affiliation><nlm:aff id="A4">Swansea University, Swansea, UK</nlm:aff></affiliation></author><author><name sortKey="Choy, Ernest H" sort="Choy, Ernest H" uniqKey="Choy E" first="Ernest H." last="Choy">Ernest H. Choy</name><affiliation><nlm:aff id="A5">Cardiff University, Cardiff, UK</nlm:aff></affiliation></author><author><name sortKey="Alten, Rieke" sort="Alten, Rieke" uniqKey="Alten R" first="Rieke" last="Alten">Rieke Alten</name><affiliation><nlm:aff id="A6">Schlosspark-Klinik, University Medicine Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Christensen, Robin" sort="Christensen, Robin" uniqKey="Christensen R" first="Robin" last="Christensen">Robin Christensen</name><affiliation><nlm:aff id="A7">The Parker Institute, Copenhagen University Hospital at Frederiksberg, Copenhagen F, Denmark</nlm:aff></affiliation></author><author><name sortKey="Furst, Daniel E" sort="Furst, Daniel E" uniqKey="Furst D" first="Daniel E." last="Furst">Daniel E. Furst</name><affiliation><nlm:aff id="A8">University of California, Los Angeles, USA</nlm:aff></affiliation></author><author><name sortKey="Guillemin, Francis" sort="Guillemin, Francis" uniqKey="Guillemin F" first="Francis" last="Guillemin">Francis Guillemin</name><affiliation><nlm:aff id="A9">University of Lorraine, Nancy, France</nlm:aff></affiliation></author><author><name sortKey="Halls, Serena" sort="Halls, Serena" uniqKey="Halls S" first="Serena" last="Halls">Serena Halls</name><affiliation><nlm:aff id="A10">University of the West of England, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Hewlett, Sarah" sort="Hewlett, Sarah" uniqKey="Hewlett S" first="Sarah" last="Hewlett">Sarah Hewlett</name><affiliation><nlm:aff id="A10">University of the West of England, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Leong, Amye L" sort="Leong, Amye L" uniqKey="Leong A" first="Amye L." last="Leong">Amye L. Leong</name><affiliation><nlm:aff id="A11">Healthy Motivation, Santa Barbara, USA</nlm:aff></affiliation></author><author><name sortKey="Lyddiatt, Anne" sort="Lyddiatt, Anne" uniqKey="Lyddiatt A" first="Anne" last="Lyddiatt">Anne Lyddiatt</name></author><author><name sortKey="March, Lyn" sort="March, Lyn" uniqKey="March L" first="Lyn" last="March">Lyn March</name><affiliation><nlm:aff id="A12">University of Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Montie, Pamela" sort="Montie, Pamela" uniqKey="Montie P" first="Pamela" last="Montie">Pamela Montie</name></author><author><name sortKey="Orbai, Ana Maria" sort="Orbai, Ana Maria" uniqKey="Orbai A" first="Ana Maria" last="Orbai">Ana Maria Orbai</name><affiliation><nlm:aff id="A2">Johns Hopkins University, Baltimore USA</nlm:aff></affiliation></author><author><name sortKey="Pohl, Christoph" sort="Pohl, Christoph" uniqKey="Pohl C" first="Christoph" last="Pohl">Christoph Pohl</name><affiliation><nlm:aff id="A6">Schlosspark-Klinik, University Medicine Berlin, Germany</nlm:aff></affiliation></author><author><name sortKey="Voshaar, Marieke Scholte" sort="Voshaar, Marieke Scholte" uniqKey="Voshaar M" first="Marieke Scholte" last="Voshaar">Marieke Scholte Voshaar</name><affiliation><nlm:aff id="A13">University of Twente, Enschede, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Woodworth, Thasia G" sort="Woodworth, Thasia G" uniqKey="Woodworth T" first="Thasia G." last="Woodworth">Thasia G. Woodworth</name><affiliation><nlm:aff id="A8">University of California, Los Angeles, USA</nlm:aff></affiliation></author><author><name sortKey="Bingham, Clifton O" sort="Bingham, Clifton O" uniqKey="Bingham C" first="Clifton O." last="Bingham">Clifton O. Bingham</name><affiliation><nlm:aff id="A2">Johns Hopkins University, Baltimore USA</nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of rheumatology</title><idno type="ISSN">0315-162X</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P1">The OMERACT RA Flare Group was established to develop an approach to identify and measure rheumatoid arthritis (RA) flares. Here, we provide an overview of our OMERACT 2014 plenary.</p></sec><sec id="S2"><title>Methods</title><p id="P2">Feasibility and validity of flare domains endorsed at OMERACT 11 (2012) were described based on initial data from three international studies collected using a common set of questions specific to RA flare. Mean flare frequency, severity, and duration data were presented, and domain scores were compared by flare status to examine known-groups validity. Breakout groups provided input for stiffness, self-management, contextual factors, and measurement considerations.</p></sec><sec id="S3"><title>Results</title><p id="P3">Flare data from 501 patients in a observational study indicated 39% were in a flare, with mean (SD) severity of 6.0 (2.6) and 55% lasting > 14 days. Pain, physical function, fatigue, participation and stiffness scores averaged ≥ 2 times higher (2 of 11 points) in flaring individuals. Correlations between flare domains and corresponding legacy instruments were r’s from 0.46 to 0.93. A combined definition (patient-report of flare and DAS28 increase) was evaluated in two other trials with similar results. Breakout groups debated specific measurement issues.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">These data contribute initial evidence of feasibility and content validation of the OMERACT RA Flare Core Domain Set. Our research agenda for OMERACT 2016 includes establishing duration/intensity criteria and developing criteria to identify RA flares using existing disease activity measures. Ongoing work will also address discordance between patients and physician ratings, facilitate applications to clinical care, elucidate the role of self-management and help finalize recommendations for RA flare measurement.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7501984</journal-id><journal-id journal-id-type="pubmed-jr-id">5243</journal-id><journal-id journal-id-type="nlm-ta">J Rheumatol</journal-id><journal-id journal-id-type="iso-abbrev">J. Rheumatol.</journal-id><journal-title-group><journal-title>The Journal of rheumatology</journal-title></journal-title-group><issn pub-type="ppub">0315-162X</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25684764</article-id><article-id pub-id-type="pmc">4747421</article-id><article-id pub-id-type="doi">10.3899/jrheum.141169</article-id><article-id pub-id-type="manuscript">NIHMS682567</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Feasibility and Domain Validation of RA Flare Core Domain Set: A Report of the OMERACT 2014 RA Flare Group Plenary</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Bartlett</surname><given-names>Susan J.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Bykerk</surname><given-names>Vivian P.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Cooksey</surname><given-names>Roxanne</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Choy</surname><given-names>Ernest H.</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Alten</surname><given-names>Rieke</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Christensen</surname><given-names>Robin</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Furst</surname><given-names>Daniel E.</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Guillemin</surname><given-names>Francis</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Halls</surname><given-names>Serena</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Hewlett</surname><given-names>Sarah</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Leong</surname><given-names>Amye L.</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Lyddiatt</surname><given-names>Anne</given-names></name></contrib><contrib contrib-type="author"><name><surname>March</surname><given-names>Lyn</given-names></name><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Montie</surname><given-names>Pamela</given-names></name></contrib><contrib contrib-type="author"><name><surname>Orbai</surname><given-names>Ana Maria</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Pohl</surname><given-names>Christoph</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Voshaar</surname><given-names>Marieke Scholte</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Woodworth</surname><given-names>Thasia G.</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Bingham</surname><given-names>Clifton O.</given-names><suffix>III</suffix></name><xref ref-type="aff" rid="A2">2</xref></contrib></contrib-group><aff id="A1"><label>1</label>McGill University, Montreal, CA</aff><aff id="A2"><label>2</label>Johns Hopkins University, Baltimore USA</aff><aff id="A3"><label>3</label>Hospital for Special Surgery, New York, USA</aff><aff id="A4"><label>4</label>Swansea University, Swansea, UK</aff><aff id="A5"><label>5</label>Cardiff University, Cardiff, UK</aff><aff id="A6"><label>6</label>Schlosspark-Klinik, University Medicine Berlin, Germany</aff><aff id="A7"><label>7</label>The Parker Institute, Copenhagen University Hospital at Frederiksberg, Copenhagen F, Denmark</aff><aff id="A8"><label>8</label>University of California, Los Angeles, USA</aff><aff id="A9"><label>9</label>University of Lorraine, Nancy, France</aff><aff id="A10"><label>10</label>University of the West of England, Bristol, UK</aff><aff id="A11"><label>11</label>Healthy Motivation, Santa Barbara, USA</aff><aff id="A12"><label>12</label>University of Sydney, Australia</aff><aff id="A13"><label>13</label>University of Twente, Enschede, The Netherlands</aff><author-notes><corresp id="cor1">Corresponding Author: Susan J Bartlett PhD, Royal Victoria Hospital, Dept. of Clinical Epidemiology, 687 av des Pin Ouest, Montréal, QC, H3A 1A1, <email>Susan.bartlett@mcgill.ca</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>23</day><month>10</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>15</day><month>2</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>11</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>09</day><month>2</month><year>2016</year></pub-date><volume>42</volume><issue>11</issue><fpage>2185</fpage><lpage>2189</lpage><pmc-comment>elocation-id from pubmed: 10.3899/jrheum.141169</pmc-comment>
<abstract><sec id="S1"><title>Objective</title><p id="P1">The OMERACT RA Flare Group was established to develop an approach to identify and measure rheumatoid arthritis (RA) flares. Here, we provide an overview of our OMERACT 2014 plenary.</p></sec><sec id="S2"><title>Methods</title><p id="P2">Feasibility and validity of flare domains endorsed at OMERACT 11 (2012) were described based on initial data from three international studies collected using a common set of questions specific to RA flare. Mean flare frequency, severity, and duration data were presented, and domain scores were compared by flare status to examine known-groups validity. Breakout groups provided input for stiffness, self-management, contextual factors, and measurement considerations.</p></sec><sec id="S3"><title>Results</title><p id="P3">Flare data from 501 patients in a observational study indicated 39% were in a flare, with mean (SD) severity of 6.0 (2.6) and 55% lasting > 14 days. Pain, physical function, fatigue, participation and stiffness scores averaged ≥ 2 times higher (2 of 11 points) in flaring individuals. Correlations between flare domains and corresponding legacy instruments were r’s from 0.46 to 0.93. A combined definition (patient-report of flare and DAS28 increase) was evaluated in two other trials with similar results. Breakout groups debated specific measurement issues.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">These data contribute initial evidence of feasibility and content validation of the OMERACT RA Flare Core Domain Set. Our research agenda for OMERACT 2016 includes establishing duration/intensity criteria and developing criteria to identify RA flares using existing disease activity measures. Ongoing work will also address discordance between patients and physician ratings, facilitate applications to clinical care, elucidate the role of self-management and help finalize recommendations for RA flare measurement.</p></sec></abstract><kwd-group><title>Key indexing terms</title><kwd>flare</kwd><kwd>disease exacerbation</kwd><kwd>rheumatoid arthritis</kwd><kwd>OMERACT</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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