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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A meta-analysis of individual participant data reveals an association between circulating levels of IGF-I and prostate cancer risk</title><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name><affiliation><nlm:aff id="A1">Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Appleby, Paul N" sort="Appleby, Paul N" uniqKey="Appleby P" first="Paul N." last="Appleby">Paul N. Appleby</name><affiliation><nlm:aff id="A1">Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Martin, Richard M" sort="Martin, Richard M" uniqKey="Martin R" first="Richard M." last="Martin">Richard M. Martin</name><affiliation><nlm:aff id="A2">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Medical Research Council/University of Bristol Integrative Epidemiology Unit, University of Bristol, and National Institute for Health Research, Bristol Biomedical Research Unit in Nutrition, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Holly, Jeff M P" sort="Holly, Jeff M P" uniqKey="Holly J" first="Jeff M. P." last="Holly">Jeff M. P. Holly</name><affiliation><nlm:aff id="A4">School of Clinical Science, Faculty of Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name><affiliation><nlm:aff id="A5">Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Black, Amanda" sort="Black, Amanda" uniqKey="Black A" first="Amanda" last="Black">Amanda Black</name><affiliation><nlm:aff id="A5">Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Bueno De Mesquita, H B As" sort="Bueno De Mesquita, H B As" uniqKey="Bueno De Mesquita H" first="H. B As" last="Bueno-De-Mesquita">H. B As Bueno-De-Mesquita</name><affiliation><nlm:aff id="A6">Dt. for Determinants of Chronic Diseases, National Institute for Public Health and the Environment (RIVM), Bilthoven, and Dt. of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands, and Dt. of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Chan, June M" sort="Chan, June M" uniqKey="Chan J" first="June M." last="Chan">June M. Chan</name><affiliation><nlm:aff id="A8">Departments of Epidemiology & Biostatistics and Urology, University of California San Francisco, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Chen, Chu" sort="Chen, Chu" uniqKey="Chen C" first="Chu" last="Chen">Chu Chen</name><affiliation><nlm:aff id="A9">Division of Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Chirlaque, Maria Dolores" sort="Chirlaque, Maria Dolores" uniqKey="Chirlaque M" first="Maria-Dolores" last="Chirlaque">Maria-Dolores Chirlaque</name><affiliation><nlm:aff id="A10">Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, and CIBER Epidemiología y Salud Pública, Spain</nlm:aff></affiliation></author><author><name sortKey="Cook, Michael B" sort="Cook, Michael B" uniqKey="Cook M" first="Michael B." last="Cook">Michael B. Cook</name><affiliation><nlm:aff id="A5">Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Deschasaux, Melanie" sort="Deschasaux, Melanie" uniqKey="Deschasaux M" first="Mélanie" last="Deschasaux">Mélanie Deschasaux</name><affiliation><nlm:aff id="A11">Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny, France</nlm:aff></affiliation></author><author><name sortKey="Donovan, Jenny L" sort="Donovan, Jenny L" uniqKey="Donovan J" first="Jenny L." last="Donovan">Jenny L. Donovan</name><affiliation><nlm:aff id="A2">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><affiliation><nlm:aff id="A12">Intramural Research Program, National Institute on Aging, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Galan, Pilar" sort="Galan, Pilar" uniqKey="Galan P" first="Pilar" last="Galan">Pilar Galan</name><affiliation><nlm:aff id="A11">Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny, France</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="A13">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, and Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L." last="Giovannucci">Edward L. Giovannucci</name><affiliation><nlm:aff id="A14">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A15">Department of Nutrition and Department of Medicine, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J." last="Gunter">Marc J. Gunter</name><affiliation><nlm:aff id="A7">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Habel, Laurel A" sort="Habel, Laurel A" uniqKey="Habel L" first="Laurel A." last="Habel">Laurel A. Habel</name><affiliation><nlm:aff id="A16">Division of Research, Kaiser Permanente, Northern California, Oakland, California, USA</nlm:aff></affiliation></author><author><name sortKey="Hamdy, Freddie C" sort="Hamdy, Freddie C" uniqKey="Hamdy F" first="Freddie C." last="Hamdy">Freddie C. Hamdy</name><affiliation><nlm:aff id="A17">Nuffield Department of Surgery, University of Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Helzlsouer, Kathy J" sort="Helzlsouer, Kathy J" uniqKey="Helzlsouer K" first="Kathy J." last="Helzlsouer">Kathy J. Helzlsouer</name><affiliation><nlm:aff id="A18">The Prevention and Research Center, Mercy Medical Center, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Hercberg, Serge" sort="Hercberg, Serge" uniqKey="Hercberg S" first="Serge" last="Hercberg">Serge Hercberg</name><affiliation><nlm:aff id="A11">Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny, France</nlm:aff></affiliation></author><author><name sortKey="Hoover, Robert N" sort="Hoover, Robert N" uniqKey="Hoover R" first="Robert N." last="Hoover">Robert N. Hoover</name><affiliation><nlm:aff id="A5">Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Janssen, Joseph A M J L" sort="Janssen, Joseph A M J L" uniqKey="Janssen J" first="Joseph A. M. J. L." last="Janssen">Joseph A. M. J. L. Janssen</name><affiliation><nlm:aff id="A19">Erasmus MC, Dept Internal Medicine, Rotterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation><nlm:aff id="A20">Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Kubo, Tatsuhiko" sort="Kubo, Tatsuhiko" uniqKey="Kubo T" first="Tatsuhiko" last="Kubo">Tatsuhiko Kubo</name><affiliation><nlm:aff id="A21">University of Occupational and Environmental Health, Kitakyushu, Japan</nlm:aff></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="A22">University of Hawaii Cancer Center, Honolulu, HI, USA</nlm:aff></affiliation></author><author><name sortKey="Metter, E Jeffrey" sort="Metter, E Jeffrey" uniqKey="Metter E" first="E. Jeffrey" last="Metter">E. Jeffrey Metter</name><affiliation><nlm:aff id="A12">Intramural Research Program, National Institute on Aging, Baltimore, MD, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Department of Neurology, University of Tennessee Health Science Center, Memphis, TN</nlm:aff></affiliation></author><author><name sortKey="Mikami, Kazuya" sort="Mikami, Kazuya" uniqKey="Mikami K" first="Kazuya" last="Mikami">Kazuya Mikami</name><affiliation><nlm:aff id="A24">Kyoto Prefectural University of Medicine, Kyoto, Japan</nlm:aff></affiliation></author><author><name sortKey="Morris, Joan K" sort="Morris, Joan K" uniqKey="Morris J" first="Joan K." last="Morris">Joan K. Morris</name><affiliation><nlm:aff id="A25">Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London, UK</nlm:aff></affiliation></author><author><name sortKey="Neal, David E" sort="Neal, David E" uniqKey="Neal D" first="David E." last="Neal">David E. Neal</name><affiliation><nlm:aff id="A26">Department of Oncology, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Neuhouser, Marian L" sort="Neuhouser, Marian L" uniqKey="Neuhouser M" first="Marian L." last="Neuhouser">Marian L. Neuhouser</name><affiliation><nlm:aff id="A9">Division of Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Ozasa, Kotaro" sort="Ozasa, Kotaro" uniqKey="Ozasa K" first="Kotaro" last="Ozasa">Kotaro Ozasa</name><affiliation><nlm:aff id="A27">Radiation Effects Research Foundation, Hiroshima, Japan</nlm:aff></affiliation></author><author><name sortKey="Palli, Domenico" sort="Palli, Domenico" uniqKey="Palli D" first="Domenico" last="Palli">Domenico Palli</name><affiliation><nlm:aff id="A28">Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Platz, Elizabeth A" sort="Platz, Elizabeth A" uniqKey="Platz E" first="Elizabeth A." last="Platz">Elizabeth A. Platz</name><affiliation><nlm:aff id="A29">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Pollak, Michael" sort="Pollak, Michael" uniqKey="Pollak M" first="Michael" last="Pollak">Michael Pollak</name><affiliation><nlm:aff id="A30">Departments of Medicine and Oncology, McGill University, Montreal, QC, Canada</nlm:aff></affiliation></author><author><name sortKey="Price, Alison J" sort="Price, Alison J" uniqKey="Price A" first="Alison J." last="Price">Alison J. Price</name><affiliation><nlm:aff id="A1">Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Roobol, Monique J" sort="Roobol, Monique J" uniqKey="Roobol M" first="Monique J." last="Roobol">Monique J. Roobol</name><affiliation><nlm:aff id="A31">Erasmus MC, Dept of Urology Rotterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Schaefer, Catherine" sort="Schaefer, Catherine" uniqKey="Schaefer C" first="Catherine" last="Schaefer">Catherine Schaefer</name><affiliation><nlm:aff id="A16">Division of Research, Kaiser Permanente, Northern California, Oakland, California, USA</nlm:aff></affiliation></author><author><name sortKey="Schenk, Jeannette M" sort="Schenk, Jeannette M" uniqKey="Schenk J" first="Jeannette M." last="Schenk">Jeannette M. Schenk</name><affiliation><nlm:aff id="A32">Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Department of Epidemiology, University of Washington, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:aff id="A13">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, and Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A34">Human Genetics Foundation, Torino, Italy</nlm:aff></affiliation></author><author><name sortKey="Stampfer, Meir J" sort="Stampfer, Meir J" uniqKey="Stampfer M" first="Meir J." last="Stampfer">Meir J. Stampfer</name><affiliation><nlm:aff id="A14">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A35">Channing Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Stattin, P R" sort="Stattin, P R" uniqKey="Stattin P" first="P R" last="Stattin">P R Stattin</name><affiliation><nlm:aff id="A36">Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden</nlm:aff></affiliation></author><author><name sortKey="Tamakoshi, Akiko" sort="Tamakoshi, Akiko" uniqKey="Tamakoshi A" first="Akiko" last="Tamakoshi">Akiko Tamakoshi</name><affiliation><nlm:aff id="A37">Hokkaido University Graduate School of Medicine, Sapporo, Japan</nlm:aff></affiliation></author><author><name sortKey="Tangen, Catherine M" sort="Tangen, Catherine M" uniqKey="Tangen C" first="Catherine M." last="Tangen">Catherine M. Tangen</name><affiliation><nlm:aff id="A38">SWOG Statistical Center, Fred Hutchinson Cancer Research Center, and Department of Biostatistics, University of Washington, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Touvier, Mathilde" sort="Touvier, Mathilde" uniqKey="Touvier M" first="Mathilde" last="Touvier">Mathilde Touvier</name><affiliation><nlm:aff id="A11">Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny, France</nlm:aff></affiliation></author><author><name sortKey="Wald, Nicholas J" sort="Wald, Nicholas J" uniqKey="Wald N" first="Nicholas J." last="Wald">Nicholas J. Wald</name><affiliation><nlm:aff id="A26">Department of Oncology, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Weiss, Noel S" sort="Weiss, Noel S" uniqKey="Weiss N" first="Noel S." last="Weiss">Noel S. Weiss</name><affiliation><nlm:aff id="A34">Human Genetics Foundation, Torino, Italy</nlm:aff></affiliation></author><author><name sortKey="Ziegler, Regina G" sort="Ziegler, Regina G" uniqKey="Ziegler R" first="Regina G." last="Ziegler">Regina G. Ziegler</name><affiliation><nlm:aff id="A5">Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Key, Timothy J" sort="Key, Timothy J" uniqKey="Key T" first="Timothy J." last="Key">Timothy J. Key</name><affiliation><nlm:aff id="A1">Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Allen, Naomi E" sort="Allen, Naomi E" uniqKey="Allen N" first="Naomi E." last="Allen">Naomi E. Allen</name><affiliation><nlm:aff id="A39">Clinical Trials Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26921328</idno><idno type="pmc">4873385</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873385</idno><idno type="RBID">PMC:4873385</idno><idno type="doi">10.1158/0008-5472.CAN-15-1551</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">001F14</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001F14</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A meta-analysis of individual participant data reveals an association between circulating levels of IGF-I and prostate cancer risk</title><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name><affiliation><nlm:aff id="A1">Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Appleby, Paul N" sort="Appleby, Paul N" uniqKey="Appleby P" first="Paul N." last="Appleby">Paul N. Appleby</name><affiliation><nlm:aff id="A1">Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Martin, Richard M" sort="Martin, Richard M" uniqKey="Martin R" first="Richard M." last="Martin">Richard M. Martin</name><affiliation><nlm:aff id="A2">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Medical Research Council/University of Bristol Integrative Epidemiology Unit, University of Bristol, and National Institute for Health Research, Bristol Biomedical Research Unit in Nutrition, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Holly, Jeff M P" sort="Holly, Jeff M P" uniqKey="Holly J" first="Jeff M. P." last="Holly">Jeff M. P. Holly</name><affiliation><nlm:aff id="A4">School of Clinical Science, Faculty of Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name><affiliation><nlm:aff id="A5">Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Black, Amanda" sort="Black, Amanda" uniqKey="Black A" first="Amanda" last="Black">Amanda Black</name><affiliation><nlm:aff id="A5">Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Bueno De Mesquita, H B As" sort="Bueno De Mesquita, H B As" uniqKey="Bueno De Mesquita H" first="H. B As" last="Bueno-De-Mesquita">H. B As Bueno-De-Mesquita</name><affiliation><nlm:aff id="A6">Dt. for Determinants of Chronic Diseases, National Institute for Public Health and the Environment (RIVM), Bilthoven, and Dt. of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands, and Dt. of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Chan, June M" sort="Chan, June M" uniqKey="Chan J" first="June M." last="Chan">June M. Chan</name><affiliation><nlm:aff id="A8">Departments of Epidemiology & Biostatistics and Urology, University of California San Francisco, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Chen, Chu" sort="Chen, Chu" uniqKey="Chen C" first="Chu" last="Chen">Chu Chen</name><affiliation><nlm:aff id="A9">Division of Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Chirlaque, Maria Dolores" sort="Chirlaque, Maria Dolores" uniqKey="Chirlaque M" first="Maria-Dolores" last="Chirlaque">Maria-Dolores Chirlaque</name><affiliation><nlm:aff id="A10">Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, and CIBER Epidemiología y Salud Pública, Spain</nlm:aff></affiliation></author><author><name sortKey="Cook, Michael B" sort="Cook, Michael B" uniqKey="Cook M" first="Michael B." last="Cook">Michael B. Cook</name><affiliation><nlm:aff id="A5">Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Deschasaux, Melanie" sort="Deschasaux, Melanie" uniqKey="Deschasaux M" first="Mélanie" last="Deschasaux">Mélanie Deschasaux</name><affiliation><nlm:aff id="A11">Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny, France</nlm:aff></affiliation></author><author><name sortKey="Donovan, Jenny L" sort="Donovan, Jenny L" uniqKey="Donovan J" first="Jenny L." last="Donovan">Jenny L. Donovan</name><affiliation><nlm:aff id="A2">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff></affiliation></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><affiliation><nlm:aff id="A12">Intramural Research Program, National Institute on Aging, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Galan, Pilar" sort="Galan, Pilar" uniqKey="Galan P" first="Pilar" last="Galan">Pilar Galan</name><affiliation><nlm:aff id="A11">Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny, France</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="A13">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, and Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L." last="Giovannucci">Edward L. Giovannucci</name><affiliation><nlm:aff id="A14">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A15">Department of Nutrition and Department of Medicine, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J." last="Gunter">Marc J. Gunter</name><affiliation><nlm:aff id="A7">Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Habel, Laurel A" sort="Habel, Laurel A" uniqKey="Habel L" first="Laurel A." last="Habel">Laurel A. Habel</name><affiliation><nlm:aff id="A16">Division of Research, Kaiser Permanente, Northern California, Oakland, California, USA</nlm:aff></affiliation></author><author><name sortKey="Hamdy, Freddie C" sort="Hamdy, Freddie C" uniqKey="Hamdy F" first="Freddie C." last="Hamdy">Freddie C. Hamdy</name><affiliation><nlm:aff id="A17">Nuffield Department of Surgery, University of Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Helzlsouer, Kathy J" sort="Helzlsouer, Kathy J" uniqKey="Helzlsouer K" first="Kathy J." last="Helzlsouer">Kathy J. Helzlsouer</name><affiliation><nlm:aff id="A18">The Prevention and Research Center, Mercy Medical Center, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Hercberg, Serge" sort="Hercberg, Serge" uniqKey="Hercberg S" first="Serge" last="Hercberg">Serge Hercberg</name><affiliation><nlm:aff id="A11">Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny, France</nlm:aff></affiliation></author><author><name sortKey="Hoover, Robert N" sort="Hoover, Robert N" uniqKey="Hoover R" first="Robert N." last="Hoover">Robert N. Hoover</name><affiliation><nlm:aff id="A5">Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Janssen, Joseph A M J L" sort="Janssen, Joseph A M J L" uniqKey="Janssen J" first="Joseph A. M. J. L." last="Janssen">Joseph A. M. J. L. Janssen</name><affiliation><nlm:aff id="A19">Erasmus MC, Dept Internal Medicine, Rotterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation><nlm:aff id="A20">Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Kubo, Tatsuhiko" sort="Kubo, Tatsuhiko" uniqKey="Kubo T" first="Tatsuhiko" last="Kubo">Tatsuhiko Kubo</name><affiliation><nlm:aff id="A21">University of Occupational and Environmental Health, Kitakyushu, Japan</nlm:aff></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="A22">University of Hawaii Cancer Center, Honolulu, HI, USA</nlm:aff></affiliation></author><author><name sortKey="Metter, E Jeffrey" sort="Metter, E Jeffrey" uniqKey="Metter E" first="E. Jeffrey" last="Metter">E. Jeffrey Metter</name><affiliation><nlm:aff id="A12">Intramural Research Program, National Institute on Aging, Baltimore, MD, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Department of Neurology, University of Tennessee Health Science Center, Memphis, TN</nlm:aff></affiliation></author><author><name sortKey="Mikami, Kazuya" sort="Mikami, Kazuya" uniqKey="Mikami K" first="Kazuya" last="Mikami">Kazuya Mikami</name><affiliation><nlm:aff id="A24">Kyoto Prefectural University of Medicine, Kyoto, Japan</nlm:aff></affiliation></author><author><name sortKey="Morris, Joan K" sort="Morris, Joan K" uniqKey="Morris J" first="Joan K." last="Morris">Joan K. Morris</name><affiliation><nlm:aff id="A25">Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London, UK</nlm:aff></affiliation></author><author><name sortKey="Neal, David E" sort="Neal, David E" uniqKey="Neal D" first="David E." last="Neal">David E. Neal</name><affiliation><nlm:aff id="A26">Department of Oncology, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Neuhouser, Marian L" sort="Neuhouser, Marian L" uniqKey="Neuhouser M" first="Marian L." last="Neuhouser">Marian L. Neuhouser</name><affiliation><nlm:aff id="A9">Division of Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Ozasa, Kotaro" sort="Ozasa, Kotaro" uniqKey="Ozasa K" first="Kotaro" last="Ozasa">Kotaro Ozasa</name><affiliation><nlm:aff id="A27">Radiation Effects Research Foundation, Hiroshima, Japan</nlm:aff></affiliation></author><author><name sortKey="Palli, Domenico" sort="Palli, Domenico" uniqKey="Palli D" first="Domenico" last="Palli">Domenico Palli</name><affiliation><nlm:aff id="A28">Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Florence, Italy</nlm:aff></affiliation></author><author><name sortKey="Platz, Elizabeth A" sort="Platz, Elizabeth A" uniqKey="Platz E" first="Elizabeth A." last="Platz">Elizabeth A. Platz</name><affiliation><nlm:aff id="A29">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Pollak, Michael" sort="Pollak, Michael" uniqKey="Pollak M" first="Michael" last="Pollak">Michael Pollak</name><affiliation><nlm:aff id="A30">Departments of Medicine and Oncology, McGill University, Montreal, QC, Canada</nlm:aff></affiliation></author><author><name sortKey="Price, Alison J" sort="Price, Alison J" uniqKey="Price A" first="Alison J." last="Price">Alison J. Price</name><affiliation><nlm:aff id="A1">Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Roobol, Monique J" sort="Roobol, Monique J" uniqKey="Roobol M" first="Monique J." last="Roobol">Monique J. Roobol</name><affiliation><nlm:aff id="A31">Erasmus MC, Dept of Urology Rotterdam, the Netherlands</nlm:aff></affiliation></author><author><name sortKey="Schaefer, Catherine" sort="Schaefer, Catherine" uniqKey="Schaefer C" first="Catherine" last="Schaefer">Catherine Schaefer</name><affiliation><nlm:aff id="A16">Division of Research, Kaiser Permanente, Northern California, Oakland, California, USA</nlm:aff></affiliation></author><author><name sortKey="Schenk, Jeannette M" sort="Schenk, Jeannette M" uniqKey="Schenk J" first="Jeannette M." last="Schenk">Jeannette M. Schenk</name><affiliation><nlm:aff id="A32">Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Department of Epidemiology, University of Washington, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:aff id="A13">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, and Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia</nlm:aff></affiliation><affiliation><nlm:aff id="A34">Human Genetics Foundation, Torino, Italy</nlm:aff></affiliation></author><author><name sortKey="Stampfer, Meir J" sort="Stampfer, Meir J" uniqKey="Stampfer M" first="Meir J." last="Stampfer">Meir J. Stampfer</name><affiliation><nlm:aff id="A14">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A35">Channing Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Stattin, P R" sort="Stattin, P R" uniqKey="Stattin P" first="P R" last="Stattin">P R Stattin</name><affiliation><nlm:aff id="A36">Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden</nlm:aff></affiliation></author><author><name sortKey="Tamakoshi, Akiko" sort="Tamakoshi, Akiko" uniqKey="Tamakoshi A" first="Akiko" last="Tamakoshi">Akiko Tamakoshi</name><affiliation><nlm:aff id="A37">Hokkaido University Graduate School of Medicine, Sapporo, Japan</nlm:aff></affiliation></author><author><name sortKey="Tangen, Catherine M" sort="Tangen, Catherine M" uniqKey="Tangen C" first="Catherine M." last="Tangen">Catherine M. Tangen</name><affiliation><nlm:aff id="A38">SWOG Statistical Center, Fred Hutchinson Cancer Research Center, and Department of Biostatistics, University of Washington, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Touvier, Mathilde" sort="Touvier, Mathilde" uniqKey="Touvier M" first="Mathilde" last="Touvier">Mathilde Touvier</name><affiliation><nlm:aff id="A11">Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny, France</nlm:aff></affiliation></author><author><name sortKey="Wald, Nicholas J" sort="Wald, Nicholas J" uniqKey="Wald N" first="Nicholas J." last="Wald">Nicholas J. Wald</name><affiliation><nlm:aff id="A26">Department of Oncology, University of Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Weiss, Noel S" sort="Weiss, Noel S" uniqKey="Weiss N" first="Noel S." last="Weiss">Noel S. Weiss</name><affiliation><nlm:aff id="A34">Human Genetics Foundation, Torino, Italy</nlm:aff></affiliation></author><author><name sortKey="Ziegler, Regina G" sort="Ziegler, Regina G" uniqKey="Ziegler R" first="Regina G." last="Ziegler">Regina G. Ziegler</name><affiliation><nlm:aff id="A5">Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Key, Timothy J" sort="Key, Timothy J" uniqKey="Key T" first="Timothy J." last="Key">Timothy J. Key</name><affiliation><nlm:aff id="A1">Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Allen, Naomi E" sort="Allen, Naomi E" uniqKey="Allen N" first="Naomi E." last="Allen">Naomi E. Allen</name><affiliation><nlm:aff id="A39">Clinical Trials Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK</nlm:aff></affiliation></author></analytic><series><title level="j">Cancer research</title><idno type="ISSN">0008-5472</idno><idno type="eISSN">1538-7445</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The role of insulin-like growth factors (IGFs) in prostate cancer development is not fully understood. To investigate the association between circulating concentrations of IGFs (IGF-I, IGF-II, IGFBP-1, IGFBP-2, IGFBP-3) and prostate cancer risk, we pooled individual participant data from 17 prospective and two cross-sectional studies, including up to 10,554 prostate cancer cases and 13,618 control participants. Conditional logistic regression was used to estimate the odds ratios (ORs) for prostate cancer based on the study-specific fifth of each analyte. Overall, IGF-I, IGF-II, IGFBP-2, and IGFBP-3 concentrations were positively associated with prostate cancer risk (Ptrend all ≤ 0.005), and IGFBP-1 was weakly inversely associated with risk (Ptrend = 0.05). However, heterogeneity between the prospective and cross-sectional studies was evident (Pheterogeneity = 0.03), unless the analyses were restricted to prospective studies (with the exception of IGF-II, Pheterogeneity = 0.02). For prospective studies, the OR for men in the highest versus the lowest fifth of each analyte was 1.29 (95% confidence interval=1.16-1.43) for IGF-I, 0.81 (0.68-0.96) for IGFBP-1, and 1.25 (1.12-1.40) for IGFBP-3. These associations did not differ significantly by time-to-diagnosis or tumor stage or grade. After mutual adjustment for each of the other analytes, only IGF-I remained associated with risk. Our collaborative study represents the largest pooled analysis of the relationship between prostate cancer risk and circulating concentrations of IGF-I, providing strong evidence that IGF-I is highly likely to be involved in prostate cancer development.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">2984705R</journal-id><journal-id journal-id-type="pubmed-jr-id">2786</journal-id><journal-id journal-id-type="nlm-ta">Cancer Res</journal-id><journal-id journal-id-type="iso-abbrev">Cancer Res.</journal-id><journal-title-group><journal-title>Cancer research</journal-title></journal-title-group><issn pub-type="ppub">0008-5472</issn><issn pub-type="epub">1538-7445</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26921328</article-id><article-id pub-id-type="pmc">4873385</article-id><article-id pub-id-type="doi">10.1158/0008-5472.CAN-15-1551</article-id><article-id pub-id-type="manuscript">NIHMS774221</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>A meta-analysis of individual participant data reveals an association between circulating levels of IGF-I and prostate cancer risk</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Travis</surname><given-names>Ruth C.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Appleby</surname><given-names>Paul N.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Martin</surname><given-names>Richard M.</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Holly</surname><given-names>Jeff M.P.</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Albanes</surname><given-names>Demetrius</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Black</surname><given-names>Amanda</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Bueno-de-Mesquita</surname><given-names>H.B(as).</given-names></name><xref ref-type="aff" rid="A6">6</xref><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Chan</surname><given-names>June M.</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Chu</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Chirlaque</surname><given-names>Maria-Dolores</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Cook</surname><given-names>Michael B.</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Deschasaux</surname><given-names>Mélanie</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Donovan</surname><given-names>Jenny L.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Ferrucci</surname><given-names>Luigi</given-names></name><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Galan</surname><given-names>Pilar</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Giles</surname><given-names>Graham G.</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Giovannucci</surname><given-names>Edward L.</given-names></name><xref ref-type="aff" rid="A14">14</xref><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Gunter</surname><given-names>Marc J.</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib 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contrib-type="author"><name><surname>Kaaks</surname><given-names>Rudolf</given-names></name><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Kubo</surname><given-names>Tatsuhiko</given-names></name><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Le Marchand</surname><given-names>Loic</given-names></name><xref ref-type="aff" rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>Metter</surname><given-names>E. Jeffrey</given-names></name><xref ref-type="aff" rid="A12">12</xref><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Mikami</surname><given-names>Kazuya</given-names></name><xref ref-type="aff" rid="A24">24</xref></contrib><contrib contrib-type="author"><name><surname>Morris</surname><given-names>Joan K.</given-names></name><xref ref-type="aff" rid="A25">25</xref></contrib><contrib contrib-type="author"><name><surname>Neal</surname><given-names>David E.</given-names></name><xref ref-type="aff" rid="A26">26</xref></contrib><contrib contrib-type="author"><name><surname>Neuhouser</surname><given-names>Marian L.</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Ozasa</surname><given-names>Kotaro</given-names></name><xref ref-type="aff" rid="A27">27</xref></contrib><contrib contrib-type="author"><name><surname>Palli</surname><given-names>Domenico</given-names></name><xref ref-type="aff" rid="A28">28</xref></contrib><contrib contrib-type="author"><name><surname>Platz</surname><given-names>Elizabeth A.</given-names></name><xref ref-type="aff" rid="A29">29</xref></contrib><contrib contrib-type="author"><name><surname>Pollak</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="A30">30</xref></contrib><contrib contrib-type="author"><name><surname>Price</surname><given-names>Alison J.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Roobol</surname><given-names>Monique J.</given-names></name><xref ref-type="aff" rid="A31">31</xref></contrib><contrib contrib-type="author"><name><surname>Schaefer</surname><given-names>Catherine</given-names></name><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Schenk</surname><given-names>Jeannette M.</given-names></name><xref ref-type="aff" rid="A32">32</xref><xref ref-type="aff" rid="A33">33</xref></contrib><contrib contrib-type="author"><name><surname>Severi</surname><given-names>Gianluca</given-names></name><xref ref-type="aff" rid="A13">13</xref><xref ref-type="aff" rid="A34">34</xref></contrib><contrib contrib-type="author"><name><surname>Stampfer</surname><given-names>Meir J.</given-names></name><xref ref-type="aff" rid="A14">14</xref><xref ref-type="aff" rid="A35">35</xref></contrib><contrib contrib-type="author"><name><surname>Stattin</surname><given-names>Pär</given-names></name><xref ref-type="aff" rid="A36">36</xref></contrib><contrib contrib-type="author"><name><surname>Tamakoshi</surname><given-names>Akiko</given-names></name><xref ref-type="aff" rid="A37">37</xref></contrib><contrib contrib-type="author"><name><surname>Tangen</surname><given-names>Catherine M.</given-names></name><xref ref-type="aff" rid="A38">38</xref></contrib><contrib contrib-type="author"><name><surname>Touvier</surname><given-names>Mathilde</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Wald</surname><given-names>Nicholas J.</given-names></name><xref ref-type="aff" rid="A26">26</xref></contrib><contrib contrib-type="author"><name><surname>Weiss</surname><given-names>Noel S.</given-names></name><xref ref-type="aff" rid="A34">34</xref></contrib><contrib contrib-type="author"><name><surname>Ziegler</surname><given-names>Regina G.</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Key</surname><given-names>Timothy J.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Allen</surname><given-names>Naomi E.</given-names></name><xref ref-type="aff" rid="A39">39</xref></contrib><on-behalf-of>on behalf of the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group</on-behalf-of></contrib-group><aff id="A1"><label>1</label>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK</aff><aff id="A2"><label>2</label>School of Social and Community Medicine, University of Bristol, Bristol, UK</aff><aff id="A3"><label>3</label>Medical Research Council/University of Bristol Integrative Epidemiology Unit, University of Bristol, and National Institute for Health Research, Bristol Biomedical Research Unit in Nutrition, Bristol, UK</aff><aff id="A4"><label>4</label>School of Clinical Science, Faculty of Medicine, University of Bristol, Bristol, UK</aff><aff id="A5"><label>5</label>Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA</aff><aff id="A6"><label>6</label>Dt. for Determinants of Chronic Diseases, National Institute for Public Health and the Environment (RIVM), Bilthoven, and Dt. of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands, and Dt. of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia</aff><aff id="A7"><label>7</label>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK</aff><aff id="A8"><label>8</label>Departments of Epidemiology & Biostatistics and Urology, University of California San Francisco, CA, USA</aff><aff id="A9"><label>9</label>Division of Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA</aff><aff id="A10"><label>10</label>Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, and CIBER Epidemiología y Salud Pública, Spain</aff><aff id="A11"><label>11</label>Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny, France</aff><aff id="A12"><label>12</label>Intramural Research Program, National Institute on Aging, Baltimore, MD, USA</aff><aff id="A13"><label>13</label>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, and Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia</aff><aff id="A14"><label>14</label>Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</aff><aff id="A15"><label>15</label>Department of Nutrition and Department of Medicine, Harvard School of Public Health, Boston, MA, USA</aff><aff id="A16"><label>16</label>Division of Research, Kaiser Permanente, Northern California, Oakland, California, USA</aff><aff id="A17"><label>17</label>Nuffield Department of Surgery, University of Oxford, UK</aff><aff id="A18"><label>18</label>The Prevention and Research Center, Mercy Medical Center, Baltimore, MD, USA</aff><aff id="A19"><label>19</label>Erasmus MC, Dept Internal Medicine, Rotterdam, the Netherlands</aff><aff id="A20"><label>20</label>Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany</aff><aff id="A21"><label>21</label>University of Occupational and Environmental Health, Kitakyushu, Japan</aff><aff id="A22"><label>22</label>University of Hawaii Cancer Center, Honolulu, HI, USA</aff><aff id="A23"><label>23</label>Department of Neurology, University of Tennessee Health Science Center, Memphis, TN</aff><aff id="A24"><label>24</label>Kyoto Prefectural University of Medicine, Kyoto, Japan</aff><aff id="A25"><label>25</label>Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London, UK</aff><aff id="A26"><label>26</label>Department of Oncology, University of Cambridge, UK</aff><aff id="A27"><label>27</label>Radiation Effects Research Foundation, Hiroshima, Japan</aff><aff id="A28"><label>28</label>Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Florence, Italy</aff><aff id="A29"><label>29</label>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA</aff><aff id="A30"><label>30</label>Departments of Medicine and Oncology, McGill University, Montreal, QC, Canada</aff><aff id="A31"><label>31</label>Erasmus MC, Dept of Urology Rotterdam, the Netherlands</aff><aff id="A32"><label>32</label>Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA</aff><aff id="A33"><label>33</label>Department of Epidemiology, University of Washington, Seattle, WA, USA</aff><aff id="A34"><label>34</label>Human Genetics Foundation, Torino, Italy</aff><aff id="A35"><label>35</label>Channing Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA</aff><aff id="A36"><label>36</label>Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden</aff><aff id="A37"><label>37</label>Hokkaido University Graduate School of Medicine, Sapporo, Japan</aff><aff id="A38"><label>38</label>SWOG Statistical Center, Fred Hutchinson Cancer Research Center, and Department of Biostatistics, University of Washington, Seattle, WA, USA</aff><aff id="A39"><label>39</label>Clinical Trials Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK</aff><author-notes><corresp id="CR1"><bold>Correspondence to:</bold> Ruth C. Travis DPhil, Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group, Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford OX3 7LF, UK. Tel: +44 1865 289600, Fax: +44 1865 289610, <email>ruth.travis@ceu.ox.ac.uk</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>5</day><month>4</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>26</day><month>2</month><year>2016</year></pub-date><pub-date pub-type="ppub"><day>15</day><month>4</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>15</day><month>10</month><year>2016</year></pub-date><volume>76</volume><issue>8</issue><fpage>2288</fpage><lpage>2300</lpage><pmc-comment>elocation-id from pubmed: 10.1158/0008-5472.CAN-15-1551</pmc-comment>
<abstract><p id="P1">The role of insulin-like growth factors (IGFs) in prostate cancer development is not fully understood. To investigate the association between circulating concentrations of IGFs (IGF-I, IGF-II, IGFBP-1, IGFBP-2, IGFBP-3) and prostate cancer risk, we pooled individual participant data from 17 prospective and two cross-sectional studies, including up to 10,554 prostate cancer cases and 13,618 control participants. Conditional logistic regression was used to estimate the odds ratios (ORs) for prostate cancer based on the study-specific fifth of each analyte. Overall, IGF-I, IGF-II, IGFBP-2, and IGFBP-3 concentrations were positively associated with prostate cancer risk (Ptrend all ≤ 0.005), and IGFBP-1 was weakly inversely associated with risk (Ptrend = 0.05). However, heterogeneity between the prospective and cross-sectional studies was evident (Pheterogeneity = 0.03), unless the analyses were restricted to prospective studies (with the exception of IGF-II, Pheterogeneity = 0.02). For prospective studies, the OR for men in the highest versus the lowest fifth of each analyte was 1.29 (95% confidence interval=1.16-1.43) for IGF-I, 0.81 (0.68-0.96) for IGFBP-1, and 1.25 (1.12-1.40) for IGFBP-3. These associations did not differ significantly by time-to-diagnosis or tumor stage or grade. After mutual adjustment for each of the other analytes, only IGF-I remained associated with risk. Our collaborative study represents the largest pooled analysis of the relationship between prostate cancer risk and circulating concentrations of IGF-I, providing strong evidence that IGF-I is highly likely to be involved in prostate cancer development.</p></abstract><kwd-group><kwd>prostate cancer</kwd><kwd>insulin-like growth factor</kwd><kwd>insulin-like growth factor binding protein</kwd><kwd>pooled analysis</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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