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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The 19q12 bladder cancer GWAS signal: association with cyclin E function and aggressive disease</title><author><name sortKey="Fu, Yi Ping" sort="Fu, Yi Ping" uniqKey="Fu Y" first="Yi-Ping" last="Fu">Yi-Ping Fu</name><affiliation><nlm:aff id="A1">Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Kohaar, Indu" sort="Kohaar, Indu" uniqKey="Kohaar I" first="Indu" last="Kohaar">Indu Kohaar</name><affiliation><nlm:aff id="A1">Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Moore, Lee E" sort="Moore, Lee E" uniqKey="Moore L" first="Lee E." last="Moore">Lee E. Moore</name><affiliation><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Lenz, Petra" sort="Lenz, Petra" uniqKey="Lenz P" first="Petra" last="Lenz">Petra Lenz</name><affiliation><nlm:aff id="A3">Clinical Research Directorate/Clinical Monitoring Research Program, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Figueroa, Jonine D" sort="Figueroa, Jonine D" uniqKey="Figueroa J" first="Jonine D." last="Figueroa">Jonine D. Figueroa</name><affiliation><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Tang, Wei" sort="Tang, Wei" uniqKey="Tang W" first="Wei" last="Tang">Wei Tang</name><affiliation><nlm:aff id="A1">Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Porter Gill, Patricia" sort="Porter Gill, Patricia" uniqKey="Porter Gill P" first="Patricia" last="Porter-Gill">Patricia Porter-Gill</name><affiliation><nlm:aff id="A1">Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Chatterjee, Nilanjan" sort="Chatterjee, Nilanjan" uniqKey="Chatterjee N" first="Nilanjan" last="Chatterjee">Nilanjan Chatterjee</name><affiliation><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Scott Johnson, Alexandra" sort="Scott Johnson, Alexandra" uniqKey="Scott Johnson A" first="Alexandra" last="Scott-Johnson">Alexandra Scott-Johnson</name><affiliation><nlm:aff id="A1">Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name><affiliation><nlm:aff id="A4">Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Muchmore, Brian" sort="Muchmore, Brian" uniqKey="Muchmore B" first="Brian" last="Muchmore">Brian Muchmore</name><affiliation><nlm:aff id="A1">Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Baris, Dalsu" sort="Baris, Dalsu" uniqKey="Baris D" first="Dalsu" last="Baris">Dalsu Baris</name><affiliation><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Paquin, Ashley" sort="Paquin, Ashley" uniqKey="Paquin A" first="Ashley" last="Paquin">Ashley Paquin</name><affiliation><nlm:aff id="A1">Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Ylaya, Kris" sort="Ylaya, Kris" uniqKey="Ylaya K" first="Kris" last="Ylaya">Kris Ylaya</name><affiliation><nlm:aff id="A5">Laboratory of Pathology, Center of Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Schwenn, Molly" sort="Schwenn, Molly" uniqKey="Schwenn M" first="Molly" last="Schwenn">Molly Schwenn</name><affiliation><nlm:aff id="A6">Maine Cancer Registry, Augusta, Maine, USA</nlm:aff></affiliation></author><author><name sortKey="Apolo, Andrea B" sort="Apolo, Andrea B" uniqKey="Apolo A" first="Andrea B." last="Apolo">Andrea B. Apolo</name><affiliation><nlm:aff id="A7">Genitourinary Malignancy Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Karagas, Margaret R" sort="Karagas, Margaret R" uniqKey="Karagas M" first="Margaret R." last="Karagas">Margaret R. Karagas</name><affiliation><nlm:aff id="A8">Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA</nlm:aff></affiliation></author><author><name sortKey="Tarway, Mcanthony" sort="Tarway, Mcanthony" uniqKey="Tarway M" first="Mcanthony" last="Tarway">Mcanthony Tarway</name><affiliation><nlm:aff id="A1">Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Johnson, Alison" sort="Johnson, Alison" uniqKey="Johnson A" first="Alison" last="Johnson">Alison Johnson</name><affiliation><nlm:aff id="A9">Vermont Cancer Registry, Burlington, Vermont, USA</nlm:aff></affiliation></author><author><name sortKey="Mumy, Adam" sort="Mumy, Adam" uniqKey="Mumy A" first="Adam" last="Mumy">Adam Mumy</name><affiliation><nlm:aff id="A1">Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Schned, Alan" sort="Schned, Alan" uniqKey="Schned A" first="Alan" last="Schned">Alan Schned</name><affiliation><nlm:aff id="A8">Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA</nlm:aff></affiliation></author><author><name sortKey="Guedez, Liliana" sort="Guedez, Liliana" uniqKey="Guedez L" first="Liliana" last="Guedez">Liliana Guedez</name><affiliation><nlm:aff id="A10">Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Jones, Michael A" sort="Jones, Michael A" uniqKey="Jones M" first="Michael A." last="Jones">Michael A. Jones</name><affiliation><nlm:aff id="A11">Department of Pathology and Laboratory Medicine, Maine Medical Center, Portland, Maine, USA</nlm:aff></affiliation></author><author><name sortKey="Kida, Masatoshi" sort="Kida, Masatoshi" uniqKey="Kida M" first="Masatoshi" last="Kida">Masatoshi Kida</name><affiliation><nlm:aff id="A12">Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont, USA</nlm:aff></affiliation></author><author><name sortKey="Monawar Hosain, Gm" sort="Monawar Hosain, Gm" uniqKey="Monawar Hosain G" first="Gm" last="Monawar Hosain">Gm Monawar Hosain</name><affiliation><nlm:aff id="A13">New Hampshire State Cancer Registry, Concord, New Hampshire, USA</nlm:aff></affiliation></author><author><name sortKey="Malats, Nuria" sort="Malats, Nuria" uniqKey="Malats N" first="Nuria" last="Malats">Nuria Malats</name><affiliation><nlm:aff id="A14">Spanish National Cancer Research Centre, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Kogevinas, Manolis" sort="Kogevinas, Manolis" uniqKey="Kogevinas M" first="Manolis" last="Kogevinas">Manolis Kogevinas</name><affiliation><nlm:aff id="A15">Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A17">National School of Public Health, Athens, Greece</nlm:aff></affiliation><affiliation><nlm:aff id="A18">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Tardon, Adonina" sort="Tardon, Adonina" uniqKey="Tardon A" first="Adonina" last="Tardon">Adonina Tardon</name><affiliation><nlm:aff id="A18">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A19">Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Spain</nlm:aff></affiliation></author><author><name sortKey="Serra, Consol" sort="Serra, Consol" uniqKey="Serra C" first="Consol" last="Serra">Consol Serra</name><affiliation><nlm:aff id="A18">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Universitat Pompeu Fabra, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Carrato, Alfredo" sort="Carrato, Alfredo" uniqKey="Carrato A" first="Alfredo" last="Carrato">Alfredo Carrato</name><affiliation><nlm:aff id="A21">Ramón y Cajal Hospital, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Reina" sort="Garcia Closas, Reina" uniqKey="Garcia Closas R" first="Reina" last="Garcia-Closas">Reina Garcia-Closas</name><affiliation><nlm:aff id="A22">Unidad de Investigación, Hospital Universitario de Canarias, La Laguna, Spain</nlm:aff></affiliation></author><author><name sortKey="Lloreta, Josep" sort="Lloreta, Josep" uniqKey="Lloreta J" first="Josep" last="Lloreta">Josep Lloreta</name><affiliation><nlm:aff id="A23">Hospital del Mar-IMIM, Univesitat Pompeu Fabra, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Wu, Xifeng" sort="Wu, Xifeng" uniqKey="Wu X" first="Xifeng" last="Wu">Xifeng Wu</name><affiliation><nlm:aff id="A24">Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA</nlm:aff></affiliation></author><author><name sortKey="Purdue, Mark" sort="Purdue, Mark" uniqKey="Purdue M" first="Mark" last="Purdue">Mark Purdue</name><affiliation><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Andriole, Gerald L" sort="Andriole, Gerald L" uniqKey="Andriole G" first="Gerald L." last="Andriole">Gerald L. Andriole</name><affiliation><nlm:aff id="A25">Division of Urologic Surgery, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff></affiliation></author><author><name sortKey="Grubb, Robert L" sort="Grubb, Robert L" uniqKey="Grubb R" first="Robert L." last="Grubb">Robert L. Grubb</name><affiliation><nlm:aff id="A25">Division of Urologic Surgery, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff></affiliation></author><author><name sortKey="Black, Amanda" sort="Black, Amanda" uniqKey="Black A" first="Amanda" last="Black">Amanda Black</name><affiliation><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Landi, Maria T" sort="Landi, Maria T" uniqKey="Landi M" first="Maria T." last="Landi">Maria T. Landi</name><affiliation><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Caporaso, Neil E" sort="Caporaso, Neil E" uniqKey="Caporaso N" first="Neil E." last="Caporaso">Neil E. Caporaso</name><affiliation><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name><affiliation><nlm:aff id="A26">School of Public Health, Imperial College London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Human Genetics Foundation (HuGeF), Torino, Italy</nlm:aff></affiliation></author><author><name sortKey="Siddiq, Afshan" sort="Siddiq, Afshan" uniqKey="Siddiq A" first="Afshan" last="Siddiq">Afshan Siddiq</name><affiliation><nlm:aff id="A26">School of Public Health, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H. Bas" last="Bueno-De-Mesquita">H. Bas Bueno-De-Mesquita</name><affiliation><nlm:aff id="A29">National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A67">Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A68">Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Trichopoulos, Dimitrios" sort="Trichopoulos, Dimitrios" uniqKey="Trichopoulos D" first="Dimitrios" last="Trichopoulos">Dimitrios Trichopoulos</name><affiliation><nlm:aff id="A31">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A32">Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Hellenic Health Foundation, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Ljungberg, Borje" sort="Ljungberg, Borje" uniqKey="Ljungberg B" first="Börje" last="Ljungberg">Börje Ljungberg</name><affiliation><nlm:aff id="A34">Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden</nlm:aff></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:aff id="A27">Human Genetics Foundation (HuGeF), Torino, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A35">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A36">Centre for Epidemiology and Biostatistics, University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name><affiliation><nlm:aff id="A37">Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Department of Research, Cancer Registry of Norway, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Samfundet Folkhälsan, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Krogh, Vittorio" sort="Krogh, Vittorio" uniqKey="Krogh V" first="Vittorio" last="Krogh">Vittorio Krogh</name><affiliation><nlm:aff id="A41">Fondazione IRCCS Istituto Nazionale dei Tumori - Milano, Italy</nlm:aff></affiliation></author><author><name sortKey="Dorronsoro, Miren" sort="Dorronsoro, Miren" uniqKey="Dorronsoro M" first="Miren" last="Dorronsoro">Miren Dorronsoro</name><affiliation><nlm:aff id="A42">Public Health Division of Gipuzkoa, Basque Regional Health Department and Ciberesp-Biodonostia, San Sebastian, Spain</nlm:aff></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name><affiliation><nlm:aff id="A43">Cancer Epidemiology Unit, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Tj Nneland, Anne" sort="Tj Nneland, Anne" uniqKey="Tj Nneland A" first="Anne" last="Tj Nneland">Anne Tj Nneland</name><affiliation><nlm:aff id="A44">Danish Cancer Society Research Center, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation><nlm:aff id="A45">International Agency for Research on Cancer, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="A46">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><affiliation><nlm:aff id="A26">School of Public Health, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Prescott, Jennifer" sort="Prescott, Jennifer" uniqKey="Prescott J" first="Jennifer" last="Prescott">Jennifer Prescott</name><affiliation><nlm:aff id="A47">Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Chen, Constance" sort="Chen, Constance" uniqKey="Chen C" first="Constance" last="Chen">Constance Chen</name><affiliation><nlm:aff id="A48">Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="De Vivo, Immaculata" sort="De Vivo, Immaculata" uniqKey="De Vivo I" first="Immaculata" last="De Vivo">Immaculata De Vivo</name><affiliation><nlm:aff id="A47">Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Govannucci, Edward" sort="Govannucci, Edward" uniqKey="Govannucci E" first="Edward" last="Govannucci">Edward Govannucci</name><affiliation><nlm:aff id="A49">Department of Nutrition and Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Hunter, David" sort="Hunter, David" uniqKey="Hunter D" first="David" last="Hunter">David Hunter</name><affiliation><nlm:aff id="A48">Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:aff id="A48">Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindstrom">Sara Lindstrom</name><affiliation><nlm:aff id="A48">Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Gapstur, Susan M" sort="Gapstur, Susan M" uniqKey="Gapstur S" first="Susan M." last="Gapstur">Susan M. Gapstur</name><affiliation><nlm:aff id="A50">Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</nlm:aff></affiliation></author><author><name sortKey="Jacobs, Eric J" sort="Jacobs, Eric J" uniqKey="Jacobs E" first="Eric J." last="Jacobs">Eric J. Jacobs</name><affiliation><nlm:aff id="A50">Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</nlm:aff></affiliation></author><author><name sortKey="Diver, W Ryan" sort="Diver, W Ryan" uniqKey="Diver W" first="W. Ryan" last="Diver">W. Ryan Diver</name><affiliation><nlm:aff id="A50">Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</nlm:aff></affiliation></author><author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name><affiliation><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Weinstein, Stephanie J" sort="Weinstein, Stephanie J" uniqKey="Weinstein S" first="Stephanie J." last="Weinstein">Stephanie J. Weinstein</name><affiliation><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name><affiliation><nlm:aff id="A51">National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Kooperberg, Charles" sort="Kooperberg, Charles" uniqKey="Kooperberg C" first="Charles" last="Kooperberg">Charles Kooperberg</name><affiliation><nlm:aff id="A52">Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Hohensee, Chancellor" sort="Hohensee, Chancellor" uniqKey="Hohensee C" first="Chancellor" last="Hohensee">Chancellor Hohensee</name><affiliation><nlm:aff id="A52">Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Rodabough, Rebecca J" sort="Rodabough, Rebecca J" uniqKey="Rodabough R" first="Rebecca J." last="Rodabough">Rebecca J. Rodabough</name><affiliation><nlm:aff id="A52">Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Cortessis, Victoria K" sort="Cortessis, Victoria K" uniqKey="Cortessis V" first="Victoria K." last="Cortessis">Victoria K. Cortessis</name><affiliation><nlm:aff id="A53">Department of Obstetrics & Gynecology, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A54">Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Conti, David V" sort="Conti, David V" uniqKey="Conti D" first="David V." last="Conti">David V. Conti</name><affiliation><nlm:aff id="A54">Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Gago Dominguez, Manuela" sort="Gago Dominguez, Manuela" uniqKey="Gago Dominguez M" first="Manuela" last="Gago-Dominguez">Manuela Gago-Dominguez</name><affiliation><nlm:aff id="A55">Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain</nlm:aff></affiliation></author><author><name sortKey="Stern, Mariana C" sort="Stern, Mariana C" uniqKey="Stern M" first="Mariana C." last="Stern">Mariana C. Stern</name><affiliation><nlm:aff id="A54">Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Pike, Malcolm C" sort="Pike, Malcolm C" uniqKey="Pike M" first="Malcolm C." last="Pike">Malcolm C. Pike</name><affiliation><nlm:aff id="A56">Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Van Den Berg, David" sort="Van Den Berg, David" uniqKey="Van Den Berg D" first="David" last="Van Den Berg">David Van Den Berg</name><affiliation><nlm:aff id="A54">Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Yuan, Jian Min" sort="Yuan, Jian Min" uniqKey="Yuan J" first="Jian-Min" last="Yuan">Jian-Min Yuan</name><affiliation><nlm:aff id="A57">University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff id="A54">Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Cussenot, Olivier" sort="Cussenot, Olivier" uniqKey="Cussenot O" first="Olivier" last="Cussenot">Olivier Cussenot</name><affiliation><nlm:aff id="A58">AP-HP, Hopital Tenon, GHU-Est, Department of Urology, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A59">Centre de Recherche sur les Pathologies Prostatiques, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A60">UPMC Univ Paris 06, GRC n°5, ONCOTYPE-URO, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Cancel Tassin, Geraldine" sort="Cancel Tassin, Geraldine" uniqKey="Cancel Tassin G" first="Geraldine" last="Cancel-Tassin">Geraldine Cancel-Tassin</name><affiliation><nlm:aff id="A59">Centre de Recherche sur les Pathologies Prostatiques, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A60">UPMC Univ Paris 06, GRC n°5, ONCOTYPE-URO, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Roupret, Morgan" sort="Roupret, Morgan" uniqKey="Roupret M" first="Morgan" last="Roupret">Morgan Roupret</name><affiliation><nlm:aff id="A59">Centre de Recherche sur les Pathologies Prostatiques, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A60">UPMC Univ Paris 06, GRC n°5, ONCOTYPE-URO, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A61">AP-HP, Hopital Pitie-Salpetriere, GHU-Est, Departments of Urology and Pathology, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Comperat, Eva" sort="Comperat, Eva" uniqKey="Comperat E" first="Eva" last="Comperat">Eva Comperat</name><affiliation><nlm:aff id="A59">Centre de Recherche sur les Pathologies Prostatiques, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A60">UPMC Univ Paris 06, GRC n°5, ONCOTYPE-URO, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A61">AP-HP, Hopital Pitie-Salpetriere, GHU-Est, Departments of Urology and Pathology, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Porru, Stefano" sort="Porru, Stefano" uniqKey="Porru S" first="Stefano" last="Porru">Stefano Porru</name><affiliation><nlm:aff id="A62">Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy</nlm:aff></affiliation></author><author><name sortKey="Carta, Angela" sort="Carta, Angela" uniqKey="Carta A" first="Angela" last="Carta">Angela Carta</name><affiliation><nlm:aff id="A62">Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy</nlm:aff></affiliation></author><author><name sortKey="Pavanello, Sofia" sort="Pavanello, Sofia" uniqKey="Pavanello S" first="Sofia" last="Pavanello">Sofia Pavanello</name><affiliation><nlm:aff id="A63">Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padua, Italy</nlm:aff></affiliation></author><author><name sortKey="Arici, Cecilia" sort="Arici, Cecilia" uniqKey="Arici C" first="Cecilia" last="Arici">Cecilia Arici</name><affiliation><nlm:aff id="A62">Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy</nlm:aff></affiliation></author><author><name sortKey="Mastrangelo, Giuseppe" sort="Mastrangelo, Giuseppe" uniqKey="Mastrangelo G" first="Giuseppe" last="Mastrangelo">Giuseppe Mastrangelo</name><affiliation><nlm:aff id="A63">Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padua, Italy</nlm:aff></affiliation></author><author><name sortKey="Grossman, H Barton" sort="Grossman, H Barton" uniqKey="Grossman H" first="H. Barton" last="Grossman">H. Barton Grossman</name><affiliation><nlm:aff id="A64">Department of Urology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA</nlm:aff></affiliation></author><author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name><affiliation><nlm:aff id="A65">Cancer Genomics Research Laboratory, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Deng, Xiang" sort="Deng, Xiang" uniqKey="Deng X" first="Xiang" last="Deng">Xiang Deng</name><affiliation><nlm:aff id="A65">Cancer Genomics Research Laboratory, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Chung, Charles C" sort="Chung, Charles C" uniqKey="Chung C" first="Charles C." last="Chung">Charles C. Chung</name><affiliation><nlm:aff id="A65">Cancer Genomics Research Laboratory, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Hutchinson, Amy" sort="Hutchinson, Amy" uniqKey="Hutchinson A" first="Amy" last="Hutchinson">Amy Hutchinson</name><affiliation><nlm:aff id="A65">Cancer Genomics Research Laboratory, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Burdette, Laurie" sort="Burdette, Laurie" uniqKey="Burdette L" first="Laurie" last="Burdette">Laurie Burdette</name><affiliation><nlm:aff id="A65">Cancer Genomics Research Laboratory, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Wheeler, William" sort="Wheeler, William" uniqKey="Wheeler W" first="William" last="Wheeler">William Wheeler</name><affiliation><nlm:aff id="A66">Information Management Services, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Fraumeni, Joseph" sort="Fraumeni, Joseph" uniqKey="Fraumeni J" first="Joseph" last="Fraumeni">Joseph Fraumeni</name><affiliation><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. 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Silverman</name><affiliation><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Rothman, Nathaniel" sort="Rothman, Nathaniel" uniqKey="Rothman N" first="Nathaniel" last="Rothman">Nathaniel Rothman</name><affiliation><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Prokunina Olsson, Ludmila" sort="Prokunina Olsson, Ludmila" uniqKey="Prokunina Olsson L" first="Ludmila" last="Prokunina-Olsson">Ludmila Prokunina-Olsson</name><affiliation><nlm:aff id="A1">Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25320178</idno><idno type="pmc">4203382</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203382</idno><idno type="RBID">PMC:4203382</idno><idno type="doi">10.1158/0008-5472.CAN-14-1531</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001F13</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001F13</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The 19q12 bladder cancer GWAS signal: association with cyclin E function and aggressive disease</title><author><name sortKey="Fu, Yi Ping" sort="Fu, Yi Ping" uniqKey="Fu Y" first="Yi-Ping" last="Fu">Yi-Ping Fu</name><affiliation><nlm:aff id="A1">Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Kohaar, Indu" sort="Kohaar, Indu" uniqKey="Kohaar I" first="Indu" last="Kohaar">Indu Kohaar</name><affiliation><nlm:aff id="A1">Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Moore, Lee E" sort="Moore, Lee E" uniqKey="Moore L" first="Lee E." last="Moore">Lee E. Moore</name><affiliation><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Lenz, Petra" sort="Lenz, Petra" uniqKey="Lenz P" first="Petra" last="Lenz">Petra Lenz</name><affiliation><nlm:aff id="A3">Clinical Research Directorate/Clinical Monitoring Research Program, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Figueroa, Jonine D" sort="Figueroa, Jonine D" uniqKey="Figueroa J" first="Jonine D." last="Figueroa">Jonine D. Figueroa</name><affiliation><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Tang, Wei" sort="Tang, Wei" uniqKey="Tang W" first="Wei" last="Tang">Wei Tang</name><affiliation><nlm:aff id="A1">Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Porter Gill, Patricia" sort="Porter Gill, Patricia" uniqKey="Porter Gill P" first="Patricia" last="Porter-Gill">Patricia Porter-Gill</name><affiliation><nlm:aff id="A1">Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Chatterjee, Nilanjan" sort="Chatterjee, Nilanjan" uniqKey="Chatterjee N" first="Nilanjan" last="Chatterjee">Nilanjan Chatterjee</name><affiliation><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Scott Johnson, Alexandra" sort="Scott Johnson, Alexandra" uniqKey="Scott Johnson A" first="Alexandra" last="Scott-Johnson">Alexandra Scott-Johnson</name><affiliation><nlm:aff id="A1">Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name><affiliation><nlm:aff id="A4">Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Muchmore, Brian" sort="Muchmore, Brian" uniqKey="Muchmore B" first="Brian" last="Muchmore">Brian Muchmore</name><affiliation><nlm:aff id="A1">Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Baris, Dalsu" sort="Baris, Dalsu" uniqKey="Baris D" first="Dalsu" last="Baris">Dalsu Baris</name><affiliation><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Paquin, Ashley" sort="Paquin, Ashley" uniqKey="Paquin A" first="Ashley" last="Paquin">Ashley Paquin</name><affiliation><nlm:aff id="A1">Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Ylaya, Kris" sort="Ylaya, Kris" uniqKey="Ylaya K" first="Kris" last="Ylaya">Kris Ylaya</name><affiliation><nlm:aff id="A5">Laboratory of Pathology, Center of Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Schwenn, Molly" sort="Schwenn, Molly" uniqKey="Schwenn M" first="Molly" last="Schwenn">Molly Schwenn</name><affiliation><nlm:aff id="A6">Maine Cancer Registry, Augusta, Maine, USA</nlm:aff></affiliation></author><author><name sortKey="Apolo, Andrea B" sort="Apolo, Andrea B" uniqKey="Apolo A" first="Andrea B." last="Apolo">Andrea B. Apolo</name><affiliation><nlm:aff id="A7">Genitourinary Malignancy Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Karagas, Margaret R" sort="Karagas, Margaret R" uniqKey="Karagas M" first="Margaret R." last="Karagas">Margaret R. Karagas</name><affiliation><nlm:aff id="A8">Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA</nlm:aff></affiliation></author><author><name sortKey="Tarway, Mcanthony" sort="Tarway, Mcanthony" uniqKey="Tarway M" first="Mcanthony" last="Tarway">Mcanthony Tarway</name><affiliation><nlm:aff id="A1">Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Johnson, Alison" sort="Johnson, Alison" uniqKey="Johnson A" first="Alison" last="Johnson">Alison Johnson</name><affiliation><nlm:aff id="A9">Vermont Cancer Registry, Burlington, Vermont, USA</nlm:aff></affiliation></author><author><name sortKey="Mumy, Adam" sort="Mumy, Adam" uniqKey="Mumy A" first="Adam" last="Mumy">Adam Mumy</name><affiliation><nlm:aff id="A1">Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Schned, Alan" sort="Schned, Alan" uniqKey="Schned A" first="Alan" last="Schned">Alan Schned</name><affiliation><nlm:aff id="A8">Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA</nlm:aff></affiliation></author><author><name sortKey="Guedez, Liliana" sort="Guedez, Liliana" uniqKey="Guedez L" first="Liliana" last="Guedez">Liliana Guedez</name><affiliation><nlm:aff id="A10">Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Jones, Michael A" sort="Jones, Michael A" uniqKey="Jones M" first="Michael A." last="Jones">Michael A. Jones</name><affiliation><nlm:aff id="A11">Department of Pathology and Laboratory Medicine, Maine Medical Center, Portland, Maine, USA</nlm:aff></affiliation></author><author><name sortKey="Kida, Masatoshi" sort="Kida, Masatoshi" uniqKey="Kida M" first="Masatoshi" last="Kida">Masatoshi Kida</name><affiliation><nlm:aff id="A12">Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont, USA</nlm:aff></affiliation></author><author><name sortKey="Monawar Hosain, Gm" sort="Monawar Hosain, Gm" uniqKey="Monawar Hosain G" first="Gm" last="Monawar Hosain">Gm Monawar Hosain</name><affiliation><nlm:aff id="A13">New Hampshire State Cancer Registry, Concord, New Hampshire, USA</nlm:aff></affiliation></author><author><name sortKey="Malats, Nuria" sort="Malats, Nuria" uniqKey="Malats N" first="Nuria" last="Malats">Nuria Malats</name><affiliation><nlm:aff id="A14">Spanish National Cancer Research Centre, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Kogevinas, Manolis" sort="Kogevinas, Manolis" uniqKey="Kogevinas M" first="Manolis" last="Kogevinas">Manolis Kogevinas</name><affiliation><nlm:aff id="A15">Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A17">National School of Public Health, Athens, Greece</nlm:aff></affiliation><affiliation><nlm:aff id="A18">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Tardon, Adonina" sort="Tardon, Adonina" uniqKey="Tardon A" first="Adonina" last="Tardon">Adonina Tardon</name><affiliation><nlm:aff id="A18">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A19">Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Spain</nlm:aff></affiliation></author><author><name sortKey="Serra, Consol" sort="Serra, Consol" uniqKey="Serra C" first="Consol" last="Serra">Consol Serra</name><affiliation><nlm:aff id="A18">CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A20">Universitat Pompeu Fabra, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Carrato, Alfredo" sort="Carrato, Alfredo" uniqKey="Carrato A" first="Alfredo" last="Carrato">Alfredo Carrato</name><affiliation><nlm:aff id="A21">Ramón y Cajal Hospital, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Reina" sort="Garcia Closas, Reina" uniqKey="Garcia Closas R" first="Reina" last="Garcia-Closas">Reina Garcia-Closas</name><affiliation><nlm:aff id="A22">Unidad de Investigación, Hospital Universitario de Canarias, La Laguna, Spain</nlm:aff></affiliation></author><author><name sortKey="Lloreta, Josep" sort="Lloreta, Josep" uniqKey="Lloreta J" first="Josep" last="Lloreta">Josep Lloreta</name><affiliation><nlm:aff id="A23">Hospital del Mar-IMIM, Univesitat Pompeu Fabra, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Wu, Xifeng" sort="Wu, Xifeng" uniqKey="Wu X" first="Xifeng" last="Wu">Xifeng Wu</name><affiliation><nlm:aff id="A24">Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA</nlm:aff></affiliation></author><author><name sortKey="Purdue, Mark" sort="Purdue, Mark" uniqKey="Purdue M" first="Mark" last="Purdue">Mark Purdue</name><affiliation><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Andriole, Gerald L" sort="Andriole, Gerald L" uniqKey="Andriole G" first="Gerald L." last="Andriole">Gerald L. Andriole</name><affiliation><nlm:aff id="A25">Division of Urologic Surgery, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff></affiliation></author><author><name sortKey="Grubb, Robert L" sort="Grubb, Robert L" uniqKey="Grubb R" first="Robert L." last="Grubb">Robert L. Grubb</name><affiliation><nlm:aff id="A25">Division of Urologic Surgery, Washington University School of Medicine, St. Louis, Missouri, USA</nlm:aff></affiliation></author><author><name sortKey="Black, Amanda" sort="Black, Amanda" uniqKey="Black A" first="Amanda" last="Black">Amanda Black</name><affiliation><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Landi, Maria T" sort="Landi, Maria T" uniqKey="Landi M" first="Maria T." last="Landi">Maria T. Landi</name><affiliation><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Caporaso, Neil E" sort="Caporaso, Neil E" uniqKey="Caporaso N" first="Neil E." last="Caporaso">Neil E. Caporaso</name><affiliation><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name><affiliation><nlm:aff id="A26">School of Public Health, Imperial College London, London, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Human Genetics Foundation (HuGeF), Torino, Italy</nlm:aff></affiliation></author><author><name sortKey="Siddiq, Afshan" sort="Siddiq, Afshan" uniqKey="Siddiq A" first="Afshan" last="Siddiq">Afshan Siddiq</name><affiliation><nlm:aff id="A26">School of Public Health, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H. Bas" last="Bueno-De-Mesquita">H. Bas Bueno-De-Mesquita</name><affiliation><nlm:aff id="A29">National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A67">Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, United Kingdom</nlm:aff></affiliation><affiliation><nlm:aff id="A68">Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia</nlm:aff></affiliation></author><author><name sortKey="Trichopoulos, Dimitrios" sort="Trichopoulos, Dimitrios" uniqKey="Trichopoulos D" first="Dimitrios" last="Trichopoulos">Dimitrios Trichopoulos</name><affiliation><nlm:aff id="A31">Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A32">Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Hellenic Health Foundation, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Ljungberg, Borje" sort="Ljungberg, Borje" uniqKey="Ljungberg B" first="Börje" last="Ljungberg">Börje Ljungberg</name><affiliation><nlm:aff id="A34">Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden</nlm:aff></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:aff id="A27">Human Genetics Foundation (HuGeF), Torino, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A35">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A36">Centre for Epidemiology and Biostatistics, University of Melbourne, Australia</nlm:aff></affiliation></author><author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name><affiliation><nlm:aff id="A37">Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A38">Department of Research, Cancer Registry of Norway, Oslo, Norway</nlm:aff></affiliation><affiliation><nlm:aff id="A39">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation><affiliation><nlm:aff id="A40">Samfundet Folkhälsan, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Krogh, Vittorio" sort="Krogh, Vittorio" uniqKey="Krogh V" first="Vittorio" last="Krogh">Vittorio Krogh</name><affiliation><nlm:aff id="A41">Fondazione IRCCS Istituto Nazionale dei Tumori - Milano, Italy</nlm:aff></affiliation></author><author><name sortKey="Dorronsoro, Miren" sort="Dorronsoro, Miren" uniqKey="Dorronsoro M" first="Miren" last="Dorronsoro">Miren Dorronsoro</name><affiliation><nlm:aff id="A42">Public Health Division of Gipuzkoa, Basque Regional Health Department and Ciberesp-Biodonostia, San Sebastian, Spain</nlm:aff></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name><affiliation><nlm:aff id="A43">Cancer Epidemiology Unit, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Tj Nneland, Anne" sort="Tj Nneland, Anne" uniqKey="Tj Nneland A" first="Anne" last="Tj Nneland">Anne Tj Nneland</name><affiliation><nlm:aff id="A44">Danish Cancer Society Research Center, Copenhagen, Denmark</nlm:aff></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation><nlm:aff id="A45">International Agency for Research on Cancer, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="A46">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><affiliation><nlm:aff id="A26">School of Public Health, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Prescott, Jennifer" sort="Prescott, Jennifer" uniqKey="Prescott J" first="Jennifer" last="Prescott">Jennifer Prescott</name><affiliation><nlm:aff id="A47">Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Chen, Constance" sort="Chen, Constance" uniqKey="Chen C" first="Constance" last="Chen">Constance Chen</name><affiliation><nlm:aff id="A48">Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="De Vivo, Immaculata" sort="De Vivo, Immaculata" uniqKey="De Vivo I" first="Immaculata" last="De Vivo">Immaculata De Vivo</name><affiliation><nlm:aff id="A47">Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Govannucci, Edward" sort="Govannucci, Edward" uniqKey="Govannucci E" first="Edward" last="Govannucci">Edward Govannucci</name><affiliation><nlm:aff id="A49">Department of Nutrition and Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Hunter, David" sort="Hunter, David" uniqKey="Hunter D" first="David" last="Hunter">David Hunter</name><affiliation><nlm:aff id="A48">Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:aff id="A48">Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindstrom">Sara Lindstrom</name><affiliation><nlm:aff id="A48">Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</nlm:aff></affiliation></author><author><name sortKey="Gapstur, Susan M" sort="Gapstur, Susan M" uniqKey="Gapstur S" first="Susan M." last="Gapstur">Susan M. Gapstur</name><affiliation><nlm:aff id="A50">Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</nlm:aff></affiliation></author><author><name sortKey="Jacobs, Eric J" sort="Jacobs, Eric J" uniqKey="Jacobs E" first="Eric J." last="Jacobs">Eric J. Jacobs</name><affiliation><nlm:aff id="A50">Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</nlm:aff></affiliation></author><author><name sortKey="Diver, W Ryan" sort="Diver, W Ryan" uniqKey="Diver W" first="W. Ryan" last="Diver">W. Ryan Diver</name><affiliation><nlm:aff id="A50">Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</nlm:aff></affiliation></author><author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name><affiliation><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Weinstein, Stephanie J" sort="Weinstein, Stephanie J" uniqKey="Weinstein S" first="Stephanie J." last="Weinstein">Stephanie J. Weinstein</name><affiliation><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name><affiliation><nlm:aff id="A51">National Institute for Health and Welfare, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Kooperberg, Charles" sort="Kooperberg, Charles" uniqKey="Kooperberg C" first="Charles" last="Kooperberg">Charles Kooperberg</name><affiliation><nlm:aff id="A52">Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Hohensee, Chancellor" sort="Hohensee, Chancellor" uniqKey="Hohensee C" first="Chancellor" last="Hohensee">Chancellor Hohensee</name><affiliation><nlm:aff id="A52">Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Rodabough, Rebecca J" sort="Rodabough, Rebecca J" uniqKey="Rodabough R" first="Rebecca J." last="Rodabough">Rebecca J. Rodabough</name><affiliation><nlm:aff id="A52">Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Cortessis, Victoria K" sort="Cortessis, Victoria K" uniqKey="Cortessis V" first="Victoria K." last="Cortessis">Victoria K. Cortessis</name><affiliation><nlm:aff id="A53">Department of Obstetrics & Gynecology, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A54">Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Conti, David V" sort="Conti, David V" uniqKey="Conti D" first="David V." last="Conti">David V. Conti</name><affiliation><nlm:aff id="A54">Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Gago Dominguez, Manuela" sort="Gago Dominguez, Manuela" uniqKey="Gago Dominguez M" first="Manuela" last="Gago-Dominguez">Manuela Gago-Dominguez</name><affiliation><nlm:aff id="A55">Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain</nlm:aff></affiliation></author><author><name sortKey="Stern, Mariana C" sort="Stern, Mariana C" uniqKey="Stern M" first="Mariana C." last="Stern">Mariana C. Stern</name><affiliation><nlm:aff id="A54">Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Pike, Malcolm C" sort="Pike, Malcolm C" uniqKey="Pike M" first="Malcolm C." last="Pike">Malcolm C. Pike</name><affiliation><nlm:aff id="A56">Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA</nlm:aff></affiliation></author><author><name sortKey="Van Den Berg, David" sort="Van Den Berg, David" uniqKey="Van Den Berg D" first="David" last="Van Den Berg">David Van Den Berg</name><affiliation><nlm:aff id="A54">Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Yuan, Jian Min" sort="Yuan, Jian Min" uniqKey="Yuan J" first="Jian-Min" last="Yuan">Jian-Min Yuan</name><affiliation><nlm:aff id="A57">University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA</nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff id="A54">Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Cussenot, Olivier" sort="Cussenot, Olivier" uniqKey="Cussenot O" first="Olivier" last="Cussenot">Olivier Cussenot</name><affiliation><nlm:aff id="A58">AP-HP, Hopital Tenon, GHU-Est, Department of Urology, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A59">Centre de Recherche sur les Pathologies Prostatiques, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A60">UPMC Univ Paris 06, GRC n°5, ONCOTYPE-URO, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Cancel Tassin, Geraldine" sort="Cancel Tassin, Geraldine" uniqKey="Cancel Tassin G" first="Geraldine" last="Cancel-Tassin">Geraldine Cancel-Tassin</name><affiliation><nlm:aff id="A59">Centre de Recherche sur les Pathologies Prostatiques, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A60">UPMC Univ Paris 06, GRC n°5, ONCOTYPE-URO, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Roupret, Morgan" sort="Roupret, Morgan" uniqKey="Roupret M" first="Morgan" last="Roupret">Morgan Roupret</name><affiliation><nlm:aff id="A59">Centre de Recherche sur les Pathologies Prostatiques, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A60">UPMC Univ Paris 06, GRC n°5, ONCOTYPE-URO, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A61">AP-HP, Hopital Pitie-Salpetriere, GHU-Est, Departments of Urology and Pathology, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Comperat, Eva" sort="Comperat, Eva" uniqKey="Comperat E" first="Eva" last="Comperat">Eva Comperat</name><affiliation><nlm:aff id="A59">Centre de Recherche sur les Pathologies Prostatiques, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A60">UPMC Univ Paris 06, GRC n°5, ONCOTYPE-URO, Paris, France</nlm:aff></affiliation><affiliation><nlm:aff id="A61">AP-HP, Hopital Pitie-Salpetriere, GHU-Est, Departments of Urology and Pathology, Paris, France</nlm:aff></affiliation></author><author><name sortKey="Porru, Stefano" sort="Porru, Stefano" uniqKey="Porru S" first="Stefano" last="Porru">Stefano Porru</name><affiliation><nlm:aff id="A62">Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy</nlm:aff></affiliation></author><author><name sortKey="Carta, Angela" sort="Carta, Angela" uniqKey="Carta A" first="Angela" last="Carta">Angela Carta</name><affiliation><nlm:aff id="A62">Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy</nlm:aff></affiliation></author><author><name sortKey="Pavanello, Sofia" sort="Pavanello, Sofia" uniqKey="Pavanello S" first="Sofia" last="Pavanello">Sofia Pavanello</name><affiliation><nlm:aff id="A63">Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padua, Italy</nlm:aff></affiliation></author><author><name sortKey="Arici, Cecilia" sort="Arici, Cecilia" uniqKey="Arici C" first="Cecilia" last="Arici">Cecilia Arici</name><affiliation><nlm:aff id="A62">Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy</nlm:aff></affiliation></author><author><name sortKey="Mastrangelo, Giuseppe" sort="Mastrangelo, Giuseppe" uniqKey="Mastrangelo G" first="Giuseppe" last="Mastrangelo">Giuseppe Mastrangelo</name><affiliation><nlm:aff id="A63">Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padua, Italy</nlm:aff></affiliation></author><author><name sortKey="Grossman, H Barton" sort="Grossman, H Barton" uniqKey="Grossman H" first="H. Barton" last="Grossman">H. Barton Grossman</name><affiliation><nlm:aff id="A64">Department of Urology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA</nlm:aff></affiliation></author><author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name><affiliation><nlm:aff id="A65">Cancer Genomics Research Laboratory, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Deng, Xiang" sort="Deng, Xiang" uniqKey="Deng X" first="Xiang" last="Deng">Xiang Deng</name><affiliation><nlm:aff id="A65">Cancer Genomics Research Laboratory, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Chung, Charles C" sort="Chung, Charles C" uniqKey="Chung C" first="Charles C." last="Chung">Charles C. Chung</name><affiliation><nlm:aff id="A65">Cancer Genomics Research Laboratory, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Hutchinson, Amy" sort="Hutchinson, Amy" uniqKey="Hutchinson A" first="Amy" last="Hutchinson">Amy Hutchinson</name><affiliation><nlm:aff id="A65">Cancer Genomics Research Laboratory, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Burdette, Laurie" sort="Burdette, Laurie" uniqKey="Burdette L" first="Laurie" last="Burdette">Laurie Burdette</name><affiliation><nlm:aff id="A65">Cancer Genomics Research Laboratory, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Wheeler, William" sort="Wheeler, William" uniqKey="Wheeler W" first="William" last="Wheeler">William Wheeler</name><affiliation><nlm:aff id="A66">Information Management Services, Rockville, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Fraumeni, Joseph" sort="Fraumeni, Joseph" uniqKey="Fraumeni J" first="Joseph" last="Fraumeni">Joseph Fraumeni</name><affiliation><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Hewitt, Stephen M" sort="Hewitt, Stephen M" uniqKey="Hewitt S" first="Stephen M." last="Hewitt">Stephen M. Hewitt</name><affiliation><nlm:aff id="A5">Laboratory of Pathology, Center of Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Silverman, Debra T" sort="Silverman, Debra T" uniqKey="Silverman D" first="Debra T." last="Silverman">Debra T. Silverman</name><affiliation><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Rothman, Nathaniel" sort="Rothman, Nathaniel" uniqKey="Rothman N" first="Nathaniel" last="Rothman">Nathaniel Rothman</name><affiliation><nlm:aff id="A2">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Prokunina Olsson, Ludmila" sort="Prokunina Olsson, Ludmila" uniqKey="Prokunina Olsson L" first="Ludmila" last="Prokunina-Olsson">Ludmila Prokunina-Olsson</name><affiliation><nlm:aff id="A1">Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Cancer research</title><idno type="ISSN">0008-5472</idno><idno type="eISSN">1538-7445</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">A genome-wide association study (GWAS) of bladder cancer identified a genetic marker rs8102137 within the 19q12 region as a novel susceptibility variant. This marker is located upstream of the <italic>CCNE1</italic> gene, which encodes cyclin E, a cell cycle protein. We performed genetic fine mapping analysis of the <italic>CCNE1</italic> region using data from two bladder cancer GWAS (5,942 cases and 10,857 controls). We found that the original GWAS marker rs8102137 represents a group of 47 linked SNPs (with r<sup>2</sup>≥0.7) associated with increased bladder cancer risk. From this group we selected a functional promoter variant rs7257330, which showed strong allele-specific binding of nuclear proteins in several cell lines. In both GWAS, rs7257330 was associated only with aggressive bladder cancer, with a combined per-allele odds ratio (OR) =1.18 (95%CI=1.09-1.27, p=4.67×10<sup>−5</sup> vs. OR =1.01 (95%CI=0.93-1.10, p=0.79) for non-aggressive disease, with p=0.0015 for case-only analysis. Cyclin E protein expression analyzed in 265 bladder tumors was increased in aggressive tumors (p=0.013) and, independently, with each rs7257330-A risk allele (p<sub>trend</sub>=0.024). Over-expression of recombinant cyclin E in cell lines caused significant acceleration of cell cycle. In conclusion, we defined the 19q12 signal as the first GWAS signal specific for aggressive bladder cancer. Molecular mechanisms of this genetic association may be related to cyclin E over-expression and alteration of cell cycle in carriers of <italic>CCNE1</italic> risk variants. In combination with established bladder cancer risk factors and other somatic and germline genetic markers, the <italic>CCNE1</italic> variants could be useful for inclusion into bladder cancer risk prediction models.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">2984705R</journal-id><journal-id journal-id-type="pubmed-jr-id">2786</journal-id><journal-id journal-id-type="nlm-ta">Cancer Res</journal-id><journal-id journal-id-type="iso-abbrev">Cancer Res.</journal-id><journal-title-group><journal-title>Cancer research</journal-title></journal-title-group><issn pub-type="ppub">0008-5472</issn><issn pub-type="epub">1538-7445</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25320178</article-id><article-id pub-id-type="pmc">4203382</article-id><article-id pub-id-type="doi">10.1158/0008-5472.CAN-14-1531</article-id><article-id pub-id-type="manuscript">NIHMS624217</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>The 19q12 bladder cancer GWAS signal: association with cyclin E function and aggressive disease</article-title></title-group><contrib-group><contrib 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id="A1"><label>1</label>Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</aff><aff id="A2"><label>2</label>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</aff><aff id="A3"><label>3</label>Clinical Research Directorate/Clinical Monitoring Research Program, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA</aff><aff id="A4"><label>4</label>Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK</aff><aff id="A5"><label>5</label>Laboratory of Pathology, Center of Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</aff><aff id="A6"><label>6</label>Maine Cancer Registry, Augusta, Maine, USA</aff><aff id="A7"><label>7</label>Genitourinary Malignancy Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA</aff><aff id="A8"><label>8</label>Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA</aff><aff id="A9"><label>9</label>Vermont Cancer Registry, Burlington, Vermont, USA</aff><aff id="A10"><label>10</label>Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA</aff><aff id="A11"><label>11</label>Department of Pathology and Laboratory Medicine, Maine Medical Center, Portland, Maine, USA</aff><aff id="A12"><label>12</label>Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont, USA</aff><aff id="A13"><label>13</label>New Hampshire State Cancer Registry, Concord, New Hampshire, USA</aff><aff id="A14"><label>14</label>Spanish National Cancer Research Centre, Madrid, Spain</aff><aff id="A15"><label>15</label>Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain</aff><aff id="A16"><label>16</label>Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain</aff><aff id="A17"><label>17</label>National School of Public Health, Athens, Greece</aff><aff id="A18"><label>18</label>CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Spain</aff><aff id="A19"><label>19</label>Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Spain</aff><aff id="A20"><label>20</label>Universitat Pompeu Fabra, Barcelona, Spain</aff><aff id="A21"><label>21</label>Ramón y Cajal Hospital, Madrid, Spain</aff><aff id="A22"><label>22</label>Unidad de Investigación, Hospital Universitario de Canarias, La Laguna, Spain</aff><aff id="A23"><label>23</label>Hospital del Mar-IMIM, Univesitat Pompeu Fabra, Barcelona, Spain</aff><aff id="A24"><label>24</label>Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA</aff><aff id="A25"><label>25</label>Division of Urologic Surgery, Washington University School of Medicine, St. Louis, Missouri, USA</aff><aff id="A26"><label>26</label>School of Public Health, Imperial College London, London, UK</aff><aff id="A27"><label>27</label>Human Genetics Foundation (HuGeF), Torino, Italy</aff><aff id="A28"><label>28</label>Department of Genetics, Biology and Biochemistry, University of Torino, Torino, Italy</aff><aff id="A29"><label>29</label>National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands</aff><aff id="A30"><label>30</label>Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands</aff><aff id="A31"><label>31</label>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</aff><aff id="A32"><label>32</label>Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece</aff><aff id="A33"><label>33</label>Hellenic Health Foundation, Athens, Greece</aff><aff id="A34"><label>34</label>Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden</aff><aff id="A35"><label>35</label>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</aff><aff id="A36"><label>36</label>Centre for Epidemiology and Biostatistics, University of Melbourne, Australia</aff><aff id="A37"><label>37</label>Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway</aff><aff id="A38"><label>38</label>Department of Research, Cancer Registry of Norway, Oslo, Norway</aff><aff id="A39"><label>39</label>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</aff><aff id="A40"><label>40</label>Samfundet Folkhälsan, Helsinki, Finland</aff><aff id="A41"><label>41</label>Fondazione IRCCS Istituto Nazionale dei Tumori - Milano, Italy</aff><aff id="A42"><label>42</label>Public Health Division of Gipuzkoa, Basque Regional Health Department and Ciberesp-Biodonostia, San Sebastian, Spain</aff><aff id="A43"><label>43</label>Cancer Epidemiology Unit, University of Oxford, Oxford, UK</aff><aff id="A44"><label>44</label>Danish Cancer Society Research Center, Copenhagen, Denmark</aff><aff id="A45"><label>45</label>International Agency for Research on Cancer, Lyon, France</aff><aff id="A46"><label>46</label>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="A47"><label>47</label>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA</aff><aff id="A48"><label>48</label>Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</aff><aff id="A49"><label>49</label>Department of Nutrition and Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA</aff><aff id="A50"><label>50</label>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA</aff><aff id="A51"><label>51</label>National Institute for Health and Welfare, Helsinki, Finland</aff><aff id="A52"><label>52</label>Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington, USA</aff><aff id="A53"><label>53</label>Department of Obstetrics & Gynecology, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA</aff><aff id="A54"><label>54</label>Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA</aff><aff id="A55"><label>55</label>Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain</aff><aff id="A56"><label>56</label>Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA</aff><aff id="A57"><label>57</label>University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA</aff><aff id="A58"><label>58</label>AP-HP, Hopital Tenon, GHU-Est, Department of Urology, Paris, France</aff><aff id="A59"><label>59</label>Centre de Recherche sur les Pathologies Prostatiques, Paris, France</aff><aff id="A60"><label>60</label>UPMC Univ Paris 06, GRC n°5, ONCOTYPE-URO, Paris, France</aff><aff id="A61"><label>61</label>AP-HP, Hopital Pitie-Salpetriere, GHU-Est, Departments of Urology and Pathology, Paris, France</aff><aff id="A62"><label>62</label>Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy</aff><aff id="A63"><label>63</label>Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padua, Italy</aff><aff id="A64"><label>64</label>Department of Urology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA</aff><aff id="A65"><label>65</label>Cancer Genomics Research Laboratory, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA</aff><aff id="A66"><label>66</label>Information Management Services, Rockville, MD, USA</aff><aff id="A67"><label>67</label>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, United Kingdom</aff><aff id="A68"><label>68</label>Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia</aff><author-notes><corresp id="FN1">Corresponding Author: Ludmila Prokunina-Olsson, PhD, Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 8717 Grovemont Circle, Bethesda, 20892-4605, MD, USA, Tel: 301-443-5297, Fax: 301-402-3134, <email>prokuninal@mail.nih.gov</email></corresp><fn id="FN2" fn-type="equal"><label>*</label><p>Authors contributed equally.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>11</day><month>9</month><year>2014</year></pub-date><pub-date pub-type="ppub"><day>15</day><month>10</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>15</day><month>4</month><year>2015</year></pub-date><volume>74</volume><issue>20</issue><fpage>5808</fpage><lpage>5818</lpage><pmc-comment>elocation-id from pubmed: 10.1158/0008-5472.CAN-14-1531</pmc-comment>
<abstract><p id="P1">A genome-wide association study (GWAS) of bladder cancer identified a genetic marker rs8102137 within the 19q12 region as a novel susceptibility variant. This marker is located upstream of the <italic>CCNE1</italic> gene, which encodes cyclin E, a cell cycle protein. We performed genetic fine mapping analysis of the <italic>CCNE1</italic> region using data from two bladder cancer GWAS (5,942 cases and 10,857 controls). We found that the original GWAS marker rs8102137 represents a group of 47 linked SNPs (with r<sup>2</sup>≥0.7) associated with increased bladder cancer risk. From this group we selected a functional promoter variant rs7257330, which showed strong allele-specific binding of nuclear proteins in several cell lines. In both GWAS, rs7257330 was associated only with aggressive bladder cancer, with a combined per-allele odds ratio (OR) =1.18 (95%CI=1.09-1.27, p=4.67×10<sup>−5</sup> vs. OR =1.01 (95%CI=0.93-1.10, p=0.79) for non-aggressive disease, with p=0.0015 for case-only analysis. Cyclin E protein expression analyzed in 265 bladder tumors was increased in aggressive tumors (p=0.013) and, independently, with each rs7257330-A risk allele (p<sub>trend</sub>=0.024). Over-expression of recombinant cyclin E in cell lines caused significant acceleration of cell cycle. In conclusion, we defined the 19q12 signal as the first GWAS signal specific for aggressive bladder cancer. Molecular mechanisms of this genetic association may be related to cyclin E over-expression and alteration of cell cycle in carriers of <italic>CCNE1</italic> risk variants. In combination with established bladder cancer risk factors and other somatic and germline genetic markers, the <italic>CCNE1</italic> variants could be useful for inclusion into bladder cancer risk prediction models.</p></abstract><kwd-group><kwd>Aggressive bladder cancer</kwd><kwd>cyclin E</kwd><kwd>cell cycle</kwd><kwd>single nucleotide polymorphism</kwd><kwd>GWAS</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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